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Conserved domains on  [gi|1720426074|ref|XP_030099078|]
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ankyrin repeat domain-containing protein 10 isoform X3 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  33435370|17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-105 1.66e-22

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.41  E-value: 1.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   2 QLVRAGASLNVsTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRN 81
Cdd:COG0666   105 LLLEAGADVNA-RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD 183

                          90       100
                  ....*....|....*....|....
gi 1720426074  82 ASGLTAADIAQTQGFQECTQFLLS 105
Cdd:COG0666   184 NDGETPLHLAAENGHLEIVKLLLE 207
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-105 1.66e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.41  E-value: 1.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   2 QLVRAGASLNVsTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRN 81
Cdd:COG0666   105 LLLEAGADVNA-RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD 183

                          90       100
                  ....*....|....*....|....
gi 1720426074  82 ASGLTAADIAQTQGFQECTQFLLS 105
Cdd:COG0666   184 NDGETPLHLAAENGHLEIVKLLLE 207
Ank_2 pfam12796
Ankyrin repeats (3 copies);
23-105 1.16e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 1.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074  23 HIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVgsgAHTDLRNA-SGLTAADIAQTQGFQECTQ 101
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL---EHADVNLKdNGRTALHYAARSGHLEIVK 78


                  ....
gi 1720426074 102 FLLS 105
Cdd:pfam12796  79 LLLE 82
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 3-138 1.90e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.27  E-value: 1.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   3 LVRAGASLNVSTtRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRNA 82
Cdd:PHA02874  110 ILDCGIDVNIKD-AELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720426074  83 SGLTAADIAQTQGFQECTQFLLSLQNHQMSRfCHNGtlsgghesILPTHVSLGTNR 138
Cdd:PHA02874  189 NGESPLHNAAEYGDYACIKLLIDHGNHIMNK-CKNG--------FTPLHNAIIHNR 235
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 20-46 1.65e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.65e-03
                           10        20
                   ....*....|....*....|....*..
gi 1720426074   20 TPAHIAAFGGHPQCLVWLIQAGANINK 46
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-105 1.66e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.41  E-value: 1.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   2 QLVRAGASLNVsTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRN 81
Cdd:COG0666   105 LLLEAGADVNA-RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD 183

                          90       100
                  ....*....|....*....|....
gi 1720426074  82 ASGLTAADIAQTQGFQECTQFLLS 105
Cdd:COG0666   184 NDGETPLHLAAENGHLEIVKLLLE 207
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-104 4.33e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 94.25  E-value: 4.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   3 LVRAGASLNVsTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRNA 82
Cdd:COG0666   139 LLEAGADVNA-QDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                          90       100
                  ....*....|....*....|..
gi 1720426074  83 SGLTAADIAQTQGFQECTQFLL 104
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLL 239
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-105 3.58e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 77.69  E-value: 3.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   1 MQLVRAGASLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLR 80
Cdd:COG0666    70 ALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQ 149

                          90       100
                  ....*....|....*....|....*
gi 1720426074  81 NASGLTAADIAQTQGFQECTQFLLS 105
Cdd:COG0666   150 DNDGNTPLHLAAANGNLEIVKLLLE 174
Ank_2 pfam12796
Ankyrin repeats (3 copies);
23-105 1.16e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 1.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074  23 HIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVgsgAHTDLRNA-SGLTAADIAQTQGFQECTQ 101
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL---EHADVNLKdNGRTALHYAARSGHLEIVK 78


                  ....
gi 1720426074 102 FLLS 105
Cdd:pfam12796  79 LLLE 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-104 4.63e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.52  E-value: 4.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   3 LVRAGASLNVsTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRNA 82
Cdd:COG0666   172 LLEAGADVNA-RDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDK 250

                          90       100
                  ....*....|....*....|..
gi 1720426074  83 SGLTAADIAQTQGFQECTQFLL 104
Cdd:COG0666   251 DGLTALLLAAAAGAALIVKLLL 272
Ank_2 pfam12796
Ankyrin repeats (3 copies);
2-81 3.81e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.97  E-value: 3.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   2 QLVRAGASLNVsTTRYAQTPAHIAAFGGHPQCLVWLIQaGANINKpDCEGETPIHKAARSGSLECITALVGSGAHTDLRN 81
Cdd:pfam12796  15 LLLENGADANL-QDKNGRTALHLAAKNGHLEIVKLLLE-HADVNL-KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
20-71 6.86e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.90  E-value: 6.86e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720426074  20 TPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALV 71
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-105 9.78e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.73  E-value: 9.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   6 AGASLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRNASGL 85
Cdd:COG0666    42 LALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGE 121

                          90       100
                  ....*....|....*....|
gi 1720426074  86 TAADIAQTQGFQECTQFLLS 105
Cdd:COG0666   122 TPLHLAAYNGNLEIVKLLLE 141
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 3-138 1.90e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.27  E-value: 1.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   3 LVRAGASLNVSTtRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRNA 82
Cdd:PHA02874  110 ILDCGIDVNIKD-AELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720426074  83 SGLTAADIAQTQGFQECTQFLLSLQNHQMSRfCHNGtlsgghesILPTHVSLGTNR 138
Cdd:PHA02874  189 NGESPLHNAAEYGDYACIKLLIDHGNHIMNK-CKNG--------FTPLHNAIIHNR 235
Ank_5 pfam13857
Ankyrin repeats (many copies);
37-91 3.25e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 3.25e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720426074  37 LIQAG-ANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRNASGLTAADIA 91
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 2-104 1.13e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.25  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   2 QLVRAGASLNVSTTRyAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPI--------HK---------------- 57
Cdd:PLN03192  543 ELLKAKLDPDIGDSK-GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALwnaisakhHKifrilyhfasisdpha 621

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720426074  58 -------AARSGSLECITALVGSGAHTDLRNASGLTAADIAQTQGFQECTQFLL 104
Cdd:PLN03192  622 agdllctAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
Ank_4 pfam13637
Ankyrin repeats (many copies);
53-104 1.84e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.57  E-value: 1.84e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720426074  53 TPIHKAARSGSLECITALVGSGAHTDLRNASGLTAADIAQTQGFQECTQFLL 104
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 3-91 2.37e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.11  E-value: 2.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   3 LVRAGASLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRNA 82
Cdd:PHA02878  153 LLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDK 232


                  ....*....
gi 1720426074  83 SGLTAADIA 91
Cdd:PHA02878  233 CGNTPLHIS 241
Ank_2 pfam12796
Ankyrin repeats (3 copies);
55-118 1.23e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.18  E-value: 1.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720426074  55 IHKAARSGSLECITALVGSGAHTDLRNASGLTAADIAQTQGFQECTQFLLslqNHQMSRFCHNG 118
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL---EHADVNLKDNG 61
Ank_5 pfam13857
Ankyrin repeats (many copies);
3-58 1.54e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.95  E-value: 1.54e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720426074   3 LVRAGASLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKA 58
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-88 1.54e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.10  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   3 LVRAGASLNVsTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRNA 82
Cdd:COG0666   205 LLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283


                  ....*.
gi 1720426074  83 SGLTAA 88
Cdd:COG0666   284 DLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-90 5.40e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.63  E-value: 5.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   3 LVRAGASLNVsTTRYAQTPAHI-AAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSL--ECITALVGSGAHTDL 79
Cdd:PHA03095   69 LLEAGADVNA-PERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSGFNInpKVIRLLLRKGADVNA 147

                          90
                  ....*....|.
gi 1720426074  80 RNASGLTAADI 90
Cdd:PHA03095  148 LDLYGMTPLAV 158
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 37-105 1.13e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.73  E-value: 1.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720426074  37 LIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRNASGLTAADIAQTQGFQECTQFLLS 105
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 37-91 4.38e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.96  E-value: 4.38e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720426074  37 LIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRNASGLTAADIA 91
Cdd:PHA03100  178 LLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA 232
PHA03095 PHA03095
ankyrin-like protein; Provisional
 2-55 1.01e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.78  E-value: 1.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720426074   2 QLVRAGASLNvSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPI 55
Cdd:PHA03095  242 PLLIAGISIN-ARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 3-72 1.43e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 1.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074   3 LVRAGASLNvSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVG 72
Cdd:PTZ00322  101 LLTGGADPN-CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 3-75 1.46e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 1.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720426074   3 LVRAGASLNVSTTRYaQTPAHIAA-FGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGA 75
Cdd:PHA02876  327 LIMLGADVNAADRLY-ITPLHQAStLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGA 399
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 20-46 1.65e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.65e-03
                           10        20
                   ....*....|....*....|....*..
gi 1720426074   20 TPAHIAAFGGHPQCLVWLIQAGANINK 46
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 19-48 3.00e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 3.00e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1720426074  19 QTPAHIAA-FGGHPQCLVWLIQAGANINKPD 48
Cdd:pfam00023   3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 17-75 5.46e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 38.49  E-value: 5.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720426074  17 YAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGA 75
Cdd:PHA03100  191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 20-104 8.57e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 37.66  E-value: 8.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720426074  20 TPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECITALVGSGAHTDLRNASGLTAADIAQTQGFQEC 99
Cdd:PHA02875  104 TPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAI 183


                  ....*
gi 1720426074 100 TQFLL 104
Cdd:PHA02875  184 CKMLL 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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