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Conserved domains on  [gi|2462505229|ref|XP_054190665|]
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leucine-rich repeat-containing protein 71 isoform X13 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 9-120 1.33e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 85.23  E-value: 1.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505229   9 PALRKVSLEGNPLPEQSYH---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGY 85
Cdd:COG5238   236 KSLTTLDLSNNQIGDEGVIalaEALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIA 311

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462505229  86 IADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRA 120
Cdd:COG5238   312 LAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE 346
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 9-120 1.33e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 85.23  E-value: 1.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505229   9 PALRKVSLEGNPLPEQSYH---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGY 85
Cdd:COG5238   236 KSLTTLDLSNNQIGDEGVIalaEALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIA 311

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462505229  86 IADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRA 120
Cdd:COG5238   312 LAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE 346
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 9-122 4.00e-13

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 68.54  E-value: 4.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505229   9 PALRKVSLEGNPLPEQSYHKL---MALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGY 85
Cdd:cd00116   165 RDLKELNLANNGIGDAGIRALaegLKANCNLEVLDLNNNGLTDEGASALAETLAS----LKSLEVLNLGDNNLTDAGAAA 240

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462505229  86 IADGLR-LNRSLLWLSLAHNRIQDKGALKLAEVLRAFE 122
Cdd:cd00116   241 LASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKE 278
LRR_6 pfam13516
Leucine Rich repeat;
65-87 3.54e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.21  E-value: 3.54e-04
                          10        20
                  ....*....|....*....|...
gi 2462505229  65 NRTLVSLNLGFNHIGDEGAGYIA 87
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
93-120 7.07e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 7.07e-04
                           10        20
                   ....*....|....*....|....*...
gi 2462505229   93 NRSLLWLSLAHNRIQDKGALKLAEVLRA 120
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 9-120 1.33e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 85.23  E-value: 1.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505229   9 PALRKVSLEGNPLPEQSYH---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGY 85
Cdd:COG5238   236 KSLTTLDLSNNQIGDEGVIalaEALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIA 311

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462505229  86 IADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRA 120
Cdd:COG5238   312 LAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE 346
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-118 8.76e-14

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 70.97  E-value: 8.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505229   5 LEISPALRKVSLEGNPLPEQS---YHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDE 81
Cdd:COG5238   288 LQGNTTLTSLDLSVNRIGDEGaiaLAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE----NTTLHSLDLSDNQIGDE 363

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462505229  82 GAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVL 118
Cdd:COG5238   364 GAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 4-118 1.19e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 70.59  E-value: 1.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505229   4 SLEISPALRKVSLEGNPLPEQ---SYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGD 80
Cdd:COG5238   259 ALKNNTTVETLYLSGNQIGAEgaiALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG----NKTLHTLNLAYNGIGA 334

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462505229  81 EGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVL 118
Cdd:COG5238   335 QGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYL 372
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 35-119 2.17e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 69.82  E-value: 2.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505229  35 TIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKL 114
Cdd:COG5238   209 TVTTLWLKRNPIGDEGAEILAEALKG----NKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIAL 284


                  ....*
gi 2462505229 115 AEVLR 119
Cdd:COG5238   285 AKALQ 289
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 9-122 4.00e-13

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 68.54  E-value: 4.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505229   9 PALRKVSLEGNPLPEQSYHKL---MALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGY 85
Cdd:cd00116   165 RDLKELNLANNGIGDAGIRALaegLKANCNLEVLDLNNNGLTDEGASALAETLAS----LKSLEVLNLGDNNLTDAGAAA 240

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462505229  86 IADGLR-LNRSLLWLSLAHNRIQDKGALKLAEVLRAFE 122
Cdd:cd00116   241 LASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKE 278
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 8-121 2.60e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 63.14  E-value: 2.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505229   8 SPALRKVSLEGNPLPEQSYHKL-MALDSTIA--HLSLRNNNIDDRGAQLLGQALSTLhscNRTLVSLNLGFNHIGDEGAG 84
Cdd:cd00116   192 NCNLEVLDLNNNGLTDEGASALaETLASLKSleVLNLGDNNLTDAGAAALASALLSP---NISLLTLSLSCNDITDDGAK 268

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462505229  85 YIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRAF 121
Cdd:cd00116   269 DLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEP 305
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 3-119 1.12e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 61.22  E-value: 1.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505229   3 CSLEISPALRKVSLEGNPLPEQSYHKLMAL--DSTIAHLSLRNNNIDDRGAQLLGQAL---------------------- 58
Cdd:cd00116    75 QGLTKGCGLQELDLSDNALGPDGCGVLESLlrSSSLQELKLNNNGLGDRGLRLLAKGLkdlppaleklvlgrnrlegasc 154

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462505229  59 ---STLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 119
Cdd:cd00116   155 ealAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLA 218
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 32-119 1.64e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.26  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505229  32 LDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGA 111
Cdd:COG5238   178 QNNSVETVYLGCNQIGDEGIEELAEALTQ----NTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGV 253


                  ....*...
gi 2462505229 112 LKLAEVLR 119
Cdd:COG5238   254 IALAEALK 261
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 4-122 7.90e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.87  E-value: 7.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505229   4 SLEISPALRKVSLEGNPLPEQSYHKL---MALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGD 80
Cdd:COG5238   315 GLQGNKTLHTLNLAYNGIGAQGAIALakaLQENTTLHSLDLSDNQIGDEGAIALAKYLEG----NTTLRELNLGKNNIGK 390

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462505229  81 EGAGYIADGLRLNRsLLWLSLAHNRIQDKGALKLAEVLRAFE 122
Cdd:COG5238   391 QGAEALIDALQTNR-LHTLILDGNLIGAEAQQRLEQLLERIK 431
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 50-119 1.97e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 1.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505229  50 GAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 119
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALK 233
LRR_6 pfam13516
Leucine Rich repeat;
65-87 3.54e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.21  E-value: 3.54e-04
                          10        20
                  ....*....|....*....|...
gi 2462505229  65 NRTLVSLNLGFNHIGDEGAGYIA 87
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
93-120 7.07e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 7.07e-04
                           10        20
                   ....*....|....*....|....*...
gi 2462505229   93 NRSLLWLSLAHNRIQDKGALKLAEVLRA 120
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
65-91 3.68e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.31  E-value: 3.68e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462505229   65 NRTLVSLNLGFNHIGDEGAGYIADGLR 91
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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