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Conserved domains on  [gi|196002313|ref|XP_002111024|]
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uncharacterized protein TRIADDRAFT_54540 [Trichoplax adhaerens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CASP8AP2 cd12202
Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of ...
 978-1041 6.95e-25

Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of Caspase 8-associated protein 2 (CASP8AP2) / GON-4 like proteins. CASP8AP2 (aka Flice-Associated Huge Protein (FLASH)) is implicated in numerous gene regulatory roles including roles in embryogenesis, oncogenesis, down-regulation of replication-dependent histone genes, regulation of Caspase 8 activity at the death-inducing signaling complex (DISC), and as a useful marker in leukemia prognosis. Gon-4 is critical in Caenorhabditis elegans gonadogenesis. Danio rerio GON4 is a regulator of gene expression in hematopoietic development, possibly by repressing expression. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


:

Pssm-ID: 213401  Cd Length: 66  Bit Score: 98.59  E-value: 6.95e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 196002313  978 NHTTTSNGDIVVMWTKDCDREILRACQGGF-SPDIFNTLAMKLNRTESD-VKDRFKALISLYQHSL 1041
Cdd:cd12202     1 NNVIKSKGEKVVLWTRDADRVILTACQEKGaSPKTFAALASKLGKKTPQeVSERFRQLMKLFHKSC 66
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 633-677 3.20e-08

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


:

Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 50.50  E-value: 3.20e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 196002313   633 DLYLQFLETLTGFTSRNLSPKELYDEVQSLLHKYPELLQDFIGFL 677
Cdd:pfam02671    1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 373-417 1.41e-05

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


:

Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 43.32  E-value: 1.41e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 196002313  373 VKFTTAEDSLLAIGLSKFNK-KWNLIHEHLLP--TKTAKQIRIRCKNL 417
Cdd:cd11660     1 RKWTDEEDEALVEGVEKYGVgNWAKILKDYFFvnNRTSVDLKDKWRNL 48
Sin3 super family cl35027
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
573-684 4.62e-05

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


The actual alignment was detected with superfamily member COG5602:

Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 47.60  E-value: 4.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002313  573 LGTAKPRSHYRVSTTGNGNRRV-SNLTGVIQLQPDPLR--------KQRTD-SFASAYLTKVKATLQNDKDLYLQFLETL 642
Cdd:COG5602   218 LSSPPVQSSYYVAPCNHDQRTShPTLPSDSQPEPSAPShmpsdargKHQVDfNQAIIFVNKVKVRFQNNPEMYYDFLDSL 297

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 196002313  643 TGFTSRNLSPKELYDEVQSLLHKYPELLQDFIGFLEPQDAKA 684
Cdd:COG5602   298 RTYQMKQRSIQEVYARVTKLFAEAPDLLEEFKEFLPDSSVSA 339
 
Name Accession Description Interval E-value
CASP8AP2 cd12202
Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of ...
 978-1041 6.95e-25

Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of Caspase 8-associated protein 2 (CASP8AP2) / GON-4 like proteins. CASP8AP2 (aka Flice-Associated Huge Protein (FLASH)) is implicated in numerous gene regulatory roles including roles in embryogenesis, oncogenesis, down-regulation of replication-dependent histone genes, regulation of Caspase 8 activity at the death-inducing signaling complex (DISC), and as a useful marker in leukemia prognosis. Gon-4 is critical in Caenorhabditis elegans gonadogenesis. Danio rerio GON4 is a regulator of gene expression in hematopoietic development, possibly by repressing expression. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213401  Cd Length: 66  Bit Score: 98.59  E-value: 6.95e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 196002313  978 NHTTTSNGDIVVMWTKDCDREILRACQGGF-SPDIFNTLAMKLNRTESD-VKDRFKALISLYQHSL 1041
Cdd:cd12202     1 NNVIKSKGEKVVLWTRDADRVILTACQEKGaSPKTFAALASKLGKKTPQeVSERFRQLMKLFHKSC 66
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 633-677 3.20e-08

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 50.50  E-value: 3.20e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 196002313   633 DLYLQFLETLTGFTSRNLSPKELYDEVQSLLHKYPELLQDFIGFL 677
Cdd:pfam02671    1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 373-417 1.41e-05

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 43.32  E-value: 1.41e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 196002313  373 VKFTTAEDSLLAIGLSKFNK-KWNLIHEHLLP--TKTAKQIRIRCKNL 417
Cdd:cd11660     1 RKWTDEEDEALVEGVEKYGVgNWAKILKDYFFvnNRTSVDLKDKWRNL 48
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
573-684 4.62e-05

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 47.60  E-value: 4.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002313  573 LGTAKPRSHYRVSTTGNGNRRV-SNLTGVIQLQPDPLR--------KQRTD-SFASAYLTKVKATLQNDKDLYLQFLETL 642
Cdd:COG5602   218 LSSPPVQSSYYVAPCNHDQRTShPTLPSDSQPEPSAPShmpsdargKHQVDfNQAIIFVNKVKVRFQNNPEMYYDFLDSL 297

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 196002313  643 TGFTSRNLSPKELYDEVQSLLHKYPELLQDFIGFLEPQDAKA 684
Cdd:COG5602   298 RTYQMKQRSIQEVYARVTKLFAEAPDLLEEFKEFLPDSSVSA 339
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 372-417 1.46e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.18  E-value: 1.46e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 196002313   372 RVKFTTAEDSLLAIGLSKFNKKWNLIHEHlLPTKTAKQIRIRCKNL 417
Cdd:pfam00249    1 RGPWTPEEDELLLEAVEKLGNRWKKIAKL-LPGRTDNQCKNRWQNY 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
372-417 5.05e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 5.05e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 196002313    372 RVKFTTAEDSLLAIGLSKF-NKKWNLIHEHLlPTKTAKQIRIRCKNL 417
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYgKNNWEKIAKEL-PGRTAEQCRERWRNL 46
 
Name Accession Description Interval E-value
CASP8AP2 cd12202
Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of ...
 978-1041 6.95e-25

Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of Caspase 8-associated protein 2 (CASP8AP2) / GON-4 like proteins. CASP8AP2 (aka Flice-Associated Huge Protein (FLASH)) is implicated in numerous gene regulatory roles including roles in embryogenesis, oncogenesis, down-regulation of replication-dependent histone genes, regulation of Caspase 8 activity at the death-inducing signaling complex (DISC), and as a useful marker in leukemia prognosis. Gon-4 is critical in Caenorhabditis elegans gonadogenesis. Danio rerio GON4 is a regulator of gene expression in hematopoietic development, possibly by repressing expression. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213401  Cd Length: 66  Bit Score: 98.59  E-value: 6.95e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 196002313  978 NHTTTSNGDIVVMWTKDCDREILRACQGGF-SPDIFNTLAMKLNRTESD-VKDRFKALISLYQHSL 1041
Cdd:cd12202     1 NNVIKSKGEKVVLWTRDADRVILTACQEKGaSPKTFAALASKLGKKTPQeVSERFRQLMKLFHKSC 66
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 633-677 3.20e-08

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 50.50  E-value: 3.20e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 196002313   633 DLYLQFLETLTGFTSRNLSPKELYDEVQSLLHKYPELLQDFIGFL 677
Cdd:pfam02671    1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 373-417 1.41e-05

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 43.32  E-value: 1.41e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 196002313  373 VKFTTAEDSLLAIGLSKFNK-KWNLIHEHLLP--TKTAKQIRIRCKNL 417
Cdd:cd11660     1 RKWTDEEDEALVEGVEKYGVgNWAKILKDYFFvnNRTSVDLKDKWRNL 48
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
573-684 4.62e-05

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 47.60  E-value: 4.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002313  573 LGTAKPRSHYRVSTTGNGNRRV-SNLTGVIQLQPDPLR--------KQRTD-SFASAYLTKVKATLQNDKDLYLQFLETL 642
Cdd:COG5602   218 LSSPPVQSSYYVAPCNHDQRTShPTLPSDSQPEPSAPShmpsdargKHQVDfNQAIIFVNKVKVRFQNNPEMYYDFLDSL 297

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 196002313  643 TGFTSRNLSPKELYDEVQSLLHKYPELLQDFIGFLEPQDAKA 684
Cdd:COG5602   298 RTYQMKQRSIQEVYARVTKLFAEAPDLLEEFKEFLPDSSVSA 339
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 372-417 1.46e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 40.18  E-value: 1.46e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 196002313   372 RVKFTTAEDSLLAIGLSKFNKKWNLIHEHlLPTKTAKQIRIRCKNL 417
Cdd:pfam00249    1 RGPWTPEEDELLLEAVEKLGNRWKKIAKL-LPGRTDNQCKNRWQNY 45
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
557-679 2.11e-04

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 45.68  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196002313  557 SQAKPATQTFqeNALNLGTAKPRSHYR-----VSTTGNGNRRVSNLTGVIQLQ-------PDPLRKQRTDSFASAYLTKV 624
Cdd:COG5602    61 SYSPESMSSY--GGPMDERSGTRRYYEdveqiLSSLAGDNPDPSTDHGSASNQnmersppPRIPYRPLDVSDALSYLEKV 138

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 196002313  625 KATLQNDKDLYLQFLETLTGFTSRNLSPKELYDEVQSLLHKYPELLQDFIGFLEP 679
Cdd:COG5602   139 KEQFSNRPEIYNNFLDIMKDFKSQAIDTPGVIERVSVLFRGYPHLIEGFNTFLPS 193
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 374-417 3.66e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 36.40  E-value: 3.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 196002313  374 KFTTAEDSLLAIGLSKF-NKKWNLIHEHLlPTKTAKQIRIRCKNL 417
Cdd:cd00167     1 PWTEEEDELLLEAVKKYgKNNWEKIAKEL-PGRTPKQCRERWRNL 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
372-417 5.05e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 5.05e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 196002313    372 RVKFTTAEDSLLAIGLSKF-NKKWNLIHEHLlPTKTAKQIRIRCKNL 417
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYgKNNWEKIAKEL-PGRTAEQCRERWRNL 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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