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Conserved domains on  [gi|1039770408|ref|XP_017176133|]
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citron Rho-interacting kinase isoform X26 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1187-1483 1.05e-78

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


:

Pssm-ID: 214481  Cd Length: 302  Bit Score: 262.67  E-value: 1.05e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  1187 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1259
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  1260 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1333
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  1334 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1409
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039770408  1410 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1483
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 938-993 4.00e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


:

Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 4.00e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770408  938 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 993
Cdd:cd20814      1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 202-792 5.50e-24

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 110.03  E-value: 5.50e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  202 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLE 281
Cdd:COG1196    209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELEL 283

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  282 VHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLA 361
Cdd:COG1196    284 EEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEA 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  362 ANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsdksRLLELETRLREVSLEHEEQKLE 441
Cdd:COG1196    364 EEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEE-----------ALLERLERLEEELEELEEALAE 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  442 LKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeEEIQALTAHRDEIQRKFDALRnsctvitdLEE 521
Cdd:COG1196    433 LEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL-----------EEAALLEAALAELLEELAEAA--------ARL 493

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  522 QLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTT---- 597
Cdd:COG1196    494 LLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAkagr 573

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  598 CTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKA 677
Cdd:COG1196    574 ATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEG 653

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  678 EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQ 757
Cdd:COG1196    654 EGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAE 733

                          570       580       590
                   ....*....|....*....|....*....|....*
gi 1039770408  758 EALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 792
Cdd:COG1196    734 REELLEELLEEEELLEEEALEELPEPPDLEELERE 768
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1023-1142 5.11e-08

PH domain; PH stands for pleckstrin homology.


:

Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 52.56  E-value: 5.11e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1023 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1102
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039770408 1103 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1142
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
SMC_N super family cl47134
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 2-325 2.04e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


The actual alignment was detected with superfamily member TIGR02169:

Pssm-ID: 481474 [Multi-domain]  Cd Length: 1164  Bit Score: 52.76  E-value: 2.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKR---SLEQARMEVSQEDDKALQ 78
Cdd:TIGR02169  686 LKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEdlsSLEQEIENVKSELKELEA 765

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   79 LLHDIREQSRKLQE----IKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELrESRLAAEEFKRKanECQHKLMKV 154
Cdd:TIGR02169  766 RIEELEEDLHKLEEalndLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKL-NRLTLEKEYLEK--EIQELQEQR 842

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  155 VSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPE--VGEYSKLEKINAEQQLKIQELQEKLEKAvKASTEATELLQNI 232
Cdd:TIGR02169  843 IDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRdlESRLGDLKKERDELEAQLRELERKIEEL-EAQIEKKRKRLSE 921

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  233 RQAK-ERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLE-VHLKQKEQHYEEKIKVLDNQIKKD--LAD 308
Cdd:TIGR02169  922 LKAKlEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRALEpVNMLAIQEYEEVLKRLDELKEKRAklEEE 1001

                          330
                   ....*....|....*..
gi 1039770408  309 KESLENMMQRHEEEAHE 325
Cdd:TIGR02169 1002 RKAILERIEEYEKKKRE 1018
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 1499-1590 1.26e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.07  E-value: 1.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1499 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1562
Cdd:PTZ00449   527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606

                           90       100       110
                   ....*....|....*....|....*....|
gi 1039770408 1563 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1590
Cdd:PTZ00449   607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
 
Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1187-1483 1.05e-78

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 262.67  E-value: 1.05e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  1187 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1259
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  1260 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1333
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  1334 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1409
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039770408  1410 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1483
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 1195-1447 3.45e-68

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 230.60  E-value: 3.45e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1195 SDQVVLVGTEEGLYALNV-LKNSLTHIPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDVSP 1273
Cdd:pfam00780    1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1274 NIFEAVKGCHLFAAGKIENSLCICAAMPSKVVILRYNDNLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1351
Cdd:pfam00780   77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1352 QYTLDEFLdkndhsLAPAVFASSSNSFPVSIVQANsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1431
Cdd:pfam00780  157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226

                          250
                   ....*....|....*.
gi 1039770408 1432 YLFVTHFNSLEVIEIQ 1447
Cdd:pfam00780  227 YLLAFHDNFIEIRDVE 242
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 938-993 4.00e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 4.00e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770408  938 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 993
Cdd:cd20814      1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 202-792 5.50e-24

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 110.03  E-value: 5.50e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  202 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLE 281
Cdd:COG1196    209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELEL 283

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  282 VHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLA 361
Cdd:COG1196    284 EEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEA 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  362 ANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsdksRLLELETRLREVSLEHEEQKLE 441
Cdd:COG1196    364 EEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEE-----------ALLERLERLEEELEELEEALAE 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  442 LKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeEEIQALTAHRDEIQRKFDALRnsctvitdLEE 521
Cdd:COG1196    433 LEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL-----------EEAALLEAALAELLEELAEAA--------ARL 493

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  522 QLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTT---- 597
Cdd:COG1196    494 LLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAkagr 573

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  598 CTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKA 677
Cdd:COG1196    574 ATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEG 653

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  678 EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQ 757
Cdd:COG1196    654 EGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAE 733

                          570       580       590
                   ....*....|....*....|....*....|....*
gi 1039770408  758 EALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 792
Cdd:COG1196    734 REELLEELLEEEELLEEEALEELPEPPDLEELERE 768
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 72-859 5.36e-22

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 103.98  E-value: 5.36e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   72 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 137
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  138 EEFKRKANECQHKLmkvvshpprgdsggtalddlhkmqghagltsakdqgkpevgeYSKLEKINAEQQlKIQELQEKLEK 217
Cdd:TIGR02168  277 SELEEEIEELQKEL------------------------------------------YALANEISRLEQ-QKQILRERLAN 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  218 AVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgikkklVEAEELEEKHREAQVSAQHLEVHLKQKEQHYE----- 292
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDELAEELAELEEKLEELK------EELESLEAELEELEAELEELESRLEELEEQLEtlrsk 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  293 -----EKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQK-----AMINAMDSKIRSLEQRIVELSEANKLAA 362
Cdd:TIGR02168  388 vaqleLQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAElkelqAELEELEEELEELQEELERLEEALEELR 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  363 NSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKiSHQDHSDKSRLLEL-------ETRLrEVSLEH 435
Cdd:TIGR02168  468 EELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKN-QSGLSGILGVLSELisvdegyEAAI-EAALGG 545

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  436 EEQKLELKRQLTELQL--SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC 513
Cdd:TIGR02168  546 RLQAVVVENLNAAKKAiaFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGV 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  514 TVITDLEEQLNQLTEDNAELNnqNFYLSKQLDEASG--------ANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSA 585
Cdd:TIGR02168  626 LVVDDLDNALELAKKLRPGYR--IVTLDGDLVRPGGvitggsakTNSSILERRREIEELEEKIEELEEKIAELEKALAEL 703

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  586 PDLQT-----MEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQR 660
Cdd:TIGR02168  704 RKELEeleeeLEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  661 ITESRQVVELAVKEHKA---EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAK 737
Cdd:TIGR02168  784 IEELEAQIEQLKEELKAlreALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  738 LQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIqvlySHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKK 817
Cdd:TIGR02168  864 LEELIEELESELEALLNERASLEEALALLRSELEELSEELREL----ESKRSELRRELEELREKLAQLELRLEGLEVRID 939

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|...
gi 1039770408  818 GLFSRRKEDPALPTQVPLQ-YNELKLALEKEKARCAELEEALQ 859
Cdd:TIGR02168  940 NLQERLSEEYSLTLEEAEAlENKIEDDEEEARRRLKRLENKIK 982
PTZ00121 PTZ00121
MAEBL; Provisional
 5-774 1.42e-17

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 89.82  E-value: 1.42e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVElKASETQRSllEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIR 84
Cdd:PTZ00121  1112 EEARKAEEAKKKAEDARKAEEARKAEDAR-KAEEARKA--EDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVR 1188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   85 --EQSRKLQEIKEQEYQAQVEEMRlmmnQLEEdlvsARRrsdlYESELR-ESRLAAEEFKRKANECQHklmkvvSHPPRG 161
Cdd:PTZ00121  1189 kaEELRKAEDARKAEAARKAEEER----KAEE----ARK----AEDAKKaEAVKKAEEAKKDAEEAKK------AEEERN 1250

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  162 DSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKI-------NAEQQLKIQELQEKLEKAVKASteatELLQNIRQ 234
Cdd:PTZ00121  1251 NEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKkkadeakKAEEKKKADEAKKKAEEAKKAD----EAKKKAEE 1326

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  235 AKERAERELEKLHNREDSSEGIKKklveaeELEEKHREAQVSAQHLEVHLKQKEqhyEEKIKVldNQIKKDLADKESLEN 314
Cdd:PTZ00121  1327 AKKKADAAKKKAEEAKKAAEAAKA------EAEAAADEAEAAEEKAEAAEKKKE---EAKKKA--DAAKKKAEEKKKADE 1395

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  315 MMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQEEMISELRQQKfylETQAG 394
Cdd:PTZ00121  1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKAD--EAKKKAEEAKKADEAKKKAEEAKKAEEAKKK---AEEAK 1470

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  395 KLEAQNRKLEE--QLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESqltalQAARAALEs 472
Cdd:PTZ00121  1471 KADEAKKKAEEakKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA-----DEAKKAEE- 1544

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  473 qLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvitdleEQLNQLTEDNAELNNQNFYLSKQLDEASGAND 552
Cdd:PTZ00121  1545 -KKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKA--------EEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA 1615

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  553 EIVQLRSEvdHLRREITEREMQLTSQKQaqlSAPDLQTMEALKTTctmLEEQVLDLEALNDELLEKERQWEAWRSVLGDE 632
Cdd:PTZ00121  1616 EEAKIKAE--ELKKAEEEKKKVEQLKKK---EAEEKKKAEELKKA---EEENKIKAAEEAKKAEEDKKKAEEAKKAEEDE 1687

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  633 KSQFECRVRELQRMLDTEkQSRARADQRITESRQVVElAVKEHKAEILALQQALKEQKLKAESLsdKLNDLEKK---HAM 709
Cdd:PTZ00121  1688 KKAAEALKKEAEEAKKAE-ELKKKEAEEKKKAEELKK-AEEENKIKAEEAKKEAEEDKKKAEEA--KKDEEEKKkiaHLK 1763

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039770408  710 LEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLE 774
Cdd:PTZ00121  1764 KEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEME 1828
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 22-877 7.47e-17

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 86.95  E-value: 7.47e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   22 EVEAVLSQKEVElkasetqRSLLEQDLATYItecssLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEyqaq 101
Cdd:pfam02463  143 KIEIIAMMKPER-------RLEIEEEAAGSR-----LKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQA---- 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  102 veemrlmmnqleedlvsarrrsdlyESELRESRLAAEEFKRKANECQHKLMKVVshpprgdsgGTALDDLHKMQGHAGLT 181
Cdd:pfam02463  207 -------------------------KKALEYYQLKEKLELEEEYLLYLDYLKLN---------EERIDLLQELLRDEQEE 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  182 SAKDQGKPEVGEySKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV 261
Cdd:pfam02463  253 IESSKQEIEKEE-EKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELK 331

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  262 ----EAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAmI 337
Cdd:pfam02463  332 kekeEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQL-L 410

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  338 NAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSD 417
Cdd:pfam02463  411 LELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLL 490

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  418 KSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQER---------ESQLTALQAARAALESQLRQAKTELEETTAEA 488
Cdd:pfam02463  491 SRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGrlgdlgvavENYKVAISTAVIVEVSATADEVEERQKLVRAL 570

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  489 EEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSkqldEASGANDEIVQLRSEVDHLRREI 568
Cdd:pfam02463  571 TELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAK----VVEGILKDTELTKLKESAKAKES 646

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  569 TEREMQLTSQKQAQLSapdLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLD 648
Cdd:pfam02463  647 GLRKGVSLEEGLAEKS---EVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELL 723

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  649 TEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL---ETER 725
Cdd:pfam02463  724 ADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLkaqEEEL 803

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  726 ELKQRLLEEQAKLQQQMDLQKNH---------------IFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVK 790
Cdd:pfam02463  804 RALEEELKEEAELLEEEQLLIEQeekikeeeleelaleLKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQK 883

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  791 -------MEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRI 863
Cdd:pfam02463  884 lkdelesKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNK 963

                          890
                   ....*....|....
gi 1039770408  864 ELRSAREEAAHRKA 877
Cdd:pfam02463  964 RLLLAKEELGKVNL 977
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 942-990 1.77e-10

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 57.48  E-value: 1.77e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1039770408   942 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 990
Cdd:smart00109    1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1195-1446 1.75e-09

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 62.99  E-value: 1.75e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1195 SDQVVLVGTEEGLYALNVLKNS--------LTHIPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1266
Cdd:COG5422    868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1267 aqpDVSPNIFEAVK-----GCHLFAAGKiENSLCICAAMPSKVVILRYNDN------LSKYCIRKEIETSEPCScIHFTN 1335
Cdd:COG5422    944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNKSgnlkkaLTIELSTELYVPSEPLS-VHFLK 1018

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1336 YSILIGTNKFYEI-DMKQYTLDEFLDKNDHSlaPAVFASSSNSFPVSIVQANSagqreEYLLCFHEFGVFVDSYGRRSRT 1414
Cdd:COG5422   1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1039770408 1415 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1446
Cdd:COG5422   1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1023-1142 5.11e-08

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 52.56  E-value: 5.11e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1023 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1102
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039770408 1103 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1142
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 1023-1142 1.83e-07

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 50.62  E-value: 1.83e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  1023 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1102
Cdd:smart00233    1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1039770408  1103 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1142
Cdd:smart00233   69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
C1_1 pfam00130
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ...
 937-992 1.92e-06

Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.


Pssm-ID: 395079  Cd Length: 53  Bit Score: 46.28  E-value: 1.92e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770408  937 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 992
Cdd:pfam00130    1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 2-325 2.04e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 52.76  E-value: 2.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKR---SLEQARMEVSQEDDKALQ 78
Cdd:TIGR02169  686 LKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEdlsSLEQEIENVKSELKELEA 765

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   79 LLHDIREQSRKLQE----IKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELrESRLAAEEFKRKanECQHKLMKV 154
Cdd:TIGR02169  766 RIEELEEDLHKLEEalndLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKL-NRLTLEKEYLEK--EIQELQEQR 842

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  155 VSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPE--VGEYSKLEKINAEQQLKIQELQEKLEKAvKASTEATELLQNI 232
Cdd:TIGR02169  843 IDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRdlESRLGDLKKERDELEAQLRELERKIEEL-EAQIEKKRKRLSE 921

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  233 RQAK-ERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLE-VHLKQKEQHYEEKIKVLDNQIKKD--LAD 308
Cdd:TIGR02169  922 LKAKlEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRALEpVNMLAIQEYEEVLKRLDELKEKRAklEEE 1001

                          330
                   ....*....|....*..
gi 1039770408  309 KESLENMMQRHEEEAHE 325
Cdd:TIGR02169 1002 RKAILERIEEYEKKKRE 1018
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1499-1590 1.26e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.07  E-value: 1.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1499 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1562
Cdd:PTZ00449   527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606

                           90       100       110
                   ....*....|....*....|....*....|
gi 1039770408 1563 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1590
Cdd:PTZ00449   607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 10-269 2.28e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 89
Cdd:COG4942     26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   90 LQE-IKEQEYQAQVEEMRLMMNQleEDLVSARRRSDLYESELRESRLAAEEFKRKANEcqhklmkvvshpprgdsggtal 168
Cdd:COG4942    106 LAElLRALYRLGRQPPLALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAE---------------------- 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  169 ddlhkmqghagLTSAKDQgkpevgeyskLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHN 248
Cdd:COG4942    162 -----------LAALRAE----------LEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQ 220

                          250       260
                   ....*....|....*....|.
gi 1039770408  249 REDSSEGIKKKLVEAEELEEK 269
Cdd:COG4942    221 EAEELEALIARLEAEAAAAAE 241
PH_ROCK cd01242
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ...
 1024-1069 5.83e-05

Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269948  Cd Length: 110  Bit Score: 43.88  E-value: 5.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1039770408 1024 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1069
Cdd:cd01242      2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 6-299 8.21e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 43.73  E-value: 8.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    6 EAMMEQEmTRLHRRVSEVEAVLSQKevelKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIRE 85
Cdd:pfam07888  143 QRVLERE-TELERMKERAKKAGAQR----KEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITT 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   86 QSRKLQEIKEQEyqAQVEEMRLMMNQLEEDLVSARRRSDLYESELREsrlaaeefkrkanecqhklmkvvshpprgdsgg 165
Cdd:pfam07888  218 LTQKLTTAHRKE--AENEALLEELRSLQERLNASERKVEGLGEELSS--------------------------------- 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  166 talddlhkmqghagLTSAKDQGKPEVGEySKLEKINAEQQLKIQELQEKLEKAvKASTEATELLQNIRQAKERAER---E 242
Cdd:pfam07888  263 --------------MAAQRDRTQAELHQ-ARLQAAQLTLQLADASLALREGRA-RWAQERETLQQSAEADKDRIEKlsaE 326

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770408  243 LEKLHNR--EDSSEGIKKKLVEAEE-------LEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD 299
Cdd:pfam07888  327 LQRLEERlqEERMEREKLEVELGREkdcnrvqLSESRRELQELKASLRVAQKEKEQLQAEKQELLE 392
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 492-611 2.11e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 41.97  E-value: 2.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  492 IQALTahrDEIQRKFDALRNSCT-VITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN--DEIVQLRSEVDHLRREI 568
Cdd:cd22656    119 IKALL---DDLLKEAKKYQDKAAkVVDKLTDFENQTEKDQTALETLEKALKDLLTDEGGAIarKEIKDLQKELEKLNEEY 195

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1039770408  569 TER---EMQLTSQKQAQLSApDLQTMEALKTTCTMLEEQVLDLEAL 611
Cdd:cd22656    196 AAKlkaKIDELKALIADDEA-KLAAALRLIADLTAADTDLDNLLAL 240
 
Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1187-1483 1.05e-78

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 262.67  E-value: 1.05e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  1187 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1259
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  1260 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1333
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  1334 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1409
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039770408  1410 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1483
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 1195-1447 3.45e-68

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 230.60  E-value: 3.45e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1195 SDQVVLVGTEEGLYALNV-LKNSLTHIPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDVSP 1273
Cdd:pfam00780    1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1274 NIFEAVKGCHLFAAGKIENSLCICAAMPSKVVILRYNDNLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1351
Cdd:pfam00780   77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1352 QYTLDEFLdkndhsLAPAVFASSSNSFPVSIVQANsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1431
Cdd:pfam00780  157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226

                          250
                   ....*....|....*.
gi 1039770408 1432 YLFVTHFNSLEVIEIQ 1447
Cdd:pfam00780  227 YLLAFHDNFIEIRDVE 242
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 938-993 4.00e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 4.00e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770408  938 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 993
Cdd:cd20814      1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 202-792 5.50e-24

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 110.03  E-value: 5.50e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  202 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLE 281
Cdd:COG1196    209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELEL 283

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  282 VHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLA 361
Cdd:COG1196    284 EEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEA 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  362 ANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsdksRLLELETRLREVSLEHEEQKLE 441
Cdd:COG1196    364 EEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEE-----------ALLERLERLEEELEELEEALAE 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  442 LKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeEEIQALTAHRDEIQRKFDALRnsctvitdLEE 521
Cdd:COG1196    433 LEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL-----------EEAALLEAALAELLEELAEAA--------ARL 493

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  522 QLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTT---- 597
Cdd:COG1196    494 LLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAkagr 573

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  598 CTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKA 677
Cdd:COG1196    574 ATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEG 653

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  678 EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQ 757
Cdd:COG1196    654 EGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAE 733

                          570       580       590
                   ....*....|....*....|....*....|....*
gi 1039770408  758 EALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 792
Cdd:COG1196    734 REELLEELLEEEELLEEEALEELPEPPDLEELERE 768
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 72-859 5.36e-22

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 103.98  E-value: 5.36e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   72 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 137
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  138 EEFKRKANECQHKLmkvvshpprgdsggtalddlhkmqghagltsakdqgkpevgeYSKLEKINAEQQlKIQELQEKLEK 217
Cdd:TIGR02168  277 SELEEEIEELQKEL------------------------------------------YALANEISRLEQ-QKQILRERLAN 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  218 AVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgikkklVEAEELEEKHREAQVSAQHLEVHLKQKEQHYE----- 292
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDELAEELAELEEKLEELK------EELESLEAELEELEAELEELESRLEELEEQLEtlrsk 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  293 -----EKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQK-----AMINAMDSKIRSLEQRIVELSEANKLAA 362
Cdd:TIGR02168  388 vaqleLQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAElkelqAELEELEEELEELQEELERLEEALEELR 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  363 NSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKiSHQDHSDKSRLLEL-------ETRLrEVSLEH 435
Cdd:TIGR02168  468 EELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKN-QSGLSGILGVLSELisvdegyEAAI-EAALGG 545

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  436 EEQKLELKRQLTELQL--SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC 513
Cdd:TIGR02168  546 RLQAVVVENLNAAKKAiaFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGV 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  514 TVITDLEEQLNQLTEDNAELNnqNFYLSKQLDEASG--------ANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSA 585
Cdd:TIGR02168  626 LVVDDLDNALELAKKLRPGYR--IVTLDGDLVRPGGvitggsakTNSSILERRREIEELEEKIEELEEKIAELEKALAEL 703

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  586 PDLQT-----MEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQR 660
Cdd:TIGR02168  704 RKELEeleeeLEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  661 ITESRQVVELAVKEHKA---EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAK 737
Cdd:TIGR02168  784 IEELEAQIEQLKEELKAlreALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  738 LQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIqvlySHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKK 817
Cdd:TIGR02168  864 LEELIEELESELEALLNERASLEEALALLRSELEELSEELREL----ESKRSELRRELEELREKLAQLELRLEGLEVRID 939

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|...
gi 1039770408  818 GLFSRRKEDPALPTQVPLQ-YNELKLALEKEKARCAELEEALQ 859
Cdd:TIGR02168  940 NLQERLSEEYSLTLEEAEAlENKIEDDEEEARRRLKRLENKIK 982
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 193-774 1.18e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 96.16  E-value: 1.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNRE--------DSSEGIKKKLVEAE 264
Cdd:COG1196    233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEyellaelaRLEQDIARLEERRR 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  265 ELEEKHREAQVSAQHLEvhlkQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEkgkILSEQKAMINAMDSKI 344
Cdd:COG1196    313 ELEERLEELEEELAELE----EELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLE---AEAELAEAEEELEELA 385

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  345 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdkSRLLEL 424
Cdd:COG1196    386 EELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEE--------AELEEE 457

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  425 ETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteLEETTAEAEEEIQALTAHRDEIQR 504
Cdd:COG1196    458 EEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK--AALLLAGLRGLAGAVAVLIGVEAA 535

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  505 KFDALRNSctvitDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG--ANDEIVQLRSEVDHLRREITEREMQLTSQKQAQ 582
Cdd:COG1196    536 YEAALEAA-----LAAALQNIVVEDDEVAAAAIEYLKAAKAGRATflPLDKIRARAALAAALARGAIGAAVDLVASDLRE 610

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  583 LSAPDLQTMEAlkttctmLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRIT 662
Cdd:COG1196    611 ADARYYVLGDT-------LLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA-GGSLTGGSRRELLAALLEAEAELE 682

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  663 ESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM 742
Cdd:COG1196    683 ELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDL 762

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*.
gi 1039770408  743 DLQKNHIFRLTQGLQE-------ALD-------RADLLKTERSDLE 774
Cdd:COG1196    763 EELERELERLEREIEAlgpvnllAIEeyeeleeRYDFLSEQREDLE 808
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 199-873 4.67e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 94.35  E-value: 4.67e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  199 KINAEQQLKIQELQEKLEKAVKAS-----TEATELLQNIRQAKERAERELE----KLHNREDSSEGIKKKLVEAEELEEK 269
Cdd:TIGR02168  206 ERQAEKAERYKELKAELRELELALlvlrlEELREELEELQEELKEAEEELEeltaELQELEEKLEELRLEVSELEEEIEE 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  270 HREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQ 349
Cdd:TIGR02168  286 LQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  350 RIVELSEANKlaansslftqrnmkAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLr 429
Cdd:TIGR02168  366 ELEELESRLE--------------ELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKL- 430

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  430 evsleHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQRkfdaL 509
Cdd:TIGR02168  431 -----EEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAE--------------QALDAAERELAQ----L 487

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  510 RNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandEIVQLRSEvdhLRREITE-----REMQLTSQKQAQLS 584
Cdd:TIGR02168  488 QARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLS----ELISVDEG---YEAAIEAalggrLQAVVVENLNAAKK 560

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  585 APDLQTmEALKTTCTMLEEQVL---DLEALNDELLEKERQWEAWRSVLGDEKSQFEcrvRELQRMLD-----------TE 650
Cdd:TIGR02168  561 AIAFLK-QNELGRVTFLPLDSIkgtEIQGNDREILKNIEGFLGVAKDLVKFDPKLR---KALSYLLGgvlvvddldnaLE 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  651 KQSRARADQRIT-------ESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLemnaRSLQQKLET 723
Cdd:TIGR02168  637 LAKKLRPGYRIVtldgdlvRPGGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAEL----RKELEELEE 712

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  724 ERELKQRLLEEqakLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEniqvLYSHEKVKMEGTISQQTKLID 803
Cdd:TIGR02168  713 ELEQLRKELEE---LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIE----ELEERLEEAEEELAEAEAEIE 785

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  804 FLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAA 873
Cdd:TIGR02168  786 ELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIE 855
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 57-705 7.34e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 90.38  E-value: 7.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   57 SLKRSLEQARmevsqeddKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLA 136
Cdd:COG1196    204 PLERQAEKAE--------RYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  137 AEEFKRKANECQHKLMKVVShpprgdsggtalddlhkmqghagltsakdqgkpevgEYSKLEKINAEQQLKIQELQEKLE 216
Cdd:COG1196    276 LEELELELEEAQAEEYELLA------------------------------------ELARLEQDIARLEERRRELEERLE 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  217 KAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgikKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIK 296
Cdd:COG1196    320 ELEEELAELEEELEELEEELEELEEELEEAEEELEEAE---AELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAA 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  297 VLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQE 376
Cdd:COG1196    397 ELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLE 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  377 EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLE------LKRQLTELQ 450
Cdd:COG1196    477 AALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEaalaaaLQNIVVEDD 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  451 LSLQERESQLTALQAARAA---LESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLT 527
Cdd:COG1196    557 EVAAAAIEYLKAAKAGRATflpLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAAL 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  528 EDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSApdlqtmealkttctmLEEQVLD 607
Cdd:COG1196    637 RRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELE---------------LEEALLA 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  608 LEALNDELLEKERQWEAWRSVLGDEKSQFE-CRVRELQRMLDTEKQSRARADQRITE--SRQVVELAVKEHKAEI----- 679
Cdd:COG1196    702 EEEEERELAEAEEERLEEELEEEALEEQLEaEREELLEELLEEEELLEEEALEELPEppDLEELERELERLEREIealgp 781

                          650       660
                   ....*....|....*....|....*....
gi 1039770408  680 ---LALQQaLKEQKLKAESLSDKLNDLEK 705
Cdd:COG1196    782 vnlLAIEE-YEELEERYDFLSEQREDLEE 809
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 193-571 9.67e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 90.12  E-value: 9.67e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLhnredssegiKKKLVEAEELEEKHRE 272
Cdd:TIGR02168  678 EIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISAL----------RKDLARLEAEVEQLEE 747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  273 AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV 352
Cdd:TIGR02168  748 RIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLE 827

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  353 ELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVs 432
Cdd:TIGR02168  828 SLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL- 906

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  433 lehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRqakteleettAEAEEEIQALTAHRDEIQRKFDALRNS 512
Cdd:TIGR02168  907 ---ESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLS----------EEYSLTLEEAEALENKIEDDEEEARRR 973

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770408  513 ctvITDLEEQLNQLTEDN-------AELNNQNFYLSKQLDEASGAndeIVQLRSEVDHLRREITER 571
Cdd:TIGR02168  974 ---LKRLENKIKELGPVNlaaieeyEELKERYDFLTAQKEDLTEA---KETLEEAIEEIDREARER 1033
PTZ00121 PTZ00121
MAEBL; Provisional
 5-774 1.42e-17

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 89.82  E-value: 1.42e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVElKASETQRSllEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIR 84
Cdd:PTZ00121  1112 EEARKAEEAKKKAEDARKAEEARKAEDAR-KAEEARKA--EDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVR 1188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   85 --EQSRKLQEIKEQEYQAQVEEMRlmmnQLEEdlvsARRrsdlYESELR-ESRLAAEEFKRKANECQHklmkvvSHPPRG 161
Cdd:PTZ00121  1189 kaEELRKAEDARKAEAARKAEEER----KAEE----ARK----AEDAKKaEAVKKAEEAKKDAEEAKK------AEEERN 1250

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  162 DSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKI-------NAEQQLKIQELQEKLEKAVKASteatELLQNIRQ 234
Cdd:PTZ00121  1251 NEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKkkadeakKAEEKKKADEAKKKAEEAKKAD----EAKKKAEE 1326

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  235 AKERAERELEKLHNREDSSEGIKKklveaeELEEKHREAQVSAQHLEVHLKQKEqhyEEKIKVldNQIKKDLADKESLEN 314
Cdd:PTZ00121  1327 AKKKADAAKKKAEEAKKAAEAAKA------EAEAAADEAEAAEEKAEAAEKKKE---EAKKKA--DAAKKKAEEKKKADE 1395

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  315 MMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQEEMISELRQQKfylETQAG 394
Cdd:PTZ00121  1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKAD--EAKKKAEEAKKADEAKKKAEEAKKAEEAKKK---AEEAK 1470

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  395 KLEAQNRKLEE--QLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESqltalQAARAALEs 472
Cdd:PTZ00121  1471 KADEAKKKAEEakKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA-----DEAKKAEE- 1544

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  473 qLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvitdleEQLNQLTEDNAELNNQNFYLSKQLDEASGAND 552
Cdd:PTZ00121  1545 -KKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKA--------EEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA 1615

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  553 EIVQLRSEvdHLRREITEREMQLTSQKQaqlSAPDLQTMEALKTTctmLEEQVLDLEALNDELLEKERQWEAWRSVLGDE 632
Cdd:PTZ00121  1616 EEAKIKAE--ELKKAEEEKKKVEQLKKK---EAEEKKKAEELKKA---EEENKIKAAEEAKKAEEDKKKAEEAKKAEEDE 1687

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  633 KSQFECRVRELQRMLDTEkQSRARADQRITESRQVVElAVKEHKAEILALQQALKEQKLKAESLsdKLNDLEKK---HAM 709
Cdd:PTZ00121  1688 KKAAEALKKEAEEAKKAE-ELKKKEAEEKKKAEELKK-AEEENKIKAEEAKKEAEEDKKKAEEA--KKDEEEKKkiaHLK 1763

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039770408  710 LEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLE 774
Cdd:PTZ00121  1764 KEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEME 1828
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 22-877 7.47e-17

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 86.95  E-value: 7.47e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   22 EVEAVLSQKEVElkasetqRSLLEQDLATYItecssLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEyqaq 101
Cdd:pfam02463  143 KIEIIAMMKPER-------RLEIEEEAAGSR-----LKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQA---- 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  102 veemrlmmnqleedlvsarrrsdlyESELRESRLAAEEFKRKANECQHKLMKVVshpprgdsgGTALDDLHKMQGHAGLT 181
Cdd:pfam02463  207 -------------------------KKALEYYQLKEKLELEEEYLLYLDYLKLN---------EERIDLLQELLRDEQEE 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  182 SAKDQGKPEVGEySKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV 261
Cdd:pfam02463  253 IESSKQEIEKEE-EKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELK 331

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  262 ----EAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAmI 337
Cdd:pfam02463  332 kekeEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQL-L 410

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  338 NAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSD 417
Cdd:pfam02463  411 LELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLL 490

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  418 KSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQER---------ESQLTALQAARAALESQLRQAKTELEETTAEA 488
Cdd:pfam02463  491 SRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGrlgdlgvavENYKVAISTAVIVEVSATADEVEERQKLVRAL 570

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  489 EEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSkqldEASGANDEIVQLRSEVDHLRREI 568
Cdd:pfam02463  571 TELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAK----VVEGILKDTELTKLKESAKAKES 646

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  569 TEREMQLTSQKQAQLSapdLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLD 648
Cdd:pfam02463  647 GLRKGVSLEEGLAEKS---EVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELL 723

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  649 TEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL---ETER 725
Cdd:pfam02463  724 ADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLkaqEEEL 803

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  726 ELKQRLLEEQAKLQQQMDLQKNH---------------IFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVK 790
Cdd:pfam02463  804 RALEEELKEEAELLEEEQLLIEQeekikeeeleelaleLKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQK 883

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  791 -------MEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRI 863
Cdd:pfam02463  884 lkdelesKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNK 963

                          890
                   ....*....|....
gi 1039770408  864 ELRSAREEAAHRKA 877
Cdd:pfam02463  964 RLLLAKEELGKVNL 977
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 193-729 3.57e-16

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 84.30  E-value: 3.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKEraerELEKlhnredssegiKKKLVEAEELEEKHRE 272
Cdd:TIGR04523  125 ELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKE----ELEN-----------ELNLLEKEKLNIQKNI 189

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  273 AQVSAQHLEVHLK-QKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSE-QKAMINAMDSK---IRSL 347
Cdd:TIGR04523  190 DKIKNKLLKLELLlSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNtQTQLNQLKDEQnkiKKQL 269

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  348 EQRIVELSEANKLAANsslfTQRNMKAQEEMISELRQQKF-----YLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLL 422
Cdd:TIGR04523  270 SEKQKELEQNNKKIKE----LEKQLNQLKSEISDLNNQKEqdwnkELKSELKNQEKKLEEIQNQISQNNKIISQLNEQIS 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  423 ELETRLREVSLEHEEQKLELKRQLTELQLSLQERES---QLTALQAARAALESQLRQAKteleETTAEAEEEIQALTAHR 499
Cdd:TIGR04523  346 QLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSykqEIKNLESQINDLESKIQNQE----KLNQQKDEQIKKLQQEK 421

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  500 DEIQRKFDALRNSctvITDLEEQLNQLTEDNAEL----NNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL 575
Cdd:TIGR04523  422 ELLEKEIERLKET---IIKNNSEIKDLTNQDSVKeliiKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKEL 498

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  576 tsqkqaqlsapdlqtmEALKTTCTMLEEQVLDLEALNDELLEKERQWEAwrsvlgdEKSQFECRVRELQRMLDTEKQSRA 655
Cdd:TIGR04523  499 ----------------KKLNEEKKELEEKVKDLTKKISSLKEKIEKLES-------EKKEKESKISDLEDELNKDDFELK 555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  656 RA---------DQRITESRQV----------VELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARS 716
Cdd:TIGR04523  556 KEnlekeidekNKEIEELKQTqkslkkkqeeKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKN 635

                          570
                   ....*....|....
gi 1039770408  717 LQQKLET-ERELKQ 729
Cdd:TIGR04523  636 IKSKKNKlKQEVKQ 649
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-723 3.97e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 84.72  E-value: 3.97e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH 81
Cdd:TIGR02168  244 LQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEA 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   82 DIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPP 159
Cdd:TIGR02168  324 QLEELESKLDELAEElaELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIE 403

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  160 RGDSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYS-KLEKINAEqqlkIQELQEKLEKAVKASTEATELLQNIRQAKER 238
Cdd:TIGR02168  404 RLEARLERLEDRRERLQQEIEELLKKLEEAELKELQaELEELEEE----LEELQEELERLEEALEELREELEEAEQALDA 479

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  239 AERELEKLHNREDS-----------SEGIKKKLVEAEEL-------------EEKHREA-----QVSAQHLEV------- 282
Cdd:TIGR02168  480 AERELAQLQARLDSlerlqenlegfSEGVKALLKNQSGLsgilgvlselisvDEGYEAAieaalGGRLQAVVVenlnaak 559

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  283 ----HLKQKE----------QHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSL- 347
Cdd:TIGR02168  560 kaiaFLKQNElgrvtflpldSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAk 639

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  348 ----EQRIVEL-----------SEANKLAANSSLFTQRN-------MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE 405
Cdd:TIGR02168  640 klrpGYRIVTLdgdlvrpggviTGGSAKTNSSILERRREieeleekIEELEEKIAELEKALAELRKELEELEEELEQLRK 719

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  406 QLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 482
Cdd:TIGR02168  720 ELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEleaEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELK 799

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  483 ETTAEAEEEIQALTAHRDEIQRKFDALRNSC-------TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIV 555
Cdd:TIGR02168  800 ALREALDELRAELTLLNEEAANLRERLESLErriaateRRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALL 879

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  556 QLRSEVDHLRREItEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLE-KERQWEAWRSVLGDEKS 634
Cdd:TIGR02168  880 NERASLEEALALL-RSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNlQERLSEEYSLTLEEAEA 958

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  635 QFECRVRELQRMldteKQSRARADQRITESRQVVELAVKEHKaEILALQQALKEQKlkaESLSDKLNDLEKkhAMLEMNA 714
Cdd:TIGR02168  959 LENKIEDDEEEA----RRRLKRLENKIKELGPVNLAAIEEYE-ELKERYDFLTAQK---EDLTEAKETLEE--AIEEIDR 1028


                   ....*....
gi 1039770408  715 RSLQQKLET 723
Cdd:TIGR02168 1029 EARERFKDT 1037
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 287-864 6.55e-16

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 83.53  E-value: 6.55e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  287 KEQHYEEKIKVLDNQIKKDLADKESLEnmmqrheeeahekgKILSEQKAMINAMDSKIRSLEQRIVEL--------SEAN 358
Cdd:TIGR04523   34 EEKQLEKKLKTIKNELKNKEKELKNLD--------------KNLNKDEEKINNSNNKIKILEQQIKDLndklkknkDKIN 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  359 KLAANSSLFT------QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREvs 432
Cdd:TIGR04523  100 KLNSDLSKINseikndKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNL-- 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  433 LEHEEQKLE-----LKRQLTELQLSL----------QERESQLTALQAARAALES---QLRQAKTELEETTAEAEEEIQA 494
Cdd:TIGR04523  178 LEKEKLNIQknidkIKNKLLKLELLLsnlkkkiqknKSLESQISELKKQNNQLKDnieKKQQEINEKTTEISNTQTQLNQ 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  495 LTAHRDEIQRKFDA----LRNSCTVITDLEEQLNQLTEDNAELNNQnfylsKQLDEASGANDEIVQLRSEVDHLRREITE 570
Cdd:TIGR04523  258 LKDEQNKIKKQLSEkqkeLEQNNKKIKELEKQLNQLKSEISDLNNQ-----KEQDWNKELKSELKNQEKKLEEIQNQISQ 332

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  571 REMQLTSQKqaqlsapdlQTMEALKTTCTMLEeqvLDLEALNDELLEKERQWEAWRS---VLGDEKSQFECRVRELQRML 647
Cdd:TIGR04523  333 NNKIISQLN---------EQISQLKKELTNSE---SENSEKQRELEEKQNEIEKLKKenqSYKQEIKNLESQINDLESKI 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  648 DTEKQSRARADQRITESRQVVELAVKEH---KAEILALQQALKE-------QKLKAESLSDKLNDLEKKHAMLEMNARSL 717
Cdd:TIGR04523  401 QNQEKLNQQKDEQIKKLQQEKELLEKEIerlKETIIKNNSEIKDltnqdsvKELIIKNLDNTRESLETQLKVLSRSINKI 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  718 QQKLE-TERELKQRlLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQvlYSHEKVKMEGTIS 796
Cdd:TIGR04523  481 KQNLEqKQKELKSK-EKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLE--DELNKDDFELKKE 557

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770408  797 QQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIE 864
Cdd:TIGR04523  558 NLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKE 625
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 10-817 1.24e-15

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 83.10  E-value: 1.24e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDI--REQS 87
Cdd:pfam02463  264 EEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIeeLEKE 343

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   88 RKLQEIKEQEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVShpprgdsggtA 167
Cdd:pfam02463  344 LKELEIKREAEEEEEEELE----KLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQ----------L 409

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  168 LDDLHKMQGHAgLTSAKDQGKPEVGEyskLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLH 247
Cdd:pfam02463  410 LLELARQLEDL-LKEEKKEELEILEE---EEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQ 485

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  248 NREDSSEgikKKLVEAEELEEKHREAqvsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKG 327
Cdd:pfam02463  486 LELLLSR---QKLEERSQKESKARSG------LKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSAT 556

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  328 KILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL 407
Cdd:pfam02463  557 ADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTK 636

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  408 EKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLtalqaarAALESQLRQAKTELEETTAE 487
Cdd:pfam02463  637 LKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESEL-------AKEEILRRQLEIKKKEQREK 709

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  488 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgandeiVQLRSEVDHLRRE 567
Cdd:pfam02463  710 EELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSE--------LSLKEKELAEERE 781

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  568 ITEREMQLTSQKqaqlsapdlQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfECRVRELQRML 647
Cdd:pfam02463  782 KTEKLKVEEEKE---------EKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELAL-ELKEEQKLEKL 851

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  648 DTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETEREL 727
Cdd:pfam02463  852 AEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILL 931

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  728 KQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKlIDFLQA 807
Cdd:pfam02463  932 KYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEK-KKLIRA 1010

                          810
                   ....*....|
gi 1039770408  808 KMDQPAKKKK 817
Cdd:pfam02463 1011 IIEETCQRLK 1020
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 193-774 1.76e-15

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 82.32  E-value: 1.76e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKE--RAERELEKLHNREDSSEGIKKKLVEAEELEEKH 270
Cdd:TIGR00618  227 ELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEElrAQEAVLEETQERINRARKAAPLAAHIKAVTQIE 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  271 REAQVSAQHLEVHLKQKEQHYEEKIKVLDNQikKDLADKESLENMMQRHEEE---AHEKGKILSEQKAMINAMDSKIRSL 347
Cdd:TIGR00618  307 QQAQRIHTELQSKMRSRAKLLMKRAAHVKQQ--SSIEEQRRLLQTLHSQEIHirdAHEVATSIREISCQQHTLTQHIHTL 384

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  348 EQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETR 427
Cdd:TIGR00618  385 QQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQES 464

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  428 LRevSLEHEEQKLELKRQLTelqlslqERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFD 507
Cdd:TIGR00618  465 AQ--SLKEREQQLQTKEQIH-------LQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQ 535

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  508 ALRNSCTVITDLEEQLNQLTEDNAELNNQ------NFYLSKQLDEASGANDEIV-QLRSEVDHLRREITEREMQLTSQKQ 580
Cdd:TIGR00618  536 TYAQLETSEEDVYHQLTSERKQRASLKEQmqeiqqSFSILTQCDNRSKEDIPNLqNITVRLQDLTEKLSEAEDMLACEQH 615

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  581 AQLSA--PDLQTMEALKTTCTMLEEQVLDLEALNDELLE--KERQWEAWRSVLGDEKSQFECRVRELQRMldtekQSRAR 656
Cdd:TIGR00618  616 ALLRKlqPEQDLQDVRLHLQQCSQELALKLTALHALQLTltQERVREHALSIRVLPKELLASRQLALQKM-----QSEKE 690

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  657 ADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 736
Cdd:TIGR00618  691 QLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEV 770

                          570       580       590
                   ....*....|....*....|....*....|....*....
gi 1039770408  737 KLQQQMDLQKNHIFRLTQGLQEALD-RADLLKTERSDLE 774
Cdd:TIGR00618  771 TAALQTGAELSHLAAEIQFFNRLREeDTHLLKTLEAEIG 809
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 9-568 2.55e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 78.44  E-value: 2.55e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    9 MEQEMTRLHRRVSEVEAVLS----QKEV-----ELKASETQRSL---------LEQDLATYITECSSLKRSLEQARMEVS 70
Cdd:COG1196    184 TEENLERLEDILGELERQLEplerQAEKaeryrELKEELKELEAellllklreLEAELEELEAELEELEAELEELEAELA 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   71 QEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRlmmnqLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHK 150
Cdd:COG1196    264 ELEAELEELRLELEELELELEEAQAEEYELLAELAR-----LEQDIARLEERRRELEERLEELEEELAELEEELEELEEE 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  151 LmkvvshpprgDSGGTALDDLHKMQGHAGLTSAKDQgkpevgeySKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQ 230
Cdd:COG1196    339 L----------EELEEELEEAEEELEEAEAELAEAE--------EALLEAEAELAEAEEELEELAEELLEALRAAAELAA 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  231 NIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLE--------------VHLKQKEQHYEEKIK 296
Cdd:COG1196    401 QLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEaeleeeeeallellAELLEEAALLEAALA 480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  297 VLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQE 376
Cdd:COG1196    481 ELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAA 560

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  377 EMISELRQQK-----FYLETQAGKLEAQNRKLEEQLEK-----------------------------ISHQDHSDKSRLL 422
Cdd:COG1196    561 AAIEYLKAAKagratFLPLDKIRARAALAAALARGAIGaavdlvasdlreadaryyvlgdtllgrtlVAARLEAALRRAV 640

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  423 ELETRLREVSLEHEEQkleLKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEI 502
Cdd:COG1196    641 TLAGRLREVTLEGEGG---SAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERL 717

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770408  503 QRKFDALRNSCTVITDLEEQLNQLTEDNAElnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREI 568
Cdd:COG1196    718 EEELEEEALEEQLEAEREELLEELLEEEEL-------LEEEALEELPEPPDLEELERELERLEREI 776
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 197-934 3.88e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 78.24  E-value: 3.88e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  197 LEKINAEQQLKIQELQEKLekavkasTEATELLQN----IRQAKERAERELEKLHNREDSSEGIKKKlvEAEELEEKHRE 272
Cdd:pfam15921   76 IERVLEEYSHQVKDLQRRL-------NESNELHEKqkfyLRQSVIDLQTKLQEMQMERDAMADIRRR--ESQSQEDLRNQ 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  273 AQVSAQHLEVHLKQKEQHYEEKikvlDNQIkkdladkESLENMMQRHEEEAHE-----------KGKILSEQKAM----- 336
Cdd:pfam15921  147 LQNTVHELEAAKCLKEDMLEDS----NTQI-------EQLRKMMLSHEGVLQEirsilvdfeeaSGKKIYEHDSMstmhf 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  337 ----------INAMDSKIRSLEQRIVELSEA-NKLAANSS----LFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNR 401
Cdd:pfam15921  216 rslgsaiskiLRELDTEISYLKGRIFPVEDQlEALKSESQnkieLLLQQHQDRIEQLISEHEVEITGLTEKASSARSQAN 295

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  402 KLEEQLEKISHQDHSDKS----RLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 477
Cdd:pfam15921  296 SIQSQLEIIQEQARNQNSmymrQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNL 375

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  478 KTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQ-----------LTEDNAELNNQnfyLSKQLDE 546
Cdd:pfam15921  376 DDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDrnmevqrlealLKAMKSECQGQ---MERQMAA 452

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  547 ASGANDEI-------VQLRSEVDHLRR---EITEREMQLTS-------------QKQAQLSAPD-------------LQT 590
Cdd:pfam15921  453 IQGKNESLekvssltAQLESTKEMLRKvveELTAKKMTLESsertvsdltaslqEKERAIEATNaeitklrsrvdlkLQE 532

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  591 MEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGD-----------------EKSQFECRVRELQRMLDTEKQS 653
Cdd:pfam15921  533 LQHLKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENmtqlvgqhgrtagamqvEKAQLEKEINDRRLELQEFKIL 612

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  654 RARADQRITE-SRQVVELAVKEHK-----AEILALQQALKEQKLK----AESLSDKLNDLEKKHAMLEMNARSLQQKLE- 722
Cdd:pfam15921  613 KDKKDAKIRElEARVSDLELEKVKlvnagSERLRAVKDIKQERDQllneVKTSRNELNSLSEDYEVLKRNFRNKSEEMEt 692

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  723 TERELKQRLLEEQAKLQQ------QMDLQKNHIFRLTQGLQEALD----RADLLKTERSDLEYQLENI---QVLYSHEKV 789
Cdd:pfam15921  693 TTNKLKMQLKSAQSELEQtrntlkSMEGSDGHAMKVAMGMQKQITakrgQIDALQSKIQFLEEAMTNAnkeKHFLKEEKN 772

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  790 KMegtiSQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPAlptqvplqynELKLALEKEKARCAELEEALQktRIELRSAR 869
Cdd:pfam15921  773 KL----SQELSTVATEKNKMAGELEVLRSQERRLKEKVA----------NMEVALDKASLQFAECQDIIQ--RQEQESVR 836

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  870 EEAAHR---KATDHP-HPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSR-RKESSTPEEFSRRLKE 934
Cdd:pfam15921  837 LKLQHTldvKELQGPgYTSNSSMKPRLLQPASFTRTHSNVPSSQSTASFLSHHsRKTNALKEDPTRDLKQ 906
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
215-792 8.62e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.64  E-value: 8.62e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  215 LEKAVKASTEATELLQNIRQAKERAERELEklhnredSSEGIKKKLVEAE-ELEEKHREAQvsaqhlevHLKQKEQHYEE 293
Cdd:PRK03918   157 LDDYENAYKNLGEVIKEIKRRIERLEKFIK-------RTENIEELIKEKEkELEEVLREIN--------EISSELPELRE 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  294 KIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKI---LSEQKAMINAMDSKIRSLEQRIVELSEANKLAansslftqR 370
Cdd:PRK03918   222 ELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLeekIRELEERIEELKKEIEELEEKVKELKELKEKA--------E 293

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  371 NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhSDKSRLLELETRLREV-----SLEHEEQKLELKRQ 445
Cdd:PRK03918   294 EYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELE----EKEERLEELKKKLKELekrleELEERHELYEEAKA 369

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  446 LTELQLSLQERESQLTALQAARAALEsqLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNS------CTVITDL 519
Cdd:PRK03918   370 KKEELERLKKRLTGLTPEKLEKELEE--LEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkgkcpvCGRELTE 447

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  520 EEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM--QLTSQKQaQLSAPDLQTMEALKTT 597
Cdd:PRK03918   448 EHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELaeQLKELEE-KLKKYNLEELEKKAEE 526

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  598 CTMLEEQVLDLEA----LNDELLEKErqweawrsvlgdeksQFECRVRELQRMLDTEKQSRARADQRITE----SRQVVE 669
Cdd:PRK03918   527 YEKLKEKLIKLKGeiksLKKELEKLE---------------ELKKKLAELEKKLDELEEELAELLKELEElgfeSVEELE 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  670 LAVKEHKA---EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQ-AKLQQQMDLQ 745
Cdd:PRK03918   592 ERLKELEPfynEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEyEELREEYLEL 671

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*..
gi 1039770408  746 KNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIqvlyshEKVKME 792
Cdd:PRK03918   672 SRELAGLRAELEELEKRREEIKKTLEKLKEELEER------EKAKKE 712
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
9-572 1.17e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.26  E-value: 1.17e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    9 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQdLATYITECSSLKRSLEQarmEVSQEDDKALQLLHDIREQSR 88
Cdd:PRK03918   198 KEKELEEVLREINEISSELPELREELEKLEKEVKELEE-LKEEIEELEKELESLEG---SKRKLEEKIRELEERIEELKK 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   89 KLQEIKEQEyqAQVEEMRlmmnQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKlmkvvshpprgdsggtaL 168
Cdd:PRK03918   274 EIEELEEKV--KELKELK----EKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEER-----------------I 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  169 DDLHKMQGHAG-LTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQE-KLEKAVKASTEATELLQNIRQAKERAERELEKL 246
Cdd:PRK03918   331 KELEEKEERLEeLKKKLKELEKRLEELEERHELYEEAKAKKEELERlKKRLTGLTPEKLEKELEELEKAKEEIEEEISKI 410

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  247 HNREDSSEGIKKKLVEA-EELEEKHREAQVSAQHLEvhlkqkEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHE 325
Cdd:PRK03918   411 TARIGELKKEIKELKKAiEELKKAKGKCPVCGRELT------EEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRE 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  326 KGKILSEQKAMI--NAMDSKIRSLEQRIVELsEANKLAANSSLFTqrnmKAQEEMIsELRQQKFYLETQAGKLEAQNRKL 403
Cdd:PRK03918   485 LEKVLKKESELIklKELAEQLKELEEKLKKY-NLEELEKKAEEYE----KLKEKLI-KLKGEIKSLKKELEKLEELKKKL 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  404 EEQLEKIshqdHSDKSRLLELETRLREVSLEHEEqklELKRQLTELQ------LSLQERESQLTALQAARAALESQLRQA 477
Cdd:PRK03918   559 AELEKKL----DELEEELAELLKELEELGFESVE---ELEERLKELEpfyneyLELKDAEKELEREEKELKKLEEELDKA 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  478 ktelEETTAEAEEEIQALTAHRDEIQRKFDalrnsctvitdlEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIvql 557
Cdd:PRK03918   632 ----FEELAETEKRLEELRKELEELEKKYS------------EEEYEELREEYLELSRELAGLRAELEELEKRREEI--- 692

                          570
                   ....*....|....*
gi 1039770408  558 RSEVDHLRREITERE 572
Cdd:PRK03918   693 KKTLEKLKEELEERE 707
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 202-877 1.57e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 76.26  E-value: 1.57e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  202 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLhnredssegikkklveaeeleEKHREaqvsaqhle 281
Cdd:TIGR02169  166 AEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKA---------------------ERYQA--------- 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  282 vhLKQKEQHYEEKIKVldNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEankla 361
Cdd:TIGR02169  216 --LLKEKREYEGYELL--KEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGE----- 286

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  362 aNSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKSRLLELETRLREVSLEHEEQKLE 441
Cdd:TIGR02169  287 -EEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKL-------LAEIEELEREIEEERKRRDKLTEE 358

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  442 LKRQLTELQLSLQERESQLTALQAARAALeSQLRQAkteleettaeaeeeIQALTAHRDEIQRKFDAlrnsctvitdLEE 521
Cdd:TIGR02169  359 YAELKEELEDLRAELEEVDKEFAETRDEL-KDYREK--------------LEKLKREINELKRELDR----------LQE 413

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  522 QLNQLTEDNAELNNqnfylskqldEASGANDEIVQLRSEVDHLRREITEREMQLtSQKQAQLSAPDlQTMEALKTTCTML 601
Cdd:TIGR02169  414 ELQRLSEELADLNA----------AIAGIEAKINELEEEKEDKALEIKKQEWKL-EQLAADLSKYE-QELYDLKEEYDRV 481

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  602 EEQvldLEALNDELLEKERQWEAWRS----------VLGDEKSQFECRVREL-----QRMLDTEKQSRARADQRITESRQ 666
Cdd:TIGR02169  482 EKE---LSKLQRELAEAEAQARASEErvrggraveeVLKASIQGVHGTVAQLgsvgeRYATAIEVAAGNRLNNVVVEDDA 558

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  667 VVELAV---KEHK---AEILALQQALKEQKLKAESLSDKLND-------------------------------------- 702
Cdd:TIGR02169  559 VAKEAIellKRRKagrATFLPLNKMRDERRDLSILSEDGVIGfavdlvefdpkyepafkyvfgdtlvvedieaarrlmgk 638

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  703 ----------LEKKHAM---------LEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA---- 759
Cdd:TIGR02169  639 yrmvtlegelFEKSGAMtggsraprgGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDAsrki 718

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  760 ---LDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFS-RRKEDPALPTQVPL 835
Cdd:TIGR02169  719 geiEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDlEARLSHSRIPEIQA 798

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|..
gi 1039770408  836 QYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 877
Cdd:TIGR02169  799 ELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQE 840
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 16-860 1.69e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 75.87  E-value: 1.69e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   16 LHRRVSEVEAVLSQKEVElkASETQRSLLEQDLAtyitecsSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKE 95
Cdd:TIGR02169  216 LLKEKREYEGYELLKEKE--ALERQKEAIERQLA-------SLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGE 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   96 QEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELREsrlaAEEFKRKANEcqhklmkvvshpprgdsggtaldDLHKMQ 175
Cdd:TIGR02169  287 EEQLRVKEKIG----ELEAEIASLERSIAEKERELED----AEERLAKLEA-----------------------EIDKLL 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  176 ghagltSAKDQGKPEVGEYSK-LEKINAEqqlkIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSE 254
Cdd:TIGR02169  336 ------AEIEELEREIEEERKrRDKLTEE----YAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELK 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  255 GIKKKLVeaEELEEKHREAQVSAQHLEVhLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEahekgkiLSEQK 334
Cdd:TIGR02169  406 RELDRLQ--EELQRLSEELADLNAAIAG-IEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQE-------LYDLK 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  335 AMINAMDSKIRSLEQRIVELsEANKLAANSslfTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE-----QLEK 409
Cdd:TIGR02169  476 EEYDRVEKELSKLQRELAEA-EAQARASEE---RVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEvaagnRLNN 551

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  410 ISHQDHSDKSRLLELETR----------LREVSLEHEEQKLELKRQLTELQLSLQERESQLtalqaaRAALESQLRQAKT 479
Cdd:TIGR02169  552 VVVEDDAVAKEAIELLKRrkagratflpLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKY------EPAFKYVFGDTLV 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  480 ELEETTAEAEEEIQALTAHRDEIQRK-------FDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND 552
Cdd:TIGR02169  626 VEDIEAARRLMGKYRMVTLEGELFEKsgamtggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLD 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  553 EIVQLRSEVDHLRREItEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDe 632
Cdd:TIGR02169  706 ELSQELSDASRKIGEI-EKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALND- 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  633 ksqfecrvreLQRMLDTEKQsraradQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEM 712
Cdd:TIGR02169  784 ----------LEARLSHSRI------PEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKE 847

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  713 NARSLQQKLETERELKQRLLEEQAKLQQQmdlqknhifrltqgLQEALDRADLLKTERSDLEYQLENIQvlyshekvKME 792
Cdd:TIGR02169  848 QIKSIEKEIENLNGKKEELEEELEELEAA--------------LRDLESRLGDLKKERDELEAQLRELE--------RKI 905

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770408  793 GTISQQtklIDFLQAKMDQPAKKKKGLFSRRKE-DPALPTQVPlqYNELKLALEKEKARCAELEEALQK 860
Cdd:TIGR02169  906 EELEAQ---IEKKRKRLSELKAKLEALEEELSEiEDPKGEDEE--IPEEELSLEDVQAELQRVEEEIRA 969
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
10-560 7.58e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 73.92  E-value: 7.58e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRsllEQDLATyITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 89
Cdd:PRK02224   198 EKEEKDLHERLNGLESELAELDEEIERYEEQR---EQARET-RDEADEVLEEHEERREELETLEAEIEDLRETIAETERE 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   90 LQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVvshpprgdsggtald 169
Cdd:PRK02224   274 REELAEE-----VRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEEC--------------- 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  170 dlhkmqgHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKA----VKASTEATELLQNIRQAKERAERELEK 245
Cdd:PRK02224   334 -------RVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAreavEDRREEIEELEEEIEELRERFGDAPVD 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  246 LHNREDSSEgikkklveaeELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD-------NQIKKDLADKESLENMMQR 318
Cdd:PRK02224   407 LGNAEDFLE----------ELREERDELREREAELEATLRTARERVEEAEALLEagkcpecGQPVEGSPHVETIEEDRER 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  319 HEEEAHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQR------NMKAQEEMISELRQQKFYLETQ 392
Cdd:PRK02224   477 VEELEAE----LEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELiaerreTIEEKRERAEELRERAAELEAE 552

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  393 AGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVS--------LEHEEQKLE-LKRQLTELQLSLQERESQLTAL 463
Cdd:PRK02224   553 AEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLErirtllaaIADAEDEIErLREKREALAELNDERRERLAEK 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  464 QAARAALES--------QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCtvitdleEQLNQLTEDNAELNN 535
Cdd:PRK02224   633 RERKRELEAefdearieEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENEL-------EELEELRERREALEN 705

                          570       580
                   ....*....|....*....|....*
gi 1039770408  536 QNFYLSKQLDEASGANDEIVQLRSE 560
Cdd:PRK02224   706 RVEALEALYDEAEELESMYGDLRAE 730
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 195-880 9.04e-13

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 73.85  E-value: 9.04e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  195 SKLEKINAEQQLKIQELQEKLEKAVKASTEAT---ELLQNIRQAKERAERELEKLHNREdssegiKKKLVEAEELEEKhr 271
Cdd:pfam02463  156 LEIEEEAAGSRLKRKKKEALKKLIEETENLAEliiDLEELKLQELKLKEQAKKALEYYQ------LKEKLELEEEYLL-- 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  272 eaqvsaqhlevhLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRI 351
Cdd:pfam02463  228 ------------YLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEE 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  352 VELSEANKLAANSSLFTQRNMKAQEEMI----SELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQdhsdKSRLLELETR 427
Cdd:pfam02463  296 EELKSELLKLERRKVDDEEKLKESEKEKkkaeKELKKEKEEIEELEKELKELEIKREAEEEEEEEL----EKLQEKLEQL 371

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  428 LREVSLEHEEQKLELKRQLTELQLSLQEREsqltaLQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFD 507
Cdd:pfam02463  372 EEELLAKKKLESERLSSAAKLKEEELELKS-----EEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKL 446

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  508 ALRNSCTVITDLEEQLNQLTEDNAELNNQ-------NFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQ 580
Cdd:pfam02463  447 TEEKEELEKQELKLLKDELELKKSEDLLKetqlvklQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIIS 526

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  581 AQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQS-----RA 655
Cdd:pfam02463  527 AHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIdpilnLA 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  656 RADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQ-----KLETERELKQR 730
Cdd:pfam02463  607 QLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSEltkelLEIQELQEKAE 686

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  731 LLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDF-LQAKM 809
Cdd:pfam02463  687 SELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEeKEEEK 766

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770408  810 DQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDH 880
Cdd:pfam02463  767 SELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEE 837
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
58-620 1.11e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 73.17  E-value: 1.11e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   58 LKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 137
Cdd:PRK03918   194 LIKEKEKELEEVLREINEISSELPELREELEKLEKEVKE-----LEELKEEIEELEKELESLEGSKRKLEEKIRELEERI 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  138 EEFKRKANECQHKLMKVvshpprgdsggtalddlhkmqghagltsakDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEK 217
Cdd:PRK03918   269 EELKKEIEELEEKVKEL------------------------------KELKEKAEEYIKLSEFYEEYLDELREIEKRLSR 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  218 avkasteATELLQNIrqakeraERELEKLHNREDSSEGIKKKLveaEELEEKHREaqvsaqhlevhLKQKEQHYEEKIKV 297
Cdd:PRK03918   319 -------LEEEINGI-------EERIKELEEKEERLEELKKKL---KELEKRLEE-----------LEERHELYEEAKAK 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  298 LDN--QIKKDLADK--ESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRN- 371
Cdd:PRK03918   371 KEEleRLKKRLTGLtpEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkGKCPVCGRELTEEHr 450

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  372 ---MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKSRLLELETRLREVSLEHEEQKLE----L 442
Cdd:PRK03918   451 kelLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKYNLEELEKKAEeyekL 530

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  443 KRQLTEL---QLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEE-----------IQALtahrDEIQRKFDA 508
Cdd:PRK03918   531 KEKLIKLkgeIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgfesveeleerLKEL----EPFYNEYLE 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  509 LRNSCTVITDLEEQLNQLTEDnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDL 588
Cdd:PRK03918   607 LKDAEKELEREEKELKKLEEE----------LDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELA 676

                          570       580       590
                   ....*....|....*....|....*....|..
gi 1039770408  589 QTMEALKTTCTMLEEQVLDLEALNDELLEKER 620
Cdd:PRK03918   677 GLRAELEELEKRREEIKKTLEKLKEELEEREK 708
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
291-876 1.47e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 72.79  E-value: 1.47e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  291 YEEKIKVLDNQIKKDLADKESLENMMQRhEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEanKLAANSSLFtqR 370
Cdd:PRK03918   160 YENAYKNLGEVIKEIKRRIERLEKFIKR-TENIEEL---IKEKEKELEEVLREINEISSELPELRE--ELEKLEKEV--K 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  371 NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKSRLLELETRLREV-SLEHEEQK-LELKRQLTE 448
Cdd:PRK03918   232 ELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEEL-------KKEIEELEEKVKELkELKEKAEEyIKLSEFYEE 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  449 LQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTE 528
Cdd:PRK03918   305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEER--------LEELKKKLKELEKRLEELEERHELYEEAKAKKEELER 376

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  529 DNAELNNQNF-YLSKQLDEASGAN----DEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEE 603
Cdd:PRK03918   377 LKKRLTGLTPeKLEKELEELEKAKeeieEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKELLEE 456

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  604 QVLDLEALNDELLEkerqweawrsvLGDEKSQFECRVRELQRMLdtEKQSRARADQRITESRQVVELAVKEHKAEILA-- 681
Cdd:PRK03918   457 YTAELKRIEKELKE-----------IEEKERKLRKELRELEKVL--KKESELIKLKELAEQLKELEEKLKKYNLEELEkk 523

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  682 --LQQALKEQ--KLKAESLS-----DKLNDLEKKHAMLEMNARSLQQKLEterELKQRLLEEQAKLQQQMDLQknhifrl 752
Cdd:PRK03918   524 aeEYEKLKEKliKLKGEIKSlkkelEKLEELKKKLAELEKKLDELEEELA---ELLKELEELGFESVEELEER------- 593

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  753 TQGLQEALDRADLLKTERSDLEYQLENIQVLYShEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDpalptq 832
Cdd:PRK03918   594 LKELEPFYNEYLELKDAEKELEREEKELKKLEE-ELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELRE------ 666

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....
gi 1039770408  833 vplQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRK 876
Cdd:PRK03918   667 ---EYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEERE 707
C1_MgcRacGAP cd20821
protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and ...
 940-994 2.00e-12

protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins; MgcRacGAP, also called Rac GTPase-activating protein 1 (RACGAP1) or protein CYK4, plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling; and ii) after phosphorylation by aurora B, MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain an N-terminal C1 domain, and a C-terminal RhoGAP domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410371  Cd Length: 55  Bit Score: 63.19  E-value: 2.00e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039770408  940 IPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPA 994
Cdd:cd20821      1 RPHRFVSKTVIKPETCVVCGKRIKFGKKALKCKDCRVVCHPDCKDKLPLPCVPTS 55
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 368-873 6.95e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.86  E-value: 6.95e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  368 TQRNMKAQEEMISELRQQKFYLETQAGKLEaQNRKLEEQLEKISH-----QDHSDKSRLLELETRLREVSLEHEEQKLEL 442
Cdd:TIGR02168  184 TRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELallvlRLEELREELEELQEELKEAEEELEELTAEL 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  443 KR---QLTELQLSLQERESQLTALQAA-------RAALESQLRQAK---TELEETTAEAEEEIQALTAHRDEIQRKFDAL 509
Cdd:TIGR02168  263 QEleeKLEELRLEVSELEEEIEELQKElyalaneISRLEQQKQILRerlANLERQLEELEAQLEELESKLDELAEELAEL 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  510 RNsctVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgaNDEIVQLRSEVDHLRREIT-----------------ERE 572
Cdd:TIGR02168  343 EE---KLEELKEELESLEAELEELEAELEELESRLEEL---EEQLETLRSKVAQLELQIAslnneierlearlerleDRR 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  573 MQLTSQKQAQLSAPDLQTMEALKTTC----TMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFE---CRVRELQR 645
Cdd:TIGR02168  417 ERLQQEIEELLKKLEEAELKELQAELeeleEELEELQEELERLEEALEELREELEEAEQALDAAERELAqlqARLDSLER 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  646 MLD------------TEKQSR---------------------------ARADQRITESRQVVELAV---KEH---KAEIL 680
Cdd:TIGR02168  497 LQEnlegfsegvkalLKNQSGlsgilgvlselisvdegyeaaieaalgGRLQAVVVENLNAAKKAIaflKQNelgRVTFL 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  681 AL--------QQALKEQKLKAESLSDKLNDLEKKHAMLEMN----------ARSLQQKLETERELKQR------------ 730
Cdd:TIGR02168  577 PLdsikgteiQGNDREILKNIEGFLGVAKDLVKFDPKLRKAlsyllggvlvVDDLDNALELAKKLRPGyrivtldgdlvr 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  731 ---------------LLE---EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKV--- 789
Cdd:TIGR02168  657 pggvitggsaktnssILErrrEIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKdla 736

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  790 -------KMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTR 862
Cdd:TIGR02168  737 rleaeveQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLN 816

                          650
                   ....*....|.
gi 1039770408  863 IELRSAREEAA 873
Cdd:TIGR02168  817 EEAANLRERLE 827
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 542-873 1.05e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.09  E-value: 1.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  542 KQLDEASGA----NDEIVQLRSEVDHLRR--EITEREMQLTSQK---QAQLSAPDLQTMEA-LKTTCTMLEEQVLDLEAL 611
Cdd:TIGR02168  179 RKLERTRENldrlEDILNELERQLKSLERqaEKAERYKELKAELrelELALLVLRLEELREeLEELQEELKEAEEELEEL 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  612 NDELLEKERQWEAWRsvlgDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEILALQQALKE 688
Cdd:TIGR02168  259 TAELQELEEKLEELR----LEVSELEEEIEELQKELYALANEISRLEQQKqilRERLANLERQLEELEAQLEELESKLDE 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  689 QKLKAESLSDKLNDLEKKHAMLEM---NARSLQQKLETERELKQRLLEEQ----AKLQQQMDLQKNHIFRLTQGLQEALD 761
Cdd:TIGR02168  335 LAEELAELEEKLEELKEELESLEAeleELEAELEELESRLEELEEQLETLrskvAQLELQIASLNNEIERLEARLERLED 414

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  762 RADLLKTERSDLEYQLENIQVLYSHEKVkmegtisqqtklidflqakmdqpAKKKKGLFSRRKEDPALPTQvplqynelk 841
Cdd:TIGR02168  415 RRERLQQEIEELLKKLEEAELKELQAEL-----------------------EELEEELEELQEELERLEEA--------- 462

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1039770408  842 laLEKEKARCAELEEALQKTRIELRSAREEAA 873
Cdd:TIGR02168  463 --LEELREELEEAEQALDAAERELAQLQARLD 492
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 198-734 1.24e-11

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 69.75  E-value: 1.24e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  198 EKINAEQQLKIQElQEKLEKAVKASTEATELLQNI--RQAKERAERELEKLHNRE---DSSEGIKKKLVEAEELEekhre 272
Cdd:pfam05483  130 EKVSLKLEEEIQE-NKDLIKENNATRHLCNLLKETcaRSAEKTKKYEYEREETRQvymDLNNNIEKMILAFEELR----- 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  273 AQVSAQHLEVHLKQKEQHyeEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGK----ILSEQKAMINAMDSKIRSLE 348
Cdd:pfam05483  204 VQAENARLEMHFKLKEDH--EKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKdltfLLEESRDKANQLEEKTKLQD 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  349 QRIVELSEAN----------KLAANSSLFTQRNMKA---------------QEEMISELRQQKFY-------LETQAGKL 396
Cdd:pfam05483  282 ENLKELIEKKdhltkelediKMSLQRSMSTQKALEEdlqiatkticqlteeKEAQMEELNKAKAAhsfvvteFEATTCSL 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  397 EAQNRKLEEQLEKISHQ------DHSDKSRLLELETRL---REVSLEH------EEQKL------------ELKRQLTEL 449
Cdd:pfam05483  362 EELLRTEQQRLEKNEDQlkiitmELQKKSSELEEMTKFknnKEVELEElkkilaEDEKLldekkqfekiaeELKGKEQEL 441

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  450 QLSLQERES-------QLTALQAARAALESQLRQAKTELEETTAEAEEeiqaLTAHRDEIQRKFDALRNSCtviTDLEEQ 522
Cdd:pfam05483  442 IFLLQAREKeihdleiQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIE----LTAHCDKLLLENKELTQEA---SDMTLE 514

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  523 LNQLTEDnaeLNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL-----TSQKQAQLSAPDL----QTMEA 593
Cdd:pfam05483  515 LKKHQED---IINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVkckldKSEENARSIEYEVlkkeKQMKI 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  594 LKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQ---------SRARADQRITE- 663
Cdd:pfam05483  592 LENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQkfeeiidnyQKEIEDKKISEe 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  664 --------SRQVVELAVK---------EHK-AEILALQQALKEQ---------------KLKAESLSDKLNDLEKKHAML 710
Cdd:pfam05483  672 klleevekAKAIADEAVKlqkeidkrcQHKiAEMVALMEKHKHQydkiieerdselglyKNKEQEQSSAKAALEIELSNI 751

                          650       660
                   ....*....|....*....|....
gi 1039770408  711 EMNARSLQQKLETERELKQRLLEE 734
Cdd:pfam05483  752 KAELLSLKKQLEIEKEEKEKLKME 775
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 6-743 1.30e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 69.71  E-value: 1.30e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    6 EAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEddkalqllhdiRE 85
Cdd:TIGR02169  282 KDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEE-----------RK 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   86 QSRKLQEikeqEYQAQVEEMRLMMNQLEEDLVSARRRSDlyesELRESRLAAEEFKRKANECQHKLMKVVSHPPRGDSGG 165
Cdd:TIGR02169  351 RRDKLTE----EYAELKEELEDLRAELEEVDKEFAETRD----ELKDYREKLEKLKREINELKRELDRLQEELQRLSEEL 422

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  166 TALddlhkmqgHAGLTSAKDQgkpevgeYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEK 245
Cdd:TIGR02169  423 ADL--------NAAIAGIEAK-------INELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSK 487

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  246 LHNREDSSEGiKKKLVEAEELEEKHREAQVSAQHLEVH-----LKQKEQHYEEKIKV-----LDNQIKKDLADKESLENM 315
Cdd:TIGR02169  488 LQRELAEAEA-QARASEERVRGGRAVEEVLKASIQGVHgtvaqLGSVGERYATAIEVaagnrLNNVVVEDDAVAKEAIEL 566

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  316 MQRHE------------EEAHEKGKILSEQKAMINAMDskIRSLEQRIvelSEANKLAANSSLFTQRNMKAQEEMIselr 383
Cdd:TIGR02169  567 LKRRKagratflplnkmRDERRDLSILSEDGVIGFAVD--LVEFDPKY---EPAFKYVFGDTLVVEDIEAARRLMG---- 637

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  384 qqKFYLETQAGKLeaqnrkleeqLEKI-SHQDHSDKSRLLELETR-LREVSLEHEEQKLELKRQLTELQLSLQERESQLT 461
Cdd:TIGR02169  638 --KYRMVTLEGEL----------FEKSgAMTGGSRAPRGGILFSRsEPAELQRLRERLEGLKRELSSLQSELRRIENRLD 705

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  462 ALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDnaelnnqnfyls 541
Cdd:TIGR02169  706 ELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEED------------ 773

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  542 kqldeasgandeIVQLRSEVDHLRREITEREMQltsQKQAQlsapdlqtMEALKTTCTMLEEQVLDLEA-LNDELLEKEr 620
Cdd:TIGR02169  774 ------------LHKLEEALNDLEARLSHSRIP---EIQAE--------LSKLEEEVSRIEARLREIEQkLNRLTLEKE- 829

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  621 qweawrsvLGDEKSQfecrvRELQRMLDTEKQSRARADQritesrqvvelaVKEHKAEILALQQALKEQKLKAESLSDKL 700
Cdd:TIGR02169  830 --------YLEKEIQ-----ELQEQRIDLKEQIKSIEKE------------IENLNGKKEELEEELEELEAALRDLESRL 884

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*..
gi 1039770408  701 NDLEKKHAMLEMNARSLQQK---LETERE-LKQRLLEEQAKLQQQMD 743
Cdd:TIGR02169  885 GDLKKERDELEAQLRELERKieeLEAQIEkKRKRLSELKAKLEALEE 931
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 9-567 1.60e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.58  E-value: 1.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    9 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 88
Cdd:COG1196    279 LELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEA 358

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   89 KLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKvvshpprgdsggTAL 168
Cdd:COG1196    359 ELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEL------------EEL 426

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  169 DDLHKmqghAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHN 248
Cdd:COG1196    427 EEALA----ELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEAD 502

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  249 REDSSEGIKKKLVE----------AEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQR 318
Cdd:COG1196    503 YEGFLEGVKAALLLaglrglagavAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKI 582

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  319 HEEEAHEKGKILSEQKAMINAMDSKIRSLE---QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGK 395
Cdd:COG1196    583 RARAALAAALARGAIGAAVDLVASDLREADaryYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSL 662

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  396 LEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 475
Cdd:COG1196    663 TGGSRRELLAALLEAEAEL----EELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELL 738

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  476 QAKTELEETTAEAEEEIQALTAHRDEIQRKfdalrnsctvITDLEEQLNQL-------TEDNAELNNQNFYLSKQLDEAS 548
Cdd:COG1196    739 EELLEEEELLEEEALEELPEPPDLEELERE----------LERLEREIEALgpvnllaIEEYEELEERYDFLSEQREDLE 808

                          570
                   ....*....|....*....
gi 1039770408  549 GANDEIVQLRSEVDHLRRE 567
Cdd:COG1196    809 EARETLEEAIEEIDRETRE 827
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 607-877 3.24e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.42  E-value: 3.24e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  607 DLEALNDELLEKERQWEAwrsvLGDEKSQFEcRVRELQRMLDT-EKQSRARADQRITESRQVVELAVKEHKAEILALQQ- 684
Cdd:COG1196    187 NLERLEDILGELERQLEP----LERQAEKAE-RYRELKEELKElEAELLLLKLRELEAELEELEAELEELEAELEELEAe 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  685 ------ALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE 758
Cdd:COG1196    262 laeleaELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  759 ALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDpalptqvpLQYN 838
Cdd:COG1196    342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAE--------EALL 413

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1039770408  839 ELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 877
Cdd:COG1196    414 ERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA 452
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 18-575 3.41e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 68.61  E-value: 3.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   18 RRVSEVEAVLSQKEVELKAS----ETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEI 93
Cdd:pfam15921  317 RQLSDLESTVSQLRSELREAkrmyEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   94 KEQeyqaqveEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAeEFKRKANECQHKLMKVVshpprgdsggtalddlhk 173
Cdd:pfam15921  397 KEQ-------NKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEA-LLKAMKSECQGQMERQM------------------ 450

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  174 mqghagltsAKDQGKPEVGE-----YSKLEKINAEQQLKIQELQEK---LEKAVKASTEATELLQNIRQAKERAERELEK 245
Cdd:pfam15921  451 ---------AAIQGKNESLEkvsslTAQLESTKEMLRKVVEELTAKkmtLESSERTVSDLTASLQEKERAIEATNAEITK 521

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  246 LHNREDssegikKKLVEAEEL--EEKH-REAQVSAQHLEVHLKQKEQhyeeKIKVLDNQIkkdladkeslENMMQ---RH 319
Cdd:pfam15921  522 LRSRVD------LKLQELQHLknEGDHlRNVQTECEALKLQMAEKDK----VIEILRQQI----------ENMTQlvgQH 581

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  320 --------------EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSlftqRNMKAqeemISELRQ 384
Cdd:pfam15921  582 grtagamqvekaqlEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLElEKVKLVNAGS----ERLRA----VKDIKQ 653

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  385 QKFYLETQAGKLEAQNRKLEEQLEKishqdhsdksrlleLETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 464
Cdd:pfam15921  654 ERDQLLNEVKTSRNELNSLSEDYEV--------------LKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSME 719

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  465 AARA-ALESQLRQAKTeleettaeaeeeiqaLTAHRDEIqrkfDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQ 543
Cdd:pfam15921  720 GSDGhAMKVAMGMQKQ---------------ITAKRGQI----DALQSK---IQFLEEAMTNANKEKHFLKEEKNKLSQE 777

                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 1039770408  544 LD----EASGANDEIVQLRSEVDHLRREITEREMQL 575
Cdd:pfam15921  778 LStvatEKNKMAGELEVLRSQERRLKEKVANMEVAL 813
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 203-793 6.64e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 67.51  E-value: 6.64e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  203 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSsegikkkLVEAEE----LEEKHREAQVSAQ 278
Cdd:pfam01576    6 EMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETEL-------CAEAEEmrarLAARKQELEEILH 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  279 HLEVHLKQKEqhyeEKIKVLDNQIKKDLADKESLENmmQRHEEEAhekgkilSEQKAMIN--AMDSKIRSLEQRIVELSE 356
Cdd:pfam01576   79 ELESRLEEEE----ERSQQLQNEKKKMQQHIQDLEE--QLDEEEA-------ARQKLQLEkvTTEAKIKKLEEDILLLED 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  357 ANklaansslftqrnmkaqeemiSELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLR---EVSL 433
Cdd:pfam01576  146 QN---------------------SKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKkeeKGRQ 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  434 EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETtaeaeeeiqalTAHRDEIQRKfdalrnsc 513
Cdd:pfam01576  205 ELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEE-----------TAQKNNALKK-------- 265

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  514 tvITDLEEQLNQLTEDnaeLNNQNFYLSKQLDEASGANDEIVQLRSEV-DHLrrEITEREMQLTSQKQAQLSapdlQTME 592
Cdd:pfam01576  266 --IRELEAQISELQED---LESERAARNKAEKQRRDLGEELEALKTELeDTL--DTTAAQQELRSKREQEVT----ELKK 334

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  593 ALKTTCTMLEEQVLD--------LEALNDELLEKER---QWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQri 661
Cdd:pfam01576  335 ALEEETRSHEAQLQEmrqkhtqaLEELTEQLEQAKRnkaNLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEG-- 412

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  662 tesrQVVELAVKEHKAEILALQQALKEQKLKAE--SLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRllEEQAKLQ 739
Cdd:pfam01576  413 ----QLQELQARLSESERQRAELAEKLSKLQSEleSVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQE--ETRQKLN 486

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770408  740 -----QQMDLQKNhifrltqGLQEALDRADllkTERSDLEYQLENIQVLYSHEKVKMEG 793
Cdd:pfam01576  487 lstrlRQLEDERN-------SLQEQLEEEE---EAKRNVERQLSTLQAQLSDMKKKLEE 535
C1_ScPKC1-like_rpt2 cd20823
second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ...
 938-995 7.36e-11

second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410373  Cd Length: 59  Bit Score: 58.86  E-value: 7.36e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770408  938 HNIPHRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATCGLPAE 995
Cdd:cd20823      1 HRIPHRFEPFTNLGANWCCHCGQMLPLGRkQIRKCTECGKTAHAQCAHLVPNFCGLSME 59
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
403-872 8.14e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 66.99  E-value: 8.14e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  403 LEEQLEKISHQDHSDksRLLELETRLREVS--LEH-EEQKLELKRQLTELQLSLQERESQLTALQAARAALEsQLRQAKT 479
Cdd:PRK02224   192 LKAQIEEKEEKDLHE--RLNGLESELAELDeeIERyEEQREQARETRDEADEVLEEHEERREELETLEAEIE-DLRETIA 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  480 ELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTV----ITDLEEQLNQLTEDNAE----LNNQNFYLSKQLDEASGAN 551
Cdd:PRK02224   269 ETEREREELAEEVRDLRERLEELEEERDDLLAEAGLddadAEAVEARREELEDRDEElrdrLEECRVAAQAHNEEAESLR 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  552 DEIVQLRSEVDHLRREITEREMQLTSQKQA------QLSAPDLQtMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAW 625
Cdd:PRK02224   349 EDADDLEERAEELREEAAELESELEEAREAvedrreEIEELEEE-IEELRERFGDAPVDLGNAEDFLEELREERDELRER 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  626 RSVLGDEKSQFECRVRELQRMLDTEKQSRAraDQRITESRQVVELAVKEHKAEILALQqaLKEQKLKAESLSDKLN---- 701
Cdd:PRK02224   428 EAELEATLRTARERVEEAEALLEAGKCPEC--GQPVEGSPHVETIEEDRERVEELEAE--LEDLEEEVEEVEERLEraed 503

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  702 --DLEKKHAMLEMNARSLQQKLET-------ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSD 772
Cdd:PRK02224   504 lvEAEDRIERLEERREDLEELIAErretieeKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAE 583

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  773 LEYQLENIqvlyshekvkmeGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRkedpalptqvplqyNELKLALEKEKARCA 852
Cdd:PRK02224   584 LKERIESL------------ERIRTLLAAIADAEDEIERLREKREALAELN--------------DERRERLAEKRERKR 637

                          490       500
                   ....*....|....*....|.
gi 1039770408  853 ELEEALQKTRIE-LRSAREEA 872
Cdd:PRK02224   638 ELEAEFDEARIEeAREDKERA 658
PRK01156 PRK01156
chromosome segregation protein; Provisional
 30-589 9.47e-11

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 66.85  E-value: 9.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   30 KEV--ELKASETQRSLLEQDLATYITECSSLKRSLEQarmevsqeDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRL 107
Cdd:PRK01156   172 KDVidMLRAEISNIDYLEEKLKSSNLELENIKKQIAD--------DEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNE 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  108 MMNQLEEdlvsarrrSDLYESELR--ESRLAAEEFKR-KANECQHKLMKVVSHPprgdsggtALDDLHKMQGHAGLtsak 184
Cdd:PRK01156   244 LSSLEDM--------KNRYESEIKtaESDLSMELEKNnYYKELEERHMKIINDP--------VYKNRNYINDYFKY---- 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  185 dqgKPEVGEYSK-LEKINAEqqlkIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV-- 261
Cdd:PRK01156   304 ---KNDIENKKQiLSNIDAE----INKYHAIIKKL--------SVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNsy 368

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  262 --EAEELEEKHREAQVSAQHLEVHLKQKEQHYE---EKIKVLDNQIKKDLADKES-LENMMQR------HEEEAHEKGKI 329
Cdd:PRK01156   369 lkSIESLKKKIEEYSKNIERMSAFISEILKIQEidpDAIKKELNEINVKLQDISSkVSSLNQRiralreNLDELSRNMEM 448

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  330 LSEQKAM----INAMDSKIRSLEQRIVElsEANKLAANSSlFTQRNMKAQEEMISELRQQKFYLET-QAGKLEAQNRKLE 404
Cdd:PRK01156   449 LNGQSVCpvcgTTLGEEKSNHIINHYNE--KKSRLEEKIR-EIEIEVKDIDEKIVDLKKRKEYLESeEINKSINEYNKIE 525

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  405 E---QLEKISHQDHSDKSRLL---ELETRLREVSLEHEEQKL-----------------------ELKRQLTELQLSLQE 455
Cdd:PRK01156   526 SaraDLEDIKIKINELKDKHDkyeEIKNRYKSLKLEDLDSKRtswlnalavislidietnrsrsnEIKKQLNDLESRLQE 605

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  456 RESQLTALQAAraaLESQLRQAKTELEETTAEAEEeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNN 535
Cdd:PRK01156   606 IEIGFPDDKSY---IDKSIREIENEANNLNNKYNE-IQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIED 681

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770408  536 QNFYLSKQLDEA----SGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQ 589
Cdd:PRK01156   682 NLKKSRKALDDAkanrARLESTIEILRTRINELSDRINDINETLESMKKIKKAIGDLK 739
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 942-990 1.77e-10

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 57.48  E-value: 1.77e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1039770408   942 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 990
Cdd:smart00109    1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
C1 cd00029
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich ...
 942-990 1.85e-10

protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. It contains the motif HX12CX2CXnCX2CX4HX2CX7C, where C and H are cysteine and histidine, respectively; X represents other residues; and n is either 13 or 14. C1 has a globular fold with two separate Zn(2+)-binding sites. It was originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to phorbol esters (PE) and diacylglycerol (DAG) are referred to as typical, and those that do not respond to PE and DAG are deemed atypical. A C1 domain may also be referred to as PKC or non-PKC C1, based on the parent protein's activity. Most C1 domain-containing non-PKC proteins act as lipid kinases and scaffolds, except PKD which acts as a protein kinase. PKC C1 domains play roles in membrane translocation and activation of the enzyme.


Pssm-ID: 410341  Cd Length: 50  Bit Score: 57.53  E-value: 1.85e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039770408  942 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 990
Cdd:cd00029      1 HRFVPTTFSSPTFCDVCGKLIwGLFKQGLKCSDCGLVCHKKCLDKAPSPC 50
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 57-815 1.89e-10

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 66.13  E-value: 1.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   57 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRkLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE--LRESR 134
Cdd:COG3096    289 ELRRELFGARRQLAEEQYRLVEMARELEELSA-RESDLEQDYQAASDHLNLVQTALRQQEKIERYQEDLEELTerLEEQE 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  135 LAAEEFKRKANECQHKLMKVVSHPPRGDSG----GTALDDLHK-----MQGHAGLTSAKDQ-GKPE-----VGEYskLEK 199
Cdd:COG3096    368 EVVEEAAEQLAEAEARLEAAEEEVDSLKSQladyQQALDVQQTraiqyQQAVQALEKARALcGLPDltpenAEDY--LAA 445

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  200 INAEQQL---KIQELQEKLEKAVKASTE---ATELLQNIRQAKERAE---------RELEKLHNREDSSEGIKKKLVEAE 264
Cdd:COG3096    446 FRAKEQQateEVLELEQKLSVADAARRQfekAYELVCKIAGEVERSQawqtarellRRYRSQQALAQRLQQLRAQLAELE 525

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  265 ELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvLDNQikkdladKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 344
Cdd:COG3096    526 QRLRQQQNAERLLEEFCQRIGQQLDAAEE----LEEL-------LAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARI 594

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  345 RSLEQRivelsEANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISHQDHS 416
Cdd:COG3096    595 KELAAR-----APAWLAAQDALERLREQSGEAladsQEVTAAMQQLLEREREAtverDELAARKQALESQIERLSQPGGA 669

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  417 DKSRLLELETRLREV--SLEHEEQKLE-----------------------LKRQLTELQ-----LSLQER------ESQL 460
Cdd:COG3096    670 EDPRLLALAERLGGVllSEIYDDVTLEdapyfsalygparhaivvpdlsaVKEQLAGLEdcpedLYLIEGdpdsfdDSVF 749

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  461 TALQAARAAL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLtednaeln 534
Cdd:COG3096    750 DAEELEDAVVvklsDRQWRYSRFPEVPLfgRAAREKRLEELRAERDELAEQYAKASFDVQKLQRLHQAFSQF-------- 821

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  535 nqnfyLSKQLDEASGANDE--IVQLRSEVDHLRREITEREMQLTSQKQAQLSA-PDLQTMEALKTTCTMLEEQVL----- 606
Cdd:COG3096    822 -----VGGHLAVAFAPDPEaeLAALRQRRSELERELAQHRAQEQQLRQQLDQLkEQLQLLNKLLPQANLLADETLadrle 896

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  607 DLEALNDELLEKER----------QWEAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVELAVK 673
Cdd:COG3096    897 ELREELDAAQEAQAfiqqhgkalaQLEPLVAVLQSDPEQFE----QLQADYLQAKEQQRRLKQQIfalSEVVQRRPHFSY 972

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  674 EHKAEIL----ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHi 749
Cdd:COG3096    973 EDAVGLLgensDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELEQELEELGVQADA- 1051

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770408  750 frltqglqEALDRAdllKTERSDLEYQLeniqvlyshekVKMEGTISQQTKLIDFLQAKMDQPAKK 815
Cdd:COG3096   1052 --------EAEERA---RIRRDELHEEL-----------SQNRSRRSQLEKQLTRCEAEMDSLQKR 1095
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
312-548 2.15e-10

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 65.42  E-value: 2.15e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  312 LENMMQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSEANKLAAnsslfTQRNMKAQEEMISELRQQKFYLET 391
Cdd:COG3206    162 LEQNLELRREEARKALEFLEEQ---LPELRKELEEAEAALEEFRQKNGLVD-----LSEEAKLLLQQLSELESQLAEARA 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  392 QAGKLEAQNRKLEEQLEKISHQ--DHSDKSRLLELETRLREvsleheeqkleLKRQLTELQLSLQERESQLTALQAARAA 469
Cdd:COG3206    234 ELAEAEARLAALRAQLGSGPDAlpELLQSPVIQQLRAQLAE-----------LEAELAELSARYTPNHPDVIALRAQIAA 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  470 LESQLRQAkteLEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDnAELNNQNF-YLSKQLDEAS 548
Cdd:COG3206    303 LRAQLQQE---AQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLERE-VEVARELYeSLLQRLEEAR 378
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
5-472 2.18e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 65.86  E-value: 2.18e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLE--QDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHD 82
Cdd:PRK03918   246 ELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKelKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEING 325

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   83 IREQ-------SRKLQEIKEQEYQAQVEEMRL--------MMNQLEEDLVSARRRSDLYESELRESRLaaEEFKRKANEC 147
Cdd:PRK03918   326 IEERikeleekEERLEELKKKLKELEKRLEELeerhelyeEAKAKKEELERLKKRLTGLTPEKLEKEL--EELEKAKEEI 403

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  148 QHKLMKVVSHPPRGDSGG----TALDDLHKMQGHAGLTSAkdqgkpEVGEYSKLEkINAEQQLKIQELQEKLEKAVKAST 223
Cdd:PRK03918   404 EEEISKITARIGELKKEIkelkKAIEELKKAKGKCPVCGR------ELTEEHRKE-LLEEYTAELKRIEKELKEIEEKER 476

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  224 EATELLQNIRQAKERaERELEKLHNREDSSEGIKKKL--VEAEELEEKHREAQvsaqhlevHLKQKEQHYEEKIKVLdnq 301
Cdd:PRK03918   477 KLRKELRELEKVLKK-ESELIKLKELAEQLKELEEKLkkYNLEELEKKAEEYE--------KLKEKLIKLKGEIKSL--- 544

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  302 iKKDLADKESLENMMQRHEEEAHEKGKILSE-QKAMINAMDSKIRSLEQRIVELSEANK---LAANSSLFTQRNMKAQEE 377
Cdd:PRK03918   545 -KKELEKLEELKKKLAELEKKLDELEEELAElLKELEELGFESVEELEERLKELEPFYNeylELKDAEKELEREEKELKK 623

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  378 MISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKS-RLLELETRLREVslehEEQKLELKRQLTELQLSLQER 456
Cdd:PRK03918   624 LEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELReEYLELSRELAGL----RAELEELEKRREEIKKTLEKL 699

                          490
                   ....*....|....*.
gi 1039770408  457 ESQLTALQAARAALES 472
Cdd:PRK03918   700 KEELEEREKAKKELEK 715
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
370-774 2.32e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 65.17  E-value: 2.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  370 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKSRLLELETRLREVSlEHEEQKLELKRQLT 447
Cdd:COG4717     71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEElrEELEKLEKLLQLLPLYQELE-ALEAELAELPERLE 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  448 ELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLT 527
Cdd:COG4717    150 ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEE---LEEAQEELEELE 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  528 EDNAELNNQ--NFYLSKQLDEA-------------SGAND----------EIVQLRSEVDHLRREITEREMQLTSQKQAQ 582
Cdd:COG4717    227 EELEQLENEleAAALEERLKEArlllliaaallalLGLGGsllsliltiaGVLFLVLGLLALLFLLLAREKASLGKEAEE 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  583 LSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVL-----GDEKSQFECRVRELQRMLDTEK-QSRAR 656
Cdd:COG4717    307 LQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLreaeeLEEELQLEELEQEIAALLAEAGvEDEEE 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  657 ADQRITESRQVVELavkehKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLEEQA 736
Cdd:COG4717    387 LRAALEQAEEYQEL-----KEELEELEEQLEELLGELEELLEALDE-----EELEEELEELEEELEELEEELEELREELA 456

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1039770408  737 KLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLE 774
Cdd:COG4717    457 ELEAELEQLEE-----DGELAELLQELEELKAELRELA 489
PRK01156 PRK01156
chromosome segregation protein; Provisional
 244-746 2.33e-10

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 65.69  E-value: 2.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  244 EKLHNREDSSEGIKKKLveaEELEEKHREAQVSAQHLEVHLKQKEQHYeekikvldNQIKKDLADKESLENMMQRHEEEA 323
Cdd:PRK01156   190 EKLKSSNLELENIKKQI---ADDEKSHSITLKEIERLSIEYNNAMDDY--------NNLKSALNELSSLEDMKNRYESEI 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  324 HEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQeemISELRQQKFYLETQAGKLEAQNRKL 403
Cdd:PRK01156   259 KT----AESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKND---IENKKQILSNIDAEINKYHAIIKKL 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  404 EEqLEKISHQDHSDKSRLLELETRLREVSLEH-----------------EEQKLELKRQLTELQLSLQERESQLTALQAA 466
Cdd:PRK01156   332 SV-LQKDYNDYIKKKSRYDDLNNQILELEGYEmdynsylksieslkkkiEEYSKNIERMSAFISEILKIQEIDPDAIKKE 410

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  467 RAALESQLRQakteLEETTAEAEEEIQALTAHRDEIQRKFDAL--RNSCTVI-TDL-EEQLNQLTED-NAELNNQNFYLS 541
Cdd:PRK01156   411 LNEINVKLQD----ISSKVSSLNQRIRALRENLDELSRNMEMLngQSVCPVCgTTLgEEKSNHIINHyNEKKSRLEEKIR 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  542 KQLDEASGANDEIVQLRSEVDHL------------------RREITEREMQLTSQKQAQLSAP---------DLQTMEAL 594
Cdd:PRK01156   487 EIEIEVKDIDEKIVDLKKRKEYLeseeinksineynkiesaRADLEDIKIKINELKDKHDKYEeiknrykslKLEDLDSK 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  595 KTTCTMLEEQV--LDLEALNDELLEKERQWEAWRSVLG-------DEKSQFECRVRELQRMLDT--EKQSRARADQRITE 663
Cdd:PRK01156   567 RTSWLNALAVIslIDIETNRSRSNEIKKQLNDLESRLQeieigfpDDKSYIDKSIREIENEANNlnNKYNEIQENKILIE 646

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  664 SRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKLQ 739
Cdd:PRK01156   647 KLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRtrinELSDRINDINETLE 726


                   ....*..
gi 1039770408  740 QQMDLQK 746
Cdd:PRK01156   727 SMKKIKK 733
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 13-756 3.28e-10

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 65.38  E-value: 3.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   13 MTRLHRRVSEVEAVLSQKEVELkasETQrsLLEQDLATYITECSSLKRSLEQARMEVSQE---DDKALQLLHDIREQSRK 89
Cdd:TIGR00618  184 MEFAKKKSLHGKAELLTLRSQL---LTL--CTPCMPDTYHERKQVLEKELKHLREALQQTqqsHAYLTQKREAQEEQLKK 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   90 LQEIKE---QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPPrgdsggT 166
Cdd:TIGR00618  259 QQLLKQlraRIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRA------A 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  167 ALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL 246
Cdd:TIGR00618  333 HVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATI 412

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  247 HNREDSSEGIKKKLVEAE---ELEEKHREA-QVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKdLADKEsleNMMQRHEEE 322
Cdd:TIGR00618  413 DTRTSAFRDLQGQLAHAKkqqELQQRYAELcAAAITCTAQCEKLEKIHLQESAQSLKEREQQ-LQTKE---QIHLQETRK 488

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  323 AHEKGKILSEQKaminamdSKIRSLEQRIVELSEANKLAANSSLFTQRnmkaqeemISELRQQKFYLETQAGKLEAQNRK 402
Cdd:TIGR00618  489 KAVVLARLLELQ-------EEPCPLCGSCIHPNPARQDIDNPGPLTRR--------MQRGEQTYAQLETSEEDVYHQLTS 553

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  403 LEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 482
Cdd:TIGR00618  554 ERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLH 633

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  483 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQL---NQLTEDNAE-LNNQNFYLSKQLDEASGANDEIVQLR 558
Cdd:TIGR00618  634 LQQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKELlasRQLALQKMQsEKEQLTYWKEMLAQCQTLLRELETHI 713

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  559 SEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERqweawrsvLGDEKSQFEC 638
Cdd:TIGR00618  714 EEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQ--------TGAELSHLAA 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  639 RVRELQRMLDTEKQSRARADQRITESRQVVELAVKehkAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ 718
Cdd:TIGR00618  786 EIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILN---LQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLA 862

                          730       740       750
                   ....*....|....*....|....*....|....*...
gi 1039770408  719 QKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGL 756
Cdd:TIGR00618  863 QLTQEQAKIIQLSDKLNGINQIKIQFDGDALIKFLHEI 900
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
193-755 6.92e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 63.63  E-value: 6.92e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELeklhnredssegikkklveaEELEEKHRE 272
Cdd:COG4717     54 EADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEEL--------------------EELEAELEE 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  273 AQVSAQHLEvHLKQKEQHYEEKIKVldnqikkdladKESLENMMQRHEEeahekgkiLSEQKAMINAMDSKIRSLEQRIV 352
Cdd:COG4717    114 LREELEKLE-KLLQLLPLYQELEAL-----------EAELAELPERLEE--------LEERLEELRELEEELEELEAELA 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  353 ELSEA-NKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS--HQDHSDKSRLLELETRLR 429
Cdd:COG4717    174 ELQEElEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLEneLEAAALEERLKEARLLLL 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  430 EVSLEHEeqklelkrqLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDAL 509
Cdd:COG4717    254 IAAALLA---------LLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEEL 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  510 RNSCTVITDLEEqlnqltednaelnnqnfylsKQLDEASGANDEIVQLRSEVDHLRREIteREMQLTSQKQAQLSAPDLQ 589
Cdd:COG4717    325 LAALGLPPDLSP--------------------EELLELLDRIEELQELLREAEELEEEL--QLEELEQEIAALLAEAGVE 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  590 TMEALKTTCTMLEEQV---LDLEALNDELLEKERQWEAWRSVLGDEksqfecrvrELQRMLDTEKQSRARADQRITESRQ 666
Cdd:COG4717    383 DEEELRAALEQAEEYQelkEELEELEEQLEELLGELEELLEALDEE---------ELEEELEELEEELEELEEELEELRE 453

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  667 vvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAklqqqmdlqk 746
Cdd:COG4717    454 --ELAELEAELEQLEEDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPVLERA---------- 521

                          570
                   ....*....|
gi 1039770408  747 NHIF-RLTQG 755
Cdd:COG4717    522 SEYFsRLTDG 531
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
321-779 7.43e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 64.17  E-value: 7.43e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  321 EEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 397
Cdd:COG4913    238 ERAHEALEDAREQIELlepIRELAERYAAARERLAELEYL--RAALRLWFAQRRLELLEAELEELRAELARLEAELERLE 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  398 AQNRKLEEQLEKISHQ-DHSDKSRLLELETRLREVSLEHEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQ 473
Cdd:COG4913    316 ARLDALREELDELEAQiRGNGGDRLEQLEREIERLERELEERErrrARLEALLAALGLPLPASAEEFAALRAEAAALLEA 395

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  474 LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI--------TDLEEQLN-------------QLTEDNAE 532
Cdd:COG4913    396 LEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIparllalrDALAEALGldeaelpfvgeliEVRPEEER 475

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  533 --------LNNQNFYL---SKQLDEASGANDEIvqlrsevdHLRREITEREMQLTSQKQAQLSAPD---LQTMEALKTTC 598
Cdd:COG4913    476 wrgaiervLGGFALTLlvpPEHYAAALRWVNRL--------HLRGRLVYERVRTGLPDPERPRLDPdslAGKLDFKPHPF 547

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  599 TM-LEEQ---------VLDLEALNDE---------------LLEKERQWEAWRS-VLG----DEKSQFECRVRELQRMLD 648
Cdd:COG4913    548 RAwLEAElgrrfdyvcVDSPEELRRHpraitragqvkgngtRHEKDDRRRIRSRyVLGfdnrAKLAALEAELAELEEELA 627

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  649 T--EKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEqklkAESLSDKLNDLEKKHAMLemnaRSLQQKLETERE 726
Cdd:COG4913    628 EaeERLEALEAELDALQERREALQRLAEYSWDEIDVASAERE----IAELEAELERLDASSDDL----AALEEQLEELEA 699

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039770408  727 LKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRAD-LLKTERSDLEYQLEN 779
Cdd:COG4913    700 ELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEaAEDLARLELRALLEE 753
PTZ00121 PTZ00121
MAEBL; Provisional
 181-879 1.24e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 63.62  E-value: 1.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  181 TSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKAsteatellQNIRQAKErAERELEKLHNREDSSEGIKKKL 260
Cdd:PTZ00121  1090 DEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKA--------EEARKAED-ARKAEEARKAEDAKRVEIARKA 1160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  261 VEAEELEEKHREAQvsAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQ--RHEEEAHEKGKILSEQKAMIN 338
Cdd:PTZ00121  1161 EDARKAEEARKAED--AKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEeaRKAEDAKKAEAVKKAEEAKKD 1238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  339 AMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEE-MISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSD 417
Cdd:PTZ00121  1239 AEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEArKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKAD 1318

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  418 KSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA 497
Cdd:PTZ00121  1319 EAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKK 1398

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  498 HRDEIQRKFDALRNSCTVITDLEEqlnqlTEDNAELNNQNFYLSKQLDEASGANDeiVQLRSEVDHLRREITEREMQLTS 577
Cdd:PTZ00121  1399 KAEEDKKKADELKKAAAAKKKADE-----AKKKAEEKKKADEAKKKAEEAKKADE--AKKKAEEAKKAEEAKKKAEEAKK 1471

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  578 QKQAQLSAPDLQTMEALKTTCtmlEEQVLDLEALNDELLEKERQWEAWRSvlgDEKSQFEcRVRELQRMLDTEKQSRARA 657
Cdd:PTZ00121  1472 ADEAKKKAEEAKKADEAKKKA---EEAKKKADEAKKAAEAKKKADEAKKA---EEAKKAD-EAKKAEEAKKADEAKKAEE 1544

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  658 DQRITESRQVVELAVKEHKAEILALQQAlKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAK 737
Cdd:PTZ00121  1545 KKKADELKKAEELKKAEEKKKAEEAKKA-EEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAE 1623

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  738 LQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEgtisqqtklidflQAKMDQPAKKKK 817
Cdd:PTZ00121  1624 ELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAE-------------EAKKAEEDEKKA 1690

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039770408  818 GLFSRRKEDPALPTQvplqynELKLALEKEKARCAEL--EEALQKTRIELRSAREEAAHRKATD 879
Cdd:PTZ00121  1691 AEALKKEAEEAKKAE------ELKKKEAEEKKKAEELkkAEEENKIKAEEAKKEAEEDKKKAEE 1748
mukB PRK04863
chromosome partition protein MukB;
81-781 1.38e-09

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 63.44  E-value: 1.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   81 HDIREQSRKLQEIK------EQEYQAQVEEMRLMMNQL---------EEDLVSARRRsdLYES-----ELRESRLAAEEF 140
Cdd:PRK04863   307 YRLVEMARELAELNeaesdlEQDYQAASDHLNLVQTALrqqekieryQADLEELEER--LEEQnevveEADEQQEENEAR 384

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  141 KRKANECQHKLMKVVSHPPRgdsggtALDDLHKM-----QGHAGLTSAKDQ-GKPEVgEYSKLEKINAEQQLKIQELQEK 214
Cdd:PRK04863   385 AEAAEEEVDELKSQLADYQQ------ALDVQQTRaiqyqQAVQALERAKQLcGLPDL-TADNAEDWLEEFQAKEQEATEE 457

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  215 L----------EKAVKASTEATELLQNI----------RQAKErAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQ 274
Cdd:PRK04863   458 LlsleqklsvaQAAHSQFEQAYQLVRKIagevsrseawDVARE-LLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQRAE 536

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  275 vsaQHLEVHLKQKEQHYEEKIKVLDNQikkdladkESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVEL 354
Cdd:PRK04863   537 ---RLLAEFCKRLGKNLDDEDELEQLQ--------EELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARAPAW 605

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  355 seankLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISHQDHSDKSRLLELET 426
Cdd:PRK04863   606 -----LAAQDALARLREQSGEEfedsQDVTEYMQQLLERERELtverDELAARKQALDEEIERLSQPGGSEDPRLNALAE 680

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  427 RLREVSLE--HEEQKLE-----------------------LKRQLTELQ-----LSLQE------RESQLTALQAARAAL 470
Cdd:PRK04863   681 RFGGVLLSeiYDDVSLEdapyfsalygparhaivvpdlsdAAEQLAGLEdcpedLYLIEgdpdsfDDSVFSVEELEKAVV 760

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  471 ----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTednaelnNQNFYLSKQL 544
Cdd:PRK04863   761 vkiaDRQWRYSRFPEVPLfgRAAREKRIEQLRAEREELAERYATLSFDVQKLQRLHQAFSRFI-------GSHLAVAFEA 833

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  545 DEasgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAqlsapdlqtMEALKTTCTMLEE-----QVLDLEALNDELLEKE 619
Cdd:PRK04863   834 DP----EAELRQLNRRRVELERALADHESQEQQQRSQ---------LEQAKEGLSALNRllprlNLLADETLADRVEEIR 900

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  620 RQWEAWR--------------------SVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHK 676
Cdd:PRK04863   901 EQLDEAEeakrfvqqhgnalaqlepivSVLQSDPEQFE----QLKQDYQQAQQTQRDAKQQAfalTEVVQRRAHFSYEDA 976

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  677 AEILA----LQQALKEQKLKAESLSDKLNDLEKKHA--MLEMNAR------SLQQKLETERELKQRL----------LEE 734
Cdd:PRK04863   977 AEMLAknsdLNEKLRQRLEQAEQERTRAREQLRQAQaqLAQYNQVlaslksSYDAKRQMLQELKQELqdlgvpadsgAEE 1056

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*..
gi 1039770408  735 QAKLQQQmdlqknhifRLTQGLQEALDRADLLKTERSDLEYQLENIQ 781
Cdd:PRK04863  1057 RARARRD---------ELHARLSANRSRRNQLEKQLTFCEAEMDNLT 1094
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1195-1446 1.75e-09

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 62.99  E-value: 1.75e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1195 SDQVVLVGTEEGLYALNVLKNS--------LTHIPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1266
Cdd:COG5422    868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1267 aqpDVSPNIFEAVK-----GCHLFAAGKiENSLCICAAMPSKVVILRYNDN------LSKYCIRKEIETSEPCScIHFTN 1335
Cdd:COG5422    944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNKSgnlkkaLTIELSTELYVPSEPLS-VHFLK 1018

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1336 YSILIGTNKFYEI-DMKQYTLDEFLDKNDHSlaPAVFASSSNSFPVSIVQANSagqreEYLLCFHEFGVFVDSYGRRSRT 1414
Cdd:COG5422   1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1039770408 1415 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1446
Cdd:COG5422   1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
192-739 2.38e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 62.36  E-value: 2.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  192 GEYSKLekINA---EQQ------LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEK-----LHNREDSSEGIK 257
Cdd:PRK02224   138 GEVNKL--INAtpsDRQdmiddlLQLGKLEEYRERASDARLGVERVLSDQRGSLDQLKAQIEEkeekdLHERLNGLESEL 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  258 KKL-VEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEkIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAM 336
Cdd:PRK02224   216 AELdEEIERYEEQREQARETRDEADEVLEEHEERREE-LETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEE 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  337 INAM-------DSKIRSLEQRIVELsEANKLAANSSLFTQR-NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLE 408
Cdd:PRK02224   295 RDDLlaeagldDADAEAVEARREEL-EDRDEELRDRLEECRvAAQAHNEEAESLREDADDLEERAEELREEAAELESELE 373

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  409 KISHQDHSDKSRLLELETRLRE---------VSLEHEEQKLELKRQ-LTELQLSLQERESQLTALQAARAALESQLRQAK 478
Cdd:PRK02224   374 EAREAVEDRREEIEELEEEIEElrerfgdapVDLGNAEDFLEELREeRDELREREAELEATLRTARERVEEAEALLEAGK 453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  479 TELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQL-----TEDNAE-LNNQNFYLSKQLDEASGAND 552
Cdd:PRK02224   454 CPECGQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAedlveAEDRIErLEERREDLEELIAERRETIE 533

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  553 E----IVQLRSEVDHLRREITEREMQLTSQK-QAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRS 627
Cdd:PRK02224   534 EkrerAEELRERAAELEAEAEEKREAAAEAEeEAEEAREEVAELNSKLAELKERIESLERIRTLLAAIADAEDEIERLRE 613

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  628 vlgdeksqfecRVRELQRMldtEKQSRARADQRITESRqvvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKH 707
Cdd:PRK02224   614 -----------KREALAEL---NDERRERLAEKRERKR---ELEAEFDEARIEEAREDKERAEEYLEQVEEKLDELREER 676

                          570       580       590
                   ....*....|....*....|....*....|..
gi 1039770408  708 AMLEMNARSLQQKLETERELKQRLLEEQAKLQ 739
Cdd:PRK02224   677 DDLQAEIGAVENELEELEELRERREALENRVE 708
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
403-872 2.43e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 62.09  E-value: 2.43e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  403 LEEQLEKISHQDHSDKSRLLELE-TRLREVSLEHEEQKlELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 481
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNlKELKELEEELKEAE-EKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  482 EETTAEAEeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ------------NFYLSKQLDEASG 549
Cdd:COG4717    126 QLLPLYQE--LEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEEleelleqlslatEEELQDLAEELEE 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  550 ANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTcTMLEEQVLDLEALNDELLEKERQWEAWRSVL 629
Cdd:COG4717    204 LQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLL-LLIAAALLALLGLGGSLLSLILTIAGVLFLV 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  630 GdeksqfecrvrelqRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKham 709
Cdd:COG4717    283 L--------------GLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDR--- 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  710 lemnARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHI-----FRltqGLQEALDRADLLKTERSDLEYQLENI---- 780
Cdd:COG4717    346 ----IEELQELLREAEELEEELQLEELEQEIAALLAEAGVedeeeLR---AALEQAEEYQELKEELEELEEQLEELlgel 418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  781 -QVLYSHEKVKMEGTISQQTKLIDFLQAKMDQpAKKKKGLFSRRKEDpaLPTQVPLQynELKLALEKEKARCAELEE--- 856
Cdd:COG4717    419 eELLEALDEEELEEELEELEEELEELEEELEE-LREELAELEAELEQ--LEEDGELA--ELLQELEELKAELRELAEewa 493

                          490
                   ....*....|....*.
gi 1039770408  857 ALQKTRIELRSAREEA 872
Cdd:COG4717    494 ALKLALELLEEAREEY 509
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 229-782 2.75e-09

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 62.16  E-value: 2.75e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  229 LQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQ-HLEVHLKQKEQHYEEKI-------KVLDN 300
Cdd:pfam12128  236 IMKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSaELNQLLRTLDDQWKEKRdelngelSAADA 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  301 QIKKDLADKESLENMMQRHEEEAHEKGKI-----------LSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLftQ 369
Cdd:pfam12128  316 AVAKDRSELEALEDQHGAFLDADIETAAAdqeqlpswqseLENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNRDI--A 393

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  370 RNMKAQEEMISELRQQKFYLETQAGKLEAQ-NRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEqklelKRQLTE 448
Cdd:pfam12128  394 GIKDKLAKIREARDRQLAVAEDDLQALESElREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPEL-----LLQLEN 468

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  449 LQLSLQERESQLTALQAARAALESQLRQAKTELEettaeaeeeiQALTAHRDEIQRkfdalrnsctvitdLEEQLNQLTE 528
Cdd:pfam12128  469 FDERIERAREEQEAANAEVERLQSELRQARKRRD----------QASEALRQASRR--------------LEERQSALDE 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  529 dnaelnnqnfyLSKQLDEASGANDEIvqLRSEV----DHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQ 604
Cdd:pfam12128  525 -----------LELQLFPQAGTLLHF--LRKEApdweQSIGKVISPELLHRTDLDPEVWDGSVGGELNLYGVKLDLKRID 591

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  605 VLDLEALNDELLEKERQWEawrSVLGDEKS---QFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILA 681
Cdd:pfam12128  592 VPEWAASEEELRERLDKAE---EALQSAREkqaAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDK 668

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  682 LQQALKEQKLKAE----SLSDKLNDLEKKH-AMLEMNARSLQ----QKLETERELKQRLLEEQAKLQQQMDLQKNHIFRL 752
Cdd:pfam12128  669 KNKALAERKDSANerlnSLEAQLKQLDKKHqAWLEEQKEQKReartEKQAYWQVVEGALDAQLALLKAAIAARRSGAKAE 748

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|..
gi 1039770408  753 TQGLQEALDRaDL------------LKTERSDLEYQLENIQV 782
Cdd:pfam12128  749 LKALETWYKR-DLaslgvdpdviakLKREIRTLERKIERIAV 789
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 202-579 3.43e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 62.01  E-value: 3.43e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  202 AEQQLKIQELQEKLEKAVKasteateLLQNIRQAKERAEREL-EKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHL 280
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKR-------ELSSLQSELRRIENRLdELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEEL 742

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  281 EVHLKQKEQHYEEKIKVLDnQIKKDLADKESLENMMQRHEE--EAHEKGKILSEQKAMINAMDSKIRSLEQRIVELsean 358
Cdd:TIGR02169  743 EEDLSSLEQEIENVKSELK-ELEARIEELEEDLHKLEEALNdlEARLSHSRIPEIQAELSKLEEEVSRIEARLREI---- 817

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  359 klaansslftqrnmkaqEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKSRLLELETRLREvsleheeq 438
Cdd:TIGR02169  818 -----------------EQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSI-------EKEIENLNGKKEE-------- 865

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  439 kleLKRQLTELQLSLQERESQLTALQAARAALESQLRQAKT----------ELEETTAEAEEEIQALTAHRDEIQRKFDA 508
Cdd:TIGR02169  866 ---LEEELEELEAALRDLESRLGDLKKERDELEAQLRELERkieeleaqieKKRKRLSELKAKLEALEEELSEIEDPKGE 942

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039770408  509 LRNSCT---VITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQK 579
Cdd:TIGR02169  943 DEEIPEeelSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEKKK 1016
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
203-666 3.65e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 61.85  E-value: 3.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  203 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAE--ELEEKHREAQVSAQHL 280
Cdd:COG4913    285 FAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLEREieRLERELEERERRRARL 364

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  281 EVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSeANKL 360
Cdd:COG4913    365 EALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIP-ARLL 443

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  361 AANSSLFTQRNMKAQE--------EMISE-----------LRQQKF--------------------------YLETQAGK 395
Cdd:COG4913    444 ALRDALAEALGLDEAElpfvgeliEVRPEeerwrgaiervLGGFALtllvppehyaaalrwvnrlhlrgrlvYERVRTGL 523

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  396 LEAQNRKLEEQ--LEKISHQDHSDKSRLL-ELETRLREVSLEHEEQKLELKRQLT-ELQLSL------------------ 453
Cdd:COG4913    524 PDPERPRLDPDslAGKLDFKPHPFRAWLEaELGRRFDYVCVDSPEELRRHPRAITrAGQVKGngtrhekddrrrirsryv 603

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  454 --QERESQLTALQAARAALESQLRQAKteleettaeaeEEIQALTAHRDEIQRKFDALRNSCTV-------------ITD 518
Cdd:COG4913    604 lgFDNRAKLAALEAELAELEEELAEAE-----------ERLEALEAELDALQERREALQRLAEYswdeidvasaereIAE 672

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  519 LEEQLNQLTEDNAELNNqnfyLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQLTS-QKQAQLSAPDLQTMEALKTt 597
Cdd:COG4913    673 LEAELERLDASSDDLAA----LEEQLEE---LEAELEELEEELDELKGEIGRLEKELEQaEEELDELQDRLEAAEDLAR- 744

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770408  598 ctmlEEQVLDLEALNDELLEKERQWEAwrsvlgdeksqfecrVRELQRMLDTEKQSRARADQRITESRQ 666
Cdd:COG4913    745 ----LELRALLEERFAAALGDAVEREL---------------RENLEERIDALRARLNRAEEELERAMR 794
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 9-594 3.95e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 61.52  E-value: 3.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    9 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQ---RSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIRE 85
Cdd:TIGR00618  384 LQQQKTTLTQKLQSLCKELDILQREQATIDTRtsaFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQE 463

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   86 QSRKLQEIKEQEYQAQVeemrlmmnqleedlvsarrrsdlyeSELRESRLAAEEFKR----KANECQHKLMKVVSHPPRG 161
Cdd:TIGR00618  464 SAQSLKEREQQLQTKEQ-------------------------IHLQETRKKAVVLARllelQEEPCPLCGSCIHPNPARQ 518

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  162 DSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAER 241
Cdd:TIGR00618  519 DIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQD 598

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  242 ELEKLHNREDssegikkKLVEAEELEEKHREAQVSAQHLEVHLKQKEQhyeekikvldNQIKKDLADKESLENMMQRHEE 321
Cdd:TIGR00618  599 LTEKLSEAED-------MLACEQHALLRKLQPEQDLQDVRLHLQQCSQ----------ELALKLTALHALQLTLTQERVR 661

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  322 EAHEKGKILSEQKAMIN-----AMDSKIRSLEQRIVELSEANKLaansslftqrnMKAQEEMISELR----QQKFYLETQ 392
Cdd:TIGR00618  662 EHALSIRVLPKELLASRqlalqKMQSEKEQLTYWKEMLAQCQTL-----------LRELETHIEEYDrefnEIENASSSL 730

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  393 AGKLEAQNRKLEEQLEKISHQdhsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 472
Cdd:TIGR00618  731 GSDLAAREDALNQSLKELMHQ----ARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEA 806

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  473 QLRQAKTELEETTAEAEEEIQaltAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND 552
Cdd:TIGR00618  807 EIGQEIPSDEDILNLQCETLV---QEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQ 883

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770408  553 EIVQLRSEV----------DHLRREITEREMQLTSQKQAQLSAPDLQTMEAL 594
Cdd:TIGR00618  884 IKIQFDGDAlikflheitlYANVRLANQSEGRFHGRYADSHVNARKYQGLAL 935
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 192-892 8.17e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 60.75  E-value: 8.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  192 GEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIR--QAKERAERELEKLHNREDSSEGIKKKLVEAEELEEK 269
Cdd:TIGR00618  152 GEFAQFLKAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHgkAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHL 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  270 hREAQVSAQHLEVHLKQKEQHYEEKIKvLDNQIKKDLADKESLENMMQRHEEE------AHEKGKILSEQKAMINaMDSK 343
Cdd:TIGR00618  232 -REALQQTQQSHAYLTQKREAQEEQLK-KQQLLKQLRARIEELRAQEAVLEETqerinrARKAAPLAAHIKAVTQ-IEQQ 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  344 IRSLEQRIVElseanKLAANSSLFTQRNMKAQEEmiSELRQQKFYLETqagkLEAQNRKLEEQLEK-ISHQDHSDKSRLL 422
Cdd:TIGR00618  309 AQRIHTELQS-----KMRSRAKLLMKRAAHVKQQ--SSIEEQRRLLQT----LHSQEIHIRDAHEVaTSIREISCQQHTL 377

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  423 ELETRLREVSLEHEEQKLEL----KRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAH 498
Cdd:TIGR00618  378 TQHIHTLQQQKTTLTQKLQSlckeLDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLE 457

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  499 RDEIQRKFDALRNSctviTDLEEQLNQLTEDNAElnnqnfylSKQLDEasgandeivQLRSEVDHLRREITEREMQLTSQ 578
Cdd:TIGR00618  458 KIHLQESAQSLKER----EQQLQTKEQIHLQETR--------KKAVVL---------ARLLELQEEPCPLCGSCIHPNPA 516

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  579 K-QAQLSAPDLQTMEALKTTCTMLEEQVLDLEAlndellekerqweawrsvlgdeksqfecrvrelqrMLDTEKQSRARA 657
Cdd:TIGR00618  517 RqDIDNPGPLTRRMQRGEQTYAQLETSEEDVYH-----------------------------------QLTSERKQRASL 561

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  658 DQRITESRQvvelavkehkaEILALQQALKEQKLKAESLSDKLNDLEKkhaMLEMNARSLQQKLETERELKQRLLEEQAK 737
Cdd:TIGR00618  562 KEQMQEIQQ-----------SFSILTQCDNRSKEDIPNLQNITVRLQD---LTEKLSEAEDMLACEQHALLRKLQPEQDL 627

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  738 LQQQMDLQKnhifrLTQGLQEALDRadlLKTERSDLEYQLENIQVLYSHEKVKMEGTISQqtKLIDFLQAKMDQPAKKKK 817
Cdd:TIGR00618  628 QDVRLHLQQ-----CSQELALKLTA---LHALQLTLTQERVREHALSIRVLPKELLASRQ--LALQKMQSEKEQLTYWKE 697

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770408  818 GL----FSRRKEDPALPTQVPlQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQ 892
Cdd:TIGR00618  698 MLaqcqTLLRELETHIEEYDR-EFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQ 775
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 301-779 1.07e-08

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 60.14  E-value: 1.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  301 QIKKDLADKEsLENMMQRHEEE--AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkaqeEM 378
Cdd:pfam05557   13 QLQNEKKQME-LEHKRARIELEkkASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALR-----------------EQ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  379 ISELRQQKFYLETQAGKLEAQnrklEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLE---LKRQLTELQLSLQE 455
Cdd:pfam05557   75 AELNRLKKKYLEALNKKLNEK----ESQLADAREVISCLKNELSELRRQIQRAELELQSTNSEleeLQERLDLLKAKASE 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  456 RE---SQLTALQAARAALESQLR--QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNQLTEDN 530
Cdd:pfam05557  151 AEqlrQNLEKQQSSLAEAEQRIKelEFEIQSQEQDSEIVKNSKSELARIPELEKELERLR-------EHNKHLNENIENK 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  531 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREmqltsqKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEA 610
Cdd:pfam05557  224 LLLKEEVEDLKRKLEREEKYREEAATLELEKEKLEQELQSWV------KLAQDTGLNLRSPEDLSRRIEQLQQREIVLKE 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  611 LNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEiLALQQALK 687
Cdd:pfam05557  298 ENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVlllTKERDGYRAILESYDKE-LTMSNYSP 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  688 EQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ-----KNHIFRLTQGLQEALDR 762
Cdd:pfam05557  377 QLLERIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLAdpsysKEEVDSLRRKLETLELE 456

                          490
                   ....*....|....*..
gi 1039770408  763 ADLLKTERSDLEYQLEN 779
Cdd:pfam05557  457 RQRLREQKNELEMELER 473
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 22-743 1.84e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 59.42  E-value: 1.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   22 EVEAVLSQKEVELKASETQ---RSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR-------KLQ 91
Cdd:pfam01576  300 ELEALKTELEDTLDTTAAQqelRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKrnkanleKAK 379

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   92 EIKEQEYQAQVEEMRLMMNQLEEdlvSARRRSDLyESELRESRLAAEEFKRKANECQHKLMKVVSHPprgDSGGTALDDL 171
Cdd:pfam01576  380 QALESENAELQAELRTLQQAKQD---SEHKRKKL-EGQLQELQARLSESERQRAELAEKLSKLQSEL---ESVSSLLNEA 452

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  172 ----HKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQE-----LQEKLEKAVKASTEATELLQNIRQAKERAERE 242
Cdd:pfam01576  453 egknIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEdernsLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKK 532

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  243 LEKLHNREDSSEGIKKKLV-EAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQ-------------IKKDLAD 308
Cdd:pfam01576  533 LEEDAGTLEALEEGKKRLQrELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQrqlvsnlekkqkkFDQMLAE 612

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  309 KESLENMMQ----RHEEEAHEK-GKILSEQKAMINAMDSKirsleqriVELSEANKLaansslftqrnMKAQ-EEMIS-- 380
Cdd:pfam01576  613 EKAISARYAeerdRAEAEAREKeTRALSLARALEEALEAK--------EELERTNKQ-----------LRAEmEDLVSsk 673

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  381 --------ELRQQKFYLETQAGKLEAQNRKLEEQLekishQDHSDKSRLLELETRLREVSLEH---------EEQKLELK 443
Cdd:pfam01576  674 ddvgknvhELERSKRALEQQVEEMKTQLEELEDEL-----QATEDAKLRLEVNMQALKAQFERdlqardeqgEEKRRQLV 748

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  444 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQAL---TAHRDEIQRKFDALRNSCTVI---- 516
Cdd:pfam01576  749 KQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLkklQAQMKDLQRELEEARASRDEIlaqs 828

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  517 -------TDLEEQLNQLTEDNA------------------ELNNQNFYLSKQLDEASGANDEIVQLRSEvdhLRREITER 571
Cdd:pfam01576  829 kesekklKNLEAELLQLQEDLAaserarrqaqqerdeladEIASGASGKSALQDEKRRLEARIAQLEEE---LEEEQSNT 905

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  572 EMQLTSQKQAQLSAPDLQT-MEALKTTCTMLEEQVLDLEALNDELLEKERQWE-AWRSVLGDEKSQFECRVRELQRMLDT 649
Cdd:pfam01576  906 ELLNDRLRKSTLQVEQLTTeLAAERSTSQKSESARQQLERQNKELKAKLQEMEgTVKSKFKSSIAALEAKIAQLEEQLEQ 985

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  650 EKQSRARADQRITEsrqvvelavKEHKAEILALQqaLKEQKLKAESLSDKLndlEKKHAMLemnaRSLQQKLETERELKQ 729
Cdd:pfam01576  986 ESRERQAANKLVRR---------TEKKLKEVLLQ--VEDERRHADQYKDQA---EKGNSRM----KQLKRQLEEAEEEAS 1047

                          810
                   ....*....|....
gi 1039770408  730 RLLEEQAKLQQQMD 743
Cdd:pfam01576 1048 RANAARRKLQRELD 1061
C1_KSR cd20812
protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) ...
 940-991 2.08e-08

protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) family; KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. KSR proteins contain a SAM-like domain, a zinc finger cysteine-rich domain (C1), and a pseudokinase domain. This model describes the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410362  Cd Length: 48  Bit Score: 51.56  E-value: 2.08e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770408  940 IPHRFNVGLNMRATkCAVCLDTVHFGRqasKCLECQVMCHPKCSTCLPATCG 991
Cdd:cd20812      1 IKHRFSKKLFMRQT-CDYCHKQMFFGL---KCKDCKYKCHKKCAKKAPPSCG 48
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 10-728 2.22e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 59.31  E-value: 2.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKalqlLHDIREQSRK 89
Cdd:TIGR02169  363 KEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAA----IAGIEAKINE 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   90 LQEIKEqEYQAQVEEMRLMMNQLEEDLVSARRRS-------DLYESELRESR--LAAEEFKRKANECQHKLMKVVSHPPR 160
Cdd:TIGR02169  439 LEEEKE-DKALEIKKQEWKLEQLAADLSKYEQELydlkeeyDRVEKELSKLQreLAEAEAQARASEERVRGGRAVEEVLK 517

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  161 GDSGGtalddLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLeKAVKAStEATEL-LQNIRQakerA 239
Cdd:TIGR02169  518 ASIQG-----VHGTVAQLGSVGERYATAIEVAAGNRLNNVVVEDDAVAKEAIELL-KRRKAG-RATFLpLNKMRD----E 586

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  240 ERELEKLHnrEDSSEGIKKKLVeaeELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADK---------- 309
Cdd:TIGR02169  587 RRDLSILS--EDGVIGFAVDLV---EFDPKYEPAFKYVFGDTLVVEDIEAARRLMGKYRMVTLEGELFEKsgamtggsra 661

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  310 -ESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAnklaansslftqrnMKAQEEMISELRQQKFY 388
Cdd:TIGR02169  662 pRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQE--------------LSDASRKIGEIEKEIEQ 727

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  389 LETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVslehEEQKLELKRQLTELQLSL-----QERESQLTAL 463
Cdd:TIGR02169  728 LEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEEL----EEDLHKLEEALNDLEARLshsriPEIQAELSKL 803

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  464 QAARAALESQLRQAKTELEETTAEAEEEiqaltahRDEIQRKFDALRnsctvitDLEEQLNQLTEDNAELNNQNFYLSKQ 543
Cdd:TIGR02169  804 EEEVSRIEARLREIEQKLNRLTLEKEYL-------EKEIQELQEQRI-------DLKEQIKSIEKEIENLNGKKEELEEE 869

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  544 LDEASGAndeIVQLRSEVDHLRREITEREMQLTSQKQAQlsapdlqtmEALKTTCTMLEEQVLDL----EALNDELLEKE 619
Cdd:TIGR02169  870 LEELEAA---LRDLESRLGDLKKERDELEAQLRELERKI---------EELEAQIEKKRKRLSELkaklEALEEELSEIE 937

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  620 RQWEAWRSVLGDEKSqfecrvrelqrmLDTEKQSRARADQRITESRQVVELAVKEHkaeilalqqalkeqklkaESLSDK 699
Cdd:TIGR02169  938 DPKGEDEEIPEEELS------------LEDVQAELQRVEEEIRALEPVNMLAIQEY------------------EEVLKR 987

                          730       740
                   ....*....|....*....|....*....
gi 1039770408  700 LNDLEKKHAMLEMNARSLQQKLETERELK 728
Cdd:TIGR02169  988 LDELKEKRAKLEEERKAILERIEEYEKKK 1016
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 10-776 2.85e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.90  E-value: 2.85e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   10 EQEMTRLHRRVSEVEA---VLSQKEVELKASETQRSLLEQdlatyITECSSLKRSLEQARMEVSQEDDkALQLLHDIREQ 86
Cdd:TIGR00606  318 ERELVDCQRELEKLNKerrLLNQEKTELLVEQGRLQLQAD-----RHQEHIRARDSLIQSLATRLELD-GFERGPFSERQ 391

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   87 SRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPPRGDSGG- 165
Cdd:TIGR00606  392 IKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSd 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  166 ----------TALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQEL---QEKLEKAVKASTEATELLQNI 232
Cdd:TIGR00606  472 rileldqelrKAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLnhhTTTRTQMEMLTKDKMDKDEQI 551

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  233 RQAKERAERELEKL----HNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLEvhlkQKEQHYEEKIKVLDNQIKK---- 304
Cdd:TIGR00606  552 RKIKSRHSDELTSLlgyfPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLE----QNKNHINNELESKEEQLSSyedk 627

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  305 --DLADKESLENMMQRHEEEAHEKGKilseQKAMINAmdsKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISEL 382
Cdd:TIGR00606  628 lfDVCGSQDEESDLERLKEEIEKSSK----QRAMLAG---ATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDL 700

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  383 RQQKFYLETQAGKLEAQNRKLEEQLEKI--------SHQDHSDKsRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQ 454
Cdd:TIGR00606  701 QSKLRLAPDKLKSTESELKKKEKRRDEMlglapgrqSIIDLKEK-EIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMP 779

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  455 ERES------QLTALQAARAALESQLRQ-AKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC----TVITDLEEQL 523
Cdd:TIGR00606  780 EEESakvcltDVTIMERFQMELKDVERKiAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIelnrKLIQDQQEQI 859

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  524 NQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIteremqltSQKQAQLSaPDLQTMEalkttctmlee 603
Cdd:TIGR00606  860 QHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREI--------KDAKEQDS-PLETFLE----------- 919

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  604 qvlDLEALNDELLEKERQweawrsvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRqvvELAVKEHKAEILALQ 683
Cdd:TIGR00606  920 ---KDQQEKEELISSKET----------SNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGK---DDYLKQKETELNTVN 983

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  684 QALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL----------ETERELKQRLLE-----------EQAKLQQQM 742
Cdd:TIGR00606  984 AQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLtlrkrenelkEVEEELKQHLKEmgqmqvlqmkqEHQKLEENI 1063

                          810       820       830
                   ....*....|....*....|....*....|....
gi 1039770408  743 DLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQ 776
Cdd:TIGR00606 1064 DLIKRNHVLALGRQKGYEKEIKHFKKELREPQFR 1097
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 204-410 3.22e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 3.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  204 QQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNR-EDSSEGIKKKLVEAEELEEKHREAQVSAQHLEV 282
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRiAALARRIRALEQELAALEAELAELEKEIAELRA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  283 HLKQKEQHYEEKIKVLDNQIKKDL-------ADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS 355
Cdd:COG4942     98 ELEAQKEELAELLRALYRLGRQPPlalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039770408  356 EANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI 410
Cdd:COG4942    178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 396-743 4.90e-08

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 57.38  E-value: 4.90e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  396 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEeqklELKRQLTELQLSLQERESQLTALQAARAALESQLR 475
Cdd:pfam19220   25 LKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYG----KLRRELAGLTRRLSAAEGELEELVARLAKLEAALR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  476 QAKTELEETTAeaeeeiqaltahrdeiqrkfdALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandeiv 555
Cdd:pfam19220  101 EAEAAKEELRI---------------------ELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAE------- 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  556 QLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLE-EQVLD-----LEALNDELLEK-------ERQW 622
Cdd:pfam19220  153 KALQRAEGELATARERLALLEQENRRLQALSEEQAAELAELTRRLAElETQLDatrarLRALEGQLAAEqaereraEAQL 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  623 EAWRSVLGDEKSQFECRVRELQ-RMLDTEK---QSRARADQRiTESRQVVELAVKEHKAEILALQQALKEQKLKAESLSD 698
Cdd:pfam19220  233 EEAVEAHRAERASLRMKLEALTaRAAATEQllaEARNQLRDR-DEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQ 311

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1039770408  699 KLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 743
Cdd:pfam19220  312 QFQEMQRARAELEERAEMLTKALAAKDAALERAEERIASLSDRIA 356
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1023-1142 5.11e-08

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 52.56  E-value: 5.11e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1023 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1102
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039770408 1103 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1142
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 662-873 6.50e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.70  E-value: 6.50e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  662 TESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ 741
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  742 MDLQKNHIFRLTQGLQ------------------EALDRADLLKTERSDLEYQLENIQvlysHEKVKMEGTISQQTKLID 803
Cdd:COG4942     99 LEAQKEELAELLRALYrlgrqpplalllspedflDAVRRLQYLKYLAPARREQAEELR----ADLAELAALRAELEAERA 174

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  804 FLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAA 873
Cdd:COG4942    175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 9-559 7.12e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 57.49  E-value: 7.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    9 MEQEMTRLHRRVSEVEAvlSQKEVELKASETQRSLleQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 88
Cdd:pfam01576  494 LEDERNSLQEQLEEEEE--AKRNVERQLSTLQAQL--SDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYD 569

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   89 KLQEIKEQeYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLA----AEEFKRKANECQHKLMKVVSHPPRGDSG 164
Cdd:pfam01576  570 KLEKTKNR-LQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAIsaryAEERDRAEAEAREKETRALSLARALEEA 648

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  165 GTALDDLHKMQGH-----AGLTSAKDQGKPEVGEYSKlEKINAEQQLKIQELQ-EKLEKAVKASTEATELLQ-NIRQAKE 237
Cdd:pfam01576  649 LEAKEELERTNKQlraemEDLVSSKDDVGKNVHELER-SKRALEQQVEEMKTQlEELEDELQATEDAKLRLEvNMQALKA 727

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  238 RAERELeklHNREDSSEGIKKKLV------EAEELEEKHREAQVSA--QHLEVHLKQKEQHYEEKIKVLDNQIKKdLADK 309
Cdd:pfam01576  728 QFERDL---QARDEQGEEKRRQLVkqvrelEAELEDERKQRAQAVAakKKLELDLKELEAQIDAANKGREEAVKQ-LKKL 803

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  310 ESLENMMQRHEEEAHekgkiLSEQKAMINAMDS--KIRSLEQRIVELSEanKLAANSSLFTQRNM---KAQEEMI----- 379
Cdd:pfam01576  804 QAQMKDLQRELEEAR-----ASRDEILAQSKESekKLKNLEAELLQLQE--DLAASERARRQAQQerdELADEIAsgasg 876

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  380 -SELRQQKFYLETQAGKLEAQNRklEEQLEKISHQDHSDKSRLL--ELETRL---REVSLEHEEQKLELKRQLTELQLSL 453
Cdd:pfam01576  877 kSALQDEKRRLEARIAQLEEELE--EEQSNTELLNDRLRKSTLQveQLTTELaaeRSTSQKSESARQQLERQNKELKAKL 954

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  454 QERESQ--------LTALQAARAALESQLRQ--------AKTELEETTAEAEEEIQALTAHRDEIQRKfDALRNSCTVIT 517
Cdd:pfam01576  955 QEMEGTvkskfkssIAALEAKIAQLEEQLEQesrerqaaNKLVRRTEKKLKEVLLQVEDERRHADQYK-DQAEKGNSRMK 1033

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*.
gi 1039770408  518 DLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND----EIVQLRS 559
Cdd:pfam01576 1034 QLKRQLEEAEEEASRANAARRKLQRELDDATESNEsmnrEVSTLKS 1079
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
186-582 8.03e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 57.08  E-value: 8.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  186 QGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLhnredssegikkKLVEAEE 265
Cdd:COG4717    126 QLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQL------------SLATEEE 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  266 LEEKHREAQvsaqhlevHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAH-EKGKILSEQKAMINAMDSKI 344
Cdd:COG4717    194 LQDLAEELE--------ELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERlKEARLLLLIAAALLALLGLG 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  345 RSLEQRIVELSEANKL-AANSSLFTQRNMKAQEEMISELRQqkfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLE 423
Cdd:COG4717    266 GSLLSLILTIAGVLFLvLGLLALLFLLLAREKASLGKEAEE----LQALPALEELEEEELEELLAALGLPPDLSPEELLE 341

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  424 LETRLREV-----SLEHEEQKLELKRQLTELQLSLQ--------------ERESQLTALQAARAALESQLRQAKTELEEt 484
Cdd:COG4717    342 LLDRIEELqellrEAEELEEELQLEELEQEIAALLAeagvedeeelraalEQAEEYQELKEELEELEEQLEELLGELEE- 420

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  485 taeaeeeiQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQldeasganDEIVQLRSEVDHL 564
Cdd:COG4717    421 --------LLEALDEEELEEELEELEEE---LEELEEELEELREELAELEAELEQLEED--------GELAELLQELEEL 481

                          410
                   ....*....|....*...
gi 1039770408  565 RREITEREMQLTSQKQAQ 582
Cdd:COG4717    482 KAELRELAEEWAALKLAL 499
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 427-762 9.22e-08

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 57.27  E-value: 9.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  427 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAkteleettAEAEEEIQALTAHRDEIQRKF 506
Cdd:COG3096    282 ELSERALELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYQAA--------SDHLNLVQTALRQQEKIERYQ 353

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  507 DALrnsctviTDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREIterEMQLTSQKQAQlsap 586
Cdd:COG3096    354 EDL-------EELTERLEEQEEVVEEAAEQ---LAEAEARLEAAEEEVDSLKSQLADYQQAL---DVQQTRAIQYQ---- 416

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  587 dlQTMEALKTTCTMLEEQVLDLEALNDELLE-KERQWEAWRSVLGDE---------KSQFECRVRELQRMLDTEKQSRA- 655
Cdd:COG3096    417 --QAVQALEKARALCGLPDLTPENAEDYLAAfRAKEQQATEEVLELEqklsvadaaRRQFEKAYELVCKIAGEVERSQAw 494

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  656 -RADQRITESRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHA-------MLEMNARSLQQKLETER 725
Cdd:COG3096    495 qTARELLRRYRSQQALAQRLQqlRAQLAELEQRLRQQQ-NAERL---LEEFCQRIGqqldaaeELEELLAELEAQLEELE 570

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 1039770408  726 ELKQRLLEEQAKLQQQMDLQKNHIFRLTQ------GLQEALDR 762
Cdd:COG3096    571 EQAAEAVEQRSELRQQLEQLRARIKELAArapawlAAQDALER 613
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 234-477 1.15e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.93  E-value: 1.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  234 QAKERAERELEKLHNRedssegIKKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQhyeeKIKVLDNQIKKdladkesLE 313
Cdd:COG4942     20 DAAAEAEAELEQLQQE------IAELEKELAALKKEEKALLKQLAALERRIAALAR----RIRALEQELAA-------LE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  314 NMMQRHEEEAHEKGKILSEQKAMINAMdskIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQA 393
Cdd:COG4942     83 AELAELEKEIAELRAELEAQKEELAEL---LRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADL 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  394 GKLEAQNRKLEEQlekishqdhsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQ 473
Cdd:COG4942    160 AELAALRAELEAE-----------RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228


                   ....
gi 1039770408  474 LRQA 477
Cdd:COG4942    229 IARL 232
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
542-788 1.21e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.85  E-value: 1.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  542 KQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSapdlQTMEALKTTCTMLEEQVLDLEALNDELLEKERQ 621
Cdd:COG4913    252 ELLEPIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLE----AELEELRAELARLEAELERLEARLDALREELDE 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  622 WE-AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRItesrQVVELAVKEHKAEILALQQALKEQKLKAESLSDKl 700
Cdd:COG4913    328 LEaQIRGNGGDRLEQLEREIERLERELEERERRRARLEALL----AALGLPLPASAEEFAALRAEAAALLEALEEELEA- 402

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  701 ndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDR-ADLLKTERSDLEYQLEN 779
Cdd:COG4913    403 ----------------LEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDAlAEALGLDEAELPFVGEL 466


                   ....*....
gi 1039770408  780 IQVLYSHEK 788
Cdd:COG4913    467 IEVRPEEER 475
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
56-478 1.32e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.31  E-value: 1.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   56 SSLKRSLEQARMEVSQEDDKALQL-LHDIREQSRKLQEIKEQEyqAQVEEMRLMMNQLEEDLVSARRRSDLYESELR--E 132
Cdd:COG4717     45 AMLLERLEKEADELFKPQGRKPELnLKELKELEEELKEAEEKE--EEYAELQEELEELEEELEELEAELEELREELEklE 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  133 SRLAAEEFKRKANECQHKLmkvvshpprgDSGGTALDDL-HKMQGHAGLTSAKDQGKPEVGEYSklEKINAEQQLKIQEL 211
Cdd:COG4717    123 KLLQLLPLYQELEALEAEL----------AELPERLEELeERLEELRELEEELEELEAELAELQ--EELEELLEQLSLAT 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  212 QEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHR-------------------- 271
Cdd:COG4717    191 EEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLllliaaallallglggslls 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  272 -----------EAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKEsLENMMQRHEEEAHEKGKILSEQKAMINAM 340
Cdd:COG4717    271 liltiagvlflVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEE-LEELLAALGLPPDLSPEELLELLDRIEEL 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  341 DSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKfyletqagkleaQNRKLEEQLEKISHQdhsdksr 420
Cdd:COG4717    350 QELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAE------------EYQELKEELEELEEQ------- 410

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770408  421 lLELETRLREVSLEHEEQKlELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 478
Cdd:COG4717    411 -LEELLGELEELLEALDEE-ELEEELEELEEELEELEEELEELREELAELEAELEQLE 466
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 1023-1142 1.83e-07

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 50.62  E-value: 1.83e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  1023 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1102
Cdd:smart00233    1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1039770408  1103 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1142
Cdd:smart00233   69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 361-586 1.88e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.16  E-value: 1.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  361 AANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKL 440
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  441 ELKRQLTELQ-----LSLQERESQLTALQAARAALESQ-----LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALR 510
Cdd:COG4942     98 ELEAQKEELAellraLYRLGRQPPLALLLSPEDFLDAVrrlqyLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770408  511 nscTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAP 586
Cdd:COG4942    178 ---ALLAELEEERAALEALKAERQKLLARLEKELAELA---AELAELQQEAEELEALIARLEAEAAAAAERTPAAG 247
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
210-722 2.04e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.08  E-value: 2.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  210 ELQEKLEKAvkasTEATELLQNIRQAKERAERELEKLHNREDSSEGIK-----KKLVEAEELEEKHREAQVSAQHLEVHL 284
Cdd:COG4913    239 RAHEALEDA----REQIELLEPIRELAERYAAARERLAELEYLRAALRlwfaqRRLELLEAELEELRAELARLEAELERL 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  285 KQKEQHYEEKIKVLDNQIKK-DLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAAN 363
Cdd:COG4913    315 EARLDALREELDELEAQIRGnGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLE 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  364 SSlftqrnmkaqEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREvSLEHEEQKL--- 440
Cdd:COG4913    395 AL----------EEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALAE-ALGLDEAELpfv 463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  441 -ELkrqlteLQLSLQERESQLTA-----------------LQAARAALES-QLRQAKTELEETTAEAEEEIQALTAH--- 498
Cdd:COG4913    464 gEL------IEVRPEEERWRGAIervlggfaltllvppehYAAALRWVNRlHLRGRLVYERVRTGLPDPERPRLDPDsla 537

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  499 --------------RDEIQRKFD--------ALRNSCTVIT-----------------DLEEQLNQLTEDNAELNNQnfy 539
Cdd:COG4913    538 gkldfkphpfrawlEAELGRRFDyvcvdspeELRRHPRAITragqvkgngtrhekddrRRIRSRYVLGFDNRAKLAA--- 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  540 LSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKE 619
Cdd:COG4913    615 LEAELAEL---EEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDDLAALE 691

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  620 RQWEAWRSvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDK 699
Cdd:COG4913    692 EQLEELEA----ELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDAVEREL 767

                          570       580
                   ....*....|....*....|...
gi 1039770408  700 LNDLEKKHAMLEMNARSLQQKLE 722
Cdd:COG4913    768 RENLEERIDALRARLNRAEEELE 790
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
502-743 2.43e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 55.79  E-value: 2.43e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  502 IQRKFDALRNSctvITDLEEQLNQLTE--DNAELNNQNFYLSKQL----DEASGANDEIVQLRSEVDHLRREITEREMQL 575
Cdd:COG3206    166 LELRREEARKA---LEFLEEQLPELRKelEEAEAALEEFRQKNGLvdlsEEAKLLLQQLSELESQLAEARAELAEAEARL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  576 tSQKQAQLSAPDLQTMEALKTTctmleeqvlDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRA 655
Cdd:COG3206    243 -AALRAQLGSGPDALPELLQSP---------VIQQLRAQLAELEAELAELSARYTPNHPD----VIALRAQIAALRAQLQ 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  656 RADQRITESRQVvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLekkhamlemnaRSLQQKLETERELKQRLLE-- 733
Cdd:COG3206    309 QEAQRILASLEA---ELEALQAREASLQAQLAQLEARLAELPELEAEL-----------RRLEREVEVARELYESLLQrl 374

                          250
                   ....*....|
gi 1039770408  734 EQAKLQQQMD 743
Cdd:COG3206    375 EEARLAEALT 384
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 75-815 2.47e-07

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 55.82  E-value: 2.47e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   75 KALQLLHDIRE-QSRKLQEIKE-----QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELresrlaaEEFKRKANECQ 148
Cdd:TIGR00606  186 KALETLRQVRQtQGQKVQEHQMelkylKQYKEKACEIRDQITSKEAQLESSREIVKSYENEL-------DPLKNRLKEIE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  149 HKLMKVVShpprgdsggtaLDDlhkmqghagltsakdqgkpevgEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATEL 228
Cdd:TIGR00606  259 HNLSKIMK-----------LDN----------------------EIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLND 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  229 LQNIRQAKERaerelEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLEVhlkQKEQHYEEKIK----VLDNQIKK 304
Cdd:TIGR00606  306 LYHNHQRTVR-----EKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQL---QADRHQEHIRArdslIQSLATRL 377

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  305 DLaDKESLENMMQRHEEEAHEKGKILSEQKA-----MINAMDSKIRSLEQRIVELSEANKLAANSslfTQRNMKAQEEMI 379
Cdd:TIGR00606  378 EL-DGFERGPFSERQIKNFHTLVIERQEDEAktaaqLCADLQSKERLKQEQADEIRDEKKGLGRT---IELKKEILEKKQ 453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  380 SELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELEtRLREVSLEHEeqKLELKRQLTELQLSLQERE-- 457
Cdd:TIGR00606  454 EELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNSLTETL-KKEVKSLQNE--KADLDRKLRKLDQEMEQLNhh 530

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  458 ----SQLTALQAARAALESQLRQAKTELEETTAEAEEEI-------QALTAHRDEIQRKFDALRNSCTVITDLEEQLNQL 526
Cdd:TIGR00606  531 tttrTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFpnkkqleDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHI 610

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  527 TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM-------------QLTSQKQA--QLSAPDLQTM 591
Cdd:TIGR00606  611 NNELESKEEQLSSYEDKLFDVCGSQDEESDLERLKEEIEKSSKQRAMlagatavysqfitQLTDENQSccPVCQRVFQTE 690

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  592 EALKTTCTMLEEQVL----DLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLD-TEKQSRARADQRITESRQ 666
Cdd:TIGR00606  691 AELQEFISDLQSKLRlapdKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNkLQKVNRDIQRLKNDIEEQ 770

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  667 VVELAV---KEHKAEIL--------ALQQALKEQKLKAESLSDKLN--DLEKKHAMLEMNARSLQQKLET---ERELKQR 730
Cdd:TIGR00606  771 ETLLGTimpEEESAKVCltdvtimeRFQMELKDVERKIAQQAAKLQgsDLDRTVQQVNQEKQEKQHELDTvvsKIELNRK 850

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  731 LLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTErsdLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 810
Cdd:TIGR00606  851 LIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQ---LVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEE 927


                   ....*
gi 1039770408  811 QPAKK 815
Cdd:TIGR00606  928 LISSK 932
mukB PRK04863
chromosome partition protein MukB;
233-644 3.15e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 55.73  E-value: 3.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  233 RQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQ---HLEVHLKQKEQHYEEKIKVL--DNQIKKDLA 307
Cdd:PRK04863   276 RHANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEaesDLEQDYQAASDHLNLVQTALrqQEKIERYQA 355

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  308 DKESLENMMqrheEEAHEKGKILSEQKAMINAmdsKIRSLEQRIVELseANKLAAnsslfTQRNMKAQEEMISELRQQKF 387
Cdd:PRK04863   356 DLEELEERL----EEQNEVVEEADEQQEENEA---RAEAAEEEVDEL--KSQLAD-----YQQALDVQQTRAIQYQQAVQ 421

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  388 YLE-----TQAGKLEAQNrkLEEQLEKISHQDHSDKSRLLELETRLR--EVSLEHEEQKLELKRQLT-ELqlslqEREsq 459
Cdd:PRK04863   422 ALErakqlCGLPDLTADN--AEDWLEEFQAKEQEATEELLSLEQKLSvaQAAHSQFEQAYQLVRKIAgEV-----SRS-- 492

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  460 lTALQAARAALEsQLRQAKTELEETtaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY 539
Cdd:PRK04863   493 -EAWDVARELLR-RLREQRHLAEQL--------QQLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEE 562

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  540 LSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDlqtmeALKTTCTMLEEQVLD---LEALNDELL 616
Cdd:PRK04863   563 LEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARAPAWLAAQD-----ALARLREQSGEEFEDsqdVTEYMQQLL 637

                          410       420
                   ....*....|....*....|....*...
gi 1039770408  617 EKERQWEAWRSVLGDEKSQFECRVRELQ 644
Cdd:PRK04863   638 ERERELTVERDELAARKQALDEEIERLS 665
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 193-478 3.27e-07

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 54.96  E-value: 3.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  193 EYSKLEKINAEqqLKIQELQEKLEKAVKASTEATELLQNIRQAKERAeRELEKLHNREDSSEGIKKKLVEAEEleekhre 272
Cdd:COG5185    254 KLEKLVEQNTD--LRLEKLGENAESSKRLNENANNLIKQFENTKEKI-AEYTKSIDIKKATESLEEQLAAAEA------- 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  273 aqvsaqhlEVHLKQKEQHYEEKIKVLDNQIKKdlaDKESLENMMQRHEEEAHEKGKI--LSEQKAMINAMDSKIRSLEQR 350
Cdd:COG5185    324 --------EQELEESKRETETGIQNLTAEIEQ---GQESLTENLEAIKEEIENIVGEveLSKSSEELDSFKDTIESTKES 392

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  351 IVELSEANKLAANSSLFT-QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQdhSDKSRLLELETRLR 429
Cdd:COG5185    393 LDEIPQNQRGYAQEILATlEDTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISELNKVMRE--ADEESQSRLEEAYD 470

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1039770408  430 EVSLEHEEQKLELKRQLTELQLSLQEresQLTALQAARAALESQLRQAK 478
Cdd:COG5185    471 EINRSVRSKKEDLNEELTQIESRVST---LKATLEKLRAKLERQLEGVR 516
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 58-742 3.99e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 55.23  E-value: 3.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   58 LKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDlYESELRESRLAA 137
Cdd:pfam12128  214 PKSRLNRQQVEHWIRDIQAIAGIMKIRPEFTKLQQEFNT-----LESAELRLSHLHFGYKSDETLIA-SRQEERQETSAE 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  138 EEFKRKANECQhklMKVVSHPPRGDSGgTALDDLHKMQGHagLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEK 217
Cdd:pfam12128  288 LNQLLRTLDDQ---WKEKRDELNGELS-AADAAVAKDRSE--LEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEE 361

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  218 AVKASTEA----TELLQNIRQA-KERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHY- 291
Cdd:pfam12128  362 RLKALTGKhqdvTAKYNRRRSKiKEQNNRDIAGIKDKLAKIREARDRQLAVAEDDLQALESELREQLEAGKLEFNEEEYr 441

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  292 -EEKIKVLDNQIKKDLADKESLENMMQRHEEeahekgkilseqkamINAMDSKIrsleqrivELSEANKLAANSSLFTQR 370
Cdd:pfam12128  442 lKSRLGELKLRLNQATATPELLLQLENFDER---------------IERAREEQ--------EAANAEVERLQSELRQAR 498

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  371 nmKAQEEMISELRQQKFYLETQAGKLEAqnrkLEEQLEKISH-------------QDHSDK--SRLLELETRLREVSLEH 435
Cdd:pfam12128  499 --KRRDQASEALRQASRRLEERQSALDE----LELQLFPQAGtllhflrkeapdwEQSIGKviSPELLHRTDLDPEVWDG 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  436 EEQ--------KLELKR----QLTELQLSLQERESQL-TALQAAR---AALESQLRQAKTELEETTAEAEEEIQALTAHR 499
Cdd:pfam12128  573 SVGgelnlygvKLDLKRidvpEWAASEEELRERLDKAeEALQSARekqAAAEEQLVQANGELEKASREETFARTALKNAR 652

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  500 DEIQRKFDALRNsctvitdLEEQLNQLTEDNAELNNQNFylsKQLDEASGANDEIVQLRSEvdHLRREITEREMQLTSQK 579
Cdd:pfam12128  653 LDLRRLFDEKQS-------EKDKKNKALAERKDSANERL---NSLEAQLKQLDKKHQAWLE--EQKEQKREARTEKQAYW 720

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  580 QAQLSAPDLQtMEALKTTCTMLEEQvldLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRaradQ 659
Cdd:pfam12128  721 QVVEGALDAQ-LALLKAAIAARRSG---AKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRR----Q 792

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  660 RITESRQVVELAVKEHKaeilalqQALKEQKLKAESlsdKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQ 735
Cdd:pfam12128  793 EVLRYFDWYQETWLQRR-------PRLATQLSNIER---AISELQQQLARLIADTKLRRAKLEMERkaseKQQVRLSENL 862


                   ....*..
gi 1039770408  736 AKLQQQM 742
Cdd:pfam12128  863 RGLRCEM 869
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 214-783 7.73e-07

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 54.28  E-value: 7.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  214 KLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEE 293
Cdd:TIGR00606  180 SATRYIKALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEH 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  294 ---KIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQ-KAMINAMDSKIRSLEQRIVELseanklaansslftQ 369
Cdd:TIGR00606  260 nlsKIMKLDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQlNDLYHNHQRTVREKERELVDC--------------Q 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  370 RNMKAQEEMISELRQQKFYLETQAGKLeaqnrkleeQLEKISHQDHSDK--SRLLELETRLREVSLEHEEQKLELKRQLT 447
Cdd:TIGR00606  326 RELEKLNKERRLLNQEKTELLVEQGRL---------QLQADRHQEHIRArdSLIQSLATRLELDGFERGPFSERQIKNFH 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  448 ELQLSLQERESQLTALQAARaaLESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLT 527
Cdd:TIGR00606  397 TLVIERQEDEAKTAAQLCAD--LQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRIL 474

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  528 EDNAELNNQNFYLSKqLDEasgaNDEIVQLRSEVDHLRREITE--REMQLTSQKQAQLS--APDLQTMEALKTTCTMLEE 603
Cdd:TIGR00606  475 ELDQELRKAERELSK-AEK----NSLTETLKKEVKSLQNEKADldRKLRKLDQEMEQLNhhTTTRTQMEMLTKDKMDKDE 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  604 QVLDLEALNDELL-------EKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRItESRQVVELAVKEHK 676
Cdd:TIGR00606  550 QIRKIKSRHSDELtsllgyfPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNEL-ESKEEQLSSYEDKL 628

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  677 AEILALQqalkEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERE-------LKQRLLEEQAKLQQqmdlqknHI 749
Cdd:TIGR00606  629 FDVCGSQ----DEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDenqsccpVCQRVFQTEAELQE-------FI 697

                          570       580       590
                   ....*....|....*....|....*....|....
gi 1039770408  750 FRLTQGLQEALDRADLLKTERSDLEYQLENIQVL 783
Cdd:TIGR00606  698 SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGL 731
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 307-510 7.82e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 7.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  307 ADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQk 386
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE- 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  387 fyLETQAGKLEAQNRKL-----EEQLEKISHQDHSDKS------------RLLELETRLREVSLEHEEQKLELKRQLTEL 449
Cdd:COG4942     99 --LEAQKEELAELLRALyrlgrQPPLALLLSPEDFLDAvrrlqylkylapARREQAEELRADLAELAALRAELEAERAEL 176

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770408  450 QLSLQERESQLTALQAARAALESQLRQAKteleETTAEAEEEIQALTAHRDEIQRKFDALR 510
Cdd:COG4942    177 EALLAELEEERAALEALKAERQKLLARLE----KELAELAAELAELQQEAEELEALIARLE 233
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 2-742 9.54e-07

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 54.03  E-value: 9.54e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKA-------SETQRSLLEQDLATYITECSSLKRSLEQARM------- 67
Cdd:pfam01576  213 LEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAalarleeETAQKNNALKKIRELEAQISELQEDLESERAarnkaek 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   68 ----------------EVSQEDDKALQLLHDIREQS----RKLQEIKEQEYQAQVEEMRLMMNQ----LEEDLVSARR-R 122
Cdd:pfam01576  293 qrrdlgeelealktelEDTLDTTAAQQELRSKREQEvtelKKALEEETRSHEAQLQEMRQKHTQaleeLTEQLEQAKRnK 372

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  123 SDLYES----ELRESRLAAE-----------EFKRKANECQ-HKLMKVVSHPPRGDSggTALDDLHKMQGH-----AGLT 181
Cdd:pfam01576  373 ANLEKAkqalESENAELQAElrtlqqakqdsEHKRKKLEGQlQELQARLSESERQRA--ELAEKLSKLQSElesvsSLLN 450

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  182 SAKDQGKPEVGEYSKLE-KINAEQQLKIQELQEKLEKA--VKASTEATELLQNIRQAKERAERELEK-LHNREDSSEGIK 257
Cdd:pfam01576  451 EAEGKNIKLSKDVSSLEsQLQDTQELLQEETRQKLNLStrLRQLEDERNSLQEQLEEEEEAKRNVERqLSTLQAQLSDMK 530

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  258 KKLVE----AEELEEKHREAQVSAQHLEVHLKQKEQHYE--EKIKV-LDNQIKKDLADKESLENMMQRHEEEAHEKGKIL 330
Cdd:pfam01576  531 KKLEEdagtLEALEEGKKRLQRELEALTQQLEEKAAAYDklEKTKNrLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQML 610

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  331 SEQKAMINAM-------DSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQ----EEMIS----------ELRQQKFYL 389
Cdd:pfam01576  611 AEEKAISARYaeerdraEAEAREKETRALSLARALEEALEAKEELERTNKQLraemEDLVSskddvgknvhELERSKRAL 690

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  390 ETQAGKLEAQNRKLEEQLekishQDHSDKSRLLELETRLREVSLEH---------EEQKLELKRQLTELQLSLQERESQL 460
Cdd:pfam01576  691 EQQVEEMKTQLEELEDEL-----QATEDAKLRLEVNMQALKAQFERdlqardeqgEEKRRQLVKQVRELEAELEDERKQR 765

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  461 TALQAARAALESQLRQAKTELEETTAEAEEEIQAL---TAHRDEIQRKFDALRNSCTVI-----------TDLEEQLNQL 526
Cdd:pfam01576  766 AQAVAAKKKLELDLKELEAQIDAANKGREEAVKQLkklQAQMKDLQRELEEARASRDEIlaqskesekklKNLEAELLQL 845

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  527 TEDNA------------------ELNNQNFYLSKQLDEASGANDEIVQLRSEvdhLRREITEREMQLTSQKQAQLSAPDL 588
Cdd:pfam01576  846 QEDLAaserarrqaqqerdeladEIASGASGKSALQDEKRRLEARIAQLEEE---LEEEQSNTELLNDRLRKSTLQVEQL 922

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  589 QT-MEALKTTCTMLEEQVLDLEALNDELLEKERQWE-AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ--RITES 664
Cdd:pfam01576  923 TTeLAAERSTSQKSESARQQLERQNKELKAKLQEMEgTVKSKFKSSIAALEAKIAQLEEQLEQESRERQAANKlvRRTEK 1002

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770408  665 R-QVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM 742
Cdd:pfam01576 1003 KlKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDDATESNESMNREVSTLKSKL 1081
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 318-755 1.44e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 53.42  E-value: 1.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  318 RHEEEAHEK-GKILSEQKAMINAMDsKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQ 392
Cdd:COG3096    275 RHANERRELsERALELRRELFGARR-QLAEEQYRLVEMArELEELSARESDLEQDYQAASDHlnlVQTALRQQE-KIERY 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  393 AGKLEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVSLEHEEqkleLKRQLTELQLSLQERESQLTALQAARAALEs 472
Cdd:COG3096    353 QEDLEELTERLEEQEEVVEEAA----EQLAEAEARLEAAEEEVDS----LKSQLADYQQALDVQQTRAIQYQQAVQALE- 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  473 qlrQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNqLTEDNAELNNQNFYLSKQLD---EASG 549
Cdd:COG3096    424 ---KARALCGLPDLTPENAEDYLAAFRAKEQQATEEVL-------ELEQKLS-VADAARRQFEKAYELVCKIAgevERSQ 492

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  550 ANDEIVQLRSE----------VDHLRREITEREMQLTSQKQAQLSAPDLQTMEALK-TTCTMLEEQVLDLEALNDELLEK 618
Cdd:COG3096    493 AWQTARELLRRyrsqqalaqrLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQlDAAEELEELLAELEAQLEELEEQ 572

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  619 ERQWEAWRSVLGDEKSQFECRVRELqrmldtekqsRARADQRITESRQVVELAvkEHKAEILALQQALKEQklkaeslsd 698
Cdd:COG3096    573 AAEAVEQRSELRQQLEQLRARIKEL----------AARAPAWLAAQDALERLR--EQSGEALADSQEVTAA--------- 631

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  699 klndlekkhamlemnarsLQQKLETERELKQ---RLLEEQAKLQQQmdlqknhIFRLTQG 755
Cdd:COG3096    632 ------------------MQQLLEREREATVerdELAARKQALESQ-------IERLSQP 666
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
11-570 1.58e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.00  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   11 QEMTRLHRRVSEVEAVLSQkeVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQS-RK 89
Cdd:COG4913    262 ERYAAARERLAELEYLRAA--LRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGgDR 339

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   90 LQEIKEQeyqaqveemrlmMNQLEEDLVSARRRSDLYESELRESRLA----AEEFKRKANECQHKLmkvvshpprgdsgg 165
Cdd:COG4913    340 LEQLERE------------IERLERELEERERRRARLEALLAALGLPlpasAEEFAALRAEAAALL-------------- 393

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  166 TALDDLHKmQGHAGLTSAKDQGKPEVGEYSKLEK-INAEQQLK------IQELQEKLEKAVKASTE----ATELLQnIRQ 234
Cdd:COG4913    394 EALEEELE-ALEEALAEAEAALRDLRRELRELEAeIASLERRKsniparLLALRDALAEALGLDEAelpfVGELIE-VRP 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  235 AKERAERELEK-LHNR------EDSSEGIKKKLVEAEELEEKHREAQVSAQHLEVHLKQ-KEQHYEEKIKVLDNQ----I 302
Cdd:COG4913    472 EEERWRGAIERvLGGFaltllvPPEHYAAALRWVNRLHLRGRLVYERVRTGLPDPERPRlDPDSLAGKLDFKPHPfrawL 551

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  303 KKDLADK------ESLENM-----------MQRHEEEAHEKG-KILSEQKAMI---NAmdSKIRSLEQRIVELseankla 361
Cdd:COG4913    552 EAELGRRfdyvcvDSPEELrrhpraitragQVKGNGTRHEKDdRRRIRSRYVLgfdNR--AKLAALEAELAEL------- 622

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  362 ansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDhsdksRLLELETRLREVSLEHEEQKlE 441
Cdd:COG4913    623 -------EEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAER-----EIAELEAELERLDASSDDLA-A 689

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  442 LKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeEEIQALTAHRDEIQRKFDAlrnscTVITDLEE 521
Cdd:COG4913    690 LEEQLEELEAELEELEEELDELKGEIGRLEKELEQAE-----------EELDELQDRLEAAEDLARL-----ELRALLEE 753

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 1039770408  522 QLNQLTEDNAElnnqnfylsKQLDEAsgANDEIVQLRSEVDHLRREITE 570
Cdd:COG4913    754 RFAAALGDAVE---------RELREN--LEERIDALRARLNRAEEELER 791
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 333-605 1.70e-06

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 53.13  E-value: 1.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  333 QKAMINAMDSKIRSLEQRIVELSEANKLaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQ--NRKLEEQLEKI 410
Cdd:PRK10929    43 QAEIVEALQSALNWLEERKGSLERAKQY--------QQVIDNFPKLSAELRQQLNNERDEPRSVPPNmsTDALEQEILQV 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  411 SHQdHSDKSRLLELET-RLREVS---LEHEEQKLELKRQLTELQLSLQERESQLTAL-QAARAAL--ESQLRQAKTELEE 483
Cdd:PRK10929   115 SSQ-LLEKSRQAQQEQdRAREISdslSQLPQQQTEARRQLNEIERRLQTLGTPNTPLaQAQLTALqaESAALKALVDELE 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  484 TTAEAEEEIQALTAHRDEI-QRKFDALRNSctvITDLEEQLNQLTEDNAElnnQNFYLSKQLDEASG--ANDEIVQLRse 560
Cdd:PRK10929   194 LAQLSANNRQELARLRSELaKKRSQQLDAY---LQALRNQLNSQRQREAE---RALESTELLAEQSGdlPKSIVAQFK-- 265

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039770408  561 vdhLRREITE------REMQLTSQKQAQLSAPDLQTMEALKTtctmLEEQV 605
Cdd:PRK10929   266 ---INRELSQalnqqaQRMDLIASQQRQAASQTLQVRQALNT----LREQS 309
C1_1 pfam00130
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ...
 937-992 1.92e-06

Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.


Pssm-ID: 395079  Cd Length: 53  Bit Score: 46.28  E-value: 1.92e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770408  937 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 992
Cdd:pfam00130    1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 653-930 2.02e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 52.14  E-value: 2.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  653 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 730
Cdd:COG3883     10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  731 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 807
Cdd:COG3883     86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  808 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 887
Cdd:COG3883    141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1039770408  888 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 930
Cdd:COG3883    221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 2-325 2.04e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 52.76  E-value: 2.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKR---SLEQARMEVSQEDDKALQ 78
Cdd:TIGR02169  686 LKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEdlsSLEQEIENVKSELKELEA 765

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   79 LLHDIREQSRKLQE----IKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELrESRLAAEEFKRKanECQHKLMKV 154
Cdd:TIGR02169  766 RIEELEEDLHKLEEalndLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKL-NRLTLEKEYLEK--EIQELQEQR 842

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  155 VSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPE--VGEYSKLEKINAEQQLKIQELQEKLEKAvKASTEATELLQNI 232
Cdd:TIGR02169  843 IDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRdlESRLGDLKKERDELEAQLRELERKIEEL-EAQIEKKRKRLSE 921

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  233 RQAK-ERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLE-VHLKQKEQHYEEKIKVLDNQIKKD--LAD 308
Cdd:TIGR02169  922 LKAKlEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRALEpVNMLAIQEYEEVLKRLDELKEKRAklEEE 1001

                          330
                   ....*....|....*..
gi 1039770408  309 KESLENMMQRHEEEAHE 325
Cdd:TIGR02169 1002 RKAILERIEEYEKKKRE 1018
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 547-875 2.35e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 52.53  E-value: 2.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  547 ASGANDEIVQL-----RSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALkttctMLEEQVLDLEALNDELLEKERQ 621
Cdd:pfam12128  204 AILEDDGVVPPksrlnRQQVEHWIRDIQAIAGIMKIRPEFTKLQQEFNTLESA-----ELRLSHLHFGYKSDETLIASRQ 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  622 wEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLN 701
Cdd:pfam12128  279 -EERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELE 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  702 DLEKKHAMLEMNARSLQQKLETEREL-KQRLLEEQAKLQQQMDLQKNHIFRltqglQEALDRADLLKTErSDLEYQLENI 780
Cdd:pfam12128  358 NLEERLKALTGKHQDVTAKYNRRRSKiKEQNNRDIAGIKDKLAKIREARDR-----QLAVAEDDLQALE-SELREQLEAG 431

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  781 QVLYSHEKVKMEGTISQQTKLIDFLQAkmdqpakkkkglfsrrkeDPALPTQVPLQYNELKLALEKEKARCAELEeALQK 860
Cdd:pfam12128  432 KLEFNEEEYRLKSRLGELKLRLNQATA------------------TPELLLQLENFDERIERAREEQEAANAEVE-RLQS 492

                          330
                   ....*....|....*
gi 1039770408  861 TRIELRSAREEAAHR 875
Cdd:pfam12128  493 ELRQARKRRDQASEA 507
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 374-610 2.87e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.69  E-value: 2.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  374 AQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVslehEEQKLELKRQLTELQLSL 453
Cdd:COG4942     17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRAL----EQELAALEAELAELEKEI 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  454 QERESQLTALqaaRAALESQLRQAKTELEETTAeaeeeiqALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAEL 533
Cdd:COG4942     93 AELRAELEAQ---KEELAELLRALYRLGRQPPL-------ALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAEL 162

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770408  534 NNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQlsapdLQTMEALKTTCTMLEEQVLDLEA 610
Cdd:COG4942    163 AALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAEL-----AAELAELQQEAEELEALIARLEA 234
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 2-744 4.05e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 51.71  E-value: 4.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    2 LLGEEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSL---KRSLEQARMEVSQEddkalq 78
Cdd:pfam01576   94 LQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLskeRKLLEERISEFTSN------ 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   79 lLHDIREQSRKLQEIKEQeYQAQVEEMRLMMNQLE---EDLVSARRRSDLYESELRES----RLAAEEFK----RKANEC 147
Cdd:pfam01576  168 -LAEEEEKAKSLSKLKNK-HEAMISDLEERLKKEEkgrQELEKAKRKLEGESTDLQEQiaelQAQIAELRaqlaKKEEEL 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  148 QHKLMKVvshPPRGDSGGTALDDLHKMQGHagLTSAKDQGKPEVGEYSKLEK----------------------INAEQQ 205
Cdd:pfam01576  246 QAALARL---EEETAQKNNALKKIRELEAQ--ISELQEDLESERAARNKAEKqrrdlgeelealkteledtldtTAAQQE 320

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  206 LKIQELQE--KLEKAVKASTEATEL-LQNIRQAKERAEREL-EKLHNREDSSEGIKK-KLVEAEELEEKHREAQVsaqhl 280
Cdd:pfam01576  321 LRSKREQEvtELKKALEEETRSHEAqLQEMRQKHTQALEELtEQLEQAKRNKANLEKaKQALESENAELQAELRT----- 395

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  281 evhLKQKEQHYEEKIKVLDNQikkdLADKESLENMMQRHEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEankl 360
Cdd:pfam01576  396 ---LQQAKQDSEHKRKKLEGQ----LQELQARLSESERQRAELAEK---LSKLQSELESVSSLLNEAEGKNIKLSK---- 461

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  361 aANSSLFTQrnMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK-------ISHQDHSDKSRLLELETRLREVSL 433
Cdd:pfam01576  462 -DVSSLESQ--LQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEeeeakrnVERQLSTLQAQLSDMKKKLEEDAG 538

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  434 ---EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETtaeaeeeiQALTAHRDEIQRKFD-AL 509
Cdd:pfam01576  539 tleALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQ--------RQLVSNLEKKQKKFDqML 610

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  510 RNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEI----VQLRSEVDHLrreiteremqLTSQKQAQLSA 585
Cdd:pfam01576  611 AEEKAISARYAEERDRAEAEAREKETRALSLARALEEALEAKEELertnKQLRAEMEDL----------VSSKDDVGKNV 680

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  586 PDL--------QTMEALKTTCTMLEEQvldLEALNDELLEKERQWEAW----------RSVLGDEK-SQFECRVRELQRM 646
Cdd:pfam01576  681 HELerskraleQQVEEMKTQLEELEDE---LQATEDAKLRLEVNMQALkaqferdlqaRDEQGEEKrRQLVKQVRELEAE 757

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  647 LDTEKQSRARAdqriTESRQVVELAVKEHKAEILALQQ----ALKEQKLKAESLSDKLNDLEKKHAMLEmnaRSLQQKLE 722
Cdd:pfam01576  758 LEDERKQRAQA----VAAKKKLELDLKELEAQIDAANKgreeAVKQLKKLQAQMKDLQRELEEARASRD---EILAQSKE 830

                          810       820
                   ....*....|....*....|..
gi 1039770408  723 TERELKQRlleEQAKLQQQMDL 744
Cdd:pfam01576  831 SEKKLKNL---EAELLQLQEDL 849
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 5-459 4.18e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 51.66  E-value: 4.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQ-RSLLEQDLATYITeCSSLKRSLEQARMEVSQEDD--KAL---- 77
Cdd:pfam15921  364 ERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQnKRLWDRDTGNSIT-IDHLRRELDDRNMEVQRLEAllKAMksec 442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   78 -----QLLHDIREQSRKLQEIkeQEYQAQVEEMRLMMNQLEEDLVSA--------------------------------- 119
Cdd:pfam15921  443 qgqmeRQMAAIQGKNESLEKV--SSLTAQLESTKEMLRKVVEELTAKkmtlessertvsdltaslqekeraieatnaeit 520

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  120 --RRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHKMQGHAGLTSA-----KDQGKPEVG 192
Cdd:pfam15921  521 klRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGamqveKAQLEKEIN 600

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  193 ----EYSKLEKINAEQQLKIQELQEK-----LEKaVKASTEATELLQNIRQAKERAERELEKLHN-REDSSEGIKKKLVE 262
Cdd:pfam15921  601 drrlELQEFKILKDKKDAKIRELEARvsdleLEK-VKLVNAGSERLRAVKDIKQERDQLLNEVKTsRNELNSLSEDYEVL 679

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  263 AEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLdnqikkdladkESLENMMQRHEEEAHEKGKILSEQKAMINAMDS 342
Cdd:pfam15921  680 KRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTL-----------KSMEGSDGHAMKVAMGMQKQITAKRGQIDALQS 748

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  343 KIRSLEQrivELSEANKlaANSSLFTQRNMKAQEemISELRQQKFYLETQAGKLEAQNRKLEEqlekishqdhsdksRLL 422
Cdd:pfam15921  749 KIQFLEE---AMTNANK--EKHFLKEEKNKLSQE--LSTVATEKNKMAGELEVLRSQERRLKE--------------KVA 807

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 1039770408  423 ELETRLREVSLEHEEQKLELKRQLTE-----LQLSLQERESQ 459
Cdd:pfam15921  808 NMEVALDKASLQFAECQDIIQRQEQEsvrlkLQHTLDVKELQ 849
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 493-722 4.40e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.92  E-value: 4.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  493 QALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgaNDEIVQLRSEVDHLRREITERE 572
Cdd:COG4942     16 AAQADAAAEAEAELEQLQQE---IAELEKELAALKKEEKALLKQLAALERRIAAL---ARRIRALEQELAALEAELAELE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  573 MQLtSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQ 652
Cdd:COG4942     90 KEI-AELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQ----AEELRADLAELAA 164

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  653 SRaradQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 722
Cdd:COG4942    165 LR----AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 201-867 4.98e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 51.36  E-value: 4.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  201 NAEQQLKIQELQEKLekavKASTEATELLQNIRQAKERAEREleKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHL 280
Cdd:pfam10174   69 NQHLQLTIQALQDEL----RAQRDLNQLLQQDFTTSPVDGED--KFSTPELTEENFRRLQSEHERQAKELFLLRKTLEEM 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  281 EVHLKQKEQHYEEKikvlDNQIKKDLADKESlENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKl 360
Cdd:pfam10174  143 ELRIETQKQTLGAR----DESIKKLLEMLQS-KGLPKKSGEEDWERTRRIAEAEMQLGHLEVLLDQKEKENIHLREELH- 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  361 aansslftQRNMKAQE-EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQ-DHSDKSRllELETRLREVSLEHEEQ 438
Cdd:pfam10174  217 --------RRNQLQPDpAKTKALQTVIEMKDTKISSLERNIRDLEDEVQMLKTNgLLHTEDR--EEEIKQMEVYKSHSKF 286

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  439 kleLKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTaeaeeeiQALTAHRDE---IQRKFDALRNSC-- 513
Cdd:pfam10174  287 ---MKNKIDQLKQELSKKESELLALQTKLETLTNQNSDCKQHIEVLK-------ESLTAKEQRaaiLQTEVDALRLRLee 356

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  514 --TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSapdLQTM 591
Cdd:pfam10174  357 keSFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVK---ERKINVLQKKIENLQEQLRDKDKQLAGLKERVKS---LQTD 430

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  592 EALKTTCtmleeqvldLEALNDELLEKERQWEAWRsvlgdEKSQFECRVR--ELQRMLDTEKQSRARAD--QRITESRQV 667
Cdd:pfam10174  431 SSNTDTA---------LTTLEEALSEKERIIERLK-----EQREREDRERleELESLKKENKDLKEKVSalQPELTEKES 496

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  668 VELAVKEHkAEILALQQALKEQKLKA---------ESLSDKLNDLEKKHAMlEMNARSLQQKLETERELKQ---RLLEEQ 735
Cdd:pfam10174  497 SLIDLKEH-ASSLASSGLKKDSKLKSleiaveqkkEECSKLENQLKKAHNA-EEAVRTNPEINDRIRLLEQevaRYKEES 574

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  736 AKLQQQMDlqknhifRLTQGLQEAldradllKTERSDLEYQLENIQVLYSHEkvkmegtISQQTKLIDflQAKMDQPAKK 815
Cdd:pfam10174  575 GKAQAEVE-------RLLGILREV-------ENEKNDKDKKIAELESLTLRQ-------MKEQNKKVA--NIKHGQQEMK 631

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770408  816 KKGLfsrRKEDPALPTQVPLQYNELKLALEkekarcaELEEALQKTRIELRS 867
Cdd:pfam10174  632 KKGA---QLLEEARRREDNLADNSQQLQLE-------ELMGALEKTRQELDA 673
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
15-571 5.51e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.45  E-value: 5.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   15 RLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATyitecssLKRSLEQARMEVSQEDDKAL-QLLHDIREQSRKLQEI 93
Cdd:COG4913    285 FAQRRLELLEAELEELRAELARLEAELERLEARLDA-------LREELDELEAQIRGNGGDRLeQLEREIERLERELEER 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   94 KE--QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKvvshpprgdsggtALDDL 171
Cdd:COG4913    358 ERrrARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRR-------------ELREL 424

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  172 hkmqgHAGLTSAKDQGKPevgeysklekINAEQqlkiQELQEKLEKAVKASTE----ATELLQnIRQAKERAERELEK-L 246
Cdd:COG4913    425 -----EAEIASLERRKSN----------IPARL----LALRDALAEALGLDEAelpfVGELIE-VRPEEERWRGAIERvL 484

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  247 HNR------EDSSEGIKKKLVEAEELEEKHREAQVSAQHLEVHLKQ-KEQHYEEKIKVLDNQ----IKKDLADK------ 309
Cdd:COG4913    485 GGFaltllvPPEHYAAALRWVNRLHLRGRLVYERVRTGLPDPERPRlDPDSLAGKLDFKPHPfrawLEAELGRRfdyvcv 564

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  310 ESLENM-----------MQRHEEEAHEKG---KILSEQ------KAMINAMDSKIRSLEQRIVELSEANKLAANSslftQ 369
Cdd:COG4913    565 DSPEELrrhpraitragQVKGNGTRHEKDdrrRIRSRYvlgfdnRAKLAALEAELAELEEELAEAEERLEALEAE----L 640

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  370 RNMKAQEEMISELRQQKFYlETQAGKLEAQNRKLEEQLEKIShqdhSDKSRLLELETRLREVSLEH---EEQKLELKRQL 446
Cdd:COG4913    641 DALQERREALQRLAEYSWD-EIDVASAEREIAELEAELERLD----ASSDDLAALEEQLEELEAELeelEEELDELKGEI 715

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  447 TELQLSLQERESQLTALQAA------------RAALESQLRQAKTELEETTAEAEEEiQALTAHRDEIQRKFDALRN--- 511
Cdd:COG4913    716 GRLEKELEQAEEELDELQDRleaaedlarlelRALLEERFAAALGDAVERELRENLE-ERIDALRARLNRAEEELERamr 794

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039770408  512 ---------SCTVITDLE------EQLNQLTEDNAELNNQNFylSKQLDEASgaNDEIVQLRSEVDHLRREITER 571
Cdd:COG4913    795 afnrewpaeTADLDADLEslpeylALLDRLEEDGLPEYEERF--KELLNENS--IEFVADLLSKLRRAIREIKER 865
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 547-818 5.97e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.53  E-value: 5.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  547 ASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDlqtmealkttctmleeqvlDLEALNDELLEKERQweawr 626
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLK-------------------QLAALERRIAALARR----- 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  627 svlgdeksqfecrVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKK 706
Cdd:COG4942     71 -------------IRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRR 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  707 HAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKnhifRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSH 786
Cdd:COG4942    138 LQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE----ALLAELEEERAALEALKAERQKLLARLEKELAELAA 213

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1039770408  787 EKVKMEGTISQQTKLIDFLQAKMDQPAKKKKG 818
Cdd:COG4942    214 ELAELQQEAEELEALIARLEAEAAAAAERTPA 245
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 516-747 6.57e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.53  E-value: 6.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  516 ITDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREI--TEREMQLTSQKQAQLSAPdlqtMEA 593
Cdd:COG4942     22 AAEAEAELEQLQQEIAELEKE---LAALKKEEKALLKQLAALERRIAALARRIraLEQELAALEAELAELEKE----IAE 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  594 LKTTctmLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLdtekQSRARADQRITESRQVVELAVK 673
Cdd:COG4942     95 LRAE---LEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLA----PARREQAEELRADLAELAALRA 167

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039770408  674 EHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKN 747
Cdd:COG4942    168 ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 198-868 7.98e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 51.11  E-value: 7.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  198 EKInAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERE--------------LEKLHNREDSSEGIKKKLVEA 263
Cdd:COG3096    347 EKI-ERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEvdslksqladyqqaLDVQQTRAIQYQQAVQALEKA 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  264 EELEEKHREAQVSAQHLEVHLKQKEQHYEEKikVLDNQIKKDLAD--KESLENMMQRHE--------EEAHEKGKIL--- 330
Cdd:COG3096    426 RALCGLPDLTPENAEDYLAAFRAKEQQATEE--VLELEQKLSVADaaRRQFEKAYELVCkiageverSQAWQTARELlrr 503

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  331 -SEQKAMI---NAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQ---EEMISELRQQKFYLETQAGKLEAQNRKL 403
Cdd:COG3096    504 yRSQQALAqrlQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAAeelEELLAELEAQLEELEEQAAEAVEQRSEL 583

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  404 EEQLEKISHQDHSDKSR---LLELETRLREVSlEHEEQKLELKRQLTELQLSLQERESQLTA----LQAARAALESQLRQ 476
Cdd:COG3096    584 RQQLEQLRARIKELAARapaWLAAQDALERLR-EQSGEALADSQEVTAAMQQLLEREREATVerdeLAARKQALESQIER 662

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  477 AKTELEETTAEAEEEIQALTAH-----RDEIQRK----FDAL----RNScTVITDLE---EQLNQLT---------EDNA 531
Cdd:COG3096    663 LSQPGGAEDPRLLALAERLGGVllseiYDDVTLEdapyFSALygpaRHA-IVVPDLSavkEQLAGLEdcpedlyliEGDP 741

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  532 ELNNQNFYLSKQLDEASGANDEIVQLR----SEVDHLRR-------EITEREMQLTSQKQAQLSApDLQTMEALKTTCTM 600
Cdd:COG3096    742 DSFDDSVFDAEELEDAVVVKLSDRQWRysrfPEVPLFGRaarekrlEELRAERDELAEQYAKASF-DVQKLQRLHQAFSQ 820

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  601 LEEQVLDLEALNDEllekerqwEAWRSVLGDEKSQFEcrvRELQRMLDTEKQSRARADQ---RITESRQVVELAVKEHKA 677
Cdd:COG3096    821 FVGGHLAVAFAPDP--------EAELAALRQRRSELE---RELAQHRAQEQQLRQQLDQlkeQLQLLNKLLPQANLLADE 889

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  678 EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEeqakLQQQMDLQKNHIFRLTQGLQ 757
Cdd:COG3096    890 TLADRLEELREELDAAQEAQAFIQQHGKALAQLEPLVAVLQSDPEQFEQLQADYLQ----AKEQQRRLKQQIFALSEVVQ 965

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  758 --EAL---DRADLLkTERSD----LEYQLENIQVLYSHEKVKMEGtisQQTKLIDFLQAKMDQPAK---KKKGLFSRRKE 825
Cdd:COG3096    966 rrPHFsyeDAVGLL-GENSDlnekLRARLEQAEEARREAREQLRQ---AQAQYSQYNQVLASLKSSrdaKQQTLQELEQE 1041

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039770408  826 DPALPTQVP--------LQYNELKLALEKEKARCAELEEALQKTRIELRSA 868
Cdd:COG3096   1042 LEELGVQADaeaeerarIRRDELHEELSQNRSRRSQLEKQLTRCEAEMDSL 1092
PRK01156 PRK01156
chromosome segregation protein; Provisional
 17-444 9.20e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 50.67  E-value: 9.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   17 HRRVSEVEAVLSQKEVELKASETQRSLLEqDLATYITECSSLKRSLEQARMEVsQEDDKALQLLHDIREQSRKLQEIKEQ 96
Cdd:PRK01156   328 IKKLSVLQKDYNDYIKKKSRYDDLNNQIL-ELEGYEMDYNSYLKSIESLKKKI-EEYSKNIERMSAFISEILKIQEIDPD 405

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   97 EYQAQVEEMRLMMNQLEEDLVSARRRSDlyesELRESRlaaEEFKRKANECQHKLMKVVSHPPRGDSGGTALDDlHKMQG 176
Cdd:PRK01156   406 AIKKELNEINVKLQDISSKVSSLNQRIR----ALRENL---DELSRNMEMLNGQSVCPVCGTTLGEEKSNHIIN-HYNEK 477

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  177 HAGLTSAKDQGKPEVgeysklEKINaEQQLKIQELQEKLEKAvkastEATELLQNIRQAKErAERELEKLHNREDSsegI 256
Cdd:PRK01156   478 KSRLEEKIREIEIEV------KDID-EKIVDLKKRKEYLESE-----EINKSINEYNKIES-ARADLEDIKIKINE---L 541

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  257 KKKLVEAEELEEKHReaqvsAQHLEVhLKQKEQHYEEKIKVLD-----------NQIKKDLADKESlenmmqRHEEEAHE 325
Cdd:PRK01156   542 KDKHDKYEEIKNRYK-----SLKLED-LDSKRTSWLNALAVISlidietnrsrsNEIKKQLNDLES------RLQEIEIG 609

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  326 KGKILSEQKAMINAMDSKIRSLEQRIVELsEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE 405
Cdd:PRK01156   610 FPDDKSYIDKSIREIENEANNLNNKYNEI-QENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRK 688

                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 1039770408  406 QLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR 444
Cdd:PRK01156   689 ALDDAKANRARLESTIEILRTRINELSDRINDINETLES 727
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
494-872 1.14e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 50.42  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  494 ALTAHRDEIQRKFDAlrNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM 573
Cdd:PRK02224   188 SLDQLKAQIEEKEEK--DLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  574 QLTSqkqaqlsapDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQS 653
Cdd:PRK02224   266 TIAE---------TEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVA 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  654 -----------RARADQRITESRQVVELAvKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 722
Cdd:PRK02224   337 aqahneeaeslREDADDLEERAEELREEA-AELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLE 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  723 TERELKQRLLEEQAKLQQQMDLQKNHIfRLTQGLQEA---------------LDRADLLKTERSDLEYQLENIQVlyshE 787
Cdd:PRK02224   416 ELREERDELREREAELEATLRTARERV-EEAEALLEAgkcpecgqpvegsphVETIEEDRERVEELEAELEDLEE----E 490

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  788 KVKMEGTISQQTKLIDfLQAKMDQPAKKKKGLFSRRKEDPAlptqvplQYNELKLALEKEKARCAELEEALQKTRIELRS 867
Cdd:PRK02224   491 VEEVEERLERAEDLVE-AEDRIERLEERREDLEELIAERRE-------TIEEKRERAEELRERAAELEAEAEEKREAAAE 562


                   ....*
gi 1039770408  868 AREEA 872
Cdd:PRK02224   563 AEEEA 567
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 437-708 1.21e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  437 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQrkfdalrnsctvi 516
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE--------------RRIAALARRIR------------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  517 tDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEivQLRSevdHLRREITEREMQLTSQKQAQLSAPDLQTMEALKT 596
Cdd:COG4942     73 -ALEQELAALEAELAELEKEIAELRAELEAQKEELAE--LLRA---LYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAP 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  597 TctmLEEQVLDLEALNDELLEKERQWEAWRsvlgdeksqfecrvRELQRMLDTEKQSRARADQRITESRQVvelaVKEHK 676
Cdd:COG4942    147 A---RREQAEELRADLAELAALRAELEAER--------------AELEALLAELEEERAALEALKAERQKL----LARLE 205

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1039770408  677 AEILALQQALKEQKLKAESLSDKLNDLEKKHA 708
Cdd:COG4942    206 KELAELAAELAELQQEAEELEALIARLEAEAA 237
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1499-1590 1.26e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.07  E-value: 1.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1499 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1562
Cdd:PTZ00449   527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606

                           90       100       110
                   ....*....|....*....|....*....|
gi 1039770408 1563 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1590
Cdd:PTZ00449   607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 207-455 1.40e-05

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 48.10  E-value: 1.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  207 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNR----EDSSEGIKKKLVEA-EELEEKHREAQVSAQHLE 281
Cdd:pfam00261    2 KMQQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRiqllEEELERTEERLAEAlEKLEEAEKAADESERGRK 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  282 VhLKQKEQHYEEKIKVLDNQIKKdladkeslenmMQRHEEEAHEKGKILSEQKAMINA----MDSKIRSLEQRIVELSEA 357
Cdd:pfam00261   82 V-LENRALKDEEKMEILEAQLKE-----------AKEIAEEADRKYEEVARKLVVVEGdlerAEERAELAESKIVELEEE 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  358 NKLAANSSlftqRNMKAQEEMISElRQQKFyletqagklEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEE 437
Cdd:pfam00261  150 LKVVGNNL----KSLEASEEKASE-REDKY---------EEQIRFLTEKLKEAETRAEFAERSVQKLEKEVDRLEDELEA 215

                          250
                   ....*....|....*...
gi 1039770408  438 QKLELKRQLTELQLSLQE 455
Cdd:pfam00261  216 EKEKYKAISEELDQTLAE 233
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 333-536 1.45e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  333 QKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH 412
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  413 QDHSDKSRLLEL-------ETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 485
Cdd:COG4942     98 ELEAQKEELAELlralyrlGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039770408  486 AEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ 536
Cdd:COG4942    178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
COG5281 COG5281
Phage-related minor tail protein [Mobilome: prophages, transposons];
327-763 1.60e-05

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444092 [Multi-domain]  Cd Length: 603  Bit Score: 49.61  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  327 GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 406
Cdd:COG5281      3 ALAAAAALAAAAAAAAASAAAAAAAAALAAAAAAAAAAAGLAAAAAAAAAASLAAAAAAAALAAAAAAAAAAAAADALAA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  407 LEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQlslQERESQLTALQAARAALESQLRQAKTELEETTA 486
Cdd:COG5281     83 ALAEDAAAAAAAAEAALAALAAAALALAAAALAEAALAAAAAAA---AAAAAAAAAAAAAAAAAAEAAKAAAAAAAAAAL 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  487 EAEEEIQALTAHRDEIQRKFDALRNSctvitDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRR 566
Cdd:COG5281    160 AAAAAAAAAAAAAAAAAAALAAASAA-----AAAAAAKAAAEAAAEAAAAAEAAAAAAAAAAEAAAAEAQALAAAALAEQ 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  567 EITEREMQLTSQKQAQLSapDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecRVRELQRM 646
Cdd:COG5281    235 AALAAASAAAQALAALAA--AAAAAALALAAAAELALTAQAEAAAAAAAAAAAAAQAAEAAAAAAEAQA---LAAAAAAA 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  647 LDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERE 726
Cdd:COG5281    310 AAQLAAAAAAAAQALRAAAQALAALAQRALAAAALAAAAQEAALAAAAAALQAALE-----AAAAAAAAELAAAGDWAAG 384

                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 1039770408  727 LKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRA 763
Cdd:COG5281    385 AKAALAEYADSATNVAAQVAQAATSAFSGLTDALAGA 421
mukB PRK04863
chromosome partition protein MukB;
194-572 1.90e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 49.57  E-value: 1.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  194 YSKLEKINAEQQLKIqELQEKLEKAVKASTEateLLQNIRQAKER------AERELEKLHNREDSSEGIKKKLVEAEELE 267
Cdd:PRK04863   296 YTSRRQLAAEQYRLV-EMARELAELNEAESD---LEQDYQAASDHlnlvqtALRQQEKIERYQADLEELEERLEEQNEVV 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  268 EkhrEAQVSAQHLEVHLKQKEQHYEEkikvldnqIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSL 347
Cdd:PRK04863   372 E---EADEQQEENEARAEAAEEEVDE--------LKSQLADYQQALDVQQTRAIQYQQAVQALERAKQLCGLPDLTADNA 440

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  348 EQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQN-----RKLEEQLEKISHQDhsdkSRLL 422
Cdd:PRK04863   441 EDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEawdvaRELLRRLREQRHLA----EQLQ 516

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  423 ELETRLREVSLEHEEQKlELKRQLTELQLSLQ---ERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR 499
Cdd:PRK04863   517 QLRMRLSELEQRLRQQQ-RAERLLAEFCKRLGknlDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARI 595

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770408  500 DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITERE 572
Cdd:PRK04863   596 QRLAARAPAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALDEEIERLSQPG 668
C1_SpBZZ1-like cd20824
protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein ...
 941-991 1.98e-05

protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein BZZ1 and similar proteins; BZZ1 is a syndapin-like F-BAR protein that plays a role in endocytosis and trafficking to the vacuole. It functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress. BZZ1 contains an N-terminal F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs), a central coiled-coil, and two C-terminal SH3 domains. Schizosaccharomyces pombe BZZ1 also harbors a C1 domain, but Saccharomyces cerevisiae BZZ1 doesn't have any. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410374  Cd Length: 53  Bit Score: 43.46  E-value: 1.98e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770408  941 PHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 991
Cdd:cd20824      1 PHNFKPHSFSIPTKCDYCGEKIwGLSKKGLSCKDCGFNCHIKCELKVPPECP 52
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 196-448 2.09e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 49.66  E-value: 2.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  196 KLEKINA--EQQLKIQELQEKLEKAVKASTEATELLQNIRQAK---ERAERELEKLHNREDSSEgIKKKLVEAE------ 264
Cdd:TIGR01612 1471 KIKKDNAtnDHDFNINELKEHIDKSKGCKDEADKNAKAIEKNKelfEQYKKDVTELLNKYSALA-IKNKFAKTKkdseii 1549

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  265 --ELEEKHREAQVSAQHLEVHLKQKEQhyeEKIKVLDNQIKKDLADKESLEnmMQRHEEEAHEKGKILSEQKAMINAMDS 342
Cdd:TIGR01612 1550 ikEIKDAHKKFILEAEKSEQKIKEIKK---EKFRIEDDAAKNDKSNKAAID--IQLSLENFENKFLKISDIKKKINDCLK 1624

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  343 KIRSLEQRIVELS---EANKLAANSSlftqrNMKAQEEMISELRQQKFYLETQAGKLEaqnrKLEEQLEKISHQ-DHSDK 418
Cdd:TIGR01612 1625 ETESIEKKISSFSidsQDTELKENGD-----NLNSLQEFLESLKDQKKNIEDKKKELD----ELDSEIEKIEIDvDQHKK 1695

                          250       260       270
                   ....*....|....*....|....*....|
gi 1039770408  419 SRLLELETRLREVSLEHEEqKLELKRQLTE 448
Cdd:TIGR01612 1696 NYEIGIIEKIKEIAIANKE-EIESIKELIE 1724
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 10-269 2.28e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 89
Cdd:COG4942     26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   90 LQE-IKEQEYQAQVEEMRLMMNQleEDLVSARRRSDLYESELRESRLAAEEFKRKANEcqhklmkvvshpprgdsggtal 168
Cdd:COG4942    106 LAElLRALYRLGRQPPLALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAE---------------------- 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  169 ddlhkmqghagLTSAKDQgkpevgeyskLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHN 248
Cdd:COG4942    162 -----------LAALRAE----------LEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQ 220

                          250       260
                   ....*....|....*....|.
gi 1039770408  249 REDSSEGIKKKLVEAEELEEK 269
Cdd:COG4942    221 EAEELEALIARLEAEAAAAAE 241
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
246-871 2.31e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 49.27  E-value: 2.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  246 LHNREDSSEGIKKklvEAEELEEKHREAQVSAqhlevhLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHE 325
Cdd:PRK02224   182 LSDQRGSLDQLKA---QIEEKEEKDLHERLNG------LESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  326 kgkilseqkaminamdskIRSLEQRIVELSEanKLAAnsslfTQRNMKAQEEMISELRQQKFYLETQagkleaqnrkLEE 405
Cdd:PRK02224   253 ------------------LETLEAEIEDLRE--TIAE-----TEREREELAEEVRDLRERLEELEEE----------RDD 297

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  406 QLEKISHQDHSDKSRLLELEtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 485
Cdd:PRK02224   298 LLAEAGLDDADAEAVEARRE--------ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELE 369

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  486 aeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTE--DNAELnnqnfylskQLDEASGANDEivqLRSEVDH 563
Cdd:PRK02224   370 --------------SELEEAREAVEDRREEIEELEEEIEELRErfGDAPV---------DLGNAEDFLEE---LREERDE 423

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  564 LRreitEREMQLTSqkqaqlsapDLQTMEalkttcTMLEEqvldlealNDELLEKERQWEAWRSVLG----DEKSQFECR 639
Cdd:PRK02224   424 LR----EREAELEA---------TLRTAR------ERVEE--------AEALLEAGKCPECGQPVEGsphvETIEEDRER 476

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  640 VRELQRMLDTEKQSRARADQRITESRQVVELAVK----EHKAEilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNAR 715
Cdd:PRK02224   477 VEELEAELEDLEEEVEEVEERLERAEDLVEAEDRierlEERRE--DLEELIAERRETIEEKRERAEELRERAAELEAEAE 554

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  716 SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIfrltqglqEALDRADLLKTERSDLEYQLENIQvlyshEKVKMEGTI 795
Cdd:PRK02224   555 EKREAAAEAEEEAEEAREEVAELNSKLAELKERI--------ESLERIRTLLAAIADAEDEIERLR-----EKREALAEL 621

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770408  796 SQQTKliDFLQAKMDqpakKKKGLFSRRKEDpalptqvplqynelklALEKEKARCAELEEALQKTRIELRSAREE 871
Cdd:PRK02224   622 NDERR--ERLAEKRE----RKRELEAEFDEA----------------RIEEAREDKERAEEYLEQVEEKLDELREE 675
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 476-754 2.58e-05

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 48.27  E-value: 2.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  476 QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANdEIV 555
Cdd:pfam15905   66 QKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEE---LEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVN-ELL 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  556 QLRSEVDHLRREITEREMQLT------SQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEawrsvl 629
Cdd:pfam15905  142 KAKFSEDGTQKKMSSLSMELMklrnklEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKI------ 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  630 gDEKSQFECRVRELQRMldteKQSRARADQRITESRQVVELAvKEHKAEILALQQALKEqklKAESLSDKLNDLEKKHAM 709
Cdd:pfam15905  216 -EEKSETEKLLEYITEL----SCVSEQVEKYKLDIAQLEELL-KEKNDEIESLKQSLEE---KEQELSKQIKDLNEKCKL 286

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1039770408  710 LEmnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQ 754
Cdd:pfam15905  287 LE---SEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQQ 328
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 284-477 2.61e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.29  E-value: 2.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  284 LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMIN----AMDSKIRSLEQRIVELSEANK 359
Cdd:COG3883     28 LQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEerreELGERARALYRSGGSVSYLDV 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  360 LAANSSL--FTQRN------MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsdksrllELETRLREV 431
Cdd:COG3883    108 LLGSESFsdFLDRLsalskiADADADLLEELKADKAELEAKKAELEAKLAELEALKA--------------ELEAAKAEL 173

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1039770408  432 slehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 477
Cdd:COG3883    174 ----EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
mukB PRK04863
chromosome partition protein MukB;
238-757 2.85e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 49.19  E-value: 2.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  238 RAERE--LEKLHN-REDSSEGIKKKLVEAEELEEKHREA-QVSAQHLEVHLkqkEQHYEEKIKVLD---NQIKKDLADKE 310
Cdd:PRK04863   781 RAAREkrIEQLRAeREELAERYATLSFDVQKLQRLHQAFsRFIGSHLAVAF---EADPEAELRQLNrrrVELERALADHE 857

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  311 SLEnmmQRHEEEAhekgKILSEQKAMINAMDSKIR-----SLEQRIVELSEANKLAANSSLFTQRNMKA----------- 374
Cdd:PRK04863   858 SQE---QQQRSQL----EQAKEGLSALNRLLPRLNlladeTLADRVEEIREQLDEAEEAKRFVQQHGNAlaqlepivsvl 930

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  375 --QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLL----ELETRLREVSLEHEEQKLELKRQLTE 448
Cdd:PRK04863   931 qsDPEQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQRRAHFSYEDAAEMLaknsDLNEKLRQRLEQAEQERTRAREQLRQ 1010

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  449 LQLSLQERESQLTALQAARAALESQLRQAKTELEET-TAEAEEEIQALTAHRDEIQrkfDALRNSCTVITDLEEQLnQLT 527
Cdd:PRK04863  1011 AQAQLAQYNQVLASLKSSYDAKRQMLQELKQELQDLgVPADSGAEERARARRDELH---ARLSANRSRRNQLEKQL-TFC 1086

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  528 EdnAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITER--EMQLTSQKQAQLSAPDLQTMeALKttctmleeqv 605
Cdd:PRK04863  1087 E--AEMDNLTKKLRKLERDYHEMREQVVNAKAGWCAVLRLVKDNgvERRLHRRELAYLSADELRSM-SDK---------- 1153

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  606 lDLEAL------NDELLEKERQWEAWRSVlgDEKSQFECRVRELQRmldtekqSRARADqrITESRQVVElavkehkaei 679
Cdd:PRK04863  1154 -ALGALrlavadNEHLRDVLRLSEDPKRP--ERKVQFYIAVYQHLR-------ERIRQD--IIRTDDPVE---------- 1211

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770408  680 lALQQalkeqklkaesLSDKLNDLEKkhamlEMNARslQQKLETERElkqrllEEQAKLQQQMDLQKNHIFRLTQGLQ 757
Cdd:PRK04863  1212 -AIEQ-----------MEIELSRLTE-----ELTSR--EQKLAISSE------SVANIIRKTIQREQNRIRMLNQGLQ 1264
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 273-497 2.88e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.29  E-value: 2.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  273 AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV 352
Cdd:COG3883      3 ALALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  353 ELSEA-NKLAA----NSSLFTQRNMKAQEEMISELRQQKFYLETQAgklEAQNRKLEEQLEkishqdhsDKSRLLELETR 427
Cdd:COG3883     83 ERREElGERARalyrSGGSVSYLDVLLGSESFSDFLDRLSALSKIA---DADADLLEELKA--------DKAELEAKKAE 151

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  428 LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA 497
Cdd:COG3883    152 LEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 380-866 2.88e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 48.95  E-value: 2.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  380 SELRQQKFYLETQAGKLEAQNRKLEE---QLEKISH------QDHSDKSR-----------LLELETRLREVSLEHEEQK 439
Cdd:pfam05483   99 AELKQKENKLQENRKIIEAQRKAIQElqfENEKVSLkleeeiQENKDLIKennatrhlcnlLKETCARSAEKTKKYEYER 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  440 LELKRQLTELQLSLqerESQLTALQAARAalesQLRQAKTELEETTAEAEEEIQALtahRDEIQRKFDALRNSCTVItdl 519
Cdd:pfam05483  179 EETRQVYMDLNNNI---EKMILAFEELRV----QAENARLEMHFKLKEDHEKIQHL---EEEYKKEINDKEKQVSLL--- 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  520 eeqLNQLTEDNAELNNQNFYLSK------QLDEASGANDE-IVQLRSEVDHLRREITEREMQLTSQKQAQLS-APDLQTm 591
Cdd:pfam05483  246 ---LIQITEKENKMKDLTFLLEEsrdkanQLEEKTKLQDEnLKELIEKKDHLTKELEDIKMSLQRSMSTQKAlEEDLQI- 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  592 eALKTTCTMLEEQVLDLEALNDE-------LLEKERQWEAWRSVLGDEKSQFECRVRELqRMLDTEKQSRARADQRITES 664
Cdd:pfam05483  322 -ATKTICQLTEEKEAQMEELNKAkaahsfvVTEFEATTCSLEELLRTEQQRLEKNEDQL-KIITMELQKKSSELEEMTKF 399

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  665 RQVVELAVKEHKaEILALQQALKEQKLKAESLSDKLNDLEKKHAML----EMNARSLQQKLETERELKQRLLEEQAKLQQ 740
Cdd:pfam05483  400 KNNKEVELEELK-KILAEDEKLLDEKKQFEKIAEELKGKEQELIFLlqarEKEIHDLEIQLTAIKTSEEHYLKEVEDLKT 478

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  741 QMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQqtklIDFLQAKMDQpakkkkglf 820
Cdd:pfam05483  479 ELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQ----IENLEEKEMN--------- 545

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 1039770408  821 sRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELR 866
Cdd:pfam05483  546 -LRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMK 590
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 45-780 3.03e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 49.02  E-value: 3.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   45 EQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQeiKEQEYQAQVEEMRLMMnqleedlvsARRRSD 124
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQ--AETELCAEAEEMRARL---------AARKQE 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  125 LYE--SELrESRLAAEEfkrkanECQHKLMkvvshpprgdsggtalDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINA 202
Cdd:pfam01576   73 LEEilHEL-ESRLEEEE------ERSQQLQ----------------NEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTT 129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  203 EQQLK--------IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSegikkklveAEELEEKHREAQ 274
Cdd:pfam01576  130 EAKIKkleedillLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAM---------ISDLEERLKKEE 200

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  275 VSAQHLEVHLKQKEQHYEEkikvLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVEL 354
Cdd:pfam01576  201 KGRQELEKAKRKLEGESTD----LQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISEL 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  355 SEanklaansSLFTQRNMKAQEEmiselrQQKFYLETQagkLEAQNRKLEEQLEKISHQDHSDKSR---LLELETRLREV 431
Cdd:pfam01576  277 QE--------DLESERAARNKAE------KQRRDLGEE---LEALKTELEDTLDTTAAQQELRSKReqeVTELKKALEEE 339

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  432 SLEHEEQKLELKR----QLTELQLSLQERESQLTALQAARAALESQ----------LRQAKTELEETTAEAEEEIQALTA 497
Cdd:pfam01576  340 TRSHEAQLQEMRQkhtqALEELTEQLEQAKRNKANLEKAKQALESEnaelqaelrtLQQAKQDSEHKRKKLEGQLQELQA 419

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  498 HRDEIQRkfdalrnsctVITDLEEQLNQLTednAELNNqnfyLSKQLDEASGANdeiVQLRSEVDHLRREITEREMQLTS 577
Cdd:pfam01576  420 RLSESER----------QRAELAEKLSKLQ---SELES----VSSLLNEAEGKN---IKLSKDVSSLESQLQDTQELLQE 479

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  578 QKQAQLSapdlqtmeaLKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARA 657
Cdd:pfam01576  480 ETRQKLN---------LSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRL 550

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  658 DQRITESRQvvELAVKEHKAEILA-----LQQALKEQKLKAESLSDKLNDLEKKHamlemnaRSLQQKLETERELKQRLL 732
Cdd:pfam01576  551 QRELEALTQ--QLEEKAAAYDKLEktknrLQQELDDLLVDLDHQRQLVSNLEKKQ-------KKFDQMLAEEKAISARYA 621

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*...
gi 1039770408  733 EEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENI 780
Cdd:pfam01576  622 EERDRAEAEAREKETRALSLARALEEALEAKEELERTNKQLRAEMEDL 669
PRK11281 PRK11281
mechanosensitive channel MscK;
428-754 3.25e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 48.75  E-value: 3.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  428 LREVSLEHEEQKLeLKRQLTELQLSLQERESQ---LTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQR 504
Cdd:PRK11281    48 LNKQKLLEAEDKL-VQQDLEQTLALLDKIDRQkeeTEQLKQQLAQAPAKLRQAQAE-----------LEALKDDNDEETR 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  505 KfdalRNSCTVITDLEEQLNQLTEDNAELNNqnfylskqldEASGANDEIVQLRSEVDHLRREITE---REMQLTSQK-- 579
Cdd:PRK11281   116 E----TLSTLSLRQLESRLAQTLDQLQNAQN----------DLAEYNSQLVSLQTQPERAQAALYAnsqRLQQIRNLLkg 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  580 ----QAQLSAPDLQTMEAlkttctmleEQVLdLEALNDEllekERQWEAWRSVLGDeksqfecrVRELQRMLDTEKQsrA 655
Cdd:PRK11281   182 gkvgGKALRPSQRVLLQA---------EQAL-LNAQNDL----QRKSLEGNTQLQD--------LLQKQRDYLTARI--Q 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  656 RADQRITESRQVV---ELAVKEHKAEilALQQALKEQKLKAESLsdklndlekkhamlemnarsLQQKLETERELKQRLL 732
Cdd:PRK11281   238 RLEHQLQLLQEAInskRLTLSEKTVQ--EAQSQDEAARIQANPL--------------------VAQELEINLQLSQRLL 295

                          330       340
                   ....*....|....*....|....*
gi 1039770408  733 EEQAKLQQ--QMDLQ-KNHIFRLTQ 754
Cdd:PRK11281   296 KATEKLNTltQQNLRvKNWLDRLTQ 320
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 339-508 3.34e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 47.23  E-value: 3.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  339 AMDSKIRSLEQRIVELSEAnklaansslftqrnmkaqeemISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 418
Cdd:COG1579     14 ELDSELDRLEHRLKELPAE---------------------LAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  419 SRLLELETRLREVS-------LEHEEQKLELKRQLTE-LQLSLQER----ESQLTALQAARAALESQLRQAKTELEETTA 486
Cdd:COG1579     73 ARIKKYEEQLGNVRnnkeyeaLQKEIESLKRRISDLEdEILELMERieelEEELAELEAELAELEAELEEKKAELDEELA 152

                          170       180
                   ....*....|....*....|..
gi 1039770408  487 EAEEEIQALTAHRDEIQRKFDA 508
Cdd:COG1579    153 ELEAELEELEAEREELAAKIPP 174
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 501-810 3.37e-05

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 48.42  E-value: 3.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  501 EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY----LSKQLDEasgandEIVQLRSEVDHLRREITEREMQLT 576
Cdd:COG5185    233 EALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGenaeSSKRLNE------NANNLIKQFENTKEKIAEYTKSID 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  577 SQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQF--ECRVRELQRMLDTEKQSR 654
Cdd:COG5185    307 IKKATESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIvgEVELSKSSEELDSFKDTI 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  655 ARADQRITESRQVVELAVKEHKAeilALQQALKEQKLKAESLSDKLNDLEKKhamlemNARSLQQKLETERELKQRLLEE 734
Cdd:COG5185    387 ESTKESLDEIPQNQRGYAQEILA---TLEDTLKAADRQIEELQRQIEQATSS------NEEVSKLLNELISELNKVMREA 457

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770408  735 QAKLQQQMDLQKNHIFRltqGLQEALDRADLlktERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 810
Cdd:COG5185    458 DEESQSRLEEAYDEINR---SVRSKKEDLNE---ELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLK 527
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
11-384 3.71e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.61  E-value: 3.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   11 QEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATY--ITECSSLKRSLEQARMEVSQEDDKALQL---LHDIRE 85
Cdd:COG4717     81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLekLLQLLPLYQELEALEAELAELPERLEELeerLEELRE 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   86 QSRKLQEIKEQEYQAQVEEMRLM----------MNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMK-- 153
Cdd:COG4717    161 LEEELEELEAELAELQEELEELLeqlslateeeLQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAaa 240

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  154 -----------------VVSHPPRGDSGGTALDDLHKMQ---------GHAGLTSAKDQGKPEVGEYSKLEKINAEQQLK 207
Cdd:COG4717    241 leerlkearlllliaaaLLALLGLGGSLLSLILTIAGVLflvlgllalLFLLLAREKASLGKEAEELQALPALEELEEEE 320

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  208 IQELQEKLEKAVKAS-TEATELLQNIRQAK------ERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHL 280
Cdd:COG4717    321 LEELLAALGLPPDLSpEELLELLDRIEELQellreaEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQEL 400

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  281 EVHLKQKEQHYEEKIKVLDNQIkkDLADKESLENMMQRHEEEahekgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKL 360
Cdd:COG4717    401 KEELEELEEQLEELLGELEELL--EALDEEELEEELEELEEE-------LEELEEELEELREELAELEAELEQLEEDGEL 471

                          410       420
                   ....*....|....*....|....
gi 1039770408  361 AansslftqRNMKAQEEMISELRQ 384
Cdd:COG4717    472 A--------ELLQELEELKAELRE 487
C1_CeDKF1-like_rpt2 cd20798
second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine ...
 941-992 5.83e-05

second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine/threonine-protein kinase DKF-1 and similar proteins; DKF-1 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. It plays a role in the regulation of growth and neuromuscular control of movement. It is involved in immune response to Staphylococcus aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Members of this group contain two copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410348  Cd Length: 54  Bit Score: 42.10  E-value: 5.83e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039770408  941 PHRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGL 992
Cdd:cd20798      1 PHTLAEHNYKKPTVCKVC-DKLLVGlvRQGLKCRDCGVNVHKKCASLLPSNCRL 53
PH_ROCK cd01242
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ...
 1024-1069 5.83e-05

Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269948  Cd Length: 110  Bit Score: 43.88  E-value: 5.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1039770408 1024 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1069
Cdd:cd01242      2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 6-478 6.83e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 47.91  E-value: 6.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    6 EAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQD-----------LATYITECSSLKRSL------------ 62
Cdd:pfam12128  296 DDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDAdietaaadqeqLPSWQSELENLEERLkaltgkhqdvta 375

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   63 --EQARMEVSQEDDKALQLLHD----IREQSRKLQEIKEQEYQAQVEEMRLMMNQ------------------------- 111
Cdd:pfam12128  376 kyNRRRSKIKEQNNRDIAGIKDklakIREARDRQLAVAEDDLQALESELREQLEAgklefneeeyrlksrlgelklrlnq 455

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  112 ----------------------------------LEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMkvvsh 157
Cdd:pfam12128  456 atatpelllqlenfderierareeqeaanaeverLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLF----- 530

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  158 PPRG--------------DSGGTALDD--LHKMQGHAGLTSAKDQGKPEVGEYS-KLEKINAEQQLKI-QELQEKLEKAV 219
Cdd:pfam12128  531 PQAGtllhflrkeapdweQSIGKVISPelLHRTDLDPEVWDGSVGGELNLYGVKlDLKRIDVPEWAASeEELRERLDKAE 610

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  220 KASTEATELLQNIRQAKERAERELEKLHNRE-DSSEGIKKKLVEAEELEEKHREAQVSAQH-LEVHLKQKEQH---YEEK 294
Cdd:pfam12128  611 EALQSAREKQAAAEEQLVQANGELEKASREEtFARTALKNARLDLRRLFDEKQSEKDKKNKaLAERKDSANERlnsLEAQ 690

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  295 IKVLDNQIKKDLA--DKESLENMMQRHEeeahekgkilsEQKAMINAMDSKIRSLEQRIVELSEANKlAANSSLFTQ--R 370
Cdd:pfam12128  691 LKQLDKKHQAWLEeqKEQKREARTEKQA-----------YWQVVEGALDAQLALLKAAIAARRSGAK-AELKALETWykR 758

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  371 NMKAQ---EEMISELRQQKFYLETqagKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLT 447
Cdd:pfam12128  759 DLASLgvdPDVIAKLKREIRTLER---KIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAISELQQQLARLIA 835

                          570       580       590
                   ....*....|....*....|....*....|.
gi 1039770408  448 ELQLSLQERESQLTALQAARAALESQLRQAK 478
Cdd:pfam12128  836 DTKLRRAKLEMERKASEKQQVRLSENLRGLR 866
C1_aPKC cd20794
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ...
 943-991 7.39e-05

protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain one C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410344  Cd Length: 55  Bit Score: 41.87  E-value: 7.39e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039770408  943 RFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 991
Cdd:cd20794      9 RFN-----RRAVCAYCSDRIwGLGRQGYKCINCKLLVHKKCHKLVKVACG 53
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
230-476 7.57e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.32  E-value: 7.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  230 QNIRQAKERAERELEKLhnrEDSSEGIKKKLVEAEELEEKHREaqvsaQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADK 309
Cdd:COG3206    164 QNLELRREEARKALEFL---EEQLPELRKELEEAEAALEEFRQ-----KNGLVDLSEEAKLLLQQLSELESQLAEARAEL 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  310 ESLENMMQRHEEEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEanKLAANSSLFTQRN--MKAQEEMISELRQQkf 387
Cdd:COG3206    236 AEAEARLAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEA--ELAELSARYTPNHpdVIALRAQIAALRAQ-- 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  388 yletqagkLEAQNRKLEEQLEkishqdhsdkSRLLELETRLREVSLEHEEQKLELKRqltelqlsLQERESQLTALQAAR 467
Cdd:COG3206    307 --------LQQEAQRILASLE----------AELEALQAREASLQAQLAQLEARLAE--------LPELEAELRRLEREV 360


                   ....*....
gi 1039770408  468 AALESQLRQ 476
Cdd:COG3206    361 EVARELYES 369
PRK12704 PRK12704
phosphodiesterase; Provisional
 185-328 7.63e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 47.47  E-value: 7.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  185 DQGKPEVGEYSKLEKINAEQqlKIQELQEKLEKAVKAST-EATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEA 263
Cdd:PRK12704    45 EEAKKEAEAIKKEALLEAKE--EIHKLRNEFEKELRERRnELQKLEKRLLQKEENLDRKLELLEKREEELEKKEKELEQK 122

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770408  264 EE-LEEKHREAQVSAQHLEVHLKQ-----KEQHYEEKIKVLDNQIKKDLAdkesleNMMQRHEEEAHEKGK 328
Cdd:PRK12704   123 QQeLEKKEEELEELIEEQLQELERisgltAEEAKEILLEKVEEEARHEAA------VLIKEIEEEAKEEAD 187
PH_MRCK cd01243
MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK ...
 1026-1141 7.66e-05

MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK is thought to be coincidence detector of signaling by Cdc42 and phosphoinositides. It has been shown to promote cytoskeletal reorganization, which affects many biological processes. There are 2 members of this family: MRCKalpha and MRCKbeta. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. The MRCK PH domain is responsible for its targeting to cell to cell junctions. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269949  Cd Length: 135  Bit Score: 44.21  E-value: 7.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408 1026 EGWMKVPrnnKRG--QQGWDRKYIVLEGSKVLIYD-NEAREAGQRPVEEFELCLPDGDVSIhGAVGASELANTAKADVPY 1102
Cdd:cd01243     15 EGYVRVP---KPGgvKKGWQRQFAVVCDFKLFLFDiSEDKASQPSQVASQVLDMRDEEFSV-SSVLASDVIHANKKDIPC 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039770408 1103 ILKME-SHPHTTCWPGRTLyLLAPSFPDKQRWVTALESVV 1141
Cdd:cd01243     91 IFRVSaSQLAPPSLKFSLL-MLADSENEKQKWVDALNELH 129
mukB PRK04863
chromosome partition protein MukB;
427-763 7.76e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 47.64  E-value: 7.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  427 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKF 506
Cdd:PRK04863   283 VHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNL--------VQTALRQQEKIERYQ 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  507 DALrnsctviTDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEI------VQLRSEVDHLRREITEREMQLTSQKQ 580
Cdd:PRK04863   355 ADL-------EELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELksqladYQQALDVQQTRAIQYQQAVQALERAK 427

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  581 AQLSAPDLqTMEALKTtctMLEEQVLDLEALNDELLEKERQWeawrSVLGDEKSQFECRVRELQRMLDTEKQSRAR--AD 658
Cdd:PRK04863   428 QLCGLPDL-TADNAED---WLEEFQAKEQEATEELLSLEQKL----SVAQAAHSQFEQAYQLVRKIAGEVSRSEAWdvAR 499

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  659 QRITESRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 736
Cdd:PRK04863   500 ELLRRLREQRHLAEQLQqlRMRLSELEQRLRQQQ-RAERL---LAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVS 575

                          330       340
                   ....*....|....*....|....*..
gi 1039770408  737 KLQQQMDLQKNHIFRLTQGLQEALDRA 763
Cdd:PRK04863   576 EARERRMALRQQLEQLQARIQRLAARA 602
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
640-894 8.24e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.60  E-value: 8.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  640 VRELqrMLDtEKQSRARAD------QRITESRQVVELAVKEHKA--EILALQQALKEQKLKAESLSDKLNDLEKKHAMLE 711
Cdd:COG4913    213 VREY--MLE-EPDTFEAADalvehfDDLERAHEALEDAREQIELlePIRELAERYAAARERLAELEYLRAALRLWFAQRR 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  712 MNArsLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA-LDRADLLKTERSDLEYQLENIqvlyshekvk 790
Cdd:COG4913    290 LEL--LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEER---------- 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  791 mEGTISQQTKLIDFLQAKMDQPAKkkkGLFSRRKEDPALPTQVPLQYNELKLALekekarcAELEEALQKTRIELRSARE 870
Cdd:COG4913    358 -ERRRARLEALLAALGLPLPASAE---EFAALRAEAAALLEALEEELEALEEAL-------AEAEAALRDLRRELRELEA 426

                          250       260
                   ....*....|....*....|....
gi 1039770408  871 EAAHRKATDHPHPSTPATARQQIA 894
Cdd:COG4913    427 EIASLERRKSNIPARLLALRDALA 450
C1_Munc13-1 cd20858
protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; ...
 940-990 8.30e-05

protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; Munc13-1, also called protein unc-13 homolog A (Unc13A), is a diacylglycerol (DAG) receptor that plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Loss of MUNC13-1 function causes microcephaly, cortical hyperexcitability, and fatal myasthenia. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410408  Cd Length: 60  Bit Score: 42.00  E-value: 8.30e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770408  940 IPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 990
Cdd:cd20858      6 TPHNFEVWTATTPTYCYECEGLLwGIARQGMRCTECGVKCHEKCQDLLNADC 57
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 658-815 8.54e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.69  E-value: 8.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  658 DQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLEterELKQRLLE---- 733
Cdd:COG1579     16 DSELDRLEH----RLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIK---KYEEQLGNvrnn 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  734 -EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQP 812
Cdd:COG1579     89 kEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168


                   ...
gi 1039770408  813 AKK 815
Cdd:COG1579    169 AAK 171
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 205-529 8.84e-05

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 46.98  E-value: 8.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  205 QLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSE-GIKKKLVEAEEL--EEKHREAQVSAqhLE 281
Cdd:pfam19220   47 KSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVARLAKLEaALREAEAAKEELriELRDKTAQAEA--LE 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  282 VHLKQ---KEQHYEEKIKVLDNQIK---KDLADKES-LENMMQRH---EEEAHEKGKILSEQKAMINAMDSKIRSLEQRI 351
Cdd:pfam19220  125 RQLAAeteQNRALEEENKALREEAQaaeKALQRAEGeLATARERLallEQENRRLQALSEEQAAELAELTRRLAELETQL 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  352 ------VELSEANKLAANSSlfTQRNMKAQEEMISELRQQKfylETQAGKLEAQNRKLE--EQLekishqdhsdksrLLE 423
Cdd:pfam19220  205 datrarLRALEGQLAAEQAE--RERAEAQLEEAVEAHRAER---ASLRMKLEALTARAAatEQL-------------LAE 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  424 LETRLRevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRdeiq 503
Cdd:pfam19220  267 ARNQLR----DRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQRARAELEERAEMLTKALAAKD---- 338

                          330       340
                   ....*....|....*....|....*.
gi 1039770408  504 rkfDALRNSCTVITDLEEQLNQLTED 529
Cdd:pfam19220  339 ---AALERAEERIASLSDRIAELTKR 361
PRK09039 PRK09039
peptidoglycan -binding protein;
564-701 1.14e-04

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 46.11  E-value: 1.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  564 LRREITEREMQLtSQKQAQLSapDLQTMEAL-KTTCTMLEEQVLDLEA-LNDELLEKERqWEAWRSVLGDEKSQFECRVR 641
Cdd:PRK09039    44 LSREISGKDSAL-DRLNSQIA--ELADLLSLeRQGNQDLQDSVANLRAsLSAAEAERSR-LQALLAELAGAGAAAEGRAG 119

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770408  642 ELQRMLDTEKQSRARADQRITE-SRQVVELavkehKAEILALQQAL-------KEQKLKAESLSDKLN 701
Cdd:PRK09039   120 ELAQELDSEKQVSARALAQVELlNQQIAAL-----RRQLAALEAALdasekrdRESQAKIADLGRRLN 182
C1_nPKC_theta-like_rpt2 cd20837
second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) ...
 942-990 1.18e-04

second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410387  Cd Length: 50  Bit Score: 41.27  E-value: 1.18e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039770408  942 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATC 990
Cdd:cd20837      1 HRFKVYNYMSPTFCDHC-GSLLWGlfRQGLKCEECGMNVHHKCQKKVANLC 50
C1_aPKC_iota cd21094
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ...
 942-993 1.28e-04

protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) iota type; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain C1 domain found in aPKC isoform iota. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410447  Cd Length: 55  Bit Score: 41.14  E-value: 1.28e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039770408  942 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGLP 993
Cdd:cd21094      3 HTFQAKRFNRRAHCAICTDRIwGLGRQGYKCINCKLLVHKKCHKLVTIECGRH 55
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
211-475 1.46e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.55  E-value: 1.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  211 LQEKLEKAVKASTEATELLQNIRQAKERAERELEKLhnredssegikkklveaeeleekhreaqvSAQHLEVHLKQKEQH 290
Cdd:COG3206    166 LELRREEARKALEFLEEQLPELRKELEEAEAALEEF-----------------------------RQKNGLVDLSEEAKL 216

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  291 YEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEanKLAANSSLFTQR 370
Cdd:COG3206    217 LLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEA--ELAELSARYTPN 289

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  371 N--MKAQEEMISELRQQkfyLETQAGKLEAQnrkLEEQLEKISHQDHSDKSRLLELETRLREVSlEHEEQKLELKRQLTE 448
Cdd:COG3206    290 HpdVIALRAQIAALRAQ---LQQEAQRILAS---LEAELEALQAREASLQAQLAQLEARLAELP-ELEAELRRLEREVEV 362

                          250       260
                   ....*....|....*....|....*..
gi 1039770408  449 LQLSLQERESQLTALQAARAALESQLR 475
Cdd:COG3206    363 ARELYESLLQRLEEARLAEALTVGNVR 389
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 550-743 1.72e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 1.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  550 ANDEIVQLRSEVDHLRREITEREMQLtSQKQAQLSapdlQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVL 629
Cdd:COG3883     14 ADPQIQAKQKELSELQAELEAAQAEL-DALQAELE----ELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREEL 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  630 GDeksqfecRVRELQR------MLDTEKQSRARAD--QRITESRQVVElavkeHKAEILALQQALKEQ-KLKAESLSDKL 700
Cdd:COG3883     89 GE-------RARALYRsggsvsYLDVLLGSESFSDflDRLSALSKIAD-----ADADLLEELKADKAElEAKKAELEAKL 156

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1039770408  701 NDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 743
Cdd:COG3883    157 AELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLA 199
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
539-783 1.88e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.16  E-value: 1.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  539 YLSKQLDEASGANDEIVQ-LRSEVDHLRREITEREMQLTS-QKQAQLSAPDLQTMEALKTTcTMLEEQVLDLEAlndELL 616
Cdd:COG3206    161 YLEQNLELRREEARKALEfLEEQLPELRKELEEAEAALEEfRQKNGLVDLSEEAKLLLQQL-SELESQLAEARA---ELA 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  617 EKERQWEAWRSVLGDEKSQF-----ECRVRELQRMLDTEKQSRARADQRITE-SRQVVELavkehKAEILALQQALKEQK 690
Cdd:COG3206    237 EAEARLAALRAQLGSGPDALpellqSPVIQQLRAQLAELEAELAELSARYTPnHPDVIAL-----RAQIAALRAQLQQEA 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  691 LKAeslsdkLNDLEKKHAMLEMNARSLQQKLEterELKQRLLEEQAKLQQQMDLQKNhIFRLTQGLQEALDRADLLKTER 770
Cdd:COG3206    312 QRI------LASLEAELEALQAREASLQAQLA---QLEARLAELPELEAELRRLERE-VEVARELYESLLQRLEEARLAE 381

                          250
                   ....*....|...
gi 1039770408  771 SdleYQLENIQVL 783
Cdd:COG3206    382 A---LTVGNVRVI 391
C1_MTMR-like cd20828
protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to ...
 938-991 1.93e-04

protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to myotubularin-related proteins; The family includes a group of uncharacterized proteins that show high sequence similarity to vertebrate myotubularin-related proteins (MTMRs), such as MTMR5 and MTMR13. MTMRs may function as guanine nucleotide exchange factors (GEFs). Vertebrate MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Members of this family contain these domains and have an additional C1 domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410378  Cd Length: 57  Bit Score: 40.89  E-value: 1.93e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039770408  938 HNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 991
Cdd:cd20828      2 FTQPHNFEPHSFVTPTNCDYCLQILwGIVKKGMKCSECGYNCHEKCQPQVPKQCS 56
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
207-476 2.21e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 2.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  207 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNRED-SSEGIKKKLVEAE--ELEEKHREAQVSAQHLEvH 283
Cdd:COG4913    611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEySWDEIDVASAEREiaELEAELERLDASSDDLA-A 689

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  284 LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEahekgkilseqkaminamdskIRSLEQRIVELSEANKLAAN 363
Cdd:COG4913    690 LEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEE---------------------LDELQDRLEAAEDLARLELR 748

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  364 SSLFTQRNMKAQEEMISELRQQkfyLETQAGKLEAQNRKLEEQLEKI----SHQDHSDKSRL----------LELETRLR 429
Cdd:COG4913    749 ALLEERFAAALGDAVERELREN---LEERIDALRARLNRAEEELERAmrafNREWPAETADLdadleslpeyLALLDRLE 825

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1039770408  430 EVSL-EHEEQkleLKRQLTElqLSLQERESQLTALQAARAALESQLRQ 476
Cdd:COG4913    826 EDGLpEYEER---FKELLNE--NSIEFVADLLSKLRRAIREIKERIDP 868
C1_PKD2_rpt2 cd20843
second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and ...
 940-990 2.80e-04

second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins; PKD2, also called PRKD2, HSPC187, or serine/threonine-protein kinase D2 (nPKC-D2), is a serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. PKD2 contains N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410393  Cd Length: 79  Bit Score: 41.11  E-value: 2.80e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770408  940 IPHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 990
Cdd:cd20843     10 VPHTFVIHSYTRPTVCQFCKKLLKgLFRQGLQCKDCKFNCHKRCATRVPNDC 61
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 171-464 3.11e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.50  E-value: 3.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  171 LHKMQGHAGLTSAKDQGKPEVGEYSKLEKiNAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERA----ERELEKL 246
Cdd:pfam17380  275 LHIVQHQKAVSERQQQEKFEKMEQERLRQ-EKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMamerERELERI 353

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  247 hnredssegikkklveaeELEEKHREAQvsaqhlevHLKQKEQHYE-EKIKVLDNqikkdLADKESLENMMQRHEEEAHE 325
Cdd:pfam17380  354 ------------------RQEERKRELE--------RIRQEEIAMEiSRMRELER-----LQMERQQKNERVRQELEAAR 402

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  326 KGKILSEQKAminamdskiRSLEQRIVELSEANKLAANSSlftQRNMKAQEEMISElrqqkfylETQAGKLEAQNRklEE 405
Cdd:pfam17380  403 KVKILEEERQ---------RKIQQQKVEMEQIRAEQEEAR---QREVRRLEEERAR--------EMERVRLEEQER--QQ 460

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770408  406 QLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 464
Cdd:pfam17380  461 QVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLE 519
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 447-777 3.28e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 45.27  E-value: 3.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  447 TELQLSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeiqaltahRDEIQRKFDALRNSctvITDLEEQLNQL 526
Cdd:pfam07888   34 NRLEECLQERAELLQAQEAANRQREKEKERYKRD------------------REQWERQRRELESR---VAELKEELRQS 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  527 TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQAQLSAPDLQTMEALKTTCTMLEEQV- 605
Cdd:pfam07888   93 REKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAe 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  606 -----LDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRARADQRITESRQVvelavkehKAEIL 680
Cdd:pfam07888  173 rkqlqAKLQQTEEELRSLSKEFQELRNSLAQRDTQ----VLQLQDTITTLTQKLTTAHRKEAENEAL--------LEELR 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  681 ALQQALKEQKLKAESLSDKLNDL--EKKHAMLEMNARSLQ------QKLETE---RELKQRLLEEQAKLQQQMDLQKNHI 749
Cdd:pfam07888  241 SLQERLNASERKVEGLGEELSSMaaQRDRTQAELHQARLQaaqltlQLADASlalREGRARWAQERETLQQSAEADKDRI 320

                          330       340
                   ....*....|....*....|....*...
gi 1039770408  750 FRLTQGLQEALDRADLLKTERSDLEYQL 777
Cdd:pfam07888  321 EKLSAELQRLEERLQEERMEREKLEVEL 348
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 192-313 3.34e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.15  E-value: 3.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  192 GEYSKLEKINAEQQLKIQELQEKLEKAvkasteaTELLQNIRQAKE--RAERELEKLHNR-EDSSEGIKKKLVEAEELEE 268
Cdd:COG1579     52 TELEDLEKEIKRLELEIEEVEARIKKY-------EEQLGNVRNNKEyeALQKEIESLKRRiSDLEDEILELMERIEELEE 124

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1039770408  269 KHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLE 313
Cdd:COG1579    125 ELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELA 169
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 208-343 3.40e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 45.59  E-value: 3.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  208 IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSS-----EGIKKKLVEA-EELEEKHREAQVSAQhlE 281
Cdd:PRK00409   522 IASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLleeaeKEAQQAIKEAkKEADEIIKELRQLQK--G 599

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770408  282 VHLKQKEQHYEEKIKVLDNQIKKdlADKESLENMMQRHEEEAHEKGKILS-EQKAMINAMDSK 343
Cdd:PRK00409   600 GYASVKAHELIEARKRLNKANEK--KEKKKKKQKEKQEELKVGDEVKYLSlGQKGEVLSIPDD 660
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 194-776 3.71e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 45.12  E-value: 3.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  194 YSKLEKINAEQQLKIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEE-LEEKHRE 272
Cdd:pfam05557    6 ESKARLSQLQNEKKQMELEHKRARI--------ELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEaLREQAEL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  273 AQVSAQHLEVHLKQKEQHY--EEKIKVLDNQIKKDLAD-KESLENMMQRHEEEAHEKGKI---LSEQKAMINAMDSKIRS 346
Cdd:pfam05557   78 NRLKKKYLEALNKKLNEKEsqLADAREVISCLKNELSElRRQIQRAELELQSTNSELEELqerLDLLKAKASEAEQLRQN 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  347 L----------EQRIVELSEANKLAANSSLFTqRNMKAQEEMISElrqqkfyLETQAGKLEAQNRKLEEQLEKIS---HQ 413
Cdd:pfam05557  158 LekqqsslaeaEQRIKELEFEIQSQEQDSEIV-KNSKSELARIPE-------LEKELERLREHNKHLNENIENKLllkEE 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  414 DHSDKSRLLELE-TRLREVSLEHEEQKLELKrqLTELQLSLQERESQLTALQAARAALEsQLRQAKTELEETTAEAEEEI 492
Cdd:pfam05557  230 VEDLKRKLEREEkYREEAATLELEKEKLEQE--LQSWVKLAQDTGLNLRSPEDLSRRIE-QLQQREIVLKEENSSLTSSA 306

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  493 QALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDeasgandeivQLRSEVDHLRREITERE 572
Cdd:pfam05557  307 RQLEKARRELEQELAQYLKK---IEDLNKKLKRHKALVRRLQRRVLLLTKERD----------GYRAILESYDKELTMSN 373

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  573 mqlTSQKQaqlsapdLQTMEAlkttctmLEEQVLDLEALNDELlekerqweawrsvlgdeksqfECRVRELQRMLDTEKQ 652
Cdd:pfam05557  374 ---YSPQL-------LERIEE-------AEDMTQKMQAHNEEM---------------------EAQLSVAEEELGGYKQ 415

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  653 SRARADQRITESRQVVELA-VKEHKAEILALQQALKEQKLKAESLSDKLNDLEkkhamLEMNARSLQQKLETER------ 725
Cdd:pfam05557  416 QAQTLERELQALRQQESLAdPSYSKEEVDSLRRKLETLELERQRLREQKNELE-----MELERRCLQGDYDPKKtkvlhl 490

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770408  726 ------ELKQRLLEEQAKLQQQMDLQKnhifRLTQGLQEALDRADLLKTERSDLEYQ 776
Cdd:pfam05557  491 smnpaaEAYQQRKNQLEKLQAEIERLK----RLLKKLEDDLEQVLRLPETTSTMNFK 543
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 514-742 4.02e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.82  E-value: 4.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  514 TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG----ANDEIVQLRSEVDHLRREITEREMQLtSQKQAQLSApDLQ 589
Cdd:COG3883     16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEeyneLQAELEALQAEIDKLQAEIAEAEAEI-EERREELGE-RAR 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  590 TMEALKTTCTMLEeQVLDLEALNDELlekeRQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVE 669
Cdd:COG3883     94 ALYRSGGSVSYLD-VLLGSESFSDFL----DRLSALSKIADADADLLE-ELKADKAELEAKKAELEAKLAELEALKAELE 167

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770408  670 LAVKEhkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM 742
Cdd:COG3883    168 AAKAE-------LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233
C1_Munc13-2-like cd20859
protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar ...
 936-990 4.20e-04

protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins; Munc13-2, also called protein unc-13 homolog B (Unc13B), plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410409  Cd Length: 82  Bit Score: 40.82  E-value: 4.20e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770408  936 MHHNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 990
Cdd:cd20859     14 ISCTTPHNFEVWTATTPTYCYECEGLLwGIARQGMRCSECGVKCHEKCQDLLNADC 69
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 197-531 4.76e-04

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 44.68  E-value: 4.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  197 LEKINAEQQLKIQELQeklekavKASTEATELLQNIRQAKERAEReLEKLhnrEDSSEGIKKKL---------VEAEE-- 265
Cdd:pfam05622   92 LEKEVLELQHRNEELT-------SLAEEAQALKDEMDILRESSDK-VKKL---EATVETYKKKLedlgdlrrqVKLLEer 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  266 ----------LEEKHREAQVSAQHLEVHLKQ-KEQHyeekiKVLDNQIKKdlADKESLE--NMMQRHEEEAHEKGKILSE 332
Cdd:pfam05622  161 naeymqrtlqLEEELKKANALRGQLETYKRQvQELH-----GKLSEESKK--ADKLEFEykKLEEKLEALQKEKERLIIE 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  333 QKAMINAMDS-KIRSLEQRivELSEANKLAANSSLfTQRNMkAQEEMISELRQQKFYLETQAGKL-EAQNRKLEEQLEKI 410
Cdd:pfam05622  234 RDTLRETNEElRCAQLQQA--ELSQADALLSPSSD-PGDNL-AAEIMPAEIREKLIRLQHENKMLrLGQEGSYRERLTEL 309

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  411 SHQDHSDKSRLLELETRLRevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaEAEE 490
Cdd:pfam05622  310 QQLLEDANRRKNELETQNR----LANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLEKLH--------EAQS 377

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1039770408  491 EIQALTAHRDEIQRKFDAlrNSCTVITDLEEQLNQLTEDNA 531
Cdd:pfam05622  378 ELQKKKEQIEELEPKQDS--NLAQKIDELQEALRKKDEDMK 416
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 238-615 5.05e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 44.94  E-value: 5.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  238 RAERE--LEKLHnredssegikkklVEAEELEEKHREA---------------QVSAQHLEVHLkqkEQHYEEKIKVLDN 300
Cdd:COG3096    780 RAAREkrLEELR-------------AERDELAEQYAKAsfdvqklqrlhqafsQFVGGHLAVAF---APDPEAELAALRQ 843

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  301 QIKKDLADKESLENMMQRHEEEAHEkgkiLSEQKAMINAMDSKI-----RSLEQRIVELSEANKLAANSSLFTQRNMKAQ 375
Cdd:COG3096    844 RRSELERELAQHRAQEQQLRQQLDQ----LKEQLQLLNKLLPQAnlladETLADRLEELREELDAAQEAQAFIQQHGKAL 919

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  376 ---EEMIS----------ELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLL----ELETRLREVSLEHEEQ 438
Cdd:COG3096    920 aqlEPLVAvlqsdpeqfeQLQADYLQAKEQQRRLKQQIFALSEVVQRRPHFSYEDAVGLLgensDLNEKLRARLEQAEEA 999

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  439 KLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA-HRDEIQRKFDALRNSCtviT 517
Cdd:COG3096   1000 RREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELEQELEELGVQADAEAEERARiRRDELHEELSQNRSRR---S 1076

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  518 DLEEQLnQLTEdnAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITER--EMQLTSQKQAQLSAPDLQTM--EA 593
Cdd:COG3096   1077 QLEKQL-TRCE--AEMDSLQKRLRKAERDYKQEREQVVQAKAGWCAVLRLARDNdvERRLHRRELAYLSADELRSMsdKA 1153

                          410       420
                   ....*....|....*....|..
gi 1039770408  594 LKTtctmLEEQVLDLEALNDEL 615
Cdd:COG3096   1154 LGA----LRLAVADNEHLRDAL 1171
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 33-478 5.42e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 44.71  E-value: 5.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   33 ELKASETQRSLLEQDLATYITECSSLKRSlEQARMEVSQEDDKALQLlhDIREQSRKLQEIKEQEYQAQVEemrlmmnqL 112
Cdd:pfam05483  339 ELNKAKAAHSFVVTEFEATTCSLEELLRT-EQQRLEKNEDQLKIITM--ELQKKSSELEEMTKFKNNKEVE--------L 407

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  113 EE-DLVSARRRSDLYESELRESrlAAEEFKRKANECQHKLMkvvshpprgdsggTALDDLHKMQGHAGLTSAKDQgkpev 191
Cdd:pfam05483  408 EElKKILAEDEKLLDEKKQFEK--IAEELKGKEQELIFLLQ-------------AREKEIHDLEIQLTAIKTSEE----- 467

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  192 gEYSKlekinaeqqlKIQELQEKLEKAVKASTEATE-----LLQNIRQAKERAERELEKLHNREDSSEGIKKK---LVEA 263
Cdd:pfam05483  468 -HYLK----------EVEDLKTELEKEKLKNIELTAhcdklLLENKELTQEASDMTLELKKHQEDIINCKKQEermLKQI 536

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  264 EELEEKhreaqvsaqhlEVHLKQKEQHYEEKIKVLDNQIKKDLADKEslENmMQRHEEEAHEKGKILSEQKAMINAMDSK 343
Cdd:pfam05483  537 ENLEEK-----------EMNLRDELESVREEFIQKGDEVKCKLDKSE--EN-ARSIEYEVLKKEKQMKILENKCNNLKKQ 602

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  344 IRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELR------QQKFYLETQAGKLEAQNRKLEEQ--LEKISH-QD 414
Cdd:pfam05483  603 IENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLElelasaKQKFEEIIDNYQKEIEDKKISEEklLEEVEKaKA 682

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  415 HSDKSRLLELETRLR------EVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 478
Cdd:pfam05483  683 IADEAVKLQKEIDKRcqhkiaEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIK 752
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 227-523 5.49e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 44.50  E-value: 5.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  227 ELLQNIRQAKERAERELEKLHNREDSSEGIKKK----LVEAEELEEKHREAQVSAQHLEVHLKQKEQHYE---EKIKVLD 299
Cdd:pfam07888   84 ELKEELRQSREKHEELEEKYKELSASSEELSEEkdalLAQRAAHEARIRELEEDIKTLTQRVLERETELErmkERAKKAG 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  300 NQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSeaNKLAAnsslfTQRNMKAQEEMI 379
Cdd:pfam07888  164 AQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLT--QKLTT-----AHRKEAENEALL 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  380 SELRQQKFYLETQAGKLEAQNRKLEEQlekISHQDHS----DKSRL--LELETRLREVSLEHEEQKLELKRQLTELQLSL 453
Cdd:pfam07888  237 EELRSLQERLNASERKVEGLGEELSSM---AAQRDRTqaelHQARLqaAQLTLQLADASLALREGRARWAQERETLQQSA 313

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  454 QERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQL 523
Cdd:pfam07888  314 EADKDRIEKLSAELQRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASLRVAQKEKEQL 383
PRK12704 PRK12704
phosphodiesterase; Provisional
 232-401 5.60e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.38  E-value: 5.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  232 IRQAKERAERELEklhNREDSSEGIKK-KLVEA--------EELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvldnqi 302
Cdd:PRK12704    33 IKEAEEEAKRILE---EAKKEAEAIKKeALLEAkeeihklrNEFEKELRERRNELQKLEKRLLQKEENLDR--------- 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  303 KKDLADKEslENMMQRHEEEAHEKGKILSEQKAMInamDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISEL 382
Cdd:PRK12704   101 KLELLEKR--EEELEKKEKELEQKQQELEKKEEEL---EELIEEQLQELERISGLTAEEAKEILLEKVEEEARHEAAVLI 175

                          170
                   ....*....|....*....
gi 1039770408  383 RQqkfyLETQAgKLEAQNR 401
Cdd:PRK12704   176 KE----IEEEA-KEEADKK 189
46 PHA02562
endonuclease subunit; Provisional
 648-807 5.80e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.62  E-value: 5.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  648 DTEKQSRARADQRITESRQVVELAVKE---HKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ------ 718
Cdd:PHA02562   202 KNIEEQRKKNGENIARKQNKYDELVEEaktIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmy 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  719 ----------QKLETERELKQRLLEEQAKLQQQMDLQKNHIfrltQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEk 788
Cdd:PHA02562   282 ekggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAI----DELEEIMDEFNEQSKKLLELKNKISTNKQSLITL- 356

                          170
                   ....*....|....*....
gi 1039770408  789 vkmEGTISQQTKLIDFLQA 807
Cdd:PHA02562   357 ---VDKAKKVKAAIEELQA 372
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
195-508 5.93e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.12  E-value: 5.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  195 SKLEKINAEQQL---KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNredssegikkklvEAEELEEKHR 271
Cdd:COG4372     66 EELEQARSELEQleeELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQK-------------ERQDLEQQRK 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  272 EAQVSAQHLEVHLKQKEqhyeEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRI 351
Cdd:COG4372    133 QLEAQIAELQSEIAERE----EELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKL 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  352 VELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREV 431
Cdd:COG4372    209 IESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEAL 288

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039770408  432 SLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDA 508
Cdd:COG4372    289 EEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEA 365
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 5-277 5.94e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 44.67  E-value: 5.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLatyitECSSLKRSLEQARMEVSQEDDKALQLLHDIR 84
Cdd:TIGR02169  778 EEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKL-----NRLTLEKEYLEKEIQELQEQRIDLKEQIKSI 852

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   85 EQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKvvshppRGDSG 164
Cdd:TIGR02169  853 EKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSE------LKAKL 926

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  165 GTALDDLhkmqghAGLTSAKDQGKPEVGEYSKLEKInaeqQLKIQELQEKLEKAVKASTEAtellqnIRQAKERAER--E 242
Cdd:TIGR02169  927 EALEEEL------SEIEDPKGEDEEIPEEELSLEDV----QAELQRVEEEIRALEPVNMLA------IQEYEEVLKRldE 990

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1039770408  243 LEKLHNR-EDSSEGIKKKLveaEELEEKHREAQVSA 277
Cdd:TIGR02169  991 LKEKRAKlEEERKAILERI---EEYEKKKREVFMEA 1023
C1_dGM13116p-like cd20831
protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and ...
 953-990 6.79e-04

protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and similar proteins; This group contains uncharacterized proteins including Drosophila melanogaster GM13116p and Caenorhabditis elegans hypothetical protein R11G1.4, both of which contain C2 (a calcium-binding domain) and C1 domains. This model describes the C1 domain, a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410381  Cd Length: 58  Bit Score: 39.25  E-value: 6.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039770408  953 TKCAVCLDTV--HFGRQASKCLECQVMCHPKCSTCLPATC 990
Cdd:cd20831     17 PSCAVCNKLIpgRFGKQGYQCRDCGLICHKRCHVKVETHC 56
ATG17_like pfam04108
Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ...
 215-478 7.10e-04

Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ATG17 and ATG11, conserved across eukaryotes. ATG17 forms a complex with ATG29 and ATG31, critical for both PAS (preautophagosomal structure) formation and autophagy. Together with ATG13, it is required for ATG1 kinase activation. ATG11 is a scaffold protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway during starvation and to recruit ATG proteins to the pre-autophagosome. It is also required for ATG1 kinase activation. In many eukaryotes, ATG11 (the orthologue in mammals is RB1-inducible coiled-coil protein 1 (RB1CC1) and in S. pombe is Taz1-interacting factor 1 (taf1)) is essential for bulk autophagy, except in S.cerevisiae. ATG17 and ATG11 are large similar proteins, both predicted to be almost entirely helical, containing conserved coiled-coil regions and lack obvious functional motifs.


Pssm-ID: 427715 [Multi-domain]  Cd Length: 360  Bit Score: 43.92  E-value: 7.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  215 LEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVE-AEELEEKHREAQVSAQHLEVHLKQKEQHYEE 293
Cdd:pfam04108    2 LSSAQDLCRWANELLTDARSLLEELVVLLAKIAFLRRGLSVQLANLEKvREGLEKVLNELKKDFKQLLKDLDAALERLEE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  294 KIKVLDNQI------------KK--DLADKESLENM---MQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSE 356
Cdd:pfam04108   82 TLDKLRNTPvepalppgeekqKTllDFIDEDSVEILrdaLKELIDELQAAQESLDSD---LKRFDDDLRDLQKELESLSS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  357 ANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHE 436
Cdd:pfam04108  159 PSESISLIPTLLKELESLEEEMASLLESLTNHYDQCVTAVKLTEGGRAEMLEVLENDARELDDVVPELQDRLDEMENNYE 238

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1039770408  437 ------EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 478
Cdd:pfam04108  239 rlqkllEQKNSLIDELLSALQLIAEIQSRLPEYLAALKEFEERWEEEK 286
46 PHA02562
endonuclease subunit; Provisional
 354-574 8.03e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.85  E-value: 8.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  354 LSEANKLaaNSSLftqrnMKAQEEMISELRQQKFYLETQagkLEAQNRKLEEQlEKISHQDHSDKSrllELETRLREVSL 433
Cdd:PHA02562   165 LSEMDKL--NKDK-----IRELNQQIQTLDMKIDHIQQQ---IKTYNKNIEEQ-RKKNGENIARKQ---NKYDELVEEAK 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  434 EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK--------------------------TELEETTAE 487
Cdd:PHA02562   231 TIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmyekggvcptctqqisegpdriTKIKDKLKE 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  488 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGA----NDEIVQLRSEVDH 563
Cdd:PHA02562   311 LQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEfvdnAEELAKLQDELDK 390

                          250
                   ....*....|.
gi 1039770408  564 LRREITEREMQ 574
Cdd:PHA02562   391 IVKTKSELVKE 401
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 6-299 8.21e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 43.73  E-value: 8.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    6 EAMMEQEmTRLHRRVSEVEAVLSQKevelKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIRE 85
Cdd:pfam07888  143 QRVLERE-TELERMKERAKKAGAQR----KEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITT 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   86 QSRKLQEIKEQEyqAQVEEMRLMMNQLEEDLVSARRRSDLYESELREsrlaaeefkrkanecqhklmkvvshpprgdsgg 165
Cdd:pfam07888  218 LTQKLTTAHRKE--AENEALLEELRSLQERLNASERKVEGLGEELSS--------------------------------- 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  166 talddlhkmqghagLTSAKDQGKPEVGEySKLEKINAEQQLKIQELQEKLEKAvKASTEATELLQNIRQAKERAER---E 242
Cdd:pfam07888  263 --------------MAAQRDRTQAELHQ-ARLQAAQLTLQLADASLALREGRA-RWAQERETLQQSAEADKDRIEKlsaE 326

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770408  243 LEKLHNR--EDSSEGIKKKLVEAEE-------LEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD 299
Cdd:pfam07888  327 LQRLEERlqEERMEREKLEVELGREkdcnrvqLSESRRELQELKASLRVAQKEKEQLQAEKQELLE 392
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 448-816 8.58e-04

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 43.91  E-value: 8.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  448 ELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiqaltahrdEIQRKFDALRNSCTVIT----DLEEQL 523
Cdd:pfam05622   11 ELAQRCHELDQQVSLLQEEKNSLQQENKKLQ----------------------ERLDQLESGDDSGTPGGkkylLLQKQL 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  524 NQLTEDN--------------AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRrEITER----EMQLTSQKQaqlsa 585
Cdd:pfam05622   69 EQLQEENfrletarddyrikcEELEKEVLELQHRNEELTSLAEEAQALKDEMDILR-ESSDKvkklEATVETYKK----- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  586 pDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTE-----------KQSR 654
Cdd:pfam05622  143 -KLEDLGDLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQ----VQELHGKLSEEskkadklefeyKKLE 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  655 A------RADQRITESRQVVELAVKE-----------HKAEILALQQALKEQKLKAESLS----DKLNDLEKKHAMLEMN 713
Cdd:pfam05622  218 EklealqKEKERLIIERDTLRETNEElrcaqlqqaelSQADALLSPSSDPGDNLAAEIMPaeirEKLIRLQHENKMLRLG 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  714 AR--------SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEniQVLYS 785
Cdd:pfam05622  298 QEgsyrerltELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLE--KLHEA 375

                          410       420       430
                   ....*....|....*....|....*....|.
gi 1039770408  786 HEKvkmegtISQQTKLIDFLQAKMDQPAKKK 816
Cdd:pfam05622  376 QSE------LQKKKEQIEELEPKQDSNLAQK 400
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 10-825 9.36e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 44.27  E-value: 9.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQarmEVSQEDDKALQLLHDIREQsrk 89
Cdd:TIGR01612  806 DEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFINFENNCKE---KIDSEHEQFAELTNKIKAE--- 879

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   90 LQEIKEQEYQAQVEEMRLMMNQ----LEEDL--VSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPPRGDS 163
Cdd:TIGR01612  880 ISDDKLNDYEKKFNDSKSLINEinksIEEEYqnINTLKKVDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIKESNL 959

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  164 ggtaLDDLHKMQGHAGLTSAKDQGKPEVGEYS--KLEKINAEQQLKIQELQEKLEKAvKAST------EATELLQNIRQA 235
Cdd:TIGR01612  960 ----IEKSYKDKFDNTLIDKINELDKAFKDASlnDYEAKNNELIKYFNDLKANLGKN-KENMlyhqfdEKEKATNDIEQK 1034

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  236 KERAERELEKLH-----NREDSSEGIKKKLVEAEELEEKH--REAQVSAQHLEvHLKQKEQHY-------EEKIKVLD-- 299
Cdd:TIGR01612 1035 IEDANKNIPNIEiaihtSIYNIIDEIEKEIGKNIELLNKEilEEAEINITNFN-EIKEKLKHYnfddfgkEENIKYADei 1113

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  300 NQIKKDLadkeslENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQrivelsEANKLAANSSLftQRNMKAQEEMI 379
Cdd:TIGR01612 1114 NKIKDDI------KNLDQKIDHHIKALEEIKKKSENYIDEIKAQINDLED------VADKAISNDDP--EEIEKKIENIV 1179

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  380 SELRQQKfYLETQAGKLEAQNRKLEE---QLEKISHQDHSDKSRLLEL-------ETRLREVSLEHEEQKLElkrQLTEL 449
Cdd:TIGR01612 1180 TKIDKKK-NIYDEIKKLLNEIAEIEKdktSLEEVKGINLSYGKNLGKLflekideEKKKSEHMIKAMEAYIE---DLDEI 1255

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  450 QLSLQERESQLTALQAARAALESqlrqakteleettaeaeeeiqaLTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTED 529
Cdd:TIGR01612 1256 KEKSPEIENEMGIEMDIKAEMET----------------------FNISHDDDKDHHIISKKHDENISDIREKSLKIIED 1313

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  530 NAELNNQNFY---LSKQLDEASGANDEIVQLRSEVDHL-------------------RREITEREMQLTSQ--------- 578
Cdd:TIGR01612 1314 FSEESDINDIkkeLQKNLLDAQKHNSDINLYLNEIANIynilklnkikkiidevkeyTKEIEENNKNIKDEldkseklik 1393

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  579 -----------KQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVL------GDEKSQFECRVR 641
Cdd:TIGR01612 1394 kikddinleecKSKIESTLDDKDIDECIKKIKELKNHILSEESNIDTYFKNADENNENVLLLfkniemADNKSQHILKIK 1473

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  642 -------------ELQRMLDTEKQSRARADQRITESRQVVELaVKEHKAEILALQQALKEQKLK---AESLSDK---LND 702
Cdd:TIGR01612 1474 kdnatndhdfninELKEHIDKSKGCKDEADKNAKAIEKNKEL-FEQYKKDVTELLNKYSALAIKnkfAKTKKDSeiiIKE 1552

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  703 LEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ----MDLQKNhifrlTQGLQEALDRADLLKTERSDLEYQLE 778
Cdd:TIGR01612 1553 IKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSnkaaIDIQLS-----LENFENKFLKISDIKKKINDCLKETE 1627

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039770408  779 NIQvlyshEKVKMEGTISQQTKL------IDFLQAKMDQPAKKKKGLFSRRKE 825
Cdd:TIGR01612 1628 SIE-----KKISSFSIDSQDTELkengdnLNSLQEFLESLKDQKKNIEDKKKE 1675
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 182-409 1.09e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  182 SAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgikkklv 261
Cdd:COG3883     13 FADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERR------- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  262 eaEELEEKHREAQVS---AQHLEVhlkqkeqhyeekikVLDNQIKKDLADKESLENMMQRHEeeahekGKILSEQKAMIN 338
Cdd:COG3883     86 --EELGERARALYRSggsVSYLDV--------------LLGSESFSDFLDRLSALSKIADAD------ADLLEELKADKA 143

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039770408  339 AMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK 409
Cdd:COG3883    144 ELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAA 214
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 234-654 1.18e-03

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 43.64  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  234 QAKERAERE-LEKLHNRedssegIKKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldNQikkDLADKESL 312
Cdd:PRK10246   418 HAEQRPLRQrLVALHGQ------IVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEK-----TQ---QLADVKTI 483

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  313 EnmmqrheeEAHEKGKILSEQKAMINAMDS--KIRSLEQRIVELSEANKLAANsslftQRNMKAQEEMISELRQQKFYLE 390
Cdd:PRK10246   484 C--------EQEARIKDLEAQRAQLQAGQPcpLCGSTSHPAVEAYQALEPGVN-----QSRLDALEKEVKKLGEEGAALR 550

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  391 tqaGKLEAqnrkLEEQLekisHQDHSDKSRLLELETRLRE----------VSL-------------EHEEQKLELKRQLT 447
Cdd:PRK10246   551 ---GQLDA----LTKQL----QRDESEAQSLRQEEQALTQqwqavcaslnITLqpqddiqpwldaqEEHERQLRLLSQRH 619

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  448 ELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQR------KFDALRNSCTVITDLEE 521
Cdd:PRK10246   620 ELQGQIAAHNQQIIQYQQQIEQRQQQLLTALAGYALTLPQEDEEASWLATRQQEAQSwqqrqnELTALQNRIQQLTPLLE 699

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  522 QLNQLTEDNAELNnqnfylSKQLDEASGANDEIVQLRSEVDHLRREITErEMQLTSQKQAQLSApdlqtmeALKTTCtmL 601
Cdd:PRK10246   700 TLPQSDDLPHSEE------TVALDNWRQVHEQCLSLHSQLQTLQQQDVL-EAQRLQKAQAQFDT-------ALQASV--F 763

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039770408  602 EEQVLDLEALNDEllEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSR 654
Cdd:PRK10246   764 DDQQAFLAALLDE--ETLTQLEQLKQNLENQRQQAQTLVTQTAQALAQHQQHR 814
C1_MRCKalpha cd20864
protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related ...
 942-995 1.38e-03

protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins; MRCK alpha, also called Cdc42-binding protein kinase alpha, DMPK-like alpha, or myotonic dystrophy protein kinase-like alpha, is a serine/threonine-protein kinase expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK alpha is an important downstream effector of Cdc42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410414  Cd Length: 60  Bit Score: 38.46  E-value: 1.38e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039770408  942 HRFNVGLNMRATKCAVCLD-TVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAE 995
Cdd:cd20864      3 HQFVVKSFTTPTKCNQCTSlMVGLIRQGCTCEVCGFSCHVTCADKAPSVCPIPPE 57
C1_TNS1_v cd20888
protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar ...
 942-989 1.44e-03

protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins; Tensin-1 (TNS1) plays a role in fibrillar adhesion formation. It may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. This model corresponds to the C1 domain found in TNS1 variant. Typical TNS1 does not contain C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410438  Cd Length: 57  Bit Score: 38.31  E-value: 1.44e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039770408  942 HRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKC-----STCLPAT 989
Cdd:cd20888      6 HTFKVKTFKKVKSCGICKQAI--TREGSTCRVCKLSCHKKCeakvaTPCVPAV 56
C1_MRCK cd20809
protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related ...
 942-993 1.45e-03

protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) family; MRCK is thought to be a coincidence detector of signaling by the small GTPase Cdc42 and phosphoinositides. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. MRCK has been shown to promote cytoskeletal reorganization, which affects many biological processes. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410359  Cd Length: 53  Bit Score: 38.02  E-value: 1.45e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039770408  942 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGLP 993
Cdd:cd20809      1 HKFIVRTFSTPTKCNHC-TSLMVGlvRQGLVCEVCGYACHVSCADKAPQVCPVP 53
COG5022 COG5022
Myosin heavy chain [General function prediction only];
208-785 1.46e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 43.53  E-value: 1.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  208 IQELQEKLEKavkasteatELLQNIRQAKERAERELEkLHNREDSSEGIKKK----------LVEAEELEEKHREAQV-- 275
Cdd:COG5022    819 IIKLQKTIKR---------EKKLRETEEVEFSLKAEV-LIQKFGRSLKAKKRfsllkketiyLQSAQRVELAERQLQElk 888

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  276 ----SAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRH--EEEAHEKGKILSEQKAMINAMDSKIRSLEQ 349
Cdd:COG5022    889 idvkSISSLKLVNLELESEIIELKKSLSSDLIENLEFKTELIARLKKLlnNIDLEEGPSIEYVKLPELNKLHEVESKLKE 968

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  350 RIVELSEANKlaANSSLFTQRNmKAQEEM------ISELRQQKFYLETQAGKLEAQNRKLEE--QLEKISHQDHSDKSRL 421
Cdd:COG5022    969 TSEEYEDLLK--KSTILVREGN-KANSELknfkkeLAELSKQYGALQESTKQLKELPVEVAElqSASKIISSESTELSIL 1045

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  422 LELEtrlrEVSLEHEEQKLELKRQLTELQLslqERESQLTalqaaraaLESQLRQAKTELEETTAEAEEEIQALTahrde 501
Cdd:COG5022   1046 KPLQ----KLKGLLLLENNQLQARYKALKL---RRENSLL--------DDKQLYQLESTENLLKTINVKDLEVTN----- 1105

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  502 iqRKFDALRNSCTVITDLEEQLNqLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQA 581
Cdd:COG5022   1106 --RNLVKPANVLQFIVAQMIKLN-LLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKRL 1182

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  582 QLSApdlqtmeALKTTCTMLEEQVLDLEalnDELLEKERQ-WEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRAR--AD 658
Cdd:COG5022   1183 YQSA-------LYDEKSKLSSSEVNDLK---NELIALFSKiFSGWPRGDKLKKLISEGWVPTEYSTSLKGFNNLNKkfDT 1252

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  659 QRITESRQVVELAVKehkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAM-----LEMNARSLQQKLETERELKQRLLE 733
Cdd:COG5022   1253 PASMSNEKLLSLLNS--------IDNLLSSYKLEEEVLPATINSLLQYINVglfnaLRTKASSLRWKSATEVNYNSEELD 1324

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770408  734 EQAKLQQQMDLQKNhifrltqgLQEALDRADLLKTERSDLEYQLENIQVLYS 785
Cdd:COG5022   1325 DWCREFEISDVDEE--------LEELIQAVKVLQLLKDDLNKLDELLDACYS 1368
C1_ScPKC1-like_rpt1 cd20822
first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ...
 937-990 1.63e-03

first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of the C1 domain. This model corresponds to the first one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410372  Cd Length: 52  Bit Score: 38.04  E-value: 1.63e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039770408  937 HHNIPHRF-NVglnmraTKCAVCLDtvHFGRQASKCLECQVMCHPKCSTCLPATC 990
Cdd:cd20822      3 HKFVQKQFyQI------MRCAVCGE--FLVNAGYQCEDCKYTCHKKCYEKVVTKC 49
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 202-464 1.94e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 42.49  E-value: 1.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  202 AEQQLKIQELQEKLEKAVKASTEATELLQNIR-QAKERAERElEKLHNREDSSEGIKKKLVEAeeLEEKhREAQVSAQHL 280
Cdd:pfam15905   52 TARKVKSLELKKKSQKNLKESKDQKELEKEIRaLVQERGEQD-KRLQALEEELEKVEAKLNAA--VREK-TSLSASVASL 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  281 EVHLKQKEQHYE-EKIKVLDNQIKKDLaDKESLENMMQRHEEEAHEKG----------------KILSEQKAMINAMDSK 343
Cdd:pfam15905  128 EKQLLELTRVNElLKAKFSEDGTQKKM-SSLSMELMKLRNKLEAKMKEvmakqegmegklqvtqKNLEHSKGKVAQLEEK 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  344 IRSLEQ-RIVELSEANKLAAnsslFTQRNMKAQEEMIS---ELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKS 419
Cdd:pfam15905  207 LVSTEKeKIEEKSETEKLLE----YITELSCVSEQVEKyklDIAQLEELLKEKNDEIESLKQSLEEKEQELSKQIKDLNE 282

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1039770408  420 RLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 464
Cdd:pfam15905  283 KCKLLESEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQ 327
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 193-313 2.06e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.45  E-value: 2.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSS------------------- 253
Cdd:COG1579     18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYeeqlgnvrnnkeyealqke 97

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039770408  254 -EGIKKKLVEAE----ELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLE 313
Cdd:COG1579     98 iESLKRRISDLEdeilELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELE 162
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 492-611 2.11e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 41.97  E-value: 2.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  492 IQALTahrDEIQRKFDALRNSCT-VITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN--DEIVQLRSEVDHLRREI 568
Cdd:cd22656    119 IKALL---DDLLKEAKKYQDKAAkVVDKLTDFENQTEKDQTALETLEKALKDLLTDEGGAIarKEIKDLQKELEKLNEEY 195

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1039770408  569 TER---EMQLTSQKQAQLSApDLQTMEALKTTCTMLEEQVLDLEAL 611
Cdd:cd22656    196 AAKlkaKIDELKALIADDEA-KLAAALRLIADLTAADTDLDNLLAL 240
PRK12704 PRK12704
phosphodiesterase; Provisional
 657-793 2.11e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 2.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  657 ADQRITESRQVVELAVKEHKAEILALQQALKEqklKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 736
Cdd:PRK12704    62 AKEEIHKLRNEFEKELRERRNELQKLEKRLLQ---KEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIE 138

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039770408  737 KLQQQMDlqknHIFRLTQglQEAldRADLLKTERSDLEYQlenIQVLY--SHEKVKMEG 793
Cdd:PRK12704   139 EQLQELE----RISGLTA--EEA--KEILLEKVEEEARHE---AAVLIkeIEEEAKEEA 186
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 556-885 2.47e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  556 QLRSEVDHLRREItEREMQLTSQKQAQLSAPDLQ-TMEALKTTCTMLEEQVLDLEALNDELLEKERqweawrsVLGDEKS 634
Cdd:pfam17380  300 RLRQEKEEKAREV-ERRRKLEEAEKARQAEMDRQaAIYAEQERMAMERERELERIRQEERKRELER-------IRQEEIA 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  635 QFECRVRELQRMLDTEKQSRARADQRITESRQvVELAVKEHkaeilalQQALKEQKLKAESLSDKlndlekkhamlEMNA 714
Cdd:pfam17380  372 MEISRMRELERLQMERQQKNERVRQELEAARK-VKILEEER-------QRKIQQQKVEMEQIRAE-----------QEEA 432

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  715 RSLQ-QKLETERELK-QRLLEEQAKLQQQMDlqknhifRLTQglQEALDRADLLKTERSDLEYQL---ENIQVLYSHEKV 789
Cdd:pfam17380  433 RQREvRRLEEERAREmERVRLEEQERQQQVE-------RLRQ--QEEERKRKKLELEKEKRDRKRaeeQRRKILEKELEE 503

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  790 KMEGTISQQTKLiDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL----QYNELKLALEKEKARCaeleEALQKTRIEL 865
Cdd:pfam17380  504 RKQAMIEEERKR-KLLEKEMEERQKAIYEEERRREAEEERRKQQEMeerrRIQEQMRKATEERSRL----EAMEREREMM 578

                          330       340
                   ....*....|....*....|
gi 1039770408  866 RSAREEAAHRKATDHPHPST 885
Cdd:pfam17380  579 RQIVESEKARAEYEATTPIT 598
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 68-618 2.57e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.73  E-value: 2.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   68 EVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVsarrrsDLYESELRESRLAAEEFKRKANEC 147
Cdd:TIGR01612 1230 KIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEMETF------NISHDDDKDHHIISKKHDENISDI 1303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  148 QHKLMKVVshppRGDSGGTALDDLHKMQGHAGLTSAKDQGkpEVGEYskLEKI-NAEQQLKIQELQEKLEKAVKASTEAT 226
Cdd:TIGR01612 1304 REKSLKII----EDFSEESDINDIKKELQKNLLDAQKHNS--DINLY--LNEIaNIYNILKLNKIKKIIDEVKEYTKEIE 1375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  227 ELLQNIRQAKERAERELEKLhnREDSS-EGIKKKL---VEAEELEEKHREAQVSAQHL-------EVHLKQKEQHYE--- 292
Cdd:TIGR01612 1376 ENNKNIKDELDKSEKLIKKI--KDDINlEECKSKIestLDDKDIDECIKKIKELKNHIlseesniDTYFKNADENNEnvl 1453

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  293 ---EKIKVLDNQ------IKKDLADKESLENMMQRHE---------EEAHEKGKILSEQKAMINAMDSKIRSLEQRIVEL 354
Cdd:TIGR01612 1454 llfKNIEMADNKsqhilkIKKDNATNDHDFNINELKEhidkskgckDEADKNAKAIEKNKELFEQYKKDVTELLNKYSAL 1533

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  355 SEANKLAansslftqRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEqlEKISHQD---HSDKSrlleletrlrev 431
Cdd:TIGR01612 1534 AIKNKFA--------KTKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKK--EKFRIEDdaaKNDKS------------ 1591

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  432 sleheeqklelKRQLTELQLSLQERESQLTALQAARAALESQLRQAkteleettaeaeeeiqaltahrDEIQRKFDALR- 510
Cdd:TIGR01612 1592 -----------NKAAIDIQLSLENFENKFLKISDIKKKINDCLKET----------------------ESIEKKISSFSi 1638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  511 -NSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIterEMQLTsQKQAQLSAPDLQ 589
Cdd:TIGR01612 1639 dSQDTELKENGDNLNSLQEFLESLKDQKKNIEDKKKELDELDSEIEKIEIDVDQHKKNY---EIGII-EKIKEIAIANKE 1714

                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 1039770408  590 TMEALKTTCTMLEEQVL------DLEALN-DELLEK 618
Cdd:TIGR01612 1715 EIESIKELIEPTIENLIssfntnDLEGIDpNEKLEE 1750
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
437-737 2.58e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 41.82  E-value: 2.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  437 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettAEAEEEIQALTAHRDEIQRKFDALRnsctvi 516
Cdd:COG1340      1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELA-------EKRDELNAQVKELREEAQELREKRD------ 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  517 tDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIT--EREMQ---LTSQKQAQLsapdlqtM 591
Cdd:COG1340     68 -ELNEKVKELKEERDELNEKLNELREELDELRKELAELNKAGGSIDKLRKEIErlEWRQQtevLSPEEEKEL-------V 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  592 EALKTTCTMLEEqVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQrITESRqvvela 671
Cdd:COG1340    140 EKIKELEKELEK-AKKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADE-LRKEA------ 211

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039770408  672 vKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmnarslQQKLETERELKQRLLEEQAK 737
Cdd:COG1340    212 -DELHKEIVEAQEKADELHEEIIELQKELRELRKELKKLR------KKQRALKREKEKEELEEKAE 270
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 193-758 2.62e-03

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 42.43  E-value: 2.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  193 EYSKLEKINAEQQLKIQELQEKLEKAVKASTE--------ATELLQNIRQAKERAERELEKLHNREDSS----------- 253
Cdd:pfam07111   87 ETSLQQKMRLEAQAMELDALAVAEKAGQAEAEglraalagAEMVRKNLEEGSQRELEEIQRLHQEQLSSltqaheealss 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  254 -----EGIKKKLV--------EAEELEEKHREAQVsaqhLEVHLKQKEQHYEEKIKVLDNqIKKDLADKESLENMMQRHE 320
Cdd:pfam07111  167 ltskaEGLEKSLNsletkragEAKQLAEAQKEAEL----LRKQLSKTQEELEAQVTLVES-LRKYVGEQVPPEVHSQTWE 241

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  321 EEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslftqrnmkaQEEMISELRQQKFYLETQAGKleaqn 400
Cdd:pfam07111  242 LERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLAL--------------QEEELTRKIQPSDSLEPEFPK----- 302

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  401 rkleeqleKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQlslqereSQLTALQAARAALESQLrQAKTE 480
Cdd:pfam07111  303 --------KCRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAELQ-------EQVTSQSQEQAILQRAL-QDKAA 366

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  481 LEETTAEAEEEIQAltahrdEIQRKFDALRNSCTVITDLEEQL----NQLTEDNAELNNQNFYLSKQLDEASGANDEIVQ 556
Cdd:pfam07111  367 EVEVERMSAKGLQM------ELSRAQEARRRQQQQTASAEEQLkfvvNAMSSTQIWLETTMTRVEQAVARIPSLSNRLSY 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  557 LRSEVdHLRREITEREMQLTSQKQAQ----LSAPDLQTMEALKTTCTMLEEQVLDLE-ALNDELLEKE-----RQWEAWR 626
Cdd:pfam07111  441 AVRKV-HTIKGLMARKVALAQLRQEScpppPPAPPVDADLSLELEQLREERNRLDAElQLSAHLIQQEvgrarEQGEAER 519

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  627 SVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAES-----LSD--- 698
Cdd:pfam07111  520 QQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQEKVAEVETrlreqLSDtkr 599

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039770408  699 KLNDLEKKHAMLEMNARSLQQKLETERELKQ---RLLEEQAKLQQQmdlqknhifRLTQGLQE 758
Cdd:pfam07111  600 RLNEARREQAKAVVSLRQIQHRATQEKERNQelrRLQDEARKEEGQ---------RLARRVQE 653
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 492-695 2.65e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.12  E-value: 2.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  492 IQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNnqnfylsKQLDEAsgaNDEIVQLRSEVDHLRREITER 571
Cdd:COG3883     25 LSELQAELEAAQAELDALQAE---LEELNEEYNELQAELEALQ-------AEIDKL---QAEIAEAEAEIEERREELGER 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  572 --------------EMQLTSQKQA----------QLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRS 627
Cdd:COG3883     92 aralyrsggsvsylDVLLGSESFSdfldrlsalsKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770408  628 VLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAES 695
Cdd:COG3883    172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 195-478 2.67e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 42.52  E-value: 2.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  195 SKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAereLEKLHNREDSSEGIKKKLVEAEELEEKHREAQ 274
Cdd:PRK04778   112 SLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRELRKSL---LANRFSFGPALDELEKQLENLEEEFSQFVELT 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  275 VSAQHLEVH---LKQKE-----QHYEEKIKVLDNQIKKDLADK-ESLENMMQRHEEEAH--EKGKILSEqkamINAMDSK 343
Cdd:PRK04778   189 ESGDYVEAReilDQLEEelaalEQIMEEIPELLKELQTELPDQlQELKAGYRELVEEGYhlDHLDIEKE----IQDLKEQ 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  344 IRSLEQRIVEL-----SEANKLAANS-----SLFtQRNMKAQEEMISELRQQKFYLEtqagKLEAQNRKLEEQLEKISHQ 413
Cdd:PRK04778   265 IDENLALLEELdldeaEEKNEEIQERidqlyDIL-EREVKARKYVEKNSDTLPDFLE----HAKEQNKELKEEIDRVKQS 339

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770408  414 ---DHSDKSRLLELETRLREvsleheeqkleLKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 478
Cdd:PRK04778   340 ytlNESELESVRQLEKQLES-----------LEKQYDEITERIAEQEIAYSELQEELEEILKQLEEIE 396
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 5-476 3.51e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 42.34  E-value: 3.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408    5 EEAMMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDL------ATYITECSSLKRSLEQARMEVSQEDDKAL- 77
Cdd:TIGR00606  585 EINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLfdvcgsQDEESDLERLKEEIEKSSKQRAMLAGATAv 664

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   78 --QLLHDIREQSRKLQEIKEQEYQAQvEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFkrkanecqhklmkvv 155
Cdd:TIGR00606  665 ysQFITQLTDENQSCCPVCQRVFQTE-AELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEM--------------- 728

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  156 shpprgdsggtalddLHKMQGHAGLTSAKDQGKPEVGEysKLEKINAEQQLKIQEL--QEKLEKAVKASTEATE------ 227
Cdd:TIGR00606  729 ---------------LGLAPGRQSIIDLKEKEIPELRN--KLQKVNRDIQRLKNDIeeQETLLGTIMPEEESAKvcltdv 791

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  228 -LLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLEVHLK--QKEQHYEEKIKVLDNQIKK 304
Cdd:TIGR00606  792 tIMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKliQDQQEQIQHLKSKTNELKS 871

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  305 DLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSlfTQRNMKAQEE---MISE 381
Cdd:TIGR00606  872 EKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSK--ETSNKKAQDKvndIKEK 949

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  382 LRQQKFYLET-----QAGKlEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKleLKRQLTELQLSLQER 456
Cdd:TIGR00606  950 VKNIHGYMKDienkiQDGK-DDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQK--IQERWLQDNLTLRKR 1026

                          490       500
                   ....*....|....*....|
gi 1039770408  457 ESQLTALQAARAALESQLRQ 476
Cdd:TIGR00606 1027 ENELKEVEEELKQHLKEMGQ 1046
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
58-326 3.60e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 41.43  E-value: 3.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   58 LKRSLEQARMEVSQEDDKalqlLHDIREQSRKLQEiKEQEYQAQVEEMRLMMNQLEEdlvsarRRSDLYEsELRESRLAA 137
Cdd:COG1340     13 LEEKIEELREEIEELKEK----RDELNEELKELAE-KRDELNAQVKELREEAQELRE------KRDELNE-KVKELKEER 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  138 EEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHKmqghagltsakdqgkpevgEYSKLEK--------INAEQQL--K 207
Cdd:COG1340     81 DELNEKLNELREELDELRKELAELNKAGGSIDKLRK-------------------EIERLEWrqqtevlsPEEEKELveK 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  208 IQELQEKLE---KAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV-----------EAEELEEKHREA 273
Cdd:COG1340    142 IKELEKELEkakKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIelykeadelrkEADELHKEIVEA 221

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039770408  274 QVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLE-NMMQRHEEEAHEK 326
Cdd:COG1340    222 QEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEkEELEEKAEEIFEK 275
C1_PKD_rpt2 cd20796
second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D ...
 941-990 3.74e-03

second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D (PKD); PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs contain N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410346  Cd Length: 54  Bit Score: 36.88  E-value: 3.74e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039770408  941 PHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 990
Cdd:cd20796      1 PHTFVVHTYTKPTVCQHCKKLLKgLFRQGLQCKDCKFNCHKKCAEKVPKDC 51
mukB PRK04863
chromosome partition protein MukB;
318-740 3.84e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.25  E-value: 3.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  318 RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQA 393
Cdd:PRK04863   276 RHANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMArELAELNEAESDLEQDYQAASDHlnlVQTALRQQE-KIERYQ 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  394 GKLEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVslehEEQKLELKRQLTELQLSLQeresqltaLQAARAaleSQ 473
Cdd:PRK04863   355 ADLEELEERLEEQNEVVEEAD----EQQEENEARAEAA----EEEVDELKSQLADYQQALD--------VQQTRA---IQ 415

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  474 LRQAKteleettaeaeeeiQALtahrDEIQR--KFDALrnsctVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN 551
Cdd:PRK04863   416 YQQAV--------------QAL----ERAKQlcGLPDL-----TADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAH 472

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  552 DEIVQ----LRSEVDHLRRE-----ITEREMQLTSQKQAQLSAPDLQTmeALKTTCTMLEEQVlDLEALNDELLEKERQW 622
Cdd:PRK04863   473 SQFEQayqlVRKIAGEVSRSeawdvARELLRRLREQRHLAEQLQQLRM--RLSELEQRLRQQQ-RAERLLAEFCKRLGKN 549

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  623 EAWRSVLGDEKSQFECRVRELqrmldteKQSRARADQRITESRQVVElavkEHKAEIlalqQALKEQKLKAESLSDKLND 702
Cdd:PRK04863   550 LDDEDELEQLQEELEARLESL-------SESVSEARERRMALRQQLE----QLQARI----QRLAARAPAWLAAQDALAR 614

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039770408  703 L-EKKHAMLEMNAR---SLQQKLETEREL----------KQRLLEEQAKLQQ 740
Cdd:PRK04863   615 LrEQSGEEFEDSQDvteYMQQLLERERELtverdelaarKQALDEEIERLSQ 666
PRK12704 PRK12704
phosphodiesterase; Provisional
 673-800 4.11e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 4.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  673 KEHKAEILAlQQALKEQKLKAESLsdklndleKKHAMLEMNARSLQQKLETERELKQRLLEEQA---KLQQQMDLQKNHI 749
Cdd:PRK12704    32 KIKEAEEEA-KRILEEAKKEAEAI--------KKEALLEAKEEIHKLRNEFEKELRERRNELQKlekRLLQKEENLDRKL 102

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039770408  750 FRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEgTISQQTK 800
Cdd:PRK12704   103 ELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELE-RISGLTA 152
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 206-358 4.14e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.96  E-value: 4.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  206 LKIQ-ELQEKLEKAVKASTEATELL--------QNIRQAKERAERElEKLHNREDSSEGIKK-----KLVE-----AEEL 266
Cdd:TIGR01612  561 HEIKkELEEENEDSIHLEKEIKDLFdkyleiddEIIYINKLKLELK-EKIKNISDKNEYIKKaidlkKIIEnnnayIDEL 639

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  267 eekhreAQVSAQHLEVHLKQKEQHYEeKIKVLDNQIKKDLADK--ESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 344
Cdd:TIGR01612  640 ------AKISPYQVPEHLKNKDKIYS-TIKSELSKIYEDDIDAlyNELSSIVKENAIDNTEDKAKLDDLKSKIDKEYDKI 712

                          170
                   ....*....|....
gi 1039770408  345 RSLEQRIVELSEAN 358
Cdd:TIGR01612  713 QNMETATVELHLSN 726
C1_TNS2 cd20887
protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; ...
 941-993 4.27e-03

protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; Tensin-2 (TNS2), also called C1 domain-containing phosphatase and tensin (C1-TEN), or tensin-like C1 domain-containing phosphatase (TENC1), is an essential component for the maintenance of glomerular basement membrane (GBM) structures. It regulates cell motility and proliferation. It may have phosphatase activity. TNS2 reduces AKT1 phosphorylation, lowers AKT1 kinase activity, and interferes with AKT1 signaling. It contains an N-terminal region with a zinc finger (C1 domain), a protein tyrosine phosphatase (PTP)-like domain and a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410437  Cd Length: 53  Bit Score: 37.07  E-value: 4.27e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039770408  941 PHRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKCSTCLPATCGLP 993
Cdd:cd20887      2 PHSFKEKTFKKKRACAVCREPV--GGQGLVCRVCKVASHKKCEAKVTSACQPP 52
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 368-575 4.41e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 40.27  E-value: 4.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  368 TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL---EKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR 444
Cdd:pfam15619    2 TQRVLSARLHKIKELQNELAELQSKLEELRKENRLLKRLQkrqEKALGKYEGTESELPQLIARHNEEVRVLRERLRRLQE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  445 QLTELQLSLQERESQLTALQAARAALEsQLRQAKTEleettaeaeeeiqaltAHRDEIQRKFDALRNsctvITDLEEQLN 524
Cdd:pfam15619   82 KERDLERKLKEKEAELLRLRDQLKRLE-KLSEDKNL----------------AEREELQKKLEQLEA----KLEDKDEKI 140

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039770408  525 QLTEDNAELNNQNF--YLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL 575
Cdd:pfam15619  141 QDLERKLELENKSFrrQLAAEKKKHKEAQEEVKILQEEIERLQQKLKEKEREL 193
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 78-278 4.45e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 4.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   78 QLLHDIREQSRKLQEIKEQE--YQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVV 155
Cdd:COG4942     31 QLQQEIAELEKELAALKKEEkaLLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELL 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  156 ---------SHPPRGDSGGTALDDLHKMQGHAGLTSA-KDQGKpevgeysKLEKINAEQQLKIQELQEKLEKAVKASTEA 225
Cdd:COG4942    111 ralyrlgrqPPLALLLSPEDFLDAVRRLQYLKYLAPArREQAE-------ELRADLAELAALRAELEAERAELEALLAEL 183

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039770408  226 TELLQNIRQAKERAERELEKLHNREDSSEG-IKKKLVEAEELEEKHREAQVSAQ 278
Cdd:COG4942    184 EEERAALEALKAERQKLLARLEKELAELAAeLAELQQEAEELEALIARLEAEAA 237
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 444-875 5.04e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.58  E-value: 5.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  444 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD----- 518
Cdd:PRK10929     2 RLIITFLMAWLLSWGAYAATAPDEKQITQELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQYQQVIDNfpkls 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  519 --LEEQLNQLTED---------NAELNNQNFYLSKQLDEASGandeivQLRSEVDHLrREITEREMQLTSQKQA---QLS 584
Cdd:PRK10929    82 aeLRQQLNNERDEprsvppnmsTDALEQEILQVSSQLLEKSR------QAQQEQDRA-REISDSLSQLPQQQTEarrQLN 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  585 APDlQTMEALKTTCTMLEE-QVLDLEAlndellekerqweawrsvlgdEKSQFECRVRELQrmldtekQSRARADQRITE 663
Cdd:PRK10929   155 EIE-RRLQTLGTPNTPLAQaQLTALQA---------------------ESAALKALVDELE-------LAQLSANNRQEL 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  664 SRQVVELAVKEHkAEILALQQALKEQklkaeslsdkLNDLEKKHA--------MLEMNA----RSLQQKLETERELKQrL 731
Cdd:PRK10929   206 ARLRSELAKKRS-QQLDAYLQALRNQ----------LNSQRQREAeralesteLLAEQSgdlpKSIVAQFKINRELSQ-A 273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  732 LEEQAklqQQMDL----QK---NHIFRLTQGLQ----------------EALdRADLLKTERSDLEYQLENIQVLYSHEK 788
Cdd:PRK10929   274 LNQQA---QRMDLiasqQRqaaSQTLQVRQALNtlreqsqwlgvsnalgEAL-RAQVARLPEMPKPQQLDTEMAQLRVQR 349

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  789 VKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFsrrkeDPALPTQVPL------QYNELKLALEKEKARCAELEEALQKTR 862
Cdd:PRK10929   350 LRYEDLLNKQPQLRQIRQADGQPLTAEQNRIL-----DAQLRTQRELlnsllsGGDTLILELTKLKVANSQLEDALKEVN 424

                          490
                   ....*....|...
gi 1039770408  863 ielrsareEAAHR 875
Cdd:PRK10929   425 --------EATHR 429
C1_Munc13 cd20807
protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene ...
 942-990 6.18e-03

protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene family encodes a family of neuron-specific, synaptic molecules that bind to syntaxin, an essential mediator of neurotransmitter release. Munc13-1 is a component of presynaptic active zones in which it acts as an essential synaptic vesicle priming protein. Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410357  Cd Length: 53  Bit Score: 36.30  E-value: 6.18e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039770408  942 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 990
Cdd:cd20807      1 HNFEVWTATTPTYCYECEGLLwGIARQGVRCTECGVKCHEKCKDLLNADC 50
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
10-246 7.38e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.05  E-value: 7.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   10 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQ---------DLATYITECSS-----------------LKRSLE 63
Cdd:COG4913    616 EAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeiDVASAEREIAEleaelerldassddlaaLEEQLE 695

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   64 QARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRS---DLYESELRE---SRL 135
Cdd:COG4913    696 ELEAELEELEEELDELKGEIGRLEKELEQAEEEldELQDRLEAAEDLARLELRALLEERFAAalgDAVERELREnleERI 775

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  136 AAEefKRKANECQHKLMKVVSH-----PPRGDSGGTALDDLHKMQGHagltsakdqgkpevgeYSKLEKINAEqqlkiqE 210
Cdd:COG4913    776 DAL--RARLNRAEEELERAMRAfnrewPAETADLDADLESLPEYLAL----------------LDRLEEDGLP------E 831

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1039770408  211 LQEKLEKAVKASTEA--TELLQNIRQAKERAERELEKL 246
Cdd:COG4913    832 YEERFKELLNENSIEfvADLLSKLRRAIREIKERIDPL 869
PLN02939 PLN02939
transferase, transferring glycosyl groups
 244-465 7.45e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 41.04  E-value: 7.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  244 EKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKEslenmmqrheeea 323
Cdd:PLN02939    94 DDDHNRASMQRDEAIAAIDNEQQTNSKDGEQLSDFQLE-DLVGMIQNAEKNILLLNQARLQALEDLE------------- 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  324 hekgKILSEQKAMinamDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQkfyLETQAGKLEAqnrkL 403
Cdd:PLN02939   160 ----KILTEKEAL----QGKINILEMRLSETDARIKLAAQEKIHVEILEEQLEKLRNELLIR---GATEGLCVHS----L 224

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039770408  404 EEQLEKISHQDHSDKSRLLELETRLREVSlEHEEQKLELKRQLTELQLSLQERESQLTALQA 465
Cdd:PLN02939   225 SKELDVLKEENMLLKDDIQFLKAELIEVA-ETEERVFKLEKERSLLDASLRELESKFIVAQE 285
Filament pfam00038
Intermediate filament protein;
417-743 8.02e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 40.29  E-value: 8.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  417 DKSRLLELETRLREVSL-EHEEQKLELKRQLTEL-QLSLQERESQLTALQAARAALESQLRQAkteleettaeaeeeiqa 494
Cdd:pfam00038   18 DKVRFLEQQNKLLETKIsELRQKKGAEPSRLYSLyEKEIEDLRRQLDTLTVERARLQLELDNL----------------- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  495 ltahRDEIQRkfdaLRNSctvitdLEEQLNQLTEDNAELNNqnfyLSKQLDEASGANdeiVQLRSEVDHLRREIT----- 569
Cdd:pfam00038   81 ----RLAAED----FRQK------YEDELNLRTSAENDLVG----LRKDLDEATLAR---VDLEAKIESLKEELAflkkn 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  570 -EREMqltSQKQAQLSAPDLQtMEALKTTCTMLEEQVLDLEALNDELLEKERQweawrsvlgDEKSQFECRVRELQRMLD 648
Cdd:pfam00038  140 hEEEV---RELQAQVSDTQVN-VEMDAARKLDLTSALAEIRAQYEEIAAKNRE---------EAEEWYQSKLEELQQAAA 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  649 TEKQSRARADQRITESRQVVElavkehkaeilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETE-REL 727
Cdd:pfam00038  207 RNGDALRSAKEEITELRRTIQ-----------SLEIELQSLKKQKASLERQLAETEERYELQLADYQELISELEAElQET 275

                          330
                   ....*....|....*.
gi 1039770408  728 KQRLLEEQAKLQQQMD 743
Cdd:pfam00038  276 RQEMARQLREYQELLN 291
GBP_C pfam02841
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ...
 657-774 8.26e-03

Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.


Pssm-ID: 460721 [Multi-domain]  Cd Length: 297  Bit Score: 40.35  E-value: 8.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  657 ADQRITESrqvvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHamlEMNARSLQQKLETERELKQRllEEQA 736
Cdd:pfam02841  195 TDQALTAK----EKAIEAERAKAEAAEAEQELLREKQKEEEQMMEAQERSY---QEHVKQLIEKMEAEREQLLA--EQER 265

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1039770408  737 KLQQQMDLQKNhifRLTQGLQEaldRADLLKTERSDLE 774
Cdd:pfam02841  266 MLEHKLQEQEE---LLKEGFKT---EAESLQKEIQDLK 297
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 257-780 8.34e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 40.96  E-value: 8.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  257 KKKLVEAEELEEKHREAQVSAQHLEVHLKQK---------EQHYE-------EKIKVLDNQIKKDLADKESLENMMQR-- 318
Cdd:pfam10174  174 KKSGEEDWERTRRIAEAEMQLGHLEVLLDQKekenihlreELHRRnqlqpdpAKTKALQTVIEMKDTKISSLERNIRDle 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  319 ------------HEEEAHEKGKILSEQKAMINAMDSKIRSLEQrivELS--EANKLAANSSLFTQRNM------------ 372
Cdd:pfam10174  254 devqmlktngllHTEDREEEIKQMEVYKSHSKFMKNKIDQLKQ---ELSkkESELLALQTKLETLTNQnsdckqhievlk 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  373 -----KAQEEMI--SELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDH--SDKSRLLELETR-----------LREVS 432
Cdd:pfam10174  331 esltaKEQRAAIlqTEVDALRLRLEEKESFLNKKTKQLQDLTEEKSTLAGeiRDLKDMLDVKERkinvlqkkienLQEQL 410

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  433 LEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALEsqlrqakteleettaeaeEEIQALTAHRD-EIQRKFDALRN 511
Cdd:pfam10174  411 RDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEALSEKE------------------RIIERLKEQRErEDRERLEELES 472

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  512 SCTVITDLEEQLNQLtedNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREItEREMQLTSQKQAQLsaPDLQTM 591
Cdd:pfam10174  473 LKKENKDLKEKVSAL---QPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAV-EQKKEECSKLENQL--KKAHNA 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  592 EALKTTCTMLEEQVldlealndELLEKERQWEAWRSvlgdEKSQFEC-RVRELQRMLDTEKQSRaraDQRITEsrqvvel 670
Cdd:pfam10174  547 EEAVRTNPEINDRI--------RLLEQEVARYKEES----GKAQAEVeRLLGILREVENEKNDK---DKKIAE------- 604

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  671 avkehkAEILALQQaLKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQ--RLLEEQAKLQQQMDLQKNH 748
Cdd:pfam10174  605 ------LESLTLRQ-MKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQleELMGALEKTRQELDATKAR 677

                          570       580       590
                   ....*....|....*....|....*....|..
gi 1039770408  749 IFRLTQGLQEaldRADLLKTERSDLEYQLENI 780
Cdd:pfam10174  678 LSSTQQSLAE---KDGHLTNLRAERRKQLEEI 706
fliH PRK06669
flagellar assembly protein H; Validated
 194-355 9.55e-03

flagellar assembly protein H; Validated


Pssm-ID: 235850 [Multi-domain]  Cd Length: 281  Bit Score: 40.00  E-value: 9.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  194 YSKLEKINAEQ--QLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLH--NREDSSEGIKKKLVEA-EELEE 268
Cdd:PRK06669     6 FKRSNVINKEKlkTHEIQKYRFKVLSIKEKERLREEEEEQVEQLREEANDEAKEIIeeAEEDAFEIVEAAEEEAkEELLK 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  269 KHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADK---ESLENMMQRHEEEAHEKGKILSEqkaMINAMDSKIR 345
Cdd:PRK06669    86 KTDEASSIIEKLQMQIEREQEEWEEELERLIEEAKAEGYEEgyeKGREEGLEEVRELIEQLNKIIEK---LIKKREEILE 162

                          170
                   ....*....|
gi 1039770408  346 SLEQRIVELS 355
Cdd:PRK06669   163 SSEEEIVELA 172
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 73-278 9.69e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.20  E-value: 9.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408   73 DDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELresrlaaEEFKRKANECQHK 150
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAEldALQAELEELNEEYNELQAELEALQAEIDKLQAEI-------AEAEAEIEERREE 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  151 LMKVVSHPPRGDSGGTAL----------DDLHKMQghaGLTSAKDQGKPEVGEYSKLEKINAEQQlkiQELQEKLEKAVK 220
Cdd:COG3883     88 LGERARALYRSGGSVSYLdvllgsesfsDFLDRLS---ALSKIADADADLLEELKADKAELEAKK---AELEAKLAELEA 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039770408  221 ASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEELEEKHREAQVSAQ 278
Cdd:COG3883    162 LKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAA 219
46 PHA02562
endonuclease subunit; Provisional
 398-706 9.85e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 40.38  E-value: 9.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  398 AQNRKLEEQLEKISHQDHSDKSrlleLETRLREvsLEHEEQKLELKRQLTELQLSLQER-ESQLTALQAARaalesqlrq 476
Cdd:PHA02562   150 PARRKLVEDLLDISVLSEMDKL----NKDKIRE--LNQQIQTLDMKIDHIQQQIKTYNKnIEEQRKKNGEN--------- 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  477 akteleettaeaeeeiqaltahRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNnqnfylsKQLDEASGA----ND 552
Cdd:PHA02562   215 ----------------------IARKQNKYDELVEE---AKTIKAEIEELTDELLNLV-------MDIEDPSAAlnklNT 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  553 EIVQLRSEVDHLRREITERE--------MQLTSQKQAQLSapDLQT-MEALKTTCTMLEEQVLDLEALNDELLEKERqwe 623
Cdd:PHA02562   263 AAAKIKSKIEQFQKVIKMYEkggvcptcTQQISEGPDRIT--KIKDkLKELQHSLEKLDTAIDELEEIMDEFNEQSK--- 337

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039770408  624 awrsvlgdeksqfecRVRELQRMLDTEKQSRARADQRITESRQVVELAVKE---HKAEILALQQALKEqklkaesLSDKL 700
Cdd:PHA02562   338 ---------------KLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEfvdNAEELAKLQDELDK-------IVKTK 395


                   ....*.
gi 1039770408  701 NDLEKK 706
Cdd:PHA02562   396 SELVKE 401
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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