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Conserved domains on  [gi|1720370276|ref|XP_030102365|]
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spermatogenesis-associated protein 7 homolog isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HSD3 super family cl21103
Spermatogenesis-associated protein 7, or HSD3; Spermatogenesis-associated protein HSD3 also ...
1-302 2.52e-170

Spermatogenesis-associated protein 7, or HSD3; Spermatogenesis-associated protein HSD3 also goes by the name of spermatogenesis-associated protein 7 or SPAT7. The family carries a single transmembrane domain. It functions in several tissues, and is expressed in the developing and mature mouse retina; it is expressed in multiple retinal layers in the adult mouse retina. Mutations lead to LCA disease, or Leber congenital amaurosis, which results in a number of retinal dystrophies. The disease- phenotype is characterized by severe visual loss at birth, nystagmus, a variety of fundus changes, and minimal or absent recordable responses on the electroretinogram (ERG).


The actual alignment was detected with superfamily member pfam15244:

Pssm-ID: 464584  Cd Length: 414  Bit Score: 485.46  E-value: 2.52e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370276   1 MQTNSKMNSKFFVNSLQKPSGEPQDQ-DVFIEEMTRYPSFSKSLIPSSEGLHLSLPESSKMLMSGTQKHASTSPS----- 74
Cdd:pfam15244  99 SQANSKNNSKSLSNTLQKPSGEPQDEdDVLIEEMNEFPSFSKSRVPSSERLHLSLPKSSRSLTNGTEKNSSSSLSsmdst 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370276  75 ----RHSGCGHGCDRRPR----SAHQFQVALAKTPSGDLLEKHSDLFSNKQSPFTPRTLKTEAKSFLSQYRYYTPAKRRK 146
Cdd:pfam15244 179 ssrrRKSGSSSTSSSGPRktfpSSHRFQLVISKAPSGDLLDKHSELFTNKQLPFTPRTLKTEAKSFLSQYRYYTPARRKK 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370276 147 DFSDQRMEAETQTELSSFNSELGTAEKTSSKDSEVNINQVPNYTRNGAEDKIAPLPSQGQNLAWDSIQDGILQQSSERAS 226
Cdd:pfam15244 259 DFTDQRIEAETQTELSSFKSDFGTAETKNFTDSEVNIKQASNCVTYGTKEKIAPLPSQGHGLTWDEVKDGALQCSSSRAV 338
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720370276 227 CKLSTEFSPDSKIYSDEEELLYLSFMENVTDEILKLGLFSNRFLERLFERHIKKNKHHLEEGKMRYLLHGLKVDLG 302
Cdd:pfam15244 339 CPYSLQPPAMRKIYAEEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHHLEEEKMRHLLHVLKVDLG 414
 
Name Accession Description Interval E-value
HSD3 pfam15244
Spermatogenesis-associated protein 7, or HSD3; Spermatogenesis-associated protein HSD3 also ...
1-302 2.52e-170

Spermatogenesis-associated protein 7, or HSD3; Spermatogenesis-associated protein HSD3 also goes by the name of spermatogenesis-associated protein 7 or SPAT7. The family carries a single transmembrane domain. It functions in several tissues, and is expressed in the developing and mature mouse retina; it is expressed in multiple retinal layers in the adult mouse retina. Mutations lead to LCA disease, or Leber congenital amaurosis, which results in a number of retinal dystrophies. The disease- phenotype is characterized by severe visual loss at birth, nystagmus, a variety of fundus changes, and minimal or absent recordable responses on the electroretinogram (ERG).


Pssm-ID: 464584  Cd Length: 414  Bit Score: 485.46  E-value: 2.52e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370276   1 MQTNSKMNSKFFVNSLQKPSGEPQDQ-DVFIEEMTRYPSFSKSLIPSSEGLHLSLPESSKMLMSGTQKHASTSPS----- 74
Cdd:pfam15244  99 SQANSKNNSKSLSNTLQKPSGEPQDEdDVLIEEMNEFPSFSKSRVPSSERLHLSLPKSSRSLTNGTEKNSSSSLSsmdst 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370276  75 ----RHSGCGHGCDRRPR----SAHQFQVALAKTPSGDLLEKHSDLFSNKQSPFTPRTLKTEAKSFLSQYRYYTPAKRRK 146
Cdd:pfam15244 179 ssrrRKSGSSSTSSSGPRktfpSSHRFQLVISKAPSGDLLDKHSELFTNKQLPFTPRTLKTEAKSFLSQYRYYTPARRKK 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370276 147 DFSDQRMEAETQTELSSFNSELGTAEKTSSKDSEVNINQVPNYTRNGAEDKIAPLPSQGQNLAWDSIQDGILQQSSERAS 226
Cdd:pfam15244 259 DFTDQRIEAETQTELSSFKSDFGTAETKNFTDSEVNIKQASNCVTYGTKEKIAPLPSQGHGLTWDEVKDGALQCSSSRAV 338
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720370276 227 CKLSTEFSPDSKIYSDEEELLYLSFMENVTDEILKLGLFSNRFLERLFERHIKKNKHHLEEGKMRYLLHGLKVDLG 302
Cdd:pfam15244 339 CPYSLQPPAMRKIYAEEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHHLEEEKMRHLLHVLKVDLG 414
 
Name Accession Description Interval E-value
HSD3 pfam15244
Spermatogenesis-associated protein 7, or HSD3; Spermatogenesis-associated protein HSD3 also ...
1-302 2.52e-170

Spermatogenesis-associated protein 7, or HSD3; Spermatogenesis-associated protein HSD3 also goes by the name of spermatogenesis-associated protein 7 or SPAT7. The family carries a single transmembrane domain. It functions in several tissues, and is expressed in the developing and mature mouse retina; it is expressed in multiple retinal layers in the adult mouse retina. Mutations lead to LCA disease, or Leber congenital amaurosis, which results in a number of retinal dystrophies. The disease- phenotype is characterized by severe visual loss at birth, nystagmus, a variety of fundus changes, and minimal or absent recordable responses on the electroretinogram (ERG).


Pssm-ID: 464584  Cd Length: 414  Bit Score: 485.46  E-value: 2.52e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370276   1 MQTNSKMNSKFFVNSLQKPSGEPQDQ-DVFIEEMTRYPSFSKSLIPSSEGLHLSLPESSKMLMSGTQKHASTSPS----- 74
Cdd:pfam15244  99 SQANSKNNSKSLSNTLQKPSGEPQDEdDVLIEEMNEFPSFSKSRVPSSERLHLSLPKSSRSLTNGTEKNSSSSLSsmdst 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370276  75 ----RHSGCGHGCDRRPR----SAHQFQVALAKTPSGDLLEKHSDLFSNKQSPFTPRTLKTEAKSFLSQYRYYTPAKRRK 146
Cdd:pfam15244 179 ssrrRKSGSSSTSSSGPRktfpSSHRFQLVISKAPSGDLLDKHSELFTNKQLPFTPRTLKTEAKSFLSQYRYYTPARRKK 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720370276 147 DFSDQRMEAETQTELSSFNSELGTAEKTSSKDSEVNINQVPNYTRNGAEDKIAPLPSQGQNLAWDSIQDGILQQSSERAS 226
Cdd:pfam15244 259 DFTDQRIEAETQTELSSFKSDFGTAETKNFTDSEVNIKQASNCVTYGTKEKIAPLPSQGHGLTWDEVKDGALQCSSSRAV 338
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720370276 227 CKLSTEFSPDSKIYSDEEELLYLSFMENVTDEILKLGLFSNRFLERLFERHIKKNKHHLEEGKMRYLLHGLKVDLG 302
Cdd:pfam15244 339 CPYSLQPPAMRKIYAEEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHHLEEEKMRHLLHVLKVDLG 414
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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