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Conserved domains on  [gi|1907151879|ref|XP_036019131|]
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tetratricopeptide repeat protein 14 isoform X3 [Mus musculus]

Protein Classification

M48 family metallopeptidase( domain architecture ID 11469162)

M48 family metallopeptidase such as beta-barrel assembly-enhancing protease, which functions as both a chaperone and a metalloprotease, maintaining the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 97-222 3.45e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 66.75  E-value: 3.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  97 KIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGgq 176
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAG-- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907151879 177 leeeeKFLNAESYYKKALTLDETFKDAEDALQKLHKYMQKSLELRE 222
Cdd:COG4783    87 -----DYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIA 127
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 97-222 3.45e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 66.75  E-value: 3.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  97 KIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGgq 176
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAG-- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907151879 177 leeeeKFLNAESYYKKALTLDETFKDAEDALQKLHKYMQKSLELRE 222
Cdd:COG4783    87 -----DYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIA 127
TPR_11 pfam13414
TPR repeat;
102-140 6.26e-05

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 40.53  E-value: 6.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907151879 102 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKG 140
Cdd:pfam13414   4 YYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 115-196 9.08e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.54  E-value: 9.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 115 YNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHrNARKYLCqtLvergGQLEEEEkflNAESYYKKAL 194
Cdd:cd24142    23 LQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDG-GYEKYLY--L----GQLSGGE---EALQYYEKGI 92


                  ..
gi 1907151879 195 TL 196
Cdd:cd24142    93 EI 94
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 68-216 7.29e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 7.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  68 GLQSKNFSEDDFASALRKKQSASWAlkcvKIGVDYFKV--GRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKA 145
Cdd:TIGR02917 137 GLGQLELAQKSYEQALAIDPRSLYA----KLGLAQLALaeNRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELA 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 146 IEDFELALENCPTHRNARKYLCQTLVERgGQLEEEEKFLNA---------ESYYKKALtLDETFKDAEDALQKLHKYMQK 216
Cdd:TIGR02917 213 LAAYRKAIALRPNNIAVLLALATILIEA-GEFEEAEKHADAllkkapnspLAHYLKAL-VDFQKKNYEDARETLQDALKS 290
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 97-222 3.45e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 66.75  E-value: 3.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  97 KIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGgq 176
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAG-- 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907151879 177 leeeeKFLNAESYYKKALTLDETFKDAEDALQKLHKYMQKSLELRE 222
Cdd:COG4783    87 -----DYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIA 127
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
17-225 7.94e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.49  E-value: 7.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  17 YYRRSVELNSNSLESYENimqssLGFVnpgvveflLEKLG-IDEShppslmrglqsknfsEDDFASALRKKQSASWALkc 95
Cdd:COG0457    30 DYEKALELDPDDAEALYN-----LGLA--------YLRLGrYEEA---------------LADYEQALELDPDDAEAL-- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  96 VKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgG 175
Cdd:COG0457    80 NNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL-G 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907151879 176 QLEEEEKFLNAESYYKKALTLDETFKDAEDALQKLHKYMQKSLELREKQA 225
Cdd:COG0457   159 RYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALR 208
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
98-223 1.11e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 1.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  98 IGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQL 177
Cdd:COG0457    14 LGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQAL-GRY 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907151879 178 EEeekflnAESYYKKALTLDETFKDAED----ALQKLHKYmQKSLELREK 223
Cdd:COG0457    93 EE------ALEDYDKALELDPDDAEALYnlglALLELGRY-DEAIEAYER 135
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 102-207 9.39e-12

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 62.33  E-value: 9.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 102 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLcqtlverGGQLEEEE 181
Cdd:COG4235    27 YLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLL-------GLAAFQQG 99

                          90       100
                  ....*....|....*....|....*.
gi 1907151879 182 KFLNAESYYKKALTLDEtfKDAEDAL 207
Cdd:COG4235   100 DYAEAIAAWQKLLALLP--ADAPARL 123
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 102-197 2.73e-11

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 61.90  E-value: 2.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 102 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGgqleeee 181
Cdd:COG5010    64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLG------- 136

                          90
                  ....*....|....*.
gi 1907151879 182 KFLNAESYYKKALTLD 197
Cdd:COG5010   137 QDDEAKAALQRALGTS 152
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 79-211 2.77e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.37  E-value: 2.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  79 FASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPT 158
Cdd:COG2956    65 HQKLLERDPDRAEAL--LELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907151879 159 HRNArkylcqtLVERGGQLEEEEKFLNAESYYKKALTLDETFKDAEDALQKLH 211
Cdd:COG2956   143 NAHA-------YCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELY 188
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 98-203 3.02e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.17  E-value: 3.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  98 IGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLvERGGQL 177
Cdd:COG3914   118 LGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNAL-QDLGRL 196

                          90       100
                  ....*....|....*....|....*.
gi 1907151879 178 EEeekflnAESYYKKALTLDETFKDA 203
Cdd:COG3914   197 EE------AIAAYRRALELDPDNADA 216
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
102-197 2.91e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 57.10  E-value: 2.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 102 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEdFELALENCPTHRNARKYLCQTLVERGgqleeee 181
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELG------- 73

                          90
                  ....*....|....*.
gi 1907151879 182 KFLNAESYYKKALTLD 197
Cdd:COG3063    74 DYDEALAYLERALELD 89
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 76-197 3.32e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 58.28  E-value: 3.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  76 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 155
Cdd:COG4783    24 EALLEKALELDPDNPEAF--ALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKL 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1907151879 156 CPTHRNARKYLCQTLVERGgqleeeeKFLNAESYYKKALTLD 197
Cdd:COG4783   102 DPEHPEAYLRLARAYRALG-------RPDEAIAALEKALELD 136
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 99-210 4.60e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.51  E-value: 4.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  99 GVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLE 178
Cdd:COG2956    15 GLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKA-GLLD 93

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907151879 179 EeekflnAESYYKKALTLDEtfkDAEDALQKL 210
Cdd:COG2956    94 R------AEELLEKLLELDP---DDAEALRLL 116
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 106-225 1.99e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.39  E-value: 1.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 106 GRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLEEeekfln 185
Cdd:COG3914    92 GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRL-GRLEE------ 164

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907151879 186 AESYYKKALTLDETFKDAE----DALQKLHKY------MQKSLELREKQA 225
Cdd:COG3914   165 AIAALRRALELDPDNAEALnnlgNALQDLGRLeeaiaaYRRALELDPDNA 214
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
77-221 1.14e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 55.69  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  77 DDFASALRKKQSASWALKCVKI----GVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELA 152
Cdd:COG4785    54 AAAALAAERIDRALALPDLAQLyyerGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRA 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 153 LENCPTHRNARKYLCQTLvERGGQLEEeekflnAESYYKKALTLD-------------ETFKDAEDALQKLHKYMQKSLE 219
Cdd:COG4785   134 LELDPDYAYAYLNRGIAL-YYLGRYEL------AIADLEKALELDpndperalwlylaERKLDPEKALALLLEDWATAYL 206


                  ..
gi 1907151879 220 LR 221
Cdd:COG4785   207 LQ 208
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 16-212 3.29e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.54  E-value: 3.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  16 LYYRRSVELNSNSLESYENImqsslgfvnpGVVEFLLEKLgiDEShppslmrglqsknfsEDDFASALRKKqsASWALKC 95
Cdd:COG3914    99 ALYRRALALNPDNAEALFNL----------GNLLLALGRL--EEA---------------LAALRRALALN--PDFAEAY 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  96 VKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGG 175
Cdd:COG3914   150 LNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACD 229

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907151879 176 qLEEEEKFLNAESYYKKALTLDETF------KDAEDALQKLHK 212
Cdd:COG3914   230 -WEVYDRFEELLAALARGPSELSPFallylpDDDPAELLALAR 271
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
119-225 3.48e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.55  E-value: 3.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 119 LEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKALTLDE 198
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRL-GRYEE------ALADYEQALELDP 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1907151879 199 TFKDA----EDALQKLHKY------MQKSLELREKQA 225
Cdd:COG0457    74 DDAEAlnnlGLALQALGRYeealedYDKALELDPDDA 110
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
76-157 1.05e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 44.01  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  76 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMnEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 155
Cdd:COG3063    12 EEYYEKALELDPDNADAL--NNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALEL 88


                  ..
gi 1907151879 156 CP 157
Cdd:COG3063    89 DP 90
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 110-203 1.58e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 44.61  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 110 DAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGGQLEeeekflnAESY 189
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEE-------AEEL 73

                          90
                  ....*....|....
gi 1907151879 190 YKKALTLDETFKDA 203
Cdd:COG4235    74 LERALALDPDNPEA 87
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 76-159 3.55e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.64  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  76 EDDFASALRKKQSASWALkcVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALEN 155
Cdd:COG4783    58 IVLLHEALELDPDEPEAR--LNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135


                  ....
gi 1907151879 156 CPTH 159
Cdd:COG4783   136 DPDD 139
TPR_11 pfam13414
TPR repeat;
102-140 6.26e-05

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 40.53  E-value: 6.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907151879 102 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKG 140
Cdd:pfam13414   4 YYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 115-196 9.08e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.54  E-value: 9.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 115 YNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHrNARKYLCqtLvergGQLEEEEkflNAESYYKKAL 194
Cdd:cd24142    23 LQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDG-GYEKYLY--L----GQLSGGE---EALQYYEKGI 92


                  ..
gi 1907151879 195 TL 196
Cdd:cd24142    93 EI 94
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 98-157 1.22e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 1.22e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  98 IGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCP 157
Cdd:COG5010    94 LALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 114-222 2.29e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.87  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 114 EYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKA 193
Cdd:COG5010    42 LAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRS-GDKDE------AKEYYEKA 114

                          90       100
                  ....*....|....*....|....*....
gi 1907151879 194 LTLDETFKDAEDALQKLHKYMQKSLELRE 222
Cdd:COG5010   115 LALSPDNPNAYSNLAALLLSLGQDDEAKA 143
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 124-220 5.59e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.18  E-value: 5.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 124 QNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERgGQLEEeekflnAESYYKKALTLDETFKDA 203
Cdd:COG4783     2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQL-GDLDE------AIVLLHEALELDPDEPEA 74

                          90       100
                  ....*....|....*....|....*..
gi 1907151879 204 E----DALQKLHKY------MQKSLEL 220
Cdd:COG4783    75 RlnlgLALLKAGDYdealalLEKALKL 101
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 68-216 7.29e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 7.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  68 GLQSKNFSEDDFASALRKKQSASWAlkcvKIGVDYFKV--GRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKA 145
Cdd:TIGR02917 137 GLGQLELAQKSYEQALAIDPRSLYA----KLGLAQLALaeNRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELA 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 146 IEDFELALENCPTHRNARKYLCQTLVERgGQLEEEEKFLNA---------ESYYKKALtLDETFKDAEDALQKLHKYMQK 216
Cdd:TIGR02917 213 LAAYRKAIALRPNNIAVLLALATILIEA-GEFEEAEKHADAllkkapnspLAHYLKAL-VDFQKKNYEDARETLQDALKS 290
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 102-187 3.26e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 3.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879 102 YFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLcqTLVERGGQLEEEE 181
Cdd:COG2956   188 YLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALA--DLLERKEGLEAAL 265


                  ....*.
gi 1907151879 182 KFLNAE 187
Cdd:COG2956   266 ALLERQ 271
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 97-159 5.16e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 35.77  E-value: 5.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907151879  97 KIGVDYFKVGRHVDAMNEYNKALEIDK---QNVEALVARGALYATKGSLNKAIEDFELALENCPTH 159
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALARFPespDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 80-217 6.42e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 6.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151879  80 ASALRKKQSASWALKcvkiGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTH 159
Cdd:TIGR02917 593 AADAAPDSPEAWLML----GRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDN 668

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907151879 160 RNARKYLCQTLVErGGQLEEEEKFL------NAESYYKKALTLDETF--KDAEDALQKLHKYMQKS 217
Cdd:TIGR02917 669 TEAQIGLAQLLLA-AKRTESAKKIAkslqkqHPKAALGFELEGDLYLrqKDYPAAIQAYRKALKRA 733
TPR_1 pfam00515
Tetratricopeptide repeat;
126-159 7.13e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 34.32  E-value: 7.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907151879 126 VEALVARGALYATKGSLNKAIEDFELALENCPTH 159
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 122-196 9.04e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 9.04e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907151879 122 DKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGgqleeeeKFLNAESYYKKALTL 196
Cdd:TIGR02917  18 GDQSPEELIEAAKSYLQKNKYKAAIIQLKNALQKDPNDAEARFLLGKIYLALG-------DYAAAEKELRKALSL 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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