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Conserved domains on  [gi|568944218|ref|XP_006507026|]
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solute carrier organic anion transporter family member 1B2 isoform X1 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
26-557 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17457:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 455  Bit Score: 639.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  26 RIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIG 105
Cdd:cd17457    2 KMFLAALSFSYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGLG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 106 SILTALPHFFMGYYRYatendisslhnstltclvnqttsltgtspeimekGCEKGSNSYTWIYVLMGNMLRGIGETPIVP 185
Cdd:cd17457   82 SVLTALPHFFMGYYKY----------------------------------GCLKESGSYMWVYVLMGNMLRGIGETPIVP 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 186 LGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGLLCI 265
Cdd:cd17457  128 LGISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGFLVSGLFSI 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 266 ICSIPFFFLPkipkrsqkerknsaslhvlktdedknpvtnpttqekqapanltGFLWSLRSILTNEQYVIFLILTLLQIS 345
Cdd:cd17457  208 ISAIPFFFLP-------------------------------------------GFFQSLKSILTNRLYVMFVCLTLLQVS 244
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 346 SFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLIC 425
Cdd:cd17457  245 SFIGFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYFFIGC 324
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 426 ENKAFAGLTLTYDGMNPVDSHIDVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKlmNIEFYDCSCVS 505
Cdd:cd17457  325 ENKSVAGITMTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGK--PIVFHNCSCLE 402
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568944218 506 GSGFQKGNHSARLGECPR-DKCKTKYYFYITFQVIISFFTALGSTSLMLILIR 557
Cdd:cd17457  403 VTGSQNRNYSAHLGECPRdDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
 
Name Accession Description Interval E-value
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
26-557 0e+00

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 639.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  26 RIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIG 105
Cdd:cd17457    2 KMFLAALSFSYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGLG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 106 SILTALPHFFMGYYRYatendisslhnstltclvnqttsltgtspeimekGCEKGSNSYTWIYVLMGNMLRGIGETPIVP 185
Cdd:cd17457   82 SVLTALPHFFMGYYKY----------------------------------GCLKESGSYMWVYVLMGNMLRGIGETPIVP 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 186 LGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGLLCI 265
Cdd:cd17457  128 LGISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGFLVSGLFSI 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 266 ICSIPFFFLPkipkrsqkerknsaslhvlktdedknpvtnpttqekqapanltGFLWSLRSILTNEQYVIFLILTLLQIS 345
Cdd:cd17457  208 ISAIPFFFLP-------------------------------------------GFFQSLKSILTNRLYVMFVCLTLLQVS 244
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 346 SFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLIC 425
Cdd:cd17457  245 SFIGFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYFFIGC 324
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 426 ENKAFAGLTLTYDGMNPVDSHIDVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKlmNIEFYDCSCVS 505
Cdd:cd17457  325 ENKSVAGITMTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGK--PIVFHNCSCLE 402
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568944218 506 GSGFQKGNHSARLGECPR-DKCKTKYYFYITFQVIISFFTALGSTSLMLILIR 557
Cdd:cd17457  403 VTGSQNRNYSAHLGECPRdDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
27-617 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 618.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218   27 IFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGS 106
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  107 ILTALPHFfmgyyryatendisslhnstltclvnqttsltgtspeimekgcekgsnsytwIYVLMGNMLRGIGETPIVPL 186
Cdd:pfam03137  81 LLFALPHF----------------------------------------------------LSFFLGQLLLGIGGTPIYTL 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  187 GVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVdlrSVRITPQDARWVGAWWLGFIVNGLLCII 266
Cdd:pfam03137 109 GISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKV---SITLTPKDPRWVGAWWLGFLIAGLLLLL 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  267 CSIPFFFLPKIPKRSQKERKNSASLHVLKTDEDKNPvtnpTTQEKQAPANLTGFLWSLRSILTNEQYVIFLILTLLQISS 346
Cdd:pfam03137 186 TAIPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKK----TKSLKKLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLL 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  347 FIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLICE 426
Cdd:pfam03137 262 IAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCP 341
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  427 NKAFAGLTLTYDGMNPVDshiDVPLSYCNSDCICDKNQWEPVCGENGvTYISPCLAGCKSFRGDKKLMNIEFYDCSCVSG 506
Cdd:pfam03137 342 NSPVAGITVPYGGTQQLS---GNLTSSCNSDCSCSTSAYSPVCGSDG-GYTSPCPCGAGCSSSSGAGKSTYICNCCCSCG 417
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  507 SGFQKGNHSARLGECPRDkCKTKYYFYITFQVIISFFTALGSTSLMLILIRSVQPELKSLGMGFHSLVVRTLGGILAPVY 586
Cdd:pfam03137 418 SQDSGGNGSATPGKCPSD-CSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPIL 496
                         570       580       590
                  ....*....|....*....|....*....|.
gi 568944218  587 YGALIDRTCMKWSvTSCGARGACRLYNSRLF 617
Cdd:pfam03137 497 FGALIDSTCLLWG-KTCGGRGNCWLYDNDKL 526
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
27-641 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 540.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218   27 IFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGS 106
Cdd:TIGR00805  33 MFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGS 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  107 ILTALPHFFMGYYRYATEN----DISSLHnsTLTCLVNQTTSLtgtSPEIMEKGCEKGSNSYTWIYVLMGNMLRGIGETP 182
Cdd:TIGR00805 113 LLSSLPHFLMGRYSYSTTVsstgNLSSAN--SFLCMENLTQTL---RPTQDPSECQKQHKSLMWLLFLVSNILRGIGATP 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  183 IVPLGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGL 262
Cdd:TIGR00805 188 IFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWIGFLVCGF 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  263 LCIICSIPFFFLPKIPKRSQKeRKNSASLHVLKTDEDKNPVtnpttqEKQAPANLTGFLWSLRSILTNEQYVIFLILTLL 342
Cdd:TIGR00805 268 VALLTSIPLFFFPKTLPKEGK-RVNVDVHEAEKLEKSRGED------RKKNSGITKDFPKFIKRLLCNKIYMLVILAQVI 340
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  343 QISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFL 422
Cdd:TIGR00805 341 DVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKFL 420
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  423 LICENKAFAGLTL-TYDGMNPVDSHIDvplsyCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKLMNieFYDC 501
Cdd:TIGR00805 421 ITCESAPVAGVNNpSNDQPLYVENRTD-----CNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGSNMV--FTNC 493
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  502 SCVSGSgfqkGNHSARLGECPRDKCKTKYYFYITFqVIISFFTALGSTSLMLILIRSVQPELKSLGMGFHSLVVRTLGGI 581
Cdd:TIGR00805 494 SCIQTP----GNSSAKKGLCDPPCATSLQYFLILF-IPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTI 568
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568944218  582 LAPVYYGALIDRTCMKWSVTSCGARGACRLYNSRLFGMIYVGLSIALKTP--ILLLYVALIY 641
Cdd:TIGR00805 569 PAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSslLPLFFILILA 630
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
26-423 1.78e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 75.40  E-value: 1.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  26 RIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIG 105
Cdd:COG2814    9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 106 SILTALphffmgyyryatendisslhnstltclvnqttsltgtspeimekgcekgSNSYTWIYVLMgnMLRGIGETPIVP 185
Cdd:COG2814   89 SLLCAL-------------------------------------------------APSLWLLLAAR--FLQGLGAGALFP 117
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 186 LGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYvdvgyvdlrsvritpqdarwvgAWWLGFIVNGLLCI 265
Cdd:COG2814  118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----------------------GWRWVFLVNAVLAL 175
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 266 ICSIPFFFLpkIPKRSQKERKNSASlhvlktdedknpvtnpttqekqapanltgflwSLRSILTNEQYVIFLILTLLQIS 345
Cdd:COG2814  176 LALLLLLRL--LPESRPAARARLRG--------------------------------SLRELLRRPRLLLLLLLAFLLGF 221
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 346 SFIGSFTYLFKFIEQQFGQTASQANFLLGVITIpTMASGMFLGGYLIKRLK--------LTLLGITKFVFFTTTMAYVFY 417
Cdd:COG2814  222 GFFALFTYLPLYLQEVLGLSASAAGLLLALFGL-GGVLGALLAGRLADRFGrrrllligLLLLALGLLLLALAGSLWLLL 300

                 ....*.
gi 568944218 418 LSYFLL 423
Cdd:COG2814  301 LALFLL 306
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
457-493 6.16e-04

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 38.04  E-value: 6.16e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568944218   457 DCICDKNqWEPVCGENGVTYISPCLAGCKSFRGDKKL 493
Cdd:smart00280   3 PEACPRE-YDPVCGSDGVTYSNECHLCKAACESGKSI 38
 
Name Accession Description Interval E-value
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
26-557 0e+00

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 639.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  26 RIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIG 105
Cdd:cd17457    2 KMFLAALSFSYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGLG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 106 SILTALPHFFMGYYRYatendisslhnstltclvnqttsltgtspeimekGCEKGSNSYTWIYVLMGNMLRGIGETPIVP 185
Cdd:cd17457   82 SVLTALPHFFMGYYKY----------------------------------GCLKESGSYMWVYVLMGNMLRGIGETPIVP 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 186 LGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGLLCI 265
Cdd:cd17457  128 LGISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGFLVSGLFSI 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 266 ICSIPFFFLPkipkrsqkerknsaslhvlktdedknpvtnpttqekqapanltGFLWSLRSILTNEQYVIFLILTLLQIS 345
Cdd:cd17457  208 ISAIPFFFLP-------------------------------------------GFFQSLKSILTNRLYVMFVCLTLLQVS 244
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 346 SFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLIC 425
Cdd:cd17457  245 SFIGFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYFFIGC 324
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 426 ENKAFAGLTLTYDGMNPVDSHIDVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKlmNIEFYDCSCVS 505
Cdd:cd17457  325 ENKSVAGITMTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGK--PIVFHNCSCLE 402
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568944218 506 GSGFQKGNHSARLGECPR-DKCKTKYYFYITFQVIISFFTALGSTSLMLILIR 557
Cdd:cd17457  403 VTGSQNRNYSAHLGECPRdDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
27-617 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 618.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218   27 IFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGS 106
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  107 ILTALPHFfmgyyryatendisslhnstltclvnqttsltgtspeimekgcekgsnsytwIYVLMGNMLRGIGETPIVPL 186
Cdd:pfam03137  81 LLFALPHF----------------------------------------------------LSFFLGQLLLGIGGTPIYTL 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  187 GVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVdlrSVRITPQDARWVGAWWLGFIVNGLLCII 266
Cdd:pfam03137 109 GISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKV---SITLTPKDPRWVGAWWLGFLIAGLLLLL 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  267 CSIPFFFLPKIPKRSQKERKNSASLHVLKTDEDKNPvtnpTTQEKQAPANLTGFLWSLRSILTNEQYVIFLILTLLQISS 346
Cdd:pfam03137 186 TAIPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKK----TKSLKKLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLL 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  347 FIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLICE 426
Cdd:pfam03137 262 IAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCP 341
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  427 NKAFAGLTLTYDGMNPVDshiDVPLSYCNSDCICDKNQWEPVCGENGvTYISPCLAGCKSFRGDKKLMNIEFYDCSCVSG 506
Cdd:pfam03137 342 NSPVAGITVPYGGTQQLS---GNLTSSCNSDCSCSTSAYSPVCGSDG-GYTSPCPCGAGCSSSSGAGKSTYICNCCCSCG 417
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  507 SGFQKGNHSARLGECPRDkCKTKYYFYITFQVIISFFTALGSTSLMLILIRSVQPELKSLGMGFHSLVVRTLGGILAPVY 586
Cdd:pfam03137 418 SQDSGGNGSATPGKCPSD-CSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPIL 496
                         570       580       590
                  ....*....|....*....|....*....|.
gi 568944218  587 YGALIDRTCMKWSvTSCGARGACRLYNSRLF 617
Cdd:pfam03137 497 FGALIDSTCLLWG-KTCGGRGNCWLYDNDKL 526
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
25-558 0e+00

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 579.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  25 FRIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGI 104
Cdd:cd17459    1 LKIFLAALSFAYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 105 GSILTALPHFFMGYYRYATEndISSLHNSTLT---CLV--NQTTSLTGTSPEIMEKGCEKGSNSYTWIYVLMGNMLRGIG 179
Cdd:cd17459   81 GTFLIALPHFFMGRYKYETA--IQSSSNSTVSispCSLepSPQLHSIESSDSKTGTGCEKEPGSSMWIYVFLGNLLRGIG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 180 ETPIVPLGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIV 259
Cdd:cd17459  159 ETPVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGYLI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 260 NGLLCIICSIPFFFLPK-IPKrsqkerknsaslhvlktdedknpvtnpttqekqapanltGFLWSLRSILTNEQYVIFLI 338
Cdd:cd17459  239 AGVITLLSAVPFWFLPKsLPK---------------------------------------DFLPSLKNLLGNPVYFLYLC 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 339 LTLLQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYL 418
Cdd:cd17459  280 TSILQFNSLIGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLLL 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 419 SYFLLICENKAFAGLTLTYDGMNPVDSHIDVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKlmNIEF 498
Cdd:cd17459  360 SFFAMGCENSDVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGK--NTVF 437
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568944218 499 YDCSCVSGSGFQKGNHSARLGECPR-DKCKTKYYFYITFQVIISFFTALGSTSLMLILIRS 558
Cdd:cd17459  438 HNCSCIGIPSSASGSSSAILGQCPKgNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
26-557 0e+00

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 563.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  26 RIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIG 105
Cdd:cd17400    2 KMFLLALSCAFVAKTLSGSYMKSMITQIERRFNIPSSLVGFIDGSFEIGNLLVIIFVSYFGTKLHRPKMIGIGCVIMGLG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 106 SILTALPHFFMGYYRYatendisslhnstltclvnqttsltgtspeimekgcekgsnSYTWIYVLMGNMLRGIGETPIVP 185
Cdd:cd17400   82 CFLKALPHFFMNQYEY-----------------------------------------SLMWIYVFVGNILRGIGETPILP 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 186 LGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGLLCI 265
Cdd:cd17400  121 LGISYIDDFAKEENSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDIGFVNLDDIIITPTDTRWVGAWWLGFLICGGVSV 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 266 ICSIPFFFLPKIpkrsqkerknsaslhvlktdedknpvtnpttqekqapanltgflwslrsiltneqYVIFLILTLLQIS 345
Cdd:cd17400  201 LTAIPFFFLPPI-------------------------------------------------------YMLFILVSVIQFN 225
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 346 SFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLIC 425
Cdd:cd17400  226 SFVGMITYMPKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLSFLMTC 305
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 426 ENKAFAGLTLTYDGMNPVDSHIDVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKlmNIEFYDCSCVS 505
Cdd:cd17400  306 ENSSVAGLTTSYEGIPPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSACLAGCETSIGTGK--NIVFYNCSCIQ 383
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568944218 506 GSGFQKGNHSARLGECPRDK-CKTKYYFYITFQVIISFFTALGSTSLMLILIR 557
Cdd:cd17400  384 TSGNSSANLSLCDGGCPRDPdCSLMFQYFLIISVMSSFIYSLGGIPGYMLLLR 436
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
27-641 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 540.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218   27 IFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGS 106
Cdd:TIGR00805  33 MFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGS 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  107 ILTALPHFFMGYYRYATEN----DISSLHnsTLTCLVNQTTSLtgtSPEIMEKGCEKGSNSYTWIYVLMGNMLRGIGETP 182
Cdd:TIGR00805 113 LLSSLPHFLMGRYSYSTTVsstgNLSSAN--SFLCMENLTQTL---RPTQDPSECQKQHKSLMWLLFLVSNILRGIGATP 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  183 IVPLGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGL 262
Cdd:TIGR00805 188 IFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWIGFLVCGF 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  263 LCIICSIPFFFLPKIPKRSQKeRKNSASLHVLKTDEDKNPVtnpttqEKQAPANLTGFLWSLRSILTNEQYVIFLILTLL 342
Cdd:TIGR00805 268 VALLTSIPLFFFPKTLPKEGK-RVNVDVHEAEKLEKSRGED------RKKNSGITKDFPKFIKRLLCNKIYMLVILAQVI 340
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  343 QISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFL 422
Cdd:TIGR00805 341 DVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKFL 420
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  423 LICENKAFAGLTL-TYDGMNPVDSHIDvplsyCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKLMNieFYDC 501
Cdd:TIGR00805 421 ITCESAPVAGVNNpSNDQPLYVENRTD-----CNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGSNMV--FTNC 493
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  502 SCVSGSgfqkGNHSARLGECPRDKCKTKYYFYITFqVIISFFTALGSTSLMLILIRSVQPELKSLGMGFHSLVVRTLGGI 581
Cdd:TIGR00805 494 SCIQTP----GNSSAKKGLCDPPCATSLQYFLILF-IPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTI 568
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568944218  582 LAPVYYGALIDRTCMKWSVTSCGARGACRLYNSRLFGMIYVGLSIALKTP--ILLLYVALIY 641
Cdd:TIGR00805 569 PAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSslLPLFFILILA 630
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
26-558 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 532.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  26 RIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIG 105
Cdd:cd17458    3 KIFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSLG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 106 SILTALPHFFMGYYRYatENDISSLHNSTLT---CLVNQTTSLtgtSPEIMEKGCEKGSNSYTWIYVLMGNMLRGIGETP 182
Cdd:cd17458   83 CFLASLPHFLMGRYEY--ESTVSTTSNSSSRvplCLANQSLSH---NVTQLPSECEKESMSLMWIFVLVGNLLRGIGETP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 183 IVPLGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGL 262
Cdd:cd17458  158 VMPLGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAG 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 263 LCIICSIPFFFLPKIPKRSQKERKNSASLHVLKTDEDKNpvTNPTTQEKQAPAnlTGFLWSLRSILTNEQYVIFLILTLL 342
Cdd:cd17458  238 VNFLAGLPFWFLPKSLPKEGEENETEPSKTLTVELEENK--GQETKQEMYEIA--KDFLPFLKSLFRNPIYMLFIIVTVL 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 343 QISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFL 422
Cdd:cd17458  314 QFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFW 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 423 LICENKAFAGLTLTYDGMNPVDSHIDVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKlmNIEFYDCS 502
Cdd:cd17458  394 MGCDNSPVAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGK--NMVFQNCS 471
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568944218 503 CVSGSGFQKGNHSArLGECPRDK-CKTKYYFYITFQVIISFFTALGSTSLMLILIRS 558
Cdd:cd17458  472 CVAASGFPSQNSSA-VGQCDKGEtCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
26-557 1.72e-124

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 376.19  E-value: 1.72e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  26 RIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIG 105
Cdd:cd17336    2 KVFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 106 SILTALPHFFmgyyryatendisslhnstltclvnqttsltgtspeimekgcekgsnsytwiyvLMGNMLRGIGETPIVP 185
Cdd:cd17336   82 CFLLALPHFL------------------------------------------------------FVGQFLLGIGSSPLYT 107
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 186 LGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDlrsVRITPQDARWVGAWWLGFIVNGLLCI 265
Cdd:cd17336  108 LGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVP---LGITPDDPRWIGAWWLGFLILGILLL 184
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 266 ICSIPFFFLPKIpkrsqkerknsaslhvlktdedknpvtnpttqekqapanltgflwslrsiltneqYVIFLILTLLQIS 345
Cdd:cd17336  185 IVSIPLFFFPPI-------------------------------------------------------FILLLLAIVFESF 209
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 346 SFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLIC 425
Cdd:cd17336  210 AISGFSTFLPKYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLFFLGC 289
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 426 ENKAFAGLTLTYDGMNpvdshiDVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKLMNieFYDCSCVS 505
Cdd:cd17336  290 DNPPIAGVTTPYGSSS------SPITSSCNSDCNCSDSSFSPVCGSDGITYFSPCHAGCTSSDAGNGTKT--YSNCSCIN 361
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568944218 506 GSGFQKGNHSARLGECPrdKCKTKYYFYITFQVIISFFTALGSTSLMLILIR 557
Cdd:cd17336  362 SGTATSSGCPPDCSVAP--NCCSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
26-522 4.13e-103

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 322.91  E-value: 4.13e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  26 RIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIG 105
Cdd:cd17461    3 KVFVLCHGLLQLSQLLYSAYFKSSLTTIEKRFGLSSLSSGLISSLHEIGNAVLIIFVSYFGSRVHRPRLIGIGGLLLALG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 106 SILTALPHFFMGYYRYATendisslhnstltclvnqttsltgtspeimekgcekgsnsytWIYVLMGNMLRGIGETPIVP 185
Cdd:cd17461   83 AFLLTLPHFLSEPYQYSM------------------------------------------WVLMVVAQLLAGIGTVPIQP 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 186 LGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGLLCI 265
Cdd:cd17461  121 FGISYVDDFAEPSNSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDIGRVNTATVELTPADPRWIGAWWLGLLISSGLLV 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 266 ICSIPFFFLPKipkrsqkerknsaSLHVLKTDEDKNPVTNPTTQEKQAPANLTGFLWSLRSI----LTNEqyvIFLILTL 341
Cdd:cd17461  201 LTSLPYFFFPR-------------EMLVGKKPSPEGDMLRKKEDEKKEEGSLLDFIKRFPKMfvklLLNP---LFMLLVL 264
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 342 LQ--ISSFIGSF-TYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYL 418
Cdd:cd17461  265 AQctFSSVIAGLsTFLNKFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISIMLCV 344
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 419 SYFLLICENKAFAGltltydGMNPVDSHIDVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKLMNIEF 498
Cdd:cd17461  345 PLFFMGCSTQDVAG------VYPKTSNSSDGPHLSCSANCSCPESAFNPVCGENGIEYISPCHAGCTNSNMDSSTYRQQI 418
                        490       500
                 ....*....|....*....|....*
gi 568944218 499 Y-DCSCVSGSGfqkGNHSARLGECP 522
Cdd:cd17461  419 YsNCSCIPDLS---GEKPAKTGSCP 440
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
48-557 1.26e-100

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 314.58  E-value: 1.26e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  48 SSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGSILTALPHFFMgyyryatendi 127
Cdd:cd17403   25 VSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMGIGSLVFALPHFTV----------- 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 128 sslhnstltclvnqttsltgtspeimekgcekgsnsytwiyVLMGNMLRGIGETPIVPLGVSYIDDFAKEGNSSMYLGTL 207
Cdd:cd17403   94 -----------------------------------------FILAQLLHGAGATPLYTLGVTYLDENVSTKMSPLYIGIF 132
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 208 HTIAMIGPILGFIMSSVFAKLYVDVGYVDlRSVRITPQDARWVGAWWLGFIVNGLLCIICSIPFFFLPkipkrsqkerkn 287
Cdd:cd17403  133 YAMAILGPAIGYVLGGFLLNLYTDIDQVD-SELGLTPDDPRWVGAWWLGFLISGALALIIAFPLLGFP------------ 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 288 saslhvlktdedknpvtnPTtqekqapanltgflwslrsiltneqyviFLILTLLQIS-SFIGS--FTYLFKFIEQQFGQ 364
Cdd:cd17403  200 ------------------PT----------------------------FMFLNLAGASeGMLLAgfATFLPKLIESQFSL 233
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 365 TASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSyFLLICENKAFAGLTLTYDGMNPVD 444
Cdd:cd17403  234 SASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLFSFI-LLIYCPNAPFAGVTVPYGNSPLEG 312
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 445 SHIDVplSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKLMNieFYDCSCVSGSGFQKGNHSARLGECPRD 524
Cdd:cd17403  313 TSNLT--STCNADCHCSEDFYDPVCGSDGVTYYSPCHAGCTTSHGDDGQKV--YSNCSCIQSNSSKTSTAATGKACPCET 388
                        490       500       510
                 ....*....|....*....|....*....|...
gi 568944218 525 KCKTKYYFYITFQVIIsFFTALGSTSLMLILIR 557
Cdd:cd17403  389 CCQKLYLFLAVFFLLI-VFTFMSSTPALSATLR 420
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
26-557 1.45e-96

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 304.28  E-value: 1.45e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  26 RIFLAALSF-SYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGI 104
Cdd:cd17404    1 KAFLVCMCLlIFIQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 105 GSILTALPHFFMgyyryatendisslhnstltclvnqttsltgtspeimekgcekgsnsytwiyvlMGNMLRGIGETPIV 184
Cdd:cd17404   81 GSFLFSLPHFFI------------------------------------------------------LAQILIGMGGTPIF 106
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 185 PLGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVdlrSVRITPQDARWVGAWWLGFIVNGLLC 264
Cdd:cd17404  107 TLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDPLST---PPDISPGDPRWIGAWWGGFLLCGIAL 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 265 IICSIPFFFLPKipkrsqkerknsaslhvlktdedknpvtnpttqekqapanltgflwslrsiltneqyVIFLILTL--- 341
Cdd:cd17404  184 LLVAFPFFTFPK---------------------------------------------------------MTFLVVSLgyc 206
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 342 LQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYF 421
Cdd:cd17404  207 MELAIVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTLF 286
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 422 LLICENKAFAGLTLTY-DGMNPVDSHIDVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFrGDKKLMNIEFYD 500
Cdd:cd17404  287 FLGCESIKLAGITIPYtTGPSLSSTHGRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCTSV-GNTSTGIRNYTN 365
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568944218 501 CSCV---SGSGFQKGNHS--ARLGECPRDkCKTKYYFYItFQVIISFFTALGSTSLMLILIR 557
Cdd:cd17404  366 CACLqsrSSISPPTVGQGsqLQAGPCSRT-CNTLIPFLI-LLFIVTLITACAQMPALMITLR 425
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
46-555 6.46e-96

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 304.38  E-value: 6.46e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  46 MKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGSILTALPHFFMGYYRYATen 125
Cdd:cd17460   22 LKSSISTIEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSLAGFLMALPHFISEPYEYGI-- 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 126 disslhnstltclvnqttsltgtspeimekgcekgsnsytwiyVLMGNMLRGIGETPIVPLGVSYIDDFAKEGNSSMYLG 205
Cdd:cd17460  100 -------------------------------------------LFLGQLLLGIGGVPIQPFGISYIDDFASESNSPLYLG 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 206 TLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGLLCIICSIPFFFLP-KIPKRSQKE 284
Cdd:cd17460  137 ILFAVTVLGPGFGFMLGSAMLRFYVDIDKMSEDEISLEIGDPRWVGAWWLGFLIAATLVALSAVPYFFFPrEMPKEVVEL 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 285 RKNSASLHVLKTDEDKnpvtnPTTQEKQApANLTGFLWSL-RSILTNEQYVIFLILTLLQI--SSFI-GSFTYLFKFIEQ 360
Cdd:cd17460  217 QPREKKLAKTMLKKLK-----SLSDILQN-LSLLQFIKKFpRILLRTLRNPIYLLVVLAQVnlSAMVaGLATFMGKFLER 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 361 QFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLICENKAFAGLTLTYDgm 440
Cdd:cd17460  291 QFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGCGAMCVLGMLLCLFFALPLLFIGCSTQKIAGITHRTS-- 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 441 npvDSHIDVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFR---GDKKLMNieFYDCSCVSGSGFQKgnhSAR 517
Cdd:cd17460  369 ---SSPGLELSSQCSEACSCPPEAFNPVCGSDGVEYISPCHAGCKSVNvqaLDNSVVN--YTDCSCVSEGGPVG---AAS 440
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 568944218 518 LGECPrdkcKTKYYFYITFQVIISFFTALGS----TSLMLIL 555
Cdd:cd17460  441 PGTCG----SGCSHLLVPFMLLVSLGGFLASlshtPSFMLIL 478
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
26-557 2.34e-90

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 288.75  E-value: 2.34e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  26 RIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIG 105
Cdd:cd17402    2 KIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 106 SILTALPHFFMGYYRyatendisslhnstltclvnqttsltgtspeimekgcekgsNSYTWIYVLMGNMLRGIGETPIVP 185
Cdd:cd17402   82 ALLSALPEFLTHQYK-----------------------------------------TNMMYLLLIGAQVLLGIGATPVQP 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 186 LGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGLLCI 265
Cdd:cd17402  121 LGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSKLDITPDDPRWIGAWWGGFLLCGALLF 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 266 ICSIPFFFLPKipkrsqkerknsaslhvlktdedknpvtnpTTQEKQAPANLTgflwslRSILTNEQYVIFLILTLLQIS 345
Cdd:cd17402  201 FSALLMFGFPQ------------------------------SLQQLRVIPKVT------KHLLSNPVFTCIVLAACMEIA 244
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 346 SFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLIC 425
Cdd:cd17402  245 VVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGC 324
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 426 ENKAFAGLTLTYDGMNPVDSHIDvPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSfrgdkklMNIEfyDCSCVs 505
Cdd:cd17402  325 DTGPVAGVTVPYGNDTAPGSSLD-PYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSS-------TNLS--GCACL- 393
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568944218 506 gSGFQKGNHSARLGECPRDKCKTKYYFYITFQVIISFFTALGSTSLMLILIR 557
Cdd:cd17402  394 -SSVPAENATVVPGKCPSPGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
26-555 4.68e-90

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 287.90  E-value: 4.68e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  26 RIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIG 105
Cdd:cd17401    2 KVFVLCHGLLQLCQLLYSGYLKSSITTIEKRFGLSSSSSGLLASFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLAAG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 106 SILTALPHFFMGYYRYAtendisslhnstltclvnqttsltgtspeIMekgcekgsnsytwiyvLMGNMLRGIGETPIVP 185
Cdd:cd17401   82 AFLLTLPHFISEPYQYG-----------------------------IM----------------VVAQLLLGIGGVPIQP 116
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 186 LGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGLLCI 265
Cdd:cd17401  117 FGISYIDDFAEPSNSPLYLGILFAVTVFGPAFGYLLGSVMLRLYVDIGRMNTAAVNLVPGDPRWIGAWWLGFLIAAALLV 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 266 ICSIPFFFLPKIPKRSqkerknsaslhvlktdedknpvtnPTTqekqapanltgFLWSLRSiltneqyVIFLILTLLQI- 344
Cdd:cd17401  197 LTSFPYFFFPRFIKRF------------------------PCI-----------FLRTLRN-------PIFLLVVLAQVt 234
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 345 -SSFI-GSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFL 422
Cdd:cd17401  235 lSSMIaGLATFLNKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIFCVPLFF 314
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 423 LICENKAFAGLTltydgmNPVDSHIDVPLSY-CNSDCICDKNQWEPVCGENGVTYISPCLAGCKSF--RGDKKLMNIEFY 499
Cdd:cd17401  315 IGCSTPTIAGVY------PPSSSSSIHPQSPaCRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSNInmSTSATSKQVIYT 388
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 500 DCSCVSGsgfqkGNHSARLGECPrdkcKTKYYFYITFQVIISFFTALGS----TSLMLIL 555
Cdd:cd17401  389 NCSCVTG-----GSASAKTGSCP----SPCSHLLLPFIFLISLVSLIAClshtPSFMMIL 439
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
24-548 2.10e-74

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 246.28  E-value: 2.10e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  24 GFRIFLAALSFsyickaLGGVI----MKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGC 99
Cdd:cd17462    3 GVLFFLCAASF------LQGMTvngfINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 100 FIMGIGSILTALPHF--FMgyyryatendisslhnstltclvnqttsltgtspeimekgcekgsnsytwiyvlMGNMLRG 177
Cdd:cd17462   77 LIMGLGSLVFALPHFtvFM------------------------------------------------------LGQFLHG 102
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 178 IGETPIVPLGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGyvdlRSVRITPQDARWVGAWWLGF 257
Cdd:cd17462  103 IGATPLYTLGVTYLDENVKSNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIG----RQTELTPENPLWVGAWWIGF 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 258 IVNGLLCIICSIPFFFLPK-IPKrsqkerknsaslhVLKtdedknpvtNPTtqekqapanltgflwslrsiltneqyVIF 336
Cdd:cd17462  179 LGAGAAALLIALPILGYPRqLPG-------------LLK---------NPT--------------------------FIF 210
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 337 LILTLLQISSFI-GSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAyV 415
Cdd:cd17462  211 LCLAGATEATLIaGMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKFCLICTVVS-L 289
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 416 FYLSYFLLICENKAFAGLTLTYDGMNPVDSHIDVPLSyCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKLMN 495
Cdd:cd17462  290 LAIFIFSLHCPNVPMAGVTASYRGSVLPEGSLNLTAL-CNADCRCLEEIYSPVCGADGLMYYSPCHAGCSEAYSDIRNGQ 368
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568944218 496 IEFYDCSCVSGSGFQKGNHSarlGECPRDKCKTKYYFYITFQVIISFFTALGS 548
Cdd:cd17462  369 KVYQDCSCVAGNLSVGFGEA---SAGKCTSNCNHMPLLLAFVFLVILFTFLCS 418
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
49-553 6.94e-67

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 226.16  E-value: 6.94e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  49 SITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGSILTALPHFFMgyyryatendis 128
Cdd:cd17463   26 SISTIEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIGLGSLVFSLPHFFV------------ 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 129 slhnstltclvnqttsltgtspeimekgcekgsnsytwiyVLMGNMLRGIGETPIVPLGVSYIDDFAKEGNSSMYLGTLH 208
Cdd:cd17463   94 ----------------------------------------FILGQLLLGVGGTPLYTLGTAYIDDSVPTHKSSLYIGIGY 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 209 TIAMIGPILGFIMSSVFAKLYVDVGYVDlrSVRITPQDARWVGAWWLGFIVNGLLCIICSIPFFFLPKipkrsqkerkns 288
Cdd:cd17463  134 GMSVLGPAIGYLLGGQLLNIYIDVNKGQ--SVDLTEEDPRWLGAWWIGFLMCWLIAWCLIAPFSCFPK------------ 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 289 aslhvlktdedknpvtnpttqekqapanltgflwSLRSILTNEQYVIFLILTLLQISSFIGSFTYLFKFIEQQFGQTASQ 368
Cdd:cd17463  200 ----------------------------------HLPGLLKNPVFMCLTISSCSEALITTGFATFLPKFIENQFGQTSSF 245
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 369 ANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLICENKAFAGLTLTYDGMNPVdSHID 448
Cdd:cd17463  246 AAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLSVFIFAKCGNDPFAGVSETYNGTGKI-GNLT 324
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 449 VPlsyCNSDCICDKNQWEPVCGENGVTYISPCLAGCKS--FRGDKKLmnieFYDCSCVsgsGFQKGNHSARLGECP-RDK 525
Cdd:cd17463  325 AP---CNANCSCLSSFYYPVCGADGVQYFSPCFAGCTNenLHDKKKV----YYNCSCI---GNFTEEFSANTTKCEeGKK 394
                        490       500       510
                 ....*....|....*....|....*....|....
gi 568944218 526 CKTK------YYFYITFQVIISFFTALGSTSLML 553
Cdd:cd17463  395 CETTcknlpiFLCFFFFVVIFTFMTSTPITVAIL 428
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
23-557 7.15e-35

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 137.67  E-value: 7.15e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  23 DGFRIFLAALSfsyICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIM 102
Cdd:cd17405    2 DGFMILYCILV---LIQGAVFGLVDMSIGIFQVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLM 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 103 GIGSILTALPHFfmgyyryatendisslhnstltclvnqttsltgtspeimekgcekgsnsytwIYVLMGNMLRGIGETP 182
Cdd:cd17405   79 GLGSMLFAFPFF----------------------------------------------------TFHIAGQCIQGIAGMP 106
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 183 IVPLGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVgyvdlRSVRITPQDA--RWVGAWWLGFIVN 260
Cdd:cd17405  107 IYILGITFIFDNIPTSSAGIYLGIAHSAYLIGYLLGYVGGLPNFQPPPNE-----KSVEIEVNKVyqLWQSGWWKTFLIA 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 261 GLLCIICSIPFFFLPKipkrsqkerknsaslhvlktdedknpvtnpttqekqapanltgflwSLRSILTNEQYVIFLILT 340
Cdd:cd17405  182 AAIAWCTSFPLVCFPT----------------------------------------------SLPGLLKNPLLLCQAICK 215
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 341 LLQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSY 420
Cdd:cd17405  216 ATEYLTFIGALEFLPHYLENQFLLTPGIASLLTGAFLIPGGAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFVLI 295
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 421 FLLICENKAFAGLTLTYDGMNPVdSHIDVPlsyCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSfrgdKKLMNIE--F 498
Cdd:cd17405  296 FFVECQTVTFAGINEDYDGYGQL-GNLTAP---CNEYCDCTSSLYTSICGRDEIEYFSPCFAGCKA----SKVSNTEktY 367
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568944218 499 YDCSCV----SGSGFQKGNHSARLGECPRDKCKTKYYFYITFQVIIsfFTALGSTSLMLILIR 557
Cdd:cd17405  368 YNCSCIkeglAAADDEGDFIDAIAGKCDSKCYKLPLFFAFYFSATV--FSNMCSIPIILIILR 428
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
450-505 2.03e-23

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 93.52  E-value: 2.03e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568944218 450 PLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKLMNieFYDCSCVS 505
Cdd:cd01330    1 LTSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNSTGSGGSKI--YTNCSCVG 54
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
32-424 1.10e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 85.56  E-value: 1.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  32 LSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGSILTAL 111
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 112 PHffmgyyryatendisslhnstltclvnqttsltgtspeimekgcekgsnSYTWIYVLMgnMLRGIGETPIVPLGVSYI 191
Cdd:cd06174   81 AP-------------------------------------------------SFWLLLLGR--FLLGLGSGLIDPAVLALI 109
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 192 DDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAklyvdvgyvdlrsvritpqdARWVGAWWLGFIVNGLLCIICSIPF 271
Cdd:cd06174  110 ADLFPERERGRALGLLQAFGSVGGILGPLLGGILA--------------------SSLGFGWRAVFLIAAALALLAAILL 169
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 272 FFLPKIPKRSQKERKnsaslhvlktdedknpvtnpttqekqAPANLTGFLWSLRSILTNEQYVIFLILTLLQISSFIGSF 351
Cdd:cd06174  170 LLVVPDPPESARAKN--------------------------EEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFS 223
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568944218 352 TYLFKFIEQQFGQTASQANFLLGVITIPTMAsGMFLGGYLIKR-LKLTLLGITKFVFFTTTMAYVFYLSYFLLI 424
Cdd:cd06174  224 TLLPLFLLDLGGLSVAVAGLLLSLFGLAGAL-GSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLL 296
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
26-423 1.78e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 75.40  E-value: 1.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  26 RIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIG 105
Cdd:COG2814    9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 106 SILTALphffmgyyryatendisslhnstltclvnqttsltgtspeimekgcekgSNSYTWIYVLMgnMLRGIGETPIVP 185
Cdd:COG2814   89 SLLCAL-------------------------------------------------APSLWLLLAAR--FLQGLGAGALFP 117
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 186 LGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYvdvgyvdlrsvritpqdarwvgAWWLGFIVNGLLCI 265
Cdd:COG2814  118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----------------------GWRWVFLVNAVLAL 175
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 266 ICSIPFFFLpkIPKRSQKERKNSASlhvlktdedknpvtnpttqekqapanltgflwSLRSILTNEQYVIFLILTLLQIS 345
Cdd:COG2814  176 LALLLLLRL--LPESRPAARARLRG--------------------------------SLRELLRRPRLLLLLLLAFLLGF 221
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 346 SFIGSFTYLFKFIEQQFGQTASQANFLLGVITIpTMASGMFLGGYLIKRLK--------LTLLGITKFVFFTTTMAYVFY 417
Cdd:COG2814  222 GFFALFTYLPLYLQEVLGLSASAAGLLLALFGL-GGVLGALLAGRLADRFGrrrllligLLLLALGLLLLALAGSLWLLL 300

                 ....*.
gi 568944218 418 LSYFLL 423
Cdd:COG2814  301 LALFLL 306
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
455-503 4.66e-14

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 66.75  E-value: 4.66e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568944218  455 NSDCICDKNQWEPVCGENGVTYISPC---LAGCKSFRGDKKLMNieFYDCSC 503
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVKEEKV--KYDGSC 50
MFS_1 pfam07690
Major Facilitator Superfamily;
27-422 2.23e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 62.82  E-value: 2.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218   27 IFLAALSFSYICKALGGVIMKSsitqierrFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGS 106
Cdd:pfam07690   5 AFLAALGRSLLGPALPLLLAED--------LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  107 ILTALPHffmgyyryatendisslhnstltclvnqttsltgtspeimekgcekgsnsyTWIYVLMGNMLRGIGETPIVPL 186
Cdd:pfam07690  77 LLLLFAS---------------------------------------------------SLWLLLVLRVLQGLGAGALFPA 105
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  187 GVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYvdvgyvdlrsvritpqDARWVgawwlgFIVNGLLCII 266
Cdd:pfam07690 106 ALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF----------------GWRAA------FLILAILSLL 163
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  267 CSIPFFFLPKIPKRSQKerknsaslhvlktdedknpvtnpttqeKQAPANLTGFLWSLRSILTNEqyVIFLILTLLQISS 346
Cdd:pfam07690 164 AAVLLLLPRPPPESKRP---------------------------KPAEEARLSLIVAWKALLRDP--VLWLLLALLLFGF 214
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568944218  347 FIGSFTYLFKFIEQQFGQTASQANFLLGVITIpTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFL 422
Cdd:pfam07690 215 AFFGLLTYLPLYQEVLGLSALLAGLLLGLGGL-LGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTL 289
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
460-503 1.00e-09

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 54.20  E-value: 1.00e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 568944218 460 CDKNQwEPVCGENGVTYISPCLAGCKSFRGDKKLMNieFYDCSC 503
Cdd:cd00104    1 CPKEY-DPVCGSDGKTYSNECHLGCAACRSGRSITV--AHNGPC 41
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
53-424 1.50e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 57.25  E-value: 1.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  53 IERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGSILtalphffmgyyryatendisslhn 132
Cdd:cd17328   25 IQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL------------------------ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 133 stltclvnqttsltgtspeimekgcekGSNSYTWIYVLMGNMLRGIGETPIVPLGVSYIDDFAKEGNSSMYLGTLHTIAM 212
Cdd:cd17328   81 ---------------------------SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIP 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 213 IGPILGFIMSSVFAKLyvdvgyvdlrsvritpqdarwVGAWWLGFIVNGLLCIICSIPFFFLPKIPKRSQKERKNSASLH 292
Cdd:cd17328  134 LGSGLGYVVGGLVAQA---------------------TGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKST 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 293 VLKTDEDknpvtnpttqekqapanltgfLWSLRSILTneqyviFLILTL-LQISSF-IGSFTY----LFKFIEQQFGQTA 366
Cdd:cd17328  193 ATSFLAD---------------------LKALAKNPS------FILSTLgFTAVSFvTGALAFwaptFFLRAFGVGDLSS 245
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 367 SQANFLLGVITIPTMASGMFLGGYLIKRLK------------LTLLGITKFVFFTTTMAYVFYLSYFLLI 424
Cdd:cd17328  246 ADVGLIFGAITCIAGVLGVLLGGILADRLRrktpradplvcaVGLLAAAPFLFLALVLALSNLLLAWVLL 315
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
161-435 1.46e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 54.12  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 161 SNSYTWIYVLMgnMLRGIGETPIVPLGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYvdvGYvdlrsv 240
Cdd:cd17325   81 ATSYWQLLLAR--FLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL---GY------ 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 241 ritpqdaRWVgawwlgFIVNGLLCIICSIPFFFLPKIPKRSQKERKNSASLhvlktdedknpvtnpttqekqapanltgF 320
Cdd:cd17325  150 -------RAP------FLVCAALALLALVLALLLLPEPRPPPNKRAVSAAR----------------------------L 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 321 LWSLRSILTNEQYVIFLILTLLQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASgMFLGGYLIKRLKLTLL 400
Cdd:cd17325  189 RSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALS-QPPAGKLSDRIGRKPL 267
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568944218 401 GITKFVFFTTTMAYVFYLSYFLLICENKAFAGLTL 435
Cdd:cd17325  268 ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGL 302
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
25-416 1.15e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.39  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  25 FRIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGI 104
Cdd:COG0738    6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 105 GSILTALphffmgyyryatendisslhnstltclvnqttsltgtspeimekgcekgsnSYTWIYVLMGNMLRGIGETPIV 184
Cdd:COG0738   86 GLLLFAL---------------------------------------------------APSYPLLLLALFLLGLGLGLLD 114
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 185 PLGVSYIDDFAKEGNSSMyLGTLHTIAMIGPILGFIMSSVFAKLYVDVgyvdlrsvritpqdarwvgAWWLGFIVNGLLC 264
Cdd:COG0738  115 VAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLSL-------------------SWHLPYLILAVLL 174
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 265 IICSIPFFFLpKIPKRSQKERKNSASLHvlktdedknpvtnpttqekqapanltgflwSLRSILTNEQYVIFLILTLLQI 344
Cdd:COG0738  175 LLLALLFLRS-KLPEIEEEEEEAAGSAA------------------------------SLKSLLKNPRLLLGGLAIFLYV 223
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 345 SSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIpTMASGMFLGGYLIKRLK----------LTLLGITKFVFFTTTMAY 414
Cdd:COG0738  224 GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWG-GMTIGRFLGGFLLKRFGpvrllrlsalLAAVGLLLALLAPGPWLA 302

                 ..
gi 568944218 415 VF 416
Cdd:COG0738  303 LI 304
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
307-443 8.45e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.66  E-value: 8.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 307 TTQEKQAPAN-LTGFLWSLRSILTNEQYVIFLILTLLQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMAsGM 385
Cdd:COG2211  203 GTKERPVPEEeKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALL-GA 281
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568944218 386 FLGGYLIKRL---KLTLLGITKFVFFTTTMAYVFYLSYFLLICenkAFAGLTLTYDGMNPV 443
Cdd:COG2211  282 PLWPRLAKRFgkkKAFIIGLLLAALGLLLLFFLGPGNLWLLLV---LAALAGIGLGAILVL 339
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
205-425 1.56e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 44.56  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 205 GTLHTIAMIGPILGFIMSSVFAKLYVDvGYVDLrsvritpqdarwvgaWWLGFIVNGLLCIICSIPFFFLPKIPKR--SQ 282
Cdd:cd17357  140 GALGSLTQIGVTLGILLGQVFGLPSVL-GTETL---------------WPYLLFFPGIPALLQLAALPFFPESPKFllIS 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 283 KERKNSA--SLHVLKTDED-KNPVTNPTTQEKQAPANLTGFlwSLRSILTNEQYVIFLILTLL-----QISSFIGSFTYL 354
Cdd:cd17357  204 KGDEEEAekSLKFLRGIEDdVDQELEEIKKESEQMGDQKQV--SLMQLLRDPSLRLPLLLVLVvsasqQFSGINAIFFYS 281
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568944218 355 FKFIEQ--QFGQTASQANFLLGVI-TIPTMASGMFLGGY-----LIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLIC 425
Cdd:cd17357  282 TFIFENagFSPQLAEWANLGIGIVnVLSTIVGPFLIEKVgrrplLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVA 360
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
29-425 3.05e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 43.71  E-value: 3.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  29 LAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGSIL 108
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 109 TALphffmgyyryatendisslhnstltclvnqttsltgtspeimekgcekgSNSYTWIyvLMGNMLRGIGETPIVPLGV 188
Cdd:cd17474   81 CGL-------------------------------------------------SDSFALL--LAGRALQGIGAAGLGPLAL 109
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 189 SYIDDFAKEGNSSMYLGTLH---TIAM-IGPILGFIMSSVfaklyvdvgyvdlrsvritpqdarwvgAWWLGFIVNGLLC 264
Cdd:cd17474  110 TLIGDLFEGGERAKAMGLYEaalGLGIaVGPLLGGLLAAI---------------------------SWRYPFFLLAALI 162
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 265 IICSIPFFFLPKIPKRSQKERKNSASLHVLKtdedknpvtnpttqekqapanltgflwslrsILTNEQYVIFLILTLLQI 344
Cdd:cd17474  163 PVAFLAILFLLPEPKEKAKSSSATKLRDLKK-------------------------------ALRGRGLLTFLVSAFLYF 211
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 345 SSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLS--YFL 422
Cdd:cd17474  212 FLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPslALL 291

                 ...
gi 568944218 423 LIC 425
Cdd:cd17474  292 LIA 294
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
29-423 5.19e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.93  E-value: 5.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  29 LAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGSIL 108
Cdd:COG2271   12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 109 TALphffmgyyryatendisslhnstltclvnqttsltgtspeimekgcekgSNSYTWIYVLMgnMLRGIGETPIVPLGV 188
Cdd:COG2271   92 FGF-------------------------------------------------ATSFWQLLLLR--FLLGLGEAGFFPAAL 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 189 SYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYvdvgyvdlrsvritpqdarwvgAWWLGFIVNGLLCIICS 268
Cdd:COG2271  121 KLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF----------------------GWRAAFLILGLPGLLLA 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 269 IPFFFLpkipkrsqkerknsaslhvlktdedknpvtnpttqekqapanltgflwslrsiltneqyvIFLILTLLQISSFi 348
Cdd:COG2271  179 LLRFWL------------------------------------------------------------LALAYFLVYFALY- 197
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 349 GSFTYLFKFIEQQFGQTASQANFLLGVITIPTMAsGMFLGGYLIKRLK----------LTLLGITKFVFFTTTMAYVFYL 418
Cdd:COG2271  198 GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIV-GSLLGGWLSDRLGrrrklvlaigLLLAALALLLLALLPSPALAIA 276

                 ....*
gi 568944218 419 SYFLL 423
Cdd:COG2271  277 LLFLA 281
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
457-493 6.16e-04

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 38.04  E-value: 6.16e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568944218   457 DCICDKNqWEPVCGENGVTYISPCLAGCKSFRGDKKL 493
Cdd:smart00280   3 PEACPRE-YDPVCGSDGVTYSNECHLCKAACESGKSI 38
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
50-425 7.03e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 42.54  E-value: 7.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218  50 ITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGSILTALphffmgyyryatendiss 129
Cdd:cd17324   22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL------------------ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 130 lhnstltclvnqttsltgtspeimekgcekgSNSYTWIyvLMGNMLRGIGETPIVPLGVSYIDDFAKEGNSSMYLGTLHT 209
Cdd:cd17324   84 -------------------------------APSFALL--LLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFS 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 210 IAMIGPILGFIMSSVFAKLYvdvGYvdlrsvritpqdaRWVgawwlgFIVNGLLCIICSIPF-FFLPKIPKrsqkerKNS 288
Cdd:cd17324  131 GLTLGLVLGRPLGGLLGQLL---GW-------------RAA------FLAIAVLALLAALLLwRLLPSLPP------KKP 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 289 ASLHVLKtdedknpvtnpttqekqapanltgflwSLRSILTNEQYVIFLILTLLQISSFIGSFTYLFKFIEQQFGQTASQ 368
Cdd:cd17324  183 GSLGLLS---------------------------SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSA 235
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568944218 369 ANFLLGVITIpTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLIC 425
Cdd:cd17324  236 IIGLLLLFGV-AGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLL 291
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
203-424 2.22e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 41.05  E-value: 2.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 203 YLGTLHTIAMI-GPILGFIMSSVFAklyvdvgyvdlrsvritPQDARWVGAwwlgfiVNGLLCIICSipFFFLPKIPKRS 281
Cdd:cd17331  126 RLGLSYGIGMVvGSFLGGLLTKKFG-----------------EQAAALVAA------VGSLLSIVLV--ILLIPSNTKSK 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 282 QKERKnsaslhvlKTDEDKNPVTNPTTqekqapanlTGFLWSLRSILtneQYVIFLILTLLQISSFIGSFTYlfkFIEQQ 361
Cdd:cd17331  181 REKEA--------KESASPPSVFNLKE---------ILRLLRLPGVA---FLLLVKLLSGLPIGMFQSMFSL---VAMDF 237
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568944218 362 FGQTASQANFLLGVITIPTMASGMFLGGYLIKRL---KLTLLGITKFVFFTTTMAYVFYLSYFLLI 424
Cdd:cd17331  238 FGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFgerSLLKLSVALLAIGYLLLAFVTTVWQLLVL 303
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
249-423 2.37e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 40.68  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 249 WVGAWWlGFIVNGLLCIICSIPFFFLPKIPKRSQKERKNSaslhvlktdedknpvtnpttqekqapanLTGFLWSLRSIL 328
Cdd:cd06173  154 LLGPGG-AFAINALSFLLSALLLLFIRRPPPAAPGESSSL----------------------------LLRDLREGLRYL 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 329 TNEQYVIFLILTLLQISSFIGSFTYLF-KFIEQQFGQTASQANFLLGVITIptmasGMFLGGYLIKRLK----------- 396
Cdd:cd06173  205 RRSPLLRLLLLALALFALLGGALTVLLpLLAKEVLGGGAAGYGLLLAAFGV-----GALLGALLLGRLSkrrrrgrllli 279
                        170       180
                 ....*....|....*....|....*...
gi 568944218 397 -LTLLGITKFVFFTTTMAYVFYLSYFLL 423
Cdd:cd06173  280 gALLLGLALLVLGLSPSLWLLLAALFLL 307
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
321-424 3.60e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.25  E-value: 3.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944218 321 LWSLRSILTNEQYVIFLILTLLQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMAsGMFLGGYLIKRLK---- 396
Cdd:COG2223  195 LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGAL-GRPLGGWLSDRIGgrrv 273
                         90       100       110
                 ....*....|....*....|....*....|..
gi 568944218 397 ----LTLLGITKFVFFTTTMAYVFYLSYFLLI 424
Cdd:COG2223  274 llivFALMALGLLLLALALGSLWLFLVLFLLL 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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