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Conserved domains on  [gi|1907068317|ref|XP_036019712|]
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DNA annealing helicase and endonuclease ZRANB3 isoform X5 [Mus musculus]

Protein Classification

SF2_C_SNF and HNHc domain-containing protein( domain architecture ID 13039469)

protein containing domains SF2_C_SNF, ZnF_RBZ, and HNHc

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 9-115 2.41e-42

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


:

Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 150.32  E-value: 2.41e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068317   9 KFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAAGQGLTFTAASHVVFAELYW 88
Cdd:cd18793    29 KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAGGVGLNLTAANRVILYDPWW 108

                          90       100
                  ....*....|....*....|....*..
gi 1907068317  89 DPGHIKQAEDRAHRIGQCSSVNIHYLI 115
Cdd:cd18793   109 NPAVEEQAIDRAHRIGQKKPVVVYRLI 135
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 690-755 1.30e-07

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


:

Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 49.01  E-value: 1.30e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907068317 690 KSHRKSLLNAAWTAKLPLEqlnemlrnPGEGHFWQVDHIRPVyEGGGQCSLDNLQTLCTVCHKERT 755
Cdd:cd00085     1 RSHRLVLLARDGLCPYCGK--------PGGTEGLEVDHIIPL-SDGGNNDLDNLVLLCRKCHRKKH 57
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 290-312 2.26e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


:

Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 36.14  E-value: 2.26e-03
                           10        20
                   ....*....|....*....|...
gi 1907068317  290 WQCGFCTFLNNPGLPYCEMCENP 312
Cdd:smart00547   3 WECPACTFLNFASRSKCFACGAP 25
 
Name Accession Description Interval E-value
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 9-115 2.41e-42

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 150.32  E-value: 2.41e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068317   9 KFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAAGQGLTFTAASHVVFAELYW 88
Cdd:cd18793    29 KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAGGVGLNLTAANRVILYDPWW 108

                          90       100
                  ....*....|....*....|....*..
gi 1907068317  89 DPGHIKQAEDRAHRIGQCSSVNIHYLI 115
Cdd:cd18793   109 NPAVEEQAIDRAHRIGQKKPVVVYRLI 135
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 9-133 4.14e-34

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 139.59  E-value: 4.14e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068317   9 KFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAAGQGLTFTAASHVVFAELYW 88
Cdd:COG0553   551 KVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWW 630

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1907068317  89 DPGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDSLMWAMLNRKAQ 133
Cdd:COG0553   631 NPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA 675
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 9-104 1.95e-14

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 69.93  E-value: 1.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068317   9 KFLVFAHHLSMLQaCTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVaILSIQAAGQGLTFTAASHVVFAELYW 88
Cdd:pfam00271  17 KVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDV-LVATDVAERGLDLPDVDLVINYDLPW 93

                          90
                  ....*....|....*.
gi 1907068317  89 DPGHIKQAEDRAHRIG 104
Cdd:pfam00271  94 NPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
33-104 4.63e-13

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 64.93  E-value: 4.63e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907068317   33 RYIRIDGSVPSSERIHLVNQFQKDPdtRVAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIG 104
Cdd:smart00490  13 KVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 2-111 6.23e-08

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 56.35  E-value: 6.23e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068317    2 LLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTR-VAILSIQAAGQGLTFTAASH 80
Cdd:PLN03142   483 LKERDS-RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADI 561

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1907068317   81 VVFAELYWDPGHIKQAEDRAHRIGQCSSVNI 111
Cdd:PLN03142   562 VILYDSDWNPQVDLQAQDRAHRIGQKKEVQV 592
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 690-755 1.30e-07

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 49.01  E-value: 1.30e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907068317 690 KSHRKSLLNAAWTAKLPLEqlnemlrnPGEGHFWQVDHIRPVyEGGGQCSLDNLQTLCTVCHKERT 755
Cdd:cd00085     1 RSHRLVLLARDGLCPYCGK--------PGGTEGLEVDHIIPL-SDGGNNDLDNLVLLCRKCHRKKH 57
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
659-752 1.31e-05

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 43.43  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068317 659 LRAQVFATEHGVCQHCGvdaqelflrmrdapkshrksllnaawtaklpleqlnemlrNPGEGHFWQVDHIRPVYEGGGQc 738
Cdd:COG1403    10 LRRAVLKRDNGRCQYCG----------------------------------------RPFSGDALEVDHIIPRSRGGTD- 48

                          90
                  ....*....|....
gi 1907068317 739 SLDNLQTLCTVCHK 752
Cdd:COG1403    49 TWENLVLLCRRCNR 62
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 722-757 2.21e-05

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 42.34  E-value: 2.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907068317 722 FWQVDHIRPVYEGGGQcSLDNLQTLCTVCHKERTAQ 757
Cdd:pfam01844  13 ALTVDHIIPLSDGGAD-DIENLILLCPSCHNKKHNR 47
HNHc smart00507
HNH nucleases;
723-751 3.72e-04

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 38.98  E-value: 3.72e-04
                           10        20
                   ....*....|....*....|....*....
gi 1907068317  723 WQVDHIRPvYEGGGQCSLDNLQTLCTVCH 751
Cdd:smart00507  24 LEVDHIIP-LSDGGNDDLDNLVLLCPKCH 51
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 290-312 2.26e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 36.14  E-value: 2.26e-03
                           10        20
                   ....*....|....*....|...
gi 1907068317  290 WQCGFCTFLNNPGLPYCEMCENP 312
Cdd:smart00547   3 WECPACTFLNFASRSKCFACGAP 25
guided_IscB NF040563
RNA-guided endonuclease IscB;
724-761 8.40e-03

RNA-guided endonuclease IscB;


Pssm-ID: 468538 [Multi-domain]  Cd Length: 315  Bit Score: 39.07  E-value: 8.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907068317 724 QVDHIRPVYEGGGQcSLDNLQTLCTVCHKERTAQQAKE 761
Cdd:NF040563  207 EVHHIVPRSKGGSD-RVSNLILACEPCNQKKGNQPVEE 243
 
Name Accession Description Interval E-value
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 9-115 2.41e-42

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 150.32  E-value: 2.41e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068317   9 KFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAAGQGLTFTAASHVVFAELYW 88
Cdd:cd18793    29 KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAGGVGLNLTAANRVILYDPWW 108

                          90       100
                  ....*....|....*....|....*..
gi 1907068317  89 DPGHIKQAEDRAHRIGQCSSVNIHYLI 115
Cdd:cd18793   109 NPAVEEQAIDRAHRIGQKKPVVVYRLI 135
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 9-133 4.14e-34

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 139.59  E-value: 4.14e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068317   9 KFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAAGQGLTFTAASHVVFAELYW 88
Cdd:COG0553   551 KVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWW 630

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1907068317  89 DPGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDSLMWAMLNRKAQ 133
Cdd:COG0553   631 NPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA 675
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 9-104 1.95e-14

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 69.93  E-value: 1.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068317   9 KFLVFAHHLSMLQaCTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVaILSIQAAGQGLTFTAASHVVFAELYW 88
Cdd:pfam00271  17 KVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDV-LVATDVAERGLDLPDVDLVINYDLPW 93

                          90
                  ....*....|....*.
gi 1907068317  89 DPGHIKQAEDRAHRIG 104
Cdd:pfam00271  94 NPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
33-104 4.63e-13

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 64.93  E-value: 4.63e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907068317   33 RYIRIDGSVPSSERIHLVNQFQKDPdtRVAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIG 104
Cdd:smart00490  13 KVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 2-111 6.23e-08

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 56.35  E-value: 6.23e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068317    2 LLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTR-VAILSIQAAGQGLTFTAASH 80
Cdd:PLN03142   483 LKERDS-RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADI 561

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1907068317   81 VVFAELYWDPGHIKQAEDRAHRIGQCSSVNI 111
Cdd:PLN03142   562 VILYDSDWNPQVDLQAQDRAHRIGQKKEVQV 592
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 690-755 1.30e-07

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 49.01  E-value: 1.30e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907068317 690 KSHRKSLLNAAWTAKLPLEqlnemlrnPGEGHFWQVDHIRPVyEGGGQCSLDNLQTLCTVCHKERT 755
Cdd:cd00085     1 RSHRLVLLARDGLCPYCGK--------PGGTEGLEVDHIIPL-SDGGNNDLDNLVLLCRKCHRKKH 57
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
659-752 1.31e-05

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 43.43  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068317 659 LRAQVFATEHGVCQHCGvdaqelflrmrdapkshrksllnaawtaklpleqlnemlrNPGEGHFWQVDHIRPVYEGGGQc 738
Cdd:COG1403    10 LRRAVLKRDNGRCQYCG----------------------------------------RPFSGDALEVDHIIPRSRGGTD- 48

                          90
                  ....*....|....
gi 1907068317 739 SLDNLQTLCTVCHK 752
Cdd:COG1403    49 TWENLVLLCRRCNR 62
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 722-757 2.21e-05

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 42.34  E-value: 2.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907068317 722 FWQVDHIRPVYEGGGQcSLDNLQTLCTVCHKERTAQ 757
Cdd:pfam01844  13 ALTVDHIIPLSDGGAD-DIENLILLCPSCHNKKHNR 47
HNHc smart00507
HNH nucleases;
723-751 3.72e-04

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 38.98  E-value: 3.72e-04
                           10        20
                   ....*....|....*....|....*....
gi 1907068317  723 WQVDHIRPvYEGGGQCSLDNLQTLCTVCH 751
Cdd:smart00507  24 LEVDHIIP-LSDGGNDDLDNLVLLCPKCH 51
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 290-312 2.26e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 36.14  E-value: 2.26e-03
                           10        20
                   ....*....|....*....|...
gi 1907068317  290 WQCGFCTFLNNPGLPYCEMCENP 312
Cdd:smart00547   3 WECPACTFLNFASRSKCFACGAP 25
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 62-115 7.69e-03

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 36.14  E-value: 7.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907068317  62 AILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVnIHYLI 115
Cdd:cd18785    25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGE-VILFV 77
guided_IscB NF040563
RNA-guided endonuclease IscB;
724-761 8.40e-03

RNA-guided endonuclease IscB;


Pssm-ID: 468538 [Multi-domain]  Cd Length: 315  Bit Score: 39.07  E-value: 8.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907068317 724 QVDHIRPVYEGGGQcSLDNLQTLCTVCHKERTAQQAKE 761
Cdd:NF040563  207 EVHHIVPRSKGGSD-RVSNLILACEPCNQKKGNQPVEE 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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