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Conserved domains on  [gi|568980130|ref|XP_006516166|]
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probable G-protein coupled receptor 132 isoform X1 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
46-317 7.70e-142

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15364:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 279  Bit Score: 404.16  E-value: 7.70e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15364    7 YSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIFFCNIYI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMK----VEKSFCFEPLRMNSKIAGYHYLR 201
Cdd:cd15364   87 SILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIMRegqtEGSHTCFETLQMDTQVAGFYYAR 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 202 FTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQgdmDAVCAFE 281
Cdd:cd15364  167 FCIGFAIPLAILIFTNYRIFRSIQTSTSLTPHQKAKVKYLAIAVIVIFLICFAPYHLVLLVRAIAFSLYP---NGMCGFE 243
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568980130 282 SRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15364  244 ERIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
 
Name Accession Description Interval E-value
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
46-317 7.70e-142

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 404.16  E-value: 7.70e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15364    7 YSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIFFCNIYI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMK----VEKSFCFEPLRMNSKIAGYHYLR 201
Cdd:cd15364   87 SILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIMRegqtEGSHTCFETLQMDTQVAGFYYAR 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 202 FTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQgdmDAVCAFE 281
Cdd:cd15364  167 FCIGFAIPLAILIFTNYRIFRSIQTSTSLTPHQKAKVKYLAIAVIVIFLICFAPYHLVLLVRAIAFSLYP---NGMCGFE 243
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568980130 282 SRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15364  244 ERIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
57-306 8.79e-37

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 133.96  E-value: 8.79e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130   57 NCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISC 135
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  136 DRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDM-------KVEKSFCFE-PLRMNSKIAGYHYLRFTFGFA 207
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFgwtltvpEGNVTVCFIdFPEDLSKPVSYTLLISVLGFL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  208 IPLGILAFTNHQIFRSI-----KLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSfyqgdmdavCAFES 282
Cdd:pfam00001 162 LPLLVILVCYTLIIRTLrksasKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALD---------CELSR 232
                         250       260
                  ....*....|....*....|....
gi 568980130  283 RLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:pfam00001 233 LLDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
33-308 3.28e-19

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 87.53  E-value: 3.28e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  33 VSYEESRVVLVVVYSAVCLLGLPANcLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQhKWNLGPQAC 112
Cdd:PHA03087  34 IGYDTNSTILIVVYSTIFFFGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILF-QWSFGEFAC 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 113 KVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKS-----FCFEP 187
Cdd:PHA03087 112 KIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKdhetlICCMF 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 188 LRMNSKI--AGYHYLRFTFGFAIPLGILAFTNHQIFrsIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAA 265
Cdd:PHA03087 192 YNNKTMNwkLFINFEINIIGMLIPLTILLYCYSKIL--ITLKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSL 269
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568980130 266 -SFSFYQGdmdavCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:PHA03087 270 hILHFKSG-----CKAVKYIQYALHVTEIISLSHCCINPLIYAF 308
 
Name Accession Description Interval E-value
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
46-317 7.70e-142

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 404.16  E-value: 7.70e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15364    7 YSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIFFCNIYI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMK----VEKSFCFEPLRMNSKIAGYHYLR 201
Cdd:cd15364   87 SILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIMRegqtEGSHTCFETLQMDTQVAGFYYAR 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 202 FTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQgdmDAVCAFE 281
Cdd:cd15364  167 FCIGFAIPLAILIFTNYRIFRSIQTSTSLTPHQKAKVKYLAIAVIVIFLICFAPYHLVLLVRAIAFSLYP---NGMCGFE 243
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568980130 282 SRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15364  244 ERIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
46-317 4.09e-108

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 318.56  E-value: 4.09e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15160    7 YSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGFFFYTNIYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFD------MKVEKSFCFEPLRMNSKIAGYHY 199
Cdd:cd15160   87 SIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGhdelfrDEPNHTLCYEKYPMEGWQASYNY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 LRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDmdavCA 279
Cdd:cd15160  167 ARFLVGFLIPLSLILFFYRRVLRAVRQSPSLEREEKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELVQNGL----CG 242
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568980130 280 FESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15160  243 FEKRVFTAYQISLCLTSLNCVADPILYIFVTEDVRQDL 280
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
46-317 2.07e-67

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 214.66  E-value: 2.07e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15366    7 YIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFYTNIYI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILL------VGLVNYPVFDMKVEKSFCFEPLRMNSKIAGYHY 199
Cdd:cd15366   87 SIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIeigansAPLFHDELFRDRYNHTFCFEKYPMEDWVAWMNL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 LRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDmdavCA 279
Cdd:cd15366  167 YRVFVGFLFPWVLMLFSYRGILRAVRGNVSTEQQEKAKIKRLALSLIAIVLLCFAPYHVLLLSRSVVYLGKPCD----CG 242
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568980130 280 FESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15366  243 FEERVFTAYHVSLALTSLNCVADPILYCLVNEGARSDV 280
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
46-317 5.24e-57

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 187.86  E-value: 5.24e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd14982    7 YSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFYINMYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDM------KVEKSFCFEPLRMNSKIA-GYH 198
Cdd:cd14982   87 SILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLrstiakENNSTTCFEFLSEWLASAaPIV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVK--RSAIAVVTIFLVCFAPYHVVLLVkaasFSFYQGDMDA 276
Cdd:cd14982  167 LIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKRKalRMILIVLAVFLVCFLPYHVTRIL----YLLVRLSFIA 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568980130 277 VCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd14982  243 DCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
46-306 3.10e-49

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 167.25  E-value: 3.10e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15367    7 YILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHDNWTYSELLCKICGILLYENIYI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKV------EKSFCFEPLRMNSKIAGYHY 199
Cdd:cd15367   87 SIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTCVFFFLHGEiskdkeNHSVCFEHYPIKAWEHNINY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 LRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKaasfSFYQGDmdavCA 279
Cdd:cd15367  167 YRFYAGFLFPIFLLSFSYCRILRAVRKSHGTQKSQKIQIKRLVLSTVVIFLVCFGPYHILLLVR----SVFERD----CN 238
                        250       260
                 ....*....|....*....|....*..
gi 568980130 280 FESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15367  239 FAEGIFNYYHFSLLLTSFNCVADPVLY 265
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
46-317 9.01e-49

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 166.11  E-value: 9.01e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15365    7 YIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLLYTNFYT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF---DMKVEKS---FCFEPLRMNSKIAGYHY 199
Cdd:cd15365   87 STALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILtweDSFHESSshtLCYDKFPLEDWQARLNL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 LRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASfsfyqgdMDAVCA 279
Cdd:cd15365  167 FRICLGYLLPLLIILFCYWKIYQAVRSNQATEDQEKKKIFKLLLLITVTFVICFTPYHVVLLIRSIV-------EPCDCR 239
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568980130 280 FESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15365  240 NAKWLYTLYKITVALTSLNCIADPFLYCFVTESGRADI 277
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
46-308 1.16e-38

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 139.82  E-value: 1.16e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd14985    7 YIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVISVNMFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMK-------VEKSFCFEPLRMNSKIAGYH 198
Cdd:cd14985   87 SIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRslqaienLNKTACIMLYPHEAWHFGLS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSaaQKNKVKRS-----AIAVVTIFLVCFAPYHVVllvkaaSFSFYQGD 273
Cdd:cd14985  167 LELNILGFVLPLLIILTCYFHIARSLRKRYERT--GKNGRKRRkslkiIFALVVAFLVCWLPFHFF------KFLDFLAQ 238
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568980130 274 MDAV--CAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd14985  239 LGAIrpCFWELFLDLGLPIATCLAFTNSCLNPFIYVF 275
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
57-306 8.79e-37

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 133.96  E-value: 8.79e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130   57 NCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISC 135
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  136 DRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDM-------KVEKSFCFE-PLRMNSKIAGYHYLRFTFGFA 207
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFgwtltvpEGNVTVCFIdFPEDLSKPVSYTLLISVLGFL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  208 IPLGILAFTNHQIFRSI-----KLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSfyqgdmdavCAFES 282
Cdd:pfam00001 162 LPLLVILVCYTLIIRTLrksasKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALD---------CELSR 232
                         250       260
                  ....*....|....*....|....
gi 568980130  283 RLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:pfam00001 233 LLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
46-315 1.39e-36

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 134.37  E-value: 1.39e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15168    7 YGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFLFYFNLYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFdmkveksFCFEPLRMNSKIAGY-------- 197
Cdd:cd15168   87 SILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPIL-------FFATTGRKNNRTTCYdttspeel 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 -HYLRFTF-----GFAIPLGILAFTNHQIFRSI--KLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVvllVKAASFSF 269
Cdd:cd15168  160 nDYVIYSMvltglGFLLPLLIILACYGLIVRALirKLGEGVTSALRRKSIRLVIIVLALFAVCFLPFHV---TRTINLAA 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568980130 270 YQGDMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15168  237 RLLSGTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFRR 282
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
46-317 1.36e-33

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 126.02  E-value: 1.36e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15162    7 YTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFYGNMYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVE-------KSFCFE--PLRMNSKIAG 196
Cdd:cd15162   87 SILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTiflpaldITTCHDvlPEQLLVGDWF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 YHYLRFTF-GFAIPLGILAFTNHQIFRS-IKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFyqgdm 274
Cdd:cd15162  167 YYFLSLAIvGFLIPFILTASCYVATIRTlAALEDENSEKKKKRAIKLAATVLAIFIICFAPSNLLLLAHYSLISS----- 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568980130 275 davcAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15162  242 ----SGTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
46-308 3.32e-33

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 125.09  E-value: 3.32e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIY 124
Cdd:cd00637    5 YILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVgLLVIPFSLVSLLLGR-WWFGDALCKLLGFLQSVSLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF-----DMKVEKSFCFEPLRMNSKIAGYHY 199
Cdd:cd00637   84 ASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLlgwgvYDYGGYCCCCLCWPDLTLSKAYTI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 LRFTFGFAIPLGILAFTNHQIFRSIK------------LSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASF 267
Cdd:cd00637  164 FLFVLLFLLPLLVIIVCYVRIFRKLRrhrrrirssssnSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGP 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568980130 268 SFYQgdmdavcafesRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd00637  244 DPSP-----------LPRILYFLALLLAYLNSAINPIIYAF 273
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
46-317 1.74e-32

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 123.48  E-value: 1.74e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15377    7 YILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFdmkvekSFCFEPLRMNSKIAGY-----HYL 200
Cdd:cd15377   87 SILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPIL------FYSGTGVRKNKTITCYdttsdEYL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 201 R---------FTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRS-----AIAVVTIFLVCFAPYHVV-LLVKAA 265
Cdd:cd15377  161 RsyfiysmctTVAMFCVPFILILGCYGLIVRALIYKDMKYTEENNAPLRRksiylVIIVLTVFAVSYLPFHVMkTLNLRA 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568980130 266 SFSFYQGDMdavCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15377  241 RLDFQTPAM---CAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
46-306 5.12e-32

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 121.74  E-value: 5.12e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15161    7 YILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLFYLNMYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMK--VEKSFCFEPLRMNSKIAGYHYL-RF 202
Cdd:cd15161   87 SLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPqtVEVNNTTVCLQLYREKASRGALvSL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 203 TFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVkaasFSFYQGDMDAVCAFES 282
Cdd:cd15161  167 AVAFTIPFVTTVTCYLLIIRSLRTGKREEKPLKDKAIKMIILVLTIFLICFVPYHISRYI----YILSHNGAGASCSSRR 242
                        250       260
                 ....*....|....*....|....
gi 568980130 283 RLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15161  243 GLALANRITSCLTCLNGALDPVMY 266
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
46-306 2.01e-31

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 120.41  E-value: 2.01e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15155    7 YSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRH-WPFGDSLCKISGTAFLTNIYG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLV--GLVNYPVF---DMKVEKSFCFEPLrmnSKIAGYHYL 200
Cdd:cd15155   86 SMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVlsGGISASLFsttNVSNTSTTCFEGF---SKSIWKTYL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 201 -RFTF-----GFAIPLGILAFTNHQIFRSIKLSDSLS--AAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVkaasFSFYQG 272
Cdd:cd15155  163 sKITIfievvGFIIPLLLNLTCSSLVLRTLRKPATLSqiGTNKEKVLKMILVHVAIFVVCFVPYNSILFL----YALVRS 238
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568980130 273 DMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15155  239 QAIANCGVERFARTMYPITLCLATLNCCFDPFVY 272
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
46-262 1.08e-30

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 118.15  E-value: 1.08e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQhkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15178    7 YVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVKG--WIFGTFMCKLVSLLQEANFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHqRTAVTISACVILLVGLVNYPVF---DMKVEKSF----CFEPLRMNSKIA--- 195
Cdd:cd15178   85 GILLLACISVDRYLAIVHATRALTQKR-HLVKFVCAGVWLLSLLLSLPALlnrDAFKPPNSgrtvCYENLGNESADKwrv 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568980130 196 GYHYLRFTFGFAIPLGILAF----TNHQIFRSiklsdslSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLV 262
Cdd:cd15178  164 VLRILRHTLGFLLPLVVMLFcygfTIKTLLQT-------RSFQKHRAMRVIFAVVLAFLLCWLPYNVTVLI 227
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
46-314 4.79e-30

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 116.72  E-value: 4.79e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQ-RNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15376    7 LGVEFLVAVLGNGLALWLFVTRERRpWHTGVVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFTCNLY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF---DMKVEKSFCFEPLRMNSKIAGYHYLR 201
Cdd:cd15376   87 GSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPVLsfsHLEVERHNKTECLGTAVDSRLPTYLP 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 202 FT-----FGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVkaasfSFYQGDMDA 276
Cdd:cd15376  167 YSlflavVGCGLPFLLTLASYLAIVWAVLRSPGITTLEKRKVAALVAVVVALYAVSFVPYHILRNL-----NLYRRLQWL 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568980130 277 VCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSR 314
Cdd:cd15376  242 KAAASLRIYFAYQVTKGLVTLNMCIHPLLYMAVADSIR 279
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
46-315 5.53e-30

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 116.41  E-value: 5.53e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15368    7 YSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLFYANMYS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPV------FDMK-VEKSFCFEPLRMN-----SK 193
Cdd:cd15368   87 SILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLertdltYYVKeLNITTCFDVLKWTmlpniAA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 194 IAGYHYLRFTFGFAIPLGILAFTNHQIFRS-IKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQG 272
Cdd:cd15368  167 WAAFLFTLFILLFLIPFIITVYCYVLIILKlVQTSERYGREQKRRAIYLALIVLLVFITCFAPNNFILLAHMVSRLFYGK 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568980130 273 DmdavcafesrLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15368  247 S----------LYHAYKLTLSLSCLNSCLDPFIYYFASKEFRK 279
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
46-317 3.71e-29

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 114.09  E-value: 3.71e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15369    7 YTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGNDWLFGEAMCRVVTAAFYCNMYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDM-------KVEKSFCFEPLRMNSKIAGYH 198
Cdd:cd15369   87 SILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSeqtiqipDLGITTCHDVLNEQLLMGYYV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFG---FAIPLGILAFTNHQIFRSikLSDSLSAAQKNKVKRS---AIAVVTIFLVCFAPYHVVLLVKAASFSfYQG 272
Cdd:cd15369  167 YYFSIFSclfFFVPLIITTVCYVSIIRC--LSSSSDVANSSKKTRAlfmAVAVFCVFVICFGPTNVLLLAHYVRFA-YTS 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 568980130 273 DMDAvcafesrLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15369  244 TNDA-------SYFAYLLCVCVGSISCCLDPLIYYYGSSQCQKQL 281
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
46-317 1.11e-28

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 112.92  E-value: 1.11e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVlQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15372    7 YTLVFLVGLPANGLALWVLATQV-KRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNMYC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMK-------VEKSFCFEPLRMNSKiAGYH 198
Cdd:cd15372   86 SVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRqsyplerLNITLCHDVLPLDEQ-DTYL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFT----FGFAIPLGILAFTNHQIFRSIklsdSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDm 274
Cdd:cd15372  165 FYYFAclavLGFLLPLVVILFCYGSVLHTL----LRSGQRYGHAMKLTVLVLVSFVLCFTPSNLLLLLHYSDPTLDDGG- 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568980130 275 davcafesRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15372  240 --------NLYIVYMVSLAISTLNSCVDPFIYYYVSEEFRDKV 274
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
46-307 2.81e-28

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 111.54  E-value: 2.81e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQhkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd14984    7 YSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAADG--WVFGSFLCKLVSALYTINFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFdMKVEKSFcfeplRMNSKIAGYHY------ 199
Cdd:cd14984   85 GILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEF-IFSQVSE-----ENGSSICSYDYpedtat 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 --------LRFTFGFAIPLGILAFTNHQIFRSIKLSDSlsaAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAA-SFSFY 270
Cdd:cd14984  159 twktllrlLQNILGFLLPLLVMLFCYSRIIRTLLRARN---HKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLqLLGII 235
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568980130 271 QGDmdavCAFESRLYTVSMVFLCLSTVNSVADPIIYV 307
Cdd:cd14984  236 SRS----CELSKSLDYALQVTESLAFSHCCLNPVLYA 268
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
46-306 9.14e-28

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 110.62  E-value: 9.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd14987    7 YIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIFSINLFG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP-VFDMKVEKS------FC--FEPLR-MNSKIA 195
Cdd:cd14987   87 SIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPdTYFLKTVTSpsnnetYCrsFYPEEsFKEWLI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 196 GYHYLRFTFGFAIPLGILAFTNHQIFRSIklsdSLSAAQKNKVKRSAIAV-VTIFLVCFAPYHVVLLVKAASFSFYqgdM 274
Cdd:cd14987  167 GMELVSIVLGFVIPFPIIAVFYFLLARAI----SASSDQERKSSRKIIFSyVVVFLVCWLPYHTVVLLDILSFLHL---I 239
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568980130 275 DAVCAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd14987  240 PFSCQLENFLYAALHVTQCFSLVHCCVNPILY 271
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
46-315 1.33e-27

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 110.23  E-value: 1.33e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWL--TLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNI 123
Cdd:cd15147    7 YSIIFVLGLIANCYVLWVfaRLYPSKKLNEIKIFMVNLTIADLLFLITLPFWIVYYHNEGNWILPKFLCNVAGCLFFINT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 124 YISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACV-ILLVGLVNYPVFD------MKVEKSF--CFEPLRMNSK- 193
Cdd:cd15147   87 YCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIwVIIVASASYFLFMdstntvKIDSGNFtrCFEGYEKDNSk 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 194 -IAGYHYLrFTFGFAIPLGILAFTNHQIFRSIkLSDSLSAAQKNKVKRSAI----AVVTIFLVCFAPYHVVLLVKAASFS 268
Cdd:cd15147  167 pVLIIHFI-IIGLFFLVFLLILVCNLVIARTL-LSQPVQGQRNAGVKRRALwmvcTVLAVFVICFVPHHVVQGPWTLAVL 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568980130 269 FYQGDMDavCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15147  245 QQWRYWD--CQFRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFRK 289
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
46-306 1.41e-27

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 109.84  E-value: 1.41e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15158    7 YSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYALYVNLYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPV-----FDMKVEKSFCFEPLRMNS---KIAGY 197
Cdd:cd15158   87 SIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFlmsgsHDTETNKTKCFEPPQSNQqltKLLVL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 HYLRFTFGFAIPLGILAFTNHQIFRSIkLSDSLSAAQKNKVKRSAI----AVVTIFLVCFAPYHVVLLVKAASFSFYqgd 273
Cdd:cd15158  167 NYISLVVGFIIPFLVILICYAMIIRTL-LKNTMKARKQQSSRKKAIrmiiIVLLAFLVSFMPYHIQRTIHLHFLSRK--- 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568980130 274 mDAVCAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15158  243 -DSTCEEVLYMQKSVVITLCLAAANCCFDPLLY 274
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
46-315 2.49e-27

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 109.42  E-value: 2.49e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIqNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15378    7 YSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSY-SNGQWLFGDFLCKSNRYLLHANLYS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMkveksfcfepLRMNSKIAGYHYLRFT-- 203
Cdd:cd15378   86 SILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTF----------IGPNLKDNVTKCKDYAss 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 204 ---------------FGFAIPLGILAFTNHQIFRSIKLSDSL--SAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAAS 266
Cdd:cd15378  156 gdatnsliyslfltvTGFLIPLCVMCFFYYKIALFLKNRNRQlaNATSFEKPLTLVILAVVIFSVLFTPYHVMRNVRIAS 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568980130 267 FSFYQGDMDAVCAFESRLYTVS--MVFLclstvNSVADPIIYVLGTDHSRQ 315
Cdd:cd15378  236 RLDSIGVSECTLIIIKSLYIVTrpIAFL-----NSVINPVFYFLMGDHFRE 281
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
46-306 2.73e-27

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 109.01  E-value: 2.73e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIyiQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15180    7 YSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAV--QAVHGWIFGTGLCKLAGAVFKINFYC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESrgHRHQRTAVTISACVI--LLVGLVNYPVF-------DMKVEKSFCFEPLRMNSKiAG 196
Cdd:cd15180   85 GIFLLACISFDRYLSIVHAVQM--YSRKKPMLVHLSCLIvwLFCLLLSIPDFifleatkDPRQNKTECVHNFPQSDT-YW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 YHYLRFTF---GFAIPLGILAFTNHQIFRsiKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAasfSFYQGD 273
Cdd:cd15180  162 WLALRLLYhivGFLLPLAVMVYCYTSILL--RLLRSSQGFQKQRAIRVIVAVVVVFFLCWTPYNIALLVDT---LIDLSV 236
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568980130 274 MDAVCAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15180  237 LDRNCGTESRLDIALSVTSSLGYFHCCLNPLLY 269
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
46-308 3.88e-27

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 108.73  E-value: 3.88e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVlqRNV-LAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15371    7 YIIVVVLGVPSNAIILWMLFFRL--RSVcTAIFYANLAISDLLFCITLPFKIVYHLNGNNWVFGETMCRIITITFYGNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSF-------CFEPLRMNSKIAGY 197
Cdd:cd15371   85 CSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFILKQTYYLkelnittCHDVLPECEQNSNF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 HYLRFT----FGFAIPLGILAFTNHQIFRSIKlsdSLSAAQKNKVKRSAIaVVTIFLVCFAPYHVVLLVKAASFSFYQGD 273
Cdd:cd15371  165 QFYYFIsmavFGFLIPLVITIFCYISIIRTLN---AYEHKWFWYVKITAL-VLIIFTICFAPSNVILIIHHFNYYYFNND 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568980130 274 MdavcafesrLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15371  241 N---------LYSIYLIALCLGSLNSCLDPFLYFL 266
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
46-315 4.46e-27

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 108.54  E-value: 4.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQvLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd14974    7 YALIFLLGLPGNGLVIWVAGFK-MKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVISLNMFA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSF-----CFEPLRM-----NSKIA 195
Cdd:cd14974   86 SVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHhngrsCNLTCVEdydlrRSRHK 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 196 GYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSdslSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVkaasfsfyqgdmD 275
Cdd:cd14974  166 ALTVIRFLCGFLLPLLIIAICYSVIAVKLRRK---RLAKSSKPLRVLLAVVVAFFLCWLPYHVFALL------------E 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568980130 276 AVCAFESRLYTVSMVFLCLST--VNSVADPIIYVLGTDHSRQ 315
Cdd:cd14974  231 LVAAAGLPEVVLLGLPLATGLayFNSCLNPILYVFMGQDFRK 272
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
46-317 5.82e-27

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 108.35  E-value: 5.82e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15370    7 YIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFFYGNMYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALeSRGHRHQRTAVTISACVILLVGLVNYPVF---------DMKVEKSFCFEPLRMNSKIAG 196
Cdd:cd15370   87 SILFMTCLSVQRYWVIVNPM-SHSRKKANIAIGISLAIWLLILLVTIPLYlvkqtvfipALDITTCHDVLPEQLLVGDMF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 YHYLRFTFG-FAIPLGILAFTNHQIFRSIK--LSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYqgd 273
Cdd:cd15370  166 NYFLSLAIGvFLFPAFLTAVAYVLMIRALKssINDESIEKKRKRAIKLIVTVLVMYLICFTPSNLLLVVHYFLLKNQ--- 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568980130 274 mdavcaFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15370  243 ------GQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFRDHV 280
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
46-308 7.42e-27

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 107.86  E-value: 7.42e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15148    7 YSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNNQWTLGPLLCKVVGNLFYMNMYI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYAleSRGHRHQRTAVTISACVIL----LVGLVNYPVFDMKVEKS-FCFE-PLRMNSKIAGYHY 199
Cdd:cd15148   87 SIILLGFISLDRYLKINRS--SRRQKFLTRKWSIVACGVLwavaLVGFVPMIVLTEKNEEStKCFQyKDRKNAKGKAIFN 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 LRFTFGFAIPLGILAFTNHQIFR-----SIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVkaasFSFYQGDm 274
Cdd:cd15148  165 FLIVAMFWLVFLLLILSYGKIAKkllriSRDKPDFPNAAKYNRTARKSFFVLFIFTVCFVPYHAFRIF----YITSQLQ- 239
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568980130 275 DAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15148  240 NNSCYWKEILHKTNEIMLLLSAFNSCLDPVMYFL 273
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
46-306 2.06e-26

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 106.67  E-value: 2.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15159    7 YSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGFDWPFGDWLCRLTALLFYINTYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKsfcfeplRMNSKIAGYHYLRF--- 202
Cdd:cd15159   87 GVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTK-------EMGGRITCMEYPNFeki 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 203 -----------TFGFAIPLGILAFT----NHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTI-FLVCFAPYHVVLLVKAAS 266
Cdd:cd15159  160 krlplillgacVIGFGVPVGIILFCysqiTLKLCRTAKENPLTEKSGHHKKACNVILLVLLvFVVCFSPYHLNIIQFMIR 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568980130 267 FSFYQGDMDAVCAFESRL-YTVsmvflCLSTVNSVADPIIY 306
Cdd:cd15159  240 KLLYQPSCSELKAFKISLqITV-----CLMNLNCCLDPFIY 275
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
46-311 2.82e-26

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 106.47  E-value: 2.82e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15156    7 FSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRN-WPFGDLLCKISVTLFYTNMYG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSF-------CFEplRMNSKIAGYH 198
Cdd:cd15156   86 SILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQlnnnsetCFE--NFSSKTWKTY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRF-----TFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQ--KNKVKRSAIAVVTIFLVCFAPYHVVLLVkaasFSFYQ 271
Cdd:cd15156  164 LSKIvifieIVGFFIPLILNVTCSTMVLKTLRRPNTLSRSKlnKKKVLKMIFVHLFIFCFCFIPYNVNLVL----YSLVR 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568980130 272 GDMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTD 311
Cdd:cd15156  240 TQTFKNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSE 279
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
48-317 2.98e-26

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 106.42  E-value: 2.98e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  48 AVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISI 127
Cdd:cd15380    9 AICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFGNFLCRVISGVIKANLFISI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 128 LLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSfcFEPLRMNSKI-----AGYHYLRF 202
Cdd:cd15380   89 FLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKH--VPDLNISACIllfphEAWHFARR 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 203 T----FGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSA-----IAVVTIFLVCFAPYHVVLLVKaasFSFYqgd 273
Cdd:cd15380  167 VelniVGFLLPLAAIVFFNFHIIASLRERTEESRKRCGGLKDTKatrliLTLVLMFLVCWTPYHFFAFLD---FLFQ--- 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568980130 274 MDAV--CAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15380  241 VEVIqgCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFRTKV 286
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
46-315 5.56e-26

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 105.45  E-value: 5.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQnQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd14970    7 YSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYL-LGYWPFGEVMCKIVLSVDAYNMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSF------CFEPLRMNSKIAGYHY 199
Cdd:cd14970   86 SIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEeggtisCNLQWPDPPDYWGRVF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 LRFTF--GFAIPLGILAFTNHQIFRSIKLSDSLSAA-------QKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAAsfsfy 270
Cdd:cd14970  166 TIYTFvlGFAVPLLVITVCYSLIIRRLRSSRNLSTSgarekrrARRKVTRLVLVVVAVFVVCWLPFHVFQIVRLL----- 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568980130 271 qGDMDavcafESRLYT-VSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd14970  241 -IDPP-----ETLTVVgVFLFCIALSYANSCLNPILYAFLDENFRK 280
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
51-306 1.52e-25

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 104.08  E-value: 1.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  51 LLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQhkWNLGPQACKVTAYIFFCNIYISILLL 130
Cdd:cd15923   12 VLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYRRE--SAGLQKLCNFVLSLYYINMYVSIFTI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 131 CCISCDRYMAVVYALESRGHRHQRTAVTISACVILLV--GLVNYPVFDMKVEKSFCFEplRMNSKIAGYHYLRF-TFGFA 207
Cdd:cd15923   90 TAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVvtISIPYFLLDSSNEKTMCFQ--RTKQTESLKVFLLLeIFGFL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 208 IPLGILAFTNHQIFRSI--KLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKaasfsfYQGDMDAVCAFESRLY 285
Cdd:cd15923  168 LPLIIMTFCSARVIHTLqkRLDDVGSRSETKQCIRVIMANLIVFIVCFLPVHVGFFVK------FIVGKSYSCDSKLIIH 241
                        250       260
                 ....*....|....*....|.
gi 568980130 286 TVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15923  242 FFLQSAFCLSDMNCCLDAFCY 262
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
46-314 1.71e-25

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 104.46  E-value: 1.71e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNqHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15154    7 YSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYAN-HYWPFGNFLCQFSGSIFQMNMYG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTA--VTISACVILLVGLVnyPVF---------DMKVEKSFCFEPLRMNSK- 193
Cdd:cd15154   86 SCLFLMCINVDRYLAIVHPLRFRHLRRPKVArlLCLAVWALILGGSV--PAAivhsssdclLHGEKVYRCFESFSDNDWk 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 194 -IAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVL----LVKAasfs 268
Cdd:cd15154  164 gLLPLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQGRRRKTVRLLLVNLVIFLICFVPYNTTLavygLLRA---- 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568980130 269 fyqGDMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSR 314
Cdd:cd15154  240 ---NLVEDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFR 282
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
46-308 1.29e-24

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 101.71  E-value: 1.29e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLqVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15114    7 YAVVFLVGVPGNALVAWVTGF-EAKRSVNAVWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLILLNMYA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRMnskiAGYHY------ 199
Cdd:cd15114   86 SVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEHFPEKTV----CVVDYggstgv 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 ------LRFTFGFAIPLGILAFTNHQIFRSIKlsdSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASfsfyqgd 273
Cdd:cd15114  162 ewavaiIRFLLGFLGPLVVIASCHGVLLVRTW---SRRRQKSRRTLKVVTAVVVGFFLCWTPYHVVGLIIAAS------- 231
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568980130 274 mDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15114  232 -APNSRLLANALKADPLTVSLAYINSCLNPIIYVV 265
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
46-307 3.78e-24

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 100.60  E-value: 3.78e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYiqNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15172    7 YSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVY--EAHQWIFGNFSCKLLRGIYAINFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRhQRT---------AVTISACVILLVGLVNYPVFDMKVEKSFC--------FEPL 188
Cdd:cd15172   85 GMLLLACISVDRYIAIVQATKSFRLR-SRTlaysklicaAVWLLAILISLPTFIFSEVYDFGLEEQYVcepkypknSTAI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 189 RMNSKIAGyhyLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLsaaQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFs 268
Cdd:cd15172  164 MWKLLVLS---LQVSLGFFIPLLVMIFCYSFIIKTLLQAQNS---QRHKAVRVVVAVVLVFLVCQVPYNIVLLIEAINL- 236
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568980130 269 fyqGDMDAvCAFESRLYTVSMVFLCLSTVNSVADPIIYV 307
Cdd:cd15172  237 ---GEQQS-CSSEKAVAYAKTITECLAFFHCCLNPVLYA 271
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
46-308 4.21e-24

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 100.60  E-value: 4.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15373    7 YGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLFYTNLYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF-----DMKVEKSFCFEPLRMN--SKIAGYH 198
Cdd:cd15373   87 SILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLyfvttSDKGGNITCHDTSSPElfDQFVVYS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFGFAIPLGILAFTNH-QIFRSIKLSDSLSAAQKNKVK--RSAIAVVTIFLVCFAPYHVvllvkAASFSFYQGDMD 275
Cdd:cd15373  167 SVMLVLLFCVPFVVILVCYAlMVRKLLKPSAGTSTNSRSKKKsvKMIIIVLAVFILCFLPFHV-----TRTLYYSFRSMD 241
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568980130 276 AVCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15373  242 LSCGTLNAINLAYKVTRPLASANSCLDPILYFL 274
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
46-312 7.57e-24

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 99.77  E-value: 7.57e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15967    7 YILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKGRKWIFGQVFCKITRFCFNLNLYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPvfDMKVEKSF-----CFEPlRMNSKIAGY--H 198
Cdd:cd15967   87 SIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLP--DLFFSKTNsngtkCFDT-TFNDYLESYltY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTF-GFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVvlLVKAASFSFYQGDMDAV 277
Cdd:cd15967  164 SLGWTVtGFVIPLLIILGCYGHVVVVLCRNNNVDKGLKQRCLKLVIILIVLFSVCYIPYHV--FRNLNLLSRILQKQGSC 241
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568980130 278 CAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDH 312
Cdd:cd15967  242 TQWFRGIYIAHQVSRGLVCLNSALNPLVYLMGSED 276
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
46-314 1.24e-23

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 99.11  E-value: 1.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15921    7 YILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVLYVNMYS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEK-----SFCFE-PLRMNSKIAGYHY 199
Cdd:cd15921   87 SIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQhdegsTRCLElAHDAVDKLLLINY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 LRFTFGFAIPLGILAFTNHQIFRS-IKLSDSLSAAQKNKVKRSAIAVVT--IFLVCFAPYHVVLLVkaasFSFYQGDMDA 276
Cdd:cd15921  167 VTLPVGFVVPFMTVIFCYIFIIKNlLKPSPALGRTRPSRRKACALIIISlgIFLVCFLPYHIVRTI----HLITERQIKE 242
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568980130 277 VCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSR 314
Cdd:cd15921  243 SCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFR 280
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
52-306 1.53e-23

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 98.56  E-value: 1.53e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  52 LGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQhkWNLGPQACKVTAYIFFCNIYISILLLC 131
Cdd:cd15165   13 LGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSSKKQ--WPLGRTLCSFLESLYFVNMYGSILIIV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 132 CISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF---DMKVEKSFCFEPLRMNSKIAGYHYLRFTFGFAI 208
Cdd:cd15165   91 CISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYsfhDKPTNNTRCFHGFSNKTWSKKVIVVVEEFGFLI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 209 PLGILAFTNHQIFRsiKLSDSLSAAQ----KNKVKRSAIAVVTIFLVCFAPYHVVLLVkaasFSFYQGDMDAVCAFESRL 284
Cdd:cd15165  171 PMAVMVFCSVQIIR--TLLDMRRPEQpkvkQNKSVKIVLSNLVVFLVCFTPYHLGIFL----QFLVKNDIINDCSTKQSI 244
                        250       260
                 ....*....|....*....|..
gi 568980130 285 YTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15165  245 RLFVQVSMCLANVNCCLDAICY 266
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
49-317 1.71e-23

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 98.69  E-value: 1.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  49 VCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISIL 128
Cdd:cd15189   10 LCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIKVNLYTSIY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 129 LLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSfcFEPLRMNSKIAGYHYLRFTF---- 204
Cdd:cd15189   90 LLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKA--IPDLNITACVLLYPHEAWHFahiv 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 205 -----GFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAI---AVVTIFLVCFAPYHVVLLVkaaSFSFYQGDMDA 276
Cdd:cd15189  168 llnivGFLLPLLVITFCNYNILQALRTREESTRCEDRNDSKATAlvlAVTLLFLVCWGPYHFFTFL---DFLFDVGVLDE 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568980130 277 vCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15189  245 -CFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRRKV 284
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
46-314 2.49e-23

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 98.29  E-value: 2.49e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15193    7 YLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAVNRCS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVtISACVILLVGLV-NYP--VFDMKVEKSFCFEPlRMNSKIAGYHYLRF 202
Cdd:cd15193   87 SILFLTGMSVDRYLAVVKLLDSRPLRTRRCAL-ITCCIIWAVSLVlGIPslVYRNLINESVCVED-SSSRFFQGISLATL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 203 TFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTI---FLVCFAPYHVvllVKAASFSFYQGDMDAVCA 279
Cdd:cd15193  165 FLTFVLPLIVILFCYCSILVRLRRHFHGAKRTGRRRRNSLRIVFAIvtaFVLSWLPFNT---LKAVRLLLELGGGVLPCH 241
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568980130 280 FESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSR 314
Cdd:cd15193  242 TTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFR 276
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
46-308 2.61e-23

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 97.92  E-value: 2.61e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQvLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15115    7 LSLTFLLGVPGNGLVIWVAGLK-MKRTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIVLNMFA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKveKSFcfepLRMNSKIAGYHYL----- 200
Cdd:cd15115   86 SVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYR--TTV----TDGNHTRCGYDFLvaiti 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 201 -RFTFGFAIPLGILAFTNHQIFRsiKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVkaasfSFYQGDmdavcA 279
Cdd:cd15115  160 tRAVFGFLLPLLIIAACYSFIAF--RMQRGRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGIL-----SLYGDP-----P 227
                        250       260
                 ....*....|....*....|....*....
gi 568980130 280 FESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15115  228 LSKVLMSWDHLSIALAYANSCLNPVLYVF 256
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
46-317 6.69e-23

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 97.18  E-value: 6.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15374    7 YGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLFYANLYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP-----VFDMKVEKSFCFEPLRMNSKIAGYHYL 200
Cdd:cd15374   87 SILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPnlifvTTSRKDNITLCHDTTRPEEFDHYVHYS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 201 RFTFG--FAIPLGILA-----FTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVvllvkAASFSFYQGD 273
Cdd:cd15374  167 SAVMVllFGIPCLVIVvcyglMARRLCKPRVGSSRQQGPSSKKRSLKTIIMVLTVFAICFVPFHI-----TRTLYYVARL 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568980130 274 MDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15374  242 LKADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRRRL 285
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
72-306 7.09e-23

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 96.56  E-value: 7.09e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  72 NVLAVYLFC---------------LSLCELLYISTVPLWIIYIQNQHKWNLgpqACKVTAYIFFCNIYISILLLCCISCD 136
Cdd:cd15164   18 NVLALWVFCckmkkwtetrvyminLAVADCCLLFSLPFVLYFLKHSWPDDE---LCLVLQSIYFINRYMSIYIITAIAVD 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 137 RYMAVVYALESRGHRHQRTAVTISACV-ILLVGLVNYPVFDMKVEKSFCFEPLrmnSKIAGYHYLRFT-FGFAIPLGILA 214
Cdd:cd15164   95 RYIAIKYPLKAKSLRSPRKAALTCGLLwVLVIISVSLRLAWEEQEENFCFGKT---STRPSKRTLIFSlLGFFIPLIILS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 215 FTNHQIFRSIKLSDSlSAAQKNKVKRSAIAVVT----IFLVCFAPYHVVLLVKaasfsFYQGDMDAVCAFESRLYTVSMV 290
Cdd:cd15164  172 FCSIQVIRSLKKKKK-TNPHEEKLIQKAIYIVSanliVFIVCFLPLHIGLLVR-----FVMESNKASCSLIQNIRNFIYV 245
                        250
                 ....*....|....*.
gi 568980130 291 FLCLSTVNSVADPIIY 306
Cdd:cd15164  246 ASCLANANCCLDAICY 261
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
46-315 1.49e-22

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 95.97  E-value: 1.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15191    7 YSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTLNLFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRtAVTISACVILLVGLVNYPVF---------DMKVEKSFCFEPLRMNSK-IA 195
Cdd:cd15191   87 SIFFITCMSVDRYLAVVYPLRSQRRRSWQ-ARLVCLLVWVLACLSSLPTFyfrdtyyieELGVNACIMAFPNEKYAQwSA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 196 GYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKN--KVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGD 273
Cdd:cd15191  166 GLALMKNTLGFLIPLIVIATCYFGIGRHLLKTKGFGKNKQRrdKVLKMVAAVVLAFLICWFPFHVLTFLDALARMGVINN 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568980130 274 MDAVCAFEsrlyTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15191  246 CWVITVID----KALPFAICLGFSNSCINPFLYCFVGNHFRE 283
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
46-316 1.97e-22

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 95.75  E-value: 1.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15203    7 YGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLcLVSLPFTLIYTLTKN-WPFGSILCKLVPSLQGVSIF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRghRHQRTAVTISACVILL-----------VGLVNYPVFDMKVEKSFCFE--PLRMN 191
Cdd:cd15203   86 VSTLTLTAIAIDRYQLIVYPTRPR--MSKRHALLIIALIWILslllslplaifQELSDVPIEILPYCGYFCTEswPSSSS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 192 SKIagYHYLRFTFGFAIPLGILAFTNHQIFRSIK--------LSDSLSAAQKNKVKRSA------IAVVTIFLVCFAPYH 257
Cdd:cd15203  164 RLI--YTISVLVLQFVIPLLIISFCYFRISLKLRkrvkkkrgKRTLSSRRRRSELRRKRrtnrllIAMVVVFAVCWLPLN 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 258 VVLLVKaasfsfyqgDMDAVCAFESRL-YTVSMVFLCLSTVNSVADPIIYVLGTDHSRQE 316
Cdd:cd15203  242 LFNLLR---------DFEPLPQIDGRHfYLIFLICHLIAMSSACVNPLLYGWLNDNFRKE 292
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
46-314 4.04e-22

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 94.83  E-value: 4.04e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd16001    7 YSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLFYTNLYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF-----DMKVEKSFCFEPLRMNSKIAGYHY- 199
Cdd:cd16001   87 SILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLvyartGSINNRTVCYDLTSPDNFGNYFPYg 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 --LRFTfGFAIPLGILAFTNHQIFRSIKLSDS---LSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVkaasFSFYQGDM 274
Cdd:cd16001  167 mvLTVT-GFLIPFLIILLCYCLMIKSLIRSEEaagVGKAARAKSIRTILLVCGLFALCFVPFHITRTI----YLFVRVYL 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568980130 275 DAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSR 314
Cdd:cd16001  242 VQDCPLLQFVSLAYKIWRPLVSFNSCINPLLYFLSGDSNR 281
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
46-308 5.11e-22

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 94.84  E-value: 5.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWII-YIQNQHkWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15968    7 YSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYnYAMRDR-WLFGDFMCRLVRFLFYFNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF-----DMKVEKSFCFE--PLRMNSKIAGY 197
Cdd:cd15968   86 GSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILifartGIIRNRTVCYDlaPPALFPHYVPY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 HYLRFTFGFAIPLGILAFTN----HQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGD 273
Cdd:cd15968  166 GMALTVSGFLLPFSIILWCYclvvRTLCRTLGPAEPPAQARRRKSIRTIVTVTLLFALCFLPFHITRTIYLAVRVTPGVP 245
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568980130 274 MDAVCAFeSRLYTVSMVflcLSTVNSVADPIIYVL 308
Cdd:cd15968  246 CHVLEAV-AACYKITRP---LASANSVLNPLLYFL 276
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
46-311 7.09e-22

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 94.06  E-value: 7.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQvLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15116    7 YSVVFVLGVLGNGLVIFITGFK-MKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNSFLLFLNMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMK-------VEKSFCF------------- 185
Cdd:cd15116   86 SVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRdtapsqnNNKIICFnnfslsgdnsspe 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 186 -EPLRmNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSdslSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVka 264
Cdd:cd15116  166 vNQLR-NMRHQVMTITRFLLGFLIPFTIIICCYAAIVLKLKRN---RLAKSSKPFKIIAAVIVTFFLCWAPYHILNLL-- 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568980130 265 asfsfyqgDMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYV-LGTD 311
Cdd:cd15116  240 --------EMEATRSPASVFKIGLPITSSLAFINSCLNPILYVfMGQD 279
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
49-308 7.18e-22

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 94.10  E-value: 7.18e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  49 VCLLGLPANCLTAWLTLLQvLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISIL 128
Cdd:cd15118   10 VSTLGIVENLLILWVVGFR-LRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFFLNMFVSGF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 129 LLCCISCDRYMAVVYALESRGHRHQRTA--VTISACVILLVGLVNYPVFDMKVE----KSFC------FEPLR------M 190
Cdd:cd15118   89 LLAAISLDRCLLVVKPVWAQNHRNVAAAkkICGVIWAMALINTIPYFVFRDVIErkdgRKLCyynfalFSPSPdnnhpiC 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 191 NSKIAGYHYLRFTFGFAIPLGILAFTNHQIfrsiklsdSLSAAQKNKVK-----RSAIAVVTIFLVCFAPYHVVLLVKAA 265
Cdd:cd15118  169 KQRQEGLAISKLLLAFLIPLVIIAVSYAVV--------SLIIRHRCRRRpgrfvRLVVSVVVSFALCWAPYHIFSIIEVM 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568980130 266 SfsfyqgdmDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15118  241 A--------HNQHSLRPLVIQGLPFATTLAFLNSVLNPVLYVF 275
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-306 1.03e-21

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 94.06  E-value: 1.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTL-LQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15190   17 YMLVFVLGLSGNGLVLWTVFrSKRKRRRSADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYLVFVNMY 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF-------DMKVEKSFCFEPLRM------- 190
Cdd:cd15190   97 ASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALilrttsdLEGTNKVICDMDYSGvvsnese 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 191 NSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRS----AIAVVTIFLVCFAPYHvvlLVKAAS 266
Cdd:cd15190  177 WAWIAGLGLSSTVLGFLLPFLIMLTCYFFIGRTVARHFSKLRRKEDKKKRRllkiIITLVVTFALCWLPFH---LVKTLY 253
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568980130 267 FSFYQGDMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15190  254 ALMYLGILPFSCGFDLFLMNAHPYATCLAYVNSCLNPFLY 293
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
51-307 1.08e-21

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 93.70  E-value: 1.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  51 LLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYISILLL 130
Cdd:cd14975   12 AIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGT-WDFGLAACKGCVYVCAVSMYASVFLI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 131 CCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF-----DMKVEKSFCFEPLRMNSKIAGYHYLRFTFG 205
Cdd:cd14975   91 TLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIafrhvEETVENGMCKYRHYSDGQLVFHLLLETVVG 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 206 FAIPLGILAFTNHQIFRSIKlsdSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSfyQGDMDAVCAFESRLY 285
Cdd:cd14975  171 FAVPFTAVVLCYSCLLRRLR---RRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSEL--IGGSKMAGTLGKVAE 245
                        250       260
                 ....*....|....*....|..
gi 568980130 286 TVSMVFLCLSTVNSVADPIIYV 307
Cdd:cd14975  246 AGRPIAGALAFLSSSINPLLYA 267
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
46-317 2.60e-21

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 92.45  E-value: 2.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15375    7 YSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINGESWIFGEFMCKFIRFIFHFNLYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALesRGHRHQRTAVTISACVILLVGLVN--YPVFDM-----KVEKSFC--FEPLRMNSKIAG 196
Cdd:cd15375   87 SILFLTCFSIFRYVVIVHPL--RAFQVQKRRWAIVACAVVWVISLAevSPMTFLittkeKNNRTICldFTSSDNLNTIWW 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 YHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKaasfsFYQGDMDA 276
Cdd:cd15375  165 YNWILTVLGFLLPLVIVTLCYTRIIYTLAKGPHTGSASKQKARRLIILILLVFYVCFLPFHILRVVR-----IETRLPPV 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568980130 277 VCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15375  240 SCCLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
46-317 1.16e-20

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 90.63  E-value: 1.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYiqnqHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15920    7 YSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRVAY----QNTAGPLSFCKIVGAFFYLNMYA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALES-RGHRHQ-RTAVTISACVILLVGLVnyPVFDMKVEKSFCFEP---LRMNSKIAGYHYL 200
Cdd:cd15920   83 SILFLSLISLDRYLKIIKPLQQfKIHTVPwSSAASGGVWLLLLACMI--PFLFESRNEGPCDNKcfhFRSKGLTAGGINL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 201 RFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKN-KVKRSAI----AVVTIFLVCFAPYHVVLLvkaaSFSFYQGDMD 275
Cdd:cd15920  161 TAVVIFYILSLLFLYFYAKISHKLYKVSLGNAQQQIkKASKRAIiktfIVLAIFIVCFVPYHIVRV----PYVLAQIDVI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568980130 276 AVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15920  237 SSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRRAV 278
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
46-317 1.25e-20

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 90.62  E-value: 1.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15153    7 YIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHT-WPFGRFLCLLCFYLKYLNMYA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRhQRTAVTISACVILLVGLVNYPVFDMKVEKSF-----CFEPLRMNSKIAGYHYL 200
Cdd:cd15153   86 SICFLTCISIQRCFFLLHPFKARDWK-RRYDVGISAAVWIVVGLACLPFPLLRSKSLSnnnrsCFADLGMKKLNFGAAIA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 201 RFT----FGFAIPLGILAFTNHQIFRSIKLSDSL--SAAQKNKVKRSAIAVVTIFLVCFAPYHVvllvkaaSFSFY---Q 271
Cdd:cd15153  165 MMTvaelFGFVIPLFIIAWCTWKTENSLRQRNKQqqSTSEKQKALRMVRMCAAVFFICFAPYHI-------NFLFYlmvS 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568980130 272 GDMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15153  238 ESIITNCEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQDQL 283
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
46-311 2.38e-20

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 90.18  E-value: 2.38e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQvLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15117    7 YSSAFVLGTLGNGLVIWVTGFR-MTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVFNLFA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF---DMKVE--KSFCF------------EPL 188
Cdd:cd15117   86 SVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLvfrDTRKEngCTHCYlnfdpwnetaedPVL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 189 RMNSKIAGYHYL---RFTFGFAIPLGILAFTNHQIfrSIKLSDSlSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAA 265
Cdd:cd15117  166 WLETVVQRLSAQvitRFVLGFLVPLVIIGGCYGLI--AARLWRE-GWVHSSRPFRVLTAVVAAFFLCWFPFHLVSLLELV 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568980130 266 SFSFYQGDMdavcafESRLYTVSMVFLCLSTVNSVADPIIYV-LGTD 311
Cdd:cd15117  243 VILNQKEDL------NPLLILLLPLSSSLACVNSCLNPLLYVfVGRD 283
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
46-315 2.50e-20

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 89.78  E-value: 2.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15152    7 YTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKS-WPFGKFLCMFCFYLKYVNMYA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRG-HRHQRTAVTISACVILLVGLVNYPVFDMKVEKSF--CFEPLRMNSKIAGYHYLRF 202
Cdd:cd15152   86 SIYFLVCISVRRCLYLIYPFRYNDcKRKCDVYISIAGWLVVCVGCLPFPLLRQSQDTNPtcCFADLPLRNVGLTTSVIML 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 203 T----FGFAIPLGILAFTNHQIFRSIKLSDSLS--AAQKNKVKRSAIAVVTIFLVCFAPYHVvllvkaaSFSFY---QGD 273
Cdd:cd15152  166 TiaelTGFVTPLLIVLYCSWKTVMSLREKTPVLqdLGEKKKALKMILTCAVVFLICFAPYHI-------SFPLDflvKSN 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568980130 274 MDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15152  239 KIKSCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKR 280
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
46-308 3.92e-20

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 89.05  E-value: 3.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15088    7 FGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALDANNQFT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF-DMKVEK-----SFCFEPLRMNSKIAGYHY 199
Cdd:cd15088   87 STYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWvYSSLIYfpdgtTFCYVSLPSPDDLYWFTI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 LRFTFGFAIPLGILAFTN----HQIFRSIKLSDSLSAAQKNK-VKRSAIAVVTIFLVCFAPYHVVLLVKAA----SFSFY 270
Cdd:cd15088  167 YHFILGFAVPLVVITVCYililHRLARGVAPGNQSHGSSRTKrVTKMVILIVVVFIVCWLPFHVVQLVNLAmnrpTLAFE 246
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568980130 271 QGdmdavcafesrlYTVSMvflCLSTVNSVADPIIYVL 308
Cdd:cd15088  247 VA------------YFLSI---CLGYANSCLNPFVYIL 269
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
46-307 6.11e-20

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 88.68  E-value: 6.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLtLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15151    7 YTVLFLVGLILNSVAAWI-FFHIPSTSTFIVYLKNTLVADLIMTLMLPFKILSDSGLGPWQLRAFVCRFSAVVFYITMYI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILL--------VGLVNYPVFDMKVEKSFCFE-PLRMNSKIAG 196
Cdd:cd15151   86 SIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVmfllsvpnMILSNKPATPISVKKCASLKsPLGLKWHEVV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 YHYLRFTF--GFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLvkaaSFSFYQGDM 274
Cdd:cd15151  166 NYICQFIFwgVFALMVLFYTIISKKVYESYKKSRSKDNKASKKTKAKVFIIVAVFFVCFAPFHFVRV----PYTLSQTGK 241
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568980130 275 DAVCAFESRLYTVSMVFLCLSTVNSVADPIIYV 307
Cdd:cd15151  242 ITDCQLQNLLYIAKEITLWLAATNVCLDPLIYI 274
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
46-315 6.51e-20

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 88.67  E-value: 6.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15093    7 YAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRH-WPFGSVLCRLVLSVDGINMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP--VFDMKVEKSFCFEPLRMN------SKIAGY 197
Cdd:cd15093   86 SIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPvvVFAGTRENQDGSSACNMQwpepaaAWSAGF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 HYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQK-----NKVKRSAIAVVTIFLVCFAPYHVVLLVkaasfsfyqg 272
Cdd:cd15093  166 IIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQrkrseRKVTRMVVMVVVVFVICWLPFYVLQLV---------- 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568980130 273 DMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15093  236 NVFVQLPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKK 278
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
46-308 7.32e-20

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 88.71  E-value: 7.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWL--TLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNI 123
Cdd:cd14976    7 YMVVFTVGLLGNLLVLYLlkSNKKLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKLNM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 124 YISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP--VFDMKVEKSFCFE--PLRMNSKIAG--- 196
Cdd:cd14976   87 YSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPeaIFSTDTWSSVNHTlcLLRFPKNSSVtrw 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 ------YHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAAsfsfy 270
Cdd:cd14976  167 ynwlgmYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSKRRKSRVTKSVFIVVLSFFICWLPNQALSLWSAL----- 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568980130 271 qGDMDAVcAFESRLYTVSMVFL----CLSTVNSVADPIIYVL 308
Cdd:cd14976  242 -IKFDDV-PFSDAFFAFQTYAFpvaiCLAHSNSCLNPVLYCL 281
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
46-306 8.16e-20

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 88.27  E-value: 8.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLtAWLTLLQVLQ-RNVLAVYLFCLSLCELLYISTVPLWIIyiQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15181    7 YSLVFLLGVVGNGL-VLTILLRRRRsRRTTENYLLHLALADLLLLLTFPFSVV--ESIAGWVFGTFLCKLVGAIHKLNFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP-VFDMKVEKSfcFEPLRM-----NSKIAGYH 198
Cdd:cd15181   84 CSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPnLVFLEVETS--TNANRTscsfhQYGIHESN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YL---RFTF---GFAIPLGILAFTNHQIFRSikLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASfsfYQG 272
Cdd:cd15181  162 WWltsRFLYhvvGFFLPLLIMGYCYATIVVT--LCQSSRRLQKQKAIRVAILVTLVFCLCWLPYNIVIFLDTLD---DLK 236
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568980130 273 DMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15181  237 AVVKNCKLNDLLDAAITVTESLGFSHCCLNPILY 270
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
46-307 1.41e-19

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 87.51  E-value: 1.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQhkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15175    7 YSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASAAKK--WVFGEEMCKAVYCLYKMSFFS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESrgHRHQRTAVTIS----ACVILLVGLVNYPvfDMKVEKSFCFEPLRMNSKIAGYHYLR 201
Cdd:cd15175   85 GMLLLMCISIDRYFAIVQAASA--HRHRSRAVFISkvssLGVWVLAFILSIP--ELLYSGVNNNDGNGTCSIFTNNKQTL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 202 FT--------FGFAIPLGILAFTNHQIFRSIKLSDSLsaaQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASfSFYQGD 273
Cdd:cd15175  161 SVkiqisqmvLGFLVPLVVMSFCYSVIIKTLLQARNF---EKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLS-SFKGNT 236
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568980130 274 MDavCAFESRLYTVSMVFLCLSTVNSVADPIIYV 307
Cdd:cd15175  237 TD--CDYSKNLDFALDVTYSLACFRCCLNPFLYA 268
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
33-308 3.28e-19

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 87.53  E-value: 3.28e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  33 VSYEESRVVLVVVYSAVCLLGLPANcLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQhKWNLGPQAC 112
Cdd:PHA03087  34 IGYDTNSTILIVVYSTIFFFGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILF-QWSFGEFAC 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 113 KVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKS-----FCFEP 187
Cdd:PHA03087 112 KIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKdhetlICCMF 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 188 LRMNSKI--AGYHYLRFTFGFAIPLGILAFTNHQIFrsIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAA 265
Cdd:PHA03087 192 YNNKTMNwkLFINFEINIIGMLIPLTILLYCYSKIL--ITLKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSL 269
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568980130 266 -SFSFYQGdmdavCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:PHA03087 270 hILHFKSG-----CKAVKYIQYALHVTEIISLSHCCINPLIYAF 308
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
46-308 3.35e-19

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 86.72  E-value: 3.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQvLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15119    7 YIVAFVLGVPGNAIVIWVTGFK-WKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAVLNMFA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF------DMKVEKSFCFEPLRMNSK--IAGY 197
Cdd:cd15119   86 SVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALyfrdtmELSINVTICFNNFHKHDGdlIVMR 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 H----YLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAaqkNKVKRSAIAVVTIFLVCFAPYHV--VLLVKAASFSFYQ 271
Cdd:cd15119  166 HtilvWVRFFFGFLFPLLTMVVCYSLLAIKVKRRTLLIS---SKFFWTISAVIVAFFVCWTPYHIfsILELSIHHSSYLH 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568980130 272 GDMDAVCAFESrlytvSMVFLclstvNSVADPIIYVL 308
Cdd:cd15119  243 NVLRAGIPLAT-----SLAFI-----NSCLNPILYVL 269
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
76-306 2.07e-18

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 84.44  E-value: 2.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  76 VYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRT 155
Cdd:cd15200   37 MYLLSLVVADFFLIINLPFRIDYYLRNEVWRFGATACQVNLFMLSMNRTASIVFLTAIALNRYLKVVHPHHQLSKASVGC 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 156 AVTISACVILLVGLVNYPVF--DMKVEKSFC--FEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLS 231
Cdd:cd15200  117 AAKVAAGLWILILLLNIHLLllDHVQSNSTClsYDHGTDPSASDRWHRILFFLEFFLPLGIILFCIFSIILTLKQRKLAK 196
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568980130 232 AAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDMDAVCAfesRLYTVSMVFLCLstvNSVADPIIY 306
Cdd:cd15200  197 QAGPQRAVKVLAVIVLVYTVCFLPSILFALASLVAFKVSQCRSLDLCT---QLFHGSLAFTYL---NSALDPVLY 265
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
46-306 2.40e-18

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 84.33  E-value: 2.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15392    7 YSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMaVFCVPFSFIALLILQYWPFGEFMCPVVNYLQAVSVF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQrtAVTISACVILLVGLVNYPV---------FDMKVEKSFCFE--PLRMNSK 193
Cdd:cd15392   87 VSAFTLVAISIDRYVAIMWPLRPRMTKRQ--ALLLIAVIWIFALATALPIaitsrlfedSNASCGQYICTEswPSDTNRY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 194 IagYHYLRFTFGFAIPLGILAFTNHQIFRSI----------KLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVk 263
Cdd:cd15392  165 I--YSLVLMILQYFVPLAVLVFTYTRIGIVVwakrtpgeaeNNRDQRMAESKRKLVKMMITVVAIFALCWLPLNILNLV- 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568980130 264 aasfsfyqGDMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15392  242 --------GDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIY 276
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
46-308 2.42e-18

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 84.06  E-value: 2.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLwiIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15177    7 YLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPF--AAAETLQGWIFGNAMCKLIQGLYAINFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVI--LLVGLVNYPVF-----DMKVEKSFC---FEPLRMNSKIA 195
Cdd:cd15177   85 GFLFLTCISVDRYVVIVRATSAHRLRPKTLFYSVLTSLIvwLLSILFALPQLiysrvENRSELSSCrmiFPEVVSRTVKG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 196 GYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSlsaAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSfyqGDMD 275
Cdd:cd15177  165 ATALTQVVLGFAIPLIVMAVCYAAIGRTLLAARG---WERHRALRVIAALVVAFVLFQLPYSVVLLLDTADLL---ATLE 238
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568980130 276 AVCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15177  239 LSCSQSKRKDIALLVTSGLAYVRCCLNPLLYAF 271
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
51-306 3.69e-18

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 83.46  E-value: 3.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  51 LLGLPANCLtAWLTLLQVLQRNVLAVYLFCLSL--CELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISIL 128
Cdd:cd15170   12 LIGLPANLL-AFYTFIRKVRRKPTPIDILLLNLtvSDLIFLLFLPFKMAEAASGMIWPLPYFLCPLSSFIFFSTIYISTL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 129 LLCCISCDRYMAVVYALESRGHRHQRTAVTISA---------C-VILLVGLVNYPVFDMKVEKSFCFE-----------P 187
Cdd:cd15170   91 FLTAISVERYLGVAFPIKYKLRRRPLYAVIASVffwvlafshCsIVYIVEYHIDSENTSVTNNSRCYDnftpeqlkillP 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 188 LRMnskiagyhyLRFTFGFAIPLGILAFTnhqIFRSIKLSDSLSAAQKNKvKRSAI--AVVT--IFLVCFAPY---HVVL 260
Cdd:cd15170  171 VRL---------ELFLVLFCIPFLITCFC---YINFIRILSSLPHISRQR-KQRAIglAVATllNFIVCFAPYnisHVVG 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568980130 261 LVKAASFSFyqgdmdavcafesRLYTvsmvfLCLSTVNSVADPIIY 306
Cdd:cd15170  238 FIQRKSPEW-------------RMYA-----LLLSTLNACLDPIIF 265
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
49-315 4.46e-18

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 83.50  E-value: 4.46e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  49 VCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISIL 128
Cdd:cd15096   10 IFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 129 LLCCISCDRYMAVVYALESRGHRHQRTAVtISACVILLVGLV-NYPVFDMKVEKSFCFEPL---------RMNSKIAGYH 198
Cdd:cd15096   90 TLVLMSLDRYLAVVHPITSMSIRTERNTL-IAIVGIWIVILVaNIPVLFLHGVVSYGFSSEaysyctfltEVGTAAQTFF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFGFAIPLGILAFTNHQIFR--------SIKLSDSlSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKaasfsFY 270
Cdd:cd15096  169 TSFFLFSYLIPLTLICVLYMLMLRrlrrqkspGGRRSAE-SQRGKRRVTRLVVVVVVVFAICWLPIHIILLLK-----YY 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568980130 271 QGDMdavcafESRLYTVSMV-FLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15096  243 GVLP------ETVLYVVIQIlSNCLAYGNSCVNPILYAFLSQNFRK 282
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
46-308 4.47e-18

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 83.65  E-value: 4.47e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLtLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15924    7 YTVIFFAGILLNGLAMWI-FFHIPSKSSFIIYLKNTVVADLLMILTFPFKILSDAGLGPWQLRTFVCRVTSVLFYFTMYT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVG--------LVNYPVFDMKVEK-SFCFEPLRMNSKIAG 196
Cdd:cd15924   86 SIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFllslpnmiLTNQQPREKNVKKcSFLKSELGLKWHEIV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 YHYLRFTFGFAIPLGILAFT--NHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLvkaaSFSFYQGDM 274
Cdd:cd15924  166 NYICQVIFWIVFLLMIVCYTaiTKKVYRSYRRVFRSSSSRRKKSNVKIFIIVAVFFVCFVPYHFARI----PYTLSQTRD 241
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568980130 275 DAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15924  242 VFDCTAENILFYVKEATLFLSALNVCLDPIIYFF 275
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
46-315 6.53e-18

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 82.90  E-value: 6.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd14971    7 FALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEK-------SFCFEPLRMNSKIAGYH 198
Cdd:cd14971   87 SIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRnytpgnrTVCSEAWPSRAHRRAFA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFGFAIPLGILAFTNHQIFRSI-KLSD-----SLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKA---ASFSF 269
Cdd:cd14971  167 LCTFLFGYLLPLLLICVCYAAMLRHLwRVAVrpvlsEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLVAlgpFPLTY 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568980130 270 YQgdmdavcafesrlYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd14971  247 AT-------------YALRIWAHCLAYSNSAVNPVLYAFLSEHFRK 279
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
46-308 7.43e-18

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 82.86  E-value: 7.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15192    7 YSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNLYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP-------VFDMKVEKSFC--FEPLRMNSKIAG 196
Cdd:cd15192   87 SVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPaiihrdvFFIENTNITVCafHYPSQNSTLLVG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 YHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSL--SAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAasfsFYQGDM 274
Cdd:cd15192  167 LGLMKNLLGFLIPFLIILTCYTLIGKALKKAYEIqrNKPRNDEIFKMIMAVVLFFFFCWIPHQIFTFLDV----LIQLKV 242
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568980130 275 DAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15192  243 IQDCHIADIVDTAMPFTICIAYFNSCLNPILYGF 276
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
46-307 8.57e-18

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 82.49  E-value: 8.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIyiQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15174    7 YWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWAT--AASSGWVFGTFLCKVVNSMYKINFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVI--LLVGLVNYPVFDMKVEK-----SFCF----EPLRMNSKI 194
Cdd:cd15174   85 CMLLLTCISVDRYIAIVQATKAHNSKNKRLLYSKLVCFFvwLLSTILSLPEILFSQSKeeesvTTCTmvypSNESNRFKV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 195 AGYhYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLsaaQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAasfsfyqGDM 274
Cdd:cd15174  165 AVL-ALKVTVGFFLPFVVMVICYTLIIHTLLQAKRF---QKHKALKVIIAVVTVFVLSQLPYNSILLIKT-------INA 233
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568980130 275 DAV----CAFESRLYTVSMVFLCLSTVNSVADPIIYV 307
Cdd:cd15174  234 YNItitdCATSQNLDIAGQVTQSIAFLHSCLNPFLYV 270
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
49-317 1.31e-17

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 82.30  E-value: 1.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  49 VCLLGLPANCLTAwLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLWII--YIQNQHKWNLGPQACKVTAYIFFCNI-- 123
Cdd:cd14978   10 ICIFGIIGNILNL-VVLTRKSMRSSTNVYLAALAVSDILVlLSALPLFLLpyIADYSSSFLSYFYAYFLPYIYPLANTfq 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 124 YISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPV-FDMKVEKSF------------CFEPLRM 190
Cdd:cd14978   89 TASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRfFEYEVVECEncnnnsyyyvipTLLRQNE 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 191 NSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSA-------------IAVVTIFLVCFAPYH 257
Cdd:cd14978  169 TYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRRRRLLSrsqrrerrttimlIAVVIVFLICNLPAG 248
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 258 VVLLVKAASFSFYQGDMdavcafesrLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd14978  249 ILNILEAIFGESFLSPI---------YQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
46-317 1.56e-17

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 81.94  E-value: 1.56e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLW-IIYIQNQhkWNLGPQACKVTAYIFFCNI 123
Cdd:cd15095    7 FAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFlVCCVPFTaALYATPS--WVFGDFMCKFVNYMMQVTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 124 YISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPV-FDMKVEKS-------FCFEPLRMNSKIA 195
Cdd:cd15095   85 QATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVaIYYRLEEGywygpqtYCREVWPSKAFQK 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 196 GYHYLRFTFGFAIPLGILAFTNHQIFRSI--------KLSDSLS---AAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKA 264
Cdd:cd15095  165 AYMIYTVLLTYVIPLAIIAVCYGLILRRLwrrsvdgnNQSEQLSeraLRQKRKVTRMVIVVVVLFAICWLPNHVLNLWQR 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568980130 265 ASFSFyqgdmdavcAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15095  245 FDPNF---------PETYATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
46-306 1.62e-17

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 81.74  E-value: 1.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIyiQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15179    7 YSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAV--DAAANWYFGNFLCKAVHVIYTVNLYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP--VFDMKVEKSFCFEPLRMNSK------IAGY 197
Cdd:cd15179   85 SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPdlVFAKVSELDDRYICDRIYPEdtfelwVVAF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 HYLRFTFGFAIPlGILAFTNHQIFRSiKLSDSlSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAAsfsFYQGDMDAV 277
Cdd:cd15179  165 RFQHILVGLVLP-GLVILTCYCIIIS-KLSHS-KGHQKRKALKTTVILILAFFACWLPYYIGISIDTF---MLLEIIKQS 238
                        250       260
                 ....*....|....*....|....*....
gi 568980130 278 CAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15179  239 CEMEQTVHKWISITEALAFFHCCLNPILY 267
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
46-306 1.67e-17

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 81.88  E-value: 1.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLyISTVPLWIIYIQNQHK-WNLGPQACKVTAYIFFCNIY 124
Cdd:cd14993    7 YVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLL-VSLFCMPLTLLENVYRpWVFGEVLCKAVPYLQGVSVS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTI------SACVILLVGLVNYPVFDMK------VEKSFCFE--PLRM 190
Cdd:cd14993   86 ASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIivaiwvIAIIIMLPLLVVYELEEIIssepgtITIYICTEdwPSPE 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 191 NSKIagYHYLRFTFGFAIPLGILAFTNHQIFRS-----------IKLSDSLSAAQKNKVK--RSAIAVVTIFLVCFAPYH 257
Cdd:cd14993  166 LRKA--YNVALFVVLYVLPLLIISVAYSLIGRRlwrrkppgdrgSANSTSSRRILRSKKKvaRMLIVVVVLFALSWLPYY 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568980130 258 VVLLVKaasfsfyqgDMDAVCAFESR--LYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd14993  244 VLSILL---------DFGPLSSEESDenFLLILPFAQLLGYSNSAINPIIY 285
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
46-312 1.84e-17

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 81.81  E-value: 1.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15971    7 YFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVH-WPFGKAICRVVMTVDGINQFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF-----DMKVEKSFC--FEPLRMNSKIAGYH 198
Cdd:cd15971   86 SIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMiyagvQTKHGRSSCtiIWPGESSAWYTGFI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFGFAIPLGILAFTNHQIFRSIKLS-----DSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGD 273
Cdd:cd15971  166 IYTFILGFFVPLTIICLCYLFIIIKVKSSgirvgSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVSISPTPG 245
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568980130 274 MDAVCAFesrlytvsmvFLCLSTVNSVADPIIYVLGTDH 312
Cdd:cd15971  246 LKGMFDF----------VVVLSYANSCANPILYAFLSDN 274
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
46-306 1.99e-17

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 81.58  E-value: 1.99e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWII-YIQNQhkWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15090    7 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVnYLMGT--WPFGNILCKIVISIDYYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSfcfEPLRMNSKIAGYH------ 198
Cdd:cd15090   85 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKY---RQGSIDCTLTFSHpswywe 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 ----YLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKN-----KVKRSAIAVVTIFLVCFAPYHVVLLVKAasfsf 269
Cdd:cd15090  162 nllkICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKA----- 236
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568980130 270 yqgdmdAVCAFESRLYTVSMVF-LCLSTVNSVADPIIY 306
Cdd:cd15090  237 ------LVTIPETTFQTVSWHFcIALGYTNSCLNPVLY 268
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
50-308 2.21e-17

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 81.38  E-value: 2.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  50 CLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILL 129
Cdd:cd15199   11 FGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFMLSLSRGVSIAF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 130 LCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSF----CFEPLRMNSKIAGYHYLRFTFG 205
Cdd:cd15199   91 LTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLLASQPKNFtecnSFSPKDDEDFSDTWQEAVFFLQ 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 206 FAIPLGILAFTNHQIFRSIKLSdSLSAAQKNKVKRS---AIAVVTIFLVCFAPyhvVLLVKAASFSFYQGDMDAVCAFES 282
Cdd:cd15199  171 FLLPFGLIVFCTVRIIRRLKKR-LRDVGKQPKLQRAmalVTSVVVVFGFCFLP---CFLARVLMLIFQNKESCNALNIAV 246
                        250       260
                 ....*....|....*....|....*.
gi 568980130 283 RLYTVSMvflCLSTVNSVADPIIYVL 308
Cdd:cd15199  247 HTYDVTM---CLTYLNSVLDPIVYCF 269
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
46-306 2.32e-17

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 81.44  E-value: 2.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15194    7 YCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIISVNMYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKV-----EKSFCFEPLRMNSKIAgYHYL 200
Cdd:cd15194   87 SVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRElkkyeEKEYCNEDAGTPSKVI-FSLV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 201 RFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRS---AIAVVTIFLVCFAPYHVVLLVKAASfsfyqGDMDAV 277
Cdd:cd15194  166 SLIVAFFLPLLSILTCYCTIIWKLCHHYQKSGKHQKKLRKSikiVFIVVAAFVFSWMPFNLFKALAIAS-----GLQVEV 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 568980130 278 CAFESRLYTVSM-VFLCLSTVNSVADPIIY 306
Cdd:cd15194  241 TCLPYTLAQLGMeVSAPLAFANSCANPFIY 270
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
46-267 3.21e-17

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 80.65  E-value: 3.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQhkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15186    7 YSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLINE--WGLHNAMCKLTTAFFFIGFFG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEK-SFCFE----------PLRMNSKI 194
Cdd:cd15186   85 GIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTKMKeNECLGdypevlqeiwPVLRNVEL 164
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568980130 195 AgyhylrfTFGFAIPLGILAFTnhqIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASF 267
Cdd:cd15186  165 N-------FLGFLLPLLIMSYC---YFRIIQTLFSCKNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETLKL 227
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
46-308 5.67e-17

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 80.32  E-value: 5.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLT-LLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15926    7 YSVVCALGLVGNLLVLYLMkSKQGWKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYVTAMNMY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP--VFDMKVEKS---FCFEPLRMNSKIAG--- 196
Cdd:cd15926   87 ASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPnaIFSTTATVSneeLCLVKFPDNRGNAQfwl 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 --YHYLRFTFGFAIPLGILAFTNHQIFRSI--KLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVV----LLVKAASFS 268
Cdd:cd15926  167 glYHAQKVLLGFLIPLGIISLCYLLLVRFItdKNITGSSTKRRSKVTKSVTIVVLSFFLCWLPNQALttwgILIKLNVVH 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568980130 269 FYQGdmdavcAFESRLYTVSmVFLCLSTVNSVADPIIYVL 308
Cdd:cd15926  247 FSYE------YFTTQVYIFP-ITVCLAHSNSCLNPILYCL 279
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
92-308 6.84e-17

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 79.53  E-value: 6.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  92 VPLWIIYiQNQHKWNLGPQACKV--TAYIFFCNIyiSILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGL 169
Cdd:cd14967   53 MPFSAVY-TLLGYWPFGPVLCRFwiALDVLCCTA--SILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLL 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 170 VNYPVF----DMKVEKSFCFEPLRMNSKIagYHYLRFTFGFAIPLGILAFTNHQIFRsiklsdslsAAQKN-KVKRSAIA 244
Cdd:cd14967  130 ISLPPLvgwrDETQPSVVDCECEFTPNKI--YVLVSSVISFFIPLLIMIVLYARIFR---------VARRElKAAKTLAI 198
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568980130 245 VVTIFLVCFAPYHVVLLVkaasfsfyqgdmDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd14967  199 IVGAFLLCWLPFFIIYLV------------SAFCPPDCVPPILYAVFFWLGYLNSALNPIIYAL 250
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
46-315 7.27e-17

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 79.90  E-value: 7.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15973    7 YALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQH-WPFGSAMCRTVLSVDGINMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRMN------SKIAGYHY 199
Cdd:cd15973   86 SVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACNliwphpAWSAAFVI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 LRFTFGFAIPLGILAFTNHQI---FRSIKLSDSLSAAQKN--KVKRSAIAVVTIFLVCFAPYHVVLLVkaasfSFYQGDM 274
Cdd:cd15973  166 YTFLLGFLLPVLAIGLCYILIigkMRAVALKAGWQQRRKSekKITRMVLMVVTVFVICWMPFYVVQLL-----NLFLPRL 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568980130 275 DAvcafesrlyTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15973  241 DA---------TVNHASLILSYANSCANPILYGFLSDNFRR 272
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
50-306 7.49e-17

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 79.80  E-value: 7.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  50 CLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILL 129
Cdd:cd14991   11 FVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLSVNRSASIAF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 130 LCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP-----VFDMKVEKSFC--FEPLRMNSKIAGYHYLRF 202
Cdd:cd14991   91 LTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPlllstLLTVNSNKSSChsFSSYTKPSLSIRWHNALF 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 203 TFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQK-NKVKRSAIAVVTIFLVCFAPyhVVLLVKAASFSFYQGDMDAVCAfe 281
Cdd:cd14991  171 LLEFFLPLGLIVFCSVRIACNLRIRQSLGKQARvQRAIRLVFLVVIVFVLCFLP--SIIAGLLALVFKNLGSCRCLNS-- 246
                        250       260
                 ....*....|....*....|....*
gi 568980130 282 srLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd14991  247 --VAQLFHISLAFTYLNSALDPVIY 269
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
49-317 7.54e-17

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 79.81  E-value: 7.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  49 VCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISIL 128
Cdd:cd15381   10 IFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMNLYSSIY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 129 LLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF---DMKVEKSFCFEPLRMNSKIAGYHY----LR 201
Cdd:cd15381   90 FLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIvfrTVMYFPEYNITACVLDYPSEGWHValniLL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 202 FTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSA---IAVVTIFLVCFAPYHVVLLVKaasfSFYQGDMDAVC 278
Cdd:cd15381  170 NVVGFLIPLSIITFCSTQIIQVLRNNKMQKFKEIQTERKATvlvLAVLLMFFICWLPFHIFTFLD----TLHKLGLISGC 245
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568980130 279 AFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15381  246 RWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRKKA 284
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
51-315 8.06e-17

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 79.86  E-value: 8.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  51 LLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQhKWNLGPQACKVTAYIFFCNIYISILLL 130
Cdd:cd15121   12 ILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGG-GWEFGSVVCKLCHYVCGVSMYASIFLI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 131 CCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPV------FDMKVEKSFCFePLRMNSKIAGYHYLRFTF 204
Cdd:cd15121   91 TLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMpfyrtvLKKNINMKLCI-PYHPSVGHEAFQYLFETI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 205 -GFAIPLGILAFTNHQIFRSIKlsdSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDMDAVCafeSR 283
Cdd:cd15121  170 tGFLLPFTAIVTCYSTIGRRLR---SARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQAGNASVL---KA 243
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568980130 284 LYTVSMVFLCLSTVNSVADPIIYVL-GTDHSRQ 315
Cdd:cd15121  244 AKLARPNVTALAFLSSSVNPVLYAFaGGSLIRS 276
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
46-306 9.11e-17

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 79.61  E-value: 9.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLW-IIYIQNQhkWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15091    7 YSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQsTVYLMNS--WPFGDVLCKIVISIDYYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDM---KVEKSFCFEPLRMNSKIAGYHYLR 201
Cdd:cd15091   85 TSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLggtKVREDVDSTECSLQFPDDDYSWWD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 202 -------FTFGFAIPLGILAFTNHQI---FRSIKLSDSLSAAQKN--KVKRSAIAVVTIFLVCFAPYHVVLLVKAAsfsf 269
Cdd:cd15091  165 tfmkicvFIFAFVIPVLIIIVCYTLMilrLKSVRLLSGSREKDRNlrRITRLVLVVVAVFVVCWTPIHIFILVEAL---- 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568980130 270 yqGDMDAVCAfesrlyTVSMVFLC--LSTVNSVADPIIY 306
Cdd:cd15091  241 --GSVSHSTA------AVSSYYFCiaLGYTNSSLNPILY 271
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
46-306 2.44e-16

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 78.45  E-value: 2.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWII-YIQNQhkWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15089    7 YSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAkYLMET--WPFGELLCKAVLSIDYYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSfcfepLRMNSKIAGYHYLR--- 201
Cdd:cd15089   85 TSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKT-----PRDGAVVCMLQFPSpsw 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 202 ----------FTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKN-----KVKRSAIAVVTIFLVCFAPYHVVLLVKAAS 266
Cdd:cd15089  160 ywdtvtkicvFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKEKdrnlrRITRMVLVVVAAFIICWTPIHIFVIVWTLV 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568980130 267 fsfyqgDMDavcafESRLYTVSMVFLC--LSTVNSVADPIIY 306
Cdd:cd15089  240 ------DID-----RRNPLVVAALHLCiaLGYANSSLNPVLY 270
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
46-270 2.91e-16

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 77.89  E-value: 2.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIyiQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15173    7 YSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAY--SAAHEWIFGTVMCKITNGLYTINLYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVI--LLVGLVNYPVFDMKV----EKSFCFEPLRMNSKIAGYHY 199
Cdd:cd15173   85 SMLILTCITVDRFIVIVQATKAHNCHAKKMRWGKVVCTLvwVISLLLSLPQFIYSEvrnlSSKICSMVYPPDAIEVVVNI 164
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568980130 200 LRFTFGFAIPLGILAFTNHQIfrsIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFY 270
Cdd:cd15173  165 IQMTVGFFLPLLAMIICYSVI---IKTLLHAKGFQKHKSLKIIFVVVAVFILTQLPYNIMKLIRTLHIENT 232
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
46-306 3.31e-16

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 77.89  E-value: 3.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd14988    7 YLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFYFANMYS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALES-RGHRHQRTAVT-----ISACVILLVGLVNYPVFDMKVEKSFCFEPLRMNSKIA-GYH 198
Cdd:cd14988   87 SIFFLTCLSVDRYLTLTSSSPFwQQHQHRIRRALcagiwVLSAIIPLPEVVHMQLLDGVEPMCLFLAPFETYDEWAlAVS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFGFAIPLGILAFTNHQIFRSIKlsdSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVkaasFSFYQGDMDAVC 278
Cdd:cd14988  167 LLTLIIGFLIPFSIIAVFNVLTARYIR---TAGRPESRRHCLLIYAYILVFVVCWLPYHVTLLL----LTLHGSHISLHC 239
                        250       260
                 ....*....|....*....|....*...
gi 568980130 279 AFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd14988  240 NLVHFLYFFYDVIDCFSLLHCVANPILY 267
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
46-315 3.33e-16

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 77.99  E-value: 3.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLtlLQVLQRNVLA---VYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCN 122
Cdd:cd15925    7 YGLVCAIGLLGNLAVMYL--LRNCARRAPPpidVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTATVLN 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 123 IYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRM-----NSKIAGY 197
Cdd:cd15925   85 VYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLlkfpsNYWLGAY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 HYLRFTFGFAIPLGILAFTNHQI--FRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVV----LLVKaasFSFYQ 271
Cdd:cd15925  165 HLQRVVVAFVVPLGVITTSYLLLlsFLQQHKVNQNNRQRQSVIARSVRLVVASFFLCWFPNHVVtfwgVLVK---FRAVP 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568980130 272 GDmDAVCAFESRLYTVSmvfLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15925  242 WN-STFYFIHTYVFPVT---TCLAHSNSCLNPVLYCLMRREFRQ 281
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
74-317 4.00e-16

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 77.84  E-value: 4.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  74 LAVYLFCLSLCELLYisTVPLWIiyiqnqhkwnLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQ 153
Cdd:cd15098   49 LFFLLFCVPFQATIY--SLPEWV----------FGAFMCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTR 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 154 RTAvTISACVILLVGL-------VNYPVF--DMKVEKSFCFEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTN----HQI 220
Cdd:cd15098  117 RNA-LLGVLVIWVLSLamaspvaVHQDLVhhWTASNQTFCWENWPEKQQKPVYVVCTFVFGYLLPLLLITFCYakvlNHL 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 221 FRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVV-LLVKAASFSFYQGDmdavcafesrlYTVSMVFLCLSTVNS 299
Cdd:cd15098  196 HKKLKNMSKKSERSKKKTAQTVLVVVVVFGISWLPHHIIhLWVEFGDFPLTQAS-----------FVLRITAHCLAYANS 264
                        250
                 ....*....|....*...
gi 568980130 300 VADPIIYVLGTDHSRQEV 317
Cdd:cd15098  265 CVNPIIYAFLSENFRKAY 282
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
46-315 4.86e-16

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 77.64  E-value: 4.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15970    7 YSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRH-WPFGSLLCRLVLSVDAINMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP--VFDMKVEKS----FC--FEPLRMNSKIAGY 197
Cdd:cd15970   86 SIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPiiIFSNTAPNSdgsvACnmQMPEPSQRWLAVF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 HYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIA-----VVTIFLVCFAPYHVVLLVkaasfSFYQG 272
Cdd:cd15970  166 VVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAGWQQRKRSERKITlmvmmVVTVFVICWMPFYVVQLV-----SVFVG 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568980130 273 DMDAvcafesrlyTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15970  241 QHDA---------TVSQLSVILGYANSCANPILYGFLSDNFKR 274
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
71-314 1.05e-15

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 76.70  E-value: 1.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  71 RNVLAVYLFCLSLCELLY-ISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRg 149
Cdd:cd14992   32 RGATNYFIASLAISDLLMaLFCTPFNFTYVVSLS-WEYGHFLCKIVNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPR- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 150 HRHQRTAVTISACVI----LLVGLVN--------YPVFDMKVEKSFCFEPLRMN-SKIAGYHYLRFTFGFAIPLGILAFT 216
Cdd:cd14992  110 HRQSYTTTVIIIITIwvvsLLLAIPQlyyattevLFSVKNQEKIFCCQIPPVDNkTYEKVYFLLIFVVIFVLPLIVMTLA 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 217 NHQIFR----------SIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQgdmdavcafESRLYT 286
Cdd:cd14992  190 YARISRelwfrkvpgfSIKEVERKRLKCKRRVIKMLVCVVVLFVICWLPFHLFFLLRDFFPLIMK---------EKHTLQ 260
                        250       260
                 ....*....|....*....|....*...
gi 568980130 287 VSMVFLCLSTVNSVADPIIYVLGTDHSR 314
Cdd:cd14992  261 VYYFLHWIAMSNSMYNPIIYVTLNNNFR 288
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
46-315 1.13e-15

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 76.38  E-value: 1.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLwiIYIQNQ-HKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15972    7 YLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPF--LAAQNAlSYWPFGSFMCRLVMTVDAINQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF---DMKVEKSFCF----EPLRMNSkiAGY 197
Cdd:cd15972   85 TSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVifsGVPGGMGTCHiawpEPAQVWR--AGF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 HYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRS-------AIAVVTIFLVCFAPYHVVLLVkaasfsfy 270
Cdd:cd15972  163 IIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRVRATSTKRRGSerkvtrmVVIVVAAFVLCWLPFYALNIV-------- 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 568980130 271 qgDMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15972  235 --NLVCPLPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQ 277
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
46-306 1.14e-15

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 76.38  E-value: 1.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQhkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15187    7 YCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLLDQ--WVFGNAMCKIVSGAYYIGFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP--VFDMKVE-----KSFCFEPLRMNSKIAGYH 198
Cdd:cd15187   85 SMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPllVFYQVASedgrlQCIPFYPGQGNSWKVFTN 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFGFAIPLGILAFTNHQIFRSIKlsdSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKaasfSFYQGDMDAVC 278
Cdd:cd15187  165 FEVNILGLLIPFSILIFCYHNILRNLR---RCHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLD----SLHSLHIIDGC 237
                        250       260
                 ....*....|....*....|....*...
gi 568980130 279 AFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15187  238 QNSQRLTLALHLTETISFTHCCLNPVIY 265
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
46-306 2.01e-15

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 75.63  E-value: 2.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQnQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15185    7 YSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVR-WNNWVFGHGMCKLLSGFYYLGLYS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF-----DMKVEKSFC--FEPLRMNSKIAGYH 198
Cdd:cd15185   86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFifyetQELFEEFLCspLYPEDTEDSWKRFH 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFT-FGFAIPLGILAFTNHQIFRSIKLSDSlsaAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDmdav 277
Cdd:cd15185  166 ALRMNiFGLALPLLIMVICYTGIIKTLLRCPS---KKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFFETD---- 238
                        250       260
                 ....*....|....*....|....*....
gi 568980130 278 CAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15185  239 CERSKHLDLAMQVTEVIAYTHCCINPVIY 267
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
46-264 2.46e-15

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 75.48  E-value: 2.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYiqNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15182    7 YYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASY--HSSGWIFGEILCKAVTSIFYIGFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACV------ILLVGLVNYPVFDMKVEKSFCfEPLRMNSKIaGYHY 199
Cdd:cd15182   85 SILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVwvisilASLPELILSTVMKSDEDGSLC-EYSSIKWKL-GYYY 162
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568980130 200 LRFTFgFAIPLGILAFTNHQIFRSIKLSDSLsaaQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKA 264
Cdd:cd15182  163 QQNLF-FLIPLGIIVYCYVRILQTLMRTRTM---RKHRTVKLIFVIVLVFFLSWAPYNIVIFLRS 223
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
46-306 3.55e-15

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 75.13  E-value: 3.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15157    7 YLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRIMSYSLYVNMYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEK----SFCFEP-LRMNSKIAGYHYL 200
Cdd:cd15157   87 SIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSPLLSKGTSKynsqTKCLDLhPSKIDKLLILNYI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 201 RFTFGFAIPLGILAFTNHQIFRSI---KLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDmdav 277
Cdd:cd15157  167 VLVVGFILPFCTLSICYILIIKALlkpRVPQSKLRVSHKKALLTIIITLILFLLCFLPYHILRTVHLMQWSEGQCN---- 242
                        250       260
                 ....*....|....*....|....*....
gi 568980130 278 cafeSRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15157  243 ----LRLHKAVVITLCLAAANSCLDPLLY 267
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
51-266 4.02e-15

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 74.84  E-value: 4.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  51 LLGLPANCLTAWLTL--LQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQhKWNLGPQACKVTAYIFFCNIYISIL 128
Cdd:cd15122   12 LLGLPGNGFIIWSILwkMKARGRSVTCILILNLAVADGAVLLLTPFFITFLTRK-TWPFGQAVCKAVYYLCCLSMYASIF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 129 LLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF-------DMKVEKSFCfEPLRMNSKIAGYHY-L 200
Cdd:cd15122   91 IIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFvyrhvwkDEGMNDRIC-EPCHASRGHAIFHYtF 169
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568980130 201 RFTFGFAIPLGILAFTNHQIFRSIKLSdslSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAAS 266
Cdd:cd15122  170 ETLVAFVLPFGVILFSYSVILVRLKGA---RFRRRARVEKLIAAIVVAFALLWVPYHVVNLLQVVA 232
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
46-315 4.46e-15

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 74.86  E-value: 4.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAwLTLLQVLQR--NVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNI 123
Cdd:cd15097    7 FSLIFLLGTVGNSLVL-AVLLRSGQSghNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 124 YISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFD----MKVEKSFCFEPLRMNSKIAGYHY 199
Cdd:cd15097   86 YASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSyydlIDYANSTVCMPGWEEARRKAMDT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 LRFTFGFAIPLGILAF----TNHQIFRSIKLSDSLSAAQ--KNKVKRSAIAVVTIFLVCFAPYHVVLLvkaasfSFYQGD 273
Cdd:cd15097  166 CTFAFGYLIPVLVVSLsytrTIKYLWTAVDPLEAMSESKraKRKVTKMIIIVTALFCLCWLPHHVVIL------CYLYGD 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568980130 274 MdavcAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15097  240 F----PFNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRK 277
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
46-306 4.67e-15

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 74.88  E-value: 4.67e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLtLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15149    7 YSLVFIVGILLNGVNFWI-FFYVPSNKSFIVYLKNIVFADLLMSLTFPFKILSDVELGPWQLNVIVCRYSAVIFYLNMYV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP---VFDMKVEKSFCFEPLRMNSKIA-----GY 197
Cdd:cd15149   86 GIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPniiLTNQSFHEANYTKCARLKSELGiqwhkAS 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 HYLRFTFGFAIPLGILAF---TNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLvkaaSFSFYQGDM 274
Cdd:cd15149  166 NYICVSIFWVVFLLLIIFyvaISRKIYKSNQKFRRNSTNMKAKSSRNIFSILFVFFVCFVPYHALRI----PYTLSQTGA 241
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568980130 275 DAVCAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15149  242 DYSCQSKTILYYMKEFTLLLSAANVCLDPIIY 273
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
46-315 8.50e-15

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 74.05  E-value: 8.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLwIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15094    7 YGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPF-LIVTMILKYWPFGAAMCKIYMVLTSINQFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF-----DMKVEKSFCFEPLRMNSKIAG---Y 197
Cdd:cd15094   86 SSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIIlyastVPDSGRYSCTIVWPDSSAVNGqkaF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 HYLRFTFGFAIPLG-ILAFTNHQIFR----SIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVvllvkaasFSFYQG 272
Cdd:cd15094  166 TLYTFLLGFAIPLLlISVFYTLVILRlrtvGPKNKSKEKRRSHRKVTRLVLTVISVYIICWLPYWA--------FQVHLI 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568980130 273 DMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15094  238 FLPPGTDMPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFRK 280
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
46-306 1.24e-14

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 73.75  E-value: 1.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANC---LTAWLTLlQVLQRNvlAVYLFCLSLCELLYISTVPLWII-YIQNQHkWNLGPQACKVTAYIFFC 121
Cdd:cd15379    7 YSVVFLLGLPLNAvviGQIWATR-QALSRT--TIYMLNLATADLLYVCSLPLLIYnYTQKDY-WPFGDFTCRLVRFQFYT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 122 NIYISILLLCCISCDRYMAVVYALESRGHRH-QRTAVTISACVILLVGLVNYPVF-----DMKVEKSFCFE--PLRMNSK 193
Cdd:cd15379   83 NLHGSILFLTCISVQRYLGICHPLASWHKKKgKKLTWLVCGAVWLVVIAQCLPTFvfastGTQRNRTVCYDlsPPARSTA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 194 IAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAA------QKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASF 267
Cdd:cd15379  163 YFPYGITLTRTGFLLPFAARLACYCSMATILCRVVIAVAVvaapgeKRGKAARMIIVVAAVFLISFLPFHYTKTRYLQVR 242
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568980130 268 SFYQGDMDAVCAFESRlYTVSMVFlclSTVNSVADPIIY 306
Cdd:cd15379  243 SWDGGPCTTRQAFAEA-YKRTRPF---ASMNSVLDPILF 277
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
57-306 1.54e-14

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 73.29  E-value: 1.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  57 NCLTAWLtLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCD 136
Cdd:cd15969   18 NGLAVWI-FFHIRNKTSFIFYLKNIVIADLLMTLTFPFKIIQDSGLGPWNFNFFLCRYTSVLFYASMYTSIVFLGLISLD 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 137 RYMAVVYALE-SRGHRHQRTAVtISACVILLVGLVNYPVFDMKVEksfcfEPLRMNskIAGYHYLRFTFG---------- 205
Cdd:cd15969   97 RYLKVVKPFGdSRMYSITFTKV-LSACVWLIMAFLSLPNIILTNG-----QPTEDN--IHDCSKLKSPLGvkwhtavsyi 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 206 ----FAIPLGILAFTNHQIFRSIKLSDS---LSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLvkaaSFSFYQGDMDAVC 278
Cdd:cd15969  169 niciFVAVLVILIVCYISISRYIYKSSKqfiSSSSRTRKHNQSIRVVVAVFFVCFLPYHLCRI----PFTFSQLDKILDC 244
                        250       260
                 ....*....|....*....|....*...
gi 568980130 279 AFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15969  245 TIKTILYYCKEATLFLSACNVCLDPIIY 272
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
46-262 1.62e-14

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 72.89  E-value: 1.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQ-RNVLAVYLFCLSLCELLYISTVPLWIIYIQNQhkWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15188    7 YTLVFLLGLAGNLLLFVVLLLYVPKkKKMTEVYLLNLAVSDLLFLVTLPFWAMYVAWH--WVFGSFLCKFVSTLYTINFY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRMNSKIAGYH-----Y 199
Cdd:cd15188   85 SGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNGVWVCHADYGGHHtiwklV 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568980130 200 LRFT---FGFAIPLGILAFTNHQIfrSIKLSDSLSAAQKNKVkRSAIAVVTIFLVCFAPYHVVLLV 262
Cdd:cd15188  165 FQFQqnlLGFLFPLLAMVFFYSRI--ACVLTRLRPPGQGRAL-RFVAALVVVFFVLWFPYNLTLFL 227
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
46-316 1.96e-14

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 73.19  E-value: 1.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15208    7 YILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRG-HRHQRTAVT---ISACVILLVGLVNYPVFDMKVEK------SFCFEPLRMNSKIA 195
Cdd:cd15208   87 SVLTLSCIALDRWYAICHPLMFKStAKRARVSILiiwIVSLLIMIPQAIVMECSRVVPLAnktillTVCDERWSDSIYQK 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 196 GYHYLRFTFGFAIPLGILAFTNHQIFRSI-----------------KLSDSLSAAQKN------KVKRSAIAVVTIFLVC 252
Cdd:cd15208  167 VYHICFFLVTYLLPLCLMILAYFQIFRKLwcrqipgtssvvqrkwnKPRKSAVAAEEKqlrsrrKTAKMLIVVVIMFAIC 246
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568980130 253 FAPYHVVLLVKAAsFSFYQGDMDAVCAFesrlYTVSMVflcLSTVNSVADPIIYVLGTDHSRQE 316
Cdd:cd15208  247 YLPVHLLNILRYV-FGLFTVDRETIYAW----FLFSHW---LVYANSAINPIIYNFMSGKFREE 302
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
46-306 3.10e-14

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 72.33  E-value: 3.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYIS--TVPLWIiYIQNQHkWNLGPQACKVTAYIFFCNI 123
Cdd:cd15390    7 FVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAfnTVFNFT-YLLYND-WPFGLFYCKFSNFVAITTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 124 YISILLLCCISCDRYMAVVYALEsrgHRHQRTAVTISACVILLVGLV------------NYPVFDMKV-EKSFCFEPLRM 190
Cdd:cd15390   85 AASVFTLMAISIDRYIAIVHPLR---PRLSRRTTKIAIAVIWLASFLlalpqllystteTYYYYTGSErTVCFIAWPDGP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 191 NSK-IAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSL---------SAAQKNKVKRSAIAVVTIFLVCFAPYHVVL 260
Cdd:cd15390  162 NSLqDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIgentprqleSVRAKRKVVKMMIVVVVIFAICWLPYHLYF 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568980130 261 LVKAASFSFYQgdmdavcafESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15390  242 ILTYLYPDINS---------WKYIQQIYLAIYWLAMSNSMYNPIIY 278
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
46-306 4.13e-14

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 71.82  E-value: 4.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15092    7 YLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGF-WPFGNALCKTVIAIDYYNMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF-----DMKVEKSFCFEPLRMNSKIAG--YH 198
Cdd:cd15092   86 STFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMvmgsaQVEDEEIECLVEIPTPQDYWDpvFG 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKN-----KVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSfyqgd 273
Cdd:cd15092  166 ICVFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSKEKdrnlrRITRLVLVVVAVFVGCWTPIQIFVLAQGLGVQ----- 240
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568980130 274 mdavcaFESRLYTVSMVF-LCLSTVNSVADPIIY 306
Cdd:cd15092  241 ------PSSETAVAILRFcTALGYVNSSLNPVLY 268
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
46-306 5.29e-14

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 71.54  E-value: 5.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYIST-VPLwIIYIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15001    6 YVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFcVPL-KTAEYFSPTWSLGAFLCKAVAYLQLLSFI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRG----HRHQRTAV-------TISACVILLVGLVNYPvFDMKVEKSFCFEPLRMNSK 193
Cdd:cd15001   85 CSVLTLTAISIERYYVILHPMKAKSfctiGRARKVALliwilsaILASPVLFGQGLVRYE-SENGVTVYHCQKAWPSTLY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 194 IAGYHYLRFTFGFAIPLGILAFtnhqifrsiklsdSLSAAQKNKVKRSAIAVVTIFLVCFAP---YHVVLLVKAASFSFY 270
Cdd:cd15001  164 SRLYVVYLAIVIFFIPLIVMTF-------------AYARDTRKQVIKMLISVVVLFAVCWGPlliDNLLVSFDVISTLHT 230
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568980130 271 QgdmdavcafesRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15001  231 Q-----------ALKYMRIAFHLLSYANSCINPIIY 255
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-315 1.07e-13

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 70.55  E-value: 1.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  47 SAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPlWIIYIQNQHKWNLGPQACKVTAYIFFCNIYIS 126
Cdd:cd14999    7 SLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIP-FYVSTYFLKKWYFGDVGCRLLFSLDFLTMHAS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 127 ILLLCCISCDRYMAVVYALESrGHRHQRTAVTISACVILLVGLVNYPVFDM----------KVEKSFCFEPLRMNSKIAg 196
Cdd:cd14999   86 IFTLTVMSTERYLAVVKPLDT-VKRSKSYRKLLAGVIWLLSLLLTLPMAIMirlvtvedksGGSKRICLPTWSEESYKV- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 YHYLRFTFGFAIPLGILAFTNHQIFRSIKLS------DSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFY 270
Cdd:cd14999  164 YLTLLFSTSIVIPGLVIGYLYIRLARKYWLSqaaasnSSRKRLPKQKVLKMIFTIVLVFWACFLPFWIWQLLYLYSPSLS 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 568980130 271 QGDMDAVCafesrlytVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd14999  244 LSPRTTTY--------VNYLLTCLTYSNSCINPFLYTLLTKNYKE 280
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
46-308 1.19e-13

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 70.67  E-value: 1.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQnQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15183    7 YSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKL-KDDWIFGDAMCKFLSGFYYLGLYS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP-VFDMKVEKSFCFEPLRMN-SKIAGYHYLRFT 203
Cdd:cd15183   86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPcLYFFKSQWEFTHHTCSAHfPRKSLIRWKRFQ 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 204 ------FGFAIPLGILAFTNHQIfrsIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDmdav 277
Cdd:cd15183  166 alklnlLGLILPLLVMIICYTGI---INILLRRPNEKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTPS---- 238
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568980130 278 CAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15183  239 CEQSQQLDLALQVTEVIAYTHCCVNPVIYVF 269
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
46-308 2.08e-13

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 69.77  E-value: 2.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIyiQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15176    7 YTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAA--DAVNGWVLGTAMCKITSALYTMNFSC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVvyaleSRGHRHQRTAV---TISACVILLVGLVNYP--VFDM---KVEKSFC---FEPLRMNSKI 194
Cdd:cd15176   85 GMQFLACISVDRYVAI-----TKATSRQFTGKhcwIVCLCVWLLAILLSIPdlVFSTvreNSDRYRClpvFPPSLVTSAK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 195 AGYHYLRFTFGFAIPLGILAFTNHQIFRSIKlsdSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASfSFYQGDM 274
Cdd:cd15176  160 ATIQILEVLLGFVLPFLVMVFCYSRVARALS---RTPNVKKSRALKVLLAVVGVFIVTQLPYNVVKFYRAID-VIYLLIT 235
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568980130 275 DavCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15176  236 D--CSMSKTLDIAIQVTESIALFHSCLNPVLYVF 267
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
46-308 2.49e-13

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 69.54  E-value: 2.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYI-FFCNIy 124
Cdd:cd14969    7 LSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAvTFLGL- 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVIL--------LVGLVNYpvfdmKVEKSFCFEPLRMNSKIAG 196
Cdd:cd14969   86 VSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWLYglfwalppLFGWSSY-----VPEGGGTSCSVDWYSKDPN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 ---YHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKN------------KVKRSAIAVVTIFLVCFAPYHVVLL 261
Cdd:cd14969  161 slsYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNsaitkrtkkaekKVAKMVLVMIVAFLIAWTPYAVVSL 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568980130 262 vkaasFSFYQGDMDavcaFESRLYTVSMVFLCLSTvnsVADPIIYVL 308
Cdd:cd14969  241 -----YVSFGGEST----IPPLLATIPALFAKSST---IYNPIIYVF 275
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
46-315 2.97e-13

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 69.44  E-value: 2.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLwiIYIQNQHK-WNLGPQACKVTAYIFFCNIY 124
Cdd:cd15974    7 YLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPF--LATQNAISyWPFGSFLCRLVMTVDGVNQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF---DMKVEKSFCF----EPLRMNSkiAGY 197
Cdd:cd15974   85 TSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIifsDVQPDLNTCNiswpEPVSVWS--TAF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 HYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQK-----NKVKRSAIAVVTIFLVCFAPYHVVLLVkaasfsfyqg 272
Cdd:cd15974  163 IIYTAVLGFFGPLLVICLCYLLIVIKVKSSGLRVGSTKrrkseRKVTRMVVIIVVVFVFCWLPFYMLNIV---------- 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568980130 273 DMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15974  233 NLIVILPEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQ 275
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
48-306 3.89e-13

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 68.92  E-value: 3.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  48 AVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISI 127
Cdd:cd15201    9 LEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTDYYLRGKHWKFGDIPCRIVLFMLAMNRAGSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 128 LLLCCISCDRYMAVVyalesrgHRHQR-TAVTISACVILLVGL----VNYPVFDMKVEKSFCFEPL---------RMNSK 193
Cdd:cd15201   89 FFLTAVAVDRYFRVV-------HPHHRiNSISVRKAAIIACGLwlltIAMTVYLLTKKHLFPRGNAtqcesfnicTGTDS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 194 IAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKlsdSLSAAQKNKVKRSA---IAVVTIFLVCFAPYHVVLLVKAASFSFY 270
Cdd:cd15201  162 SSNWHEAMFLLEFFLPLAIILYCSVRIIWQLR---GRQLDRHAKIKRAVqfiMVVAIVFIICFLPSNVTRIAIWILKHTS 238
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568980130 271 QGDmdavCAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15201  239 NED----CQYYRSVDLAFYITISFTYFNSMLDPVVY 270
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
46-308 5.54e-13

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 69.06  E-value: 5.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYI----FFC 121
Cdd:cd14996    7 YSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRIANFFgtlvIHV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 122 NIYISILLLCCISCDRYMAVVYALESR-----------GH-----RHQRTAVTISACVILLVGLVNYPV-------FDMK 178
Cdd:cd14996   87 SMCVSILILSWIAISRYATLMKHDSATqkqscyekifyGHflkrfRQPKFARYLCIYIWGVVLCIIIPVvvyysvrEADE 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 179 VEKSFCF----EPLRMNSKIAGYHYLRFTFGFAIP--LGILAFTNHqiFRSIKLSDSLSAAQK--NKVKRSAIAVVTIFL 250
Cdd:cd14996  167 DGESLCYnrqvELGAKGSQIAGLIATTFFFLFFLVvlLSYYSFVNH--LRRIQKNTCISEKDLiyRSVKRNILIIQALLV 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568980130 251 VCFAPYHVVLLVkaasfsFYQGDMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd14996  245 VCFLPYHIFKPV------FYVLHQREDCQQLNYLIETKNILTCLASARSSTDPIMYLL 296
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
47-315 1.21e-12

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 67.81  E-value: 1.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  47 SAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYIS 126
Cdd:cd15922    8 SLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLIAYFSLGSHWPFGQFLCQLKVFLLSTHMYGS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 127 ILLLCCISCDRYMAVVYaLESRGHRHQRTAVT-ISACVILLVGLVNYPVFdmkveksFCFEPLRMNSKIA---------- 195
Cdd:cd15922   88 IYFLMLISIHRYVTVVH-YNWKSLWKKKSFMKkLCLGVWLLLFVQGLPFF-------FVLKTSVIDGKTKclsihqsels 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 196 ----GYHYLRFTFGFAIPLGILAFTNHQIFRSI-KLSDSLSAAQKNKVKR-SAIAV-VTIFLVCFAPYHVVLLVKAASFS 268
Cdd:cd15922  160 llyfVWNFVLLILGFLLPFGVSLTCYALLGASIaKMNSNNARGRAMKAKSlQMIGIsLVIFIICFVPLHVTRTVGVVVKL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568980130 269 FYqgdmDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15922  240 FY----PESCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRK 282
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
71-306 1.69e-12

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 66.61  E-value: 1.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  71 RNVLAVYLFCLSLCELLY-ISTVPLWIIyIQNQHKWNLGPQACK--VTAYIFFCNIyiSILLLCCISCDRYMAVVYALES 147
Cdd:cd15061   31 RTITNCYIVSLATADLLVgVLVLPLAII-RQLLGYWPLGSHLCDfwISLDVLLCTA--SILNLCCISLDRYFAITYPLKY 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 148 RGHRHQRTAVTISACVILLVGLVNYPVF-----DMKVEKSFCFepLRMNskiAGYHYLRFTFGFAIPLGILAFTNHQIFR 222
Cdd:cd15061  108 RTKRSRRLAITMILAVWVISLLITSPPLvgpswHGRRGLGSCY--YTYD---KGYRIYSSMGSFFLPLLLMLFVYLRIFR 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 223 SIklsdslsaAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAA-SFSFYQgdmdavcafesrlyTVSMVFLCLSTVNSVA 301
Cdd:cd15061  183 VI--------AKERKTAKTLAIVVGCFIVCWLPFFIMYLIEPFcDCQFSE--------------ALSTAFTWLGYFNSVI 240

                 ....*
gi 568980130 302 DPIIY 306
Cdd:cd15061  241 NPFIY 245
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
51-258 2.84e-12

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 66.34  E-value: 2.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  51 LLGLPANCLTAWLTLLQvLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLL 130
Cdd:cd15120   12 LVGLVVNGLYLWVLGFK-MRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLSVGMFTSVFLL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 131 CCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF------DMKVEKSFCFEPLRMNSKIAGYHY----- 199
Cdd:cd15120   91 TAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLafretrLDEKGKTICQNNYALSTNWESAEVqasrq 170
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568980130 200 --------LRFTFGFAIPLGILAFTNHQIFRSIKlSDSLSAAQKnKVKRSAIAVVTiFLVCFAPYHV 258
Cdd:cd15120  171 wihvamfvFRFLLGFLLPFLIITFCYVRMALKMK-ERGLARSSK-PFKVMFTAVVS-FFVCWLPYHL 234
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
46-306 2.99e-12

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 66.32  E-value: 2.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15167    7 YYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAVDLGIAPWKLKIFHCQVTACLIYINMYL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYAleSRGHRHQRT--AVTISACVILLVGLVNYPVFDMKV----EKSF--CFEplrMNSKIA-G 196
Cdd:cd15167   87 SIIFLGFVSIDRYLQLTHS--SKLYRIQEPgfAKMISAVVWTLVLFIMVPNMAIPIktieEKPGvgCAD---FKTEFGrH 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 YHYLRFTFGFAIPLG----ILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLvkaaSFSFYQG 272
Cdd:cd15167  162 WHVLTNFICMAIFLNfsaiILISNFLVIRKLYRNKDSEEYRNARQALVNILLVTAGYVICFVPYHIVRI----PYTLSQS 237
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568980130 273 DMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15167  238 EVITDCSLKRSLFLAKESTLLLAVLNLCFDPILY 271
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
46-263 4.96e-12

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 65.99  E-value: 4.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQV---LQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCN 122
Cdd:cd15338    7 FGVICFLGIIGNSIVIYTIVKKSkfrCQQTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLITALDTNS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 123 IYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFD----MKVEKSFCFEPLRM---NSKIA 195
Cdd:cd15338   87 QITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMyaglMPLPDGSVGCALLLpnpETDTY 166
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568980130 196 GYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQK-----NKVKRSAIAVVTIFLVCFAPYHVVLLVK 263
Cdd:cd15338  167 WFTLYQFFLAFALPLVVICVVYFKILQNMASTVAPLPQRSlrvrtKKVTRMAVAICLAFFICWAPFYILQLAH 239
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
46-259 5.05e-12

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 65.53  E-value: 5.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNV-LAVYLFCLSLCELLYISTVPLWIIYIQnQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd14983    7 YVLTILLGLPSNLLALYAFVNRARLRLTpNVIYMINLCLSDLVFILSLPIKIVEAL-SSAWTLPAVLCPLYNLAHFSTLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRMNSKIAGYHY----- 199
Cdd:cd14983   86 ASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVIFHVTLVFILETSGGTLDINTPVGNSSTCYENftpeq 165
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568980130 200 ------LRFTFG---FAIPLGILAFTNHQIFRsIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPY---HVV 259
Cdd:cd14983  166 lallapVRLELSlvlFFLPLAITAFCYVRCIR-ILVRSRLHERRKRRAVRVAVSTLLTFVVCFGPYnisHVV 236
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
46-316 6.49e-12

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 65.60  E-value: 6.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLWIIYIQNQhKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15202    7 YSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMItLFNTPFTFVRAVNN-TWIFGLFMCHFSNFAQYCSVH 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESrghRHQRTAVTISACVILLVGL-----------VNYPVFDMKVEKSFCFE--PLRMN 191
Cdd:cd15202   86 VSAYTLTAIAVDRYQAIMHPLKP---RISKTKAKFIIAVIWTLALafalphaicskLETFKYSEDIVRSLCLEdwPERAD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 192 SKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQ----------KNKVKRSAIAVVTIFLVCFAPYHVVLL 261
Cdd:cd15202  163 LFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGDATteryfalrrkKKKVIKMLMVVVVLFALCWLPFNIYVL 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568980130 262 VKaASFSFYQGDMdavcafesrLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQE 316
Cdd:cd15202  243 LL-SSKPDYLIKT---------INAVYFAFHWLAMSSTCYNPFIYCWLNERFRIE 287
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
46-336 1.75e-11

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 65.03  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLqRNVLAVYLFCLSLCELLYISTVPlWIIYiQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:PHA02638 105 YIIIFILGLFGNAAIIMILFCKKI-KTITDIYIFNLAISDLIFVIDFP-FIIY-NEFDQWIFGDFMCKVISASYYIGFFS 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRMNSKIAGYH------- 198
Cdd:PHA02638 182 NMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFIFEASNIIFSAQDSNETISNYQctliedn 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 ----------YLRF---TFGFAIPLGILAFTNHQIFRSIKlsdSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAA 265
Cdd:PHA02638 262 eknnisflgrILQFeinILGMFIPIIIFAFCYIKIILKLK---QLKKSKKTKSIIIVSIIIICSLICWIPLNIVILFATM 338
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568980130 266 -SF-SFYQGDMDAVCAFESRLYTVsMVFLCLSTVNSVADPIIYVLGTDHSRQEV----SRIHTGWKKWSTKTYVTCS 336
Cdd:PHA02638 339 ySFkGFNSIISEHICGFIKLGYAM-MLAEAISLTHCCINPLIYTLIGENFRMHLlmifRNIFTNAKFSFRKSSISSS 414
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
46-306 2.45e-11

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 63.68  E-value: 2.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLtLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15150    7 YTVLFIVGLTMNGLAMRV-FFQIPSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGSWPLRGFVCQVTSVIFYFTMYI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALES------RGHRHQRTAVTISACVILL--VGLVNYPVFDMKVEKSFCFEP---LRMNSKI 194
Cdd:cd15150   86 SILFLGLITIDRYQKTTRPFKTsnpknlLGAKILSTVIWASMFALSLpnMILTNRQPTPKNVKKCSLLKSefgLVWHEIV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 195 AGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLvkaaSFSFYQGDM 274
Cdd:cd15150  166 NYICQVIFWVNFLIVIVCYTLITKELYKSYKRTRGVGKVSRKKVNVKVFIIIAVFFICFVPFHFARI----PYTLSQTRD 241
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568980130 275 DAVCAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15150  242 VFDCTAKNTLFYVKESTLWLTSLNACLDPFIY 273
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
46-308 3.07e-11

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 63.46  E-value: 3.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYI------STVPLWIIYIqnqhkWNLGPQACKVTAYIF 119
Cdd:cd14997    7 YGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLlvcmpvALVETWAREP-----WLLGEFMCKLVPFVE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 120 FCNIYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDM---KVEKSF-------CFEPLR 189
Cdd:cd14997   82 LTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFItefKEEDFNdgtpvavCRTPAD 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 190 MNSKIAgYHYLRFTFGFAIPLGILA---------FTNHQIFRSIKLSDSLSAAQKNK--VKRSAIAVVTIFLVCFAPYHV 258
Cdd:cd14997  162 TFWKVA-YILSTIVVFFVVPLAILSglysvicrrLVGHPALESRRADAANRHTLRSRrqVVYMLITVVVLFFVCLLPFRV 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 568980130 259 VLLVKAASFSFYQGDMDAVCAFESRLYTVSMVFLclstvNSVADPIIYVL 308
Cdd:cd14997  241 VTLWIIFAPDEDLQALGLEGYLNLLVFCRVMVYL-----NSALNPILYNL 285
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
71-304 3.27e-11

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 63.44  E-value: 3.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  71 RNVLAVYLFCLSLCELLYIST-VPLW-IIYIQNqhKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESR 148
Cdd:cd15927   32 RNVPNIFILSLALGDLLLLLTcVPFTsTIYTLD--SWPFGEFLCKLSEFLKDTSIGVSVFTLTALSADRYFAIVNPMRKH 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 149 GHRHQRTAVTISACVILLVGLVNYP--------VFDMKVEKSF--CFE-PLRMNSKIAGYH-YLRFTFGFAIPLGILAF- 215
Cdd:cd15927  110 RSQATRRTLVTAASIWIVSILLAIPeaifshvvTFTLTDNQTIqiCYPyPQELGPNYPKIMvLLRFLVYYLIPLLIIGVf 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 216 ------TNHQIFRSIKlSDSLSAAQKN-----KVKRSAIAVVTIFLVCFAPYHVVLLVkaasFSFYqgdMDAVCAFESRL 284
Cdd:cd15927  190 yvlmarHLIRSTRNIG-SGQNQAAQRQiearkKVAKTVLAFVVLFAVCWLPRHVFMLW----FHFA---PNGLVDYNAFW 261
                        250       260
                 ....*....|....*....|
gi 568980130 285 YTVSMVFLCLSTVNSVADPI 304
Cdd:cd15927  262 HVLKIVGFCLSFINSCVNPV 281
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
46-306 4.56e-11

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 63.26  E-value: 4.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLyISTVPLWIIYIQN-QHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15205    7 YVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLL-ITFFCIPFTLLQNiSSNWLGGAFMCKMVPFVQSTAVV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPV---------FDMKVEKSF--CFEPLRMNSK 193
Cdd:cd15205   86 TSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMlfvqqlevkYDFLYEKRHvcCLERWYSPTQ 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 194 IAGYHYLRFTFGFAIPLGILAFTNHQIF------RSIKLSDSLSAAQKNKVKRSA----------IAVVTIFLVCFAPYH 257
Cdd:cd15205  166 QKIYTTFILVILFLLPLTTMLFLYSRIGyelwikKRVGDASVLQTIHGIEMSKISrkkkravkmmVTVVLLFAVCWAPFH 245
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568980130 258 VVLLVKaaSFSFYQGDMDAVcafesrlyTVSMVFLCLSTV---NSVADPIIY 306
Cdd:cd15205  246 VVHMMI--EYSNLENKYDGV--------TIKLIFAIVQLIgfsNSFNNPIVY 287
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
46-262 5.37e-11

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 62.53  E-value: 5.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15166    7 YSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDE-WPFGDYFCRILGALTVFYPSI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEP---LRMNSKIAGYH---- 198
Cdd:cd15166   86 ALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLFLYEDPDKASNFttcLKMLDIIHLKEvnvl 165
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568980130 199 -YLRFTFGFAIPLGILAFTNHQIFRSI--KLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLV 262
Cdd:cd15166  166 nFTRLIFFFLIPLFIMIGCYLVIIHNLvhGRTSKLKPKVKEKSIRIIITLIVQVLVCFVPFHICFAF 232
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
77-306 6.52e-11

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 62.36  E-value: 6.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  77 YLFCLSLCELLYISTVPLWIIYIQ-NQHKWNLGPqackvtayiFFCNIYI---------SILLLCCISCDRYMAVVYALE 146
Cdd:cd15053   38 FIVSLAVADLLVAILVMPFAVYVEvNGGKWYLGP---------ILCDIYIamdvmcstaSIFNLCAISIDRYIAVTQPIK 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 147 SRGHRHQRTAVTISACVILLVGLVNYPVFdMKVEKSFCFEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKl 226
Cdd:cd15053  109 YARQKNSKRVLLTIAIVWVVSAAIACPLL-FGLNNVPYRDPEECRFYNPDFIIYSSISSFYIPCIVMLLLYYRIFRALR- 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 227 sdslsaAQKNKVKRSAIaVVTIFLVCFAPYHVVLLVKAASFSFYQGDmdavCAFESRLYtvsMVFLCLSTVNSVADPIIY 306
Cdd:cd15053  187 ------REKKATKTLAI-VLGVFLFCWLPFFTLNILNAICPKLQNQS----CHVGPALF---SLTTWLGYVNSFLNPIIY 252
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
119-311 7.43e-11

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 62.12  E-value: 7.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 119 FFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCfePLrmnSKIagyh 198
Cdd:cd15163   77 YFVNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSILTTAIKFASC--CL---SKL---- 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVK--RSAIAVVTIFLVCFAPYHVVLLVkaasfSFYQGDMDA 276
Cdd:cd15163  148 FALTVFEFFLPLLIITFFTIRIMCALSRPGLMHQSRERRMRavQLLITVLIIFMICFTPFHVRQVA-----VAFNPDIPH 222
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 568980130 277 VCAFesrlyTVSMVFLCLSTVNSVADPIIYVLGTD 311
Cdd:cd15163  223 HTSL-----IVYHVTVTLSSLNSCMDPIVYCFVTN 252
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
46-315 8.55e-11

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 62.14  E-value: 8.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWlTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15339    7 IGILCSTGLVGNILVLF-TIIRSRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDTCNQFA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF-DMKVEK-----SFCFEPLRMNSKIAGYHY 199
Cdd:cd15339   86 CSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWvYAKVIKfrdglESCAFNLTSPDDVLWYTL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 200 LRFTFGFAIPLG--------ILAFTNHQIFRSIKLSDSLSAAQKNKVKRSA---IAVVTIFLVCFAPYHVVLLVKAA--- 265
Cdd:cd15339  166 YQTITTFFFPLPlilicyilILCYTWEMYRKNKKAGRYNTSIPRQRVMRLTkmvLVLVGVFLVSAAPYHVIQLVNLSvsq 245
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568980130 266 -SFSFYQGdmdavcafesrlYTVSmvfLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15339  246 pTLAFYVS------------YYLS---ICLSYASSSINPFLYILLSGNFRK 281
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
46-316 9.80e-11

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 62.06  E-value: 9.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQnQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15087    7 YSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHL-LQQWPFGELLCKLILSIDHYNIFS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESR--GHRHQRTAVTISACVILLVGLVNYP------VFDMKVEKSFCF----EPLRMNSK 193
Cdd:cd15087   86 SIYFLTVMSVDRYLVVLATVRSRrmPYRTYRAAKIVSLCVWLLVTIIVLPftvfagVYSNELGRKSCVlsfpSPESLWFK 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 194 IAGYHYLrfTFGFAIPLG---ILAFTNHQIFRSIKLSDSLSAAQKNKVKRS--AIAVVTIFLVCFAPYHVVLLVkAASFS 268
Cdd:cd15087  166 ASRIYTL--VLGFAIPVSticILYTMMLYKLRNMRLNSNAKALDKAKKKVTlmVLVVLAVCLFCWTPFHLSTVV-ALTTD 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568980130 269 FYQGDMdavcafesrLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQE 316
Cdd:cd15087  243 LPQTPL---------VIGISYFITSLSYANSCLNPFLYAFLDDSFRKS 281
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
46-316 1.02e-10

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 61.66  E-value: 1.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANcltawLTLLQVLQRN-------VLAVYLFCLSLCELLY-ISTVPLWIIYIQNQHkWNLGPQACKVTAY 117
Cdd:cd15002    6 LGVICLLGFAGN-----LMVIGILLNNarkgkpsLIDSLILNLSAADLLLlLFSVPFRAAAYSKGS-WPLGWFVCKTADW 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 118 IFFCNIYISILLLCCISCDRYMAVVYALESRgHRHQRTAVTISACVILLVGLVNYPVF--------DMKVEKSFCFEPLR 189
Cdd:cd15002   80 FGHACMAAKSFTIAVLAKACYMYVVNPTKQV-TIKQRRITAVVASIWVPACLLPLPQWlfrtvkqsEGVYLCILCIPPLA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 190 MNSKIAgYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAI-----AVVTIFLVCFAPYHVvllvka 264
Cdd:cd15002  159 HEFMSA-FVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRNQIRSRKLthmllSVVLAFTILWLPEWV------ 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568980130 265 asFSFYQGDMDAvcAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQE 316
Cdd:cd15002  232 --AWLWLIHIKS--SGSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFREG 279
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
48-315 1.39e-10

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 61.13  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  48 AVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTV-PLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYIS 126
Cdd:cd15210    9 VFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNlPLAASTFLHQA-WIHGETLCRVFPLLRYGLVAVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 127 ILLLCCISCDRYMAVVY-ALESRGHRHQRTAVTISACVILLVGLVNYP----VFDMKVEKSFCFEPLRMNSKIAGYHYLR 201
Cdd:cd15210   88 LLTLVLITLNRYILIAHpSLYPRIYTRRGLALMIAGTWIFSFGSFLPLwlgiWGRFGLDPKVCSCSILRDKKGRSPKTFL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 202 FTFGFAIPLGILAFtnhqifrsiklsdSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAasfsfyqgdmdavcafE 281
Cdd:cd15210  168 FVFGFVLPCLVIII-------------CYARREDRRLTRMMLVIFLCFLVCYLPITLVNVFDD----------------E 218
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568980130 282 SRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15210  219 VAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
46-306 1.45e-10

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 61.31  E-value: 1.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQhkWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15184    7 YSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANE--WVFGNAMCKLLTGLYHIGFFS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP--VFDMKVEKSFCFE-----PLRMNSKIAGYH 198
Cdd:cd15184   85 GIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPgiIFTKSQKEGSHYTcsphfPPSQYQFWKNFQ 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YL-RFTFGFAIPLGILAFTNHQIFRSikLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDmdav 277
Cdd:cd15184  165 TLkMNILGLVLPLLVMIICYSGILKT--LLRCRNEKKRHKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNN---- 238
                        250       260
                 ....*....|....*....|....*....
gi 568980130 278 CAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15184  239 CSSSNRLDQAMQVTETLGMTHCCINPVIY 267
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
71-308 2.55e-10

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 60.78  E-value: 2.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  71 RNVLAVYLFCLSLCELLY-ISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRG 149
Cdd:cd15048   32 RTVSNFFLLNLAVADFLVgLVSMPFYIPYTLTGK-WPFGKVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 150 HRHQRTAVTISACVILLVGLVNYPVFdmkveksFCFEPLRMNSKI------AGYHY-LRFTFG-----FAIPLGILAFTN 217
Cdd:cd15048  111 KQTKRRTVLLMALVWILAFLLYGPAI-------IGWDLWTGYSIVptgdceVEFFDhFYFTFItsvleFFIPFISVSFFN 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 218 HQIFRSI-------------------------KLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVkaasFSFYQG 272
Cdd:cd15048  184 LLIYLNIrkrsrrrplrsvpilpasqnpsrarSQREQVKLRRDRKAAKSLAILVLVFLICWAPYTILTII----RSFCSG 259
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568980130 273 DMDAVCAFEsrlytvsmVFLCLSTVNSVADPIIYVL 308
Cdd:cd15048  260 SCVDSYLYE--------FTFWLLWTNSAINPFLYAA 287
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
105-315 4.12e-10

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 60.15  E-value: 4.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 105 WNLGPQACKVtaYIFFCNIY--ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF------- 175
Cdd:cd15012   65 WPFGEVLCRM--YQFVHSLSytASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFvfsqtve 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 176 -----DMKVEKSFCFEPLRMNSKIagYHYLRFTFGFAIPLGILAFTNHQIfrSIKLSDSLSAAQKNKVKRSAIAVVTIFL 250
Cdd:cd15012  143 ilvtqDGQEEEICVLDREMFNSKL--YDTINFIVWYLIPLLIMTVLYSKI--SIVLWKSSSIEARRKVVRLLVAVVVSFA 218
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568980130 251 VCFAPYHVVLLvkaasFSFYQGDMDAVCAFESRLYTVSMVFLCLstvNSVADPIIYVLGTDHSRQ 315
Cdd:cd15012  219 LCNLPYHARKM-----WQYWSEPYRCDSNWNALLTPLTFLVLYF---NSAVNPLLYAFLSKRFRQ 275
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
49-308 6.50e-10

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 59.25  E-value: 6.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  49 VCLLGLPAN---CLTAWLTllQVLQrNVLAVYLFCLSLCELLYISTV-PLWIIYIQNQHKWNLGPQACK--VTAYIFFCN 122
Cdd:cd15052   10 LVIATIGGNilvCLAISLE--KRLQ-NVTNYFLMSLAIADLLVGLLVmPLSILTELFGGVWPLPLVLCLlwVTLDVLFCT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 123 IyiSILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFePLRMNSKIAGYHYLRF 202
Cdd:cd15052   87 A--SIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDTTNV-LNNGTCVLFNPNFVIY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 203 --TFGFAIPLGILAFTnhqIFRSIKLsdsLSAAQKnKVKRSAIaVVTIFLVCFAPYHVVLLVKAASFSfyqgdmdAVCAF 280
Cdd:cd15052  164 gsIVAFFIPLLIMVVT---YALTIRL---LSNEQK-ASKVLGI-VFAVFVICWCPFFITNILTGLCEE-------CNCRI 228
                        250       260
                 ....*....|....*....|....*...
gi 568980130 281 ESRLYtvsMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15052  229 SPWLL---SVFVWLGYVSSTINPIIYTI 253
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
47-306 6.86e-10

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 59.29  E-value: 6.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  47 SAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTV-PLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15067    7 SLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVmPFSILHEMTGGYWLFGRDWCDVWHSFDVLASTA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP-------VFDMKVEKSFCFEPlrmnsKIAGYH 198
Cdd:cd15067   87 SILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPaiawwraVDPGPSPPNQCLFT-----DDSGYL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFGFAIPLGILAFTNHQIFRsiklsdslSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDMDavc 278
Cdd:cd15067  162 IFSSCVSFYIPLVVMLFTYYRIYR--------AAAKEQKAAKTLGIVMGVFILCWLPFFVTNILIGFCPSNCVSNPD--- 230
                        250       260
                 ....*....|....*....|....*...
gi 568980130 279 afesrlyTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15067  231 -------ILFPLVTWLGYINSGMNPIIY 251
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
46-317 8.73e-10

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 59.29  E-value: 8.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYI-STVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd14979    7 YVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILlVGLPVELYNFWWQYPWAFGDGGCKLYYFLFEACTY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESR---GHRHQRTAVT----ISACVILLVGL------VNYPVFDMKVEKSFCFEPLRMN 191
Cdd:cd14979   87 ATVLTIVALSVERYVAICHPLKAKtlvTKRRVKRFILaiwlVSILCAIPILFlmgiqyLNGPLPGPVPDSAVCTLVVDRS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 192 SKIAGYHYLRFTFgFAIP---LGILAF---------TNHQIFRSIKLSDSLSAAQKNKVKRSAI----AVVTIFLVCFAP 255
Cdd:cd14979  167 TFKYVFQVSTFIF-FVLPmfvISILYFrigvklrsmRNIKKGTRAQGTRNVELSLSQQARRQVVkmlgAVVIAFFVCWLP 245
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568980130 256 YHVVLLVKAASFSFYQGDMDavcaFESRLYTVSMVFLCLStvnSVADPIIYVLGTDHSRQEV 317
Cdd:cd14979  246 FHAQRLMFSYASKEDTFLFD----FYQYLYPISGILFYLS---SAINPILYNLMSSRFRVAF 300
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
75-306 1.87e-09

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 57.72  E-value: 1.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  75 AVYLFC-LSLCELLY-ISTVPLWIIYiQNQHKWNLGPqackvtayiFFCNIYI---------SILLLCCISCDRYMAVVY 143
Cdd:cd15064   35 ANYLIAsLAVADLLVaVLVMPLSAVY-ELTGRWILGQ---------VLCDIWIsldvtcctaSILHLCVIALDRYWAITD 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 144 ALESRGHRHQRTAVTISACVILLVGLVNY-PVFDMKVEKSFCFEPLRMNSKIAgyhYLRF-TFG-FAIPLGILAFTNHQI 220
Cdd:cd15064  105 AVEYAHKRTPKRAAVMIALVWTLSICISLpPLFGWRTPDSEDPSECLISQDIG---YTIFsTFGaFYIPLLLMLILYWKI 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 221 FRsiklsdslSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKaasfsfyqgdmdAVCAFESRLYTVSMVFLCLSTVNSV 300
Cdd:cd15064  182 YR--------AAARERKAAKTLGIILGAFIVCWLPFFLVALIV------------PLCSHCWIPLALKSFFLWLGYFNSL 241

                 ....*.
gi 568980130 301 ADPIIY 306
Cdd:cd15064  242 INPLIY 247
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
17-306 2.67e-09

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 57.99  E-value: 2.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  17 TSVLQSTSVPSSETCHVSYEESRV--VLVVVYSAVCLLGLPANCLTAWLTLLQVLQRnVLAVYLFCLSLCELLYISTVPl 94
Cdd:PHA02834   4 TVVVDNYSYYFEEECDFEMVNSDVnyFVIVFYILLFIFGLIGNVLVIAVLIVKRFMF-VVDVYLFNIAMSDLMLVFSFP- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  95 WIIYiQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRT---AVTISACVILLV--GL 169
Cdd:PHA02834  82 FIIH-NDLNEWIFGEFMCKLVLGVYFVGFFSNMFFVTLISIDRYILVVNATKIKNKSISLSvllSVAAWVCSVILSmpAM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 170 VNYPVFDMKVEKSFCFEPlrMNSKIAGYHYLRF---TFGFAIPLGILAFTNHQIFRSIKlsdslSAAQKNKVKRSAI--A 244
Cdd:PHA02834 161 VLYYVDNTDNLKQCIFND--YHENFSWSAFFNFeinIFGIVIPLIILIYCYSKILYTLK-----NCKNKNKTRSIKIilT 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568980130 245 VVTIFLVCFAPYHVVLLVKAAsfsFYQGDMDAVC-AFESRLYTVSMVFLcLSTVNSVADPIIY 306
Cdd:PHA02834 234 VVTFTVVFWVPFNIVLFINSL---QSVGLIDIGCyHFKKIVYSIDIAEL-ISFVHCCVNPIIY 292
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
98-307 5.91e-09

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 56.52  E-value: 5.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  98 YIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRhqRTAVTISACVILLVGLVNYP--VF 175
Cdd:cd15204   61 YVVRQRSWTHGDVLCAVVNYLRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKR--RTACVVIALVWVVSLLLAIPsaVY 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 176 DMKV-----EKSFCFE--PLRMNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSI-------KLSDSLSAAQKNKVK-- 239
Cdd:cd15204  139 SKTTpyanqGKIFCGQiwPVDQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVwfrrvpgQQTEQIRRRLRRRRRkv 218
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980130 240 RSAIAVVTIFLVCFAPYHVVLLVKaasfsfyqgDMDAVCAFESRLYTVSM-VFLCLSTVNSVADPIIYV 307
Cdd:cd15204  219 RLLVVILTAFVLCWAPYYGYAIVR---------DFFPTLLSKEKLNTTIFyIVEALAMSNSMINTVVYV 278
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
46-263 6.40e-09

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 56.67  E-value: 6.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYIST-VPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15394    7 YSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATcVPLTLAYAFEPRGWVFGRFMCYFVFLMQPVTVY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRhqRTAVTISACVILLVGLVNYPV-----------FDMKVEKSFCFEplrMNSK 193
Cdd:cd15394   87 VSVFTLTAIAVDRYYVTVYPLRRRISR--RTCAYIVAAIWLLSCGLALPAaahtyyvefkgLDFSICEEFWFG---QEKQ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 194 IAGYHYLRFTFGFAIPLGILAFTNHQIfrSIKLSDSL------------SAAQKNKVKRSAIAVVTIFLVCFAPYHVVLL 261
Cdd:cd15394  162 RLAYACSTLLITYVLPLLAISLSYLRI--SVKLRNRVvpgsmtqsqaewDRARRRKTFRLLVVVVVAFAICWLPLHIFNV 239

                 ..
gi 568980130 262 VK 263
Cdd:cd15394  240 IR 241
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
51-306 9.04e-09

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 56.29  E-value: 9.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  51 LLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY----ISTVPLWIIYIQnqhkWNLGPQACKVTAYIFFCNIYIS 126
Cdd:cd15384   12 VISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVtffcIPSEAIWAYTVA----WLAGNTMCKLVKYLQVFGLYLS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 127 ILLLCCISCDRYMAVVYALeSRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFcFEPLRMNSKIAG---------- 196
Cdd:cd15384   88 TYITVLISLDRCVAILYPM-KRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVERGP-FVEDFHQCVTYGfytaewqeql 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 YHYLRFTFGFAIPLGILAFTNHQIFRSIK---------LSDSLSAAQ---------KNKVKRSAIAVVTIFLVCFAPYHV 258
Cdd:cd15384  166 YNMLSLVFMFPIPLVIMVTCYVLIFITLSkssrdfqglEIYTRNRGPnrqrlfhkaKVKSLRMSAVIVTAFILCWTPYYV 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568980130 259 VLLVkaasFSFYQGDMDAvcafesrlYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15384  246 IMIW----FLFFNPYPLN--------DILFDVIFFFGMSNSCVNPLIY 281
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
89-308 9.63e-09

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 56.10  E-value: 9.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  89 ISTVPLWIIYIQNQhKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYAL---ESRGHRHQR---TAVTISAC 162
Cdd:cd14981   54 LTSPVVLAVYASNF-EWDGGQPLCDYFGFMMSFFGLSSLLIVCAMAVERFLAITHPFfynSHVKKRRARlmlGAVWAFAL 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 163 VILLVGLVNYPVFDMKVEKSFCFepLRMNSKI---AGYHYLRFTFGFAIPLGILAF-------TNHQIFRSIKLSDSLSA 232
Cdd:cd14981  133 LIASLPLLGLGSYVLQYPGTWCF--LDFYSKNtgdAAYAYLYSILGLLILLVTLLCnllviitLLRMRRRKKRHRRSRRS 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 233 AQKNkvKRSAI-------AVVTIFLVCFAPYHVVLLVKAASFSFYQGDMDavcafesrlytvsMVFLCLSTVNSVADPII 305
Cdd:cd14981  211 ARRQ--KRNEIqmvvlllAITVVFSVCWLPLMIRVLINATGDSEKNGKTD-------------LLAVRMASWNQILDPWV 275

                 ...
gi 568980130 306 YVL 308
Cdd:cd14981  276 YIL 278
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
89-316 9.82e-09

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 55.84  E-value: 9.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  89 ISTVPLWIIYIQnqhkWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQ-RTAVTISACVILLV 167
Cdd:cd14986   54 VLTQIIWEATGE----WVAGDVLCRIVKYLQVVGLFASTYILVSMSLDRYQAIVKPMSSLKPRKRaRLMIVVAWVLSFLF 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 168 GLVNYPVFdMKVEKSFCFEPLRMNSKIAGYHYLRFTFG----FAIPLGILAFTNHQIFRSI----------------KLS 227
Cdd:cd14986  130 SIPQLVIF-VERELGDGVHQCWSSFYTPWQRKVYITWLatyvFVIPLIILSYCYGRILRTIwirsrqktdrpiaptaMSC 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 228 DSLSAAQ---------KNKVKRSAIAVVTIFLVCFAPYHVVLLVKAasFSFYQGDmdavcafESRLYTVSMVflcLSTVN 298
Cdd:cd14986  209 RSVSCVSsrvslisraKIKTIKMTLVIILAFILCWTPYFIVQLLDV--YAGMQQL-------ENDAYVVSET---LASLN 276
                        250
                 ....*....|....*...
gi 568980130 299 SVADPIIYVLGTDHSRQE 316
Cdd:cd14986  277 SALNPLIYGFFSSHLSFE 294
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
46-263 1.11e-08

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 55.88  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLyistVPLWIIYIQNQ----HKWNLGPQACKVTAYIFFC 121
Cdd:cd15393    7 YGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADII----IGLFSIPFQFQaallQRWVLPRFMCPFCPFVQVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 122 NIYISILLLCCISCDRYMAVVYALESRGHRhQRTAVTISACVILLVG-----LVNYPVFDM-----KVEKSFCFEPLRMN 191
Cdd:cd15393   83 SVNVSVFTLTVIAVDRYRAVIHPLKARCSK-KSAKIIILIIWILALLvalpvALALRVEELtdktnNGVKPFCLPVGPSD 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 192 SKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQ----------KNKVKRSAIAVVTIFLVCFAPYHVVLL 261
Cdd:cd15393  162 DWWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGNAQdvrddeilknKKKVIKMLIIVVALFALCWLPLQTYNL 241

                 ..
gi 568980130 262 VK 263
Cdd:cd15393  242 LN 243
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
46-317 1.38e-08

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 55.57  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15928    7 CSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCTYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDM-KVEKSFCFEPLRMN--------SKIAG 196
Cdd:cd15928   87 SILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLvGVEHIQGQQTPRGFectvvnvsSGLLS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 YHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAA---------QKNKVKRSAIaVVTIFLVCFAPYHVVLLVkaasF 267
Cdd:cd15928  167 VMLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRTagasrrdnnHRQTVRMLAV-IVLAFVLCWLPFHVGRVI----F 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 568980130 268 SFYQGDMDAVCAFESRLYTVSMVFLCLStvnSVADPIIYVLGTDHSRQEV 317
Cdd:cd15928  242 NHSRASTKHLHYVSQYFNLVSFVLFYLS---AAINPILYNLMSKRYRYAV 288
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
76-315 2.57e-08

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 54.51  E-value: 2.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  76 VYLFCLSLCELLYIStvplwiIYIQNQHKWNLGPQaCKVTAYIFFCNIYISILLLCCISCDRYMAVVYALeSRGHRHQRT 155
Cdd:cd15137   51 VYLLIIASVDLYYRG------VYIKHDEEWRSSWL-CTFAGFLATLSSEVSVLILTLITLDRFICIVFPF-SGRRLGLRR 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 156 AVTISACV-ILLVGLVNYPVFDMKVEKSF------CFePLRM-NSKIAGYHYLRFTF---GFAIPLGILaFTNHQIFRSI 224
Cdd:cd15137  123 AIIVLACIwLIGLLLAVLPLLPWDYFGNFygrsgvCL-PLHItDERPAGWEYSVFVFlglNFLAFVFIL-LSYIAMFISI 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 225 KLSDSLSAAQKNK-----VKRSAIAVVTIFLvCFAPyhvVLLVKAASFSFYQ--GDMDAVCAfesrlytvsmVFLClsTV 297
Cdd:cd15137  201 RRTRKAAASRKSKrdmavAKRFFLIVLTDFL-CWIP---IIVIGILALSGVPipGEVYAWVA----------VFVL--PI 264
                        250
                 ....*....|....*...
gi 568980130 298 NSVADPIIYVLGTDHSRQ 315
Cdd:cd15137  265 NSALNPILYTLSTPKFRK 282
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
103-306 3.39e-08

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 54.16  E-value: 3.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 103 HKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRhqRTAVTISACVILLVGLVNYPVFDMKVEK- 181
Cdd:cd15207   64 TGWPFGDVMCKLSPLVQGVSVAASVFTLVAIAVDRYRAVVHPTEPKLTN--RQAFVIIVAIWVLALAIMIPQALVLEVKe 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 182 ---------SFCFE--PLRMNSKIagYHYLRFTFGFAIPLGILAFTNHQI----------FRSIKLSDSLSAAQKNKVK- 239
Cdd:cd15207  142 yqffrgqtvHICVEfwPSDEYRKA--YTTSLFVLCYVAPLLIIAVLYVRIgyrlwfkpvpGGGSASREAQAAVSKKKVRv 219
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980130 240 -RSAIAVVTIFLVCFAPYHVV-LLVKAASFSFYQGDMDAVCAFEsrlytvsmVFLCLSTVNSVADPIIY 306
Cdd:cd15207  220 iKMLIVVVVLFALSWLPLHTVtMLDDFGNLSPNQREVLYVYIYP--------IAHWLAYFNSCVNPIVY 280
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
72-317 3.70e-08

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 54.26  E-value: 3.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  72 NVLAVYLFC---------------LSLCE-LLYISTVPLwIIYIQNQHKWNLGPQACKVTAY---IFFCNiyiSILLLCC 132
Cdd:cd15083   18 NGLVIYAFCrfkslrtpanyliinLAISDfLMCILNCPL-MVISSFSGRWIFGKTGCDMYGFsggLFGIM---SINTLAA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 133 ISCDRYMAVVYALESRGH-RHQRTAVTISACVILLVGLVNYPVFDM------KVEKSFCFEPLRMNSKIAGYHYLRFTFG 205
Cdd:cd15083   94 IAVDRYLVITRPMKASVRiSHRRALIVIAVVWLYSLLWVLPPLFGWsryvleGLLTSCSFDYLSRDDANRSYVICLLIFG 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 206 FAIPLGILAFTNHQIFRSI------------KLSDSLSAAQKNKVKRS------AIAVVTIFLVCFAPYHVVLLVKAAsf 267
Cdd:cd15083  174 FVLPLLIIIYCYSFIFRAVrrhekamkemakRFSKSELSSPKARRQAEvktakiALLLVLLFCLAWTPYAVVALIGQF-- 251
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 568980130 268 sfyqGDMDAVCAfesrlyTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15083  252 ----GYLEVLTP------LATAIPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
91-265 5.91e-08

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 53.29  E-value: 5.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  91 TVPLWIIYiQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRG-HRHQRTAVTISACVILLVGL 169
Cdd:cd15295   53 SIPLYIPY-TLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLISYDRYQSVSNAVSYRNqQTATLRIVTQMVAVWVLAFL 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 170 VNYPVF----DMKVEKSFCfeplrMNSKIAGYHYLRFT--FGFAIPLGILAFTNHQIFRSIKlsdslSAAQKNKVKRSAI 243
Cdd:cd15295  132 VHGPAIlvsdSWKTEDGEC-----EPEFFSNWYILAITsvLEFLVPVILVAYFNTQIYWSLW-----KRLRDRKLAKSLA 201
                        170       180
                 ....*....|....*....|..
gi 568980130 244 AVVTIFLVCFAPYHVVLLVKAA 265
Cdd:cd15295  202 IILGTFAICWAPYSLFTIIRAA 223
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
74-307 6.35e-08

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 53.04  E-value: 6.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  74 LAVYLFCLSLCELlyistvPLWIIYiQNQHKWNLGPqackvtayiFFCNIYI---------SILLLCCISCDRYMAVVYA 144
Cdd:cd15329   42 LAVSDLLVALLVM------PLAIIY-ELSGYWPFGE---------ILCDVWIsfdvllctaSILNLCAISVDRYLVITRP 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 145 LESRGHRHQRTAVTISACVILLVGLVNY-PVFDMKVEKSfcFEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRs 223
Cdd:cd15329  106 LTYAVKRTPKRMALMIAIVWLLSALISIpPLFGWKNKVN--DPGVCQVSQDFGYQIYATFGAFYIPLIVMLVLYYKIYR- 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 224 iklsdslsAAQKN-KVKRSAIAVVTIFLVCFAPYHVVLLVKaasfSFYQGDMdaVCAFESRLytvSMVFLCLSTVNSVAD 302
Cdd:cd15329  183 --------AAKSErKAIKTLGIIMGAFTLCWLPFFILALLR----PFLKPIK--CSCIPLWL---SRLFLWLGYANSFLN 245

                 ....*
gi 568980130 303 PIIYV 307
Cdd:cd15329  246 PIIYA 250
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
77-315 8.05e-08

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 53.10  E-value: 8.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  77 YLFCLSLCELLY-ISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRT 155
Cdd:cd15134   38 YLFSLAVSDLLLlILGLPFELYTIWQQYPWVFGEVFCKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSR 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 156 AVTISACVILL-------------VGLVNYPVFDMKV--EKSFCfEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTNHQI 220
Cdd:cd15134  118 AIRIIIAIWIIafvcalpfaiqtrIVYLEYPPTSGEAleESAFC-AMLNEIPPITPVFQLSTFLFFIIPMIAIIVLYVLI 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 221 FRSIKLSDSLSAAQKNK------------VKRSAIAVVTIFLVCFAPYHVVLLVkaasfSFYQGDMDAVCAFESR-LYTV 287
Cdd:cd15134  197 GLQLRRSTLLRRGQRSVsggrrssqsrrtVLRMLVAVVVAFFICWAPFHAQRLL-----TVYAKNMTPPYLFINRiLFYI 271
                        250       260
                 ....*....|....*....|....*....
gi 568980130 288 SMVFLCLS-TVNsvadPIIYVLGTDHSRQ 315
Cdd:cd15134  272 SGVLYYVSsTVN----PILYNVMSAKYRQ 296
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
71-314 1.01e-07

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 52.90  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  71 RNVLAVYLFCLSLCEL-LYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRg 149
Cdd:cd15391   32 RTDLNYYLINLAVSDLiMALFCMPFTFTQIMLGH-WVFPAPMCPIVLYVQLVSVTASVLTNTAIGIDRFFAVIFPLRSR- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 150 HRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRM---------NSKIAGYHYLRFTFGFAIPLGILAFTNHQI 220
Cdd:cd15391  110 HTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQYSEGRVlcgeswpgpDTSRSAYTVFVMLLTYIIPLLILTSTYGYV 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 221 FR----------SIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDMDAVCAFESRLYTVSMv 290
Cdd:cd15391  190 GFrlwnrtapgnADKGRDDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNLVQDFSTVFRNMPQHTTRLIYGACHWIAM- 268
                        250       260
                 ....*....|....*....|....
gi 568980130 291 flclstVNSVADPIIYVLGTDHSR 314
Cdd:cd15391  269 ------SNSFVNPIIYLFMNDSFR 286
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-306 1.12e-07

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 52.63  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCE--LLYISTVPLWIIYIQNQhkWNLGPQACKVTAYIFFCNI 123
Cdd:cd16003    7 YGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDasMAAFNTLINFIYALHSE--WYFGEAYCRFHNFFPITSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 124 YISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISA---CVILLVGLVNYPVFDMKVEKSFCFE--PLRMNSKIAgYH 198
Cdd:cd16003   85 FASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIwilAFLLAFPQCLYSKTKVMPGRTLCFVawPGGPDQHFT-YH 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFGFAIPLGILAFTNHQIFRSI-----------KLSDSLSAaqKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASF 267
Cdd:cd16003  164 IIVIVLVYCLPLLVMGITYTIVGITLwggeipgdtsdKYHEQLRA--KRKVVKMMIIVVLTFAICWLPYHIYFIVTGLYQ 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568980130 268 SFyqgdmdavcafeSRLYTVSMVFLC---LSTVNSVADPIIY 306
Cdd:cd16003  242 QL------------NRWKYIQQVYLAsfwLAMSSTMYNPIIY 271
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
48-308 1.13e-07

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 52.64  E-value: 1.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  48 AVCLLGLPANCLTAWLTLLQVlQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPqACKVTAYIFFCNIYISI 127
Cdd:cd14973    9 LLSLCGLVGNGLVLWLLGFRI-KRNPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSLPGFA-LCRLLATLMFFSYTVGL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 128 LLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP------VFDMKVEKSFCFEplrmnskiagYHYLR 201
Cdd:cd14973   87 SLLAAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVLesyfcgFLFWKFNESACRT----------FNFLS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 202 FTFGFaIPLGILAFTNHQIFrsIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYqgdmdavcafe 281
Cdd:cd14973  157 ALLFL-LLFLVMCVSSLTLL--IRVQCSSQRRPPTRLYVVILLTVLVFLLCGLPLGIYWFLLLWFSNYL----------- 222
                        250       260
                 ....*....|....*....|....*..
gi 568980130 282 srLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd14973  223 --FHTFHPISDLLSCVNSSANPIIYFF 247
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
46-308 1.30e-07

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 52.56  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELL-YISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15357    7 YAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLvLLFGMPLEVYEMWSNYPFLFGPVGCYFKTALFETVCF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVY----ALESRGHRHQRTAVTISACVILL---------VGLVNYPVFDMKVEKSFC--FEPLR 189
Cdd:cd15357   87 ASILSVTTVSVERYVAILHpfraKLNSTRERALKIIVVLWVLSVLFsipntsihgIKLQYFPNGTLIPDSATCtvVKPLW 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 190 MNSKIAGYHYLRFtfgFAIPLGILAFTNHQIFRSIKLSDSLSAAQKN---------KVKRSAIAVVTIFLVCFAPYHVVL 260
Cdd:cd15357  167 IYNLIIQITSLLF---YVLPMGVISVLYYLMGLKLRGDKSLEADEMNvniqrpsrkSVTKMLFVLVLVFAICWAPFHVDR 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568980130 261 LVkaasFSFYQGDMDAVCAFESRLYTVSMVFLCLStvnSVADPIIYVL 308
Cdd:cd15357  244 LF----FSFVVEWTEPLANVFNLIHVVSGVFFYLS---SAVNPIIYNL 284
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
49-308 1.45e-07

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 52.40  E-value: 1.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  49 VCLLGLPANCLTAWLTLLQVlQRNVLAVYLFCLSLCELLYI-STVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIY-IS 126
Cdd:cd15110   10 ICLLGLVGNGIVLWFLGFRI-RRNPFTVYILHLAIADFTFLlCIFILSIMYIGPFNFSHSRDYVAMLIFIILFLFGYnTG 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 127 ILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNypvfdmKVEKSFCfeplrmnsKIAGYH---YLRFT 203
Cdd:cd15110   89 LYLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWALSVLMT------SLEYLMC--------IDEGFHvrnECRAV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 204 FGFAIPLGILAFTNHQIFRS----IKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLvkaasFSFYQgdmdavca 279
Cdd:cd15110  155 LIFIGILTFLVFTPLMLISSlilfIKVRCNSQRRHPGKLYIIIMLTVIFFLIFAMPMRVLLL-----LNYLH-------- 221
                        250       260
                 ....*....|....*....|....*....
gi 568980130 280 fESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15110  222 -HSSFLFSNPVPFLLSTVNSSINPIVYFL 249
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
72-306 1.77e-07

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 52.19  E-value: 1.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  72 NVLAVYLFC---------------LSLCELLYISTVPLWIIYIQNQhKWNLGPQACKVTAYIFFCNIYISILLLCCISCD 136
Cdd:cd15079   18 NGLVIYIFSttkslrtpsnmlvvnLAISDFLMMIKMPIFIYNSFYE-GWALGPLGCQIYAFLGSLSGIGSIWTNAAIAYD 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 137 RYMAVVYALESRGHRHQRTAVTISACVI---------LLVGLVNYpvfdmkVEKSF---C-FEPLRMNSKIAGYHYLRFT 203
Cdd:cd15079   97 RYNVIVKPLNGNPLTRGKALLLILFIWLyalpwallpLLFGWGRY------VPEGFltsCsFDYLTRDWNTRSFVATIFV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 204 FGFAIPLGILAFTNHQIFRSIK--------------LSDSLSAAQKNKVK------RSAIAVVTIFLVCFAPYHVVLLvk 263
Cdd:cd15079  171 FAYVIPLIIIIYCYSFIVKAVFahekalreqakkmnVVSLRSNADANKQSaeiriaKVALTNVFLWFIAWTPYAVVAL-- 248
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568980130 264 aasfsfyqgdmdaVCAFESR-LYT--VSMVFLCLSTVNSVADPIIY 306
Cdd:cd15079  249 -------------IGAFGNQsLLTplVSMIPALFAKTAACYNPIVY 281
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
64-304 2.17e-07

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 51.78  E-value: 2.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  64 TLLQVL-----QRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRY 138
Cdd:cd15976   20 TLLRIIyknkcMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 139 MAVVYALESRGHRHQR-TAVTISACVILLVGL-----VNYPVFDMKVEKSFC----FEPLRMNSKIAGYHYLR----FTF 204
Cdd:cd15976  100 RAVASWSRIKGIGVPKwTAVEIVLIWVVSIILavpeaIGFDMITMDYKGELLriclLHPIQKTAFMQFYKTAKdwwlFSF 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 205 GFAIPLGILAF----TNHQIFR-----SIKLSDSLSaaQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKaasFSFYQGDMD 275
Cdd:cd15976  180 YFCLPLACTAVfytlMTCEMLRkkngmQIALNDHLK--QRREVAKTVFCLVLVFALCWLPLHLSRILK---LTIYDEKDP 254
                        250       260
                 ....*....|....*....|....*....
gi 568980130 276 AVCAFESRLYTVSMVFLCLSTVNSVADPI 304
Cdd:cd15976  255 NRCELLSFFLVLDYIGINMASLNSCINPI 283
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
79-308 2.63e-07

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 51.55  E-value: 2.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  79 FCLSL-CELLYISTV--PLWIIYIQnQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRT 155
Cdd:cd15049   38 FLLSLaCADLIIGLVsmNLYTVYLV-MGYWPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKR 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 156 AVTISACVILLVGLVNYP--------VFDMKVEKSFCFEPLrMNSKIagyhylrFTFG-----FAIPLGILAFTNHQIFR 222
Cdd:cd15049  117 AILMIALAWVISFVLWAPailgwqyfVGERTVPDGQCYIQF-LDDPA-------ITFGtaiaaFYLPVLVMTILYWRIYR 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 223 SIklsdslsaAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASfsfyqgdmdAVCAFEsRLYTVSMvFLCLstVNSVAD 302
Cdd:cd15049  189 ET--------ARERKAARTLSAILLAFIITWTPYNILVLVSTFC---------AKCIPD-TLWSFGY-WLCY--INSTIN 247

                 ....*.
gi 568980130 303 PIIYVL 308
Cdd:cd15049  248 PFCYAL 253
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
105-306 2.65e-07

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 51.21  E-value: 2.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 105 WNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVG---LVNYPVFDMKVEK 181
Cdd:cd15213   66 WIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLIIVQRQDKLNPHRAKILIAVSWVLSFCVSfppLVGWGKYEFPPRA 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 182 SFCFEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKlsdslsaAQKNKVKRSAIAVVTIFLVCFAPYHVVLL 261
Cdd:cd15213  146 PQCVLGYTESPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVR-------SFKTRAFTTILILFIGFSVCWLPYTVYSL 218
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568980130 262 VkaASFSFYQgdmdavcafeSRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15213  219 L--SVFSRYS----------SSFYVISTCLLWLSYLKSAFNPVIY 251
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
96-306 5.51e-07

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 50.49  E-value: 5.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  96 IIYIQNQHK-WNLGPQACKVTAyifFCNIYI---SILLLCCISCDRYMAVVYALES-RGHRHQRTAVTISACVILLVGLV 170
Cdd:cd15336   56 IFFVNSLHKrWIFGEKGCELYA---FCGALFgitSMITLLAISLDRYLVITKPLASiRWVSKKRAMIIILLVWLYSLAWS 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 171 NYPVFDMKvekSFCFEPLR-------MNSKIA--GYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDS------------ 229
Cdd:cd15336  133 LPPLFGWS---AYVPEGLLtsctwdyMTFTPSvrAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGRevqklgsqdrke 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 230 ---LSAAQKNKVKRSAIAVVTI--FLVCFAPYHVVLLVKAASFSF----YQGDMDAVCAFESRLYtvsmvflclstvnsv 300
Cdd:cd15336  210 kakQYQRMKNEWKMAKIAFVVIllFVLSWSPYACVALIAWAGYAHlltpYMKSVPAVIAKASAIY--------------- 274

                 ....*.
gi 568980130 301 aDPIIY 306
Cdd:cd15336  275 -NPIIY 279
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-314 6.15e-07

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 50.63  E-value: 6.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCE--LLYISTVPLWIIYIQNQhkWNLGPQACKVTAYIFFCNI 123
Cdd:cd16002    7 YSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEasMSAFNTVINFTYAIHNE--WYYGLEYCKFHNFFPIAAV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 124 YISILLLCCISCDRYMAVVYALESRghrHQRTAVTISACVI-LLVGLVNYPVFDMKVEKSF-----CF-----EPLRMNS 192
Cdd:cd16002   85 FASIYSMTAIALDRYMAIIHPLQPR---LSATATKVVICVIwVLAFLLAFPQGYYSDTEEMpgrvvCYvewpeHEERKYE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 193 KiaGYHYLRFTFGFAIPLgiLAFTNHQIFRSIKLSDS-----------LSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLL 261
Cdd:cd16002  162 T--VYHVCVTVLIYFLPL--LVIGCAYTVVGITLWASeipgdssdryhEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFL 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568980130 262 VKAASFSFYQgdmdavcafESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSR 314
Cdd:cd16002  238 LQYFHPELYE---------QKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFR 281
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
46-262 9.17e-07

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 49.73  E-value: 9.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLyISTVPLWIIYIQNQHKWNLGPQA-CKVTAYIFFCNIY 124
Cdd:cd14964    5 LSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLL-ASLVVLVLFFLLGLTEASSRPQAlCYLIYLLWYGANL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRMNSKIAGYHYLRF-- 202
Cdd:cd14964   84 ASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYLICTTIYLTWgf 163
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568980130 203 -TFGFAIPLGILAFTNHQIF-------RSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLV 262
Cdd:cd14964  164 lLVSFLLPLVAFLVIFSRIVlrlrrrvRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFIL 231
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
64-304 1.12e-06

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 49.90  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  64 TLLQVL-----QRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRY 138
Cdd:cd15977   20 TLLRIIyknkcMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITVLSLCALSIDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 139 MAVVYALESRG---HRHQRTAVTISACVILLVGLVNYPVFDMkVEKSF-------CFEPLRMNSKIAGYH-----YLRFT 203
Cdd:cd15977  100 RAVASWSRIRGigiPVWKAVEVTLIWAVAIIVAVPEAIAFDM-VEIDYrgqtllvCMLPMEQTSSFMRFYqdvkdWWLFG 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 204 FGFAIPLGILAF---------TNHQIFRSIKLSDSLSaaQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASfsfYQGDM 274
Cdd:cd15977  179 FYFCLPLACTGVfytlmscemLSIKNGMRIALNDHMK--QRREVAKTVFCLVVIFALCWLPLHLSRILKKTI---YDVKD 253
                        250       260       270
                 ....*....|....*....|....*....|
gi 568980130 275 DAVCAFESRLYTVSMVFLCLSTVNSVADPI 304
Cdd:cd15977  254 PQRCELLSFLLVMDYTGINMASLNSCINPV 283
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
104-308 1.23e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 49.35  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 104 KWNLGPQACKVTAY--IFFCniYISILLLCCISCDRYM-----AVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFD 176
Cdd:cd15073   65 SWKFGYAGCQWYAFlnIFFG--MASIGLLTVVAVDRYLticrpDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYA 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 177 MKVEKSFCFEPLRMN-SKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKL---SDSLSAA------QKNKVKRSAIAVV 246
Cdd:cd15073  143 LDPTGATCTINWRKNdSSFVSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKvlaSDCLESVnidwtdQNDVTKMSVIMIV 222
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568980130 247 TiFLVCFAPYHVVLLVkaASFsfyqGDMDAVCAFesrLYTVSMVFLCLSTvnsVADPIIYVL 308
Cdd:cd15073  223 M-FLVAWSPYSIVCLW--ASF----GEPKKIPPW---MAIIPPLFAKSST---FYNPCIYVI 271
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
46-306 1.32e-06

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 49.31  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLWIIYiQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15206    7 YSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLaVFCMPFTLVG-QLLRNFIFGEVMCKLIPYFQAVSVS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILL--VGLVNYPVFDMKVEKS-----FCFEPLRMNSKIAGY 197
Cdd:cd15206   86 VSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLsfLIMSPILVFSNLIPMSrpgghKCREVWPNEIAEQAW 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 HYLRFTFGFAIPLGILAFTNHQIFRSIKLSdslsaaqKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAasfsfyqgdMDAV 277
Cdd:cd15206  166 YVFLDLMLLVIPGLVMSVAYGLISWTLLEA-------KKRVIRMLFVIVVEFFICWTPLYVINTWKA---------FDPP 229
                        250       260
                 ....*....|....*....|....*....
gi 568980130 278 CAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15206  230 SAARYVSSTTISLIQLLAYISSCVNPITY 258
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
46-308 1.33e-06

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 49.45  E-value: 1.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYIST-VPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15133    7 YLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLgMPLELYELWQNYPFLLGSGGCYFKTFLFETVCL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP---------------------------VFDM 177
Cdd:cd15133   87 ASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPntslhgikflgsgvpasaqctvrkpqaIYNM 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 178 KVE-KSFCFEPLRMnsKIAGYHYLRFTFGFAIPLGILAftnhQIFRSIKLSDSLSAAQKNKVKRSA----IAVVTIFLVC 252
Cdd:cd15133  167 IPQhTGHLFFVLPM--AVISVLYLLMALRLARERGLDA----TGAGSKIGTRTGQLLQHPRTRAQVtkmlFILVVVFAIC 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568980130 253 FAPYHVVLLVkaasFSFYQGDMDAVCAFESRLYTVSMVFLCLStvnSVADPIIYVL 308
Cdd:cd15133  241 WAPFHIDRLM----WSFISDWTDNLHEVFQYVHIISGVFFYLS---SAVNPILYNL 289
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
99-306 1.52e-06

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 48.91  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  99 IQNQHKWNLGPQACKV--TAYIFFCNIyiSILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNY-PVF 175
Cdd:cd15066   59 VEITGRWMFGYFMCDVwnSLDVYFSTA--SILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFlPIF 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 176 DMKVEKSFCFEPLRMNSKIAG------YHYLRFTFGFAIPLGILAFTNHQIFRsiklsdslSAAQKNKVKRSAIAVVTIF 249
Cdd:cd15066  137 LGWYTTEEHLQYRKTHPDQCEfvvnkiYALISSSVSFWIPCIVMIFTYYRIYL--------EAKREHKAAKTLGIIMGAF 208
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568980130 250 LVCFAPYhvvllvkaasFSFYQGDM--DAVCAFESRLytVSMVFLcLSTVNSVADPIIY 306
Cdd:cd15066  209 ILCWLPF----------FLWYVTTTlcGDACPYPPIL--VSILFW-IGYFNSTLNPLIY 254
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
46-262 1.65e-06

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 49.05  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLyISTV--PLWIIYIQnQHKWNLGPQACKVTAYIFFCNI 123
Cdd:cd15399    7 YCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLM-VNTLclPFTLVYTL-LDEWKFGAVLCHLVPYAQALAV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 124 YISILLLCCISCDRYMAVVYALESRGHRhqRTAVTISACVILLVGLVNYP----------VFDMKVEKSFCFE--PLRMN 191
Cdd:cd15399   85 HVSTVTLTVIALDRHRCIVYHLESKISK--KISFLIIGLTWAASALLASPlaifreysviEISPDFKIQACSEkwPNGTL 162
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568980130 192 SKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAA------QKNKVKRSAIAVVTIFLVCFAPYHVVLLV 262
Cdd:cd15399  163 NDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGndhyhqRRRKTTKMLVCVVVVFAVSWLPFHAFQLA 239
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
46-316 1.98e-06

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 48.93  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLWIIYiQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15195    7 TWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVtFFNMPMDAVW-NYTVEWLAGDLMCRVMMFLKQFGMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALesrGHRHQRTAVTISACVILLVGLVNypvfdmKVEKSFCFEPLRMNSKIAGYH------ 198
Cdd:cd15195   86 LSSFMLVVIALDRVFAILSPL---SANQARKRVKIMLTVAWVLSALC------SIPQSFIFSVLRKMPEQPGFHqcvdfg 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 ----------YLRFTF--GFAIPLGIL--------------AFTNHQIFRSIKLSDSLSAAQ--KNKVKRSAIAVVTIFL 250
Cdd:cd15195  157 saptkkqerlYYFFTMilSFVIPLIITvtcyllilfeiskmAKRARDTPISNRRRSRTNSLEraRMRTLRMTALIVLTFI 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568980130 251 VCFAPYHVVLLvkaasfsFYQGDMDAVCAFESRLYTVSMVFLCLstvNSVADPIIYVLGTDHSRQE 316
Cdd:cd15195  237 VCWGPYYVLGL-------WYWFDKESIKNLPPALSHIMFLLGYL---NPCLHPIIYGVFMKEIRNW 292
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
48-308 1.99e-06

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 48.65  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  48 AVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKV--TAYIFFCNIyi 125
Cdd:cd15063    9 FLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIwlAVDVWMCTA-- 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRMNSKIA---------G 196
Cdd:cd15063   87 SILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSLPctceltngrG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 YHYLRFTFGFAIPLGILAFTNHQIFRsiklsdslSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAasfsFYQGDMDA 276
Cdd:cd15063  167 YVIYSALGSFYIPMLVMLFFYFRIYR--------AARMETKAAKTVAIIVGCFIFCWLPFFTVYLVRA----FCEDCIPP 234
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568980130 277 VcafesrlytVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15063  235 L---------LFSVFFWLGYCNSALNPCIYAL 257
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
133-308 2.03e-06

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 48.83  E-value: 2.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 133 ISCDRYMAVVYALE-SRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRMNSKIAgYHYLRFTFG-FAIPL 210
Cdd:cd14972   91 IAVDRYISIVHGLTyVNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVLCDQESCSPLGPGLP-KSYLVLILVfFFIAL 169
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 211 GILAFTNHQIFRSIK--------LSDSLSAAQKNKVKRSAIAVVTI---FLVCFAPYHVVLLVkaasfsfyqgdmDAVCA 279
Cdd:cd14972  170 VIIVFLYVRIFWCLWrhanaiaaRQEAAVPAQPSTSRKLAKTVVIVlgvFLVCWLPLLILLVL------------DVLCP 237
                        170       180
                 ....*....|....*....|....*....
gi 568980130 280 FESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd14972  238 SVCDIQAVFYYFLVLALLNSAINPIIYAF 266
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
58-306 2.25e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 48.44  E-value: 2.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  58 CLTAWLTLLQVLQrNVLAVYLFCLSLCELLY-ISTVPLWIIYiQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCD 136
Cdd:cd15330   20 CVVAAIALERSLQ-NVANYLIGSLAVTDLMVsVLVLPMAALY-QVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 137 RYMAVVYALESRGHRH-QRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRMNSKIAGYhYLRFTFG-FAIPLGILA 214
Cdd:cd15330   98 RYWAITDPIDYVNKRTpRRAAVLISLTWLIGFSISIPPMLGWRTPEDRSDPDACTISKDPGY-TIYSTFGaFYIPLILML 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 215 FTNHQIFRsiklsdslSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVkaasFSFyqgdMDAVCAFESRLYTvsmVFLCL 294
Cdd:cd15330  177 VLYGRIFK--------AAARERKTVKTLGIIMGTFILCWLPFFIVALV----LPF----CESTCHMPELLGA---IINWL 237
                        250
                 ....*....|..
gi 568980130 295 STVNSVADPIIY 306
Cdd:cd15330  238 GYSNSLLNPIIY 249
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
46-257 2.49e-06

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 48.64  E-value: 2.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLtLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQnQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd14994    8 YSVVLIGGVIGVILMSFL-LVKMNTRSVTTTAVINLIVVHSLFLLTVPFRIYYYA-SKTWKFGMPLCKMVSAMIHIHMHL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF--------DMKVEKSFCFEPLRMNSKIAGY 197
Cdd:cd14994   86 TFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVPVFvkeygsssSYNSDQCFKFHKELEVHYVKVL 165
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568980130 198 HYLRFTFGFAIPLGILAFTNHQIFRSI-KLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYH 257
Cdd:cd14994  166 NYIIICIVLIVTLALLGFQVFILGHVYrKLRASLLSHQEFWAQMKSLFFIVVIIVCFVPYN 226
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-306 2.77e-06

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 48.30  E-value: 2.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd16004    7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRgHRHQRTAVTISACVILLVGLVN----YPVFDMKVEKSFCFE--PLRMNSK-IAGYH 198
Cdd:cd16004   87 SIYSMTAIAADRYMAIIHPFKPR-LSAGSTKVVIAGIWLVALALAFpqcfYSTVTMDQGRTKCIVawPGDSGGKhQLTYH 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 199 YLRFTFGFAIPLGILAFTNHQIFRSIKLS----DSLSAA------QKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFS 268
Cdd:cd16004  166 LAVIVLIYLLPLAVMFVTYSIIGITLWRSavpgHQAHGAyhrqlqAKKKFVKTMVVVVVTFAICWLPYHLYFILGSFNED 245
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568980130 269 FYQgdmdavcafESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd16004  246 IYC---------QKYIQQVYLAIFWLAMSSTMYNPIIY 274
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
77-308 3.53e-06

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 47.90  E-value: 3.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  77 YLFCLSLCEL-LYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRT 155
Cdd:cd15301   38 FLFSLAVADFaIGVISMPLFTVYTALGY-WPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKK 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 156 AVTISAC--VILLV----GLVNYPVFDMK--VEKSFCF-EPLRMNskiagyHYLrfTFG-----FAIPLGILAFTNHQIF 221
Cdd:cd15301  117 AAVMIASawIISLLlwppWIYSWPYIEGKrtVPAGTCYiQFLETN------PYV--TFGtalaaFYVPVTIMCILYWRIW 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 222 RSIKlsdSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAAsFSFYQgdmdavcAFESRLYTVSMvFLCLstVNSVA 301
Cdd:cd15301  189 RETK---KRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAF-FPCSD-------TIPTELWDFSY-YLCY--INSTI 254

                 ....*..
gi 568980130 302 DPIIYVL 308
Cdd:cd15301  255 NPLCYAL 261
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
75-226 3.59e-06

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 48.41  E-value: 3.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  75 AVYLFCLSLCELLYISTV---PLWIIYIQNQHKWNLGPQACKVTAY--IFFCniYISILLLCCISCDRYMAVVYalesrg 149
Cdd:cd15217   34 APYYFLLDLCLADTIRSAvcfPFVLVSIRNGSAWTYSVLSCKIVAFmaVLFC--FHAAFMLFCISVTRYMAIAH------ 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 150 HRHQRTAVTISACV-------ILLVGLVNYPVFDMKVEKSFCFEplrmNSKIAGYHYLRF--TFGFAIPLGILAFTNHQI 220
Cdd:cd15217  106 HRFYSKRMTFWTCIavicmvwTLSVAMAFPPVFDVGTYKFIREE----DQCIFEHRYFKAndTLGFMLMLAVLIVATHIV 181

                 ....*.
gi 568980130 221 FRSIKL 226
Cdd:cd15217  182 YGKLLL 187
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
46-278 3.75e-06

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 48.10  E-value: 3.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYIS-TVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15389    7 YSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLlNTPFTLVRFVNST-WVFGKIMCHLSRFAQYCSVY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRgHRHQRTAVTIsACVILLVGLVNYP--VFDMKVEKSFCFEPLRM-------NSKIA 195
Cdd:cd15389   86 VSTLTLTAIALDRHRVILHPLKPR-ITPCQGVVVI-AIIWIMASCLSLPhaIYQKLVEFEYSNERTRSrclpsfpEPSDL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 196 GYHYL---RFTFGFAIPLGILAFTNHQIFRSIKLSDSLSA-------AQKNKVKRSA---IAVVTIFLVCFAP---YHVV 259
Cdd:cd15389  164 FWKYLdlaTFILQYVLPLLIIGVAYTRVAKKLWLRNAIGDvtteqyvAQRRKKKKTIkmlMLVVLLFAICWLPlncYHVL 243
                        250       260
                 ....*....|....*....|....*
gi 568980130 260 LLVK------AASFSFYQGDMDAVC 278
Cdd:cd15389  244 LSSHpirsnsALFFAFHWLAMSSTC 268
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
105-308 3.92e-06

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 47.93  E-value: 3.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 105 WNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALesrghrHQRTAVTIS-ACVILLVG-----LVNYPV---- 174
Cdd:cd15055   66 WYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPL------LYPTKITIRrVKICICLCwfvsaLYSSVLlydn 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 175 --FDMKVEKSFCF-EPLRMNSKIAGYHYLRFTFGFAIPLGILAFTNhqIF----------RSIKLSDSLSAAQKNKVKRS 241
Cdd:cd15055  140 lnQPGLIRYNSCYgECVVVVNFIWGVVDLVLTFILPCTVMIVLYMR--IFvvarsqaraiRSHTAQVSLEGSSKKVSKKS 217
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568980130 242 AI-------AVVTIFLVCFAPYHVVLLVKaasfsfyqgdmdavcAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15055  218 ERkaaktlgIVVGVFLLCWLPYYIVSLVD---------------PYISTPSSVFDVLIWLGYFNSCLNPLIYAL 276
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
103-259 5.80e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 47.27  E-value: 5.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 103 HKWNLGPQACKVTAY-IFFCNIyISILLLCCISCDRYMAVVYalESRGHRHQRTAVTISACVILLVGLV--NYPVFDMKv 179
Cdd:cd15074   64 HRWLFGDIGCVFYGFcGFLFGC-CSINTLTAISIYRYLKICH--PPYGPKLSRRHVCIVIVAIWLYALFwaVAPLVGWG- 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 180 ekSFCFEPLRMNSKIAGYHYLR-----------FTFGFAIPLGIL-------AFTNHQIFRSIKLSDSLSAAQKN---KV 238
Cdd:cd15074  140 --SYGPEPFGTSCSIDWTGASAsvggmsyiisiFIFCYLLPVLIIvfsyvkiIRKVKSSRKRVAGFDSRSKRQHKierKV 217
                        170       180
                 ....*....|....*....|.
gi 568980130 239 KRSAIAVVTIFLVCFAPYHVV 259
Cdd:cd15074  218 TKVAVLICAGFLIAWTPYAVV 238
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
71-306 7.58e-06

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 46.81  E-value: 7.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  71 RNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGH 150
Cdd:cd15325   32 QTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISIDRYIGVSYPLRYPSI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 151 RHQRTAVTISACVILLVGLVNY-PVFDMKveksfcfEPLRMNSKIA------GYHYLRFTFGFAIPLGILAFTNHQIFRS 223
Cdd:cd15325  112 MTERRGLLALLCVWVLSLVISIgPLFGWK-------EPAPEDETICqiteepGYALFSALGSFYLPLAIILVMYCRVYVV 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 224 iklsdSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDmdavcafesrlyTVSMVFLCLSTVNSVADP 303
Cdd:cd15325  185 -----ALKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAYKPSD------------TVFKITFWLGYFNSCINP 247

                 ...
gi 568980130 304 IIY 306
Cdd:cd15325  248 IIY 250
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
86-315 8.76e-06

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 46.71  E-value: 8.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  86 LLYISTVPLWIIYIQNqHKWNLGPQACKV--TAYIFFCNIyiSILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACV 163
Cdd:cd15333   52 LVSILVMPISIVYTVT-GTWTLGQVVCDIwlSSDITCCTA--SILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALV 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 164 -ILLVGLVNYPVFDMKVEKSFCFEPLRMNSKIAGYhYLRFTFG-FAIPLGILAFTNHQIFRSIKlsdslsaAQKNKVKRS 241
Cdd:cd15333  129 wVISISISLPPFFWRQAKAEEEVSECVVNTDHILY-TVYSTVGaFYIPTLLLIALYGRIYVEAR-------ARERKATKT 200
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568980130 242 AIAVVTIFLVCFAPYHVVLLVKAASFSFyqgdmdavCAFESRLYTvsmVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15333  201 LGIILGAFIVCWLPFFIISLVLPICKDA--------CWFHLAIFD---FFTWLGYLNSLINPIIYTMSNEDFKQ 263
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
48-314 1.02e-05

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 46.67  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  48 AVCLLGLPANCLTAWLTLLQVlQRNVLAVYLFCLSLCELLYI--STVPLWIIYIQNQHKWNLGPQACKVTAYIFFCniyI 125
Cdd:cd15108    9 FTCVCGMAGNGLVVWLLSCRG-RRTPFCVYVLHLAVADLLFLlcMASTLSLETSPLVITHDLAYEVVRRVKYFAYT---A 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP--VFDMKVEKSFCFEPLRMNSKIAGyhylrFT 203
Cdd:cd15108   85 SLSLLTAISTQRCLSVLFPIWYKCHQPRHLSAVVCALLWALSLLMNVLasFFCSEFWHPDEWQCFKVDMVFSF-----LI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 204 FGFAIPlgILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVkaASFSFYQGDMDAVCAFESR 283
Cdd:cd15108  160 MGIFTP--VMALSSLILFVRVRRSSRQWRRRPTRLYVVVLASVLVFLACALPLGIYWFL--LYWLDLPQEVKTLFSCLSR 235
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568980130 284 LYtvsmvflclSTVNSVADPIIYVL-GTDHSR 314
Cdd:cd15108  236 LS---------SSVSSSANPVIYFLvGSRGSR 258
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
75-308 1.34e-05

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 46.10  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  75 AVYLFC-LSLCELLY-ISTVPLWIIYIQNQhKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALE-SRGHR 151
Cdd:cd15334   35 ANYLICsLAVTDFLVaVLVMPFSIMYIVKE-TWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEyARKRT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 152 HQRTAVTISACVILLVGLVNYPVFDMKVEKSfcfeplRMNSKIAGYHYLRF----TFG-FAIPLGILAFTNHQIFRsikl 226
Cdd:cd15334  114 PKHAGIMIAVVWIISIFISMPPLFWRHQTTS------REDECIIKHDHIVFtiysTFGaFYIPLALILILYYKIYR---- 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 227 sdslSAAQKNKVKRSAIAVVTIFLVCFAPYHVV-LLVKAASFSFYQGDMDAVCAFesrlytvsmvflcLSTVNSVADPII 305
Cdd:cd15334  184 ----AATRERKAATTLGLILGAFVICWLPFFVKeVIVNTCDSCYISEEMSNFLTW-------------LGYINSLINPLI 246

                 ...
gi 568980130 306 YVL 308
Cdd:cd15334  247 YTI 249
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
49-221 1.39e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 46.68  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  49 VCLLGLPANCLTAWLTLL-QVLQRnvlAVYLFCLSLC---ELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15005   10 ILCVSLAGNLLFSVLIVRdRSLHR---APYYFLLDLCladGLRSLACFPFVMASVRHGSGWIYGALSCKVIAFLAVLFCF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYalesrgHRHQRTAVTISACVIL------LVGLVNY-PVFDMkveKSFCFEPlRMNSKIAGY 197
Cdd:cd15005   87 HSAFTLFCIAVTRYMAIAH------HRFYAKRMTFWTCLAVicmawtLSVAMAFpPVFDV---GTYTFIR-EEDQCTFEH 156
                        170       180
                 ....*....|....*....|....*.
gi 568980130 198 HYLRF--TFGFAIPLGILAFTNHQIF 221
Cdd:cd15005  157 RSYKAndTLGFMLVLAVVIAATHLVY 182
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
93-306 2.19e-05

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 45.42  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  93 PLWIIYIQNQHkWNLGPQackvtayifFCNIYISILLLCC---------ISCDRYMAVVYALESRGHRHQRTAVTISACV 163
Cdd:cd15331   55 PLSAVYEVSQH-WFLGPE---------VCDMWISMDVLCCtasilhlvaIALDRYWAVTNIDYIRRRTAKRILIMIAVVW 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 164 ILLVGLVNYPVFDMKvEKSFCFEPLR----MNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRsiklsdslsAAQKNKVK 239
Cdd:cd15331  125 FVSLIISIAPLFGWK-DEDDLDRVLKtgvcLISQDYGYTIFSTVGAFYVPLLLMIIIYWKIYQ---------AAKRERKA 194
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568980130 240 RSAIAVVT-IFLVCFAPYHVVLLVKaasfsfyqgdmdAVCAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15331  195 ARTLAIITgAFVVCWLPFFLVALVM------------PFCGAWQISRFLESFFLWLGYFNSLLNPIIY 250
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
102-262 2.35e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 45.77  E-value: 2.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 102 QHKWNLGPQACKVtaYIFFCNIY--ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVF---- 175
Cdd:cd15337   64 NKKWIWGKVACEL--YGFAGGIFgfMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFfgwg 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 176 ---DMKVEKSFCFEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIK-------------LSDSLSAAQKNK-- 237
Cdd:cd15337  142 ryvPEGFQTSCTFDYLSRDLNNRLFILGLFIFGFLCPLLIIIFCYVNIIRAVRnhekemtqtaksgMGKDTEKNDARKka 221
                        170       180
                 ....*....|....*....|....*...
gi 568980130 238 ---VKRSAIAVVTIFLVCFAPYHVVLLV 262
Cdd:cd15337  222 eirIAKVAIILISLFLLSWTPYAVVALL 249
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
71-306 2.46e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 45.29  E-value: 2.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  71 RNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGH 150
Cdd:cd15327   32 QTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISVDRYVGVKHSLKYPTI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 151 RHQRTAVTISACVILLVGLVNY-PVFDMK----VEKSFCfeplrMNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSik 225
Cdd:cd15327  112 MTERKAGVILVLLWVSSMVISIgPLLGWKepppPDESIC-----SITEEPGYALFSSLFSFYLPLMVILVMYFRVYVV-- 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 226 lsdSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDMdavcafesrlytVSMVFLCLSTVNSVADPII 305
Cdd:cd15327  185 ---ALKFSREKKAAKTLAIVVGVFILCWFPFFFVLPLGSFFPALKPSEM------------VFKVIFWLGYFNSCVNPII 249

                 .
gi 568980130 306 Y 306
Cdd:cd15327  250 Y 250
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
47-306 3.40e-05

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 44.79  E-value: 3.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  47 SAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYIS 126
Cdd:cd15062    8 GAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 127 ILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNY-PVFDMKVEKSFCFEPLRMNSKiAGYHYLRFTFG 205
Cdd:cd15062   88 IMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIgPLLGWKEPAPADEQACGVNEE-PGYVLFSSLGS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 206 FAIPLGILAFTNHQIFRSiklsdSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKaasfsfyqgdmdavcAFESRLY 285
Cdd:cd15062  167 FYLPLAIILVMYCRVYVV-----AFKFSREKKAAKTLGIVVGAFVLCWFPFFVVLPLG---------------SLFSTLK 226
                        250       260
                 ....*....|....*....|....
gi 568980130 286 TVSMVFLC---LSTVNSVADPIIY 306
Cdd:cd15062  227 PPEPVFKVvfwLGYFNSCLNPIIY 250
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
122-306 3.90e-05

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 44.82  E-value: 3.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 122 NIYISILLLCCISCDRYMAVVYALES---RGHRHQRTAVTISACVILLVGLVNYPVFDMKV--EKSFCFEPLRMnskiag 196
Cdd:cd14989   81 NMYSSIFFLTWMSFDRYIALAKVMKSsplRTMQHARLSCGLIWMASISATLLPFTAVQAQHtgEVHFCFADVRE------ 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 197 YHYLRFTFGFAIPLGILAFTNHQIFRsiklsdSLSAAQKN--------KVKRSAIAVVTIFLVCFAPYHVVLlvkaaSFS 268
Cdd:cd14989  155 IQWLEVTLGFIIPFSIIGLCYSLIVR------VLVRAQKHrrlrprrqKALRMILVVVLVFFICWLPENVFI-----SIQ 223
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 568980130 269 FYQGDMDAVCAFESRL---YTVSMVFLCLSTV-NSVADPIIY 306
Cdd:cd14989  224 LLQGTQEPSESYDESFrhnHPLTGHIVNLAAFsNSCLNPLIY 265
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
49-308 4.12e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 44.92  E-value: 4.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  49 VCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCE-LLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISI 127
Cdd:cd15304   10 VIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADmLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 128 LLLCCISCDRYMAVVYAL-ESRGHRHQRTAVTISACVILLVGL-VNYPVFDMKvEKSFCFEPLRMNSKIAGYHYLRFTFG 205
Cdd:cd15304   90 MHLCAISLDRYIAIRNPIhHSRFNSRTKAFLKIIAVWTISVGIsMPIPVFGLQ-DDSKVFKEGSCLLADENFVLIGSFVA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 206 FAIPLGILAFTNHQIFRSIKLSDSlsaaQKNKVKRSAIAVVTIFLVCFAPYhvvllvkaasfsFYQGDMDAVC---AFES 282
Cdd:cd15304  169 FFIPLTIMVITYFLTIKSLQQSIS----NEQKASKVLGIVFFLFVVMWCPF------------FITNVMAVICkesCNEV 232
                        250       260
                 ....*....|....*....|....*.
gi 568980130 283 RLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15304  233 VIGGLLNVFVWIGYLSSAVNPLVYTL 258
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
47-317 4.39e-05

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 44.53  E-value: 4.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  47 SAVCLLGLPANC--LTAWLTLLQVLQRnvlaVYLFCLSLC--ELL--YISTVPLWIIYIQNQHkwnLGPQA-CKVTAYIF 119
Cdd:cd15196    8 ATILVLALFGNScvLLVLYRRRRKLSR----MHLFILHLSvaDLLvaLFNVLPQLIWDITYRF---YGGDLlCRLVKYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 120 FCNIYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISA--CVILLVGLVNYPVFDMKVEKS---FCFEPLRMNSKI 194
Cdd:cd15196   81 VVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIawVLSLLLSIPQLFIFSYQEVGSgvyDCWATFEPPWGL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 195 AGYHYLRFTFGFAIPLGILAFTNHQIFRSIKlsdslsAAQKNKVKRSaIAVVTIFLVCFAPYHVVLLVKAasfsfyqgdM 274
Cdd:cd15196  161 RAYITWFTVAVFVVPLIILAFCYGRICYVVW------RAKIKTVKLT-LVVVACYIVCWTPFFVVQMWAA---------W 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568980130 275 DAVCAFESRLYTVSMVFLCLstvNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15196  225 DPTAPIEGPAFVIIMLLASL---NSCTNPWIYLAFSGNLRRAL 264
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
46-268 4.85e-05

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 44.51  E-value: 4.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANcltawLTLLQVL-----QRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFF 120
Cdd:cd15124    7 YGIIILIGLIGN-----ITLIKIFctvksMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 121 CNIYISILLLCCISCDRYMAVVYALESRGHrHQRTAVTISACVILLVGLV----------NYPVFDMKVEKSF--CFEPL 188
Cdd:cd15124   82 TSVGVSVFTLTALSADRYKAIVRPMDIQAS-NALMKICLKAALIWILSMLlaipeavfsdLHPFYDKSTNKTFvsCAPYP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 189 RMNSKIAGYHYL-RFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKN-----------KVKRSAIAVVTIFLVCFAPY 256
Cdd:cd15124  161 HSNELHPKIHSMaSFLIFYVIPLSIISVYYYFIAKNLIRSAYNLPVEGNvhvrrqiesrkRLAKTVLVFVGLFAFCWLPN 240
                        250
                 ....*....|..
gi 568980130 257 HVVLLVKAASFS 268
Cdd:cd15124  241 HIIYLYRSYHYS 252
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
105-306 4.94e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 44.54  E-value: 4.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 105 WNLGPQACKV--TAYIFFCNIyiSILLLCCISCDRYMAVVYALESRGHRHQRTAV---TISACVILLVGLVnYPVFDMKV 179
Cdd:cd15314   66 WYFGDLFCKIhsSFDITLCTA--SILNLCFISIDRYYAVCQPLLYRSKITVRVVLvmiLISWSVSALVGFG-IIFLELNI 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 180 EKSF-----CFEP-LRMNSKIAGYHYlrFTFGFAIPLGILAFTNHQIF-------RSIKLSDSLSAAQKNKVKRSA---I 243
Cdd:cd15314  143 KGIYynhvaCEGGcLVFFSKVSSVVG--SVFSFYIPAVIMLCIYLKIFlvaqrqaRSIQSARTKSGASSSKMERKAtktL 220
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568980130 244 AVVT-IFLVCFAPYHVVLLVKaaSFSFYQgdmDAVCAFEsrlytvsmVFLCLSTVNSVADPIIY 306
Cdd:cd15314  221 AIVMgVFLLCWTPFFLCNIID--PFINYS---IPPVLIE--------VLNWLGYSNSTLNPFIY 271
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
49-306 5.21e-05

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 44.44  E-value: 5.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  49 VCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCE-LLYISTVPLWIIYIqNQHKWNLGPQACKVTAYIFFCNIYISI 127
Cdd:cd15404   10 ILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADmMLAVLNMPFALVTI-ITTRWIFGDAFCRVSAMFFWLFVMEGV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 128 LLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGL---VNYPVFDMKVEKSFCFEPLRMNSKIAGYHYLRFTF 204
Cdd:cd15404   89 AILLIISIDRFLIIVQKQDKLNPYRAKVLIAVSWAVSFCVAFplaVGSPDLQIPSRAPQCVFGYTTNPGYQAYVILIMLI 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 205 GFAIPLGILAFTNHQIFRSIKlsdslsaAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQgdmdavcafESRL 284
Cdd:cd15404  169 FFFIPFMVMLYSFMGILNTVR-------SFKTRAFTTILILFIVFTVCWAPFTTYSLVATFNSHFYH---------KHNF 232
                        250       260
                 ....*....|....*....|..
gi 568980130 285 YTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15404  233 FEISTWLLWLCYLKSALNPLIY 254
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
75-306 1.02e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 43.37  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  75 AVYLFC-LSLCELLY-ISTVPLWIIYIQNQhKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALE-SRGHR 151
Cdd:cd15335   35 ANYLICsLAVTDFLVaVLVMPLSITYIVMD-TWTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEyARKRT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 152 HQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRsiklsdslS 231
Cdd:cd15335  114 AKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCIIQHDHVIYTIYSTFGAFYIPLTLILILYYRIYH--------A 185
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568980130 232 AAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASfsfyqgdmdaVCAFESRlytVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15335  186 ASRERKAARILGLILGAFILSWLPFFIKELIVGLS----------VMTVSPE---VADFLTWLGYVNSLVNPLLY 247
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
118-306 1.11e-04

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 43.48  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 118 IFFCNIyiSILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRMN--SKIA 195
Cdd:cd15059   81 VLFCTA--SIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPWHGAEPQCelSDDP 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 196 GYHYLRFTFGFAIPLGILAFTNHQIFRsiklsdslsaAQKNKVKRSA--IAVV-TIFLVCFAPYHVVLLVKaasfsfyqg 272
Cdd:cd15059  159 GYVLFSSIGSFYIPLLIMIIVYARIYR----------AAKRKERRFTlvLGVVmGAFVLCWLPFFFTYPLV--------- 219
                        170       180       190
                 ....*....|....*....|....*....|....
gi 568980130 273 dmdAVCAFESRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15059  220 ---VVCKTCGVPELLFKFFFWLGYCNSALNPVIY 250
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
111-308 1.39e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 43.00  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 111 ACKVTAYIFF----CNIYI---------SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP---V 174
Cdd:cd15323   59 ANELMGYWYFgqvwCNIYLaldvlfctsSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPpliS 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 175 FDMKVEKSfCFEPLRMNSKIagYHYLRFTFG-FAIPLGILAFTNHQIFRSIKlsdslsaAQKNKVKRSAIAVVTIFLVCF 253
Cdd:cd15323  139 MYRDPEGD-VYPQCKLNDET--WYILSSCIGsFFAPCLIMILVYIRIYRVAK-------AREKRFTFVLAVVMGVFVVCW 208
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568980130 254 APYHVvllvkaaSFSFYqGDMDAVCAFESRLYTvsmVFLCLSTVNSVADPIIYVL 308
Cdd:cd15323  209 FPFFF-------SYSLY-GICREACEVPEPLFK---FFFWIGYCNSSLNPVIYTI 252
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
81-306 1.59e-04

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 43.03  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  81 LSLCELLYISTVPLWIIYIQ-NQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALE---SRGHRHQRTA 156
Cdd:cd15310   42 LAVADLLVATLVMPWVVYLEvTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHyqhGTGQSSCRRV 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 157 VTISACVILLVGLVNYPV---FDMKVEKSFCfeplrmnsKIAGYHYLRFT--FGFAIPLGILAFTNHQIFrsiklsdsLS 231
Cdd:cd15310  122 SLMITAVWVLAFAVSCPLlfgFNTTGDPTVC--------SISNPDFVIYSsvVSFYLPFGVTLLVYVRIY--------VV 185
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568980130 232 AAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASfsfyqgdmdAVCAFESRLYTvsmVFLCLSTVNSVADPIIY 306
Cdd:cd15310  186 LLREKKATQMLAIVLGAFIVCWLPFFLTHILNTHC---------QACHVPPELYS---ATTWLGYVNSALNPVIY 248
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
46-262 2.12e-04

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 42.88  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15395    7 YSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMtIMCLPFTFVYTLMDH-WVFGEAMCKLNSMVQCISIT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVvyaLESRGHR--HQRTAVTISACVILLVG---------------LVNYPV-FDMKVEKSFCFE 186
Cdd:cd15395   86 VSIFSLVLIAIERHQLI---INPRGWRpnNRHAYVGIAVIWVLAVLtslpflifqvltdepFKNVNVsLDAYKGKYVCLD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 187 PLRMNSKIAGYHYLRFTFGFAIPLGILAFTNHQIF-RSIKLSDSLSAAQKNKVKRSA--------IAVVTIFLVCFAPYH 257
Cdd:cd15395  163 QFPSDTIRLSYTTCLLVLQYFGPLCFIFICYLKIYiRLKRRNNMMDKMRDNKYRSSEtkrinimlISIVVAFAVCWLPLN 242

                 ....*
gi 568980130 258 VVLLV 262
Cdd:cd15395  243 IFNAV 247
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
51-308 2.15e-04

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 42.51  E-value: 2.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  51 LLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLL 130
Cdd:cd15077   12 IAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSLWSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 131 CCISCDRYMAVVYALesrGHRHQRTAVTISACVILLV-GLVNY--PVFDMK------VEKSFCFEPLRMNSKIAGYHYLR 201
Cdd:cd15077   92 AVVAFERFLVICKPL---GNFTFRGTHAIIGCIATWVfGLAASlpPLFGWSryipegLQCSCGPDWYTTNNKWNNESYVM 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 202 F--TFGFAIPLGILAFTNHQIFRSIKL-------SDSLSAAQKnKVKRSAIAVVTIFLVCFAPYhvvllvkaASFS---- 268
Cdd:cd15077  169 FlfCFCFGVPLSIIVFSYGRLLLTLRAvakqqeqSASTQKAER-EVTKMVVVMVLGFLVCWLPY--------ASFAlwvv 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568980130 269 FYQGDmdavcAFESRLYTVSMVFlclSTVNSVADPIIYVL 308
Cdd:cd15077  240 TNRGE-----PFDLRLASIPSVF---SKASTVYNPVIYVF 271
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
69-308 2.49e-04

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 42.44  E-value: 2.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  69 LQRNVLAVYLFCLSLCELLY-ISTVPLWIIYIQNQHKwNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALES 147
Cdd:cd15219   30 LRKQVPGIFLLNLSFCNLLLtVLNMPFTLLGVVRNRQ-PFGDGFCQAVGFLETFLTSNAMLSMAALSIDRWIAVVFPLSY 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 148 RGHRHQRTAVTISAC----------VILLVGLVNYPvfDMKVEKSFCFEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTN 217
Cdd:cd15219  109 TSKMRYRDAALMVGYswlhsltfslVALFLSWLGYS--SLYASCTLHLPREEERRRFAVFTAFFHAFTFLLSLLVLCVTY 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 218 HQIFRSIKlsdslsaaQKNKVKRSAIAVVTiFLVCFAPYHVVLLVKAASF---SFYQGdmdavcafesrlytvsMVFLCL 294
Cdd:cd15219  187 LKVLKVRR--------RQRATKKISIFIGT-FVLCFAPYVITRLVELLPFvtiNRYWG----------------IVSKCL 241
                        250
                 ....*....|....
gi 568980130 295 STVNSVADPIIYVL 308
Cdd:cd15219  242 TYSKAASDPFVYSL 255
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
125-309 2.64e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 42.24  E-value: 2.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTA-VTISACVIL--LVGLVnyPVF---DMKVEKSFCFEPLRM---NSKIA 195
Cdd:cd14968   84 SSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAwGAIAVCWVLsfLVGLT--PMFgwnNGAPLESGCGEGGIQclfEEVIP 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 196 GYHYLRFTFgFA---IPLGILAFTNHQIFRSIK-----------LSDSLSAAQKN-KVKRSAIAVVTIFLVCFAPYHVvl 260
Cdd:cd14968  162 MDYMVYFNF-FAcvlVPLLIMLVIYLRIFRVIRkqlrqiesllrSRRSRSTLQKEvKAAKSLAIILFLFALCWLPLHI-- 238
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568980130 261 lvkaasfsfyqgdMDAVCAFESRLYTVSMVFL---CLSTVNSVADPIIYVLG 309
Cdd:cd14968  239 -------------INCITLFCPECKVPKILTYiaiLLSHANSAVNPIVYAYR 277
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-308 2.74e-04

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 42.48  E-value: 2.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  47 SAVCLL----GLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCN 122
Cdd:cd15132    4 TIVCLIlfvvGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRPWIFGEFLCRLYHYISEGC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 123 IYISILLLCCISCDRYMAVVYALESR---GHRHQRTAVTISACVIL--------LVGLVNYPVFDMKVEKSFC-FEPLRM 190
Cdd:cd15132   84 TYATILHITALSIERYLAICFPLRAKvlvTRRRVKCVIAALWAFALlsagpflfLVGVEQDNNIHPDDFSRECkHTPYAV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 191 NSKIAGYHYLRFTFGFAIPLGILA----FTNHQIFRSIKLSDSLSAAQKNKVKRSAI----AVVTIFLVCFAPYHVVLLV 262
Cdd:cd15132  164 SSGLLGIMIWVTTTYFFLPMLCLSflygFIGRKLWKSKNDLRGPNAAARERSHRQTVrilaVVVLAFIICWLPFHIGRIL 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568980130 263 kaasfsFYQGDMDAVCAFESRLYTVSMVFLCLStvnSVADPIIYVL 308
Cdd:cd15132  244 ------FANTEDYRTMMFSQYFNIVAMQLFYLS---ASINPILYNL 280
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
77-308 2.97e-04

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 42.04  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  77 YLFCLSLCELLY-ISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRT 155
Cdd:cd15302   38 FIASLAVSDLLIgLESMPFYTVYVLNGDYWPLGWVLCDLWLSVDYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRK 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 156 AVTISACVILLVGLVNY--------------PVFDMKVEKSFCFEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTN--HQ 219
Cdd:cd15302  118 VLLIIAITWIIPALLFFisifgwqyftgqgrSLPEGECYVQFMTDPYFNMGMYIGYYWTTLIVMLILYAGIYRAANraRK 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 220 IFRSIKLsdslsaaqknkvkrsaiaVVTIFLVCFAPYHVVLLVKaasfsfyqGDMDAVCAFESRLYTVSMvFLCLstVNS 299
Cdd:cd15302  198 ALRTITF------------------ILGAFVICWTPYHILATIY--------GFCEAPPCVNETLYTISY-YLCY--MNS 248

                 ....*....
gi 568980130 300 VADPIIYVL 308
Cdd:cd15302  249 PINPFCYAL 257
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
71-264 3.29e-04

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 42.02  E-value: 3.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  71 RNVLAVYLFCLSLCELLYIST-VPLwIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESR- 148
Cdd:cd14977   32 RSVPNILIASLALGDLLLLLLcVPL-NAYNLLTKDWLFGDVMCKLVPFIQVTSLGVTVFSLCALSIDRYRAAVNSMPMQt 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 149 GHRHQRTAVTI----SACVILLV-GLVNYPVFDMKVEKSFCFE--PLRMNSKIAGYHY-----LRFTFGFAIPLGILAFT 216
Cdd:cd14977  111 IGACLSTCVKLaviwVGSVLLAVpEAVLSTVARESSLDNSSLTvcIMKPSTPFAETYPkarswWLFGCYFCLPLAFTAVC 190
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568980130 217 NHQIFRSI-------KLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKA 264
Cdd:cd14977  191 YLLMARTLiraakeyTRGTKKHMKQRRQLAKTVLCLVLVFAFCWLPEHISNILRA 245
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
71-306 3.41e-04

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 41.93  E-value: 3.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  71 RNVLAVYLFCLSLCELLYISTV-PLWIIYIQNQHkWNLGPqackvtayiFFCNIYISILLLCC---------ISCDRYMA 140
Cdd:cd15051   32 RNLTNYFIVSLAVTDLLLGLLVlPFSAIYELRGE-WPLGP---------VFCNIYISLDVMLCtasilnlfaISLDRYLA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 141 VVYALE-SRGHRHQRTAVTISA--CVILLVGLV---------NYPVFDMKVEKSFCFEPLRmnskiagYHYLRFTFG-FA 207
Cdd:cd15051  102 ITAPLRyPSRVTPRRVAIALAAiwVVSLAVSFLpihlgwntpDGRVQNGDTPNQCRFELNP-------PYVLLVAIGtFY 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 208 IPLGILAFTNHQIF--------RSIKLSDSLSAAQKN--KVKRSAIAVVTI------FLVCFAPYHVVLLVKaasfsfyq 271
Cdd:cd15051  175 LPLLIMCGVYLRIFriareqakRINALTPASTANSSKsaATAREHKATVTLaavlgaFIICWFPYFTYFTYR-------- 246
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568980130 272 gdmdAVCAFESRlYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15051  247 ----GLCGDNIN-ETALSVVLWLGYANSALNPILY 276
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
120-311 3.67e-04

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 42.03  E-value: 3.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 120 FCNIYI---------SILLLCCISCDRYMAVVYALESRGHRHQRTAV-------TISACVILL-VGLVNYPVFDMKVEKS 182
Cdd:cd15057   72 FCDVWVsfdimcstaSILNLCVISVDRYWAISSPFRYERRMTRRRAFimiavawTLSALISFIpVQLGWHRADDTSEALA 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 183 FCFEPLRMNSKIAGYHYLRFTF-GFAIPLGILAFTNHQIFRSIK--------LSDSLSAAQKN-KVKRSAIA-------- 244
Cdd:cd15057  152 LYADPCQCDSSLNRTYAISSSLiSFYIPVAIMIVTYTRIYRIARrqirriaaLERAAQESTNPdSSLRSSLRretkalkt 231
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 245 ---VVTIFLVCFAPYHVVLLVkaasFSFYQGDMDAVCAFESRLYTvsmVFLCLSTVNSVADPIIYVLGTD 311
Cdd:cd15057  232 lsiIMGVFVCCWLPFFILNCV----LPFCDLRTAQFPCVPDTTFI---VFVWLGWANSSLNPIIYAFNAD 294
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
105-313 4.10e-04

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 41.64  E-value: 4.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 105 WNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALE-SRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKS- 182
Cdd:cd15197   66 WRAGDFACKVIRYLQVVVTYASTYVLVALSIDRYDAICHPMNfSQSGRQARVLICVAWILSALFSIPMLIIFEKTGLSNg 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 183 --FCFEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSI------------------KLSDSLSAA--QKNKVK- 239
Cdd:cd15197  146 evQCWILWPEPWYWKVYMTIVAFLVFFIPATIISICYIIIVRTIwkkskiqvtinkaglhdgSSRRSSSRGiiPRAKIKt 225
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568980130 240 -RSAIAVVTIFLVCFAPYHVVLLVKAAsfsfyqGDMDavcafESR-LYTVSMVFLCLSTVNSVADPIIYVLGTDHS 313
Cdd:cd15197  226 iKMTFVIVTVFIICWSPYFVFDLLDVF------GLLP-----RSKtKIAAATFIQSLAPLNSAINPLIYCLFSTHL 290
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
94-317 4.52e-04

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 41.58  E-value: 4.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  94 LWIIYIQnqhkWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALES-----RGHRHQRTAVTISAcVILLVG 168
Cdd:cd15383   60 AWNVTVQ----WYAGDLACRLLMFLKLFAMYSSAFVTVVISLDRHAAILNPLAIgsarrRNRIMLCAAWGLSA-LLALPQ 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 169 LVNYPVFDMKVEKSF--C----FEPLRMNSKIagyhYLRFTFG--FAIPLGILAFTNHQIFRSI--KLSDSLSAAQKNKV 238
Cdd:cd15383  135 LFLFHTVTATPPVNFtqCathgSFPAHWQETL----YNMFTFFclFLLPLLIMIFCYTRILLEIsrRMKEKKDSAKNEVA 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 239 KRS---------------AIAVVTIFLVCFAPYHVVLLvkaasFSFYQGDMDAVCAFESrlytVSMVFLCLSTVNSVADP 303
Cdd:cd15383  211 LRSssdnipkarmrtlkmTIVIVSSFIVCWTPYYLLGL-----WYWFSPEMLEQTVPES----LSHILFLFGLLNACLDP 281
                        250
                 ....*....|....
gi 568980130 304 IIYVLGTDHSRQEV 317
Cdd:cd15383  282 LIYGLFTISFRRGL 295
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
46-261 4.60e-04

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 41.69  E-value: 4.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTA-WLTLLQVLQRNVLAVYLFCLSLCELLyistVPLWIIYI----QNQHKWNLGPQACKVTAYIF- 119
Cdd:cd15129    7 YSVLLCLGLPVNILTAvALSRLAVRTKKSSYYYLLALTASDIL----TQVFIIFVgfilQTAILAREVPHALIHTVSVLe 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 120 FCNIYISILLLCCISCDRYMAVVYALESRGHRH-QRTAVTISACVI--LLVGLVNYPVFDMKVEKSfcfEPLRMNSKIAG 196
Cdd:cd15129   83 FAANHASIWITVLLTVDRYVALCHPLRYRAVSYpERTRRIIAAVFVaaLATGIPFYWWSDMWRDSH---PPTTLDKVLKW 159
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568980130 197 YHYLRFTFgfaIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAI--AVVTIFLVCFAPYHVVLL 261
Cdd:cd15129  160 THCFIIYF---IPCTIFLVTNSVIIHKLRRRKGRSGPQRRSGKTTAIllAITTVFAVLWAPRTVVII 223
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
46-306 6.84e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 40.95  E-value: 6.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLWIIyIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15979    7 YSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLaVFCMPFTLI-PNLMGTFIFGEVICKAVAYLMGVSVS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGL--VNYPVFDMKVEKSFCFEPLRMNSKIA------- 195
Cdd:cd15979   86 VSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLimIPYPVYSVTVPVPVGDRPRGHQCRHAwpsaqvr 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 196 -GYHYLRFTFGFAIPLGILAFTNHQIFRsiKLSDSLSAaqKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAasfsfyqgdM 274
Cdd:cd15979  166 qAWYVLLLLILFFIPGVVMIVAYGLISR--ELYRGLLA--KKRVIRMLVVIVAMFFLCWLPIFSANTWRA---------F 232
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568980130 275 DAVCAFEsRLYTVSMVFL-CLSTVNSVADPIIY 306
Cdd:cd15979  233 DPLSAHR-ALSGAPISFIhLLSYTSACVNPLVY 264
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
64-305 7.21e-04

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 41.00  E-value: 7.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  64 TLLQVL-----QRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKW-----NLGPQACKVTAYIFFCNIYISILLLCCI 133
Cdd:cd15975   20 TLLRIIyqnkcMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWpfddsSFGVFLCKLVPFLQKASVGITVLNLCAL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 134 SCDRYMAVVYALESRGHRHQR-TAVTISACVIL--LVGLVNYPVFDM-------KVEKSFCFEPLR--MNSKIAGYHYLR 201
Cdd:cd15975  100 SVDRYRAVASWSRVQGIGIPLiTAIEIFSIWVLsfILAIPEAIGFVMvpfeyngEQYRTCMLNATTkfMNFYVDAKDWWL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 202 FTFGFAIPLGILAF--------TNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSfyqgD 273
Cdd:cd15975  180 FGFYFCVPLACTAIfytlmtceMLNRRKGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYN----E 255
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568980130 274 MD-AVCAFESRLYTVSMVFLCLSTVNSVADPII 305
Cdd:cd15975  256 NDpRRCELLSFLLVMDYISINLATMNSCINPIA 288
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
46-257 7.86e-04

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 40.76  E-value: 7.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQV-LQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15169    7 YVAAFALGFPLNVLAIRGATAHArLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFAPLY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALESRGHRHQR----TAVTISACVILLVGLV-------------------NYPVFDMKVek 181
Cdd:cd15169   87 AGGGFLAALSAGRYLGAAFPLGYQAFRRPCyswgVCAAIWALVLCHLGLVfgleapggwldhsntslgiNTPVNGSPV-- 164
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980130 182 sfCFEPLRMNSKIAGyhylRFTFG---FAIPLGILAFTNHQIFRSIKLSdSLSAAQKNKVKRSAIAVVTIFLVCFAPYH 257
Cdd:cd15169  165 --CLEAWDPASAGPA----RFSLSlllFFLPLAITAFCYVGCLRALARS-GLTHRRKLRAAWVAGGALLTLLLCVGPYN 236
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
46-306 9.18e-04

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 40.76  E-value: 9.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANcLTAWLTLLQVLQRNVLAVYLFCLSL------CELLYISTVPLWIIYIQnqhkWNLGPQACKVTAYIF 119
Cdd:cd15382    7 YSVLFLIAAVGN-LTVLLILLRNRRRKRSRVNILLMHLaiadllVTFIMMPLEIGWAATVA----WLAGDFLCRLMLFFR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 120 FCNIYISILLLCCISCDRYMAVVYALES-----RGHRHQRTAVTISA-CVI---LLVGLVNYPVFDMkVEKSFCFEPLRM 190
Cdd:cd15382   82 AFGLYLSSFVLVCISLDRYFAILKPLRLsdarrRGRIMLAVAWVISFlCSIpqsFIFHVESHPCVTW-FSQCVTFNFFPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 191 NSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSI------KLSDSLSAAQKNKVKRSA---------------IAVVTIF 249
Cdd:cd15382  161 HDHELAYNIFNMITMYALPLIIIVFCYSLILCEIsrkskeKKEDVSEKSSSVRLRRSSvgllerarsrtlkmtIVIVLVF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568980130 250 LVCFAPYHVVLLVkaasfsfYQGDMDAVCAFESRLYTVSMVFLCLstvNSVADPIIY 306
Cdd:cd15382  241 IICWTPYFIMSLW-------YWFDRESASKVDPRIQKGLFLFAVS---NSCMNPIVY 287
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
47-306 9.94e-04

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 40.64  E-value: 9.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  47 SAVCLLGLPANCLTAWLTLLQVLQ----RNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCN 122
Cdd:cd15131    4 TVTCVLLFVVGVTGNLMTMLVVSKyrdmRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 123 IYISILLLCCISCDRYMAVVYALESRGHRHQRTaVTISACVILLVGLVNY-PVFDM-KVEKSFCFEPLRMNSKIAGYHYL 200
Cdd:cd15131   84 TYSTILNITALSVERYFAICFPLRAKVVVTKRR-VKLVILVLWAVSFLSAgPIFVLvGVEHENGTNPIDTNECKATEYAV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 201 R-------------FTFGFAIPLGIL-AFTNHQIFRSIKLSDSLSAAQKNKVKRSAI----AVVTIFLVCFAPYHVVLLV 262
Cdd:cd15131  163 RsglltimvwvssvFFFLPVFCLTVLySLIGRKLWRRRRENIGPNASHRDKNNRQTVkmlaVVVFAFVLCWLPFHVGRYL 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568980130 263 KAASFsfyQGDMDAVCAFESRLYTVSMVFLCLStvnSVADPIIY 306
Cdd:cd15131  243 FSKSF---EAGSLEIALISQYCNLVSFVLFYLS---AAINPILY 280
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
72-261 1.09e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 40.59  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  72 NVLAVYLFCLSLceLLYISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHR 151
Cdd:cd15008   35 NYFVVSMACADL--LLSVASAPFVLLQFTSGR-WTLGSAMCKLVRYFQYLTPGVQIYVLLSICVDRFYTIVYPLSFKVSR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 152 hQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRMNS-KIAGYHYLRFTFGFAIPLGILAFTNHQIFRSI------ 224
Cdd:cd15008  112 -EKAKKMIAASWLFDAAFVSPALFFYGSNWGPHCNFFLPDSwDGAAYAIIHLLVGFLVPSILIILFYQKVIKYIwrigtd 190
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 568980130 225 --KLSDSLSAAQKNKVK--RSAIAVVTIFLVCFAPYHVVLL 261
Cdd:cd15008  191 grTVRRTMNIVPRTKVKtiKMFLMLNSMFLLSWLPFYVVQL 231
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
86-306 1.21e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 40.20  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  86 LLYISTVPLWIIYIQNQHKWNLGPQACKV--TAYIFFCNIyiSILLLCCISCDRYMAVVYALE-SRGHRHQRTAVTISAC 162
Cdd:cd15308   48 LLALLVLPLYVYSEFQGGVWTLSPVLCDAlmTMDVMLCTA--SIFNLCAISVDRFIAVSVPLNyNRRQGSVRQLLLISAT 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 163 VILLVGLVNYPVFDMK----VEKSFCfeplrmnsKIAGYHYLRFT--FGFAIPLGILAFTNHQIFRSIklsdslsaAQKN 236
Cdd:cd15308  126 WILSFAVASPVIFGLNnvpnRDPAVC--------KLEDNNYVVYSsvCSFFIPCPVMLVLYCAMFRGL--------GRER 189
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 237 KVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDmdavcafesrlyTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15308  190 KAMRVLPVVVGAFLFCWTPFFVVHITRALCESCSIPP------------QLISIVTWLGYVNSALNPVIY 247
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
46-308 1.24e-03

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 40.52  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYIST-VPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIY 124
Cdd:cd15358    7 YLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLgMPLELYEMWSNYPFLLGAGGCYFKTLLFETVCF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 125 ISILLLCCISCDRYMAVVYALE-----SRGHRhQRTAVTISACVIL-------LVGLVNYPVFDMKV--EKSFC--FEPL 188
Cdd:cd15358   87 ASILNVTALSVERYIAVVHPLKakyvvTRTHA-KRVIGAVWVVSILcsipntsLHGIFQLTVPCRGPvpDSATCmlVKPR 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 189 RMNSKIAGYHYLRFtfgFAIPLGILAFTNHQI---FRSIKLSDSLSAA-------------QKNKVKRSAI-----AVVT 247
Cdd:cd15358  166 WMYNLIIQITTLLF---FFLPMGTISVLYLLIglqLKREKMLLVLEAKgskagdsyqhrriQQEKRRRRQVtkmlfVLVV 242
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568980130 248 IFLVCFAPYHVVLLVkaasFSFYQGDMDAVCAFESRLYTVSMVFLCLStvnSVADPIIYVL 308
Cdd:cd15358  243 VFGICWAPFHTDRLM----WSFISQWTGELHLAFQYVHIISGVFFYLS---SAANPVLYNL 296
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
81-306 1.29e-03

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 40.02  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  81 LSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYAL--ESRGHRHQRTAVT 158
Cdd:cd15309   42 LAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMlyNTRYSSKRRVTVM 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 159 ISACVILLVGLVNYPVFDM-KVEKSFCFeplrmnskIAGYHYLRFT--FGFAIPLGILAFTNHQIFRSIklsdslsaaQK 235
Cdd:cd15309  122 ISVVWVLSFAISCPLLFGLnNTDQNECI--------IANPAFVVYSsiVSFYVPFIVTLLVYVQIYIVL---------QK 184
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568980130 236 NKVKRSAIAVVT-IFLVCFAPYHVVLLVkaasfsfyqgDMDAVCAFESRLYTvsmVFLCLSTVNSVADPIIY 306
Cdd:cd15309  185 EKKATQMLAIVLgVFIICWLPFFITHIL----------NMHCDCNIPPALYS---AFTWLGYVNSAVNPIIY 243
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
126-317 1.30e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 40.15  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSF--CFEPLRMNSKiagyHYLRF- 202
Cdd:cd15102   86 SVFSLLAIAIERHLTMAKMKPYGASKTSRVLLLIGACWLISLLLGGLPILGWNCLGALdaCSTVLPLYSK----HYVLFc 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 203 TFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVK-----RSAIAVVTIFLVCFAPYHVVLLvkaasfsfyqgdMDAV 277
Cdd:cd15102  162 VTIFAGILAAIVALYARIYCLVRASGRKATRASASPRslallKTVLIVLLVFIACWGPLFILLL------------LDVA 229
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 568980130 278 CAFESRLYTVSM-VFLCLSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15102  230 CPVKTCPILYKAdWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
105-303 1.61e-03

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 39.90  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 105 WNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYP--VFD-----M 177
Cdd:cd15123   66 WLFGRIGCKLLSFIQLTSVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPeaVFSdlysfR 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 178 KVEKSFCFE---PLRMNSKIAG--YHYLRFTFGFAIPLGILAFTNHQIFRSIKLS------DSLSAAQKN-----KVKRS 241
Cdd:cd15123  146 DPEKNTTFEacaPYPVSEKILQeiHSLLCFLVFYIIPLSIISVYYFLIARTLYKStfnmpaEEHSHARKQiesrkRVAKT 225
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568980130 242 AIAVVTIFLVCFAPYHVVLLVKaaSFSfYQGDMDAvcafeSRLYTVSMVF-LCLSTVNSVADP 303
Cdd:cd15123  226 VLVLVALFAFCWLPNHILYLYR--SFT-YHTSVDS-----SAFHLIATIFsRVLAFSNSCVNP 280
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
49-308 1.74e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 39.89  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  49 VCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISI 127
Cdd:cd15305   10 IIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVgILVMPVSLIAILYDYAWPLPRYLCPIWISLDVLFSTASI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 128 LLLCCISCDRYMAVVYALE-SRGHRHQRTAVTISACVILLVGL-VNYPVFDMK-VEKSFCFEPLRMNSKiaGYHYLRFTF 204
Cdd:cd15305   90 MHLCAISLDRYVAIRNPIEhSRFNSRTKAMMKIAAVWTISIGIsMPIPVIGLQdDEKVFVNGTCVLNDE--NFVLIGSFV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 205 GFAIPLGILAFTNHQIFRSIKLSDSLsaaqKNKVKRSAI--AVVTIFLVCFAPYhvvllvkaasfsFYQGDMDAVC---A 279
Cdd:cd15305  168 AFFIPLIIMVITYCLTIQVLQRQQAI----NNERRASKVlgIVFFLFLIMWCPF------------FITNILSVLCkeaC 231
                        250       260
                 ....*....|....*....|....*....
gi 568980130 280 FESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15305  232 DQKLMEELLNVFVWVGYVSSGINPLVYTL 260
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
49-306 1.80e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 39.72  E-value: 1.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  49 VCLLGLPANCLtawltLLQVLQRN-----VLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNI 123
Cdd:cd15000    9 VVLFGIFGNFV-----LLYILASNrslrtPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 124 YISILLLCCISCDRYMAVVYALESrghRHQRTAVTISACVILLVGLVNYPVFDMKVE----------KSFCFEplrmNSK 193
Cdd:cd15000   84 LASVLALCAVSYDRLTAIVLPSEA---RLTKRGAKIVIVITWIVGLLLALPLAIYRSyrerqwknflETYCAE----NTQ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 194 IAG-YHYLRFTFGFAIPLGILAFTNHQIF--------RSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKA 264
Cdd:cd15000  157 VLPiYWHVIITVLVWLPLGIMLICYSAIFwkldkyerRVLRREHPSVVRYKKKAAKTLFIVLITFVVCRIPFTALIFYRY 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568980130 265 ASFSfYQGDMDAVCAFESRLYTVSMVFLCLstvNSVADPIIY 306
Cdd:cd15000  237 KLVP-NDNTQNSVSGSFHILWFASKYLMFL---NAAVNPLIY 274
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
71-306 1.87e-03

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 39.78  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  71 RNVLAVYLFCLSLCELLY-ISTVPLWIIYIQNQHkWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVyalesRG 149
Cdd:cd15056   32 RKKTNYFVVSLAVADLLVaVLVMPFGAIELVNNR-WIYGETFCLVRTSLDVLLTTASIMHLCCIALDRYYAIC-----CQ 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 150 HRHQRtaVTISACVILLVGLVNYPVFD-----MKVEKSFCFEPLRMNSKIAGYHYLRF-----------TFGFAIPLGIL 213
Cdd:cd15056  106 PLVYK--MTPLRVAVMLGGCWVIPTFIsflpiMQGWNHIGIEDLIAFNCASGSTSCVFmvnkpfaiicsTVAFYIPALLM 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 214 AFTNHQIFRSIK--------------LSDSLSAAQKNKVKRSAIAVVTI------FLVCFAPYHVVLLVkaasfsfyqgd 273
Cdd:cd15056  184 VLAYYRIYVAAReqahqirslqragsSNHEADQHRNSRMRTETKAAKTLgiimgcFCVCWAPFFVTNIV----------- 252
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568980130 274 mDAVCAFESRlYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15056  253 -DPFIGYRVP-YLLWTAFLWLGYINSGLNPFLY 283
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
92-308 2.05e-03

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 39.39  E-value: 2.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  92 VPLWIIYIQNQhKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQ-RTAVTISACVILLVGLV 170
Cdd:cd15296   54 IPLYIPYVLTG-RWKFGRGLCKLWLVVDYLLCTASVFNIVLISYDRFLSVTRAVSYRAQKGMtRQAVLKMVLVWVLAFLL 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 171 NYPVFdmkveksFCFEPLRMNSKIA-GYHYLRF-----------TFGFAIPLGILAFTNHQIFRSIKlSDSLSAAQKNKV 238
Cdd:cd15296  133 YGPAI-------ISWEYIAGGSIIPeGECYAEFfynwyflmtasTLEFFTPFISVTYFNLSIYLNIQ-KRRFRLSRDKKV 204
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 239 KRSAIAVVTIFLVCFAPYHVVLLVKAAsfsfyqgdmdavCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15296  205 AKSLAIIVCVFGLCWAPYTLLMIIRAA------------CHGHCVPDYWYETSFWLLWVNSAINPVLYPL 262
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
51-308 2.15e-03

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 39.43  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  51 LLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLL 130
Cdd:cd15080   12 LLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALWSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 131 CCISCDRYMAVVYALESR--GHRHQRTAVTIS-----ACVIL-LVGLVNYPVFDMKVEKSFCFEPLRMNSKIAGYHYLRF 202
Cdd:cd15080   92 VVLAIERYVVVCKPMSNFrfGENHAIMGVAFTwvmalACAAPpLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMF 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 203 TFGFAIPLGILAFTNHQIFRSIK-------LSDSLSAAQKnKVKRSAIAVVTIFLVCFAPYhvvllvkaASFSFY----Q 271
Cdd:cd15080  172 VVHFTIPLIVIFFCYGRLVCTVKeaaaqqqESATTQKAEK-EVTRMVIIMVIAFLICWVPY--------ASVAFYifthQ 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568980130 272 GdmdavCAFESRLYTVSMVFlclSTVNSVADPIIYVL 308
Cdd:cd15080  243 G-----SDFGPIFMTIPAFF---AKSSAVYNPVIYIL 271
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
81-306 3.18e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 39.11  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  81 LSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTIS 160
Cdd:cd15326   42 LAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILAL 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 161 ACVILLVGLVNY-PVFDMKveksfcfEPLRMNSKIAG-----YHYLRFTFG-FAIPLG-ILAFTNHQIFRSIKLSDSLSA 232
Cdd:cd15326  122 LGVWVLSTVISIgPLLGWK-------EPAPPDDKVCEiteepFYALFSSLGsFYIPLIvILVMYCRVYIVALKFSREKKA 194
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568980130 233 AQKNKVkrsaiaVVTIFLVCFAPYHVVLLVKAASFSFYQGDmdavcafesrlyTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15326  195 AKTLGI------VVGMFILCWLPFFIALPLGSLFSHLKPPE------------TLFKIIFWLGYFNSCLNPIIY 250
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
105-306 3.89e-03

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 38.68  E-value: 3.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 105 WNLGPQACKVTA--YIFFCNIYISILLLccISCDRYMAVVYALESRGHRHQRTAVTIS---ACVILLVGLVNYPVFDMKV 179
Cdd:cd15403   66 WHFGAHFCRISAmlYWFFVLEGVAILLI--ISVDRFLIIVQRQDKLNPHRAKVMIAISwvlSFCISFPSVVGWTLVEVPA 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 180 EKSFCFEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKL--------SDSLSAAQKNKV------------- 238
Cdd:cd15403  144 RAPQCVLGYTESPADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRnavrihnhADSLCLSQVSKLglmglqrphqmnv 223
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568980130 239 ----KRSAIAVVTI----FLVCFAPYHVVLLVKAASFSFYQGdmdavcafeSRLYTVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15403  224 dmsfKTRAFTTILIlfvgFSLCWLPHTVFSLLSVFSRRFYYS---------SSFYPISTCVLWLSYLKSVFNPVIY 290
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
46-308 4.46e-03

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 38.66  E-value: 4.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIyiQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15171    7 CSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAH--AAWHGGSLGNPTCKVLVALSSVGLHS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVG-LVNYPVF-------DMKVEKSFCFEPLRMNSKIAGY 197
Cdd:cd15171   85 EALFNVLLTVQASRVFFHGRLASSARRVAPCGIIASVLAWLTAfLVTLPEFvfykpqmDSQKSKCAFSRPHFLPAEETFW 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 198 HY---LRFTF-GFAIPLGILAFTNHQIFRSIKlsdslSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGD 273
Cdd:cd15171  165 KYfltLKMNIvVLVFPLLVFIICCVQLRKTQR-----FRERQRDLSKLVFAIMVVFLLMWAPYNIALFLSAFKEHFSLRD 239
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568980130 274 mdavCAFESRLYTVSMVFLCLSTVNSVADPIIYVL 308
Cdd:cd15171  240 ----CKSSYHLDASVQVTKLIATTHCCVNPLLYAL 270
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
104-306 4.57e-03

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 38.57  E-value: 4.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 104 KWNLGPQACK--VTAYIFFCNIyiSILLLCCISCDRYMAVVYALESRGHRH-QRTAVTISA--------CVILLVGLVNY 172
Cdd:cd15060   65 KWLFGIHLCQmwLTCDILCCTA--SILNLCAIALDRYWAIHDPINYAQKRTlKRVLLMIVVvwalsaliSVPPLIGWNDW 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 173 P-VFDMKveksfcfEPLRMNSKiAGYHYLRFTFGFAIPLGILAFTNHQIFRSIklsdslsaAQKNKVKRSAIAVVTIFLV 251
Cdd:cd15060  143 PeNFTET-------TPCTLTEE-KGYVIYSSSGSFFIPLLIMTIVYVKIFIAT--------SKERRAARTLGIIMGVFVV 206
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568980130 252 CFAPYHVVLLVkaasFSFYQgdmdaVCAFESRlytVSMVFLCLSTVNSVADPIIY 306
Cdd:cd15060  207 CWLPFFLMYVI----LPFCE-----TCSPSAK---VVNFITWLGYVNSALNPVIY 249
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
46-180 5.04e-03

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 38.62  E-value: 5.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTawLTLLQVLQRN-VLA-------VYLFCLSLCELLYISTVPLWIIyIQNQHKWNLGPQACKVTAY 117
Cdd:cd15135    7 YSLILVAGILGNSAT--IKVTQVLQKKgYLQksvtdhmVSLACSDLLVLLLGMPVELYSA-IWDPFATPSGNIACKIYNF 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568980130 118 IFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISAcVILLVGLVNYPV-FDMKVE 180
Cdd:cd15135   84 LFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLICF-VWLTSALVALPLlFAMGTE 146
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
49-317 6.34e-03

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 37.96  E-value: 6.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  49 VCLLGLPANcLTAWLTLLQVLQR-NV-------LAVYLFCLSLcELLYISTVPLWII--YIQNQHKWNLGPqACKVTAYI 118
Cdd:cd15136   10 VFLLALVGN-IIVLLVLLTSRTKlTVprflmcnLAFADFCMGI-YLGLLAIVDAKTLgeYYNYAIDWQTGA-GCKTAGFL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 119 FFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISAC---------VILLVGLVNYpvfdMKVekSFCFePLR 189
Cdd:cd15136   87 AVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGgwifalimaLLPLVGVSSY----SKT--SICL-PFE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 190 mNSKIAGYHYLRFTFGF-AIPLGILAFTNHQIFRSIKLSDSLSAAQKNKV-KRSAIAVVTIFLvCFAPyhvvllvkAASF 267
Cdd:cd15136  160 -TETPVSKAYVIFLLLFnGLAFLIICGCYIKIYLSVRGSGRAANSNDTRIaKRMALLVFTDFL-CWAP--------IAFF 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568980130 268 SFyqgdmdaVCAFESRLYTVS-----MVFLclSTVNSVADPIIYVLGTDHSRQEV 317
Cdd:cd15136  230 GL-------TAAFGLPLISVSnakilLVFF--YPLNSCANPFLYAIFTKQFRRDC 275
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
92-306 7.23e-03

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 37.62  E-value: 7.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  92 VPLWIIYIQNQHKWNLGPQackvtayifFCNIYISILLLCC---------ISCDRYMAVVYALESRGHRHQRTAVTISAC 162
Cdd:cd15328   54 MPLSLVHELSGRRWQLGRS---------LCQVWISFDVLCCtasiwnvtaIALDRYWSITRHLEYTLRTRRRISNVMIAL 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 163 VILLVGLVNYPVFDMKVEKSFCFEPLRMNSKIAGYHYLRFTFG-FAIPLGILAFTNHQIFRsiklsdslsAAQKNKvkRS 241
Cdd:cd15328  125 TWALSAVISLAPLLFGWGETYSEDSEECQVSQEPSYTVFSTFGaFYLPLCVVLFVYWKIYK---------AAQKEK--RA 193
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568980130 242 AIAV---VTIFLVCFAPYHVVLLVkaasfsfyqgdmDAVCAFESRLYTVSmVFLCLSTVNSVADPIIY 306
Cdd:cd15328  194 ALMVgilIGVFVLCWIPFFLTELI------------SPLCSCDIPPIWKS-IFLWLGYSNSFFNPLIY 248
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
47-277 7.81e-03

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 37.83  E-value: 7.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  47 SAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLY-ISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYI 125
Cdd:cd15212    8 LAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTaLLCLPFAFLTLFSRPGWLFGDRLCLANGFFNACFGIV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 126 SILLLCCISCDRYMAVVYalESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKS-------------FCFEPLRMNs 192
Cdd:cd15212   88 STLTMTLISFDRYYAIVR--QPQGKIGRRRALQLLAAAWLTALGFSLPWYLLASAPEyyeklgfyhclyvLHSGPSRLG- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 193 kiAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDS--------LSAAQKNKVKRSAIAV---VTIFLVCFAPYHVVLL 261
Cdd:cd15212  165 --AAYSSVLIVLCYLLPFALMCFCHYNICKTVRLSESrvrpvttyAHLLRFYSEMRTATTVlimIVFIICCWGPYCLLGL 242
                        250
                 ....*....|....*.
gi 568980130 262 VKAASFSFYQGDMDAV 277
Cdd:cd15212  243 VAAAGGYQFPPLMDTV 258
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
46-315 8.77e-03

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 37.90  E-value: 8.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130  46 YSAVCLLGLPANCLTAWLTL----LQVLQRNVlAVYLFCLSLCELLYIS-TVPLWII-YIQNQHKWNLGPQACKVTAYIF 119
Cdd:cd15355    7 YLALFVVGTVGNSITLYTLArkksLQHLQSTV-HYHLASLALSDLLILLlAMPVELYnFIWVHHPWAFGDAACRGYYFLR 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 120 FCNIYISILLLCCISCDRYMAVVYALE-----SRGhRHQRTAVTISACVILLV------------------GLVNYPVFD 176
Cdd:cd15355   86 DACTYATALNVASLSVERYLAICHPFKakslmSRS-RTKKFISAIWLASALLAipmlftmgeqnrsgthpgGLICTPIVD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980130 177 MKVEK---------SFCFEPLR---MNSKIAgYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVkRSAIA 244
Cdd:cd15355  165 TSTLKvviqvnaflSFLFPMLVisvLNTLIA-NQLTVMVNQAEQENQVCTIGGQRTVLSVSMEPGRVQSLRHGV-LVLRA 242
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568980130 245 VVTIFLVCFAPYHVVLLVkaasFSFYQGDMDAVCAFESRLYtVSMVFLCLSTVNSVADPIIYVLGTDHSRQ 315
Cdd:cd15355  243 VVIAFVVCWLPYHVRRLM----FCYVSDEQWTTFLYDFYHY-FYMLTNVLFYVSSAINPILYNLVSANFRQ 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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