Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1880321587 224 IDECRSQ-PCLHGATCQDAPGGYSCDCAPGFLGEHCE 259
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20
                  ....*....|....*....|....*....
gi 1880321587 308 PCHNDATCEDTVDSYICHCRPGYTGALCE 336
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1880321587 262 VNECESQ-PCLHGGLCVDGRNSYHCDCTgSGFTGMHCE 298
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|.
gi 1880321587 676 ESQPCQNRGRCINLWQGYQCECDRPYTGSNC 706
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321587 484 TLSFGSNGFLWVTSGSHTGigPECNISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVwNQLKVLLSISHNT 561
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPR--TRLSISFSFRTTSPNGLLLYAGSQNGGdfLALELEDGRLVLRYDL-GSGSLVLSSKTPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321587 562 SDGEWHFVEVTI-AETLTLALVGGSCKEKCTTKSSVPVENHQSIcalqdsFLGGLPMGTANNSVsvlniynvPSTPSFVG 640
Cdd:cd00110    78 NDGQWHSVSVERnGRSVTLSVDGERVVESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGFVG 143

                  ....*...
gi 1880321587 641 CLQDIRFD 648
Cdd:cd00110   144 CIRDLKVN 151

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1880321587 224 IDECRSQ-PCLHGATCQDAPGGYSCDCAPGFLGEHCE 259
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1880321587  223 EIDECRS-QPCLHGATCQDAPGGYSCDCAPGF-LGEHCE 259
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20
                  ....*....|....*....|....*....
gi 1880321587 308 PCHNDATCEDTVDSYICHCRPGYTGALCE 336
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1880321587 262 VNECESQ-PCLHGGLCVDGRNSYHCDCTgSGFTGMHCE 298
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20
                  ....*....|....*....|....*....
gi 1880321587 396 DVDECLL-HPCLNGGTCENLPGNYACHCP 423
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|.
gi 1880321587 676 ESQPCQNRGRCINLWQGYQCECDRPYTGSNC 706
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                          10        20        30
                  ....*....|....*....|....*....|.
gi 1880321587 151 CASSPCHNGAMCQDGINGYSCFCVPGYQGRH 181
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                          10        20        30
                  ....*....|....*....|....*....|.
gi 1880321587 675 CESQPCQNRGRCINLWQGYQCECDRPYTGSN 705
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                          10        20        30
                  ....*....|....*....|....*....|.
gi 1880321587 113 CGGNLCQHGGTCRKDPEHPVCICPPGYAGRF 143
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321587 484 TLSFGSNGFLWVTSGSHTGigPECNISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVwNQLKVLLSISHNT 561
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPR--TRLSISFSFRTTSPNGLLLYAGSQNGGdfLALELEDGRLVLRYDL-GSGSLVLSSKTPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321587 562 SDGEWHFVEVTI-AETLTLALVGGSCKEKCTTKSSVPVENHQSIcalqdsFLGGLPMGTANNSVsvlniynvPSTPSFVG 640
Cdd:cd00110    78 NDGQWHSVSVERnGRSVTLSVDGERVVESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGFVG 143

                  ....*...
gi 1880321587 641 CLQDIRFD 648
Cdd:cd00110   144 CIRDLKVN 151

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1880321587 224 IDECRSQ-PCLHGATCQDAPGGYSCDCAPGFLGEHCE 259
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Laminin G domain;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321587 513 FHTVQPNALLLIRG--NKDVSMKLELLNGCVHLSIEVWNQlKVLLSISHNTSDGEWHFVEVTIAET-LTLALVGGSckek 589
Cdd:pfam00054   1 FRTTEPSGLLLYNGtqTERDFLALELRDGRLEVSYDLGSG-AAVVRSGDKLNDGKWHSVELERNGRsGTLSVDGEA---- 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1880321587 590 cTTKSSVPVENHQSICALQDSFLGGLPmgtannSVSVLNiYNVPSTPSFVGCLQDIRFD 648
Cdd:pfam00054  76 -RPTGESPLGATTDLDVDGPLYVGGLP------SLGVKK-RRLAISPSFDGCIRDVIVN 126

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1880321587  147 DHNECAS-SPCHNGAMCQDGINGYSCFCVPGYQ-GRHCD 183
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1880321587 186 VDECVS-DPCKNEAVCLNEIGRYTCVCPQEFSGVNCE 221
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1880321587  396 DVDECLL-HPCLNGGTCENLPGNYACHCPfddtsRTFYGGENC 437
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|
gi 1880321587  308 PCHNDATCEDTVDSYICHCRPGYT-GALCE 336
Cdd:smart00179  10 PCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                          10        20        30
                  ....*....|....*....|....*....|.
gi 1880321587 227 CRSQPCLHGATCQDAPGGYSCDCAPGFLGEH 257
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1880321587  262 VNECES-QPCLHGGLCVDGRNSYHCDCtGSGFT-GMHCE 298
Cdd:smart00179   2 IDECASgNPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1880321587  185 EVDECVS-DPCKNEAVCLNEIGRYTCVCPQEFS-GVNCE 221
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                          10        20        30
                  ....*....|....*....|....*....|.
gi 1880321587 113 CGGNLCQHGGTCRKDPEHPVCICPPGYAGRF 143
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 1880321587 228 RSQPCLHGATCQDAPGGYSCDCAPGFLGE-HCE 259
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36