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Conserved domains on  [gi|755519665|ref|XP_011248886|]
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zinc finger protein 260 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
22-401 1.40e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665  22 VYECNECKETFSLEQNFVEHKKTHSGEKSPECTGCGEESSQASSLTLHLRSRPRRESYKcGECGKAFSQRGNFLSHQK-- 99
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPS-DLNSKSLPLSNSKASSSSls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 100 ------------QHTEERPSESKKTPVPM--TTTVRNQRNTGNKPYACK---------ECGKAFNGKSYLKE-----HEK 151
Cdd:COG5048  112 ssssnsndnnllSSHSLPPSSRDPQLPDLlsISNLRNNPLPGNNSSSVNtpqsnslhpPLPANSLSKDPSSNlslliSSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 152 IHTGEKPFECSQCGRAFSQKQYLIKHQNIHSGKKPFKCNECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQKSSLI 231
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 232 RHQRSHTGE-------KPYTCKECGKAFSGKSNLTEH--EKIHIGE--KPYKCNE--CGTIFRQKQYLIKHHNIHTGEKP 298
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 299 YEC-------------NKCGKAFSRITSLIVHVRIHTGDKPYECKICGKAFCQSSSLTVHMRSHTGEKPygCNECGKAFS 365
Cdd:COG5048  352 AKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCK--NPPCSKSFN 429

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 755519665 366 QFSTLALHMRIHTGEKPYQCSECGKAFSQK--SHHIRH 401
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLdlSNHGKD 467
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
22-401 1.40e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665  22 VYECNECKETFSLEQNFVEHKKTHSGEKSPECTGCGEESSQASSLTLHLRSRPRRESYKcGECGKAFSQRGNFLSHQK-- 99
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPS-DLNSKSLPLSNSKASSSSls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 100 ------------QHTEERPSESKKTPVPM--TTTVRNQRNTGNKPYACK---------ECGKAFNGKSYLKE-----HEK 151
Cdd:COG5048  112 ssssnsndnnllSSHSLPPSSRDPQLPDLlsISNLRNNPLPGNNSSSVNtpqsnslhpPLPANSLSKDPSSNlslliSSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 152 IHTGEKPFECSQCGRAFSQKQYLIKHQNIHSGKKPFKCNECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQKSSLI 231
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 232 RHQRSHTGE-------KPYTCKECGKAFSGKSNLTEH--EKIHIGE--KPYKCNE--CGTIFRQKQYLIKHHNIHTGEKP 298
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 299 YEC-------------NKCGKAFSRITSLIVHVRIHTGDKPYECKICGKAFCQSSSLTVHMRSHTGEKPygCNECGKAFS 365
Cdd:COG5048  352 AKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCK--NPPCSKSFN 429

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 755519665 366 QFSTLALHMRIHTGEKPYQCSECGKAFSQK--SHHIRH 401
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLdlSNHGKD 467
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 189-293 4.25e-05

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 45.63  E-value: 4.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 189 CNECGKAFSQKEnliIHQRIHTGEKPYECkGCGkAFIQKSSLIRHQRSHTGEKPYTCKECGKAFSGKS----------NL 258
Cdd:PLN03086 456 CEKCGQAFQQGE---MEKHMKVFHEPLQC-PCG-VVLEKEQMVQHQASTCPLRLITCRFCGDMVQAGGsamdvrdrlrGM 530

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755519665 259 TEHEKIhIGEKPYKCNECGtifrqKQYLIKHHNIH 293
Cdd:PLN03086 531 SEHESI-CGSRTAPCDSCG-----RSVMLKEMDIH 559
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-394 2.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.44e-04
                          10        20
                  ....*....|....*....|....*
gi 755519665  370 LALHMRIHTGEKPYQCSECGKAFSQ 394
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 157-209 5.74e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 5.74e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755519665 157 KPFeCSQCGRAFSQKQYLIKHQNihsgKKPFKCNECGKAFSQKENLIIH-QRIH 209
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
22-401 1.40e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665  22 VYECNECKETFSLEQNFVEHKKTHSGEKSPECTGCGEESSQASSLTLHLRSRPRRESYKcGECGKAFSQRGNFLSHQK-- 99
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPS-DLNSKSLPLSNSKASSSSls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 100 ------------QHTEERPSESKKTPVPM--TTTVRNQRNTGNKPYACK---------ECGKAFNGKSYLKE-----HEK 151
Cdd:COG5048  112 ssssnsndnnllSSHSLPPSSRDPQLPDLlsISNLRNNPLPGNNSSSVNtpqsnslhpPLPANSLSKDPSSNlslliSSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 152 IHTGEKPFECSQCGRAFSQKQYLIKHQNIHSGKKPFKCNECGKAFSQKENLIIHQRIHTGEKPYECKGCGKAFIQKSSLI 231
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 232 RHQRSHTGE-------KPYTCKECGKAFSGKSNLTEH--EKIHIGE--KPYKCNE--CGTIFRQKQYLIKHHNIHTGEKP 298
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 299 YEC-------------NKCGKAFSRITSLIVHVRIHTGDKPYECKICGKAFCQSSSLTVHMRSHTGEKPygCNECGKAFS 365
Cdd:COG5048  352 AKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCK--NPPCSKSFN 429

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 755519665 366 QFSTLALHMRIHTGEKPYQCSECGKAFSQK--SHHIRH 401
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLdlSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-407 4.67e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 4.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 118 TTVRNQRNTGNKPYACKECGKAFNGKSYLKEHEKIHTGEKPFECSQCGRAFSQKQYLIK--HQNIHSGKKPFKCN-ECGK 194
Cdd:COG5048   21 KSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSkSLPL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 195 AFSQKENLIIHQRIHTGEKPYECKGCGKAFIQKSSLIRHQRSHTGEKPYTCKECGKAF---------------------- 252
Cdd:COG5048  101 SNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpanslskdp 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 253 SGKSNLTEHEKIHIGEKPYKCNECGTIFRQKQYLIKHHNIHTGEKPYECNKCGKAFSRI------TSLIVHVRIHTGDKP 326
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 327 YECKICGKAFCQSSSLTVHMRSHTG-EKPYGCNECGKAFSQFSTLALHMR--IHTGE--KPYQCSE--CGKAFSQKSHHI 399
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340


                 ....*...
gi 755519665 400 RHQRIHIH 407
Cdd:COG5048  341 RHILLHTS 348
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 189-293 4.25e-05

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 45.63  E-value: 4.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 189 CNECGKAFSQKEnliIHQRIHTGEKPYECkGCGkAFIQKSSLIRHQRSHTGEKPYTCKECGKAFSGKS----------NL 258
Cdd:PLN03086 456 CEKCGQAFQQGE---MEKHMKVFHEPLQC-PCG-VVLEKEQMVQHQASTCPLRLITCRFCGDMVQAGGsamdvrdrlrGM 530

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755519665 259 TEHEKIhIGEKPYKCNECGtifrqKQYLIKHHNIH 293
Cdd:PLN03086 531 SEHESI-CGSRTAPCDSCG-----RSVMLKEMDIH 559
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-394 2.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.44e-04
                          10        20
                  ....*....|....*....|....*
gi 755519665  370 LALHMRIHTGEKPYQCSECGKAFSQ 394
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 157-209 5.74e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 5.74e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755519665 157 KPFeCSQCGRAFSQKQYLIKHQNihsgKKPFKCNECGKAFSQKENLIIH-QRIH 209
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-253 6.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 6.64e-04
                          10        20
                  ....*....|....*....|....*
gi 755519665  229 SLIRHQRSHTGEKPYTCKECGKAFS 253
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
145-170 7.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.18e-04
                          10        20
                  ....*....|....*....|....*.
gi 755519665  145 YLKEHEKIHTGEKPFECSQCGRAFSQ 170
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 2.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 755519665  201 NLIIHQRIHTGEKPYECKGCGKAFIQ 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 327-349 3.15e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.15e-03
                          10        20
                  ....*....|....*....|...
gi 755519665  327 YECKICGKAFCQSSSLTVHMRSH 349
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 187-209 3.84e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.84e-03
                          10        20
                  ....*....|....*....|...
gi 755519665  187 FKCNECGKAFSQKENLIIHQRIH 209
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 215-237 4.53e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 4.53e-03
                          10        20
                  ....*....|....*....|...
gi 755519665  215 YECKGCGKAFIQKSSLIRHQRSH 237
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 4.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.59e-03
                          10        20
                  ....*....|....*....|....*.
gi 755519665  341 SLTVHMRSHTGEKPYGCNECGKAFSQ 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-205 4.68e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 4.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519665 106 PSESKKTPVPMTTTVRNQRNTGNKPYACK--ECGKAFNGKSYLKEHeKIHtgekpfecSQCGRAFSQKQYLIKHQNIHSG 183
Cdd:COG5189  325 GKLAHGGERNIDTPSRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAK 395

                         90       100
                 ....*....|....*....|..
gi 755519665 184 KKPFKCNECGKAFSQKENLIIH 205
Cdd:COG5189  396 DKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-336 4.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|....
gi 755519665  313 SLIVHVRIHTGDKPYECKICGKAF 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 8.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 8.53e-03
                          10        20
                  ....*....|....*....|....*.
gi 755519665  173 YLIKHQNIHSGKKPFKCNECGKAFSQ 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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