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Conserved domains on  [gi|754404605|ref|XP_011272531|]
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uncharacterized protein BN7_5195 [Wickerhamomyces ciferrii]

Protein Classification

PXA domain-containing protein( domain architecture ID 10490349)

PXA domain-containing protein similar to Homo sapiens sorting nexin-25 that negatively regulates TGF-beta signaling by enhancing the receptor degradation through lysosome pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PXA pfam02194
PXA domain; This domain is associated with PX domains pfam00787.
 76-250 1.07e-36

PXA domain; This domain is associated with PX domains pfam00787.


:

Pssm-ID: 460484  Cd Length: 181  Bit Score: 132.74  E-value: 1.07e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754404605   76 SSKLDIQLYCFLGLLIKNFINKWYYKLSDSPDFINELIQLISKITKDLEKRLQDVNFGEMILDDFFIILNNHLSLYKYIQ 155
Cdd:pfam02194   1 SPEVDAALDELIDLIIRDFVQSWYSKISSDPEFPNEVRQTLRHALRELSQRLRKVDLASLLLSRLLPLLTSHLEDYRKAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754404605  156 KNQDSMFLPIEPGDFHHGFDILDTHPGLNP------QDPDSESNYLRILSKNILRHLLPPEEQKSELVMEFMKSLISDLI 229
Cdd:pfam02194  81 EAVRGKKLNELDLALASKYLALKPHPALSPvllsssQSREAEQKYLRLLVDGLLPLLLPPEDLESRPVRVLVREILACLV 160

                         170       180
                  ....*....|....*....|.
gi 754404605  230 LRIILEKLTKPYQIMEIISII 250
Cdd:pfam02194 161 LLPVINKLSDPDFINELIVKL 181
 
Name Accession Description Interval E-value
PXA pfam02194
PXA domain; This domain is associated with PX domains pfam00787.
 76-250 1.07e-36

PXA domain; This domain is associated with PX domains pfam00787.


Pssm-ID: 460484  Cd Length: 181  Bit Score: 132.74  E-value: 1.07e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754404605   76 SSKLDIQLYCFLGLLIKNFINKWYYKLSDSPDFINELIQLISKITKDLEKRLQDVNFGEMILDDFFIILNNHLSLYKYIQ 155
Cdd:pfam02194   1 SPEVDAALDELIDLIIRDFVQSWYSKISSDPEFPNEVRQTLRHALRELSQRLRKVDLASLLLSRLLPLLTSHLEDYRKAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754404605  156 KNQDSMFLPIEPGDFHHGFDILDTHPGLNP------QDPDSESNYLRILSKNILRHLLPPEEQKSELVMEFMKSLISDLI 229
Cdd:pfam02194  81 EAVRGKKLNELDLALASKYLALKPHPALSPvllsssQSREAEQKYLRLLVDGLLPLLLPPEDLESRPVRVLVREILACLV 160

                         170       180
                  ....*....|....*....|.
gi 754404605  230 LRIILEKLTKPYQIMEIISII 250
Cdd:pfam02194 161 LLPVINKLSDPDFINELIVKL 181
PXA smart00313
Domain associated with PX domains; unpubl. observations
 78-240 1.24e-10

Domain associated with PX domains; unpubl. observations


Pssm-ID: 214611  Cd Length: 176  Bit Score: 60.12  E-value: 1.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754404605    78 KLDIQLYCFLGLLIKNFINKWYYKLSDSPDFINELIQLISKITKDLEKRLQDVNFGEMIlddFFIILNNHLSLYKYIQKN 157
Cdd:smart00313   3 QLEEPLQLLISKIIRDYVQGWYKGVSEDPSFLREIEQTLEYILRQLYRRLSRQDSAHLI---LYEILKNLISTITNALEA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754404605   158 QDSMFLPIEPgdfHHGFD--ILDTHPGLNPQDPDSESNYLRILSKNILRHLLPPEEQKSELVMEFMKSLISDLILRIILE 235
Cdd:smart00313  80 VLRFASPQIP---STEIDlqYAETAIHKALSSPSNELTYRRQLVEMLLKFLLPEDSLCSRLHRCLLREVLAMQVILPLIT 156


                   ....*
gi 754404605   236 KLTKP 240
Cdd:smart00313 157 HLSDP 161
 
Name Accession Description Interval E-value
PXA pfam02194
PXA domain; This domain is associated with PX domains pfam00787.
 76-250 1.07e-36

PXA domain; This domain is associated with PX domains pfam00787.


Pssm-ID: 460484  Cd Length: 181  Bit Score: 132.74  E-value: 1.07e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754404605   76 SSKLDIQLYCFLGLLIKNFINKWYYKLSDSPDFINELIQLISKITKDLEKRLQDVNFGEMILDDFFIILNNHLSLYKYIQ 155
Cdd:pfam02194   1 SPEVDAALDELIDLIIRDFVQSWYSKISSDPEFPNEVRQTLRHALRELSQRLRKVDLASLLLSRLLPLLTSHLEDYRKAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754404605  156 KNQDSMFLPIEPGDFHHGFDILDTHPGLNP------QDPDSESNYLRILSKNILRHLLPPEEQKSELVMEFMKSLISDLI 229
Cdd:pfam02194  81 EAVRGKKLNELDLALASKYLALKPHPALSPvllsssQSREAEQKYLRLLVDGLLPLLLPPEDLESRPVRVLVREILACLV 160

                         170       180
                  ....*....|....*....|.
gi 754404605  230 LRIILEKLTKPYQIMEIISII 250
Cdd:pfam02194 161 LLPVINKLSDPDFINELIVKL 181
PXA smart00313
Domain associated with PX domains; unpubl. observations
 78-240 1.24e-10

Domain associated with PX domains; unpubl. observations


Pssm-ID: 214611  Cd Length: 176  Bit Score: 60.12  E-value: 1.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754404605    78 KLDIQLYCFLGLLIKNFINKWYYKLSDSPDFINELIQLISKITKDLEKRLQDVNFGEMIlddFFIILNNHLSLYKYIQKN 157
Cdd:smart00313   3 QLEEPLQLLISKIIRDYVQGWYKGVSEDPSFLREIEQTLEYILRQLYRRLSRQDSAHLI---LYEILKNLISTITNALEA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754404605   158 QDSMFLPIEPgdfHHGFD--ILDTHPGLNPQDPDSESNYLRILSKNILRHLLPPEEQKSELVMEFMKSLISDLILRIILE 235
Cdd:smart00313  80 VLRFASPQIP---STEIDlqYAETAIHKALSSPSNELTYRRQLVEMLLKFLLPEDSLCSRLHRCLLREVLAMQVILPLIT 156


                   ....*
gi 754404605   236 KLTKP 240
Cdd:smart00313 157 HLSDP 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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