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Conserved domains on  [gi|2462581153|ref|XP_054179796|]
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ankyrin repeat and EF-hand domain-containing protein 1 isoform X1 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  33435370|17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
312-492 1.51e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.86  E-value: 1.51e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 312 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVES 391
Cdd:COG0666    96 RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 392 GALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLK 471
Cdd:COG0666   176 GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255

                         170       180
                  ....*....|....*....|.
gi 2462581153 472 GKTPPILKTEGPEIKKEEELL 492
Cdd:COG0666   256 LLLAAAAGAALIVKLLLLALL 276
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-162 4.49e-17

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.92  E-value: 4.49e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153   1 MEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKY 80
Cdd:COG0666   125 HLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153  81 IAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGaKNPNPLWALRLHDWSVEREAFLREAFAVLDR 160
Cdd:COG0666   205 LLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDG-LTALLLAAAAGAALIVKLLLLALLLLAAALL 283


                  ..
gi 2462581153 161 GD 162
Cdd:COG0666   284 DL 285
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
312-492 1.51e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.86  E-value: 1.51e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 312 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVES 391
Cdd:COG0666    96 RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 392 GALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLK 471
Cdd:COG0666   176 GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255

                         170       180
                  ....*....|....*....|.
gi 2462581153 472 GKTPPILKTEGPEIKKEEELL 492
Cdd:COG0666   256 LLLAAAAGAALIVKLLLLALL 276
Ank_2 pfam12796
Ankyrin repeats (3 copies);
340-432 4.76e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 90.56  E-value: 4.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 340 LMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALidAASINNSTPLNRAIESCRLDTVK 419
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 2462581153 420 YLLDIGAKFQLEN 432
Cdd:pfam12796  79 LLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-162 4.49e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.92  E-value: 4.49e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153   1 MEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKY 80
Cdd:COG0666   125 HLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153  81 IAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGaKNPNPLWALRLHDWSVEREAFLREAFAVLDR 160
Cdd:COG0666   205 LLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDG-LTALLLAAAAGAALIVKLLLLALLLLAAALL 283


                  ..
gi 2462581153 161 GD 162
Cdd:COG0666   284 DL 285
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 312-496 1.60e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 78.85  E-value: 1.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 312 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVES 391
Cdd:PHA02874  133 KKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 392 GA--------------------------LIDAASINN-----STPLNRAIE-SCRLDTVKYLLDIGAKFQLENRKGHSAM 439
Cdd:PHA02874  213 GNhimnkckngftplhnaiihnrsaielLINNASINDqdidgSTPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPI 292

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462581153 440 DVAKAYADYriIDLIKEKLDNLPKPAENQKLKGKTppILktEGPEIKKEEELLSSIY 496
Cdd:PHA02874  293 DTAFKYINK--DPVIKDIIANAVLIKEADKLKDSD--FL--EHIEIKDNKEFSDFIK 343
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1-88 2.23e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 2.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153   1 MEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAY-NGDVGLisiNGNTPLHYAAMGGFADCCK 79
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHaDVNLKD---NGRTALHYAARSGHLEIVK 78


                  ....*....
gi 2462581153  80 YIAQRGCDL 88
Cdd:pfam12796  79 LLLEKGADI 87
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 10-145 2.24e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.98  E-value: 2.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153  10 EIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLK 89
Cdd:PHA02874  105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN 184

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462581153  90 WKNLDHKTP-RAVAKEGGFKAASKEIRRAERIANKLARpgakNPNPLWALRLHDWSV 145
Cdd:PHA02874  185 VKDNNGESPlHNAAEYGDYACIKLLIDHGNHIMNKCKN----GFTPLHNAIIHNRSA 237
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 335-364 1.21e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 44.89  E-value: 1.21e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462581153  335 YYKTPLMTACASGNIDVVKFLLEKGANVNA 364
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 316-447 3.90e-06

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.08  E-value: 3.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 316 LASLKKAFESGIPVDM-----KDNYYK--TPLMTACASGNIDVVKFLLEKGANVNAT---DNFLWT-----------PLH 374
Cdd:TIGR00870 101 LLHLLAAFRKSGPLELandqyTSEFTPgiTALHLAAHRQNYEIVKLLLERGASVPARacgDFFVKSqgvdsfyhgesPLN 180

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462581153 375 FACHAGQQDIVELLVESGALIDAA-SINNstplnraiescrldTVKYLLDIGAKFQLENRK-GHSAMDVAKAYAD 447
Cdd:TIGR00870 181 AAACLGSPSIVALLSEDPADILTAdSLGN--------------TLLHLLVMENEFKAEYEElSCQMYNFALSLLD 241
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 337-406 1.64e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 47.70  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 337 KTPLMTACASGNIDVVKFLLEKGANVN---AT--------DNFLW---TPLHFACHAGQQDIVELLVESGALIDAASINN 402
Cdd:cd22192    90 ETALHIAVVNQNLNLVRELIARGADVVsprATgtffrpgpKNLIYygeHPLSFAACVGNEEIVRLLIEHGADIRAQDSLG 169


                  ....
gi 2462581153 403 STPL 406
Cdd:cd22192   170 NTVL 173
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 61-88 1.60e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.11  E-value: 1.60e-04
                           10        20
                   ....*....|....*....|....*...
gi 2462581153   61 NGNTPLHYAAMGGFADCCKYIAQRGCDL 88
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
312-492 1.51e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.86  E-value: 1.51e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 312 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVES 391
Cdd:COG0666    96 RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 392 GALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLK 471
Cdd:COG0666   176 GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255

                         170       180
                  ....*....|....*....|.
gi 2462581153 472 GKTPPILKTEGPEIKKEEELL 492
Cdd:COG0666   256 LLLAAAAGAALIVKLLLLALL 276
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
307-457 2.86e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 2.86e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 307 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVE 386
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462581153 387 LLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 457
Cdd:COG0666   138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
324-471 2.23e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.83  E-value: 2.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 324 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNS 403
Cdd:COG0666   141 EAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK 220

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462581153 404 TPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLK 471
Cdd:COG0666   221 TALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
340-432 4.76e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 90.56  E-value: 4.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 340 LMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALidAASINNSTPLNRAIESCRLDTVK 419
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 2462581153 420 YLLDIGAKFQLEN 432
Cdd:pfam12796  79 LLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
312-439 1.48e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 92.32  E-value: 1.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 312 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVES 391
Cdd:COG0666   162 ANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462581153 392 GALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAM 439
Cdd:COG0666   242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
312-397 2.70e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.77  E-value: 2.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 312 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKgANVNATDNfLWTPLHFACHAGQQDIVELLVES 391
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLLLEK 83


                  ....*.
gi 2462581153 392 GALIDA 397
Cdd:pfam12796  84 GADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
297-453 3.86e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 82.31  E-value: 3.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 297 IDDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFA 376
Cdd:COG0666    15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAA 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462581153 377 CHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDL 453
Cdd:COG0666    95 ARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKL 171
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-162 4.49e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.92  E-value: 4.49e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153   1 MEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKY 80
Cdd:COG0666   125 HLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153  81 IAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGaKNPNPLWALRLHDWSVEREAFLREAFAVLDR 160
Cdd:COG0666   205 LLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDG-LTALLLAAAAGAALIVKLLLLALLLLAAALL 283


                  ..
gi 2462581153 161 GD 162
Cdd:COG0666   284 DL 285
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-138 1.32e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 77.69  E-value: 1.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153   1 MEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKY 80
Cdd:COG0666    92 HAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKL 171

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462581153  81 IAQRGCDLKWKNLDHKTPRAVAKEGGFKAAskeirrAERIANKLARPGAKNPNPLWAL 138
Cdd:COG0666   172 LLEAGADVNARDNDGETPLHLAAENGHLEI------VKLLLEAGADVNAKDNDGKTAL 223
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 312-496 1.60e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 78.85  E-value: 1.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 312 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVES 391
Cdd:PHA02874  133 KKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 392 GA--------------------------LIDAASINN-----STPLNRAIE-SCRLDTVKYLLDIGAKFQLENRKGHSAM 439
Cdd:PHA02874  213 GNhimnkckngftplhnaiihnrsaielLINNASINDqdidgSTPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPI 292

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462581153 440 DVAKAYADYriIDLIKEKLDNLPKPAENQKLKGKTppILktEGPEIKKEEELLSSIY 496
Cdd:PHA02874  293 DTAFKYINK--DPVIKDIIANAVLIKEADKLKDSD--FL--EHIEIKDNKEFSDFIK 343
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1-88 2.23e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 2.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153   1 MEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAY-NGDVGLisiNGNTPLHYAAMGGFADCCK 79
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHaDVNLKD---NGRTALHYAARSGHLEIVK 78


                  ....*....
gi 2462581153  80 YIAQRGCDL 88
Cdd:pfam12796  79 LLLEKGADI 87
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 316-453 9.94e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 76.63  E-value: 9.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 316 LASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQ-----QDIVELLVE 390
Cdd:PHA03100   15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLE 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462581153 391 SGALIDAASINNSTPLNRAI--ESCRLDTVKYLLDIGAKFQLENRKGHSAMdvaKAYADYRIIDL 453
Cdd:PHA03100   95 YGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLL---HLYLESNKIDL 156
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 306-407 2.16e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 75.47  E-value: 2.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 306 NINIITKagdlasLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIV 385
Cdd:PHA03100  168 DINAKNR------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIF 241

                          90       100
                  ....*....|....*....|....*.
gi 2462581153 386 ELLVESGALIDA----ASINNSTPLN 407
Cdd:PHA03100  242 KLLLNNGPSIKTiietLLYFKDKDLN 267
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 318-475 3.04e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 75.00  E-value: 3.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 318 SLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 397
Cdd:PHA02874  106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462581153 398 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNlpkpaeNQKLKGKTP 475
Cdd:PHA02874  186 KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINNASIN------DQDIDGSTP 257
Ank_4 pfam13637
Ankyrin repeats (many copies);
338-389 2.33e-13

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 64.60  E-value: 2.33e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462581153 338 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLV 389
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 307-462 6.00e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.85  E-value: 6.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 307 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPL--MTACASGNIDVVKFLLEKGANVNATDNflwtplhfachagqqdi 384
Cdd:PHA03100  112 YAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLhlYLESNKIDLKILKLLIDKGVDINAKNR----------------- 174

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462581153 385 VELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAkayADYRIIDLIKEKLDNLP 462
Cdd:PHA03100  175 VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA---ILNNNKEIFKLLLNNGP 249
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-131 6.41e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.60  E-value: 6.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153   1 MEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKY 80
Cdd:COG0666   158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKL 237

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462581153  81 IAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKN 131
Cdd:COG0666   238 LLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
PHA03095 PHA03095
ankyrin-like protein; Provisional
 324-427 4.74e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 4.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 324 ESGIPVDMKDNYYKTPLMT-ACASGNIDVVKFLLEKGANVNATDNFLWTPLHfACHAGQQ---DIVELLVESGALIDAAS 399
Cdd:PHA03095   71 EAGADVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLH-VYLSGFNinpKVIRLLLRKGADVNALD 149

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462581153 400 INNSTPLNRAIES--CRLDTVKYLLDIGAK 427
Cdd:PHA03095  150 LYGMTPLAVLLKSrnANVELLRLLIDAGAD 179
PHA03095 PHA03095
ankyrin-like protein; Provisional
 329-475 3.64e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.43  E-value: 3.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 329 VDMKDNYYKTPLMTACASGNID--VVKFLLEKGANVNATDNFLWTPLH--FACHAGQQDIVELLVESGALIDAASINNST 404
Cdd:PHA03095  110 VNAKDKVGRTPLHVYLSGFNINpkVIRLLLRKGADVNALDLYGMTPLAvlLKSRNANVELLRLLIDAGADVYAVDDRFRS 189

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462581153 405 PLNRAIESCRLDT--VKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENqkLKGKTP 475
Cdd:PHA03095  190 LLHHHLQSFKPRAriVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLLIAGISINARN--RYGQTP 260
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 323-426 5.38e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 64.90  E-value: 5.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 323 FESGIPVDMKD-NYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASIN 401
Cdd:PHA02878  154 LSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKC 233

                          90       100
                  ....*....|....*....|....*.
gi 2462581153 402 NSTPLNRAIESCR-LDTVKYLLDIGA 426
Cdd:PHA02878  234 GNTPLHISVGYCKdYDILKLLLEHGV 259
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 323-445 1.74e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.93  E-value: 1.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 323 FESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFA-CHAGQQDIVELLVESGALIDAASIN 401
Cdd:PHA02876  362 LELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKD 441

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462581153 402 NSTPLNRAIE-SCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAY 445
Cdd:PHA02876  442 LSTPLHYACKkNCKLDVIEMLLDNGADVNAINIQNQYPLLIALEY 486
PHA03095 PHA03095
ankyrin-like protein; Provisional
 349-426 1.98e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.12  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 349 IDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQ---DIVELLVESGALIDAASINNSTPLNRAIES-CRLDTVKYLLDI 424
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLHLYLYNaTTLDVIKLLIKA 106


                  ..
gi 2462581153 425 GA 426
Cdd:PHA03095  107 GA 108
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 348-475 3.80e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 62.29  E-value: 3.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 348 NIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAK 427
Cdd:PHA02874  103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462581153 428 FQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENqklkGKTP 475
Cdd:PHA02874  183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKN----GFTP 226
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 350-457 6.70e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 61.43  E-value: 6.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 350 DVVKFLLEKGANVNATD-NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKF 428
Cdd:PHA02878  148 EITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462581153 429 QLENRKGHSAMDVAKAYA-DYRIIDLIKEK 457
Cdd:PHA02878  228 DARDKCGNTPLHISVGYCkDYDILKLLLEH 257
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 10-145 2.24e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.98  E-value: 2.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153  10 EIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLK 89
Cdd:PHA02874  105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN 184

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462581153  90 WKNLDHKTP-RAVAKEGGFKAASKEIRRAERIANKLARpgakNPNPLWALRLHDWSV 145
Cdd:PHA02874  185 VKDNNGESPlHNAAEYGDYACIKLLIDHGNHIMNKCKN----GFTPLHNAIIHNRSA 237
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-98 2.24e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.81  E-value: 2.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153   1 MEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKY 80
Cdd:COG0666    59 LAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKL 138

                          90
                  ....*....|....*...
gi 2462581153  81 IAQRGCDLKWKNLDHKTP 98
Cdd:COG0666   139 LLEAGADVNAQDNDGNTP 156
Ank_4 pfam13637
Ankyrin repeats (many copies);
370-422 5.84e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.28  E-value: 5.84e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462581153 370 WTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLL 422
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 292-445 6.28e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 58.46  E-value: 6.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 292 DSVWYIDDS--EKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFL 369
Cdd:PHA02875   89 DLGKFADDVfyKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCG 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 370 WTPLHFACHAGQQDIVELLVESGALIDAASINNS-TPLNRAIESCRLDTVKYLLDIGAK----FQLENRKgHSAMDVAKA 444
Cdd:PHA02875  169 CTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADcnimFMIEGEE-CTILDMICN 247


                  .
gi 2462581153 445 Y 445
Cdd:PHA02875  248 M 248
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 344-440 6.91e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.54  E-value: 6.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 344 CASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAG-QQDIVELLVESGALIDAASINNSTPLNRAIESCRLdtVKYLL 422
Cdd:PHA02876  417 CGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGI--VNILL 494

                          90
                  ....*....|....*...
gi 2462581153 423 DIGAKFQlENRKGHSAMD 440
Cdd:PHA02876  495 HYGAELR-DSRVLHKSLN 511
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 351-423 1.86e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.38  E-value: 1.86e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462581153 351 VVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLD 423
Cdd:PHA02876  160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
316-457 1.97e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.12  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 316 LASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALI 395
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462581153 396 DAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 457
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 321-442 2.10e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.00  E-value: 2.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 321 KAFESGIPVDMKDNYYKTPLMTACASG-NIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQ-QDIVELLVESGALIDAA 398
Cdd:PHA02876  292 KLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDRnKDIVITLLELGANVNAR 371

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462581153 399 SINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA 442
Cdd:PHA02876  372 DYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA 415
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 314-435 2.82e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.15  E-value: 2.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 314 GDLASLKKAFESGIPVDmkDNYYK---TPLMTACASGNIDVVKFLLEKGAN--VNATDNFlwTPLHFACHAGQQDIVELL 388
Cdd:PHA02875   79 GDVKAVEELLDLGKFAD--DVFYKdgmTPLHLATILKKLDIMKLLIARGADpdIPNTDKF--SPLHLAVMMGDIKGIELL 154

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2462581153 389 VESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKG 435
Cdd:PHA02875  155 IDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNG 201
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 3-98 2.82e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.13  E-value: 2.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153   3 ASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIA 82
Cdd:PHA02874  131 AIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI 210

                          90
                  ....*....|....*.
gi 2462581153  83 QRGCDLKWKNLDHKTP 98
Cdd:PHA02874  211 DHGNHIMNKCKNGFTP 226
Ank_5 pfam13857
Ankyrin repeats (many copies);
327-376 4.71e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 49.65  E-value: 4.71e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462581153 327 IPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFA 376
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 338-457 8.00e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.97  E-value: 8.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 338 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESG---ALIDAASINN------------ 402
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGvdtSILPIPCIEKdmiktildcgid 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462581153 403 --------STPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 457
Cdd:PHA02874  117 vnikdaelKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEK 179
Ank_2 pfam12796
Ankyrin repeats (3 copies);
327-366 8.55e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 8.55e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462581153 327 IPVDMKDNYYkTPLMTACASGNIDVVKFLLEKGANVNATD 366
Cdd:pfam12796  53 ADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 319-410 9.43e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.89  E-value: 9.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 319 LKKAFESGIPVDMKDNYYKTPLMTACAS-GNIDVVKFLLEKGANVNATDNFL-WTPLHFACHAgqQDIVELLVESGALID 396
Cdd:PHA02878  217 VHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILgLTALHSSIKS--ERKLKLLLEYGADIN 294

                          90
                  ....*....|....
gi 2462581153 397 AASINNSTPLNRAI 410
Cdd:PHA02878  295 SLNSYKLTPLSSAV 308
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 313-388 9.83e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.90  E-value: 9.83e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462581153 313 AGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELL 388
Cdd:PTZ00322   92 SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
Ank_4 pfam13637
Ankyrin repeats (many copies);
29-80 1.77e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.04  E-value: 1.77e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462581153  29 RHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKY 80
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKL 52
Ank_5 pfam13857
Ankyrin repeats (many copies);
355-409 3.41e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.34  E-value: 3.41e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462581153 355 LLEKG-ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRA 409
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 345-422 4.01e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.98  E-value: 4.01e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462581153 345 ASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLL 422
Cdd:PTZ00322   91 ASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 304-450 5.13e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 52.30  E-value: 5.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 304 FSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNatDNFL---WTPLHFACHAG 380
Cdd:PHA02875   36 ISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFAD--DVFYkdgMTPLHLATILK 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 381 QQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRI 450
Cdd:PHA02875  114 KLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAI 183
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 338-367 5.53e-07

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 46.13  E-value: 5.53e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2462581153 338 TPLMTACAS-GNIDVVKFLLEKGANVNATDN 367
Cdd:pfam00023   4 TPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 335-364 1.10e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 44.94  E-value: 1.10e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462581153 335 YYKTPLMTACASGNIDVVKFLLEKGANVNA 364
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 335-364 1.21e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 44.89  E-value: 1.21e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462581153  335 YYKTPLMTACASGNIDVVKFLLEKGANVNA 364
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
15-69 1.39e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 1.39e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462581153  15 ILERGGE-VNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYA 69
Cdd:pfam13857   1 LLEHGPIdLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 316-447 3.90e-06

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.08  E-value: 3.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 316 LASLKKAFESGIPVDM-----KDNYYK--TPLMTACASGNIDVVKFLLEKGANVNAT---DNFLWT-----------PLH 374
Cdd:TIGR00870 101 LLHLLAAFRKSGPLELandqyTSEFTPgiTALHLAAHRQNYEIVKLLLERGASVPARacgDFFVKSqgvdsfyhgesPLN 180

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462581153 375 FACHAGQQDIVELLVESGALIDAA-SINNstplnraiescrldTVKYLLDIGAKFQLENRK-GHSAMDVAKAYAD 447
Cdd:TIGR00870 181 AAACLGSPSIVALLSEDPADILTAdSLGN--------------TLLHLLVMENEFKAEYEElSCQMYNFALSLLD 241
PHA03095 PHA03095
ankyrin-like protein; Provisional
 319-422 4.12e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.64  E-value: 4.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 319 LKKAFESGIPVDMKDNYYKTPL--MTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALID 396
Cdd:PHA03095  205 VRELIRAGCDPAATDMLGNTPLhsMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADIN 284

                          90       100
                  ....*....|....*....|....*.
gi 2462581153 397 AASINNSTPLNRAIESCRLDTVKYLL 422
Cdd:PHA03095  285 AVSSDGNTPLSLMVRNNNGRAVRAAL 310
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 315-463 4.82e-06

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 49.53  E-value: 4.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 315 DLASLKKAFESGIPVDMKDNYYKTPLMTACASGNI--DVVKFLLEKGANVNATDNFLWTPLHfaCHAGQQDIVELLvesg 392
Cdd:PHA02716  296 DISVVYSFLQPGVKLHYKDSAGRTCLHQYILRHNIstDIIKLLHEYGNDLNEPDNIGNTVLH--TYLSMLSVVNIL---- 369

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462581153 393 alidAASINNSTplnraiescRLDTVKYLLDIGAKFQLENRKGHSAMD----VAKAYADYRIID-LIKEKLDNLPK 463
Cdd:PHA02716  370 ----DPETDNDI---------RLDVIQCLISLGADITAVNCLGYTPLTsyicTAQNYMYYDIIDcLISDKVLNMVK 432
PHA02798 PHA02798
ankyrin-like protein; Provisional
 349-459 7.44e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 48.68  E-value: 7.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 349 IDVVKFLLEKGANVNATDNFLWTPL-----HFACHAGQQDIVELLVESGALIDAASINNSTPL-----NRAIEScrLDTV 418
Cdd:PHA02798   51 TDIVKLFINLGANVNGLDNEYSTPLctilsNIKDYKHMLDIVKILIENGADINKKNSDGETPLycllsNGYINN--LEIL 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462581153 419 KYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLD 459
Cdd:PHA02798  129 LFMIENGADTTLLDKDGFTMLQVYLQSNHHIDIEIIKLLLE 169
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 298-470 8.66e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 8.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 298 DDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFAC 377
Cdd:PLN03192  520 HDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAI 599

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 378 HAGQQDIVELLVESGALIDAASINNStpLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKA-----YADYRII- 451
Cdd:PLN03192  600 SAKHHKIFRILYHFASISDPHAAGDL--LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAedhvdMVRLLIMn 677

                         170       180
                  ....*....|....*....|.
gi 2462581153 452 --DLIKEKLDNLPKPAENQKL 470
Cdd:PLN03192  678 gaDVDKANTDDDFSPTELREL 698
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 315-426 1.07e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.52  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 315 DLASLKKAFESGIPVDMKDNYYKTPLMTACASGNID-VVKFLLEKGANVNATDNFLWTPLHFACHAG-QQDIVELLVESG 392
Cdd:PHA02876  252 DLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLG 331

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462581153 393 ALIDAASINNSTPLNRAIESCRL-DTVKYLLDIGA 426
Cdd:PHA02876  332 ADVNAADRLYITPLHQASTLDRNkDIVITLLELGA 366
Ank_4 pfam13637
Ankyrin repeats (many copies);
312-356 1.29e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 1.29e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2462581153 312 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLL 356
Cdd:pfam13637  10 ASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02798 PHA02798
ankyrin-like protein; Provisional
 326-460 1.46e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 47.91  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 326 GIPVDMKDNYYKTPLMTACAS-----GNIDVVKFLLEKGANVNATDNFLWTPLHFACHAG---QQDIVELLVESGALIDA 397
Cdd:PHA02798   61 GANVNGLDNEYSTPLCTILSNikdykHMLDIVKILIENGADINKKNSDGETPLYCLLSNGyinNLEILLFMIENGADTTL 140

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462581153 398 ASINNSTPLNRAIES---CRLDTVKYLLDIGAKF-QLENRKGHSAMDVAKAYADYRI-IDLIKEKLDN 460
Cdd:PHA02798  141 LDKDGFTMLQVYLQSnhhIDIEIIKLLLEKGVDInTHNNKEKYDTLHCYFKYNIDRIdADILKLFVDN 208
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 337-406 1.64e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 47.70  E-value: 1.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 337 KTPLMTACASGNIDVVKFLLEKGANVN---AT--------DNFLW---TPLHFACHAGQQDIVELLVESGALIDAASINN 402
Cdd:cd22192    90 ETALHIAVVNQNLNLVRELIARGADVVsprATgtffrpgpKNLIYygeHPLSFAACVGNEEIVRLLIEHGADIRAQDSLG 169


                  ....
gi 2462581153 403 STPL 406
Cdd:cd22192   170 NTVL 173
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 10-98 6.51e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.43  E-value: 6.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153  10 EIVRGILERGGEVNAFDNDRHHAAHFAAKGGF--FDILKLLFAYNGDVG-------LIS---------INGNTPLHYAAM 71
Cdd:PHA03100  122 SIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINaknrvnyLLSygvpinikdVYGFTPLHYAVY 201

                          90       100
                  ....*....|....*....|....*..
gi 2462581153  72 GGFADCCKYIAQRGCDLKWKNLDHKTP 98
Cdd:PHA03100  202 NNNPEFVKYLLDLGANPNLVNKYGDTP 228
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 317-413 7.08e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 44.97  E-value: 7.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 317 ASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFL-WTPLHFACHAGQQDIVELLVESGALI 395
Cdd:PHA02884   51 AILKLGADPEAPFPLSENSKTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAkITPLYISVLHGCLKCLEILLSYGADI 130

                          90
                  ....*....|....*...
gi 2462581153 396 DAASINNSTPLNRAIESC 413
Cdd:PHA02884  131 NIQTNDMVTPIELALMIC 148
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 340-411 7.14e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.01  E-value: 7.14e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462581153 340 LMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINN---STPLNRAIE 411
Cdd:PLN03192  626 LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDdfsPTELRELLQ 700
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 339-454 7.71e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 45.64  E-value: 7.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 339 PLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFAC-HAGQQDIVELLVE------SGAL--IDAASINNSTPL--- 406
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkEPNKLGMKEMIRSinkcsvFYTLvaIKDAFNNRNVEIfki 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462581153 407 --------NRAIESCRLDT-----------VKYLLDIGAKFQLENR-KGHSAMDVAKAYADYRIIDLI 454
Cdd:PHA02878  120 iltnryknIQTIDLVYIDKkskddiieaeiTKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELL 187
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 370-397 1.11e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.58  E-value: 1.11e-04
                          10        20
                  ....*....|....*....|....*....
gi 2462581153 370 WTPLHFAC-HAGQQDIVELLVESGALIDA 397
Cdd:pfam00023   3 NTPLHLAAgRRGNLEIVKLLLSKGADVNA 31
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 323-425 1.59e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.67  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 323 FESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVN--ATDNFlwTPLHFACHAGQQDIVELLVESGALIDaasi 400
Cdd:PHA02876  165 LEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNiiALDDL--SVLECAVDSKNIDTIKAIIDNRSNIN---- 238

                          90       100
                  ....*....|....*....|....*
gi 2462581153 401 NNSTPLNRAIESCRLDTVKYLLDIG 425
Cdd:PHA02876  239 KNDLSLLKAIRNEDLETSLLLYDAG 263
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 61-88 1.60e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.11  E-value: 1.60e-04
                           10        20
                   ....*....|....*....|....*...
gi 2462581153   61 NGNTPLHYAAMGGFADCCKYIAQRGCDL 88
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 318-393 3.07e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.90  E-value: 3.07e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462581153 318 SLKKAFESGIPVDMKDNYYKTPLMTACASG-NIDVVKFLLEKGANVNATDNFLWTPLHFAChaGQQDIVELLVESGA 393
Cdd:PHA02876  424 SVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGA 498
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 314-454 3.13e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.44  E-value: 3.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 314 GDLASLKKAFESGIP--VDMKDNYykTPLMTACASGNIDVVKFLLEKGA--NVNATDnfLWTPLHFACHAGQQDIVELLV 389
Cdd:PHA02875   13 GELDIARRLLDIGINpnFEIYDGI--SPIKLAMKFRDSEAIKLLMKHGAipDVKYPD--IESELHDAVEEGDVKAVEELL 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462581153 390 ESGALI-DAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLI 454
Cdd:PHA02875   89 DLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 331-469 3.17e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 43.72  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 331 MKDNYYK--TPLMTACASGNIDVVKFLLEKGANVNATDN-------------FLWTPLHFACHAGQQDIVELLVESGALI 395
Cdd:cd21882    66 CTDEFYQgqTALHIAIENRNLNLVRLLVENGADVSARATgrffrkspgnlfyFGELPLSLAACTNQEEIVRLLLENGAQP 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 396 DAASINNS---TPL-------NRAIESCRLDTVKY--LLDIGAKF----QLE---NRKGHSAMDVAKAYADYRIIDLIKE 456
Cdd:cd21882   146 AALEAQDSlgnTVLhalvlqaDNTPENSAFVCQMYnlLLSYGAHLdptqQLEeipNHQGLTPLKLAAVEGKIVMFQHILQ 225

                         170
                  ....*....|...
gi 2462581153 457 KLDNLPKPAENQK 469
Cdd:cd21882   226 REFSGPYQPLSRK 238
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 61-88 8.36e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 8.36e-04
                          10        20
                  ....*....|....*....|....*...
gi 2462581153  61 NGNTPLHYAAMGGFADCCKYIAQRGCDL 88
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 61-92 8.46e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 8.46e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462581153  61 NGNTPLHYAA-MGGFADCCKYIAQRGCDLKWKN 92
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 10-98 8.63e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.17  E-value: 8.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153  10 EIVRGILERGGEVNAFDNDRHHAA-HFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDL 88
Cdd:PHA02878  148 EITKLLLSYGADINMKDRHKGNTAlHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                          90
                  ....*....|
gi 2462581153  89 KWKNLDHKTP 98
Cdd:PHA02878  228 DARDKCGNTP 237
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 305-406 1.10e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.97  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 305 SNINIITkAGDLASLKKAFESG------IPVDMKDNYYKT--PLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFA 376
Cdd:PHA02876  202 ADVNIIA-LDDLSVLECAVDSKnidtikAIIDNRSNINKNdlSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHA 280

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462581153 377 CHAGQ-QDIVELLVESGALIDAASINNSTPL 406
Cdd:PHA02876  281 SQAPSlSRLVPKLLERGADVNAKNIKGETPL 311
Ank_4 pfam13637
Ankyrin repeats (many copies);
3-48 1.58e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462581153   3 ASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLL 48
Cdd:pfam13637   8 AAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 370-397 1.93e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 1.93e-03
                           10        20
                   ....*....|....*....|....*...
gi 2462581153  370 WTPLHFACHAGQQDIVELLVESGALIDA 397
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 349-475 2.59e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 40.49  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 349 IDVVKFLLEKGANVNATdNFLWTPL-------HFACHAGQQdIVELLVESGALIDAASINNSTPL-----NRAIESCrlD 416
Cdd:PHA02989   50 IKIVKLLIDNGADVNYK-GYIETPLcavlrnrEITSNKIKK-IVKLLLKFGADINLKTFNGVSPIvcfiyNSNINNC--D 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462581153 417 TVKYLLDIGAkfQLENRKGHSAMDVAKAYADYRII--DLIKEKLDNLPKPAENQKLKGKTP 475
Cdd:PHA02989  126 MLRFLLSKGI--NVNDVKNSRGYNLLHMYLESFSVkkDVIKILLSFGVNLFEKTSLYGLTP 184
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 319-440 3.30e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 40.11  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 319 LKKAFESGIPVDMKDNYYKTPLMTACASGNI---DVVKFLLEKGANVNATDNFL-WTPLH--FACHAGQQDIVELLVESG 392
Cdd:PHA02989   91 VKLLLKFGADINLKTFNGVSPIVCFIYNSNInncDMLRFLLSKGINVNDVKNSRgYNLLHmyLESFSVKKDVIKILLSFG 170

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462581153 393 A-LIDAASINNSTPLN----RAIESCRLDTVKYLLDIGAKFQLENRKGHSAMD 440
Cdd:PHA02989  171 VnLFEKTSLYGLTPMNiylrNDIDVISIKVIKYLIKKGVNIETNNNGSESVLE 223
Ank_2 pfam12796
Ankyrin repeats (3 copies);
66-107 3.59e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 3.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462581153  66 LHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGF 107
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGH 42
PHA02798 PHA02798
ankyrin-like protein; Provisional
 303-434 3.88e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.20  E-value: 3.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 303 VFSNINIITKAGDLASLkkAFESGIPVDMKDNYYKTPLMTACASG---NIDVVKFLLEKGANVNATDNFLWTPLHFACHA 379
Cdd:PHA02798   78 ILSNIKDYKHMLDIVKI--LIENGADINKKNSDGETPLYCLLSNGyinNLEILLFMIENGADTTLLDKDGFTMLQVYLQS 155

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462581153 380 G---QQDIVELLVESGalIDAASINNSTPLN-------RAIESCRLDTVKYLLDIG---AKFQLENRK 434
Cdd:PHA02798  156 NhhiDIEIIKLLLEKG--VDINTHNNKEKYDtlhcyfkYNIDRIDADILKLFVDNGfiiNKENKSHKK 221
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 340-425 4.04e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 39.95  E-value: 4.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581153 340 LMTACASGNIDVVKFLLEKGAN-VNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTV 418
Cdd:PHA02874    5 LRMCIYSGDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDII 84


                  ....*..
gi 2462581153 419 KYLLDIG 425
Cdd:PHA02874   85 KLLIDNG 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 3-69 4.76e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 39.56  E-value: 4.76e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462581153   3 ASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYA 69
Cdd:PHA02874  164 AIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 12-76 6.50e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 6.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462581153  12 VRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFAD 76
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFRE 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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