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Conserved domains on  [gi|504617299|ref|WP_014804401|]
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alpha/beta hydrolase [Turneriella parva]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 10-294 1.77e-26

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 103.54  E-value: 1.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  10 PKGYFTARDGVQLPWFEYGNlkASHTILFLNGFTCNQYNIAKVVATLGVDYRIVTFDYRGQGLAYRERyKKVSIDAVLDD 89
Cdd:COG0596    2 STPRFVTVDGVRLHYREAGP--DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPA-GGYTLDDLADD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  90 IDALHEHIGRIPVLLFGYSMGCQLAVEWNYRDNTRVIGLVLLlgiygnifdsflntkifapmlnatyhafpflkpilkrt 169
Cdd:COG0596   79 LAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLV-------------------------------------- 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299 170 wrtahrlpfairlalgkgtllnpDRVNEAELRPFLDQlaELDFEYILHMSHAIHHHTNEGQFDRIKAPCLIISGEADLFA 249
Cdd:COG0596  121 -----------------------DEVLAALAEPLRRP--GLAPEALAALLRALARTDLRERLARITVPTLVIWGEKDPIV 175

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 504617299 250 LPQHSERVHQAVAASWYFSIPAGTHNAVLEHSEEITSWIAEFLRE 294
Cdd:COG0596  176 PPALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 10-294 1.77e-26

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 103.54  E-value: 1.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  10 PKGYFTARDGVQLPWFEYGNlkASHTILFLNGFTCNQYNIAKVVATLGVDYRIVTFDYRGQGLAYRERyKKVSIDAVLDD 89
Cdd:COG0596    2 STPRFVTVDGVRLHYREAGP--DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPA-GGYTLDDLADD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  90 IDALHEHIGRIPVLLFGYSMGCQLAVEWNYRDNTRVIGLVLLlgiygnifdsflntkifapmlnatyhafpflkpilkrt 169
Cdd:COG0596   79 LAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLV-------------------------------------- 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299 170 wrtahrlpfairlalgkgtllnpDRVNEAELRPFLDQlaELDFEYILHMSHAIHHHTNEGQFDRIKAPCLIISGEADLFA 249
Cdd:COG0596  121 -----------------------DEVLAALAEPLRRP--GLAPEALAALLRALARTDLRERLARITVPTLVIWGEKDPIV 175

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 504617299 250 LPQHSERVHQAVAASWYFSIPAGTHNAVLEHSEEITSWIAEFLRE 294
Cdd:COG0596  176 PPALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 35-264 3.56e-11

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 61.85  E-value: 3.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299   35 TILFLNGF--TCNQY-NIAKVVATLGvdYRIVTFDYRGQGLAYRERYKKVSIDAVLDDIDALHEHI----GRIPVLLFGY 107
Cdd:pfam12146   6 VVVLVHGLgeHSGRYaHLADALAAQG--FAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIreehPGLPLFLLGH 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  108 SMGCQLAVEWNYRDNTRVIGLVLllgiygnifdsflntkiFAPMLN-ATYHAFPFLKPILKRTWRTAHRLPFAIRLalgK 186
Cdd:pfam12146  84 SMGGLIAALYALRYPDKVDGLIL-----------------SAPALKiKPYLAPPILKLLAKLLGKLFPRLRVPNNL---L 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  187 GTLL--NPDRVNEAELRPFLDQLAELDF--EYILHMSHAihhhtnEGQFDRIKAPCLIISGEADLFALPQHSERVHQAVA 262
Cdd:pfam12146 144 PDSLsrDPEVVAAYAADPLVHGGISARTlyELLDAGERL------LRRAAAITVPLLLLHGGADRVVDPAGSREFYERAG 217


                  ..
gi 504617299  263 AS 264
Cdd:pfam12146 218 ST 219
PRK05855 PRK05855
SDR family oxidoreductase;
14-291 1.39e-04

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 43.05  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  14 FTARDGVQLPWFEYGNLKAShTILFLNGFTCNQYNIAKVVATLGVDYRIVTFDYRGQGL--------AYR-ERYKKvSID 84
Cdd:PRK05855   7 VVSSDGVRLAVYEWGDPDRP-TVVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRssapkrtaAYTlARLAD-DFA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  85 AVlddIDALHEhiGRiPVLLFGYSMGcqlAVE-WNYRDNTRVIGLVLllgiygnifdSFlnTKIFAPMLNatyHAFPFLK 163
Cdd:PRK05855  85 AV---IDAVSP--DR-PVHLLAHDWG---SIQgWEAVTRPRAAGRIA----------SF--TSVSGPSLD---HVGFWLR 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299 164 PILKRtWRtahrlPFAIRLALGKGT------LLNPDRVNEAELRPFLDQLAELDFEYILHMSH-AIHHHTNE-------- 228
Cdd:PRK05855 141 SGLRR-PT-----PRRLARALGQLLrswyiyLFHLPVLPELLWRLGLGRAWPRLLRRVEGTPVdPIPTQTTLsdgahgvk 214

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504617299 229 ------------GQFDRIKAPCLIISGEADLFALPQHSERVHQAVAASWYFSIPAGtHNAVLEHSEEITSWIAEF 291
Cdd:PRK05855 215 lyranmirslsrPRERYTDVPVQLIVPTGDPYVRPALYDDLSRWVPRLWRREIKAG-HWLPMSHPQVLAAAVAEF 288
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 10-294 1.77e-26

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 103.54  E-value: 1.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  10 PKGYFTARDGVQLPWFEYGNlkASHTILFLNGFTCNQYNIAKVVATLGVDYRIVTFDYRGQGLAYRERyKKVSIDAVLDD 89
Cdd:COG0596    2 STPRFVTVDGVRLHYREAGP--DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPA-GGYTLDDLADD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  90 IDALHEHIGRIPVLLFGYSMGCQLAVEWNYRDNTRVIGLVLLlgiygnifdsflntkifapmlnatyhafpflkpilkrt 169
Cdd:COG0596   79 LAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLV-------------------------------------- 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299 170 wrtahrlpfairlalgkgtllnpDRVNEAELRPFLDQlaELDFEYILHMSHAIHHHTNEGQFDRIKAPCLIISGEADLFA 249
Cdd:COG0596  121 -----------------------DEVLAALAEPLRRP--GLAPEALAALLRALARTDLRERLARITVPTLVIWGEKDPIV 175

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 504617299 250 LPQHSERVHQAVAASWYFSIPAGTHNAVLEHSEEITSWIAEFLRE 294
Cdd:COG0596  176 PPALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
12-294 2.07e-13

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 68.10  E-value: 2.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  12 GYFTARDGVQLPWFEYGNLKASH-TILFLNGFTCNQYNIAKVVATL---GvdYRIVTFDYRGQGLAYRERYKKVSIDAVL 87
Cdd:COG2267    6 VTLPTRDGLRLRGRRWRPAGSPRgTVVLVHGLGEHSGRYAELAEALaaaG--YAVLAFDLRGHGRSDGPRGHVDSFDDYV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  88 DDIDALHEHIGR---IPVLLFGYSMGCQLAVEWNYRDNTRVIGLVLLlgiygnifdsflntkifAPMLNAtyhafpflKP 164
Cdd:COG2267   84 DDLRAALDALRArpgLPVVLLGHSMGGLIALLYAARYPDRVAGLVLL-----------------APAYRA--------DP 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299 165 ILKRTWRTAHRLPFAIRLAlgkgtllnpdrvneaelrpfldqlaeldfeyilhmshaihhhtnegqfdRIKAPCLIISGE 244
Cdd:COG2267  139 LLGPSARWLRALRLAEALA-------------------------------------------------RIDVPVLVLHGG 169

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 504617299 245 ADLFALPQHSERVHQAVAASW-YFSIPAGTHNAVLE-HSEEITSWIAEFLRE 294
Cdd:COG2267  170 ADRVVPPEAARRLAARLSPDVeLVLLPGARHELLNEpAREEVLAAILAWLER 221
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 35-264 3.56e-11

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 61.85  E-value: 3.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299   35 TILFLNGF--TCNQY-NIAKVVATLGvdYRIVTFDYRGQGLAYRERYKKVSIDAVLDDIDALHEHI----GRIPVLLFGY 107
Cdd:pfam12146   6 VVVLVHGLgeHSGRYaHLADALAAQG--FAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIreehPGLPLFLLGH 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  108 SMGCQLAVEWNYRDNTRVIGLVLllgiygnifdsflntkiFAPMLN-ATYHAFPFLKPILKRTWRTAHRLPFAIRLalgK 186
Cdd:pfam12146  84 SMGGLIAALYALRYPDKVDGLIL-----------------SAPALKiKPYLAPPILKLLAKLLGKLFPRLRVPNNL---L 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  187 GTLL--NPDRVNEAELRPFLDQLAELDF--EYILHMSHAihhhtnEGQFDRIKAPCLIISGEADLFALPQHSERVHQAVA 262
Cdd:pfam12146 144 PDSLsrDPEVVAAYAADPLVHGGISARTlyELLDAGERL------LRRAAAITVPLLLLHGGADRVVDPAGSREFYERAG 217


                  ..
gi 504617299  263 AS 264
Cdd:pfam12146 218 ST 219
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 35-280 1.05e-10

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 60.60  E-value: 1.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299   35 TILFLNGFTCNQYNIAKVVATLGVD-YRIVTFDYRGQGLAYRERYKK-VSIDAVLDDIDALHEHIGRIPVLLFGYSMGCQ 112
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDgFRVIALDLRGFGKSSRPKAQDdYRTDDLAEDLEYILEALGLEKVNLVGHSMGGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  113 LAVEWNYRDNTRVIGLVLLlgiygNIFDSFLNTKIFAPMLNATYHAFpFLKPILKRTwrTAHRLPF-AIRLALGKGTLLN 191
Cdd:pfam00561  82 IALAYAAKYPDRVKALVLL-----GALDPPHELDEADRFILALFPGF-FDGFVADFA--PNPLGRLvAKLLALLLLRLRL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  192 PDRVNEAELRP---FLDQLAELDFEYILHMSHAIHHHTNEgQFDRIKAPCLIISGEADLFALPQHSERVHQAVAASWYFS 268
Cdd:pfam00561 154 LKALPLLNKRFpsgDYALAKSLVTGALLFIETWSTELRAK-FLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVV 232

                         250
                  ....*....|..
gi 504617299  269 IPAGTHNAVLEH 280
Cdd:pfam00561 233 IPDAGHFAFLEG 244
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
14-293 1.41e-09

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 57.33  E-value: 1.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  14 FTARDGVQLP-WFEYGNLKASH-TILFLNGFTCNQYN----IAKVVATLGvdYRIVTFDYRGQGLAYRERYKKVSIDaVL 87
Cdd:COG1506    2 FKSADGTTLPgWLYLPADGKKYpVVVYVHGGPGSRDDsflpLAQALASRG--YAVLAPDYRGYGESAGDWGGDEVDD-VL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  88 DDIDALHEH--IGRIPVLLFGYSMGCQLAvewnyrdntrviglVLLLGIYGNIFDSFLntkIFAPMLNatyhafpflkpi 165
Cdd:COG1506   79 AAIDYLAARpyVDPDRIGIYGHSYGGYMA--------------LLAAARHPDRFKAAV---ALAGVSD------------ 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299 166 lkrtWRTAHRLPFAIRLALGKGTLLNPDRVNEAELRPFLdqlaeldfeyilhmshaihhhtnegqfDRIKAPCLIISGEA 245
Cdd:COG1506  130 ----LRSYYGTTREYTERLMGGPWEDPEAYAARSPLAYA---------------------------DKLKTPLLLIHGEA 178

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 504617299 246 DLFALPQHSERVHQAVAA----SWYFSIPAGTHNAVLEHS----EEITSWIAEFLR 293
Cdd:COG1506  179 DDRVPPEQAERLYEALKKagkpVELLVYPGEGHGFSGAGApdylERILDFLDRHLK 234
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 36-284 4.25e-08

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 52.48  E-value: 4.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299   36 ILFLNGFTcnqYNIAKVVATLGVDYRIVTFDYRGQGLAYRERYkkvSIDAVLDDIDALHEHIGRIPVLLFGYSMGCQLAv 115
Cdd:pfam12697   1 VVLVHGAG---LSAAPLAALLAAGVAVLAPDLPGHGSSSPPPL---DLADLADLAALLDELGAARPVVLVGHSLGGAVA- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  116 ewnyrdnTRVIGLVLLLGIYgnifdsfLNTKIFAPMLNATYHAF--PFLKPILKRTWRTAHRLPFAirlalgkgtlLNPD 193
Cdd:pfam12697  74 -------LAAAAAALVVGVL-------VAPLAAPPGLLAALLALlaRLGAALAAPAWLAAESLARG----------FLDD 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  194 RVNEAELRPFLDQLAELDFEYILHMSHAihhhtnegqFDRIKAPCLIISGEADlfALPQHSERVHQAVAASWYFSIPAGT 273
Cdd:pfam12697 130 LPADAEWAAALARLAALLAALALLPLAA---------WRDLPVPVLVLAEEDR--LVPELAQRLLAALAGARLVVLPGAG 198

                         250
                  ....*....|.
gi 504617299  274 HnAVLEHSEEI 284
Cdd:pfam12697 199 H-LPLDDPEEV 208
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
23-294 1.11e-07

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 51.87  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  23 PWFEYGNLKAshtILFLNGFTCNQY---NIAKVVATLGvdYRIVTFDYRGQGLAYRErYKKVS----IDAVLDDIDALHE 95
Cdd:COG1647    8 PFFLEGGRKG---VLLLHGFTGSPAemrPLAEALAKAG--YTVYAPRLPGHGTSPED-LLKTTwedwLEDVEEAYEILKA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  96 HIGRipVLLFGYSMGCQLAVeWNYRDNTRVIGLVLLlgiygnifdsflntkifAPMLNATYHAFPFLkPILKRtwrtahr 175
Cdd:COG1647   82 GYDK--VIVIGLSMGGLLAL-LLAARYPDVAGLVLL-----------------SPALKIDDPSAPLL-PLLKY------- 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299 176 lpFAIRLALGKGTLLNPDRVNEAELRPFLDQLAELdFEYILHMSHaihhhtnegQFDRIKAPCLIISGEADLFALPQHSE 255
Cdd:COG1647  134 --LARSLRGIGSDIEDPEVAEYAYDRTPLRALAEL-QRLIREVRR---------DLPKITAPTLIIQSRKDEVVPPESAR 201

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 504617299 256 RVHQAVAASW--YFSIPAGTHNAVLEHS-EEITSWIAEFLRE 294
Cdd:COG1647  202 YIYERLGSPDkeLVWLEDSGHVITLDKDrEEVAEEILDFLER 243
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 2-294 3.08e-05

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 44.52  E-value: 3.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299   2 YSFERYPVPKGYFTARDGVQL--PWFEYGNLKASH-TILFLNGFTCN--QY-NIAKVVATLGVDyrIVTFDYRGQGLA-- 73
Cdd:COG1073    3 PPSDKVNKEDVTFKSRDGIKLagDLYLPAGASKKYpAVVVAHGNGGVkeQRaLYAQRLAELGFN--VLAFDYRGYGESeg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  74 -YRErykkvSIDAVLDDIDALHEHIGRIP------VLLFGYSMGC----QLAVEwnyrdNTRVIGLVLLLGiygniFDSF 142
Cdd:COG1073   81 ePRE-----EGSPERRDARAAVDYLRTLPgvdperIGLLGISLGGgyalNAAAT-----DPRVKAVILDSP-----FTSL 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299 143 --LNTKIFAPMLNATYHAFPFLKPIlkrtwrtahrlpfairlalgkgtllnpdrvneaELRPFLDQLAELdFEYIlhmsh 220
Cdd:COG1073  146 edLAAQRAKEARGAYLPGVPYLPNV---------------------------------RLASLLNDEFDP-LAKI----- 186

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 504617299 221 aihhhtnegqfDRIKAPCLIISGEADLFALPQHSERVHQAVAASW-YFSIPAGTHN-AVLEHSEEITSWIAEFLRE 294
Cdd:COG1073  187 -----------EKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKeLLIVPGAGHVdLYDRPEEEYFDKLAEFFKK 251
PRK05855 PRK05855
SDR family oxidoreductase;
14-291 1.39e-04

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 43.05  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  14 FTARDGVQLPWFEYGNLKAShTILFLNGFTCNQYNIAKVVATLGVDYRIVTFDYRGQGL--------AYR-ERYKKvSID 84
Cdd:PRK05855   7 VVSSDGVRLAVYEWGDPDRP-TVVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRssapkrtaAYTlARLAD-DFA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  85 AVlddIDALHEhiGRiPVLLFGYSMGcqlAVE-WNYRDNTRVIGLVLllgiygnifdSFlnTKIFAPMLNatyHAFPFLK 163
Cdd:PRK05855  85 AV---IDAVSP--DR-PVHLLAHDWG---SIQgWEAVTRPRAAGRIA----------SF--TSVSGPSLD---HVGFWLR 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299 164 PILKRtWRtahrlPFAIRLALGKGT------LLNPDRVNEAELRPFLDQLAELDFEYILHMSH-AIHHHTNE-------- 228
Cdd:PRK05855 141 SGLRR-PT-----PRRLARALGQLLrswyiyLFHLPVLPELLWRLGLGRAWPRLLRRVEGTPVdPIPTQTTLsdgahgvk 214

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 504617299 229 ------------GQFDRIKAPCLIISGEADLFALPQHSERVHQAVAASWYFSIPAGtHNAVLEHSEEITSWIAEF 291
Cdd:PRK05855 215 lyranmirslsrPRERYTDVPVQLIVPTGDPYVRPALYDDLSRWVPRLWRREIKAG-HWLPMSHPQVLAAAVAEF 288
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 24-79 2.35e-04

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 42.18  E-value: 2.35e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 504617299  24 WF--EYGNlKASHTILFLNGFTCNQYNIAKVVATLGVDYRIVTFDYRGQGLAYRERYK 79
Cdd:PLN03084 117 WFcvESGS-NNNPPVLLIHGFPSQAYSYRKVLPVLSKNYHAIAFDWLGFGFSDKPQPG 173
GrsT COG3208
Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and ...
 82-116 9.92e-04

Surfactin synthase thioesterase subunit [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442441 [Multi-domain]  Cd Length: 237  Bit Score: 39.84  E-value: 9.92e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 504617299  82 SIDAVLDDI-DALHEHIGRiPVLLFGYSMGCQLAVE 116
Cdd:COG3208   54 SLEELADDLaEELAPLLDR-PFALFGHSMGALLAFE 88
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
14-114 2.73e-03

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 38.71  E-value: 2.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504617299  14 FTARDGVQLPWFEYGNLKASHTILFLN---GFTCNQY-NIAKVVATLGvdYRIVTFDYRGQGLAYRERYKKVS------- 82
Cdd:COG4757   12 ITAADGYPLAARLFPPAGPPRAVVLINpatGVPQRFYrPFARYLAERG--FAVLTYDYRGIGLSRPGSLRGFDagyrdwg 89

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 504617299  83 ---IDAVLddiDALHEHIGRIPVLLFGYSMGCQLA 114
Cdd:COG4757   90 eldLPAVL---DALRARFPGLPLLLVGHSLGGQLL 121
Thioesterase pfam00975
Thioesterase domain; Peptide synthetases are involved in the non-ribosomal synthesis of ...
 82-116 9.99e-03

Thioesterase domain; Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates. There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.


Pssm-ID: 395776 [Multi-domain]  Cd Length: 223  Bit Score: 36.60  E-value: 9.99e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 504617299   82 SIDAVLDD-IDALHEHIGRIPVLLFGYSMGCQLAVE 116
Cdd:pfam00975  46 SIEALADEyAEALRQIQPEGPYALFGHSMGGMLAFE 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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