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Conserved domains on  [gi|2462490206|ref|XP_054184875|]
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interferon regulatory factor 7 isoform X3 [Homo sapiens]

Protein Classification

IRF and IRF-3 domain-containing protein( domain architecture ID 10457094)

IRF and IRF-3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 26-137 3.95e-48

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


:

Pssm-ID: 459863  Cd Length: 106  Bit Score: 161.19  E-value: 3.95e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206  26 LFGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLS-EADARIFKAWAVARGRWPPSSrgggpppeaETAERAGW 104
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNqEEDAAIFKAWAVHTGKYREGV---------DKPDPATW 71

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462490206 105 KTNFRCALRSTRRFVMLRDNS-GDPADPHKVYAL 137
Cdd:pfam00605  72 KTNFRCALNKLPDFEEVKDRSkDDGSDPYKVYRI 105
IRF-3 super family cl11061
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 273-447 2.83e-46

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


The actual alignment was detected with superfamily member pfam10401:

Pssm-ID: 463076  Cd Length: 180  Bit Score: 158.96  E-value: 2.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206 273 LDVTIMYKGRTVLQKVVGHP-SCTFLYGPPDPAVR---ATDPQQVAFPSPAELPDQKQLRYTEELLRHVAPGLHLELRGP 348
Cdd:pfam10401   4 LEITFFYRGRLVLELTVSSPeGCRLSYGPPDPQVAlygPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLLLWVAGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206 349 QLWARRMGKCKVYWEVGGPPGSASPstpaCLLPRNCDTPIFDFRVFFQELVEFRaRQRRGSPRYTIYLGFGQDLSAGRPK 428
Cdd:pfam10401  84 GLYAKRLCQSRVFWSGPEAPGGDKP----NKLERDATVKLFDLAKFLRELILFQ-EGRGRSPDYTITLCFGEEWPDDKPR 158

                         170
                  ....*....|....*....
gi 2462490206 429 EKSLVLVKLEPWLCRVHLE 447
Cdd:pfam10401 159 EKKLITVQVVPLFARQLLE 177
 
Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 26-137 3.95e-48

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 161.19  E-value: 3.95e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206  26 LFGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLS-EADARIFKAWAVARGRWPPSSrgggpppeaETAERAGW 104
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNqEEDAAIFKAWAVHTGKYREGV---------DKPDPATW 71

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462490206 105 KTNFRCALRSTRRFVMLRDNS-GDPADPHKVYAL 137
Cdd:pfam00605  72 KTNFRCALNKLPDFEEVKDRSkDDGSDPYKVYRI 105
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 273-447 2.83e-46

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 158.96  E-value: 2.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206 273 LDVTIMYKGRTVLQKVVGHP-SCTFLYGPPDPAVR---ATDPQQVAFPSPAELPDQKQLRYTEELLRHVAPGLHLELRGP 348
Cdd:pfam10401   4 LEITFFYRGRLVLELTVSSPeGCRLSYGPPDPQVAlygPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLLLWVAGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206 349 QLWARRMGKCKVYWEVGGPPGSASPstpaCLLPRNCDTPIFDFRVFFQELVEFRaRQRRGSPRYTIYLGFGQDLSAGRPK 428
Cdd:pfam10401  84 GLYAKRLCQSRVFWSGPEAPGGDKP----NKLERDATVKLFDLAKFLRELILFQ-EGRGRSPDYTITLCFGEEWPDDKPR 158

                         170
                  ....*....|....*....
gi 2462490206 429 EKSLVLVKLEPWLCRVHLE 447
Cdd:pfam10401 159 EKKLITVQVVPLFARQLLE 177
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 27-140 2.70e-43

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 148.63  E-value: 2.70e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206   27 FGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDL-SEADARIFKAWAVARGRWPPSSRGGGPppeaetaerAGWK 105
Cdd:smart00348   2 LRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFdEERDAEIFKAYCVARGIYQPGGRSPDP---------KTWK 72

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462490206  106 TNFRCALRSTRRFVMLRDNSGDPADPHKVYALSRE 140
Cdd:smart00348  73 ARLRCALRKSRDFEEIKDASTDPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 24-137 4.46e-39

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 137.42  E-value: 4.46e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206  24 RVLFGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLSEADARIFKAWAVARGRWPPSsrgggpppeaETAERAG 103
Cdd:cd00103     1 KMRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHDVQEADAKIFKAWAVERGIYQPG----------GTPDPAE 70

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462490206 104 WKTNFRCALRSTRRFVMLRDNSGD-PADPHKVYAL 137
Cdd:cd00103    71 WKARLLCALRSSRGFEEVKDKSKDtPGDPHRVYRL 105
DWB smart00524
Domain B in dwarfin family proteins;
330-423 7.68e-04

Domain B in dwarfin family proteins;


Pssm-ID: 197770  Cd Length: 171  Bit Score: 40.37  E-value: 7.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206  330 TEELLRHVAPGLHLELRGPQLWARRMGKCKVYweVGGPPGSA---SPSTPACLLPRNCDTPIFDFRVFFQELVEFRARQR 406
Cdd:smart00524  53 TELIRKHIGKGVQLSYENGDVWLYNRSDSPIF--VQSPYLDEpggRTLDTVHKLPPGYSIKVFDMEKFAQLLARELAKGF 130

                           90       100
                   ....*....|....*....|....*
gi 2462490206  407 RGSPRYTIYL--------GFGQDLS 423
Cdd:smart00524 131 EGVYDLARMCtirisfvkGWGPDYS 155
 
Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 26-137 3.95e-48

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 161.19  E-value: 3.95e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206  26 LFGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLS-EADARIFKAWAVARGRWPPSSrgggpppeaETAERAGW 104
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNqEEDAAIFKAWAVHTGKYREGV---------DKPDPATW 71

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462490206 105 KTNFRCALRSTRRFVMLRDNS-GDPADPHKVYAL 137
Cdd:pfam00605  72 KTNFRCALNKLPDFEEVKDRSkDDGSDPYKVYRI 105
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 273-447 2.83e-46

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 158.96  E-value: 2.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206 273 LDVTIMYKGRTVLQKVVGHP-SCTFLYGPPDPAVR---ATDPQQVAFPSPAELPDQKQLRYTEELLRHVAPGLHLELRGP 348
Cdd:pfam10401   4 LEITFFYRGRLVLELTVSSPeGCRLSYGPPDPQVAlygPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLLLWVAGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206 349 QLWARRMGKCKVYWEVGGPPGSASPstpaCLLPRNCDTPIFDFRVFFQELVEFRaRQRRGSPRYTIYLGFGQDLSAGRPK 428
Cdd:pfam10401  84 GLYAKRLCQSRVFWSGPEAPGGDKP----NKLERDATVKLFDLAKFLRELILFQ-EGRGRSPDYTITLCFGEEWPDDKPR 158

                         170
                  ....*....|....*....
gi 2462490206 429 EKSLVLVKLEPWLCRVHLE 447
Cdd:pfam10401 159 EKKLITVQVVPLFARQLLE 177
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 27-140 2.70e-43

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 148.63  E-value: 2.70e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206   27 FGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDL-SEADARIFKAWAVARGRWPPSSRGGGPppeaetaerAGWK 105
Cdd:smart00348   2 LRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFdEERDAEIFKAYCVARGIYQPGGRSPDP---------KTWK 72

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462490206  106 TNFRCALRSTRRFVMLRDNSGDPADPHKVYALSRE 140
Cdd:smart00348  73 ARLRCALRKSRDFEEIKDASTDPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 24-137 4.46e-39

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 137.42  E-value: 4.46e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206  24 RVLFGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLSEADARIFKAWAVARGRWPPSsrgggpppeaETAERAG 103
Cdd:cd00103     1 KMRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHDVQEADAKIFKAWAVERGIYQPG----------GTPDPAE 70

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462490206 104 WKTNFRCALRSTRRFVMLRDNSGD-PADPHKVYAL 137
Cdd:cd00103    71 WKARLLCALRSSRGFEEVKDKSKDtPGDPHRVYRL 105
DWB smart00524
Domain B in dwarfin family proteins;
330-423 7.68e-04

Domain B in dwarfin family proteins;


Pssm-ID: 197770  Cd Length: 171  Bit Score: 40.37  E-value: 7.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490206  330 TEELLRHVAPGLHLELRGPQLWARRMGKCKVYweVGGPPGSA---SPSTPACLLPRNCDTPIFDFRVFFQELVEFRARQR 406
Cdd:smart00524  53 TELIRKHIGKGVQLSYENGDVWLYNRSDSPIF--VQSPYLDEpggRTLDTVHKLPPGYSIKVFDMEKFAQLLARELAKGF 130

                           90       100
                   ....*....|....*....|....*
gi 2462490206  407 RGSPRYTIYL--------GFGQDLS 423
Cdd:smart00524 131 EGVYDLARMCtirisfvkGWGPDYS 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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