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Conserved domains on  [gi|2217375756|ref|XP_047278817|]
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uncharacterized protein KIAA2026 isoform X6 [Homo sapiens]

Protein Classification

bromodomain-containing protein( domain architecture ID 10137890)

bromodomain-containing protein binds acetylated lysines

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 137-193 3.29e-11

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


:

Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 60.46  E-value: 3.29e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217375756 137 MCLLQMEEKFASGQYGGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMMLEQKL 193
Cdd:cd04369    43 MDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSPIYKDAKKLEKLFEKLL 99
CCDC34 super family cl37875
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 250-288 1.25e-03

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


The actual alignment was detected with superfamily member pfam13904:

Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 41.23  E-value: 1.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217375756 250 QVLRQEEQLRAKEEKRLREQERKEAEEASQKEIEEWERK 288
Cdd:pfam13904  65 QRQRQKELQAQKEEREKEEQEAELRKRLAKEKYQEWLQR 103
 
Name Accession Description Interval E-value
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 137-193 3.29e-11

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 60.46  E-value: 3.29e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217375756 137 MCLLQMEEKFASGQYGGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMMLEQKL 193
Cdd:cd04369    43 MDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSPIYKDAKKLEKLFEKLL 99
BROMO smart00297
bromo domain;
137-196 1.24e-06

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 47.66  E-value: 1.24e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217375756  137 MCLLQMEEKFASGQYGGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMMLEQKLALL 196
Cdd:smart00297  48 MDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGPDSEVYKDAKKLEKFFEKKLREL 107
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 137-184 3.10e-05

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 43.07  E-value: 3.10e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2217375756 137 MCLLQMEEKFASGQYGGITEFVADFRLMLETCYRLHGVDHWISKQGQK 184
Cdd:pfam00439  37 MDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAAEK 84
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 137-186 3.28e-05

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 47.11  E-value: 3.28e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217375756 137 MCLLQMEEKFASGQYGGITEFVADFRLMLETCYRLHGVDHWISKQGQKLE 186
Cdd:COG5076   189 MDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELE 238
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 250-288 1.25e-03

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 41.23  E-value: 1.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217375756 250 QVLRQEEQLRAKEEKRLREQERKEAEEASQKEIEEWERK 288
Cdd:pfam13904  65 QRQRQKELQAQKEEREKEEQEAELRKRLAKEKYQEWLQR 103
 
Name Accession Description Interval E-value
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 137-193 3.29e-11

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 60.46  E-value: 3.29e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217375756 137 MCLLQMEEKFASGQYGGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMMLEQKL 193
Cdd:cd04369    43 MDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSPIYKDAKKLEKLFEKLL 99
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 137-193 2.69e-08

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 52.32  E-value: 2.69e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217375756 137 MCLLQMEEKFASGQYGGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMMLEQKL 193
Cdd:cd05500    47 MDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPEHPVSQMGKRLQAAFEKHL 103
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 78-193 2.17e-07

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 49.98  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217375756  78 ELQQGYRILGEFLQEKHRGLTAPFLQPLGGVATaeeevaegprsggrggrafpQQPG------QGMCLLQMEEKFASGQY 151
Cdd:cd05499     1 ELKFCEEVLKELMKPKHSAYNWPFLDPVDPVAL--------------------NIPNyfsiikKPMDLGTISKKLQNGQY 60

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2217375756 152 GGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMMLEQKL 193
Cdd:cd05499    61 QSAKEFERDVRLIFKNCYTFNPEGTDVYMMGHQLEEVFNDKW 102
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 83-192 2.21e-07

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 49.97  E-value: 2.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217375756  83 YRILGEFLQEKHRGLTAPFLQPLGGVATAEEEVAEGPrsggrggrafpQQPgqgMCLLQMEEKFASGQYGGITEFVADFR 162
Cdd:cd05498     6 SGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDII-----------KHP---MDLSTIKKKLDNREYADAQEFAADVR 71

                          90       100       110
                  ....*....|....*....|....*....|
gi 2217375756 163 LMLETCYRLHGVDHWISKQGQKLEMMLEQK 192
Cdd:cd05498    72 LMFSNCYKYNPPDHPVHAMARKLQDVFEDR 101
BROMO smart00297
bromo domain;
137-196 1.24e-06

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 47.66  E-value: 1.24e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217375756  137 MCLLQMEEKFASGQYGGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMMLEQKLALL 196
Cdd:smart00297  48 MDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGPDSEVYKDAKKLEKFFEKKLREL 107
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 137-193 2.49e-05

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 44.08  E-value: 2.49e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217375756 137 MCLLQMEEKFASGQYGGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMMLEQKL 193
Cdd:cd05509    42 MDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDTEYYKCANKLEKFFWKKL 98
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 137-184 3.10e-05

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 43.07  E-value: 3.10e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2217375756 137 MCLLQMEEKFASGQYGGITEFVADFRLMLETCYRLHGVDHWISKQGQK 184
Cdd:pfam00439  37 MDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAAEK 84
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 137-186 3.28e-05

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 47.11  E-value: 3.28e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217375756 137 MCLLQMEEKFASGQYGGITEFVADFRLMLETCYRLHGVDHWISKQGQKLE 186
Cdd:COG5076   189 MDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELE 238
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 140-196 2.59e-04

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 41.12  E-value: 2.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217375756 140 LQMEEkfaSGQYGGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMMLEQKLALL 196
Cdd:cd05502    53 LQPKS---PQHYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKELELFFEEQLKEI 106
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 250-288 1.25e-03

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 41.23  E-value: 1.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217375756 250 QVLRQEEQLRAKEEKRLREQERKEAEEASQKEIEEWERK 288
Cdd:pfam13904  65 QRQRQKELQAQKEEREKEEQEAELRKRLAKEKYQEWLQR 103
Selenoprotein_S pfam06936
Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) ...
 225-287 1.42e-03

Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types. Selenoprotein S (SelS) is an intrinsically disordered protein. It formsa selenosulfide bond between cys 174 and Sec 188, that has a redox potential -234 mV. In vitro, SelS is an efficient reductase that depends on the presence of selenocysteine. Due to the high reactivity, SelS also has peroxidase activity that can catalyze the reduction of hydrogen peroxide. It is also resistant to inactivation by hydrogen peroxide which might provide evolutionary advantage compared to cysteine containing peroxidases.


Pssm-ID: 462043 [Multi-domain]  Cd Length: 192  Bit Score: 40.98  E-value: 1.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217375756 225 TSTRRRSTPRSLAGLTSGVF----ESIMVQVLRQEEQLRAKEEKrLREQERKEAEEASQKEIEEWER 287
Cdd:pfam06936  59 TALRQRSSDHSAATVDPDLVvkrqEALEASRLRMQEELDAQAEK-FKEKQKQLEEEKRRQKIEMWES 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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