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Conserved domains on  [gi|569010004|ref|XP_006528030|]
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zinc finger X-chromosomal protein isoform X3 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein; C2H2-type zinc finger protein; C2H2-type zinc finger protein; C2H2-type zinc finger protein; KRAB domain-containing zinc finger protein; C2H2-type zinc finger protein; KRAB domain-containing zinc finger protein; KRAB domain-containing zinc finger protein( domain architecture ID 12656255)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Mus musculus zinc finger protein 574 (ZNF574); Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Homo sapiens zinc finger protein 513 (ZNF513), a transcriptional regulator that plays a role in retinal development and maintenance; KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Mus musculus zinc finger protein 574 (ZNF574); Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Homo sapiens zinc finger protein 648 (ZNF648); Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription; Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Mus musculus Krueppel-like factor 10 isoform 2, which suppresses TGFbeta-induced EMT, establishing a molecular basis for the dichotomy of TGFbeta function during tumor progression; KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 104-387 2.57e-152

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


:

Pssm-ID: 461400  Cd Length: 328  Bit Score: 447.39  E-value: 2.57e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  104 DVVIEDVQCTDIMDEADVSETVIIPEQVLDSDVTEEVSLTHCTVPDDVLASDITSASISMPEHVLTSESIHVSDVGHVEH 183
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  184 VVHDSvvEAEIVTDPLAADVVSEEVLVADCASEAVIDANGIPVNQQDEEKNNCEDYLMISC------------------- 244
Cdd:pfam04704  81 VIHDS--EREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLddgekldhigstpltmsae 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  245 -------------------------------GTVDIVESEPENEHGVELLDPNNSIRVPREKMVYMAVNDSQQEEEELNV 293
Cdd:pfam04704 159 veqdsskldgfcpevikvyifkadpgeddlgGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQEDEDLNV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  294 AEIADEVYMEVIVGEEDaaaaaAAAVHEQQVEDNEM-KTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAK 372
Cdd:pfam04704 239 AEIADEVYMEVIVGEED-----AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESASLDRLLK 313

                         330
                  ....*....|....*
gi 569010004  373 QKPKKRRRPDSRQYQ 387
Cdd:pfam04704 314 QKPKKKRRGESRQYQ 328
zf-H2C2_2 pfam13465
Zinc-finger double domain;
539-563 4.52e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.52e-05
                          10        20
                  ....*....|....*....|....*
gi 569010004  539 ELKKHMRIHTGEKPYECQYCEYRSA 563
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
520-644 7.41e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 7.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004 520 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYECQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 597
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 569010004 598 QQHALVHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC 644
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN 154
ROS_MUCR super family cl19880
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 354-434 4.75e-04

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


The actual alignment was detected with superfamily member pfam05443:

Pssm-ID: 473244  Cd Length: 122  Bit Score: 40.52  E-value: 4.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  354 TASALLHIDESAGLGRLAKQKP----KKRRRPDSrqyqtaiIIgpdghpltvypCMICGKKFKSrgfLKRHMKNHpeHLA 429
Cdd:pfam05443  31 VHAALAGLGEGAAPPAEEEPVPavpiKKSITPDY-------II-----------CLEDGKPFKT---LKRHLTAH--GLT 87


                  ....*
gi 569010004  430 KKKYR 434
Cdd:pfam05443  88 PEEYR 92
zf-H2C2_2 pfam13465
Zinc-finger double domain;
710-734 7.55e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.55e-04
                          10        20
                  ....*....|....*....|....*
gi 569010004  710 ELKKHMKTHSGRKVYQCEYCEYSTT 734
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 696-718 1.41e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.41e-03
                          10        20
                  ....*....|....*....|...
gi 569010004  696 FRCKRCRKGFRQQSELKKHMKTH 718
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 104-387 2.57e-152

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 447.39  E-value: 2.57e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  104 DVVIEDVQCTDIMDEADVSETVIIPEQVLDSDVTEEVSLTHCTVPDDVLASDITSASISMPEHVLTSESIHVSDVGHVEH 183
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  184 VVHDSvvEAEIVTDPLAADVVSEEVLVADCASEAVIDANGIPVNQQDEEKNNCEDYLMISC------------------- 244
Cdd:pfam04704  81 VIHDS--EREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLddgekldhigstpltmsae 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  245 -------------------------------GTVDIVESEPENEHGVELLDPNNSIRVPREKMVYMAVNDSQQEEEELNV 293
Cdd:pfam04704 159 veqdsskldgfcpevikvyifkadpgeddlgGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQEDEDLNV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  294 AEIADEVYMEVIVGEEDaaaaaAAAVHEQQVEDNEM-KTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAK 372
Cdd:pfam04704 239 AEIADEVYMEVIVGEED-----AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESASLDRLLK 313

                         330
                  ....*....|....*
gi 569010004  373 QKPKKRRRPDSRQYQ 387
Cdd:pfam04704 314 QKPKKKRRGESRQYQ 328
zf-H2C2_2 pfam13465
Zinc-finger double domain;
539-563 4.52e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.52e-05
                          10        20
                  ....*....|....*....|....*
gi 569010004  539 ELKKHMRIHTGEKPYECQYCEYRSA 563
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
520-644 7.41e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 7.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004 520 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYECQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 597
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 569010004 598 QQHALVHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC 644
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN 154
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 354-434 4.75e-04

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 40.52  E-value: 4.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  354 TASALLHIDESAGLGRLAKQKP----KKRRRPDSrqyqtaiIIgpdghpltvypCMICGKKFKSrgfLKRHMKNHpeHLA 429
Cdd:pfam05443  31 VHAALAGLGEGAAPPAEEEPVPavpiKKSITPDY-------II-----------CLEDGKPFKT---LKRHLTAH--GLT 87


                  ....*
gi 569010004  430 KKKYR 434
Cdd:pfam05443  88 PEEYR 92
rne PRK10811
ribonuclease E; Reviewed
 66-234 6.51e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 43.49  E-value: 6.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004   66 VVEVQETVYVSDVVDSDITVHNYVPDDPDSVVIQDVIEDVVIEDVqcTDIMDEADVSETVIIPEQVLDSDVTEEVSLTHC 145
Cdd:PRK10811  847 VVRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAV--AEVVEEPVVVAEPQPEEVVVVETTHPEVIAAPV 924

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  146 TVPDDVLASDITSASISMPEHV--LTSESIHVSDVGHVEHVVHDSVVEAEIVTDPLAADVVSEEVLVAD--CASEAVIDA 221
Cdd:PRK10811  925 TEQPQVITESDVAVAQEVAEHAepVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETvtAVEPEVAPA 1004

                         170
                  ....*....|...
gi 569010004  222 ngiPVNQQDEEKN 234
Cdd:PRK10811 1005 ---QVPEATVEHN 1014
zf-H2C2_2 pfam13465
Zinc-finger double domain;
710-734 7.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.55e-04
                          10        20
                  ....*....|....*....|....*
gi 569010004  710 ELKKHMKTHSGRKVYQCEYCEYSTT 734
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 696-718 1.41e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.41e-03
                          10        20
                  ....*....|....*....|...
gi 569010004  696 FRCKRCRKGFRQQSELKKHMKTH 718
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 525-547 1.44e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|...
gi 569010004  525 HICVECGKGFRHPSELKKHMRIH 547
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 104-387 2.57e-152

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 447.39  E-value: 2.57e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  104 DVVIEDVQCTDIMDEADVSETVIIPEQVLDSDVTEEVSLTHCTVPDDVLASDITSASISMPEHVLTSESIHVSDVGHVEH 183
Cdd:pfam04704   1 DVVIEDVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLEH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  184 VVHDSvvEAEIVTDPLAADVVSEEVLVADCASEAVIDANGIPVNQQDEEKNNCEDYLMISC------------------- 244
Cdd:pfam04704  81 VIHDS--EREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLddgekldhigstpltmsae 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  245 -------------------------------GTVDIVESEPENEHGVELLDPNNSIRVPREKMVYMAVNDSQQEEEELNV 293
Cdd:pfam04704 159 veqdsskldgfcpevikvyifkadpgeddlgGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQEDEDLNV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  294 AEIADEVYMEVIVGEEDaaaaaAAAVHEQQVEDNEM-KTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRLAK 372
Cdd:pfam04704 239 AEIADEVYMEVIVGEED-----AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESASLDRLLK 313

                         330
                  ....*....|....*
gi 569010004  373 QKPKKRRRPDSRQYQ 387
Cdd:pfam04704 314 QKPKKKRRGESRQYQ 328
zf-H2C2_2 pfam13465
Zinc-finger double domain;
539-563 4.52e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.52e-05
                          10        20
                  ....*....|....*....|....*
gi 569010004  539 ELKKHMRIHTGEKPYECQYCEYRSA 563
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
520-644 7.41e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 7.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004 520 SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYECQYCEYRSA--DSSNLKTHVkTKHSKEMPFKCDICLLTFSDTKEV 597
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsRPLELSRHL-RTHHNNPSDLNSKSLPLSNSKASS 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 569010004 598 QQHALVHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMC 644
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN 154
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 354-434 4.75e-04

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 40.52  E-value: 4.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  354 TASALLHIDESAGLGRLAKQKP----KKRRRPDSrqyqtaiIIgpdghpltvypCMICGKKFKSrgfLKRHMKNHpeHLA 429
Cdd:pfam05443  31 VHAALAGLGEGAAPPAEEEPVPavpiKKSITPDY-------II-----------CLEDGKPFKT---LKRHLTAH--GLT 87


                  ....*
gi 569010004  430 KKKYR 434
Cdd:pfam05443  88 PEEYR 92
rne PRK10811
ribonuclease E; Reviewed
 66-234 6.51e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 43.49  E-value: 6.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004   66 VVEVQETVYVSDVVDSDITVHNYVPDDPDSVVIQDVIEDVVIEDVqcTDIMDEADVSETVIIPEQVLDSDVTEEVSLTHC 145
Cdd:PRK10811  847 VVRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAV--AEVVEEPVVVAEPQPEEVVVVETTHPEVIAAPV 924

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010004  146 TVPDDVLASDITSASISMPEHV--LTSESIHVSDVGHVEHVVHDSVVEAEIVTDPLAADVVSEEVLVAD--CASEAVIDA 221
Cdd:PRK10811  925 TEQPQVITESDVAVAQEVAEHAepVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETvtAVEPEVAPA 1004

                         170
                  ....*....|...
gi 569010004  222 ngiPVNQQDEEKN 234
Cdd:PRK10811 1005 ---QVPEATVEHN 1014
zf-H2C2_2 pfam13465
Zinc-finger double domain;
710-734 7.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.55e-04
                          10        20
                  ....*....|....*....|....*
gi 569010004  710 ELKKHMKTHSGRKVYQCEYCEYSTT 734
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 696-718 1.41e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.41e-03
                          10        20
                  ....*....|....*....|...
gi 569010004  696 FRCKRCRKGFRQQSELKKHMKTH 718
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 525-547 1.44e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|...
gi 569010004  525 HICVECGKGFRHPSELKKHMRIH 547
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 402-424 7.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.47e-03
                          10        20
                  ....*....|....*....|...
gi 569010004  402 YPCMICGKKFKSRGFLKRHMKNH 424
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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