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Conserved domains on  [gi|568928203|ref|XP_006502720|]
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zinc finger protein Rlf isoform X1 [Mus musculus]

Protein Classification

zinc finger family protein( domain architecture ID 706824)

zinc finger family protein may be involved in transcriptional regulation; similar to Schizosaccharomyces pombe E3 ubiquitin-protein ligase hel2, which that plays a key role in the ribosome quality control (RQC), and Homo sapiens histone H4 transcription factor

Gene Ontology:  GO:0008270
PubMed:  11179890

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG5236 super family cl28715
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
426-602 7.25e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5236:

Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 44.24  E-value: 7.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928203  426 QARGESHEYVTFSKLEDRRLQDRDL--YPCPGTDCSRVFKQFKYLSVHLKAEHQnndenaKHYLDMKNRREKCTYCRRHF 503
Cdd:COG5236   125 QWKGREEKVGIFYEGEDVRDEMEDLlsFKCPKSKCHRRCGSLKELKKHYKAQHG------FVLCSECIGNKKDFWNEIRL 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928203  504 MSAFHLREHEQVHCGPQPY----MCvsIDCYARFGSVNELLNH-KQKHDdlryKCELngCNIV-------FSDLGQLYhh 571
Cdd:COG5236   199 FRSSTLRDHKNGGLEEEGFkghpLC--IFCKIYFYDDDELRRHcRLRHE----ACHI--CDMVgpiryqyFKSYEDLE-- 268
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 568928203  572 eaQHFRDASYTCNVLGCK--KFYYSK--IEYQNHL 602
Cdd:COG5236   269 --AHFRNAHYCCTFQTCRvgKCYVFPyhTELLEHL 301
 
Name Accession Description Interval E-value
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
426-602 7.25e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 44.24  E-value: 7.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928203  426 QARGESHEYVTFSKLEDRRLQDRDL--YPCPGTDCSRVFKQFKYLSVHLKAEHQnndenaKHYLDMKNRREKCTYCRRHF 503
Cdd:COG5236   125 QWKGREEKVGIFYEGEDVRDEMEDLlsFKCPKSKCHRRCGSLKELKKHYKAQHG------FVLCSECIGNKKDFWNEIRL 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928203  504 MSAFHLREHEQVHCGPQPY----MCvsIDCYARFGSVNELLNH-KQKHDdlryKCELngCNIV-------FSDLGQLYhh 571
Cdd:COG5236   199 FRSSTLRDHKNGGLEEEGFkghpLC--IFCKIYFYDDDELRRHcRLRHE----ACHI--CDMVgpiryqyFKSYEDLE-- 268
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 568928203  572 eaQHFRDASYTCNVLGCK--KFYYSK--IEYQNHL 602
Cdd:COG5236   269 --AHFRNAHYCCTFQTCRvgKCYVFPyhTELLEHL 301
 
Name Accession Description Interval E-value
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
426-602 7.25e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 44.24  E-value: 7.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928203  426 QARGESHEYVTFSKLEDRRLQDRDL--YPCPGTDCSRVFKQFKYLSVHLKAEHQnndenaKHYLDMKNRREKCTYCRRHF 503
Cdd:COG5236   125 QWKGREEKVGIFYEGEDVRDEMEDLlsFKCPKSKCHRRCGSLKELKKHYKAQHG------FVLCSECIGNKKDFWNEIRL 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928203  504 MSAFHLREHEQVHCGPQPY----MCvsIDCYARFGSVNELLNH-KQKHDdlryKCELngCNIV-------FSDLGQLYhh 571
Cdd:COG5236   199 FRSSTLRDHKNGGLEEEGFkghpLC--IFCKIYFYDDDELRRHcRLRHE----ACHI--CDMVgpiryqyFKSYEDLE-- 268
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 568928203  572 eaQHFRDASYTCNVLGCK--KFYYSK--IEYQNHL 602
Cdd:COG5236   269 --AHFRNAHYCCTFQTCRvgKCYVFPyhTELLEHL 301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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