Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 568908781  602 YECDECGKTFIRHDHLTKHKKIH 624
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 568908781  681 SLEMHFRTHSGEKPYKCQICNQSF 704
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781   84 KQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNP---STDVVTLDHVTHSVFQHLLEFLYTSEfFVYKYEIPLVL 160
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQEsesSVSEITLDDVSPEDFEALLEFMYTGK-LISEENVDDLL 84

                          90
                  ....*....|....
gi 568908781  161 EAAKFLDIIDAVKL 174
Cdd:pfam00651  85 AAADKLQIPSLVDK 98

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 568908781  602 YECDECGKTFIRHDHLTKHKKIH 624
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 568908781  681 SLEMHFRTHSGEKPYKCQICNQSF 704
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  88 FCDLLIIVEGKEFSAHKVVVAVGSSYFHACLS---KNPSTDVVTLDHVTHSVFQHLLEFLYTSEFFVYKYEIPLVLEAAK 164
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSsgmKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80

                 ..
gi 568908781 165 FL 166
Cdd:cd18186   81 KL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  72 KNLLKYLNDDRQkQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTDVVTLDHVTHSVFQHLLEFLYTSEFFV 151
Cdd:cd18221    3 KVMLDRLNEQRE-LDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLMV 81

                         90       100
                 ....*....|....*....|....*....
gi 568908781 152 Y-KYEIPLVLEAAKFLDIIDAVKLLNNEN 179
Cdd:cd18221   82 QgEEEANDVWKAAEYLQMQEAIKALEFRN 110

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781    90 DLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPS---TDVVTLDHVTHSVFQHLLEFLYTSEFFVYKYEIPLVLEAAKFL 166
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesdKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*...
gi 568908781   167 DIIDAVKL 174
Cdd:smart00225  81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  70 YNKNLLKYLNDDRqKQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACL------SKNPSTdvVTLDHVTHSVFQHLLEF 143
Cdd:cd18330    1 YYTKLLGELNEQR-KRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLihyiqdSGRHST--ASLDIVTSEAFSIILDF 77

                         90       100
                 ....*....|....*....|....*....
gi 568908781 144 LYTSEFFVYKYEIPLVLEAAKFLDIIDAV 172
Cdd:cd18330   78 LYSGKLDLCSENVIEVMSAASYLQMTDVV 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  69 QYNKNLLKYLNDDRqKQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLS---KNPSTDVVTLDHVTHSVFQHLLEFLY 145
Cdd:cd18256    2 KHASLILAQLNKLR-GQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAggmSESSKDVVQIHGVEPDIFHILLDFIY 80

                         90       100
                 ....*....|....*....|....*....
gi 568908781 146 TSEFFVYKYEIPLVLEAAKFLDIIDAVKL 174
Cdd:cd18256   81 TGVVEVTVSNVQELLVAADMLQLTEVVEI 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  89 CDLLIIVEGKEFSAHKVVVAVGSSYFHACLS-KNPSTDVVTL-DHVTHSVFQHLLEFLYTSEFFVYKYEIPLVLEAAKFL 166
Cdd:cd18955    2 CDVTIVVEDQRFRAHRAVLAACSDYFLSRVVgQTDGDLVITLpEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEFL 81

                 ..
gi 568908781 167 DI 168
Cdd:cd18955   82 GV 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  70 YNKNLLKYLNDDRqKQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKN------PSTdvVTLDHVTHSVFQHLLEF 143
Cdd:cd18199    1 HQSRLLGQLNEQR-KQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYiqdtgrPST--ASFDVFSSDAFSIILDF 77

                         90       100
                 ....*....|....*....|....*....
gi 568908781 144 LYTSEFFVYKYEIPLVLEAAKFLDIIDAV 172
Cdd:cd18199   78 VYSGKLSLTSQNVIEVMSAASYLQMTDVI 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  69 QYNKNLLKYLNDDRQkQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTD---VVTLDHVTHSVFQHLLEFLY 145
Cdd:cd18326    7 DHSSDILSSLNEQRT-QGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDqqnVYEIDFVSAEALTALLDFAY 85

                         90       100
                 ....*....|....*....|...
gi 568908781 146 TSEFFVYKYEIPLVLEAAKFLDI 168
Cdd:cd18326   86 TATLTVSTSNVGDILSAARLLEI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  69 QYNKNLLKYLNDDRqKQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPS---TDVVTLDHVTHSVFQHLLEFLY 145
Cdd:cd18235    3 QHTQKAFDVMNELR-KQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSesrANRVTLQDVDGKALLLLIDYVY 81

                         90       100
                 ....*....|....*....|....*
gi 568908781 146 TSEFFVYKYEIPLVLEAAKFLDIID 170
Cdd:cd18235   82 TAEIQVTEENVQVLLPAANLLQLTD 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  74 LLKYLNDDRQKQpSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLS---KNPSTDVVTLDHVTHSVFQHLLEFLYTSEFF 150
Cdd:cd18255    5 LLQGLNALRAKG-QLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTggmRESSQDEIELKGVSAKGLKHILDFAYTSELT 83

                         90       100
                 ....*....|....*....|....
gi 568908781 151 VYKYEIPLVLEAAKFLDIIDAVKL 174
Cdd:cd18255   84 LDLDCIQDVLGAAVHLQMLPVVEL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  73 NLLKYLNDDRQKQpSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSK--NPSTDVVTLDHVTHSVFQHLLEFLYTSEFF 150
Cdd:cd18209    4 SLLSALNEERLKG-QLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEkeNESQSVFQLDFCEPDAFENVLNYIYSSSLF 82

                         90
                 ....*....|....*...
gi 568908781 151 VYKYEIPLVLEAAKFLDI 168
Cdd:cd18209   83 VEKSSLAAVQELGYSLGI 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  70 YNKNLLKYLNDDRQkQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTD---VVTLDHVTHSVFQHLLEFLYT 146
Cdd:cd18198    8 HSSEILSGLNEQRT-QGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDqqnVYEIDFVSPEALTALLEFAYT 86

                         90       100
                 ....*....|....*....|..
gi 568908781 147 SEFFVYKYEIPLVLEAAKFLDI 168
Cdd:cd18198   87 ATLTVSTANVGDILSAARLLEI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568908781  76 KYLNDdrqkqPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLS---KNPSTDVVTLDHVTHSVFQHLLEFLYT 146
Cdd:cd18297    5 HYVNN-----PEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSsgsTEAQTPVIEIPDIRYDIFQLMMQYLYT 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  78 LNDDRQKQPSFCDL-LIIVEGKE-FSAHKVVVAVGSSYFHACLSKNPSTDVV--TLDHVTHSVFQHLLEFLYTSEFFVYK 153
Cdd:cd18231    4 LNEQRLFQPDLCDVdIVLVRQRStFPAHKGVLAAYSQFFHSLFTQNKQLQRVelSLEALTSQGLQQILNFIYTSKLLVNS 83

                         90
                 ....*....|....*..
gi 568908781 154 YEIPLVLEAAKFLDIID 170
Cdd:cd18231   84 CNVQDVLNAAAVLQMND 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  70 YNKNLLKYLNddRQKQPSF-CDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTDVVTLDHVTHSVFQHLLEFLYTSE 148
Cdd:cd18260    1 YGANLLEGLN--RMRQERFlCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQRVELNDISPLGLATVITYAYTGK 78

                         90       100
                 ....*....|....*....|....*.
gi 568908781 149 FFVYKYEIPLVLEAAKFLDIIDAVKL 174
Cdd:cd18260   79 LTLSLYTIGSTISAASYLQIHALVKM 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  73 NLLKYLNDDRQKQpSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLS---KNPSTDVVTLDHVTHSVFQHLLEFLYTSEF 149
Cdd:cd18250    7 HLLRGLSELRAER-KFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAgelRESRADRVVLHGVSAEILGLLLDFSYTGRV 85

                         90
                 ....*....|....*..
gi 568908781 150 FVYKYEIPLVLEAAKFL 166
Cdd:cd18250   86 TVTQDNVEALLRAADLF 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  70 YNKNLLKYLNDDRQkQPSFCDLLIIVEGKEFSAHKVVVAVGSSYF-HACLSKNpSTDVVTLDHVTHSVFQHLLEFLYTSE 148
Cdd:cd18227    8 FSSTILQKLNQQRQ-QGQLCDISVVVQGHLFRAHKAVLAASSPYFcDQVLLKN-SRRIVLPDVMNPRVFENILLSCYTGR 85

                         90       100
                 ....*....|....*....|
gi 568908781 149 FFVYKYEIPLVLEAAKFLDI 168
Cdd:cd18227   86 LVLPAPEIVSYLTAASFLQM 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  82 RQKQPS-FCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTD----VVTLDHVTHSVFQHLLEFLYTSEFFVYKYEI 156
Cdd:cd18293    8 RQQNSGvFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAgqkvVLELQGLKAHTLLKLVDFLYTSELEVSSEEA 87

                         90
                 ....*....|....*...
gi 568908781 157 PLVLEAAKFLDIIDAVKL 174
Cdd:cd18293   88 QDVLAAARRLQISELESL 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  71 NKNLLKYLNDDRQKQpSFCDLLIIVEGKEFSAHKVVVAVGSSYFHAcLSKNPSTDV-------VTLDHVTHSVFQHLLEF 143
Cdd:cd18258    1 PKEMLKELNQQRRAK-EFTDLKIIVEGKEFEVHQNVLASCSLYFKD-LIKRSSRDSgggekleLTMSNINADVLELLLEF 78

                         90       100
                 ....*....|....*....|...
gi 568908781 144 LYTSEFFVYKYEIPLVLEAA-KF 165
Cdd:cd18258   79 VYTGSLIIDSANAKTLLEAAnKF 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  70 YNKNLLKYLNDDRQKQpSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTDVVtLDHVTHSVFQHLLEFLYTSEF 149
Cdd:cd18232    1 HSVKVLQALNKQREEG-QYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVV-LPESFAEVFGLLLDFFYTGEL 78

                         90       100
                 ....*....|....*....|....*
gi 568908781 150 FVYKYEIPLVLEAAKFLDIIDAVKL 174
Cdd:cd18232   79 ALTRENRDRVLLAAKELRVPEAVEL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  70 YNKNLLKYLNDDRQKQpSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNpstDVVTLDH--VTHSVFQHLLEFLYTS 147
Cdd:cd18216    3 HATQLLLQLNNQRTKG-FLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHD---NLIHLDQdmVSPTVFQQILDFIYTG 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 568908781 148 EFFVYKYEIP---LVLEAAKFLDIIDAVKL 174
Cdd:cd18216   79 KLLDSLFEEPnlsEVLAAANYLQLPDLAAL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  69 QYNKNLLKYLNDDRQkQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTDVVTLDHVTHSVFQHLLEFLYTSE 148
Cdd:cd18222    7 DFSNSVLSHLNQLRM-QGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPTVFEQLLSFCYTGR 85

                         90       100
                 ....*....|....*....|
gi 568908781 149 FFVYKYEIPLVLEAAKFLDI 168
Cdd:cd18222   86 ICLQLADIISYLTAASFLQM 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  69 QYNKNLLKYLNDDRQkQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPS---TDVVTLDHVTHSVFQHLLEFLY 145
Cdd:cd18338    3 RHMKKAFKVMNELRS-QNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSesrAKRVRIKEVDGWTLKMLIDYVY 81

                         90       100
                 ....*....|....*....|....*...
gi 568908781 146 TSEFFVYKYEIPLVLEAAKFLDIIDAVK 173
Cdd:cd18338   82 TAEIQVTEENVQVLLPAAGLLQLQDVKK 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568908781  69 QYNKNLLKYLNDDRQKQpSFCDLLIIVEGKEFSAHKVVVAVGSSYF----------HACLSKNPSTDVVTLDHVTHSVFQ 138
Cdd:cd18327    7 EHSSELLSCLNEQRRAG-LLCDLTIKTRGLEYRTHRAVLAACSLYFrklftgggggSGDLGAGGGQDVCELDFVGPEALG 85

                         90       100       110
                 ....*....|....*....|....*....|
gi 568908781 139 HLLEFLYTSEFFVYKYEIPLVLEAAKFLDI 168
Cdd:cd18327   86 ALLEFAYTATLTISSSNMREVLRAARLLEI 115