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Conserved domains on  [gi|767990222|ref|XP_011521512|]
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sphingomyelin phosphodiesterase 3 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EEP super family cl00490
Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes ...
 338-441 3.70e-34

Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes the catalytic domain (exonuclease/endonuclease/phosphatase or EEP domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds; their substrates range from nucleic acids to phospholipids and perhaps proteins.


The actual alignment was detected with superfamily member cd09078:

Pssm-ID: 469791 [Multi-domain]  Cd Length: 280  Bit Score: 129.38  E-value: 3.70e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990222 338 RRHPDEAFDHEVSAFFPANL--DFLCLQEVFDKRAATKLKEQLHGYFeYILYDVGVYGCQGCcSFKCLNSGLLFASRYPI 415
Cdd:cd09078   16 YNNGDDGQDERLDLIPKALLqyDVVVLQEVFDARARKRLLNGLKKEY-PYQTDVVGRSPSGW-SSKLVDGGVVILSRYPI 93

                         90       100
                 ....*....|....*....|....*.
gi 767990222 416 MDVAYHCYPNKCNDDALASKGALFLK 441
Cdd:cd09078   94 VEKDQYIFPNGCGADCLAAKGVLYAK 119
dermokine super family cl42387
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 197-321 1.19e-03

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


The actual alignment was detected with superfamily member cd21118:

Pssm-ID: 455732 [Multi-domain]  Cd Length: 495  Bit Score: 41.14  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990222 197 ARAVPGSIKRTASVEYKGDGGRHP-GDEAANGPASGDPVDSSSPEDACIVRIGGEEGGRPpeaddpvpGGQARNGAGGGP 275
Cdd:cd21118  184 AVAQPGYGTVRGNNQNSGCTNPPPsGSHESFSNSGGSSSSGSSGSQGSHGSNGQGSSGSS--------GGQGNGGNNGSS 255

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767990222 276 RGQT-PNHNQQDGDSGSLGSPSASRESLVKGRAGPDTSASGEPGANS 321
Cdd:cd21118  256 SSNSgNSGGSNGGSSGNSGSGSGGSSSGGSNGWGGSSSSGGSGGSGG 302
 
Name Accession Description Interval E-value
nSMase cd09078
Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological ...
 338-441 3.70e-34

Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Sphingomyelinases (SMase) are phosphodiesterases that catalyze the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Eukaryotic SMases have been classified according to their pH optima and are known as acid SMase, alkaline SMase, and neutral SMase (nSMase). Eukaryotic proteins in this family are nSMases, and are activated by a variety of stress-inducing agents such as cytokines or UV radiation. Ceramides and other metabolic derivatives, including sphingosine, are lipid "second messenger" molecules that participate in the regulation of stress-induced cellular responses, including cell death, adhesion, differentiation, and proliferation. Bacterial neutral SMases, which also belong to this domain family, are secreted proteins that act as membrane-damaging virulence factors. They promote colonization of the host tissue. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.


Pssm-ID: 197312 [Multi-domain]  Cd Length: 280  Bit Score: 129.38  E-value: 3.70e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990222 338 RRHPDEAFDHEVSAFFPANL--DFLCLQEVFDKRAATKLKEQLHGYFeYILYDVGVYGCQGCcSFKCLNSGLLFASRYPI 415
Cdd:cd09078   16 YNNGDDGQDERLDLIPKALLqyDVVVLQEVFDARARKRLLNGLKKEY-PYQTDVVGRSPSGW-SSKLVDGGVVILSRYPI 93

                         90       100
                 ....*....|....*....|....*.
gi 767990222 416 MDVAYHCYPNKCNDDALASKGALFLK 441
Cdd:cd09078   94 VEKDQYIFPNGCGADCLAAKGVLYAK 119
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 197-321 1.19e-03

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 41.14  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990222 197 ARAVPGSIKRTASVEYKGDGGRHP-GDEAANGPASGDPVDSSSPEDACIVRIGGEEGGRPpeaddpvpGGQARNGAGGGP 275
Cdd:cd21118  184 AVAQPGYGTVRGNNQNSGCTNPPPsGSHESFSNSGGSSSSGSSGSQGSHGSNGQGSSGSS--------GGQGNGGNNGSS 255

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767990222 276 RGQT-PNHNQQDGDSGSLGSPSASRESLVKGRAGPDTSASGEPGANS 321
Cdd:cd21118  256 SSNSgNSGGSNGGSSGNSGSGSGGSSSGGSNGWGGSSSSGGSGGSGG 302
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 171-321 1.79e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990222  171 IDSPTNTSISAASFSSLVSPQGGDGVARA-VPGSIKRTASVEYKGDGGRHPGDeaangPASGDPVDSSSPEDACIVRIGG 249
Cdd:PHA03307  178 SPEETARAPSSPPAEPPPSTPPAAASPRPpRRSSPISASASSPAPAPGRSAAD-----DAGASSSDSSSSESSGCGWGPE 252

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767990222  250 EEGGRPPEADDPVPGGQARNGAGGGPRGQTPNHNQQDGDSGSLGSPSASRESLVKGRAGPDTSASGEPGANS 321
Cdd:PHA03307  253 NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRES 324
 
Name Accession Description Interval E-value
nSMase cd09078
Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological ...
 338-441 3.70e-34

Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Sphingomyelinases (SMase) are phosphodiesterases that catalyze the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Eukaryotic SMases have been classified according to their pH optima and are known as acid SMase, alkaline SMase, and neutral SMase (nSMase). Eukaryotic proteins in this family are nSMases, and are activated by a variety of stress-inducing agents such as cytokines or UV radiation. Ceramides and other metabolic derivatives, including sphingosine, are lipid "second messenger" molecules that participate in the regulation of stress-induced cellular responses, including cell death, adhesion, differentiation, and proliferation. Bacterial neutral SMases, which also belong to this domain family, are secreted proteins that act as membrane-damaging virulence factors. They promote colonization of the host tissue. This family belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.


Pssm-ID: 197312 [Multi-domain]  Cd Length: 280  Bit Score: 129.38  E-value: 3.70e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990222 338 RRHPDEAFDHEVSAFFPANL--DFLCLQEVFDKRAATKLKEQLHGYFeYILYDVGVYGCQGCcSFKCLNSGLLFASRYPI 415
Cdd:cd09078   16 YNNGDDGQDERLDLIPKALLqyDVVVLQEVFDARARKRLLNGLKKEY-PYQTDVVGRSPSGW-SSKLVDGGVVILSRYPI 93

                         90       100
                 ....*....|....*....|....*.
gi 767990222 416 MDVAYHCYPNKCNDDALASKGALFLK 441
Cdd:cd09078   94 VEKDQYIFPNGCGADCLAAKGVLYAK 119
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 197-321 1.19e-03

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 41.14  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990222 197 ARAVPGSIKRTASVEYKGDGGRHP-GDEAANGPASGDPVDSSSPEDACIVRIGGEEGGRPpeaddpvpGGQARNGAGGGP 275
Cdd:cd21118  184 AVAQPGYGTVRGNNQNSGCTNPPPsGSHESFSNSGGSSSSGSSGSQGSHGSNGQGSSGSS--------GGQGNGGNNGSS 255

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767990222 276 RGQT-PNHNQQDGDSGSLGSPSASRESLVKGRAGPDTSASGEPGANS 321
Cdd:cd21118  256 SSNSgNSGGSNGGSSGNSGSGSGGSSSGGSNGWGGSSSSGGSGGSGG 302
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 171-321 1.79e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767990222  171 IDSPTNTSISAASFSSLVSPQGGDGVARA-VPGSIKRTASVEYKGDGGRHPGDeaangPASGDPVDSSSPEDACIVRIGG 249
Cdd:PHA03307  178 SPEETARAPSSPPAEPPPSTPPAAASPRPpRRSSPISASASSPAPAPGRSAAD-----DAGASSSDSSSSESSGCGWGPE 252

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767990222  250 EEGGRPPEADDPVPGGQARNGAGGGPRGQTPNHNQQDGDSGSLGSPSASRESLVKGRAGPDTSASGEPGANS 321
Cdd:PHA03307  253 NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRES 324
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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