P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938938912  41 LLLFVDEVDAFpgkLRHREAtssvwpqevvgrEEINKDLKATQYAFLNHMKDRSNKFMLVLTS-HPEQLHWDIHDRIDVM 119
Cdd:cd19512    83 LLLFVDEADAF---LRKRST------------EKISEDLRAALNAFLYRTGEQSNKFMLVLASnQPEQFDWAINDRIDEM 147

                  ...
gi 1938938912 120 LHF 122
Cdd:cd19512   148 VEF 150

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938938912  41 LLLFVDEVDAFpgkLRHREAtssvwpqevvgrEEINKDLKATQYAFLNHMKDRSNKFMLVLTS-HPEQLHWDIHDRIDVM 119
Cdd:cd19512    83 LLLFVDEADAF---LRKRST------------EKISEDLRAALNAFLYRTGEQSNKFMLVLASnQPEQFDWAINDRIDEM 147

                  ...
gi 1938938912 120 LHF 122
Cdd:cd19512   148 VEF 150

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938938912  37 SSACLLLFVDEVDAfpgklrhreatssVWPQEVVGREEINKDLKATQYAFLNHMKDRSNKFMLVLTSH-PEQLHWDIHDR 115
Cdd:pfam00004  55 KLAPCVIFIDEIDA-------------LAGSRGSGGDSESRRVVNQLLTELDGFTSSNSKVIVIAATNrPDKLDPALLGR 121

                  ....*....
gi 1938938912 116 IDVMLHFDL 124
Cdd:pfam00004 122 FDRIIEFPL 130

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938938912  41 LLLFVDEVDAFpgkLRHREAtssvwpqevvgrEEINKDLKATQYAFLNHMKDRSNKFMLVLTS-HPEQLHWDIHDRIDVM 119
Cdd:cd19512    83 LLLFVDEADAF---LRKRST------------EKISEDLRAALNAFLYRTGEQSNKFMLVLASnQPEQFDWAINDRIDEM 147

                  ...
gi 1938938912 120 LHF 122
Cdd:cd19512   148 VEF 150

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938938912  37 SSACLLLFVDEVDAfpgklrhreatssVWPQEVVGREEINKDLKATQYAFLNHMKDRSNKFMLVLTSH-PEQLHWDIHDR 115
Cdd:pfam00004  55 KLAPCVIFIDEIDA-------------LAGSRGSGGDSESRRVVNQLLTELDGFTSSNSKVIVIAATNrPDKLDPALLGR 121

                  ....*....
gi 1938938912 116 IDVMLHFDL 124
Cdd:pfam00004 122 FDRIIEFPL 130