|
Name |
Accession |
Description |
Interval |
E-value |
| DENN |
smart00799 |
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ... |
63-241 |
7.53e-63 |
|
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
:
Pssm-ID: 214823 Cd Length: 183 Bit Score: 210.90 E-value: 7.53e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 63 SCFCILSYLPWFEVFYKLLNILADYTTKRQESQwNELLETLHRLPIPDPG-----VSVHLSVHSYFTVPDSRELPSIPen 137
Cdd:smart00799 3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 138 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 217
Cdd:smart00799 80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159
|
170 180
....*....|....*....|....
gi 1907138268 218 HLSLMEKVRNMALDDVVILNVDTN 241
Cdd:smart00799 160 HSSYFEEVKELPDEDVVVVDLDTG 183
|
|
| dDENN |
smart00801 |
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
273-339 |
1.86e-16 |
|
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
:
Pssm-ID: 129037 Cd Length: 69 Bit Score: 74.63 E-value: 1.86e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 273 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGR 339
Cdd:smart00801 1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
660-986 |
1.86e-14 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.44 E-value: 1.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 660 PSKPSITSPEKPSAllGTSPAlPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAG 739
Cdd:PHA03247 2616 PLPPDTHAPDPPPP--SPSPA-ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 740 GPLGDFSSEPLQ--MDRERQAALSPALLSGLLPRAVPQG---PTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 814
Cdd:PHA03247 2693 GSLTSLADPPPPppTPEPAPHALVSATPLPPGPAAARQAspaLPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 815 PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPfVPSVPVVPPSMPLSSTPARPFGTPPASL--GPAYAPSIL---LS 889
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAGPLPPPTSAQptAPPPPPGPPppsLP 2851
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 890 SSGFYAP----HRSQPNLSALSMPNLFGQIPMG-----AHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQglALRP 960
Cdd:PHA03247 2852 LGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP--PPQP 2929
|
330 340
....*....|....*....|....*.
gi 1907138268 961 GESPLLPPRPPQSLQPTPQPSVPTQA 986
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEP 2955
|
|
| uDENN super family |
cl04085 |
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ... |
26-59 |
7.48e-09 |
|
uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.
The actual alignment was detected with superfamily member smart00800:
Pssm-ID: 470944 Cd Length: 89 Bit Score: 53.88 E-value: 7.48e-09
10 20 30
....*....|....*....|....*....|....
gi 1907138268 26 TVTSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 59
Cdd:smart00800 56 DFVTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DENN |
smart00799 |
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ... |
63-241 |
7.53e-63 |
|
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 214823 Cd Length: 183 Bit Score: 210.90 E-value: 7.53e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 63 SCFCILSYLPWFEVFYKLLNILADYTTKRQESQwNELLETLHRLPIPDPG-----VSVHLSVHSYFTVPDSRELPSIPen 137
Cdd:smart00799 3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 138 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 217
Cdd:smart00799 80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159
|
170 180
....*....|....*....|....
gi 1907138268 218 HLSLMEKVRNMALDDVVILNVDTN 241
Cdd:smart00799 160 HSSYFEEVKELPDEDVVVVDLDTG 183
|
|
| DENN |
pfam02141 |
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ... |
64-241 |
6.32e-44 |
|
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.
Pssm-ID: 460461 Cd Length: 186 Bit Score: 157.35 E-value: 6.32e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 64 CFCILSYLPWFEVFYKLLNILAdytTKRQESQWNELLET-----LHRLPIPDPGVSVHLSVHS-----YFTVPDSRELPS 133
Cdd:pfam02141 5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 134 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 213
Cdd:pfam02141 82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159
|
170 180
....*....|....*....|....*...
gi 1907138268 214 LIGIHLSLMEKVRNmALDDVVILNVDTN 241
Cdd:pfam02141 160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
|
|
| dDENN |
smart00801 |
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
273-339 |
1.86e-16 |
|
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 129037 Cd Length: 69 Bit Score: 74.63 E-value: 1.86e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 273 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGR 339
Cdd:smart00801 1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
660-986 |
1.86e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.44 E-value: 1.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 660 PSKPSITSPEKPSAllGTSPAlPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAG 739
Cdd:PHA03247 2616 PLPPDTHAPDPPPP--SPSPA-ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 740 GPLGDFSSEPLQ--MDRERQAALSPALLSGLLPRAVPQG---PTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 814
Cdd:PHA03247 2693 GSLTSLADPPPPppTPEPAPHALVSATPLPPGPAAARQAspaLPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 815 PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPfVPSVPVVPPSMPLSSTPARPFGTPPASL--GPAYAPSIL---LS 889
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAGPLPPPTSAQptAPPPPPGPPppsLP 2851
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 890 SSGFYAP----HRSQPNLSALSMPNLFGQIPMG-----AHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQglALRP 960
Cdd:PHA03247 2852 LGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP--PPQP 2929
|
330 340
....*....|....*....|....*.
gi 1907138268 961 GESPLLPPRPPQSLQPTPQPSVPTQA 986
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEP 2955
|
|
| uDENN |
smart00800 |
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ... |
26-59 |
7.48e-09 |
|
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 214824 Cd Length: 89 Bit Score: 53.88 E-value: 7.48e-09
10 20 30
....*....|....*....|....*....|....
gi 1907138268 26 TVTSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 59
Cdd:smart00800 56 DFVTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
661-984 |
5.18e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 54.00 E-value: 5.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 661 SKPSITSPEK------PSALLGTSPALPLRPQNQEGILSPSikeETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAK 734
Cdd:pfam03154 144 TSPSIPSPQDnesdsdSSAQQQILQTQPPVLQAQSGAASPP---SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQ 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 735 LQAAGGPLGDFSSEPlQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPS------PAPGAAGTGsdallalldplnta 808
Cdd:pfam03154 221 TQSTAAPHTLIQQTP-TLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmpPMPHSLQTG-------------- 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 809 wsgstiPSHPATPSAATPF-IPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAY----- 882
Cdd:pfam03154 286 ------PSHMQHPVPPQPFpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHikppp 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 883 ---APSILLSSSGFYAPHRSQPnlSALSMP-------------NLFGQIPMGAHTSPL------QPLGPPAVAPSRIRTL 940
Cdd:pfam03154 360 ttpIPQLPNPQSHKHPPHLSGP--SPFQMNsnlppppalkplsSLSTHHPPSAHPPPLqlmpqsQQLPPPPAQPPVLTQS 437
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1907138268 941 PLARSSARAAEAKQGLALRPGESP-----LLPPRPPQSLQP-TPQPSVPT 984
Cdd:pfam03154 438 QSLPPPAASHPPTSGLHQVPSQSPfpqhpFVPGGPPPITPPsGPPTSTSS 487
|
|
| dDENN |
pfam03455 |
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ... |
305-356 |
7.19e-07 |
|
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.
Pssm-ID: 460925 Cd Length: 48 Bit Score: 46.80 E-value: 7.19e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1907138268 305 FSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 356
Cdd:pfam03455 1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
726-936 |
3.24e-05 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 47.58 E-value: 3.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 726 PPPTARPAKLQAAGGPLGDFSSEPLQMD---RERQAALSPALLSGLLPRAVPQGPTELLQPPSPApGAAGTGSDALLALL 802
Cdd:COG5651 165 TPFTQPPPTITNPGGLLGAQNAGSGNTSsnpGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNT-GFAGTGAAAGAAAA 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 803 DPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMP----LSSTPARPFGTPPASL 878
Cdd:COG5651 244 AAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAaatgLGLGAGGAAGAAGATG 323
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1907138268 879 GPAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSR 936
Cdd:COG5651 324 AGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGG 381
|
|
| uDENN |
pfam03456 |
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ... |
31-57 |
5.47e-03 |
|
uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.
Pssm-ID: 460926 Cd Length: 59 Bit Score: 36.05 E-value: 5.47e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DENN |
smart00799 |
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ... |
63-241 |
7.53e-63 |
|
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 214823 Cd Length: 183 Bit Score: 210.90 E-value: 7.53e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 63 SCFCILSYLPWFEVFYKLLNILADYTTKRQESQwNELLETLHRLPIPDPG-----VSVHLSVHSYFTVPDSRELPSIPen 137
Cdd:smart00799 3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 138 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 217
Cdd:smart00799 80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159
|
170 180
....*....|....*....|....
gi 1907138268 218 HLSLMEKVRNMALDDVVILNVDTN 241
Cdd:smart00799 160 HSSYFEEVKELPDEDVVVVDLDTG 183
|
|
| DENN |
pfam02141 |
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ... |
64-241 |
6.32e-44 |
|
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.
Pssm-ID: 460461 Cd Length: 186 Bit Score: 157.35 E-value: 6.32e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 64 CFCILSYLPWFEVFYKLLNILAdytTKRQESQWNELLET-----LHRLPIPDPGVSVHLSVHS-----YFTVPDSRELPS 133
Cdd:pfam02141 5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 134 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 213
Cdd:pfam02141 82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159
|
170 180
....*....|....*....|....*...
gi 1907138268 214 LIGIHLSLMEKVRNmALDDVVILNVDTN 241
Cdd:pfam02141 160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
|
|
| dDENN |
smart00801 |
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
273-339 |
1.86e-16 |
|
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 129037 Cd Length: 69 Bit Score: 74.63 E-value: 1.86e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 273 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGR 339
Cdd:smart00801 1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
660-986 |
1.86e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.44 E-value: 1.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 660 PSKPSITSPEKPSAllGTSPAlPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAG 739
Cdd:PHA03247 2616 PLPPDTHAPDPPPP--SPSPA-ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 740 GPLGDFSSEPLQ--MDRERQAALSPALLSGLLPRAVPQG---PTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 814
Cdd:PHA03247 2693 GSLTSLADPPPPppTPEPAPHALVSATPLPPGPAAARQAspaLPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 815 PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPfVPSVPVVPPSMPLSSTPARPFGTPPASL--GPAYAPSIL---LS 889
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAGPLPPPTSAQptAPPPPPGPPppsLP 2851
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 890 SSGFYAP----HRSQPNLSALSMPNLFGQIPMG-----AHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQglALRP 960
Cdd:PHA03247 2852 LGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP--PPQP 2929
|
330 340
....*....|....*....|....*.
gi 1907138268 961 GESPLLPPRPPQSLQPTPQPSVPTQA 986
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEP 2955
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
660-985 |
5.51e-13 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 73.82 E-value: 5.51e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 660 PSKPSITSPE-KPSAllgtsPALPLRPQnqegilspsikeeTPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAA 738
Cdd:PHA03247 2577 PSEPAVTSRArRPDA-----PPQSARPR-------------APVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 739 GGPLGDFSSEPLQMD------RERQAALSPALLSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAW-SG 811
Cdd:PHA03247 2639 DPHPPPTVPPPERPRddpapgRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALvSA 2718
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 812 STIPSHPATPSAATPFIPQLSFPPTVTPTPfvQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYAPSILLSSS 891
Cdd:PHA03247 2719 TPLPPGPAAARQASPALPAAPAPPAVPAGP--ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 892 GFYAPHRSQPNLSALSMPNlfgqIPMGAHTSPLQPLGPPavaPSRIRTLPLARSSARAAEAKQGLALRPG---------- 961
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPA----AALPPAASPAGPLPPP---TSAQPTAPPPPPGPPPPSLPLGGSVAPGgdvrrrppsr 2869
|
330 340
....*....|....*....|....*..
gi 1907138268 962 ---ESPLLPPRPPQSLQPTPQPSVPTQ 985
Cdd:PHA03247 2870 spaAKPAAPARPPVRRLARPAVSRSTE 2896
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
656-987 |
5.27e-11 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 67.27 E-value: 5.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 656 DMAIPSKPSITSPEKPSAllgTSPALPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPElgivPPPPTARPAKL 735
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHA---LVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA----RPPTTAGPPAP 2769
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 736 QAAGGPLGdfsSEPLQMDRERQAALSPALLSGLLPRAvPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTIP 815
Cdd:PHA03247 2770 APPAAPAA---GPPRRLTRPAVASLSESRESLPSPWD-PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 816 SHPATP--SAATPFIPQLSFPPTVTPTPFVQTPLNPfvpsvPVVPPSMPLSSTPARPFGTPPASLGPAYAPSIllsssgf 893
Cdd:PHA03247 2846 PPPSLPlgGSVAPGGDVRRRPPSRSPAAKPAAPARP-----PVRRLARPAVSRSTESFALPPDQPERPPQPQA------- 2913
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 894 YAPHRSQPNLSALSMPNLFGQIPmGAHTSPLQPLGPPAVAPSRIRTLPlarssaraaeAKQGLALRPGESPLLPPRPPQS 973
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPPP-PRPQPPLAPTTDPAGAGEPSGAVP----------QPWLGALVPGRVAVPRFRVPQP 2982
|
330
....*....|....
gi 1907138268 974 LQPTPQPSVPTQAR 987
Cdd:PHA03247 2983 APSREAPASSTPPL 2996
|
|
| uDENN |
smart00800 |
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ... |
26-59 |
7.48e-09 |
|
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 214824 Cd Length: 89 Bit Score: 53.88 E-value: 7.48e-09
10 20 30
....*....|....*....|....*....|....
gi 1907138268 26 TVTSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 59
Cdd:smart00800 56 DFVTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
661-984 |
5.18e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 54.00 E-value: 5.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 661 SKPSITSPEK------PSALLGTSPALPLRPQNQEGILSPSikeETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAK 734
Cdd:pfam03154 144 TSPSIPSPQDnesdsdSSAQQQILQTQPPVLQAQSGAASPP---SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQ 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 735 LQAAGGPLGDFSSEPlQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPS------PAPGAAGTGsdallalldplnta 808
Cdd:pfam03154 221 TQSTAAPHTLIQQTP-TLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmpPMPHSLQTG-------------- 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 809 wsgstiPSHPATPSAATPF-IPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAY----- 882
Cdd:pfam03154 286 ------PSHMQHPVPPQPFpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHikppp 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 883 ---APSILLSSSGFYAPHRSQPnlSALSMP-------------NLFGQIPMGAHTSPL------QPLGPPAVAPSRIRTL 940
Cdd:pfam03154 360 ttpIPQLPNPQSHKHPPHLSGP--SPFQMNsnlppppalkplsSLSTHHPPSAHPPPLqlmpqsQQLPPPPAQPPVLTQS 437
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1907138268 941 PLARSSARAAEAKQGLALRPGESP-----LLPPRPPQSLQP-TPQPSVPT 984
Cdd:pfam03154 438 QSLPPPAASHPPTSGLHQVPSQSPfpqhpFVPGGPPPITPPsGPPTSTSS 487
|
|
| dDENN |
pfam03455 |
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ... |
305-356 |
7.19e-07 |
|
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.
Pssm-ID: 460925 Cd Length: 48 Bit Score: 46.80 E-value: 7.19e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1907138268 305 FSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 356
Cdd:pfam03455 1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
659-982 |
2.76e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 51.69 E-value: 2.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 659 IPSKPSITSPEKPSALLGTSPALPLRPQNQEGILS-PSIKEETPIPTPGSITIPRPQGRKTPelgiVPPPPTARPAKLQA 737
Cdd:pfam03154 231 IQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPlPQPSLHGQMPPMPHSLQTGPSHMQHP----VPPQPFPLTPQSSQ 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 738 AGGPLGDFSSEPLQM-DRERQAALSPALLSGLLPRAVPQGPTEL----LQPP--SPAPGAAGTGSDallalldplntaws 810
Cdd:pfam03154 307 SQVPPGPSPAAPGQSqQRIHTPPSQSQLQSQQPPREQPLPPAPLsmphIKPPptTPIPQLPNPQSH-------------- 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 811 gstipSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMP----LSSTPARPFG-------TPPASLG 879
Cdd:pfam03154 373 -----KHPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPqsqqLPPPPAQPPVltqsqslPPPAASH 447
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 880 PAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPlgPPAVAPSRIRTLPLARSSARAAEAKQGLALR 959
Cdd:pfam03154 448 PPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQP--PSSASVSSSGPVPAAVSCPLPPVQIKEEALD 525
|
330 340
....*....|....*....|...
gi 1907138268 960 PGESPLLPPRPPQSlqPTPQPSV 982
Cdd:pfam03154 526 EAEEPESPPPPPRS--PSPEPTV 546
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
651-994 |
5.00e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 51.09 E-value: 5.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 651 SLGQDDMAIPSKPSITSPekpSALLGTSPALPLRPQNQEGI--LSPSIKEETPIPTPGSITIPRPqgrKTPELGIVPPPP 728
Cdd:PHA03247 2500 GGGPPDPDAPPAPSRLAP---AILPDEPVGEPVHPRMLTWIrgLEELASDDAGDPPPPLPPAAPP---AAPDRSVPPPRP 2573
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 729 TARPaklqaaggplgdfsSEPLQMDRERQAALSPALLSGLLPRAVPQGP------------TELLQPPSPAPGAAGT--- 793
Cdd:PHA03247 2574 APRP--------------SEPAVTSRARRPDAPPQSARPRAPVDDRGDPrgpappsplppdTHAPDPPPPSPSPAANepd 2639
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 794 -GSDALLALLDPLNTAWSGSTI--------PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLS 864
Cdd:PHA03247 2640 pHPPPTVPPPERPRDDPAPGRVsrprrarrLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSAT 2719
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 865 STPARPFGTPPASLGPAYAPSILLSSSGFYAP--HRSQPNLSALSMPNLfGQIPMGAHTSPLQPLGPPAVAPSRIRTLPL 942
Cdd:PHA03247 2720 PLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTAGPPA-PAPPAAPAAGPPRRLTRPAVASLSESRESL 2798
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1907138268 943 ARSSARAAEAKQGLALRPGESPLLPPRPPQSLQPTPQPSVPTQARDPFEDLL 994
Cdd:PHA03247 2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL 2850
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
681-927 |
7.50e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 49.87 E-value: 7.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 681 LPLRPQNQEGILSPsikeetpiPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAGgplgdfSSEPLQMDRERQAAL 760
Cdd:PRK12323 361 LAFRPGQSGGGAGP--------ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA------AAAAARAVAAAPARR 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 761 SPAL--LSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVT 838
Cdd:PRK12323 427 SPAPeaLAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEF 506
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 839 PTPFVQtPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYAPSILLSSSGFYAPHRsqPNLSALSMPNLF-GQIPM 917
Cdd:PRK12323 507 ASPAPA-QPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRP--PRASASGLPDMFdGDWPA 583
|
250
....*....|
gi 1907138268 918 GAHTSPLQPL 927
Cdd:PRK12323 584 LAARLPVRGL 593
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
657-1001 |
2.97e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 48.24 E-value: 2.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 657 MAIPSKPSITSPEKPSALLGTSPALPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQ 736
Cdd:PHA03307 60 AACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLR 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 737 AAG--GPLGDFSSEPLQMDRERQAA-----LSPALLSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAW 809
Cdd:PHA03307 140 PVGspGPPPAASPPAAGASPAAVASdaassRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASS 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 810 SGSTIPSHPATPSAATPFIPQLSFPP-------TVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASlGPAY 882
Cdd:PHA03307 220 PAPAPGRSAADDAGASSSDSSSSESSgcgwgpeNECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRER-SPSP 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 883 APSillSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSRIRTLPlarssaraaeakqglalrPGE 962
Cdd:PHA03307 299 SPS---SPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS------------------RPP 357
|
330 340 350
....*....|....*....|....*....|....*....
gi 1907138268 963 SPLLPPRPPQSlqPTPQPSVPTQARDPFEDLLRKTKQDV 1001
Cdd:PHA03307 358 PPADPSSPRKR--PRPSRAPSSPAASAGRPTRRRARAAV 394
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
726-936 |
3.24e-05 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 47.58 E-value: 3.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 726 PPPTARPAKLQAAGGPLGDFSSEPLQMD---RERQAALSPALLSGLLPRAVPQGPTELLQPPSPApGAAGTGSDALLALL 802
Cdd:COG5651 165 TPFTQPPPTITNPGGLLGAQNAGSGNTSsnpGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNT-GFAGTGAAAGAAAA 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 803 DPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMP----LSSTPARPFGTPPASL 878
Cdd:COG5651 244 AAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAaatgLGLGAGGAAGAAGATG 323
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1907138268 879 GPAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSR 936
Cdd:COG5651 324 AGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGG 381
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
659-929 |
1.49e-04 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 45.69 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 659 IPSKPsiTSPEKPSALLGTSPAlPLRPQNQEGILSPSIKEetpiPTPGSITIPRPQGRKTPELGIVPPpptARPAKLQAA 738
Cdd:PLN03209 323 IPSQR--VPPKESDAADGPKPV-PTKPVTPEAPSPPIEEE----PPQPKAVVPRPLSPYTAYEDLKPP---TSPIPTPPS 392
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 739 GGPLGDFSSEPLQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPSPApgaagtgsdallalldplnTAWSGSTIPSHP 818
Cdd:PLN03209 393 SSPASSKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSPY-------------------ARYEDLKPPTSP 453
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 819 aTPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAyapsillSSSGFYAPHR 898
Cdd:PLN03209 454 -SPTAPTGVSPSVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPA-------APVGKVAPSS 525
|
250 260 270
....*....|....*....|....*....|..
gi 1907138268 899 SQPNLSALSMPNLFGQIPMGAHTSPLQ-PLGP 929
Cdd:PLN03209 526 TNEVVKVGNSAPPTALADEQHHAQPKPrPLSP 557
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
429-841 |
9.02e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.39 E-value: 9.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 429 SSAEDPLPKTMPSPQAETQDPRLREDRRPITVHFGQVRPPRPHV------VRRPKsNITVEGRRTSVSSPEHlvKPLRHY 502
Cdd:PHA03247 2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDdpapgrVSRPR-RARRLGRAAQASSPPQ--RPRRRA 2687
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 503 A------VFLSEDSSDEECRREEAPSTGFTESLLFSAPFEWPQ--PYRTLKESDSAEGDETESPEQLVREPWGPTPAPPD 574
Cdd:PHA03247 2688 ArptvgsLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQasPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP 2767
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 575 RAASIDLLEDVFSSLDVEAPLQPLgqAKSLEDLRAPKDLREQPGSFDYQRLDLCRSERGLSMAAALKLAHPytklwslgq 654
Cdd:PHA03247 2768 APAPPAAPAAGPPRRLTRPAVASL--SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP--------- 2836
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 655 ddmAIPSKPSITSPEKPSALLGTSPALPLRPQNQEGilSPSIKEETPiPTPGSITIPRPQGRKTPELGIVPPPPTARPAK 734
Cdd:PHA03247 2837 ---TAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR--SPAAKPAAP-ARPPVRRLARPAVSRSTESFALPPDQPERPPQ 2910
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 735 LQAAGGPLGDFSSEPlqmdrerqaalspallsglLPRAVPQGPTellQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 814
Cdd:PHA03247 2911 PQAPPPPQPQPQPPP-------------------PPQPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
|
410 420
....*....|....*....|....*..
gi 1907138268 815 PSHPATPSAATPfIPQLSFPPTVTPTP 841
Cdd:PHA03247 2969 PGRVAVPRFRVP-QPAPSREAPASSTP 2994
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
506-826 |
1.21e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 42.85 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 506 LSEDSSDEECRREEAPSTGFT--ESLLFSAPFEWPQPYRtlkESDSAEGDETESPEQLVREPWGPTPAPPDRAASIDLLE 583
Cdd:PHA03307 10 LIEAAAEGGEFFPRPPATPGDaaDDLLSGSQGQLVSDSA---ELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 584 DVFSSLDVEAPLQPLGQAKSLEDLRAPKDLREQPGSfdyqrLDLCRSERGLSMAAALKLAHPYTklwSLGQDDMAIPSKP 663
Cdd:PHA03307 87 TPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPP-----PASPPPSPAPDLSEMLRPVGSPG---PPPAASPPAAGAS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 664 SITSPEKPSALLGTSPALPLRPQNQEGILSPSikEETPIPTPGSITIPRPQGRKTPeLGIVPPPPTARPAKLQAAGGPLG 743
Cdd:PHA03307 159 PAAVASDAASSRQAALPLSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSP-ISASASSPAPAPGRSAADDAGAS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 744 DFSSEPLQM----DRERQAALSPALLSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALlalldplntawSGSTIPSHPA 819
Cdd:PHA03307 236 SSDSSSSESsgcgWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRER-----------SPSPSPSSPG 304
|
....*..
gi 1907138268 820 TPSAATP 826
Cdd:PHA03307 305 SGPAPSS 311
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
654-993 |
2.83e-03 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 41.58 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 654 QDDMAIPSKPSITSPEKPsallgTSPALPLRPQNQEGILSPSIKEETPiPTPGSITIPRPQGRKTPELGIVPPPPTARPA 733
Cdd:PHA03379 429 QSLETATSHGSAQVPEPP-----PVHDLEPGPLHDQHSMAPCPVAQLP-PGPLQDLEPGDQLPGVVQDGRPACAPVPAPA 502
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 734 klqaaGGPLGDFSSEPLQMDRERQAALSPALLSGllpRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGST 813
Cdd:PHA03379 503 -----GPIVRPWEASLSQVPGVAFAPVMPQPMPV---EPVPVPTVALERPVCPAPPLIAMQGPGETSGIVRVRERWRPAP 574
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 814 IPSHPATPSAATPFIPQLS----------FPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYA 883
Cdd:PHA03379 575 WTPNPPRSPSQMSVRDRLArlraeaqpyqASVEVQPPQLTQVSPQQPMEYPLEPEQQMFPGSPFSQVADVMRAGGVPAMQ 654
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 884 PsillsssgfyaPHRSQPnlsaLSMPNLFGQ--IPMGAHTSPLQPLgpPAVAPSRIRtLPLARSSARAAEAKQGLALRPG 961
Cdd:PHA03379 655 P-----------QYFDLP----LQQPISQGAplAPLRASMGPVPPV--PATQPQYFD-IPLTEPINQGASAAHFLPQQPM 716
|
330 340 350
....*....|....*....|....*....|..
gi 1907138268 962 ESPLLPPRPPQSLQPTPQPSVPTQARDPFEDL 993
Cdd:PHA03379 717 EGPLVPERWMFQGATLSQSVRPGVAQSQYFDL 748
|
|
| uDENN |
pfam03456 |
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ... |
31-57 |
5.47e-03 |
|
uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.
Pssm-ID: 460926 Cd Length: 59 Bit Score: 36.05 E-value: 5.47e-03
|
| PRK12727 |
PRK12727 |
flagellar biosynthesis protein FlhF; |
716-891 |
6.43e-03 |
|
flagellar biosynthesis protein FlhF;
Pssm-ID: 237182 [Multi-domain] Cd Length: 559 Bit Score: 40.36 E-value: 6.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 716 RKTPELGIVPPPPTARPAKLQAAGGPLGDFSSEPLQMDRERQAALSPALLSGL-------LPRAVPQG-PTELLQPPSPA 787
Cdd:PRK12727 60 SDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMalrqpvsVPRQAPAAaPVRAASIPSPA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138268 788 PGAAGTGSDALLALLDPLNTAWSGSTI-------PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPS 860
Cdd:PRK12727 140 AQALAHAAAVRTAPRQEHALSAVPEQLfadflttAPVPRAPVQAPVVAAPAPVPAIAAALAAHAAYAQDDDEQLDDDGFD 219
|
170 180 190
....*....|....*....|....*....|..
gi 1907138268 861 MPLSSTPA-RPFGTPPASLGPAyAPSILLSSS 891
Cdd:PRK12727 220 LDDALPQIlPPAALPPIVVAPA-APAALAAVA 250
|
|
| |
