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Conserved domains on  [gi|123478415|ref|XP_001322370|]
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CCR4-NOT transcription complex subunit 11 family [Trichomonas vaginalis G3]

Protein Classification

CNOT11 family protein( domain architecture ID 12589)

CCR4-NOT transcription complex subunit 11 (CNOT11) family protein is a DUF2363 domain-containing protein; similar to human CNOT11, a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation, and general transcription regulation

Gene Ontology:  GO:0030014

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CNOT11 super family cl10852
CCR4-NOT transcription complex subunit 11; This is a family of unknown function found in ...
 262-385 1.33e-24

CCR4-NOT transcription complex subunit 11; This is a family of unknown function found in eukaryotes. Family members include CNOT 11 a subunit of the CCR4-NOT. CNOT11 was shown to interact with the first amino acids of CNOT1 and with CNOT10 and to be required for the association of CNOT10 with the CCR4-NOT complex.


The actual alignment was detected with superfamily member pfam10155:

Pssm-ID: 401964  Cd Length: 124  Bit Score: 97.29  E-value: 1.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123478415  262 IDNNPNVAKKYIEIWSKK--KPQIFDTIASLPISLSEIEIVKFCSTLPNITQKFVDKWITNGMKTIDTENENSLMA-EAR 338
Cdd:pfam10155   1 IENNPNIAIEILVKLLKSpqKPEYLDVLVSLPVTLHSLEVVNRLTKSVNLPREFLHLYISNCIKSCEEIKDKGSQNrLVR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 123478415  339 MFCRLTSFIIQENANQIgQTVKMDLKSFCLILCSkgLAEAQELFERL 385
Cdd:pfam10155  81 LVCVFLQSLIRNKIIDV-KDLFVELQAFCLEFSR--IKEASALFKLL 124
 
Name Accession Description Interval E-value
CNOT11 pfam10155
CCR4-NOT transcription complex subunit 11; This is a family of unknown function found in ...
 262-385 1.33e-24

CCR4-NOT transcription complex subunit 11; This is a family of unknown function found in eukaryotes. Family members include CNOT 11 a subunit of the CCR4-NOT. CNOT11 was shown to interact with the first amino acids of CNOT1 and with CNOT10 and to be required for the association of CNOT10 with the CCR4-NOT complex.


Pssm-ID: 401964  Cd Length: 124  Bit Score: 97.29  E-value: 1.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123478415  262 IDNNPNVAKKYIEIWSKK--KPQIFDTIASLPISLSEIEIVKFCSTLPNITQKFVDKWITNGMKTIDTENENSLMA-EAR 338
Cdd:pfam10155   1 IENNPNIAIEILVKLLKSpqKPEYLDVLVSLPVTLHSLEVVNRLTKSVNLPREFLHLYISNCIKSCEEIKDKGSQNrLVR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 123478415  339 MFCRLTSFIIQENANQIgQTVKMDLKSFCLILCSkgLAEAQELFERL 385
Cdd:pfam10155  81 LVCVFLQSLIRNKIIDV-KDLFVELQAFCLEFSR--IKEASALFKLL 124
 
Name Accession Description Interval E-value
CNOT11 pfam10155
CCR4-NOT transcription complex subunit 11; This is a family of unknown function found in ...
 262-385 1.33e-24

CCR4-NOT transcription complex subunit 11; This is a family of unknown function found in eukaryotes. Family members include CNOT 11 a subunit of the CCR4-NOT. CNOT11 was shown to interact with the first amino acids of CNOT1 and with CNOT10 and to be required for the association of CNOT10 with the CCR4-NOT complex.


Pssm-ID: 401964  Cd Length: 124  Bit Score: 97.29  E-value: 1.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123478415  262 IDNNPNVAKKYIEIWSKK--KPQIFDTIASLPISLSEIEIVKFCSTLPNITQKFVDKWITNGMKTIDTENENSLMA-EAR 338
Cdd:pfam10155   1 IENNPNIAIEILVKLLKSpqKPEYLDVLVSLPVTLHSLEVVNRLTKSVNLPREFLHLYISNCIKSCEEIKDKGSQNrLVR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 123478415  339 MFCRLTSFIIQENANQIgQTVKMDLKSFCLILCSkgLAEAQELFERL 385
Cdd:pfam10155  81 LVCVFLQSLIRNKIIDV-KDLFVELQAFCLEFSR--IKEASALFKLL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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