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Conserved domains on  [gi|2462612646|ref|XP_054213364|]
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zinc finger protein 467 isoform X2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
114-489 1.01e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 1.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 114 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 190
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 191 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTH-KQHLVRHQRVHQAAGPARPSPDSSASPHSTAPSP 269
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 270 TPS--------FPGPKPFACSDCGLSFGwKKNLATHQCLHRSEGRPfgCDECALGATVDAPAAKPLASAPGGPGCGPGSD 341
Cdd:COG5048   196 IPSssensplsSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 342 PVVPQRAPSGERSFF----CPDCGRGFSHGQHLARHPR--VHTGE--RPFACT--QCDRRFGSRPNLVAHSRAHSGARPF 411
Cdd:COG5048   273 SSPNESDSSSEKGFSlpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 412 AC--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARSFSSKTNLVRHQAIHTGSRP--FSCPQCGKSFSRKT 480
Cdd:COG5048   353 KEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHY 432


                  ....*....
gi 2462612646 481 HLVRHQLIH 489
Cdd:COG5048   433 NLIPHKKIH 441
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
114-489 1.01e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 1.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 114 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 190
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 191 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTH-KQHLVRHQRVHQAAGPARPSPDSSASPHSTAPSP 269
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 270 TPS--------FPGPKPFACSDCGLSFGwKKNLATHQCLHRSEGRPfgCDECALGATVDAPAAKPLASAPGGPGCGPGSD 341
Cdd:COG5048   196 IPSssensplsSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 342 PVVPQRAPSGERSFF----CPDCGRGFSHGQHLARHPR--VHTGE--RPFACT--QCDRRFGSRPNLVAHSRAHSGARPF 411
Cdd:COG5048   273 SSPNESDSSSEKGFSlpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 412 AC--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARSFSSKTNLVRHQAIHTGSRP--FSCPQCGKSFSRKT 480
Cdd:COG5048   353 KEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHY 432


                  ....*....
gi 2462612646 481 HLVRHQLIH 489
Cdd:COG5048   433 NLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
154-179 4.10e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.10e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462612646 154 HLTRHLRTHTGERPYPCAECGKRFSQ 179
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
114-489 1.01e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 1.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 114 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 190
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 191 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTH-KQHLVRHQRVHQAAGPARPSPDSSASPHSTAPSP 269
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 270 TPS--------FPGPKPFACSDCGLSFGwKKNLATHQCLHRSEGRPfgCDECALGATVDAPAAKPLASAPGGPGCGPGSD 341
Cdd:COG5048   196 IPSssensplsSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 342 PVVPQRAPSGERSFF----CPDCGRGFSHGQHLARHPR--VHTGE--RPFACT--QCDRRFGSRPNLVAHSRAHSGARPF 411
Cdd:COG5048   273 SSPNESDSSSEKGFSlpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 412 AC--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARSFSSKTNLVRHQAIHTGSRP--FSCPQCGKSFSRKT 480
Cdd:COG5048   353 KEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHY 432


                  ....*....
gi 2462612646 481 HLVRHQLIH 489
Cdd:COG5048   433 NLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-489 1.18e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 166 RPYPCAECGKRFSQKIHLGSHQKTHTGERPFPCT--ECEKRFRKKTHLIRHQRIHTGERPYQCAQCarsfthkqhlvRHQ 243
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKS-----------LPL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 244 RVHQAAGPARPSPDSSASPHSTAPSPTPSFPGPKPFACSDCGLSFgwKKNLATHQCLHRSEGRPfgcdecalgatVDAPA 323
Cdd:COG5048   101 SNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISN--LRNNPLPGNNSSSVNTP-----------QSNSL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 324 AKPLASAPGGPGCGPGSDPVVPQRAPSGERSFFCPDCGRGFSHGQHLARHPRVHTGERPFACTQCDRRFGSRPNLVAHSR 403
Cdd:COG5048   168 HPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSS 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 404 AHSGARPFACAQCGR------RFSRKSHLGRHQAVHTG-SRPHACAVCARSFSSKTNLVRHQ--AIHTGS--RPFSCP-- 470
Cdd:COG5048   248 LSSSDSSSSASESPRsslptaSSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPys 327

                         330
                  ....*....|....*....
gi 2462612646 471 QCGKSFSRKTHLVRHQLIH 489
Cdd:COG5048   328 LCGKLFSRNDALKRHILLH 346
zf-H2C2_2 pfam13465
Zinc-finger double domain;
154-179 4.10e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.10e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462612646 154 HLTRHLRTHTGERPYPCAECGKRFSQ 179
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 1.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.89e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462612646 453 NLVRHQAIHTGSRPFSCPQCGKSFSR 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-235 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462612646 210 HLIRHQRIHTGERPYQCAQCARSFTH 235
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 140-162 1.51e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.51e-03
                          10        20
                  ....*....|....*....|...
gi 2462612646 140 FPCSECDKRFSKKAHLTRHLRTH 162
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 467-489 1.80e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.80e-03
                          10        20
                  ....*....|....*....|...
gi 2462612646 467 FSCPQCGKSFSRKTHLVRHQLIH 489
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
111-242 2.70e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 111 PCACPDCGRSFTQRAHMLLHQRS--HRGE--RPFPCSE--CDKRFSKKAHLTRHLRTHTGERPYPC--AECGKRFSQKI- 181
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLn 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612646 182 --HLGSHQK--------------------------------THTGERP--FPCTECEKRFRKKTHLIRHQRIHTGERPYQ 225
Cdd:COG5048   369 nePPQSLQQykdlkndkksetlsnscirnfkrdsnlslhiiTHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                         170
                  ....*....|....*..
gi 2462612646 226 CAQCaRSFTHKQHLVRH 242
Cdd:COG5048   449 CSIL-KSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
185-205 5.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.08e-03
                          10        20
                  ....*....|....*....|.
gi 2462612646 185 SHQKTHTGERPFPCTECEKRF 205
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
126-151 6.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.06e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462612646 126 HMLLHQRSHRGERPFPCSECDKRFSK 151
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 196-218 6.92e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.92e-03
                          10        20
                  ....*....|....*....|...
gi 2462612646 196 FPCTECEKRFRKKTHLIRHQRIH 218
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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