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Conserved domains on  [gi|2217328599|ref|XP_047300600|]
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cysteine-rich motor neuron 1 protein isoform X10 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 775-904 1.30e-77

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


:

Pssm-ID: 437274  Cd Length: 130  Bit Score: 248.23  E-value: 1.30e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328599 775 ENDIVHLPRDMGHLQVDYRD-NRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCwYRTPTKPSSLNNQ 853
Cdd:pfam19442   1 ENDIVHQPRDMGHLQVDYREgSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217328599 854 LVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 904
Cdd:pfam19442  80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
39-90 6.74e-07

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 46.93  E-value: 6.74e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217328599  39 PCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTfgiYGTCDRGLRC 90
Cdd:pfam00219   4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVY---TPPCGKGLRC 53
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 625-676 3.15e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 45.11  E-value: 3.15e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217328599 625 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 676
Cdd:pfam00093   4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 687-741 1.25e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 43.57  E-value: 1.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217328599 687 CHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEP--INVEGSCCPMC 741
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
345-398 4.46e-05

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.12  E-value: 4.46e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217328599  345 CYANGLILAHGDRWREDDCTFCQCVNGER-HCVATVC--GQTCTNP--VKVPGECCPVC 398
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
278-332 1.30e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.58  E-value: 1.30e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217328599  278 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAI-CFTAQCGE-INCERYY--VPEGECCPVC 332
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 509-534 2.82e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


:

Pssm-ID: 460713  Cd Length: 26  Bit Score: 38.69  E-value: 2.82e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217328599 509 CPELSCSKICPLGFQQDSHGCLICKC 534
Cdd:pfam02822   1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 554-604 1.84e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 37.40  E-value: 1.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217328599 554 DGHHHKNEESWH-DGCRECYCLNGREMCALITCPVPACGNPT--IHPGQCCPSC 604
Cdd:pfam00093   4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 775-904 1.30e-77

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 248.23  E-value: 1.30e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328599 775 ENDIVHLPRDMGHLQVDYRD-NRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCwYRTPTKPSSLNNQ 853
Cdd:pfam19442   1 ENDIVHQPRDMGHLQVDYREgSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217328599 854 LVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 904
Cdd:pfam19442  80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
39-90 6.74e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 46.93  E-value: 6.74e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217328599  39 PCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTfgiYGTCDRGLRC 90
Cdd:pfam00219   4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVY---TPPCGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 625-676 3.15e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.11  E-value: 3.15e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217328599 625 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 676
Cdd:pfam00093   4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 687-741 1.25e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.57  E-value: 1.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217328599 687 CHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEP--INVEGSCCPMC 741
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
345-398 4.46e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.12  E-value: 4.46e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217328599  345 CYANGLILAHGDRWREDDCTFCQCVNGER-HCVATVC--GQTCTNP--VKVPGECCPVC 398
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
625-676 1.08e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.08e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217328599  625 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCQNPSRTQ--DSCCPQC 676
Cdd:smart00214   4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
278-332 1.30e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.58  E-value: 1.30e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217328599  278 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAI-CFTAQCGE-INCERYY--VPEGECCPVC 332
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 278-332 2.81e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.81e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217328599 278 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCE--RYYVPEGECCPVC 332
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 509-534 2.82e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 38.69  E-value: 2.82e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217328599 509 CPELSCSKICPLGFQQDSHGCLICKC 534
Cdd:pfam02822   1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC smart00214
von Willebrand factor (vWF) type C domain;
687-741 3.51e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 3.51e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217328599  687 CHFSGKAYADEERWDLDSCTHCYCLQGQT-LCSTVSCPPLPCV---EPINVEGSCCPMC 741
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPPPPDCpnpERVKPPGECCPRC 59
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 37-95 1.20e-03

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 38.22  E-value: 1.20e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328599   37 CLPCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFgiyGTCDRGLRCVIRPP 95
Cdd:smart00121   3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPCGVYT---PRCAPGLRCQPPPG 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 554-604 1.84e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 1.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217328599 554 DGHHHKNEESWH-DGCRECYCLNGREMCALITCPVPACGNPT--IHPGQCCPSC 604
Cdd:pfam00093   4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 345-398 4.43e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 4.43e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217328599 345 CYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQ-TCTNP--VKVPGECCPVC 398
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPlDCPNPrlEIPPGECCPVC 57
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 775-904 1.30e-77

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 248.23  E-value: 1.30e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328599 775 ENDIVHLPRDMGHLQVDYRD-NRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCwYRTPTKPSSLNNQ 853
Cdd:pfam19442   1 ENDIVHQPRDMGHLQVDYREgSRPHPSEDSSLHSVAWVTVPIMIALVLIIALLLINQKKQWIPVPC-YRTPTKPSCLNNQ 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217328599 854 LVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQADNFYQTV 904
Cdd:pfam19442  80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQTV 130
IGFBP pfam00219
Insulin-like growth factor binding protein;
39-90 6.74e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 46.93  E-value: 6.74e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217328599  39 PCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTfgiYGTCDRGLRC 90
Cdd:pfam00219   4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVY---TPPCGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 625-676 3.15e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.11  E-value: 3.15e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217328599 625 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ--DSCCPQC 676
Cdd:pfam00093   4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 687-741 1.25e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.57  E-value: 1.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217328599 687 CHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEP--INVEGSCCPMC 741
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
345-398 4.46e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.12  E-value: 4.46e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217328599  345 CYANGLILAHGDRWREDDCTFCQCVNGER-HCVATVC--GQTCTNP--VKVPGECCPVC 398
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECppPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
625-676 1.08e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.96  E-value: 1.08e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217328599  625 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCQNPSRTQ--DSCCPQC 676
Cdd:smart00214   4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
278-332 1.30e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.58  E-value: 1.30e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217328599  278 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAI-CFTAQCGE-INCERYY--VPEGECCPVC 332
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 278-332 2.81e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.81e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217328599 278 CVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCE--RYYVPEGECCPVC 332
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 509-534 2.82e-04

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 38.69  E-value: 2.82e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217328599 509 CPELSCSKICPLGFQQDSHGCLICKC 534
Cdd:pfam02822   1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC smart00214
von Willebrand factor (vWF) type C domain;
687-741 3.51e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 3.51e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217328599  687 CHFSGKAYADEERWDLDSCTHCYCLQGQT-LCSTVSCPPLPCV---EPINVEGSCCPMC 741
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPPPPDCpnpERVKPPGECCPRC 59
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 37-95 1.20e-03

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 38.22  E-value: 1.20e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328599   37 CLPCDESKC-EEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFgiyGTCDRGLRCVIRPP 95
Cdd:smart00121   3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPCGVYT---PRCAPGLRCQPPPG 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 554-604 1.84e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 1.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217328599 554 DGHHHKNEESWH-DGCRECYCLNGREMCALITCPVPACGNPT--IHPGQCCPSC 604
Cdd:pfam00093   4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 695-741 2.64e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 41.22  E-value: 2.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217328599 695 ADEERWDLDSCTH---CYC---LQGQTLCSTVS--CPPLPCVEPINVEGSCCPMC 741
Cdd:pfam14828 181 AGALRVGPEACSDpsgCGCgndENLERICANVLqrCPPPHCLSPLRPEGHCCDVC 235
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 345-398 4.43e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 4.43e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217328599 345 CYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQ-TCTNP--VKVPGECCPVC 398
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPlDCPNPrlEIPPGECCPVC 57
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 362-398 5.88e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 40.06  E-value: 5.88e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2217328599 362 DCTFCQC---VNGERHC--VATVCGQ-TCTNPVKVPGECCPVC 398
Cdd:pfam14828 193 DPSGCGCgndENLERICanVLQRCPPpHCLSPLRPEGHCCDVC 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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