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Conserved domains on  [gi|1907150233|ref|XP_036018947|]
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DENN domain-containing protein 4B isoform X4 [Mus musculus]

Protein Classification

dDENN domain-containing protein( domain architecture ID 13925273)

dDENN domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 1-63 1.11e-16

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 75.02  E-value: 1.11e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907150233    1 MACLLKGYRNFLRPLtqapsEGSRDVDNLFYLQGFLKSRERSSHKLYSQLLHTQMFSQFIEEC 63
Cdd:smart00801  12 FVNLFGGYRNFLREL-----RKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
PPR_2 super family cl38385
PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is ...
 238-278 7.53e-05

PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins. The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR.


The actual alignment was detected with superfamily member pfam13041:

Pssm-ID: 463778 [Multi-domain]  Cd Length: 50  Bit Score: 40.81  E-value: 7.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907150233 238 PDEVCYRVLMQLCSHYGQPVLSVRVMLEMRRAGIVPNTITY 278
Cdd:pfam13041   1 PDVVTYNTLINGYCKKGKVEEAFKLFNEMKKRGVKPNVYTY 41
 
Name Accession Description Interval E-value
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 1-63 1.11e-16

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 75.02  E-value: 1.11e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907150233    1 MACLLKGYRNFLRPLtqapsEGSRDVDNLFYLQGFLKSRERSSHKLYSQLLHTQMFSQFIEEC 63
Cdd:smart00801  12 FVNLFGGYRNFLREL-----RKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 30-79 2.35e-13

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 64.91  E-value: 2.35e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907150233  30 FYLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSarHAALEFFDSC 79
Cdd:pfam03455   1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS--DPSIDLFDEE 48
PPR_2 pfam13041
PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is ...
 238-278 7.53e-05

PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins. The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR.


Pssm-ID: 463778 [Multi-domain]  Cd Length: 50  Bit Score: 40.81  E-value: 7.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907150233 238 PDEVCYRVLMQLCSHYGQPVLSVRVMLEMRRAGIVPNTITY 278
Cdd:pfam13041   1 PDVVTYNTLINGYCKKGKVEEAFKLFNEMKKRGVKPNVYTY 41
PPR TIGR00756
pentatricopeptide repeat domain (PPR motif); This model describes a domain called the PPR ...
 241-275 9.11e-03

pentatricopeptide repeat domain (PPR motif); This model describes a domain called the PPR motif, or pentatricopeptide repeat. Its consensus sequence is 35 positions long and typically is found in four or more tandem copies. This family is strongly represented in plant proteins, particularly those sorted to chloroplasts or mitochondria. The pfam01535, domain of unknown function DUF17, consists of 6 copies of this repeat. This family has a similar consensus to the TPR domain (tetratricopeptide), pfam00515, a 33-residue repeat. It is predicted to form a pair of antiparallel helices similar to that of TPR.


Pssm-ID: 273253 [Multi-domain]  Cd Length: 35  Bit Score: 34.74  E-value: 9.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907150233 241 VCYRVLMQLCSHYGQPVLSVRVMLEMRRAGIVPNT 275
Cdd:TIGR00756   1 VTYNTLIDGLCKAGRVEEALELFKEMKERGIEPDV 35
 
Name Accession Description Interval E-value
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 1-63 1.11e-16

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 75.02  E-value: 1.11e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907150233    1 MACLLKGYRNFLRPLtqapsEGSRDVDNLFYLQGFLKSRERSSHKLYSQLLHTQMFSQFIEEC 63
Cdd:smart00801  12 FVNLFGGYRNFLREL-----RKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 30-79 2.35e-13

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 64.91  E-value: 2.35e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907150233  30 FYLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSarHAALEFFDSC 79
Cdd:pfam03455   1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS--DPSIDLFDEE 48
PPR_2 pfam13041
PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is ...
 238-278 7.53e-05

PPR repeat family; This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins. The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR.


Pssm-ID: 463778 [Multi-domain]  Cd Length: 50  Bit Score: 40.81  E-value: 7.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907150233 238 PDEVCYRVLMQLCSHYGQPVLSVRVMLEMRRAGIVPNTITY 278
Cdd:pfam13041   1 PDVVTYNTLINGYCKKGKVEEAFKLFNEMKKRGVKPNVYTY 41
PPR TIGR00756
pentatricopeptide repeat domain (PPR motif); This model describes a domain called the PPR ...
 241-275 9.11e-03

pentatricopeptide repeat domain (PPR motif); This model describes a domain called the PPR motif, or pentatricopeptide repeat. Its consensus sequence is 35 positions long and typically is found in four or more tandem copies. This family is strongly represented in plant proteins, particularly those sorted to chloroplasts or mitochondria. The pfam01535, domain of unknown function DUF17, consists of 6 copies of this repeat. This family has a similar consensus to the TPR domain (tetratricopeptide), pfam00515, a 33-residue repeat. It is predicted to form a pair of antiparallel helices similar to that of TPR.


Pssm-ID: 273253 [Multi-domain]  Cd Length: 35  Bit Score: 34.74  E-value: 9.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907150233 241 VCYRVLMQLCSHYGQPVLSVRVMLEMRRAGIVPNT 275
Cdd:TIGR00756   1 VTYNTLIDGLCKAGRVEEALELFKEMKERGIEPDV 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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