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Conserved domains on  [gi|569006864|ref|XP_006526966|]
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beta-tectorin isoform X2 [Mus musculus]

Protein Classification

zona pellucida domain-containing protein( domain architecture ID 1903244)

zona pellucida (ZP) domain-containing protein may function as a structural component of egg coats, appendicularian mucous houses, and nematode dauer larvae, or as a mechanotransducer in flies, or as a receptor in mammals and nonmammals

Gene Ontology:  GO:0031012

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ZP super family cl42957
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
32-283 8.44e-43

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


The actual alignment was detected with superfamily member smart00241:

Pssm-ID: 214579  Cd Length: 252  Bit Score: 148.30  E-value: 8.44e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864    32 CYPKTIITKIPECPYGW---EVHQLALGG-LCYNgvHEGGYYQFVIPDLSPKNKsyCGTQSEYKPPIYHFYSHIVSN--D 105
Cdd:smart00241   2 CGEDQMVVSVSTDLLFPggiNVKGLTLGDpSCRP--QFTDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVVSpfH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864   106 STVIVKNQPVNYSFSCTYHSTYLVNQAAFDQRVATVHVKNGSMGTFesQLSLNFYTNAKFSTKKEAPFVletsEIGSDLF 185
Cdd:smart00241  78 PGFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTELSSVSEGPL--TCSYRLYKDDSFGSPYQSADY----VLGDPVY 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864   186 AGVEAKG-LSVRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDE---TVLVHENGKDHRATFQFNAFRFQNIpklSKVW 261
Cdd:smart00241 152 HEWECDGaDDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGyldSTIPYNSNPLHRARFSVKVFKFADR---SLVY 228
                          250       260
                   ....*....|....*....|....
gi 569006864   262 LHCETFICDSEK-LSCP-VNCDKR 283
Cdd:smart00241 229 FHCQIRLCDKDDgSSCDgPACSSR 252
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
32-283 8.44e-43

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 148.30  E-value: 8.44e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864    32 CYPKTIITKIPECPYGW---EVHQLALGG-LCYNgvHEGGYYQFVIPDLSPKNKsyCGTQSEYKPPIYHFYSHIVSN--D 105
Cdd:smart00241   2 CGEDQMVVSVSTDLLFPggiNVKGLTLGDpSCRP--QFTDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVVSpfH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864   106 STVIVKNQPVNYSFSCTYHSTYLVNQAAFDQRVATVHVKNGSMGTFesQLSLNFYTNAKFSTKKEAPFVletsEIGSDLF 185
Cdd:smart00241  78 PGFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTELSSVSEGPL--TCSYRLYKDDSFGSPYQSADY----VLGDPVY 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864   186 AGVEAKG-LSVRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDE---TVLVHENGKDHRATFQFNAFRFQNIpklSKVW 261
Cdd:smart00241 152 HEWECDGaDDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGyldSTIPYNSNPLHRARFSVKVFKFADR---SLVY 228
                          250       260
                   ....*....|....*....|....
gi 569006864   262 LHCETFICDSEK-LSCP-VNCDKR 283
Cdd:smart00241 229 FHCQIRLCDKDDgSSCDgPACSSR 252
Zona_pellucida pfam00100
Zona pellucida-like domain;
20-280 4.06e-34

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 125.41  E-value: 4.06e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864   20 CTPNKADVILVFCYPKTiitkipecpyGWEVHQLALGGL----CYNGVHEGGYYQFVIPdlSPKNKsyCGTQSEYKPPIY 95
Cdd:pfam00100   1 CTPDTMTVSISKCLLVP----------SGLLSSLSLLGGldpsCKPVSNTNGSPAVLFE--FPLTG--CGTTVQVNGTHI 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864   96 HFYSHIVSN---DSTVIVKNQPVNYSFSCTYHSTYLVNQAAFDQRVATVHVKNGSmGTFesQLSLNFYTNAKFSTKKEAP 172
Cdd:pfam00100  67 IYSNTLYSStdlRSGIIRRTITRRLPFSCSYPRSSLVSLLVVAPPSPVPITVSGS-GVF--LVSMDLYYDSSYTSPYSPY 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864  173 FVleTSEIGSDLFAGVEAKGLS-VRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDET----VLVHENGKDHRATFQFN 247
Cdd:pfam00100 144 PV--TVLLGDPLYVEVSLLSRTdPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDstypVSSLSNGPSHYVRFSFK 221
                         250       260       270
                  ....*....|....*....|....*....|...
gi 569006864  248 AFRFQNIPKlSKVWLHCETFICDSEKLSCPVNC 280
Cdd:pfam00100 222 AFRFVGSSI-SQVYLHCSVSVCSSDSNSCGKSC 253
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
32-283 8.44e-43

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 148.30  E-value: 8.44e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864    32 CYPKTIITKIPECPYGW---EVHQLALGG-LCYNgvHEGGYYQFVIPDLSPKNKsyCGTQSEYKPPIYHFYSHIVSN--D 105
Cdd:smart00241   2 CGEDQMVVSVSTDLLFPggiNVKGLTLGDpSCRP--QFTDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVVSpfH 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864   106 STVIVKNQPVNYSFSCTYHSTYLVNQAAFDQRVATVHVKNGSMGTFesQLSLNFYTNAKFSTKKEAPFVletsEIGSDLF 185
Cdd:smart00241  78 PGFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTELSSVSEGPL--TCSYRLYKDDSFGSPYQSADY----VLGDPVY 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864   186 AGVEAKG-LSVRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDE---TVLVHENGKDHRATFQFNAFRFQNIpklSKVW 261
Cdd:smart00241 152 HEWECDGaDDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGyldSTIPYNSNPLHRARFSVKVFKFADR---SLVY 228
                          250       260
                   ....*....|....*....|....
gi 569006864   262 LHCETFICDSEK-LSCP-VNCDKR 283
Cdd:smart00241 229 FHCQIRLCDKDDgSSCDgPACSSR 252
Zona_pellucida pfam00100
Zona pellucida-like domain;
20-280 4.06e-34

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 125.41  E-value: 4.06e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864   20 CTPNKADVILVFCYPKTiitkipecpyGWEVHQLALGGL----CYNGVHEGGYYQFVIPdlSPKNKsyCGTQSEYKPPIY 95
Cdd:pfam00100   1 CTPDTMTVSISKCLLVP----------SGLLSSLSLLGGldpsCKPVSNTNGSPAVLFE--FPLTG--CGTTVQVNGTHI 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864   96 HFYSHIVSN---DSTVIVKNQPVNYSFSCTYHSTYLVNQAAFDQRVATVHVKNGSmGTFesQLSLNFYTNAKFSTKKEAP 172
Cdd:pfam00100  67 IYSNTLYSStdlRSGIIRRTITRRLPFSCSYPRSSLVSLLVVAPPSPVPITVSGS-GVF--LVSMDLYYDSSYTSPYSPY 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006864  173 FVleTSEIGSDLFAGVEAKGLS-VRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDET----VLVHENGKDHRATFQFN 247
Cdd:pfam00100 144 PV--TVLLGDPLYVEVSLLSRTdPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDstypVSSLSNGPSHYVRFSFK 221
                         250       260       270
                  ....*....|....*....|....*....|...
gi 569006864  248 AFRFQNIPKlSKVWLHCETFICDSEKLSCPVNC 280
Cdd:pfam00100 222 AFRFVGSSI-SQVYLHCSVSVCSSDSNSCGKSC 253
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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