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Conserved domains on  [gi|2462612650|ref|XP_054213366|]
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zinc finger protein 467 isoform X3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-606 1.13e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 231 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 307
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 308 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTH-KQHLVRHQRVHQAAGPARPSPDSSASPHSTAPSP 386
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 387 TPS--------FPGPKPFACSDCGLSFGwKKNLATHQCLHRSEGRPfgCDECALGATVDAPAAKPLASAPGGPGCGPGSD 458
Cdd:COG5048   196 IPSssensplsSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 459 PVVPQRAPSGERSFF----CPDCGRGFSHGQHLARHPR--VHTGE--RPFACT--QCDRRFGSRPNLVAHSRAHSGARPF 528
Cdd:COG5048   273 SSPNESDSSSEKGFSlpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 529 AC--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARSFSSKTNLVRHQAIHTGSRP--FSCPQCGKSFSRKT 597
Cdd:COG5048   353 KEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHY 432


                  ....*....
gi 2462612650 598 HLVRHQLIH 606
Cdd:COG5048   433 NLIPHKKIH 441
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-606 1.13e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 231 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 307
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 308 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTH-KQHLVRHQRVHQAAGPARPSPDSSASPHSTAPSP 386
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 387 TPS--------FPGPKPFACSDCGLSFGwKKNLATHQCLHRSEGRPfgCDECALGATVDAPAAKPLASAPGGPGCGPGSD 458
Cdd:COG5048   196 IPSssensplsSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 459 PVVPQRAPSGERSFF----CPDCGRGFSHGQHLARHPR--VHTGE--RPFACT--QCDRRFGSRPNLVAHSRAHSGARPF 528
Cdd:COG5048   273 SSPNESDSSSEKGFSlpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 529 AC--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARSFSSKTNLVRHQAIHTGSRP--FSCPQCGKSFSRKT 597
Cdd:COG5048   353 KEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHY 432


                  ....*....
gi 2462612650 598 HLVRHQLIH 606
Cdd:COG5048   433 NLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-296 1.60e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.60e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462612650 271 HLTRHLRTHTGERPYPCAECGKRFSQ 296
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-606 1.13e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 231 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 307
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 308 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTH-KQHLVRHQRVHQAAGPARPSPDSSASPHSTAPSP 386
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 387 TPS--------FPGPKPFACSDCGLSFGwKKNLATHQCLHRSEGRPfgCDECALGATVDAPAAKPLASAPGGPGCGPGSD 458
Cdd:COG5048   196 IPSssensplsSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 459 PVVPQRAPSGERSFF----CPDCGRGFSHGQHLARHPR--VHTGE--RPFACT--QCDRRFGSRPNLVAHSRAHSGARPF 528
Cdd:COG5048   273 SSPNESDSSSEKGFSlpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 529 AC--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARSFSSKTNLVRHQAIHTGSRP--FSCPQCGKSFSRKT 597
Cdd:COG5048   353 KEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHY 432


                  ....*....
gi 2462612650 598 HLVRHQLIH 606
Cdd:COG5048   433 NLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-606 1.32e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 1.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 283 RPYPCAECGKRFSQKIHLGSHQKTHTGERPFPCT--ECEKRFRKKTHLIRHQRIHTGERPYQCAQCarsfthkqhlvRHQ 360
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKS-----------LPL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 361 RVHQAAGPARPSPDSSASPHSTAPSPTPSFPGPKPFACSDCGLSFgwKKNLATHQCLHRSEGRPfgcdecalgatVDAPA 440
Cdd:COG5048   101 SNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISN--LRNNPLPGNNSSSVNTP-----------QSNSL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 441 AKPLASAPGGPGCGPGSDPVVPQRAPSGERSFFCPDCGRGFSHGQHLARHPRVHTGERPFACTQCDRRFGSRPNLVAHSR 520
Cdd:COG5048   168 HPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSS 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 521 AHSGARPFACAQCGR------RFSRKSHLGRHQAVHTG-SRPHACAVCARSFSSKTNLVRHQ--AIHTGS--RPFSCP-- 587
Cdd:COG5048   248 LSSSDSSSSASESPRsslptaSSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPys 327

                         330
                  ....*....|....*....
gi 2462612650 588 QCGKSFSRKTHLVRHQLIH 606
Cdd:COG5048   328 LCGKLFSRNDALKRHILLH 346
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-296 1.60e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.60e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462612650 271 HLTRHLRTHTGERPYPCAECGKRFSQ 296
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
570-595 7.77e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.77e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462612650 570 NLVRHQAIHTGSRPFSCPQCGKSFSR 595
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-352 4.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.68e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462612650 327 HLIRHQRIHTGERPYQCAQCARSFTH 352
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 257-279 5.79e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 5.79e-04
                          10        20
                  ....*....|....*....|...
gi 2462612650 257 FPCSECDKRFSKKAHLTRHLRTH 279
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 584-606 6.91e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 6.91e-04
                          10        20
                  ....*....|....*....|...
gi 2462612650 584 FSCPQCGKSFSRKTHLVRHQLIH 606
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
302-322 2.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.39e-03
                          10        20
                  ....*....|....*....|.
gi 2462612650 302 SHQKTHTGERPFPCTECEKRF 322
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 313-335 2.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.78e-03
                          10        20
                  ....*....|....*....|...
gi 2462612650 313 FPCTECEKRFRKKTHLIRHQRIH 335
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-268 2.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.88e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462612650 243 HMLLHQRSHRGERPFPCSECDKRFSK 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-359 3.00e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 3.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 228 PCACPDCGRSFTQRAHMLLHQRS--HRGE--RPFPCSE--CDKRFSKKAHLTRHLRTHTGERPYPC--AECGKRFSQKI- 298
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLn 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612650 299 --HLGSHQK--------------------------------THTGERP--FPCTECEKRFRKKTHLIRHQRIHTGERPYQ 342
Cdd:COG5048   369 nePPQSLQQykdlkndkksetlsnscirnfkrdsnlslhiiTHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                         170
                  ....*....|....*..
gi 2462612650 343 CAQCaRSFTHKQHLVRH 359
Cdd:COG5048   449 CSIL-KSFRRDLDLSNH 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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