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Conserved domains on  [gi|2462512252|ref|XP_054194055|]
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pappalysin-2 isoform X1 [Homo sapiens]

Protein Classification

Laminin_G_3 and ZnMc_pappalysin_like domain-containing protein( domain architecture ID 11210779)

protein containing domains Laminin_G_3, ZnMc_pappalysin_like, myxo_disulf_rpt, and CCP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 634-831 3.01e-53

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


:

Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 186.39  E-value: 3.01e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  634 NMLNDF------DDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKD 707
Cdd:cd04275     32 DVLNDDysglnaGVDLGIEFVLAGTTRTVNSAWPVFAGSGTEDAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLV 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  708 AVT-HLGGIVLSPAYYGMPG-----HTDTMIHEVGHVLGLYHVFKGVSerescndpcketvPSMETGDLCADTAPTPKSE 781
Cdd:cd04275    112 SLAfITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHTFQGGS-------------PCCTTGDYVADTPAEASPS 178

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462512252  782 lCREPEPTsDTCGFTRFPgAPFTNYMSYTDDNCTDNFTPNQVARMHCYLD 831
Cdd:cd04275    179 -YGCPAGR-DTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQVTRMRSYLD 225
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 282-437 5.50e-21

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


:

Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 91.29  E-value: 5.50e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  282 IPREAFTVEAWVKPEGGQNNPAIIAGVFdncshtvSDKGWALGIRSGKdkgkrdaRFFFSLCTDRVKKATIlISHSRYQP 361
Cdd:pfam13385   14 LPTSDFTVSAWVKPDSLPGWARAIISSS-------GGGGYSLGLDGDG-------RLRFAVNGGNGGWDTV-TSGASVPL 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462512252  362 GTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNspfmASCRSLLLGGDSSEDgHYFRGHLGTLVFWSTALPQSH 437
Cdd:pfam13385   79 GQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPP----GTGGPLYIGRSPGGD-DYFNGLIDEVRIYDRALSAAE 149
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 1112-1151 3.89e-15

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


:

Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 70.48  E-value: 3.89e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462512252 1112 APYCGDGKVSErlGEECDDGDLVSGDGCSKVCELEEGFNC 1151
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1525-1591 1.21e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.38  E-value: 1.21e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462512252 1525 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYVAESAEgkvrnkllkIQCLEGGIW--EQGSCI 1591
Cdd:cd00033      1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST---------ITCTENGGWspPPPTCE 57
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1722-1758 3.02e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.70  E-value: 3.02e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2462512252  1722 PDPVLVHC-IQSCEPFQADGWCDTINNRAYCHYDGGDC 1758
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch super family cl02419
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 585-612 3.10e-04

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


The actual alignment was detected with superfamily member smart00004:

Pssm-ID: 470573  Cd Length: 38  Bit Score: 39.62  E-value: 3.10e-04
                            10        20
                    ....*....|....*....|....*...
gi 2462512252   585 NCEpSKIGNDHCDPECEHPLTGYDGGDC 612
Cdd:smart00004   12 QCW-DKFGDGVCDEECNNAECLWDGGDC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
1467-1521 7.92e-04

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 39.02  E-value: 7.92e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462512252 1467 PDPSLVNYANFSCSEGTKFLK-RCSISCVPPAKLQGlSPWLTCLEDGLWSLPEVYC 1521
Cdd:pfam00084    2 PPPPDIPNGKVSATKNEYNYGaSVSYECDPGYRLVG-SPTITCQEDGTWSPPFPEC 56
 
Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 634-831 3.01e-53

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 186.39  E-value: 3.01e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  634 NMLNDF------DDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKD 707
Cdd:cd04275     32 DVLNDDysglnaGVDLGIEFVLAGTTRTVNSAWPVFAGSGTEDAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLV 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  708 AVT-HLGGIVLSPAYYGMPG-----HTDTMIHEVGHVLGLYHVFKGVSerescndpcketvPSMETGDLCADTAPTPKSE 781
Cdd:cd04275    112 SLAfITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHTFQGGS-------------PCCTTGDYVADTPAEASPS 178

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462512252  782 lCREPEPTsDTCGFTRFPgAPFTNYMSYTDDNCTDNFTPNQVARMHCYLD 831
Cdd:cd04275    179 -YGCPAGR-DTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQVTRMRSYLD 225
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 282-437 5.50e-21

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 91.29  E-value: 5.50e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  282 IPREAFTVEAWVKPEGGQNNPAIIAGVFdncshtvSDKGWALGIRSGKdkgkrdaRFFFSLCTDRVKKATIlISHSRYQP 361
Cdd:pfam13385   14 LPTSDFTVSAWVKPDSLPGWARAIISSS-------GGGGYSLGLDGDG-------RLRFAVNGGNGGWDTV-TSGASVPL 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462512252  362 GTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNspfmASCRSLLLGGDSSEDgHYFRGHLGTLVFWSTALPQSH 437
Cdd:pfam13385   79 GQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPP----GTGGPLYIGRSPGGD-DYFNGLIDEVRIYDRALSAAE 149
LamGL smart00560
LamG-like jellyroll fold domain;
286-433 2.89e-19

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 85.55  E-value: 2.89e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252   286 AFTVEAWVKPEGGQNNPAIIagvfdncshtvsdKGWALGIRSGKDKgkrDARFFFSLCTDRvkKATILISHSRYQP-GTW 364
Cdd:smart00560    2 SFTLEAWVKLESAGGSQPII-------------TGAAVAQPTISEK---ALTFFLRAKSVQ--GWQTARTGATADWiGVW 63

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462512252   365 THVAATYDG--RHMALYVDGTQVASSLDQSGPLNSPFMASCRsLLLGGDSsedGHYFRGHLGTLVFWSTAL 433
Cdd:smart00560   64 VHLAGVYDGgaGKLSLYVNGVEVATSETQPSPSSGNLPQGGR-ILLGGAG---GENFSGRLDEVRVYNRAL 130
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 1112-1151 3.89e-15

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 70.48  E-value: 3.89e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462512252 1112 APYCGDGKVSErlGEECDDGDLVSGDGCSKVCELEEGFNC 1151
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
MJ1470 COG5306
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 263-394 4.83e-07

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 54.52  E-value: 4.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  263 LYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQNNPAIiagvfdncshtVSDKGWALGIRSGkdkgkrdARFFfsl 342
Cdd:COG5306    175 AQFDGTSPLVVPASPSLALDAGGGFTFSAWIKPAQLDGNAVL-----------YSRRDGANGLDNG-------APFV--- 233

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462512252  343 ctdRVKKATILISHS--RYQPGTWTHVAATYDGRHMALYVDGtQVASSLDQSGP 394
Cdd:COG5306    234 ---EVGGAGGTRSAAgaPLAAGTWHHLAVVADAGKVTLYVNG-VAAGSLDASLP 283
Peptidase_M43 pfam05572
Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a ...
 679-831 9.23e-06

Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.


Pssm-ID: 368506  Cd Length: 152  Bit Score: 47.61  E-value: 9.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  679 NSTHFLNIYFASSVREDL---AGAATWPWDKDAVTHLGGIVLSPAY-YGMPGHTD---TMIHEVGHVLGLYHVFKGVSER 751
Cdd:pfam05572   13 DNEKYMNVYIQNDLADGLtnnSGVAWYPDSGMSADGTARVVFNGAYlAADPTSTNfssTLTHEFGHFLGLIHTFEGGCER 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  752 escndpcketvpsmETGDLCADTaptpksELCREPEPTSDTCGFTRFPGAPF--TNYMSYTDdnCTDNFTPNQVARMHCY 829
Cdd:pfam05572   93 --------------GEGDKVPDT------PSYTGGEVSLRNKDLFNCNGEPInsQNQMDYNG--CYAMFTQDQVDRMVEV 150


                   ..
gi 2462512252  830 LD 831
Cdd:pfam05572  151 LA 152
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1525-1591 1.21e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.38  E-value: 1.21e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462512252 1525 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYVAESAEgkvrnkllkIQCLEGGIW--EQGSCI 1591
Cdd:cd00033      1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST---------ITCTENGGWspPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
1525-1588 2.28e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 43.64  E-value: 2.28e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462512252 1525 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYvaesaegkvRNKLLKIQCLEGGIWEQG 1588
Cdd:pfam00084    1 CPPPPDIPNGKV---SATKNEYNYGASVSYECDPGYR---------LVGSPTITCQEDGTWSPP 52
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1722-1758 3.02e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.70  E-value: 3.02e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2462512252  1722 PDPVLVHC-IQSCEPFQADGWCDTINNRAYCHYDGGDC 1758
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1525-1585 1.83e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.97  E-value: 1.83e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462512252  1525 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYVAESAEgkvrnkllkIQCLEGGIW 1585
Cdd:smart00032    1 CPPPPDIENGTV---TSSSGTYSYGDTVTYSCDPGYTLIGSST---------ITCLENGTW 49
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 585-612 3.10e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 39.62  E-value: 3.10e-04
                            10        20
                    ....*....|....*....|....*...
gi 2462512252   585 NCEpSKIGNDHCDPECEHPLTGYDGGDC 612
Cdd:smart00004   12 QCW-DKFGDGVCDEECNNAECLWDGGDC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
1467-1521 7.92e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 39.02  E-value: 7.92e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462512252 1467 PDPSLVNYANFSCSEGTKFLK-RCSISCVPPAKLQGlSPWLTCLEDGLWSLPEVYC 1521
Cdd:pfam00084    2 PPPPDIPNGKVSATKNEYNYGaSVSYECDPGYRLVG-SPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1467-1522 6.16e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 36.67  E-value: 6.16e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462512252 1467 PDPSLVNYANFSCSEGT-KFLKRCSISCVPPAKLQGlSPWLTCLEDGLWSLPEVYCK 1522
Cdd:cd00033      2 PPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVG-SSTITCTENGGWSPPPPTCE 57
 
Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 634-831 3.01e-53

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 186.39  E-value: 3.01e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  634 NMLNDF------DDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKD 707
Cdd:cd04275     32 DVLNDDysglnaGVDLGIEFVLAGTTRTVNSAWPVFAGSGTEDAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLV 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  708 AVT-HLGGIVLSPAYYGMPG-----HTDTMIHEVGHVLGLYHVFKGVSerescndpcketvPSMETGDLCADTAPTPKSE 781
Cdd:cd04275    112 SLAfITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHTFQGGS-------------PCCTTGDYVADTPAEASPS 178

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462512252  782 lCREPEPTsDTCGFTRFPgAPFTNYMSYTDDNCTDNFTPNQVARMHCYLD 831
Cdd:cd04275    179 -YGCPAGR-DTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQVTRMRSYLD 225
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 282-437 5.50e-21

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 91.29  E-value: 5.50e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  282 IPREAFTVEAWVKPEGGQNNPAIIAGVFdncshtvSDKGWALGIRSGKdkgkrdaRFFFSLCTDRVKKATIlISHSRYQP 361
Cdd:pfam13385   14 LPTSDFTVSAWVKPDSLPGWARAIISSS-------GGGGYSLGLDGDG-------RLRFAVNGGNGGWDTV-TSGASVPL 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462512252  362 GTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNspfmASCRSLLLGGDSSEDgHYFRGHLGTLVFWSTALPQSH 437
Cdd:pfam13385   79 GQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPP----GTGGPLYIGRSPGGD-DYFNGLIDEVRIYDRALSAAE 149
LamGL smart00560
LamG-like jellyroll fold domain;
286-433 2.89e-19

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 85.55  E-value: 2.89e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252   286 AFTVEAWVKPEGGQNNPAIIagvfdncshtvsdKGWALGIRSGKDKgkrDARFFFSLCTDRvkKATILISHSRYQP-GTW 364
Cdd:smart00560    2 SFTLEAWVKLESAGGSQPII-------------TGAAVAQPTISEK---ALTFFLRAKSVQ--GWQTARTGATADWiGVW 63

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462512252   365 THVAATYDG--RHMALYVDGTQVASSLDQSGPLNSPFMASCRsLLLGGDSsedGHYFRGHLGTLVFWSTAL 433
Cdd:smart00560   64 VHLAGVYDGgaGKLSLYVNGVEVATSETQPSPSSGNLPQGGR-ILLGGAG---GENFSGRLDEVRVYNRAL 130
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 1112-1151 3.89e-15

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 70.48  E-value: 3.89e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462512252 1112 APYCGDGKVSErlGEECDDGDLVSGDGCSKVCELEEGFNC 1151
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
MJ1470 COG5306
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 263-394 4.83e-07

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 54.52  E-value: 4.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  263 LYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQNNPAIiagvfdncshtVSDKGWALGIRSGkdkgkrdARFFfsl 342
Cdd:COG5306    175 AQFDGTSPLVVPASPSLALDAGGGFTFSAWIKPAQLDGNAVL-----------YSRRDGANGLDNG-------APFV--- 233

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462512252  343 ctdRVKKATILISHS--RYQPGTWTHVAATYDGRHMALYVDGtQVASSLDQSGP 394
Cdd:COG5306    234 ---EVGGAGGTRSAAgaPLAAGTWHHLAVVADAGKVTLYVNG-VAAGSLDASLP 283
Peptidase_M43 pfam05572
Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a ...
 679-831 9.23e-06

Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.


Pssm-ID: 368506  Cd Length: 152  Bit Score: 47.61  E-value: 9.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  679 NSTHFLNIYFASSVREDL---AGAATWPWDKDAVTHLGGIVLSPAY-YGMPGHTD---TMIHEVGHVLGLYHVFKGVSER 751
Cdd:pfam05572   13 DNEKYMNVYIQNDLADGLtnnSGVAWYPDSGMSADGTARVVFNGAYlAADPTSTNfssTLTHEFGHFLGLIHTFEGGCER 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  752 escndpcketvpsmETGDLCADTaptpksELCREPEPTSDTCGFTRFPGAPF--TNYMSYTDdnCTDNFTPNQVARMHCY 829
Cdd:pfam05572   93 --------------GEGDKVPDT------PSYTGGEVSLRNKDLFNCNGEPInsQNQMDYNG--CYAMFTQDQVDRMVEV 150


                   ..
gi 2462512252  830 LD 831
Cdd:pfam05572  151 LA 152
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1525-1591 1.21e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.38  E-value: 1.21e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462512252 1525 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYVAESAEgkvrnkllkIQCLEGGIW--EQGSCI 1591
Cdd:cd00033      1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST---------ITCTENGGWspPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
1525-1588 2.28e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 43.64  E-value: 2.28e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462512252 1525 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYvaesaegkvRNKLLKIQCLEGGIWEQG 1588
Cdd:pfam00084    1 CPPPPDIPNGKV---SATKNEYNYGASVSYECDPGYR---------LVGSPTITCQEDGTWSPP 52
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1722-1758 3.02e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.70  E-value: 3.02e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2462512252  1722 PDPVLVHC-IQSCEPFQADGWCDTINNRAYCHYDGGDC 1758
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1525-1585 1.83e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.97  E-value: 1.83e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462512252  1525 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYVAESAEgkvrnkllkIQCLEGGIW 1585
Cdd:smart00032    1 CPPPPDIENGTV---TSSSGTYSYGDTVTYSCDPGYTLIGSST---------ITCLENGTW 49
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 585-612 3.10e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 39.62  E-value: 3.10e-04
                            10        20
                    ....*....|....*....|....*...
gi 2462512252   585 NCEpSKIGNDHCDPECEHPLTGYDGGDC 612
Cdd:smart00004   12 QCW-DKFGDGVCDEECNNAECLWDGGDC 38
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
 684-743 6.19e-04

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 42.79  E-value: 6.19e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462512252  684 LNIYFASSVREDLAGAATWPWDKDAVTHLGGIVLSPAYYG---MPG--HTDTMIHEVGHVLGLYH 743
Cdd:cd04277     65 IRFGNSSDPDGNTAGYAYYPGSGSGTAYGGDIWFNSSYDTnsdSPGsyGYQTIIHEIGHALGLEH 129
Sushi pfam00084
Sushi repeat (SCR repeat);
1467-1521 7.92e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 39.02  E-value: 7.92e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462512252 1467 PDPSLVNYANFSCSEGTKFLK-RCSISCVPPAKLQGlSPWLTCLEDGLWSLPEVYC 1521
Cdd:pfam00084    2 PPPPDIPNGKVSATKNEYNYGaSVSYECDPGYRLVG-SPTITCQEDGTWSPPFPEC 56
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 703-749 1.31e-03

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 41.33  E-value: 1.31e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462512252  703 PWDKDAVT---HLGGIVLSPAYYGMPGH--TDTMIHEVGHVLGLYHVFKGVS 749
Cdd:cd04268     65 PSQVDPLTgeiLLARVYLYSSFVEYSGArlRNTAEHELGHALGLRHNFAASD 116
LamG smart00282
Laminin G domain;
348-430 2.46e-03

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 40.02  E-value: 2.46e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252   348 KKATILISHSRYQPGTWTHVAATYDGRHMALYVDGTqvaSSLDQSGPLNSPFMASCRSLLLGG-------DSSEDGHYFR 420
Cdd:smart00282   45 GPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG---NRVSGESPGGLTILNLDGPLYLGGlpedlklPPLPVTPGFR 121

                            90
                    ....*....|
gi 2462512252   421 GHLGTLVFWS 430
Cdd:smart00282  122 GCIRNLKVNG 131
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1467-1522 6.16e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 36.67  E-value: 6.16e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462512252 1467 PDPSLVNYANFSCSEGT-KFLKRCSISCVPPAKLQGlSPWLTCLEDGLWSLPEVYCK 1522
Cdd:cd00033      2 PPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVG-SSTITCTENGGWSPPPPTCE 57
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 351-428 9.96e-03

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 38.17  E-value: 9.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512252  351 TILISHSRYQPGTWTHVAATYDGRHMALYVDGTQVASsldQSGPLNSPFMASCRSLLLGG-------DSSEDGHYFRGHL 423
Cdd:pfam02210   42 SLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS---SLPPGESLLLNLNGPLYLGGlppllllPALPVRAGFVGCI 118


                   ....*
gi 2462512252  424 GTLVF 428
Cdd:pfam02210  119 RDVRV 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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