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Conserved domains on  [gi|2217309912|ref|XP_005257977|]
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ankyrin repeat domain-containing protein 13B isoform X1 [Homo sapiens]

Protein Classification

GPCR_chapero_1 domain-containing protein( domain architecture ID 12790908)

GPCR_chapero_1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GPCR_chapero_1 pfam11904
GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together ...
 305-643 2.27e-135

GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.


:

Pssm-ID: 463391  Cd Length: 298  Bit Score: 402.40  E-value: 2.27e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 305 RVDTTLLGFDHMTWQRGNRSFVFRGQDTS-AVVMEIDHDRRVVYTETLALAGQDRElllaaaqpTEEQVLSRLTAPVVTT 383
Cdd:pfam11904   1 RADTTLLGFDGFKWQRGDQSFLFLGDGDSpGSLLELDHDEKEVQLEGAGAEASEEE--------VEEEVAARLQTPIVRP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 384 QLDTKNISFERNKTGilgW-RSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVK-------GCKTPLQSFLGI 455
Cdd:pfam11904  73 GIDVTKISFERNKSG---WrRQEKTEMVGGYKAKVYDASNVELSTKSRTEHLSEEEKAKLKsaleppeGSRTPLQSFLGI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 456 AEQHGGPQNGTLITQTLSQANPTAITAEEYFNPnfelgnrdmgrPMELTTKTQnvpyplgsgggRFKAKLWLCEEHPLSL 535
Cdd:pfam11904 150 AEEEKGWFGKTREESEAPPTNPTALTPEEYFDP-----------PKEESEKKK-----------GFKATLWLSEDFPLSL 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 536 cEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDePVPSVRGSPSSETPSPGsdss 615
Cdd:pfam11904 208 -EQLLPILDLLANKVKHFRRLREFITLKLPPGFPVKIEIPVFPTVNARITFTKFEELD-PVEEFSTPIKSPERGSP---- 281

                         330       340
                  ....*....|....*....|....*...
gi 2217309912 616 svsssssttscRGCEISPALFEAPRGYS 643
Cdd:pfam11904 282 -----------SSCEIDDDPFEIPSGYT 298
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
146-245 5.04e-16

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.23  E-value: 5.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 146 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGqVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWT 225
Cdd:COG0666    77 GADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                          90       100
                  ....*....|....*....|
gi 2217309912 226 VLQEAVSTRDLELVQLVLRY 245
Cdd:COG0666   156 PLHLAAANGNLEIVKLLLEA 175
 
Name Accession Description Interval E-value
GPCR_chapero_1 pfam11904
GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together ...
 305-643 2.27e-135

GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.


Pssm-ID: 463391  Cd Length: 298  Bit Score: 402.40  E-value: 2.27e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 305 RVDTTLLGFDHMTWQRGNRSFVFRGQDTS-AVVMEIDHDRRVVYTETLALAGQDRElllaaaqpTEEQVLSRLTAPVVTT 383
Cdd:pfam11904   1 RADTTLLGFDGFKWQRGDQSFLFLGDGDSpGSLLELDHDEKEVQLEGAGAEASEEE--------VEEEVAARLQTPIVRP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 384 QLDTKNISFERNKTGilgW-RSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVK-------GCKTPLQSFLGI 455
Cdd:pfam11904  73 GIDVTKISFERNKSG---WrRQEKTEMVGGYKAKVYDASNVELSTKSRTEHLSEEEKAKLKsaleppeGSRTPLQSFLGI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 456 AEQHGGPQNGTLITQTLSQANPTAITAEEYFNPnfelgnrdmgrPMELTTKTQnvpyplgsgggRFKAKLWLCEEHPLSL 535
Cdd:pfam11904 150 AEEEKGWFGKTREESEAPPTNPTALTPEEYFDP-----------PKEESEKKK-----------GFKATLWLSEDFPLSL 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 536 cEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDePVPSVRGSPSSETPSPGsdss 615
Cdd:pfam11904 208 -EQLLPILDLLANKVKHFRRLREFITLKLPPGFPVKIEIPVFPTVNARITFTKFEELD-PVEEFSTPIKSPERGSP---- 281

                         330       340
                  ....*....|....*....|....*...
gi 2217309912 616 svsssssttscRGCEISPALFEAPRGYS 643
Cdd:pfam11904 282 -----------SSCEIDDDPFEIPSGYT 298
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
146-245 5.04e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.23  E-value: 5.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 146 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGqVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWT 225
Cdd:COG0666    77 GADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                          90       100
                  ....*....|....*....|
gi 2217309912 226 VLQEAVSTRDLELVQLVLRY 245
Cdd:COG0666   156 PLHLAAANGNLEIVKLLLEA 175
Ank_2 pfam12796
Ankyrin repeats (3 copies);
160-243 1.55e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 1.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 160 LHYLVWHNrHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAdvGRENRSGWTVLQEAVSTRDLELV 239
Cdd:pfam12796   1 LHLAAKNG-NLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIV 77


                  ....
gi 2217309912 240 QLVL 243
Cdd:pfam12796  78 KLLL 81
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 179-245 1.39e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 58.37  E-value: 1.39e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217309912 179 GQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 245
Cdd:PTZ00322  104 GGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 189-216 6.99e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 6.99e-05
                           10        20
                   ....*....|....*....|....*...
gi 2217309912  189 RGRTPLHLATTLGHLECARVLLAHGADV 216
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
 
Name Accession Description Interval E-value
GPCR_chapero_1 pfam11904
GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together ...
 305-643 2.27e-135

GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.


Pssm-ID: 463391  Cd Length: 298  Bit Score: 402.40  E-value: 2.27e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 305 RVDTTLLGFDHMTWQRGNRSFVFRGQDTS-AVVMEIDHDRRVVYTETLALAGQDRElllaaaqpTEEQVLSRLTAPVVTT 383
Cdd:pfam11904   1 RADTTLLGFDGFKWQRGDQSFLFLGDGDSpGSLLELDHDEKEVQLEGAGAEASEEE--------VEEEVAARLQTPIVRP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 384 QLDTKNISFERNKTGilgW-RSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVK-------GCKTPLQSFLGI 455
Cdd:pfam11904  73 GIDVTKISFERNKSG---WrRQEKTEMVGGYKAKVYDASNVELSTKSRTEHLSEEEKAKLKsaleppeGSRTPLQSFLGI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 456 AEQHGGPQNGTLITQTLSQANPTAITAEEYFNPnfelgnrdmgrPMELTTKTQnvpyplgsgggRFKAKLWLCEEHPLSL 535
Cdd:pfam11904 150 AEEEKGWFGKTREESEAPPTNPTALTPEEYFDP-----------PKEESEKKK-----------GFKATLWLSEDFPLSL 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 536 cEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDePVPSVRGSPSSETPSPGsdss 615
Cdd:pfam11904 208 -EQLLPILDLLANKVKHFRRLREFITLKLPPGFPVKIEIPVFPTVNARITFTKFEELD-PVEEFSTPIKSPERGSP---- 281

                         330       340
                  ....*....|....*....|....*...
gi 2217309912 616 svsssssttscRGCEISPALFEAPRGYS 643
Cdd:pfam11904 282 -----------SSCEIDDDPFEIPSGYT 298
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
146-245 5.04e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.23  E-value: 5.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 146 ANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGqVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWT 225
Cdd:COG0666    77 GADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                          90       100
                  ....*....|....*....|
gi 2217309912 226 VLQEAVSTRDLELVQLVLRY 245
Cdd:COG0666   156 PLHLAAANGNLEIVKLLLEA 175
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
152-245 1.36e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.07  E-value: 1.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 152 KGPEGKYPLHYLVWHNRHRELEKEVRAGqVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAV 231
Cdd:COG0666   116 RDKDGETPLHLAAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAA 194

                          90
                  ....*....|....
gi 2217309912 232 STRDLELVQLVLRY 245
Cdd:COG0666   195 ENGHLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
152-246 2.76e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 74.22  E-value: 2.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 152 KGPEGKYPLHYLVWHNrHRELEKE-VRAGqVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEA 230
Cdd:COG0666   149 QDNDGNTPLHLAAANG-NLEIVKLlLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLA 226

                          90
                  ....*....|....*.
gi 2217309912 231 VSTRDLELVQLVLRYR 246
Cdd:COG0666   227 AENGNLEIVKLLLEAG 242
Ank_2 pfam12796
Ankyrin repeats (3 copies);
160-243 1.55e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 1.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 160 LHYLVWHNrHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGAdvGRENRSGWTVLQEAVSTRDLELV 239
Cdd:pfam12796   1 LHLAAKNG-NLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIV 77


                  ....
gi 2217309912 240 QLVL 243
Cdd:pfam12796  78 KLLL 81
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
138-245 9.38e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.43  E-value: 9.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 138 HEERAMIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVG 217
Cdd:COG0666    35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN 114

                          90       100
                  ....*....|....*....|....*...
gi 2217309912 218 RENRSGWTVLQEAVSTRDLELVQLVLRY 245
Cdd:COG0666   115 ARDKDGETPLHLAAYNGNLEIVKLLLEA 142
Ank_4 pfam13637
Ankyrin repeats (many copies);
190-243 6.67e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 6.67e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217309912 190 GRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVL 243
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
176-230 9.95e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 51.96  E-value: 9.95e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217309912 176 VRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEA 230
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 179-245 1.39e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 58.37  E-value: 1.39e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217309912 179 GQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRY 245
Cdd:PTZ00322  104 GGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
Ank_2 pfam12796
Ankyrin repeats (3 copies);
154-220 6.49e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.88  E-value: 6.49e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217309912 154 PEGKYPLHYLVwHNRHRELekeVRA--GQVDIEqLDPRGRTPLHLATTLGHLECARVLLAHGADVGREN 220
Cdd:pfam12796  28 KNGRTALHLAA-KNGHLEI---VKLllEHADVN-LKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
194-247 8.37e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.50  E-value: 8.37e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217309912 194 LHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRD 247
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
152-246 4.75e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.26  E-value: 4.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 152 KGPEGKYPLHYLVWHNRHRELEKEVRAGqVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAV 231
Cdd:COG0666   182 RDNDGETPLHLAAENGHLEIVKLLLEAG-ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260

                          90
                  ....*....|....*
gi 2217309912 232 STRDLELVQLVLRYR 246
Cdd:COG0666   261 AAGAALIVKLLLLAL 275
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 152-246 4.75e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.07  E-value: 4.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 152 KGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAV 231
Cdd:PHA02875   64 KYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAV 143

                          90
                  ....*....|....*
gi 2217309912 232 STRDLELVQLVLRYR 246
Cdd:PHA02875  144 MMGDIKGIELLIDHK 158
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 172-234 2.67e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.02  E-value: 2.67e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217309912 172 LEKEVRAGQvDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTR 234
Cdd:PLN03192  541 LEELLKAKL-DPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAK 602
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 189-221 2.86e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 44.20  E-value: 2.86e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2217309912 189 RGRTPLHLA-TTLGHLECARVLLAHGADVGRENR 221
Cdd:pfam00023   1 DGNTPLHLAaGRRGNLEIVKLLLSKGADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 189-216 6.99e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 6.99e-05
                           10        20
                   ....*....|....*....|....*...
gi 2217309912  189 RGRTPLHLATTLGHLECARVLLAHGADV 216
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
PHA03095 PHA03095
ankyrin-like protein; Provisional
 132-228 2.01e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.63  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 132 RAPRPRHEE-RAMIPANASAR-KGPEGKYPLHYLVwHNRHRELEKEVR----AGqVDIEQLDPRGRTPLHL----ATTLg 201
Cdd:PHA03095   21 NASNVTVEEvRRLLAAGADVNfRGEYGKTPLHLYL-HYSSEKVKDIVRllleAG-ADVNAPERCGFTPLHLylynATTL- 97

                          90       100
                  ....*....|....*....|....*..
gi 2217309912 202 hlECARVLLAHGADVGRENRSGWTVLQ 228
Cdd:PHA03095   98 --DVIKLLIKAGADVNAKDKVGRTPLH 122
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 189-216 4.02e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 4.02e-04
                          10        20
                  ....*....|....*....|....*...
gi 2217309912 189 RGRTPLHLATTLGHLECARVLLAHGADV 216
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 179-246 9.96e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 42.74  E-value: 9.96e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217309912 179 GQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYR 246
Cdd:PHA02876  167 GGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR 234
PHA03095 PHA03095
ankyrin-like protein; Provisional
 156-244 1.23e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.93  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 156 GKYPLHYLVWHNRHRELEKE-VRAGqVDIEQLDPRGRTPLH--LATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVS 232
Cdd:PHA03095   83 GFTPLHLYLYNATTLDVIKLlIKAG-ADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLK 161

                          90
                  ....*....|....
gi 2217309912 233 TR--DLELVQLVLR 244
Cdd:PHA03095  162 SRnaNVELLRLLID 175
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 181-247 2.46e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.19  E-value: 2.46e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217309912 181 VDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRD 247
Cdd:PHA03100  183 VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
PHA03095 PHA03095
ankyrin-like protein; Provisional
 156-244 2.65e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.16  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 156 GKYPLHYLVWHNRHRE--LEKEVRAGqVDIEQLDPRGRTPLHLATTLG-HLECARvLLAHGADVGRENRSGWTVLQEAVS 232
Cdd:PHA03095  222 GNTPLHSMATGSSCKRslVLPLLIAG-ISINARNRYGQTPLHYAAVFNnPRACRR-LIALGADINAVSSDGNTPLSLMVR 299

                          90
                  ....*....|..
gi 2217309912 233 TRDLELVQLVLR 244
Cdd:PHA03095  300 NNNGRAVRAALA 311
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 157-245 3.15e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.63  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309912 157 KYPLHYLVWHNRHRELEKEVRAGQvDIEQLDPRGRTPLHLATT-LGHLECARVLLAHGADVGRENR-SGWTVLQeaVSTR 234
Cdd:PHA02878  202 NSPLHHAVKHYNKPIVHILLENGA-STDARDKCGNTPLHISVGyCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIK 278

                          90
                  ....*....|.
gi 2217309912 235 DLELVQLVLRY 245
Cdd:PHA02878  279 SERKLKLLLEY 289
PHA02795 PHA02795
ankyrin-like protein; Provisional
 182-244 8.13e-03

ankyrin-like protein; Provisional


Pssm-ID: 165157 [Multi-domain]  Cd Length: 437  Bit Score: 39.59  E-value: 8.13e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217309912 182 DIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAV------STRD--LELVQLVLR 244
Cdd:PHA02795  213 DINQLDAGGRTLLYRAIYAGYIDLVSWLLENGANVNAVMSNGYTCLDVAVdrgsviARREthLKILEILLR 283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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