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Conserved domains on  [gi|1907154465|ref|XP_036019644|]
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leptin receptor isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 430-532 3.34e-42

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


:

Pssm-ID: 465812  Cd Length: 105  Bit Score: 149.03  E-value: 3.34e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 430 NINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHP--TSEPKNCVLQRDGFYECVFQPIFLLSG 507
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLADSKVNLRYRRSELSCEDRSTSSLkgGSMVKECDCQGPGFYECTIQPLYLNST 80

                          90       100
                  ....*....|....*....|....*
gi 1907154465 508 YTMWIRINHSLGSLDSPPTCVLPDS 532
Cdd:pfam18589  81 YIMWLEISHGLGPLQSPPMSVKPID 105
ObR_Ig super family cl39908
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 127-232 1.31e-21

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


The actual alignment was detected with superfamily member pfam18589:

Pssm-ID: 465812  Cd Length: 105  Bit Score: 90.48  E-value: 1.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 127 NWDIECWMKGDLTLFICHMEPLPKNPFKnyDSKVHLLYDLPEV-IDDSPLPPLKDSFQTVQCNCSL-RGCECHVPVPRak 204
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLA--DSKVNLRYRRSELsCEDRSTSSLKGGSMVKECDCQGpGFYECTIQPLY-- 76

                          90       100
                  ....*....|....*....|....*...
gi 1907154465 205 LNYALLMYLEITSAGVSFQSPLMSLQPM 232
Cdd:pfam18589  77 LNSTYIMWLEISHGLGPLQSPPMSVKPI 104
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 328-419 1.37e-18

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 81.13  E-value: 1.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 328 TTQDVVYFPPKIlTSVGSNASFHCIYKN---ENQIISSKQIVWWRNLaEKIPEIQYSIVSDRVSKVTFSNLKATRPrgkf 404
Cdd:pfam06328   1 EPCGHISPSPPV-VRLGSNVTASCILKEnccSHLGVEAQIIVWKLGL-ELIPGSQYTVLNDTVSSVTLPNLNSTRA---- 74

                          90
                  ....*....|....*.
gi 1907154465 405 tydAVYCCNE-QACHH 419
Cdd:pfam06328  75 ---LLTCCLLwGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-329 2.36e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 2.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 237 PDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQ-YQVKYLE--NSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 313
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgYVVEYREkgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|....*.
gi 1907154465 314 GsgvWSDWSSPQVFTT 329
Cdd:cd00063    81 G---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 738-819 1.50e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 1.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465  738 SAVESLSAYPLSSSCVILSWTLSPDDYSLLYlVIEWKILNEDDGMKWLRIPSNVKK-FYIHDNFIPIEKYQFSLYPVFME 816
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGY-IVGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 1907154465  817 GVG 819
Cdd:smart00060  81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 536-626 6.90e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.48  E-value: 6.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 536 PLPPSNVKAEITVNTGLLkVSWEKPVFPENNLQ-FQIRYGLSGKEiQWKTHEVFDAKSKSASL--LVSDlcAVYVVQVRC 612
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVT-LSWTPPEDDGGPITgYVVEYREKGSG-DWKEVEVTPGSETSYTLtgLKPG--TEYEFRVRA 76

                          90
                  ....*....|....
gi 1907154465 613 RRLDGLGYWSNWSS 626
Cdd:cd00063    77 VNGGGESPPSESVT 90
 
Name Accession Description Interval E-value
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 430-532 3.34e-42

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 149.03  E-value: 3.34e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 430 NINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHP--TSEPKNCVLQRDGFYECVFQPIFLLSG 507
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLADSKVNLRYRRSELSCEDRSTSSLkgGSMVKECDCQGPGFYECTIQPLYLNST 80

                          90       100
                  ....*....|....*....|....*
gi 1907154465 508 YTMWIRINHSLGSLDSPPTCVLPDS 532
Cdd:pfam18589  81 YIMWLEISHGLGPLQSPPMSVKPID 105
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 127-232 1.31e-21

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 90.48  E-value: 1.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 127 NWDIECWMKGDLTLFICHMEPLPKNPFKnyDSKVHLLYDLPEV-IDDSPLPPLKDSFQTVQCNCSL-RGCECHVPVPRak 204
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLA--DSKVNLRYRRSELsCEDRSTSSLKGGSMVKECDCQGpGFYECTIQPLY-- 76

                          90       100
                  ....*....|....*....|....*...
gi 1907154465 205 LNYALLMYLEITSAGVSFQSPLMSLQPM 232
Cdd:pfam18589  77 LNSTYIMWLEISHGLGPLQSPPMSVKPI 104
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 328-419 1.37e-18

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 81.13  E-value: 1.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 328 TTQDVVYFPPKIlTSVGSNASFHCIYKN---ENQIISSKQIVWWRNLaEKIPEIQYSIVSDRVSKVTFSNLKATRPrgkf 404
Cdd:pfam06328   1 EPCGHISPSPPV-VRLGSNVTASCILKEnccSHLGVEAQIIVWKLGL-ELIPGSQYTVLNDTVSSVTLPNLNSTRA---- 74

                          90
                  ....*....|....*.
gi 1907154465 405 tydAVYCCNE-QACHH 419
Cdd:pfam06328  75 ---LLTCCLLwGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-329 2.36e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 2.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 237 PDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQ-YQVKYLE--NSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 313
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgYVVEYREkgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|....*.
gi 1907154465 314 GsgvWSDWSSPQVFTT 329
Cdd:cd00063    81 G---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 237-316 3.48e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 3.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465  237 PDPPLGLHMEVTDDGNLKISWDSQTMAP---FPLQYQVKYLENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 313
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 1907154465  314 GSG 316
Cdd:smart00060  81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 738-819 1.50e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 1.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465  738 SAVESLSAYPLSSSCVILSWTLSPDDYSLLYlVIEWKILNEDDGMKWLRIPSNVKK-FYIHDNFIPIEKYQFSLYPVFME 816
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGY-IVGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 1907154465  817 GVG 819
Cdd:smart00060  81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
234-410 2.13e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 234 VVKPDPPLGLHMEVTDDGNLKISWDSQTmAPFPLQYQVKY-LENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKrl 312
Cdd:COG3401   324 LTPPAAPSGLTATAVGSSSITLSWTASS-DADVTGYNVYRsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV-- 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 313 DGSGVWSDWSSPqVFTTQDVVYFPPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVS-DRVSKVT 391
Cdd:COG3401   401 DAAGNESAPSEE-VSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTtTSSTVTA 479

                         170
                  ....*....|....*....
gi 1907154465 392 FSNLKATRPRGKFTYDAVY 410
Cdd:COG3401   480 TTTDTTTANLSVTTGSLVG 498
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 738-821 5.79e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.48  E-value: 5.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 738 SAVESLSAYPLSSSCVILSWTLSPDDYSLL--YlVIEWKILNEDDGMKWLRIPSNVKKFYIhDNFIPIEKYQFSLYPVFM 815
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPItgY-VVEYREKGSGDWKEVEVTPGSETSYTL-TGLKPGTEYEFRVRAVNG 79


                  ....*.
gi 1907154465 816 EGVGKP 821
Cdd:cd00063    80 GGESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 536-626 6.90e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.48  E-value: 6.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 536 PLPPSNVKAEITVNTGLLkVSWEKPVFPENNLQ-FQIRYGLSGKEiQWKTHEVFDAKSKSASL--LVSDlcAVYVVQVRC 612
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVT-LSWTPPEDDGGPITgYVVEYREKGSG-DWKEVEVTPGSETSYTLtgLKPG--TEYEFRVRA 76

                          90
                  ....*....|....
gi 1907154465 613 RRLDGLGYWSNWSS 626
Cdd:cd00063    77 VNGGGESPPSESVT 90
fn3 pfam00041
Fibronectin type III domain;
238-319 8.86e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 8.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 238 DPPLGLHMEVTDDGNLKISWDsqtmAPFPLQ-----YQVKYLENSTIVREAAEIVS--ATSLLVDSVLPGSSYEVQVRSK 310
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWT----PPPDGNgpitgYEVEYRPKNSGEPWNEITVPgtTTSVTLTGLKPGTEYEVRVQAV 76


                  ....*....
gi 1907154465 311 RLDGSGVWS 319
Cdd:pfam00041  77 NGGGEGPPS 85
 
Name Accession Description Interval E-value
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 430-532 3.34e-42

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 149.03  E-value: 3.34e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 430 NINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHP--TSEPKNCVLQRDGFYECVFQPIFLLSG 507
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLADSKVNLRYRRSELSCEDRSTSSLkgGSMVKECDCQGPGFYECTIQPLYLNST 80

                          90       100
                  ....*....|....*....|....*
gi 1907154465 508 YTMWIRINHSLGSLDSPPTCVLPDS 532
Cdd:pfam18589  81 YIMWLEISHGLGPLQSPPMSVKPID 105
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 127-232 1.31e-21

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 90.48  E-value: 1.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 127 NWDIECWMKGDLTLFICHMEPLPKNPFKnyDSKVHLLYDLPEV-IDDSPLPPLKDSFQTVQCNCSL-RGCECHVPVPRak 204
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLA--DSKVNLRYRRSELsCEDRSTSSLKGGSMVKECDCQGpGFYECTIQPLY-- 76

                          90       100
                  ....*....|....*....|....*...
gi 1907154465 205 LNYALLMYLEITSAGVSFQSPLMSLQPM 232
Cdd:pfam18589  77 LNSTYIMWLEISHGLGPLQSPPMSVKPI 104
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 328-419 1.37e-18

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 81.13  E-value: 1.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 328 TTQDVVYFPPKIlTSVGSNASFHCIYKN---ENQIISSKQIVWWRNLaEKIPEIQYSIVSDRVSKVTFSNLKATRPrgkf 404
Cdd:pfam06328   1 EPCGHISPSPPV-VRLGSNVTASCILKEnccSHLGVEAQIIVWKLGL-ELIPGSQYTVLNDTVSSVTLPNLNSTRA---- 74

                          90
                  ....*....|....*.
gi 1907154465 405 tydAVYCCNE-QACHH 419
Cdd:pfam06328  75 ---LLTCCLLwGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-329 2.36e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 2.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 237 PDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQ-YQVKYLE--NSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 313
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgYVVEYREkgSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|....*.
gi 1907154465 314 GsgvWSDWSSPQVFTT 329
Cdd:cd00063    81 G---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 237-316 3.48e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 3.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465  237 PDPPLGLHMEVTDDGNLKISWDSQTMAP---FPLQYQVKYLENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLD 313
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 1907154465  314 GSG 316
Cdd:smart00060  81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 738-819 1.50e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 1.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465  738 SAVESLSAYPLSSSCVILSWTLSPDDYSLLYlVIEWKILNEDDGMKWLRIPSNVKK-FYIHDNFIPIEKYQFSLYPVFME 816
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGY-IVGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 1907154465  817 GVG 819
Cdd:smart00060  81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
234-410 2.13e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 234 VVKPDPPLGLHMEVTDDGNLKISWDSQTmAPFPLQYQVKY-LENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKrl 312
Cdd:COG3401   324 LTPPAAPSGLTATAVGSSSITLSWTASS-DADVTGYNVYRsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV-- 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 313 DGSGVWSDWSSPqVFTTQDVVYFPPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVS-DRVSKVT 391
Cdd:COG3401   401 DAAGNESAPSEE-VSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTtTSSTVTA 479

                         170
                  ....*....|....*....
gi 1907154465 392 FSNLKATRPRGKFTYDAVY 410
Cdd:COG3401   480 TTTDTTTANLSVTTGSLVG 498
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 738-821 5.79e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.48  E-value: 5.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 738 SAVESLSAYPLSSSCVILSWTLSPDDYSLL--YlVIEWKILNEDDGMKWLRIPSNVKKFYIhDNFIPIEKYQFSLYPVFM 815
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPItgY-VVEYREKGSGDWKEVEVTPGSETSYTL-TGLKPGTEYEFRVRAVNG 79


                  ....*.
gi 1907154465 816 EGVGKP 821
Cdd:cd00063    80 GGESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 536-626 6.90e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.48  E-value: 6.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 536 PLPPSNVKAEITVNTGLLkVSWEKPVFPENNLQ-FQIRYGLSGKEiQWKTHEVFDAKSKSASL--LVSDlcAVYVVQVRC 612
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVT-LSWTPPEDDGGPITgYVVEYREKGSG-DWKEVEVTPGSETSYTLtgLKPG--TEYEFRVRA 76

                          90
                  ....*....|....
gi 1907154465 613 RRLDGLGYWSNWSS 626
Cdd:cd00063    77 VNGGGESPPSESVT 90
fn3 pfam00041
Fibronectin type III domain;
238-319 8.86e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 8.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154465 238 DPPLGLHMEVTDDGNLKISWDsqtmAPFPLQ-----YQVKYLENSTIVREAAEIVS--ATSLLVDSVLPGSSYEVQVRSK 310
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWT----PPPDGNgpitgYEVEYRPKNSGEPWNEITVPgtTTSVTLTGLKPGTEYEVRVQAV 76


                  ....*....
gi 1907154465 311 RLDGSGVWS 319
Cdd:pfam00041  77 NGGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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