NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|528513507|ref|XP_005161229|]
View 

intracellular hyaluronan-binding protein 4 isoform X1 [Danio rerio]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
152-254 1.55e-26

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


:

Pssm-ID: 461421  Cd Length: 108  Bit Score: 101.29  E-value: 1.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513507  152 GKREFERHSGSDRsrsvRSEEKRSGSGSRNWGSVRDHMSVIEVASPSEE-----VTENEETQEAVETDGENRPSETEEVI 226
Cdd:pfam04774   1 GKREFDRHSGTGR----GPEEKRDGAGRHNWGTVKDEIEAPEEEEAENEmeknnDAEKEAGEEETDENEEAAAAEEEEKE 76
                          90       100
                  ....*....|....*....|....*....
gi 528513507  227 EV-AMEMTLDEWKALQEQSRPKVELNIRK 254
Cdd:pfam04774  77 PNeDKEMTLDEYKKVQEEKRALPAFNIRK 105
IHABP4_N super family cl24679
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
11-96 5.52e-09

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


The actual alignment was detected with superfamily member pfam16174:

Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 54.03  E-value: 5.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513507   11 EGYGCTVANRFGQLLGDESDPFDILYAA-------------GTEKKQKKKKEEPKKTSTTTKSVKKESQRDRKTILPAGG 77
Cdd:pfam16174   3 ESFGCVVTNRFDQLLDDESDPFDVLREAenkkklqlkikfgEKANKGKGAGPRGGPRGGQARIGRKESQKDRKNDVASGQ 82
                          90
                  ....*....|....*....
gi 528513507   78 GGQVRPGHevVEEPIQRRV 96
Cdd:pfam16174  83 PDKPGGGG--NDEPGERRP 99
 
Name Accession Description Interval E-value
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
152-254 1.55e-26

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


Pssm-ID: 461421  Cd Length: 108  Bit Score: 101.29  E-value: 1.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513507  152 GKREFERHSGSDRsrsvRSEEKRSGSGSRNWGSVRDHMSVIEVASPSEE-----VTENEETQEAVETDGENRPSETEEVI 226
Cdd:pfam04774   1 GKREFDRHSGTGR----GPEEKRDGAGRHNWGTVKDEIEAPEEEEAENEmeknnDAEKEAGEEETDENEEAAAAEEEEKE 76
                          90       100
                  ....*....|....*....|....*....
gi 528513507  227 EV-AMEMTLDEWKALQEQSRPKVELNIRK 254
Cdd:pfam04774  77 PNeDKEMTLDEYKKVQEEKRALPAFNIRK 105
IHABP4_N pfam16174
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
11-96 5.52e-09

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 54.03  E-value: 5.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513507   11 EGYGCTVANRFGQLLGDESDPFDILYAA-------------GTEKKQKKKKEEPKKTSTTTKSVKKESQRDRKTILPAGG 77
Cdd:pfam16174   3 ESFGCVVTNRFDQLLDDESDPFDVLREAenkkklqlkikfgEKANKGKGAGPRGGPRGGQARIGRKESQKDRKNDVASGQ 82
                          90
                  ....*....|....*....
gi 528513507   78 GGQVRPGHevVEEPIQRRV 96
Cdd:pfam16174  83 PDKPGGGG--NDEPGERRP 99
 
Name Accession Description Interval E-value
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
152-254 1.55e-26

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


Pssm-ID: 461421  Cd Length: 108  Bit Score: 101.29  E-value: 1.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513507  152 GKREFERHSGSDRsrsvRSEEKRSGSGSRNWGSVRDHMSVIEVASPSEE-----VTENEETQEAVETDGENRPSETEEVI 226
Cdd:pfam04774   1 GKREFDRHSGTGR----GPEEKRDGAGRHNWGTVKDEIEAPEEEEAENEmeknnDAEKEAGEEETDENEEAAAAEEEEKE 76
                          90       100
                  ....*....|....*....|....*....
gi 528513507  227 EV-AMEMTLDEWKALQEQSRPKVELNIRK 254
Cdd:pfam04774  77 PNeDKEMTLDEYKKVQEEKRALPAFNIRK 105
IHABP4_N pfam16174
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
11-96 5.52e-09

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 54.03  E-value: 5.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528513507   11 EGYGCTVANRFGQLLGDESDPFDILYAA-------------GTEKKQKKKKEEPKKTSTTTKSVKKESQRDRKTILPAGG 77
Cdd:pfam16174   3 ESFGCVVTNRFDQLLDDESDPFDVLREAenkkklqlkikfgEKANKGKGAGPRGGPRGGQARIGRKESQKDRKNDVASGQ 82
                          90
                  ....*....|....*....
gi 528513507   78 GGQVRPGHevVEEPIQRRV 96
Cdd:pfam16174  83 PDKPGGGG--NDEPGERRP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH