|
Name |
Accession |
Description |
Interval |
E-value |
| Aquarius_N |
pfam16399 |
Intron-binding protein aquarius N-terminus; This family represents the N-terminus of ... |
21-806 |
0e+00 |
|
Intron-binding protein aquarius N-terminus; This family represents the N-terminus of intron-binding protein aquarius, a splicing factor which links excision of introns from pre-mRNA with snoRP assembly.
Pssm-ID: 435319 Cd Length: 791 Bit Score: 1198.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 21 INAEYVTQLANKYWAPHAK-NKLPFDPKVMEDVYEKEILKSKFAIRKIMLLEFSQYLENYLWVNYAPKvSSNAYLMSICC 99
Cdd:pfam16399 1 IQEDRIAQLARKHWLKSKKsKKVKVKPEVVKKIYWDELEKEGFSLRSLLLLEFLQYLENYLWPNYTED-ASNAHVLLIVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 100 IVNEKFRENVPAWEVFKKEPSHFPFFFKCVMEASLADEkacLTLKEQTVLLVFLDHCFNSLEVDLIREQVQQLIALPMWM 179
Cdd:pfam16399 80 MVNEKFREHLPAWELFSDRPDDFSSFFRRVLSLSLDRS---LSTAERTALLSFLIHAFQSLENELVRKECAPLVSISIWH 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 180 CL-LPSRLQQELKKVPKLQKFWNLIKKKCDKMDAESAEQAKKERTFLSALIKKFLGVLMSIPPSGPVSMDKVHYCERFIE 258
Cdd:pfam16399 157 NLsSEGRREQELDKNPQLRKAWRAAQKRYDAADDATKARLRFERSWLYTLLLDFLDVLYDIPEDGEVDDDNVRYCERFLE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 259 LMIDLEALLPTRRWFNTVLDDSHLVVSCHLSSLTQREkEGHLFCQLLDMLKFYTGFEINDQTGNALTEKEMTTLHYDKIL 338
Cdd:pfam16399 237 LLIDLESQLPTRRYVNTLLQDLHLLPACRLSPLYNDE-EGGLFRQLLDLLKHYTYFEIDDQTGEQLSDQEVYDAHYARLA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 339 SLQRAAFAHFPE-LQDFALSNVAAVDTRESLMKHFGHLSPNTLHQVASYLCL-LPELPEGQDTTYEKEVLLELLVSRHER 416
Cdd:pfam16399 316 RLQRTAFKHFKEkLTILALSNYGSIDKREELEKHLSALSDEELRELCSLLGLrTVPYPESDNIVYDRKFLLEVLLSRFEK 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 417 RISQIEQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDVVWRMK 496
Cdd:pfam16399 396 RPSQQEAANELPLYPTEKTLWDENLVRTEYYDGSRPLALPKLNLQYLTLGDFLLRNFNLFRLESFYEIRQDIEDAVKRLK 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 497 PWQSEYGGAVFGGWARMAQMITSFSIVEVAKPNIGESWPARVRADVTVNL-NVQDHIKHEWEGLRKHDVCLLITVRPNLP 575
Cdd:pfam16399 476 PRLGEDGETRFGGWSRMALPISKPAIVEVAPPNVGESKPSRVRAEVTIDVsRLRDNIRREWESLRPHDVVFLLAVRPPDE 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 576 YGTRFDRRQPFVEQTGLVYVRGCEVQGMLDDKGRVIEE------GPDPKPKLrgdaRTFRVWLDPNQYQQDMTsSIQSGT 649
Cdd:pfam16399 556 TYNKLTGSQSFAEQLGLVYVRGAEVIQVLDENGRVLREpqgqtnGPEPRPRQ----RRLRVRLDANQYKADMD-RAAEGK 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 650 EDPYETFNIIMRRKPKENNFKAVLETIRNLMNTECVVPDWLHDIILGYGDPGSAHYSKMPNQISTLDFNDTFLSLDHLHL 729
Cdd:pfam16399 631 PDVYETFNVLVRRKPRENNFKAVLETIRDLMNSDCVVPDWLHDVFLGYGDPAAAHYKNLPNRLKTVDFRDTFLDWQHLIE 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 730 CFPGYTIKVTEENPDLQVFPFRITFPISNKAD----KVKKRKADDEVEDKEEDMTLIVEPYVTLNRGPYPYNQPKRNTIQ 805
Cdd:pfam16399 711 SFPGKTIEPSDDVSGSFGPPYVLEFPDSPPEPapakPSKKRRRDQEPAPQAEPETIRVSTYKPPNRGPYPVDAPKLNSVR 790
|
.
gi 1811574662 806 F 806
Cdd:pfam16399 791 F 791
|
|
| EEXXQc_AQR |
cd17935 |
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds ... |
801-1156 |
3.02e-127 |
|
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds precursor-mRNA introns at a defined position and is part of a pentameric intron-binding complex (IBC). It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350693 [Multi-domain] Cd Length: 207 Bit Score: 392.95 E-value: 3.02e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 801 RNTIQFTPTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNLYHNFPEQRTLIVTHSNQALNQLFEKIMALDIDERHL 880
Cdd:cd17935 1 QNTVKFTPTQIEAIRSGMQPGLTMVVGPPGTGKTDVAVQIISNLYHNFPNQRTLIVTHSNQALNQLFEKIMALDIDERHL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 881 LRLGHGeeeletekdfsrygrvnyvlarrlellrevgrlqesldvpgdvsytcetaghfylyqvisrweeymskvkpkqg 960
Cdd:cd17935 81 LRLGHG-------------------------------------------------------------------------- 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 961 ktvevqavaahfpfhkyfsnapqpvfkgrsyeeemdiaegcyrhikkiftqleefrafellrsgldrskyllvkeAKIIA 1040
Cdd:cd17935 87 ---------------------------------------------------------------------------AKIIA 91
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1041 MTCTHAALKRHDLVELGFKYDNILMEEAAQILEIETFIPLLLQNPEDGYSRLKRWIMIGDHHQLPPVIKNMAFQKYSNME 1120
Cdd:cd17935 92 MTCTHAALKRGELVELGFKYDNILMEEAAQILEIETFIPLLLQNPEDGPNRLKRLIMIGDHHQLPPVIKNMAFQKYSNME 171
|
330 340 350
....*....|....*....|....*....|....*.
gi 1811574662 1121 QSLFTRFVRLGVPTIDLDAQGRARASLCNLYNWRYK 1156
Cdd:cd17935 172 QSLFTRLVRLGVPTVDLDAQGRARASISSLYNWRYK 207
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
1144-1327 |
2.35e-48 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 170.49 E-value: 2.35e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1144 RASLCNLYNWRYKHLGNLPHVQ-QLPEFQVPNPGLTFDFQLINVEdfnGVGESEPNPYFYQNLAEAEYTVALYMYMRLLG 1222
Cdd:cd18808 2 HPEISEFPSKLFYEGKLKAGVSvAARLNPPPLPGPSKPLVFVDVS---GGEEREESGTSKSNEAEAELVVELVKYLLKSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1223 YPADRISILTTYNGQKHLIRDVINQRCAGNPFFsqpnKVTTVDRFQGQQNDYIILSLVRTK----AVGHLRDVRRLVVAM 1298
Cdd:cd18808 79 VKPSSIGVITPYRAQVALIRELLRKRGGLLEDV----EVGTVDNFQGREKDVIILSLVRSNesggSIGFLSDPRRLNVAL 154
|
170 180
....*....|....*....|....*....
gi 1811574662 1299 SRARLGLYIFARVALFQNCFELTPVFNQL 1327
Cdd:cd18808 155 TRAKRGLIIVGNPDTLSKDPLWKKLLEYL 183
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
849-1316 |
5.27e-36 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 148.35 E-value: 5.27e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 849 PEQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLARRLELLREVGRLQESLDVPGD 928
Cdd:COG1112 355 ALLRLLAALLLALALLLLLALEELLLLALLRLLAEGLALLLLLLLAALLRLARALLLLALLLAAAAAALAALLLLALALL 434
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 929 VSYTCETAGHFYLYQVISRWEEYMSKVKPKQGKTVEVQAVAAHFPFHKYFSNAPQPVFKGRSYEEEMDIAEGCyRHIKKI 1008
Cdd:COG1112 435 AALLALLLLLAAALAALLALLLLLLLALAALLLLLAAAAALLALALLESLLEELIEEHPEELEKLIAELREAA-RLRRAL 513
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1009 FTQLEEFRAFELLRSgldrskYLLVKEAKIIAMTCthAALKRHDLVELGfKYDNILMEEAAQILEIETFIPLllqnpedg 1088
Cdd:COG1112 514 RRELKKRRELRKLLW------DALLELAPVVGMTP--ASVARLLPLGEG-SFDLVIIDEASQATLAEALGAL-------- 576
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1089 ySRLKRWIMIGDHHQLPPVIK--NMAFQKYSNMEQSLFTRFV-RLGVPTIDLDAQGRARASLCNLYNWR-YK-HLGNLPH 1163
Cdd:COG1112 577 -ARAKRVVLVGDPKQLPPVVFgeEAEEVAEEGLDESLLDRLLaRLPERGVMLREHYRMHPEIIAFSNRLfYDgKLVPLPS 655
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1164 VQQLPeFQVPNPGLTFdfqlINVEdfnGVGESEPNPYFyqNLAEAEYTVALYMYMRLLGYPADRISILTTYNGQKHLIRD 1243
Cdd:COG1112 656 PKARR-LADPDSPLVF----IDVD---GVYERRGGSRT--NPEEAEAVVELVRELLEDGPDGESIGVITPYRAQVALIRE 725
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1244 VINQRCAGNPffsQPNKVTTVDRFQGQQNDYIILSLVRTKAVGHLR-------DVRRLVVAMSRARLGLYIFARVALFQN 1316
Cdd:COG1112 726 LLREALGDGL---EPVFVGTVDRFQGDERDVIIFSLVYSNDEDVPRnfgflngGPRRLNVAVSRARRKLIVVGSRELLDS 802
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
794-1302 |
7.21e-30 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 127.62 E-value: 7.21e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 794 YPYNQPKRNTIQFTP-------TQIEAIR-AGMQPGLTMVVGPPGTGKTDVAVQIISNLYHNFPeqRTLIVTHSNQALNQ 865
Cdd:TIGR00376 139 REAPSKASEIHDFQFfdpnlneSQKEAVLfALSSKDLFLIHGPPGTGKTRTVVELIRQLVKRGL--RVLVTAPSNIAVDN 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 866 LFEKIMALDIderHLLRLGHGeeeletekdfsrygrvnyvlARRLELLrevgrLQESLDVpgdvsytcetaghfylyqVI 945
Cdd:TIGR00376 217 LLERLALCDQ---KIVRLGHP--------------------ARLLKSN-----KQHSLDY------------------LI 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 946 SRWEEYmSKVKPKQGKTVEVqavaahfpfhkyfsnapqpvfkgrsyEEEMDiaegcyRHIKKiFTQLEEFRA-FELLRSG 1024
Cdd:TIGR00376 251 ENHPKY-QIVADIREKIDEL--------------------------IEERN------KKTKP-SPQKRRGLSdIKILRKA 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1025 LDRSKYLLVKEAKIIAM---TCTHAALKR---------------------------HDLVELGFKYDNILMEEAAQILEI 1074
Cdd:TIGR00376 297 LKKREARGIESLKIASMaewIETNKSIDRllkllpeseerimneilaesdatnsmaGSEILNGQYFDVAVIDEASQAMEP 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1075 ETFIPLLlqnpedgysRLKRWIMIGDHHQLPPVIKNmafQKYSNMEQSLFTRFVRL-GVPTIDLDAQGRARASLC----- 1148
Cdd:TIGR00376 377 SCLIPLL---------KARKLILAGDHKQLPPTILS---HDAEELSLTLFERLIKEyPERSRTLNVQYRMNQKIMefpsr 444
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1149 NLYNWRYKH--------LGNLPHVQQLPEFQVPNPGLTfdFQLINVEDFNGVGESEPNPYFYQNLAEAEYTVALYMYMRL 1220
Cdd:TIGR00376 445 EFYNGKLTAhesvanilLRDLPKVEATESEDDLETGIP--LLFIDTSGCELFELKEADSTSKYNPGEAELVSEIIQALVK 522
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1221 LGYPADRISILTTYNGQKHLIRDVINQRcagnpffsQPN-KVTTVDRFQGQQNDYIILSLVRTK---AVGHLRDVRRLVV 1296
Cdd:TIGR00376 523 MGVPANDIGVITPYDAQVDLLRQLLEHR--------HIDiEVSSVDGFQGREKEVIIISFVRSNrkgEVGFLKDLRRLNV 594
|
....*.
gi 1811574662 1297 AMSRAR 1302
Cdd:TIGR00376 595 ALTRAR 600
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
1119-1307 |
1.17e-27 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 111.49 E-value: 1.17e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1119 MEQSLFTRFVRLG-VPTIDLDAQGRARASLCNLYN-WRYKhlGNL---PHVQQLPEFQVPNPGLTFD-FQLINVEDFNGV 1192
Cdd:pfam13087 1 LDRSLFERLQELGpSAVVMLDTQYRMHPEIMEFPSkLFYG--GKLkdgPSVAERPLPDDFHLPDPLGpLVFIDVDGSEEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1193 GESEPNPYFyqNLAEAEYTVALYMYMRLLGYPADR-ISILTTYNGQKHLIRDVINQRCAGNPFFsqpnKVTTVDRFQGQQ 1271
Cdd:pfam13087 79 ESDGGTSYS--NEAEAELVVQLVEKLIKSGPEEPSdIGVITPYRAQVRLIRKLLKRKLGGKLEI----EVNTVDGFQGRE 152
|
170 180 190
....*....|....*....|....*....|....*....
gi 1811574662 1272 NDYIILSLVRT---KAVGHLRDVRRLVVAMSRARLGLYI 1307
Cdd:pfam13087 153 KDVIIFSCVRSnekGGIGFLSDPRRLNVALTRAKRGLII 191
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
809-1111 |
1.86e-24 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 103.96 E-value: 1.86e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 809 TQIEAIRAGM-QPGLTMVVGPPGTGKTDVAVQIISNLY-----HNFPEQRTLIVTHSNQALNQLFEKIMALDID-ERHLL 881
Cdd:pfam13086 1 SQREAIRSALsSSHFTLIQGPPGTGKTTTIVELIRQLLsypatSAAAGPRILVCAPSNAAVDNILERLLRKGQKyGPKIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 882 RLGHGEEELETEKDFSRYGRVN--YVLARRLELLREVGRLQESLdvpgdvsytcetaghfylyqvisrweEYMSKVKPKQ 959
Cdd:pfam13086 81 RIGHPAAISEAVLPVSLDYLVEskLNNEEDAQIVKDISKELEKL--------------------------AKALRAFEKE 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 960 GKTVEVQAVAAHFPfhkyfsnapqpvfkgRSYEEEmdiAEGCYRHIKKIFTQLEEFRAFeLLRSGLDrskyllvkEAKII 1039
Cdd:pfam13086 135 IIVEKLLKSRNKDK---------------SKLEQE---RRKLRSERKELRKELRRREQS-LEREILD--------EAQIV 187
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1811574662 1040 AMTCTHAAlkRHDLVELgFKYDNILMEEAAQILEIETFIPLLLqnpedgysRLKRWIMIGDHHQLPPVIKNM 1111
Cdd:pfam13086 188 CSTLSGAG--SRLLSSL-ANFDVVIIDEAAQALEPSTLIPLLR--------GPKKVVLVGDPKQLPPTVISK 248
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
799-919 |
6.33e-07 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 51.72 E-value: 6.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 799 PKRNTIQFTPTQIEAIRAGMQ-PGLTMVVGPPGTGKTDVAVQIISNLYHNFPEQRTLIVTHSNQALNQLFEKIMAL--DI 875
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSgLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLgpSL 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1811574662 876 DERHLLRLGhGEEELETEKDFSR---------YGRVNYVLARRLELLREVGRL 919
Cdd:smart00487 82 GLKVVGLYG-GDSKREQLRKLESgktdilvttPGRLLDLLENDKLSLSNVDLV 133
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
810-870 |
3.40e-06 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 51.56 E-value: 3.40e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1811574662 810 QIEAIRA-------GMQPGLtmVVGPPGTGKTDVAVQIISNLYHNfpeQRTLIVTHSNQALNQLFEKI 870
Cdd:COG1061 85 QQEALEAllaalerGGGRGL--VVAPTGTGKTVLALALAAELLRG---KRVLVLVPRRELLEQWAEEL 147
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Aquarius_N |
pfam16399 |
Intron-binding protein aquarius N-terminus; This family represents the N-terminus of ... |
21-806 |
0e+00 |
|
Intron-binding protein aquarius N-terminus; This family represents the N-terminus of intron-binding protein aquarius, a splicing factor which links excision of introns from pre-mRNA with snoRP assembly.
Pssm-ID: 435319 Cd Length: 791 Bit Score: 1198.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 21 INAEYVTQLANKYWAPHAK-NKLPFDPKVMEDVYEKEILKSKFAIRKIMLLEFSQYLENYLWVNYAPKvSSNAYLMSICC 99
Cdd:pfam16399 1 IQEDRIAQLARKHWLKSKKsKKVKVKPEVVKKIYWDELEKEGFSLRSLLLLEFLQYLENYLWPNYTED-ASNAHVLLIVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 100 IVNEKFRENVPAWEVFKKEPSHFPFFFKCVMEASLADEkacLTLKEQTVLLVFLDHCFNSLEVDLIREQVQQLIALPMWM 179
Cdd:pfam16399 80 MVNEKFREHLPAWELFSDRPDDFSSFFRRVLSLSLDRS---LSTAERTALLSFLIHAFQSLENELVRKECAPLVSISIWH 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 180 CL-LPSRLQQELKKVPKLQKFWNLIKKKCDKMDAESAEQAKKERTFLSALIKKFLGVLMSIPPSGPVSMDKVHYCERFIE 258
Cdd:pfam16399 157 NLsSEGRREQELDKNPQLRKAWRAAQKRYDAADDATKARLRFERSWLYTLLLDFLDVLYDIPEDGEVDDDNVRYCERFLE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 259 LMIDLEALLPTRRWFNTVLDDSHLVVSCHLSSLTQREkEGHLFCQLLDMLKFYTGFEINDQTGNALTEKEMTTLHYDKIL 338
Cdd:pfam16399 237 LLIDLESQLPTRRYVNTLLQDLHLLPACRLSPLYNDE-EGGLFRQLLDLLKHYTYFEIDDQTGEQLSDQEVYDAHYARLA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 339 SLQRAAFAHFPE-LQDFALSNVAAVDTRESLMKHFGHLSPNTLHQVASYLCL-LPELPEGQDTTYEKEVLLELLVSRHER 416
Cdd:pfam16399 316 RLQRTAFKHFKEkLTILALSNYGSIDKREELEKHLSALSDEELRELCSLLGLrTVPYPESDNIVYDRKFLLEVLLSRFEK 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 417 RISQIEQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDVVWRMK 496
Cdd:pfam16399 396 RPSQQEAANELPLYPTEKTLWDENLVRTEYYDGSRPLALPKLNLQYLTLGDFLLRNFNLFRLESFYEIRQDIEDAVKRLK 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 497 PWQSEYGGAVFGGWARMAQMITSFSIVEVAKPNIGESWPARVRADVTVNL-NVQDHIKHEWEGLRKHDVCLLITVRPNLP 575
Cdd:pfam16399 476 PRLGEDGETRFGGWSRMALPISKPAIVEVAPPNVGESKPSRVRAEVTIDVsRLRDNIRREWESLRPHDVVFLLAVRPPDE 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 576 YGTRFDRRQPFVEQTGLVYVRGCEVQGMLDDKGRVIEE------GPDPKPKLrgdaRTFRVWLDPNQYQQDMTsSIQSGT 649
Cdd:pfam16399 556 TYNKLTGSQSFAEQLGLVYVRGAEVIQVLDENGRVLREpqgqtnGPEPRPRQ----RRLRVRLDANQYKADMD-RAAEGK 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 650 EDPYETFNIIMRRKPKENNFKAVLETIRNLMNTECVVPDWLHDIILGYGDPGSAHYSKMPNQISTLDFNDTFLSLDHLHL 729
Cdd:pfam16399 631 PDVYETFNVLVRRKPRENNFKAVLETIRDLMNSDCVVPDWLHDVFLGYGDPAAAHYKNLPNRLKTVDFRDTFLDWQHLIE 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 730 CFPGYTIKVTEENPDLQVFPFRITFPISNKAD----KVKKRKADDEVEDKEEDMTLIVEPYVTLNRGPYPYNQPKRNTIQ 805
Cdd:pfam16399 711 SFPGKTIEPSDDVSGSFGPPYVLEFPDSPPEPapakPSKKRRRDQEPAPQAEPETIRVSTYKPPNRGPYPVDAPKLNSVR 790
|
.
gi 1811574662 806 F 806
Cdd:pfam16399 791 F 791
|
|
| EEXXQc_AQR |
cd17935 |
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds ... |
801-1156 |
3.02e-127 |
|
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds precursor-mRNA introns at a defined position and is part of a pentameric intron-binding complex (IBC). It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350693 [Multi-domain] Cd Length: 207 Bit Score: 392.95 E-value: 3.02e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 801 RNTIQFTPTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNLYHNFPEQRTLIVTHSNQALNQLFEKIMALDIDERHL 880
Cdd:cd17935 1 QNTVKFTPTQIEAIRSGMQPGLTMVVGPPGTGKTDVAVQIISNLYHNFPNQRTLIVTHSNQALNQLFEKIMALDIDERHL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 881 LRLGHGeeeletekdfsrygrvnyvlarrlellrevgrlqesldvpgdvsytcetaghfylyqvisrweeymskvkpkqg 960
Cdd:cd17935 81 LRLGHG-------------------------------------------------------------------------- 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 961 ktvevqavaahfpfhkyfsnapqpvfkgrsyeeemdiaegcyrhikkiftqleefrafellrsgldrskyllvkeAKIIA 1040
Cdd:cd17935 87 ---------------------------------------------------------------------------AKIIA 91
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1041 MTCTHAALKRHDLVELGFKYDNILMEEAAQILEIETFIPLLLQNPEDGYSRLKRWIMIGDHHQLPPVIKNMAFQKYSNME 1120
Cdd:cd17935 92 MTCTHAALKRGELVELGFKYDNILMEEAAQILEIETFIPLLLQNPEDGPNRLKRLIMIGDHHQLPPVIKNMAFQKYSNME 171
|
330 340 350
....*....|....*....|....*....|....*.
gi 1811574662 1121 QSLFTRFVRLGVPTIDLDAQGRARASLCNLYNWRYK 1156
Cdd:cd17935 172 QSLFTRLVRLGVPTVDLDAQGRARASISSLYNWRYK 207
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
1144-1327 |
2.35e-48 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 170.49 E-value: 2.35e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1144 RASLCNLYNWRYKHLGNLPHVQ-QLPEFQVPNPGLTFDFQLINVEdfnGVGESEPNPYFYQNLAEAEYTVALYMYMRLLG 1222
Cdd:cd18808 2 HPEISEFPSKLFYEGKLKAGVSvAARLNPPPLPGPSKPLVFVDVS---GGEEREESGTSKSNEAEAELVVELVKYLLKSG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1223 YPADRISILTTYNGQKHLIRDVINQRCAGNPFFsqpnKVTTVDRFQGQQNDYIILSLVRTK----AVGHLRDVRRLVVAM 1298
Cdd:cd18808 79 VKPSSIGVITPYRAQVALIRELLRKRGGLLEDV----EVGTVDNFQGREKDVIILSLVRSNesggSIGFLSDPRRLNVAL 154
|
170 180
....*....|....*....|....*....
gi 1811574662 1299 SRARLGLYIFARVALFQNCFELTPVFNQL 1327
Cdd:cd18808 155 TRAKRGLIIVGNPDTLSKDPLWKKLLEYL 183
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
849-1316 |
5.27e-36 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 148.35 E-value: 5.27e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 849 PEQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLARRLELLREVGRLQESLDVPGD 928
Cdd:COG1112 355 ALLRLLAALLLALALLLLLALEELLLLALLRLLAEGLALLLLLLLAALLRLARALLLLALLLAAAAAALAALLLLALALL 434
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 929 VSYTCETAGHFYLYQVISRWEEYMSKVKPKQGKTVEVQAVAAHFPFHKYFSNAPQPVFKGRSYEEEMDIAEGCyRHIKKI 1008
Cdd:COG1112 435 AALLALLLLLAAALAALLALLLLLLLALAALLLLLAAAAALLALALLESLLEELIEEHPEELEKLIAELREAA-RLRRAL 513
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1009 FTQLEEFRAFELLRSgldrskYLLVKEAKIIAMTCthAALKRHDLVELGfKYDNILMEEAAQILEIETFIPLllqnpedg 1088
Cdd:COG1112 514 RRELKKRRELRKLLW------DALLELAPVVGMTP--ASVARLLPLGEG-SFDLVIIDEASQATLAEALGAL-------- 576
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1089 ySRLKRWIMIGDHHQLPPVIK--NMAFQKYSNMEQSLFTRFV-RLGVPTIDLDAQGRARASLCNLYNWR-YK-HLGNLPH 1163
Cdd:COG1112 577 -ARAKRVVLVGDPKQLPPVVFgeEAEEVAEEGLDESLLDRLLaRLPERGVMLREHYRMHPEIIAFSNRLfYDgKLVPLPS 655
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1164 VQQLPeFQVPNPGLTFdfqlINVEdfnGVGESEPNPYFyqNLAEAEYTVALYMYMRLLGYPADRISILTTYNGQKHLIRD 1243
Cdd:COG1112 656 PKARR-LADPDSPLVF----IDVD---GVYERRGGSRT--NPEEAEAVVELVRELLEDGPDGESIGVITPYRAQVALIRE 725
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1244 VINQRCAGNPffsQPNKVTTVDRFQGQQNDYIILSLVRTKAVGHLR-------DVRRLVVAMSRARLGLYIFARVALFQN 1316
Cdd:COG1112 726 LLREALGDGL---EPVFVGTVDRFQGDERDVIIFSLVYSNDEDVPRnfgflngGPRRLNVAVSRARRKLIVVGSRELLDS 802
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
794-1302 |
7.21e-30 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 127.62 E-value: 7.21e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 794 YPYNQPKRNTIQFTP-------TQIEAIR-AGMQPGLTMVVGPPGTGKTDVAVQIISNLYHNFPeqRTLIVTHSNQALNQ 865
Cdd:TIGR00376 139 REAPSKASEIHDFQFfdpnlneSQKEAVLfALSSKDLFLIHGPPGTGKTRTVVELIRQLVKRGL--RVLVTAPSNIAVDN 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 866 LFEKIMALDIderHLLRLGHGeeeletekdfsrygrvnyvlARRLELLrevgrLQESLDVpgdvsytcetaghfylyqVI 945
Cdd:TIGR00376 217 LLERLALCDQ---KIVRLGHP--------------------ARLLKSN-----KQHSLDY------------------LI 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 946 SRWEEYmSKVKPKQGKTVEVqavaahfpfhkyfsnapqpvfkgrsyEEEMDiaegcyRHIKKiFTQLEEFRA-FELLRSG 1024
Cdd:TIGR00376 251 ENHPKY-QIVADIREKIDEL--------------------------IEERN------KKTKP-SPQKRRGLSdIKILRKA 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1025 LDRSKYLLVKEAKIIAM---TCTHAALKR---------------------------HDLVELGFKYDNILMEEAAQILEI 1074
Cdd:TIGR00376 297 LKKREARGIESLKIASMaewIETNKSIDRllkllpeseerimneilaesdatnsmaGSEILNGQYFDVAVIDEASQAMEP 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1075 ETFIPLLlqnpedgysRLKRWIMIGDHHQLPPVIKNmafQKYSNMEQSLFTRFVRL-GVPTIDLDAQGRARASLC----- 1148
Cdd:TIGR00376 377 SCLIPLL---------KARKLILAGDHKQLPPTILS---HDAEELSLTLFERLIKEyPERSRTLNVQYRMNQKIMefpsr 444
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1149 NLYNWRYKH--------LGNLPHVQQLPEFQVPNPGLTfdFQLINVEDFNGVGESEPNPYFYQNLAEAEYTVALYMYMRL 1220
Cdd:TIGR00376 445 EFYNGKLTAhesvanilLRDLPKVEATESEDDLETGIP--LLFIDTSGCELFELKEADSTSKYNPGEAELVSEIIQALVK 522
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1221 LGYPADRISILTTYNGQKHLIRDVINQRcagnpffsQPN-KVTTVDRFQGQQNDYIILSLVRTK---AVGHLRDVRRLVV 1296
Cdd:TIGR00376 523 MGVPANDIGVITPYDAQVDLLRQLLEHR--------HIDiEVSSVDGFQGREKEVIIISFVRSNrkgEVGFLKDLRRLNV 594
|
....*.
gi 1811574662 1297 AMSRAR 1302
Cdd:TIGR00376 595 ALTRAR 600
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
1119-1307 |
1.17e-27 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 111.49 E-value: 1.17e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1119 MEQSLFTRFVRLG-VPTIDLDAQGRARASLCNLYN-WRYKhlGNL---PHVQQLPEFQVPNPGLTFD-FQLINVEDFNGV 1192
Cdd:pfam13087 1 LDRSLFERLQELGpSAVVMLDTQYRMHPEIMEFPSkLFYG--GKLkdgPSVAERPLPDDFHLPDPLGpLVFIDVDGSEEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1193 GESEPNPYFyqNLAEAEYTVALYMYMRLLGYPADR-ISILTTYNGQKHLIRDVINQRCAGNPFFsqpnKVTTVDRFQGQQ 1271
Cdd:pfam13087 79 ESDGGTSYS--NEAEAELVVQLVEKLIKSGPEEPSdIGVITPYRAQVRLIRKLLKRKLGGKLEI----EVNTVDGFQGRE 152
|
170 180 190
....*....|....*....|....*....|....*....
gi 1811574662 1272 NDYIILSLVRT---KAVGHLRDVRRLVVAMSRARLGLYI 1307
Cdd:pfam13087 153 KDVIIFSCVRSnekGGIGFLSDPRRLNVALTRAKRGLII 191
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
809-1111 |
1.86e-24 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 103.96 E-value: 1.86e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 809 TQIEAIRAGM-QPGLTMVVGPPGTGKTDVAVQIISNLY-----HNFPEQRTLIVTHSNQALNQLFEKIMALDID-ERHLL 881
Cdd:pfam13086 1 SQREAIRSALsSSHFTLIQGPPGTGKTTTIVELIRQLLsypatSAAAGPRILVCAPSNAAVDNILERLLRKGQKyGPKIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 882 RLGHGEEELETEKDFSRYGRVN--YVLARRLELLREVGRLQESLdvpgdvsytcetaghfylyqvisrweEYMSKVKPKQ 959
Cdd:pfam13086 81 RIGHPAAISEAVLPVSLDYLVEskLNNEEDAQIVKDISKELEKL--------------------------AKALRAFEKE 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 960 GKTVEVQAVAAHFPfhkyfsnapqpvfkgRSYEEEmdiAEGCYRHIKKIFTQLEEFRAFeLLRSGLDrskyllvkEAKII 1039
Cdd:pfam13086 135 IIVEKLLKSRNKDK---------------SKLEQE---RRKLRSERKELRKELRRREQS-LEREILD--------EAQIV 187
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1811574662 1040 AMTCTHAAlkRHDLVELgFKYDNILMEEAAQILEIETFIPLLLqnpedgysRLKRWIMIGDHHQLPPVIKNM 1111
Cdd:pfam13086 188 CSTLSGAG--SRLLSSL-ANFDVVIIDEAAQALEPSTLIPLLR--------GPKKVVLVGDPKQLPPTVISK 248
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
1038-1141 |
4.35e-23 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 96.02 E-value: 4.35e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1038 IIAMTCTHAALKRhdlvelgfkYDNILMEEAAQILEIETFIPlllqnpEDGYSRLKRWIMIGDHHQLPPVIKNMAFQKYS 1117
Cdd:cd17914 34 ILLVTPTNKAAAQ---------LDNILVDEAAQILEPETSRL------IDLALDQGRVILVGDHDQLGPVWRGAVLAKIC 98
|
90 100
....*....|....*....|....
gi 1811574662 1118 NmEQSLFTRFVRLGVPTIDLDAQG 1141
Cdd:cd17914 99 N-EQSLFTRLVRLGVSLIRLQVQY 121
|
|
| DEXXQc_UPF1 |
cd18039 |
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of ... |
808-1142 |
1.08e-22 |
|
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of Nonsense Transcripts, or ATP-Dependent Helicase RENT1) is an RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. It is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. It is recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) located downstream from the termination codon through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Diseases associated with UPF1 include juvenile amyotrophic lateral sclerosis and epidermolysis bullosa, junctional, non-Herlitz type. UPF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350797 [Multi-domain] Cd Length: 234 Bit Score: 98.47 E-value: 1.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 808 PTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNLYHNFPEQrTLIVTHSNQALNQLFEKImaldiDERHLlrlghge 887
Cdd:cd18039 4 HSQVDAVKTALQRPLSLIQGPPGTGKTVTSATIVYHLVKQGNGP-VLVCAPSNVAVDQLTEKI-----HQTGL------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 888 eeletekdfsrygRVNYVLARRlellREvgrlqeslDVPGDVSYTCEtagHFYLYQVISrweeyMSKVKPKQGKTVEVqa 967
Cdd:cd18039 71 -------------KVVRLCAKS----RE--------AVESPVSFLAL---HNQVRNLDS-----AEKLELLKLLKLET-- 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 968 vaahfpfhkyfsnapqpvfkgrsyeEEMDIAEgcYRHIKKIFTQLEEfrafELLRsgldrskyllvkEAKIIAMTCTHAA 1047
Cdd:cd18039 116 -------------------------GELSSAD--EKRYRKLKRKAER----ELLR------------NADVICCTCVGAG 152
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1048 LKRhdLVelGFKYDNILMEEAAQILEIETFIPLLLQnpedgysrLKRWIMIGDHHQLPPVIKNMAFQKYSnMEQSLFTRF 1127
Cdd:cd18039 153 DPR--LS--KMKFRTVLIDEATQATEPECLIPLVHG--------AKQVILVGDHCQLGPVVMCKKAAKAG-LSQSLFERL 219
|
330
....*....|....*
gi 1811574662 1128 VRLGVPTIDLDAQGR 1142
Cdd:cd18039 220 VQLGIRPIRLQVQYR 234
|
|
| DEXXQc_SETX |
cd18042 |
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ... |
1015-1142 |
7.50e-20 |
|
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438712 [Multi-domain] Cd Length: 218 Bit Score: 89.97 E-value: 7.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1015 FRAFELLRSGLDRSKYLLVKEAKIIAmtCTHAALKRHDLVELGFKYDNILMEEAAQILEIETFIPLLLqnpedgysRLKR 1094
Cdd:cd18042 102 SYKPNVVRVGRQELRASILNEADIVC--TTLSSSGSDLLESLPRGFDTVIIDEAAQAVELSTLIPLRL--------GCKR 171
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1811574662 1095 WIMIGDHHQLPPVIKNMAFQKYsNMEQSLFTRFVRLGVPTIDLDAQGR 1142
Cdd:cd18042 172 LILVGDPKQLPATVFSKVAQKL-GYDRSLFERLQLAGYPVLMLTTQYR 218
|
|
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
810-1154 |
3.03e-17 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 82.67 E-value: 3.03e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 810 QIEAIRA----GMQPGLTMVVGPPGTGKTDVAVQIISNLYHNFPEQRTLIVTHSNQALNQLfekimaldiderhLLRLgh 885
Cdd:cd18038 6 QKLAVRNivtgTSRPPPYIIFGPPGTGKTVTLVEAILQVLRQPPEARILVCAPSNSAADLL-------------AERL-- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 886 geeeletekdfsrygrVNYVLARRlELLRevgrlqesldvpgdvsytcetaghfyLYQVISRWEEYMSKVKPkqgktvev 965
Cdd:cd18038 71 ----------------LNALVTKR-EILR--------------------------LNAPSRDRASVPPELLP-------- 99
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 966 qavaahfpfhkYFSNapqpvfkgrsyeeemdIAEGCYRHIkkiftQLEEfrafellrsgldrskyllVKEAKIIAMTCTH 1045
Cdd:cd18038 100 -----------YCNS----------------KAEGTFRLP-----SLEE------------------LKKYRIVVCTLMT 129
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1046 AALkrhdLVELGFK---YDNILMEEAAQILEIETFIPLLLQNPEDGysrlkRWIMIGDHHQLPPVIKNMAFQKYsNMEQS 1122
Cdd:cd18038 130 AGR----LVQAGVPnghFTHIFIDEAGQATEPEALIPLSELASKNT-----QIVLAGDPKQLGPVVRSPLARKY-GLGKS 199
|
330 340 350
....*....|....*....|....*....|..
gi 1811574662 1123 LFTRFVRLGVPTIDLDAQGRARASLCNlyNWR 1154
Cdd:cd18038 200 LLERLMERPLYYKDGEYNPSYITKLLK--NYR 229
|
|
| EEXXEc_NFX1 |
cd17936 |
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that ... |
808-1140 |
1.73e-15 |
|
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that represses class II MHC (major histocompatibility complex) gene expression. NFX1 binds a conserved cis-acting element, termed the X-box, in promoters of human class II MHC genes. The Cys-rich region contains several NFX1-type zinc finger domains. Frequently, a R3H domain is present in the C-terminus, and a RING finger domain and a PAM2 motif are present in the N-terminus. The lack of R3H and PAM2 motifs in the plant proteins indicates functional differences. Plant NFX1-like proteins are proposed to modulate growth and survival by coordinating reactive oxygen species, salicylic acid, further biotic stress and abscisic acid responses. A common feature of all members may be E3 ubiquitin ligase, due to the presence of a RING finger domain, as well as DNA binding. NFX1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350694 [Multi-domain] Cd Length: 178 Bit Score: 76.04 E-value: 1.73e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 808 PTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNLYHNFPEQRT---LIVTHSNQALNQLFEKImaLDIDERHLLRLG 884
Cdd:cd17936 4 PSQLEALKHALTSELALIQGPPGTGKTFLGVKLVRALLQNQDLSITgpiLVVCYTNHALDQFLEGL--LDFGPTKIVRLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 885 hgeeeletekdfsrygrvnyvlarrlellrevgrlqesldvpgdvsytcetaghfylyqvisrweeymskvkpkqgktve 964
Cdd:cd17936 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 965 vqavaahfpfhkyfsnapqpvfkgrsyeeemdiaegcyrhikkiftqleefrafellrsgldrskyllvkeAKIIAMTCT 1044
Cdd:cd17936 82 -----------------------------------------------------------------------ARVIGMTTT 90
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1045 HAALKRHDLVELGFKYdnILMEEAAQILE--IETFIPlllqnpedgySRLKRWIMIGDHHQLPPVIKNMAFQ--KYsNME 1120
Cdd:cd17936 91 GAAKYRELLQALGPKV--VIVEEAAEVLEahILAALT----------PSTEHLILIGDHKQLRPKVNVYELTakKY-NLD 157
|
330 340
....*....|....*....|
gi 1811574662 1121 QSLFTRFVRLGVPTIDLDAQ 1140
Cdd:cd17936 158 VSLFERLVKNGLPFVTLNVQ 177
|
|
| DEXXc_HELZ2-C |
cd18040 |
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
808-1127 |
9.62e-13 |
|
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350798 [Multi-domain] Cd Length: 271 Bit Score: 70.25 E-value: 9.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 808 PTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIIsnlYHnFPEQrtlivthsNQALNQLFEKIMALDiderHLLRLGHGE 887
Cdd:cd18040 4 PSQNHAVRTALTKPFTLIQGPPGTGKTVTGVHIA---YW-FAKQ--------NREIQSVSGEGDGGP----CVLYCGPSN 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 888 EELETekdfsrygrVNYVLARRLEL--LREVGRLQESLDVPgdvsytcetaghfylyqvISRWEEYMSKVKPKQGK-TVE 964
Cdd:cd18040 68 KSVDV---------VAELLLKVPGLkiLRVYSEQIETTEYP------------------IPNEPRHPNKKSERESKpNSE 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 965 VQAVAAHFPFHKyfsnAPQPvfkgrsYEEEMdiaegcyrhikKIFTQLEEFRAFELLRSGLDRSKYLLVKEAK------- 1037
Cdd:cd18040 121 LSSITLHHRIRQ----PSNP------HSQQI-----------KAFEARFERTQEKITEEDIKTYKILIWEARFeeletvd 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1038 IIAMTCTHAALKRhdlVELGFKYDNILMEEAAQILEIETFIPLLlqnpedGYSRLKRWIMIGDHHQLPPVIKNMAFQKYS 1117
Cdd:cd18040 180 VILCTCSEAASQK---MRTHANVKQCIVDECGMCTEPESLIPIV------SAPRAEQVVLIGDHKQLRPVVQNKEAQKLG 250
|
330
....*....|
gi 1811574662 1118 nMEQSLFTRF 1127
Cdd:cd18040 251 -LGRSLFERY 259
|
|
| DEXXQc_Upf1-like |
cd17934 |
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ... |
1036-1142 |
1.30e-11 |
|
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438708 [Multi-domain] Cd Length: 121 Bit Score: 63.02 E-value: 1.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1036 AKIIAMTCTHAALKRHDLVelgfkydniLMEEAAQILEIETFIPLLlqnpedgysRLKRWIMIGDHHQLPPVIKNMAFQK 1115
Cdd:cd17934 30 KRVLVTAQSNVAVDNVDVV---------IIDEASQITEPELLIALI---------RAKKVVLVGDPKQLPPVVQEDHAAL 91
|
90 100 110
....*....|....*....|....*....|
gi 1811574662 1116 Y---SNMEQSLFTRFVRLGVPTIDLDAQGR 1142
Cdd:cd17934 92 LglsFILSLLLLFRLLLPGSPKVMLDTQYR 121
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
1227-1307 |
5.26e-11 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 60.14 E-value: 5.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1227 RISILTTYNGQKHLIRDVInQRCAGNPFFSQPNKVTTVDRFQGQQNDYIILSLVRTkavgHLRDVRRLVVAMSRARLGLY 1306
Cdd:cd18786 12 KGVVLTPYHRDRAYLNQYL-QGLSLDEFDLQLVGAITIDSSQGLTFDVVTLYLPTA----NSLTPRRLYVALTRARKRLV 86
|
.
gi 1811574662 1307 I 1307
Cdd:cd18786 87 I 87
|
|
| DEXXQc_SMUBP2 |
cd18044 |
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, ... |
808-1135 |
3.09e-10 |
|
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, or IGHMBP2) is a 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. It is a DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence (5'-GGGCT-3') related to the immunoglobulin mu chain switch region. The IGHMBP2 gene is responsible for Charcot-Marie-Tooth disease (CMT) type 2S and spinal muscular atrophy with respiratory distress type 1 (SMARD1). It is also thought to play a role in frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) and major depressive disorder (MDD). SMUBP2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350802 [Multi-domain] Cd Length: 191 Bit Score: 61.09 E-value: 3.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 808 PTQIEAIR-AGMQPGLTMVVGPPGTGKTDVAVQIISNLYHnfPEQRTLIVTHSNQALNQLFEKIMALDIDerhLLRLGHG 886
Cdd:cd18044 4 DSQKEAVKfALSQKDVALIHGPPGTGKTTTVVEIILQAVK--RGEKVLACAPSNIAVDNLVERLVALKVK---VVRIGHP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 887 eeeletekdfsrygrvnyvlARRLELLrevgrLQESLDVpgdvsytcetaghfylyqvisrweeymskvkpkqgktvevq 966
Cdd:cd18044 79 --------------------ARLLESV-----LDHSLDA----------------------------------------- 92
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 967 avaahfpfhkyfsnapqpvfkgrsyeeemdiaegcyrhikkiftqleefrafellrsgldrskyllVKEAKIIAMTCTHA 1046
Cdd:cd18044 93 ------------------------------------------------------------------LVAAQVVLATNTGA 106
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1047 AlkrHDLVELGFKYDNILMEEAAQILEIETFIPLLlqnpedgysRLKRWIMIGDHHQLPPVIKNMAFQKYsNMEQSLFTR 1126
Cdd:cd18044 107 G---SRQLLPNELFDVVVIDEAAQALEASCWIPLL---------KARRCILAGDHKQLPPTILSDKAARG-GLGVTLFER 173
|
....*....
gi 1811574662 1127 FVRLGVPTI 1135
Cdd:cd18044 174 LVNLYGESV 182
|
|
| DEXXQc_DNA2 |
cd18041 |
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses ... |
1005-1127 |
5.32e-10 |
|
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5-3 helicase, and endonuclease activities, and is involved in DNA replication and DNA repair in the nucleus and mitochondrion. It is involved in Okazaki fragment processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. It is also involved in 5-end resection of DNA during double-strand break (DSB) repair; it is recruited by BLM and mediates the cleavage of 5-ssDNA, while the 3-ssDNA cleavage is prevented by the presence of RPA. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350799 [Multi-domain] Cd Length: 203 Bit Score: 60.71 E-value: 5.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1005 IKKIFTQLEEFRAFELLRSGLDRSKY-LLVKEAKIIAMTC---THAALKRHdlvelgfKYDNILMEEAAQILEIETFIPL 1080
Cdd:cd18041 78 LKKIHPDVQEFTLEAILKSCKSVEELeSKYESVSVVATTClgiNHPIFRRR-------TFDYCIVDEASQITLPICLGPL 150
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1811574662 1081 LLQnpedgysrlKRWIMIGDHHQLPPVIKNMAFQKySNMEQSLFTRF 1127
Cdd:cd18041 151 RLA---------KKFVLVGDHYQLPPLVKSREARE-LGMDESLFKRL 187
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
799-919 |
6.33e-07 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 51.72 E-value: 6.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 799 PKRNTIQFTPTQIEAIRAGMQ-PGLTMVVGPPGTGKTDVAVQIISNLYHNFPEQRTLIVTHSNQALNQLFEKIMAL--DI 875
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSgLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLgpSL 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1811574662 876 DERHLLRLGhGEEELETEKDFSR---------YGRVNYVLARRLELLREVGRL 919
Cdd:smart00487 82 GLKVVGLYG-GDSKREQLRKLESgktdilvttPGRLLDLLENDKLSLSNVDLV 133
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
808-899 |
7.33e-07 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 50.00 E-value: 7.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 808 PTQIEAIRAGMQ-----PGltMVVGPPGTGKTDVAVQIISNLYhnfpEQRTLIVTHSNQALNQLFEKIMALDIDeRHLLR 882
Cdd:cd17926 3 PYQEEALEAWLAhknnrRG--ILVLPTGSGKTLTALALIAYLK----ELRTLIVVPTDALLDQWKERFEDFLGD-SSIGL 75
|
90
....*....|....*....
gi 1811574662 883 LGHGEEELETEK--DFSRY 899
Cdd:cd17926 76 IGGGKKKDFDDAnvVVATY 94
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
810-870 |
3.40e-06 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 51.56 E-value: 3.40e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1811574662 810 QIEAIRA-------GMQPGLtmVVGPPGTGKTDVAVQIISNLYHNfpeQRTLIVTHSNQALNQLFEKI 870
Cdd:COG1061 85 QQEALEAllaalerGGGRGL--VVAPTGTGKTVLALALAAELLRG---KRVLVLVPRRELLEQWAEEL 147
|
|
| DEXXQc_SF1 |
cd18043 |
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are ... |
808-887 |
4.19e-06 |
|
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along with the concomitant unwinding of DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination, and repair as well as many aspects of RNA metabolism. Superfamily 1 helicases are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350801 [Multi-domain] Cd Length: 127 Bit Score: 47.58 E-value: 4.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 808 PTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNLYHNfpEQRTLIVTHSNQALNQLFEKIMALDIDE-RHLLRLGHG 886
Cdd:cd18043 2 SSQEAAIISARNGKNVVIQGPPGTGKSQTIANIIANALAR--GKRVLFVSEKKAALDVVRFPCWIMSPLSvSQYLPLNRN 79
|
.
gi 1811574662 887 E 887
Cdd:cd18043 80 L 80
|
|
| DEXXQc_Upf1-like |
cd17934 |
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ... |
822-866 |
8.78e-06 |
|
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438708 [Multi-domain] Cd Length: 121 Bit Score: 46.46 E-value: 8.78e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1811574662 822 LTMVVGPPGTGKTDVAVQIISNLYHNFPEQRTLIVTHSNQALNQL 866
Cdd:cd17934 1 ISLIQGPPGTGKTTTIAAIVLQLLKGLRGKRVLVTAQSNVAVDNV 45
|
|
| DEXXQc_HELZ |
cd18077 |
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that ... |
1033-1126 |
3.85e-05 |
|
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. HELZ is a member of the family I class of RNA helicases of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350835 [Multi-domain] Cd Length: 226 Bit Score: 46.71 E-value: 3.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1033 VKEAKIIAMT-CTHAALKRHDLVELGFKYdnILMEEAAQILEIETFIPLLLQNPEdgysrlKRWIMIGDHHQLPPVIKNm 1111
Cdd:cd18077 121 VMRHRVVVVTlSTSQYLCQLDLEPGFFTH--ILLDEAAQAMECEAIMPLALATKS------TRIVLAGDHMQLSPEVYS- 191
|
90
....*....|....*
gi 1811574662 1112 AFQKYSNMEQSLFTR 1126
Cdd:cd18077 192 EFARERNLHISLLER 206
|
|
| DEXXQc_HELZ2-N |
cd18076 |
N-terminal DEXXQ-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
1026-1126 |
1.99e-04 |
|
N-terminal DEXXQ-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB, and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350834 [Multi-domain] Cd Length: 230 Bit Score: 44.50 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 1026 DRSKYLLVKEAKI----IAMTCThaALKRHDLVELGFkYDNILMEEAAQILEIETFIPLLLQNPEdgysrlKRWIMIGDH 1101
Cdd:cd18076 112 DRQCFRLPTRDELdfhnIVITTT--AMAFNLHVLSGF-FTHIFIDEAAQMLECEALIPLSYAGPK------TRVVLAGDH 182
|
90 100
....*....|....*....|....*
gi 1811574662 1102 HQLPPviKNMAFQKYSNMEQSLFTR 1126
Cdd:cd18076 183 MQMTP--KLFSVADYNRANHTLLNR 205
|
|
| UvrD_C_2 |
pfam13538 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
1261-1307 |
2.01e-04 |
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UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 463913 [Multi-domain] Cd Length: 52 Bit Score: 40.25 E-value: 2.01e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1811574662 1261 VTTVDRFQGQQNDYIILSLVRTKAVGHLRDVRRLV-VAMSRARLGLYI 1307
Cdd:pfam13538 4 ALTVHKAQGSEFPAVFLVDPDLTAHYHSMLRRRLLyTAVTRARKKLVL 51
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| DEXXQc_Mov10L1 |
cd18078 |
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds ... |
827-940 |
2.13e-04 |
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DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. Mov10L1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350836 [Multi-domain] Cd Length: 230 Bit Score: 44.28 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 827 GPPGTGKTDVAVQIISNLYHNFPEQRTLIVTHSNQALNQLFEKIMaldidERHLLRLGhgeeeletekDFSRYGRVNYVL 906
Cdd:cd18078 27 GPPGTGKTVTIIEAILQVVYNLPRSRILVCAPSNSAADLVTSRLH-----ESKVLKPG----------DMVRLNAVNRFE 91
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90 100 110
....*....|....*....|....*....|....*..
gi 1811574662 907 ARRLELLREVGRLQESLDVPGD---VSYTCETAGHFY 940
Cdd:cd18078 92 STVIDARKLYCRLGEDLSKASRhriVISTCSTAGLLY 128
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| DEXHc_RE_I_III_res |
cd18032 |
DEXH-box helicase domain of type III restriction enzyme res subunit; Members of this model ... |
810-868 |
3.67e-04 |
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DEXH-box helicase domain of type III restriction enzyme res subunit; Members of this model includes both type I and type III restriction enzymes. Both are hetero-oligomeric proteins. Type I REs are encoded by three closely linked genes: a specificity subunit (HsdS or S) for recognizing a DNA sequence, a methylation subunit (HsdM or M) for methylating the recognized target bases, and a restriction subunit (HsdR or R) for the translocation and random cleavage of non-methylated DNA. They show diverse catalytic activities, including methyltransferase (MTase), ATP hydrolase (ATPase), DNA translocation and restriction activities. These enzymes cut at a site that differs, and is a random distance (at least 1000 bp) away, from their recognition site. Cleavage at these random sites follows a process of DNA translocation, which shows that these enzymes are also molecular motors. The recognition site is asymmetrical and is composed of two specific portions: one containing 3-4 nucleotides, and another containing 4-5 nucleotides, separated by a non-specific spacer of about 6-8 nucleotides. Type III enzymes are composed of two subunits, Res and Mod. The Mod subunit recognizes the DNA sequence specific for the system and is a modification methyltransferase; as such, it is functionally equivalent to the M and S subunits of type I restriction endonucleases. Res is required for restriction, although it has no enzymatic activity on its own. Type III enzymes recognize short 5-6 bp-long asymmetric DNA sequences and cleave 25-27 bp downstream to leave short, single-stranded 5' protrusions. They require the presence of two inversely oriented unmethylated recognition sites for restriction to occur. These enzymes methylate only one strand of the DNA, at the N-6 position of adenosyl residues, so newly replicated DNA will have only one strand methylated, which is sufficient to protect against restriction. Both type I and type III REs are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350790 [Multi-domain] Cd Length: 163 Bit Score: 42.55 E-value: 3.67e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1811574662 810 QIEAIRA---GMQPGLT--MVVGPPGTGKTDVAVQIISNLYHNFPEQRTLIVTHSN----QALNQLFE 868
Cdd:cd18032 5 QQEAIEAleeAREKGQRraLLVMATGTGKTYTAAFLIKRLLEANRKKRILFLAHREelleQAERSFKE 72
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| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
807-870 |
8.87e-04 |
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DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 42.12 E-value: 8.87e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1811574662 807 TPTQIEAIRAGMQPGLtmVVGPPGTGKTDVAVQIISNL--YHNFPEQRTLIVTHSNQALNQLFEKI 870
Cdd:cd17932 1 NPEQREAVTHPDGPLL--VLAGAGSGKTRVLTHRIAYLilEGGVPPERILAVTFTNKAAKEMRERL 64
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| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
807-921 |
7.92e-03 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 38.76 E-value: 7.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1811574662 807 TPTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQ-IISNLYHNFPEQRTLIVTH----SNQALNQlFEKIMALDIDERHLL 881
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLpALEALDKLDNGPQALVLAPtrelAEQIYEE-LKKLGKGLGLKVASL 79
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90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1811574662 882 RLGHgeeelETEKDFSRYGRVNYVLA---RRLELLREVGRLQE 921
Cdd:pfam00270 80 LGGD-----SRKEQLEKLKGPDILVGtpgRLLDLLQERKLLKN 117
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