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Conserved domains on  [gi|568911966|ref|XP_006497298|]
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membrane cofactor protein isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 64-296 1.13e-42

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 148.65  E-value: 1.13e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966  64 YAVGEKIEYKCKKGYLYLSPYLMIATCEPNhTWVPISDagCIKVQCTMLQDPSFGKVYYidGSFSWGARAKFTCMEGYYV 143
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQLDI--GGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966 144 VGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDptpgpDKFSLVGTSMIFCAG 223
Cdd:PHA02927 119 IGESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCN-----SGYSLIGNSGVLCSG 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568911966 224 hNTWSNsPPECKVVKCPNPVLQNGRLISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLK 296
Cdd:PHA02927 193 -GEWSD-PPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 64-296 1.13e-42

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 148.65  E-value: 1.13e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966  64 YAVGEKIEYKCKKGYLYLSPYLMIATCEPNhTWVPISDagCIKVQCTMLQDPSFGKVYYidGSFSWGARAKFTCMEGYYV 143
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQLDI--GGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966 144 VGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDptpgpDKFSLVGTSMIFCAG 223
Cdd:PHA02927 119 IGESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCN-----SGYSLIGNSGVLCSG 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568911966 224 hNTWSNsPPECKVVKCPNPVLQNGRLISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLK 296
Cdd:PHA02927 193 -GEWSD-PPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
Sushi pfam00084
Sushi repeat (SCR repeat);
109-168 5.76e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.90  E-value: 5.76e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966  109 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGddeaYWNGYPPHC 168
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDG----TWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 239-294 1.10e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.32  E-value: 1.10e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911966 239 CPNP-VLQNGRLISGAGEiFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 294
Cdd:cd00033    1 CPPPpVPENGTVTGSKGS-YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 239-294 1.24e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.68  E-value: 1.24e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911966   239 CPNP-VLQNGRlISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 294
Cdd:smart00032   1 CPPPpDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 64-296 1.13e-42

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 148.65  E-value: 1.13e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966  64 YAVGEKIEYKCKKGYLYLSPYLMIATCEPNhTWVPISDagCIKVQCTMLQDPSFGKVYYidGSFSWGARAKFTCMEGYYV 143
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQLDI--GGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966 144 VGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDptpgpDKFSLVGTSMIFCAG 223
Cdd:PHA02927 119 IGESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCN-----SGYSLIGNSGVLCSG 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568911966 224 hNTWSNsPPECKVVKCPNPVLQNGRLISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLK 296
Cdd:PHA02927 193 -GEWSD-PPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
PHA02639 PHA02639
EEV host range protein; Provisional
 103-309 2.45e-23

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 97.81  E-value: 2.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966 103 GCIKVQCTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVlKGDDEAYWNGYPPHCEKIYCLPPPKIKNG 182
Cdd:PHA02639  16 GVKSIYCDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCI-KDKNNAIWSNKAPFCMLKECNDPPSIING 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966 183 ThTLTDINVFKYHEAVSYSCDPTPGPdKFSLVGTSMIFCAGHNTWSNSPPECKVVKCPNPVLQNGrLISG--AGEIFSYQ 260
Cdd:PHA02639  95 K-IYNKREMYKVGDEIYYVCNEHKGV-QYSLVGNEKITCIQDKSWKPDPPICKMINCRFPALQNG-YINGipSNKKFYYK 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568911966 261 STVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLKDAWIIALIVITSI 309
Cdd:PHA02639 172 TRVGFSCKSGFDLVGEKYSTCNINATWFPSIPTCVRNKPIDDIIYLKPV 220
PHA02817 PHA02817
EEV Host range protein; Provisional
 168-306 7.31e-19

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 84.22  E-value: 7.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966 168 CEKIYCLPPPKIKNGtHTLTDINVFKYHEAVSYSCDPTPGPDKFSLVGTSMIFCAGHNTWSNSPPECKVVKCPNPVLQNG 247
Cdd:PHA02817  19 CDLNKCCYPPSIKNG-YIYNKKTEYNIGSNVTFFCGNNTRGVRYTLVGEKNIICEKDGKWNKEFPVCKIIRCRFPALQNG 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568911966 248 rLISG--AGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLKDAWIIALIVI 306
Cdd:PHA02817  98 -FVNGipDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPICSRDNITYNKIYI 157
PHA02831 PHA02831
EEV host range protein; Provisional
 170-298 3.92e-16

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 77.34  E-value: 3.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966 170 KIYCLPPPKIKNGtHTLTDINVFKYHEAVSYSCDPTPgPDKFSLVGTSMIFCAgHNTWSNSPPECKVVKCPNPVLQNGRL 249
Cdd:PHA02831  75 KRNCKDPVTILNG-YIKNKKDQYSFGDSVTYACKVNK-LEKYSIVGNETVKCI-NKQWVPKYPVCKLIRCKYPALQNGFL 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568911966 250 ISGAGEiFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLKDA 298
Cdd:PHA02831 152 NVFEKK-FYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKCVKDK 199
Sushi pfam00084
Sushi repeat (SCR repeat);
109-168 5.76e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.90  E-value: 5.76e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966  109 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGddeaYWNGYPPHC 168
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDG----TWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 239-294 1.10e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.32  E-value: 1.10e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911966 239 CPNP-VLQNGRLISGAGEiFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 294
Cdd:cd00033    1 CPPPpVPENGTVTGSKGS-YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
239-294 1.68e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 55.97  E-value: 1.68e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911966  239 CPNP-VLQNGRlISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 294
Cdd:pfam00084   1 CPPPpDIPNGK-VSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 239-294 1.24e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.68  E-value: 1.24e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911966   239 CPNP-VLQNGRlISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 294
Cdd:smart00032   1 CPPPpDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 173-235 6.32e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 51.69  E-value: 6.32e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568911966 173 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPECK 235
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNE-----GYTLVGSSTITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
173-234 4.00e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.42  E-value: 4.00e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568911966  173 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPTpgpdkFSLVGTSMIFCAGHNTWSNSPPEC 234
Cdd:pfam00084   1 CPPPPDIPNGKVSATK-NEYNYGASVSYECDPG-----YRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 109-169 6.73e-08

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 48.61  E-value: 6.73e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568911966 109 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDdeayWNGYPPHCE 169
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG----WSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 173-234 1.71e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.52  E-value: 1.71e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568911966   173 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPEC 234
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDP-----GYTLIGSSTITCLENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 109-168 8.90e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 45.60  E-value: 8.90e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966   109 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDdeayWNGYPPHC 168
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT----WSPPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 104-234 1.14e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 45.70  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966 104 CIKVQCTMLQDPSFGKVYYIDGSFSWGARAKFTCMEG-----YYVVGMSVLHCvlkgDDEAYWNGYPPHCEKIYClPPPK 178
Cdd:PHA02817  19 CDLNKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIIC----EKDGKWNKEFPVCKIIRC-RFPA 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911966 179 IKNG-THTLTDINVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPEC 234
Cdd:PHA02817  94 LQNGfVNGIPDSKKFYYESEVSFSCKP-----GFVLIGTKYSVCGINSSWIPKVPIC 145
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 192-296 1.43e-05

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 46.23  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911966 192 FKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGhNTWsNSPPECKVvKCPNPVLQNGrLISGAgeIFSYQSTVMFECLQGF 271
Cdd:PHA02954 147 YSFGEHITINCDV-----GYEVIGASYISCTA-NSW-NVIPSCQQ-KCDIPSLSNG-LISGS--TFSIGGVIHLSCKSGF 215

                         90       100
                 ....*....|....*....|....*
gi 568911966 272 YMEGSSMVICsANNSWEPSIPKCLK 296
Cdd:PHA02954 216 TLTGSPSSTC-IDGKWNPVLPICVR 239
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 45-98 1.44e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 36.29  E-value: 1.44e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568911966  45 CELPRPFEAMELKGTpKLFYAVGEKIEYKCKKGYLYLSPylMIATCEPNHTWVP 98
Cdd:cd00033    1 CPPPPVPENGTVTGS-KGSYSYGSTVTYSCNEGYTLVGS--STITCTENGGWSP 51
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 45-98 7.81e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 34.42  E-value: 7.81e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568911966    45 CELPRPFEAMELKGTPKLFYaVGEKIEYKCKKGYLYLSPYlmIATCEPNHTWVP 98
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYS-YGDTVTYSCDPGYTLIGSS--TITCLENGTWSP 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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