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Conserved domains on  [gi|1875036280|gb|QLJ11134|]
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toll-like receptor 3 [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
755-900 6.97e-23

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 95.47  E-value: 6.97e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  755 EYAAYIIHAYKDrdWVWKHFSPM-EEEDHTLRFCLEERDFEAGVLELEAIVNSIRRSRKIIFVVTQNLLKDPLCKsFKVH 833
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHlLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCL-DELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1875036280  834 HAVQQAIEQNLDSIILIFLEEIPDYKLNHALCLRRGMFKShcILNWPVQKERvnAFHHKLKVALGSR 900
Cdd:smart00255  78 AALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN--YLKWPEDEKE--QFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-406 3.73e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 3.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  52 TNITVLNLTHNQlrrlppaNFTRYSQLTILDGGFNSISKLEPELCQsLPWLEILNLQHNEISQLsDKTFIFCMNLTELHL 131
Cdd:COG4886    96 TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 132 MSNSIQKIKnDPFKNLKNLIKLDLShnglsstklgtqlqlenlqelllsNNKISSLTPEefdFLGNSSLKRLELSSNQIK 211
Cdd:COG4886   167 SNNQLTDLP-EELGNLTNLKELDLS------------------------NNQITDLPEP---LGNLTNLEELDLSGNQLT 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 212 EFsPGCFHALGELSGLSLNNAKLS--PSLTeklclelSNTSIENLSLSSNQLDTISHTtfdgLKQTNLTTLDLSRNSLRV 289
Cdd:COG4886   219 DL-PEPLANLTNLETLDLSNNQLTdlPELG-------NLTNLEELDLSNNQLTDLPPL----ANLTNLKTLDLSNNQLTD 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 290 MGNDSFAWLPHLEYLSLEYNNIEHLSSRSFYGLSNLRRLDLRRSFTRQS*SLTSLPKIDDFSFQWLKCLEYLNMDDNNFP 369
Cdd:COG4886   287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1875036280 370 GIKRNTFTGLVRLKFLSLSNSFSSLRTLTNETFLSLA 406
Cdd:COG4886   367 LTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLL 403
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
303-667 4.54e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 4.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 303 YLSLEYNNIEHLSSRSFYGLSNLRRLDLRRSFTRQS*SLTSLPKIDDFSFQWLKCLEYLNMDDNNFPGIKRNTFTGLVRL 382
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 383 KFLSLSNSFSSLRTLTNETFLSLAGCPLLLLNL-------TKNKISKIqSGAFSWLGHLEVLDLGLNEIGQelTGQEWRG 455
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTnlesldlSGNQLTDL-PEELANLTNLKELDLSNNQLTD--LPEPLGN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 456 LDNIVEIYLSYNKYLELTtNSFTSVPSLQRLMLRRVALKNVdcsPSPFRPLPNLVILDLSNNNIANINDELlKGLEKLEI 535
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLET 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 536 LDLQHNNLARLwkhanpggpvQFLKGLFHLHILNLGSNGFDEIPVEAfkDLRELKSIDLGMNNLNILPQSVFDNQVSLKS 615
Cdd:COG4886   233 LDLSNNQLTDL----------PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1875036280 616 LSLQKNLITSVQKTVFGPAFRNLSYLDMRFNPFDCTCESIAWFVNWINITHT 667
Cdd:COG4886   301 LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352
Tlr3_TMD pfam17968
Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR ...
 699-731 6.65e-06

Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. This entry represents the Toll-like receptor 3 trans-membrane domain which has been shown to form dimers and trimers with different surfaces for helix-helix interaction.


:

Pssm-ID: 465595  Cd Length: 33  Bit Score: 43.45  E-value: 6.65e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1875036280 699 DSAPFELLFMININILLIFIFIVLLIHFEGWRI 731
Cdd:pfam17968   1 DSAPFKLLFVISSTAVLLFIFIVLLIHFQGWRI 33
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
646-698 3.08e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 3.08e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1875036280  646 NPFDCTCEsIAWFVNWINitHTNISELSNHYLCNTPPQYHGyPV--MLFDVSPCK 698
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQ--ANEHLQDPVDLRCASPSSLRG-PLleLLHSEFKCP 51
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
755-900 6.97e-23

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 95.47  E-value: 6.97e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  755 EYAAYIIHAYKDrdWVWKHFSPM-EEEDHTLRFCLEERDFEAGVLELEAIVNSIRRSRKIIFVVTQNLLKDPLCKsFKVH 833
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHlLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCL-DELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1875036280  834 HAVQQAIEQNLDSIILIFLEEIPDYKLNHALCLRRGMFKShcILNWPVQKERvnAFHHKLKVALGSR 900
Cdd:smart00255  78 AALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN--YLKWPEDEKE--QFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-406 3.73e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 3.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  52 TNITVLNLTHNQlrrlppaNFTRYSQLTILDGGFNSISKLEPELCQsLPWLEILNLQHNEISQLsDKTFIFCMNLTELHL 131
Cdd:COG4886    96 TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 132 MSNSIQKIKnDPFKNLKNLIKLDLShnglsstklgtqlqlenlqelllsNNKISSLTPEefdFLGNSSLKRLELSSNQIK 211
Cdd:COG4886   167 SNNQLTDLP-EELGNLTNLKELDLS------------------------NNQITDLPEP---LGNLTNLEELDLSGNQLT 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 212 EFsPGCFHALGELSGLSLNNAKLS--PSLTeklclelSNTSIENLSLSSNQLDTISHTtfdgLKQTNLTTLDLSRNSLRV 289
Cdd:COG4886   219 DL-PEPLANLTNLETLDLSNNQLTdlPELG-------NLTNLEELDLSNNQLTDLPPL----ANLTNLKTLDLSNNQLTD 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 290 MGNDSFAWLPHLEYLSLEYNNIEHLSSRSFYGLSNLRRLDLRRSFTRQS*SLTSLPKIDDFSFQWLKCLEYLNMDDNNFP 369
Cdd:COG4886   287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1875036280 370 GIKRNTFTGLVRLKFLSLSNSFSSLRTLTNETFLSLA 406
Cdd:COG4886   367 LTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLL 403
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
303-667 4.54e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 4.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 303 YLSLEYNNIEHLSSRSFYGLSNLRRLDLRRSFTRQS*SLTSLPKIDDFSFQWLKCLEYLNMDDNNFPGIKRNTFTGLVRL 382
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 383 KFLSLSNSFSSLRTLTNETFLSLAGCPLLLLNL-------TKNKISKIqSGAFSWLGHLEVLDLGLNEIGQelTGQEWRG 455
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTnlesldlSGNQLTDL-PEELANLTNLKELDLSNNQLTD--LPEPLGN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 456 LDNIVEIYLSYNKYLELTtNSFTSVPSLQRLMLRRVALKNVdcsPSPFRPLPNLVILDLSNNNIANINDELlKGLEKLEI 535
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLET 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 536 LDLQHNNLARLwkhanpggpvQFLKGLFHLHILNLGSNGFDEIPVEAfkDLRELKSIDLGMNNLNILPQSVFDNQVSLKS 615
Cdd:COG4886   233 LDLSNNQLTDL----------PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1875036280 616 LSLQKNLITSVQKTVFGPAFRNLSYLDMRFNPFDCTCESIAWFVNWINITHT 667
Cdd:COG4886   301 LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 73-646 3.35e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.65  E-value: 3.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  73 TRYSQLTILD-GGFNSISKLEPELCQsLPWLEILNLQHNEIS-QLSDKTFIFCMNLTELHLMSNSIQKikNDPFKNLKNL 150
Cdd:PLN00113   66 NNSSRVVSIDlSGKNISGKISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG--SIPRGSIPNL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 151 IKLDLShnglsstklgtqlqlenlqelllsNNKISSLTPEEFDFLgnSSLKRLELSSNQIKEFSPGCFHALGELSGLSLn 230
Cdd:PLN00113  143 ETLDLS------------------------NNMLSGEIPNDIGSF--SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTL- 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 231 nakLSPSLTEKLCLELSNT-SIENLSLSSNQLDTISHTTFDGLkqTNLTTLDLSRNSLRVMGNDSFAWLPHLEYLSLEYN 309
Cdd:PLN00113  196 ---ASNQLVGQIPRELGQMkSLKWIYLGYNNLSGEIPYEIGGL--TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 310 NIEHLSSRSFYGLSNLRRLDLRRSFTRQs*sltslpKIDDFSFQwLKCLEYLNMDDNNFPGIKRNTFTGLVRLKflslsn 389
Cdd:PLN00113  271 KLSGPIPPSIFSLQKLISLDLSDNSLSG--------EIPELVIQ-LQNLEILHLFSNNFTGKIPVALTSLPRLQ------ 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 390 sfsslrtltnetFLSLagcpllllnlTKNKISKIQSGAFSWLGHLEVLDLGLNEigqeLTGQEWRGL---DNIVEIYLSY 466
Cdd:PLN00113  336 ------------VLQL----------WSNKFSGEIPKNLGKHNNLTVLDLSTNN----LTGEIPEGLcssGNLFKLILFS 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 467 NKYLELTTNSFTSVPSLQRLMLRRVALKNVdcSPSPFRPLPNLVILDLSNNNI-ANINDELLKgLEKLEILDLQHNNLAr 545
Cdd:PLN00113  390 NSLEGEIPKSLGACRSLRRVRLQDNSFSGE--LPSEFTKLPLVYFLDISNNNLqGRINSRKWD-MPSLQMLSLARNKFF- 465

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 546 lwkhanpGGPVQFLkGLFHLHILNLGSNGFDEIPVEAFKDLRELKSIDLGMNNLNILPQSVFDNQVSLKSLSLQKNLITS 625
Cdd:PLN00113  466 -------GGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSG 537

                         570       580
                  ....*....|....*....|.
gi 1875036280 626 VQKTVFGpAFRNLSYLDMRFN 646
Cdd:PLN00113  538 QIPASFS-EMPVLSQLDLSQN 557
LRR_8 pfam13855
Leucine rich repeat;
275-332 1.19e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.19e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1875036280 275 TNLTTLDLSRNSLRVMGNDSFAWLPHLEYLSLEYNNIEHLSSRSFYGLSNLRRLDLRR 332
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 418-541 6.17e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 6.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 418 NKISKIQSgaFSWLGHLEVLDLGLNEIgQELTGQEwrGLDNIVEIYLSYNK-----YLELTTNSFTSV-PSLQRLMLRRv 491
Cdd:cd21340    56 NQIEKIEN--LENLVNLKKLYLGGNRI-SVVEGLE--NLTNLEELHIENQRlppgeKLTFDPRSLAALsNSLRVLNISG- 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1875036280 492 alKNVDcSPSPFRPLPNLVILDLSNNNIANIND--ELLKGLEKLEILDLQHN 541
Cdd:cd21340   130 --NNID-SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
481-543 1.09e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 1.09e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1875036280 481 PSLQRLMLRRVALKNVDcsPSPFRPLPNLVILDLSNNNIANINDELLKGLEKLEILDLQHNNL 543
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-208 5.70e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.41  E-value: 5.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  38 CSHLKLTQIPD-DLPTNITVLNLTHNQLRRLPpaNFTRYSQLTILDGGFNSISKLEPElcQSLPWLEILNLQHNEISQLS 116
Cdd:cd21340     9 LNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRISVVE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 117 --DKtfifCMNLTELHLMSNSI---QKIKNDPFKNL---KNLIKLDLSHNGLSStkLGTQLQLENLQELLLSNNKISSLT 188
Cdd:cd21340    85 glEN----LTNLEELHIENQRLppgEKLTFDPRSLAalsNSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLE 158

                         170       180
                  ....*....|....*....|
gi 1875036280 189 PEEFDFLGNSSLKRLELSSN 208
Cdd:cd21340   159 ELLDLLSSWPSLRELDLTGN 178
Tlr3_TMD pfam17968
Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR ...
 699-731 6.65e-06

Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. This entry represents the Toll-like receptor 3 trans-membrane domain which has been shown to form dimers and trimers with different surfaces for helix-helix interaction.


Pssm-ID: 465595  Cd Length: 33  Bit Score: 43.45  E-value: 6.65e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1875036280 699 DSAPFELLFMININILLIFIFIVLLIHFEGWRI 731
Cdd:pfam17968   1 DSAPFKLLFVISSTAVLLFIFIVLLIHFQGWRI 33
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 787-880 9.66e-06

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 46.59  E-value: 9.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 787 CLEERDFEAGVLELEAIVNSIRRSRKIIFVVTQNLLKDPLCKsFKVHHAVQQAIEQNLdSIILIFLEEIPDYKLNHALCL 866
Cdd:pfam01582  32 FIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCL-DELVKILECALDLGQ-KVIPIFYEVDPSDVRKQTGSF 109

                          90       100
                  ....*....|....*....|.
gi 1875036280 867 RRGmFKSHC-------ILNWP 880
Cdd:pfam01582 110 GKA-FKKHKkvlteekVLKWR 129
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
468-692 2.49e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 2.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 468 KYLELTTNSFTSVPSLQRLMLRRVALKNVDCSPSPFRpLPN-LVILDLSNNNIANINDELLKGLEKLEILDlqhNNLARL 546
Cdd:PRK15370  223 KTLYANSNQLTSIPATLPDTIQEMELSINRITELPER-LPSaLQSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTL 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 547 WKHAnPGGPVQ---------FLKGLF--HLHILNLGSNGFDEIPvEAFKDlrELKSIDLGMNNLNILPQSVfdnQVSLKS 615
Cdd:PRK15370  299 PAHL-PSGITHlnvqsnsltALPETLppGLKTLEAGENALTSLP-ASLPP--ELQVLDVSKNQITVLPETL---PPTITT 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 616 LSLQKNLITSVQKTVfgPAfrNLSYLDMRFNPFDCTCESIAWFVN------WINITHTNISE--LSNHYLCNTPPQYHGy 687
Cdd:PRK15370  372 LDVSRNALTNLPENL--PA--ALQIMQASRNNLVRLPESLPHFRGegpqptRIIVEYNPFSErtIQNMQRLMSSVGYQG- 446


                  ....*
gi 1875036280 688 PVMLF 692
Cdd:PRK15370  447 PRVLF 451
LRRCT smart00082
Leucine rich repeat C-terminal domain;
646-698 3.08e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 3.08e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1875036280  646 NPFDCTCEsIAWFVNWINitHTNISELSNHYLCNTPPQYHGyPV--MLFDVSPCK 698
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQ--ANEHLQDPVDLRCASPSSLRG-PLleLLHSEFKCP 51
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 618-690 9.98e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.15  E-value: 9.98e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1875036280  618 LQKNLITSVQKTVFGPAFrNLSYLDMRFNPFDCTCeSIAWFVNWINITHTNISElSNHYLCNTPPQYHGYPVM 690
Cdd:TIGR00864    2 ISNNKISTIEEGICANLC-NLSEIDLSGNPFECDC-GLARLPRWAEEKGVKVRQ-PEAALCAGPGALAGQPLL 71
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
755-900 6.97e-23

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 95.47  E-value: 6.97e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  755 EYAAYIIHAYKDrdWVWKHFSPM-EEEDHTLRFCLEERDFEAGVLELEAIVNSIRRSRKIIFVVTQNLLKDPLCKsFKVH 833
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHlLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCL-DELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1875036280  834 HAVQQAIEQNLDSIILIFLEEIPDYKLNHALCLRRGMFKShcILNWPVQKERvnAFHHKLKVALGSR 900
Cdd:smart00255  78 AALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN--YLKWPEDEKE--QFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-406 3.73e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 3.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  52 TNITVLNLTHNQlrrlppaNFTRYSQLTILDGGFNSISKLEPELCQsLPWLEILNLQHNEISQLsDKTFIFCMNLTELHL 131
Cdd:COG4886    96 TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 132 MSNSIQKIKnDPFKNLKNLIKLDLShnglsstklgtqlqlenlqelllsNNKISSLTPEefdFLGNSSLKRLELSSNQIK 211
Cdd:COG4886   167 SNNQLTDLP-EELGNLTNLKELDLS------------------------NNQITDLPEP---LGNLTNLEELDLSGNQLT 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 212 EFsPGCFHALGELSGLSLNNAKLS--PSLTeklclelSNTSIENLSLSSNQLDTISHTtfdgLKQTNLTTLDLSRNSLRV 289
Cdd:COG4886   219 DL-PEPLANLTNLETLDLSNNQLTdlPELG-------NLTNLEELDLSNNQLTDLPPL----ANLTNLKTLDLSNNQLTD 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 290 MGNDSFAWLPHLEYLSLEYNNIEHLSSRSFYGLSNLRRLDLRRSFTRQS*SLTSLPKIDDFSFQWLKCLEYLNMDDNNFP 369
Cdd:COG4886   287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1875036280 370 GIKRNTFTGLVRLKFLSLSNSFSSLRTLTNETFLSLA 406
Cdd:COG4886   367 LTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLL 403
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-287 4.31e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 4.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  37 DCSHLKLTQIPDDLP--TNITVLNLTHNQLRRLPPAnFTRYSQLTILDGGFNSISKLEPELCQsLPWLEILNLQHNEISQ 114
Cdd:COG4886   142 DLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTD 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 115 LSDkTFIFCMNLTELHLMSNSIQKIKNdpFKNLKNLIKLDLSHNGLSStkLGTQLQLENLQELLLSNNKISSLTPEEFDF 194
Cdd:COG4886   220 LPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 195 LGNSSLKRLELSSNQIKEFSPGcFHALGELSGLSLNNAKLSPSLTEKLCLELSNTSIENLSLSSNQLDTISHTTFDGLKQ 274
Cdd:COG4886   295 LLGLNSLLLLLLLLNLLELLIL-LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                         250
                  ....*....|...
gi 1875036280 275 TNLTTLDLSRNSL 287
Cdd:COG4886   374 LLEATLLTLALLL 386
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-479 1.39e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 1.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  37 DCSHLKLTQIPDDLPTNITVLNLTHNQLRRLPPANFTRYSQLTILDGGFNSISKLEPELCQSLPWLEILNLQHNEISQLS 116
Cdd:COG4886    14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 117 DKTfifcmNLTELHLMSNsiqkiknDPFKNLKNLIKLDLSHNGLSS--------TKLgtqlqlenlQELLLSNNKISSLt 188
Cdd:COG4886    94 DLT-----NLTELDLSGN-------EELSNLTNLESLDLSGNQLTDlpeelanlTNL---------KELDLSNNQLTDL- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 189 PEEFDFLgnSSLKRLELSSNQIKEFSPgcfhalgELSGLslnnaklspslteklclelsnTSIENLSLSSNQLDTISHtT 268
Cdd:COG4886   152 PEPLGNL--TNLKSLDLSNNQLTDLPE-------ELGNL---------------------TNLKELDLSNNQITDLPE-P 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 269 FDGLkqTNLTTLDLSRNSLRVMGnDSFAWLPHLEYLSLEYNNIEHLSsrSFYGLSNLRRLDLRRSftrqs*SLTSLPKID 348
Cdd:COG4886   201 LGNL--TNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN------QLTDLPPLA 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 349 DfsfqwLKCLEYLNMDDNNFPGIKRNTFTGLVRLKFLSLSNSFSSLRtLTNETFLSLAGCPLLLLNLTKNKISKIQSGAF 428
Cdd:COG4886   270 N-----LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL-ELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1875036280 429 SWLGHLEVLDLGLNEIGQELTGQEWRGLDNIVEIYLSYNKYLELTTNSFTS 479
Cdd:COG4886   344 LSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
303-667 4.54e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 4.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 303 YLSLEYNNIEHLSSRSFYGLSNLRRLDLRRSFTRQS*SLTSLPKIDDFSFQWLKCLEYLNMDDNNFPGIKRNTFTGLVRL 382
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 383 KFLSLSNSFSSLRTLTNETFLSLAGCPLLLLNL-------TKNKISKIqSGAFSWLGHLEVLDLGLNEIGQelTGQEWRG 455
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTnlesldlSGNQLTDL-PEELANLTNLKELDLSNNQLTD--LPEPLGN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 456 LDNIVEIYLSYNKYLELTtNSFTSVPSLQRLMLRRVALKNVdcsPSPFRPLPNLVILDLSNNNIANINDELlKGLEKLEI 535
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLET 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 536 LDLQHNNLARLwkhanpggpvQFLKGLFHLHILNLGSNGFDEIPVEAfkDLRELKSIDLGMNNLNILPQSVFDNQVSLKS 615
Cdd:COG4886   233 LDLSNNQLTDL----------PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1875036280 616 LSLQKNLITSVQKTVFGPAFRNLSYLDMRFNPFDCTCESIAWFVNWINITHT 667
Cdd:COG4886   301 LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 73-646 3.35e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.65  E-value: 3.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  73 TRYSQLTILD-GGFNSISKLEPELCQsLPWLEILNLQHNEIS-QLSDKTFIFCMNLTELHLMSNSIQKikNDPFKNLKNL 150
Cdd:PLN00113   66 NNSSRVVSIDlSGKNISGKISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTG--SIPRGSIPNL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 151 IKLDLShnglsstklgtqlqlenlqelllsNNKISSLTPEEFDFLgnSSLKRLELSSNQIKEFSPGCFHALGELSGLSLn 230
Cdd:PLN00113  143 ETLDLS------------------------NNMLSGEIPNDIGSF--SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTL- 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 231 nakLSPSLTEKLCLELSNT-SIENLSLSSNQLDTISHTTFDGLkqTNLTTLDLSRNSLRVMGNDSFAWLPHLEYLSLEYN 309
Cdd:PLN00113  196 ---ASNQLVGQIPRELGQMkSLKWIYLGYNNLSGEIPYEIGGL--TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 310 NIEHLSSRSFYGLSNLRRLDLRRSFTRQs*sltslpKIDDFSFQwLKCLEYLNMDDNNFPGIKRNTFTGLVRLKflslsn 389
Cdd:PLN00113  271 KLSGPIPPSIFSLQKLISLDLSDNSLSG--------EIPELVIQ-LQNLEILHLFSNNFTGKIPVALTSLPRLQ------ 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 390 sfsslrtltnetFLSLagcpllllnlTKNKISKIQSGAFSWLGHLEVLDLGLNEigqeLTGQEWRGL---DNIVEIYLSY 466
Cdd:PLN00113  336 ------------VLQL----------WSNKFSGEIPKNLGKHNNLTVLDLSTNN----LTGEIPEGLcssGNLFKLILFS 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 467 NKYLELTTNSFTSVPSLQRLMLRRVALKNVdcSPSPFRPLPNLVILDLSNNNI-ANINDELLKgLEKLEILDLQHNNLAr 545
Cdd:PLN00113  390 NSLEGEIPKSLGACRSLRRVRLQDNSFSGE--LPSEFTKLPLVYFLDISNNNLqGRINSRKWD-MPSLQMLSLARNKFF- 465

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 546 lwkhanpGGPVQFLkGLFHLHILNLGSNGFDEIPVEAFKDLRELKSIDLGMNNLNILPQSVFDNQVSLKSLSLQKNLITS 625
Cdd:PLN00113  466 -------GGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSG 537

                         570       580
                  ....*....|....*....|.
gi 1875036280 626 VQKTVFGpAFRNLSYLDMRFN 646
Cdd:PLN00113  538 QIPASFS-EMPVLSQLDLSQN 557
LRR_8 pfam13855
Leucine rich repeat;
275-332 1.19e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.19e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1875036280 275 TNLTTLDLSRNSLRVMGNDSFAWLPHLEYLSLEYNNIEHLSSRSFYGLSNLRRLDLRR 332
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
181-646 6.57e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 6.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 181 NNKISSLTPEEFDFLGNSSLKRLELSSNQIKEFSPGCFHALGELSGLSLNNAKLSPSLTEKLCLELSNTSIENLSLSSNQ 260
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 261 LDTISHTTFDGLKQTNLTTLDLSrnslrvmGNDSFAWLPHLEYLSLEYNNIEHLSSrSFYGLSNLRRLDLRrsftrqS*S 340
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLS-------GNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLS------NNQ 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 341 LTSLPKiddfSFQWLKCLEYLNMDDNNFPGIKrNTFTGLVRLKflslsnsfsslrtltnetFLSLagcpllllnlTKNKI 420
Cdd:COG4886   148 LTDLPE----PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLK------------------ELDL----------SNNQI 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 421 SKIqSGAFSWLGHLEVLDLG---LNEIGQELTGqewrgLDNIVEIYLSYNKYLELTtnSFTSVPSLQRLMLRRVALKNVd 497
Cdd:COG4886   195 TDL-PEPLGNLTNLEELDLSgnqLTDLPEPLAN-----LTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL- 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 498 cspSPFRPLPNLVILDLSNNNIANINDELLKGLEKLEILDLQHNNLARLWKHANPGGPVQFLKGLFHLHILNLGSNGFDE 577
Cdd:COG4886   266 ---PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1875036280 578 IPVEAFKDLRELKSIDLGMNNLNILPQSVFDNQVSLKSLSLQKNLITSVQKTVFGPAFRNLSYLDMRFN 646
Cdd:COG4886   343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
133-368 1.22e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 1.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 133 SNSIQKIKNDPFKNLKNLIKLDLSHNGLSSTKLGTQLQLENLQELLLSNNKISSLTPEEFDFLGNSSLKRLELSSNQIKE 212
Cdd:COG4886     7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 213 FSPGCFHALGELSGLSLNNAKLSPSLTEKLCLELSNTSIEN-------------LSLSSNQLDTIShttfDGLKQ-TNLT 278
Cdd:COG4886    87 LGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDlpeelanltnlkeLDLSNNQLTDLP----EPLGNlTNLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 279 TLDLSRNSLRVMGnDSFAWLPHLEYLSLEYNNIEHLSSrSFYGLSNLRRLDLRRSftrqs*SLTSLPKiddfSFQWLKCL 358
Cdd:COG4886   163 SLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN------QLTDLPE----PLANLTNL 230

                         250
                  ....*....|
gi 1875036280 359 EYLNMDDNNF 368
Cdd:COG4886   231 ETLDLSNNQL 240
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 56-311 4.42e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.71  E-value: 4.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  56 VLNLTHNQLRRLPPANFTRYSQLTILDGGFNSISKLEPE-LCQSlPWLEILNLQHNEISQLSDKTFIFCMNLTELHLMSN 134
Cdd:PLN00113  336 VLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEgLCSS-GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 135 SIQKIKNDPFKNLKNLIKLDLSHNGLSSTKLGTQLQLENLQELLLSNNKISSLTPeefDFLGNSSLKRLELSSNQIKEFS 214
Cdd:PLN00113  415 SFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLP---DSFGSKRLENLDLSRNQFSGAV 491

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 215 PGCFHALGELSGLSLNNAKLSPSLTEklclELSNTSienlslssnqldtishttfdglkqtNLTTLDLSRNSLRVMGNDS 294
Cdd:PLN00113  492 PRKLGSLSELMQLKLSENKLSGEIPD----ELSSCK-------------------------KLVSLDLSHNQLSGQIPAS 542

                         250
                  ....*....|....*..
gi 1875036280 295 FAWLPHLEYLSLEYNNI 311
Cdd:PLN00113  543 FSEMPVLSQLDLSQNQL 559
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 418-541 6.17e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 6.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 418 NKISKIQSgaFSWLGHLEVLDLGLNEIgQELTGQEwrGLDNIVEIYLSYNK-----YLELTTNSFTSV-PSLQRLMLRRv 491
Cdd:cd21340    56 NQIEKIEN--LENLVNLKKLYLGGNRI-SVVEGLE--NLTNLEELHIENQRlppgeKLTFDPRSLAALsNSLRVLNISG- 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1875036280 492 alKNVDcSPSPFRPLPNLVILDLSNNNIANIND--ELLKGLEKLEILDLQHN 541
Cdd:cd21340   130 --NNID-SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
249-311 1.17e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 1.17e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1875036280 249 TSIENLSLSSNQLDTISHTTFDGLKqtNLTTLDLSRNSLRVMGNDSFAWLPHLEYLSLEYNNI 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS--NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
481-543 1.09e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 1.09e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1875036280 481 PSLQRLMLRRVALKNVDcsPSPFRPLPNLVILDLSNNNIANINDELLKGLEKLEILDLQHNNL 543
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-208 5.70e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.41  E-value: 5.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  38 CSHLKLTQIPD-DLPTNITVLNLTHNQLRRLPpaNFTRYSQLTILDGGFNSISKLEPElcQSLPWLEILNLQHNEISQLS 116
Cdd:cd21340     9 LNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRISVVE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 117 --DKtfifCMNLTELHLMSNSI---QKIKNDPFKNL---KNLIKLDLSHNGLSStkLGTQLQLENLQELLLSNNKISSLT 188
Cdd:cd21340    85 glEN----LTNLEELHIENQRLppgEKLTFDPRSLAalsNSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLE 158

                         170       180
                  ....*....|....*....|
gi 1875036280 189 PEEFDFLGNSSLKRLELSSN 208
Cdd:cd21340   159 ELLDLLSSWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 434-648 7.70e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.05  E-value: 7.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 434 LEVLDLGLNEIGQELTG-----QEWRGLDNIVEIYLSYNKYLELTTN---SFTSVPSLQRLMLRR-----VALKNVDCSP 500
Cdd:cd00116    53 LKELCLSLNETGRIPRGlqsllQGLTKGCGLQELDLSDNALGPDGCGvleSLLRSSSLQELKLNNnglgdRGLRLLAKGL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 501 SPfrPLPNLVILDLSNNNIANINDE----LLKGLEKLEILDLQHNNL----ARLWKHAnpggpvqfLKGLFHLHILNLGS 572
Cdd:cd00116   133 KD--LPPALEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIgdagIRALAEG--------LKANCNLEVLDLNN 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 573 NGFDEIPV----EAFKDLRELKSIDLGMNNLNILPQSVFDNQV-----SLKSLSLQKNLIT---SVQKTVFGPAFRNLSY 640
Cdd:cd00116   203 NGLTDEGAsalaETLASLKSLEVLNLGDNNLTDAGAAALASALlspniSLLTLSLSCNDITddgAKDLAEVLAEKESLLE 282


                  ....*...
gi 1875036280 641 LDMRFNPF 648
Cdd:cd00116   283 LDLRGNKF 290
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 72-285 1.11e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  72 FTRYSQLTILDGGFNSISKLEpeLCQSLpwlEILNLQHNEISQLSDktFIFCMNLTELHLMSNSIQKIKNdpFKNLKNLI 151
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLS--LCKNL---KVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 152 KLDLSHNglsstklgtqlqlenlqelllsnnKISSLtpEEFDFLgnSSLKRLELSSNQIKE-----FSPGCFHALGE-LS 225
Cdd:cd21340    72 KLYLGGN------------------------RISVV--EGLENL--TNLEELHIENQRLPPgekltFDPRSLAALSNsLR 123

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 226 GLSLNNAKLSpSLTEKLCLelsnTSIENLSLSSNQLDTISHTTFDGLKQTNLTTLDLSRN 285
Cdd:cd21340   124 VLNISGNNID-SLEPLAPL----RNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
564-623 1.87e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.87e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 564 HLHILNLGSNGFDEIPVEAFKDLRELKSIDLGMNNLNILPQSVFDNQVSLKSLSLQKNLI 623
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
125-210 3.01e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 125 NLTELHLMSNSIQKIKNDPFKNLKNLIKLDLSHnglsstklgtqlqlenlqelllsnNKISSLTPEEFDFLgnSSLKRLE 204
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSN------------------------NLLTTLSPGAFSGL--PSLRYLD 55


                  ....*.
gi 1875036280 205 LSSNQI 210
Cdd:pfam13855  56 LSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 46-543 5.17e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.70  E-value: 5.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  46 IPDDLPTNITVLNLTHNQLRRLPPANFTRYSQLTILDGGFNSISKLEPELCQSLPWLEILNLQHNEISQLSDKTFIFCMN 125
Cdd:PLN00113  134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKS 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 126 LTELHLMSNSIQKIKNDPFKNLKNLIKLDLSHNGLSSTKLGTQLQLENLQELLLSNNKISSLTPEEFDFLGNssLKRLEL 205
Cdd:PLN00113  214 LKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQK--LISLDL 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 206 SSNQIKEFSPGCFHALGELSGLSLNNAKLSPSLTEKLClelSNTSIENLSLSSNQLDtiSHTTFDGLKQTNLTTLDLSRN 285
Cdd:PLN00113  292 SDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALT---SLPRLQVLQLWSNKFS--GEIPKNLGKHNNLTVLDLSTN 366

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 286 SLRVMGNDSFAWLPHLEYLSLEYNNIEHLSSRSFYGLSNLRRLDLrrsftrQS*SLT-SLPKiddfSFQWLKCLEYLNMD 364
Cdd:PLN00113  367 NLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRL------QDNSFSgELPS----EFTKLPLVYFLDIS 436

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 365 DNNFPGikrntftglvRLKFLSLSNSFSSLRTLTNETFLslAGCPLlllnltknkiskiqsgaFSWLGHLEVLDLGLNEI 444
Cdd:PLN00113  437 NNNLQG----------RINSRKWDMPSLQMLSLARNKFF--GGLPD-----------------SFGSKRLENLDLSRNQF 487

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 445 gQELTGQEWRGLDNIVEIYLSYNKYLELTTNSFTSVPSLQRLMLRRVALKNVdcSPSPFRPLPNLVILDLSNNNIANIND 524
Cdd:PLN00113  488 -SGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQ--IPASFSEMPVLSQLDLSQNQLSGEIP 564

                         490
                  ....*....|....*....
gi 1875036280 525 ELLKGLEKLEILDLQHNNL 543
Cdd:PLN00113  565 KNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
52-112 1.12e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.12e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1875036280  52 TNITVLNLTHNQLRRLPPANFTRYSQLTILDGGFNSISKLEPELCQSLPWLEILNLQHNEI 112
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-314 1.24e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.39  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  41 LKLTQIPDDLPTNITVLNLTHNQLRRLPPANFTRYSQLTILDGGFNSISKLEPELcqslpwLEILNLQHNEISQLSDktf 120
Cdd:PRK15370  188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDT------IQEMELSINRITELPE--- 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 121 ifcmnltelHLMSnsiqkikndpfknlkNLIKLDLSHNGLSSTKlgtQLQLENLQELLLSNNKISSLtPEEFDflgnSSL 200
Cdd:PRK15370  259 ---------RLPS---------------ALQSLDLFHNKISCLP---ENLPEELRYLSVYDNSIRTL-PAHLP----SGI 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 201 KRLELSSNQIKeFSPGCFHAlgELSGLSLNNAKLSpSLTEKLCLELsntsiENLSLSSNQLDTISHTtfdgLKQTnLTTL 280
Cdd:PRK15370  307 THLNVQSNSLT-ALPETLPP--GLKTLEAGENALT-SLPASLPPEL-----QVLDVSKNQITVLPET----LPPT-ITTL 372

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1875036280 281 DLSRNSLRVMGNDsfawLP-HLEYLSLEYNNIEHL 314
Cdd:PRK15370  373 DVSRNALTNLPEN----LPaALQIMQASRNNLVRL 403
LRR_8 pfam13855
Leucine rich repeat;
102-160 2.02e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 2.02e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1875036280 102 LEILNLQHNEISQLSDKTFIFCMNLTELHLMSNSIQKIKNDPFKNLKNLIKLDLSHNGL 160
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 197-367 3.93e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.66  E-value: 3.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 197 NSSLKRLELSSNQIKEFSPG---CFHALGELSGL---SLNNAKLSPSLTEKLCLELSNTSIENLSLSSNQL-DTISHTTF 269
Cdd:cd00116    50 QPSLKELCLSLNETGRIPRGlqsLLQGLTKGCGLqelDLSDNALGPDGCGVLESLLRSSSLQELKLNNNGLgDRGLRLLA 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 270 DGLK--QTNLTTLDLSRNSLRvmGNDSFAW---LPH---LEYLSLEYNN-----IEHLsSRSFYGLSNLRRLDLRRS-FT 335
Cdd:cd00116   130 KGLKdlPPALEKLVLGRNRLE--GASCEALakaLRAnrdLKELNLANNGigdagIRAL-AEGLKANCNLEVLDLNNNgLT 206

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1875036280 336 RQS*SLTSLpkiddfSFQWLKCLEYLNMDDNN 367
Cdd:cd00116   207 DEGASALAE------TLASLKSLEVLNLGDNN 232
Tlr3_TMD pfam17968
Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR ...
 699-731 6.65e-06

Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. This entry represents the Toll-like receptor 3 trans-membrane domain which has been shown to form dimers and trimers with different surfaces for helix-helix interaction.


Pssm-ID: 465595  Cd Length: 33  Bit Score: 43.45  E-value: 6.65e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1875036280 699 DSAPFELLFMININILLIFIFIVLLIHFEGWRI 731
Cdd:pfam17968   1 DSAPFKLLFVISSTAVLLFIFIVLLIHFQGWRI 33
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 787-880 9.66e-06

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 46.59  E-value: 9.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 787 CLEERDFEAGVLELEAIVNSIRRSRKIIFVVTQNLLKDPLCKsFKVHHAVQQAIEQNLdSIILIFLEEIPDYKLNHALCL 866
Cdd:pfam01582  32 FIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCL-DELVKILECALDLGQ-KVIPIFYEVDPSDVRKQTGSF 109

                          90       100
                  ....*....|....*....|.
gi 1875036280 867 RRGmFKSHC-------ILNWP 880
Cdd:pfam01582 110 GKA-FKKHKkvlteekVLKWR 129
LRR_8 pfam13855
Leucine rich repeat;
76-136 1.02e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1875036280  76 SQLTILDGGFNSISKLEPELCQSLPWLEILNLQHNEISQLSDKTFIFCMNLTELHLMSNSI 136
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 249-368 2.17e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 2.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 249 TSIENLS---------LSSNQLDTISHTTFdglkQTNLTTLDLSRNSLRVMGNdsFAWLPHLEYLSLEYNNIEHLSsrSF 319
Cdd:cd21340    15 TKIDNLSlcknlkvlyLYDNKITKIENLEF----LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE--GL 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1875036280 320 YGLSNLR-------RLDLRRSFTRQS*SLTSLP-----------KIDDFS-FQWLKCLEYLNMDDNNF 368
Cdd:cd21340    87 ENLTNLEelhienqRLPPGEKLTFDPRSLAALSnslrvlnisgnNIDSLEpLAPLRNLEQLDASNNQI 154
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
468-692 2.49e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 2.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 468 KYLELTTNSFTSVPSLQRLMLRRVALKNVDCSPSPFRpLPN-LVILDLSNNNIANINDELLKGLEKLEILDlqhNNLARL 546
Cdd:PRK15370  223 KTLYANSNQLTSIPATLPDTIQEMELSINRITELPER-LPSaLQSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTL 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 547 WKHAnPGGPVQ---------FLKGLF--HLHILNLGSNGFDEIPvEAFKDlrELKSIDLGMNNLNILPQSVfdnQVSLKS 615
Cdd:PRK15370  299 PAHL-PSGITHlnvqsnsltALPETLppGLKTLEAGENALTSLP-ASLPP--ELQVLDVSKNQITVLPETL---PPTITT 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 616 LSLQKNLITSVQKTVfgPAfrNLSYLDMRFNPFDCTCESIAWFVN------WINITHTNISE--LSNHYLCNTPPQYHGy 687
Cdd:PRK15370  372 LDVSRNALTNLPENL--PA--ALQIMQASRNNLVRLPESLPHFRGegpqptRIIVEYNPFSErtIQNMQRLMSSVGYQG- 446


                  ....*
gi 1875036280 688 PVMLF 692
Cdd:PRK15370  447 PRVLF 451
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 503-628 5.59e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 5.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 503 FRPLPNLVILDLSNNNIANIndELLKGLEKLEILDLQHNNLArlwkhanPGGPVQF----LKGLFH-LHILNLGSNGFDE 577
Cdd:cd21340    64 LENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLP-------PGEKLTFdprsLAALSNsLRVLNISGNNIDS 134

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1875036280 578 IpvEAFKDLRELKSIDLGMNNLNILPQ--SVFDNQVSLKSLSLQKNLITSVQK 628
Cdd:cd21340   135 L--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
507-599 9.03e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 9.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 507 PNLVILDLSNNNIANINDELLKGLEKLEILDLQHNNLarlwkhanpggpvqflkglfhlhilnlgsngfDEIPVEAFKDL 586
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--------------------------------TTLSPGAFSGL 48

                          90
                  ....*....|...
gi 1875036280 587 RELKSIDLGMNNL 599
Cdd:pfam13855  49 PSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
646-698 3.08e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 3.08e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1875036280  646 NPFDCTCEsIAWFVNWINitHTNISELSNHYLCNTPPQYHGyPV--MLFDVSPCK 698
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQ--ANEHLQDPVDLRCASPSSLRG-PLleLLHSEFKCP 51
PLN03150 PLN03150
hypothetical protein; Provisional
 45-113 3.17e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 3.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1875036280  45 QIPDDLPT--NITVLNLTHNQLRRLPPANFTRYSQLTILDGGFNSISKLEPELCQSLPWLEILNLQHNEIS 113
Cdd:PLN03150  433 FIPNDISKlrHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
LRR_8 pfam13855
Leucine rich repeat;
587-648 3.98e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 3.98e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1875036280 587 RELKSIDLGMNNLNILPQSVFDNQVSLKSLSLQKNLITSVQKTVFGPaFRNLSYLDMRFNPF 648
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG-LPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 507-543 4.38e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 4.38e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1875036280 507 PNLVILDLSNNNIANIndELLKGLEKLEILDLQHNNL 543
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNK 35
LRR_8 pfam13855
Leucine rich repeat;
180-231 4.99e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 4.99e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1875036280 180 SNNKISSLTPEEFdfLGNSSLKRLELSSNQIKEFSPGCFHALGELSGLSLNN 231
Cdd:pfam13855   9 SNNRLTSLDDGAF--KGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR_8 pfam13855
Leucine rich repeat;
416-468 7.93e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 7.93e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1875036280 416 TKNKISKIQSGAFSWLGHLEVLDLGLNEIgQELTGQEWRGLDNIVEIYLSYNK 468
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 618-690 9.98e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.15  E-value: 9.98e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1875036280  618 LQKNLITSVQKTVFGPAFrNLSYLDMRFNPFDCTCeSIAWFVNWINITHTNISElSNHYLCNTPPQYHGYPVM 690
Cdd:TIGR00864    2 ISNNKISTIEEGICANLC-NLSEIDLSGNPFECDC-GLARLPRWAEEKGVKVRQ-PEAALCAGPGALAGQPLL 71
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 247-376 1.96e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 247 SNTSIENLSLSSNqLDTISHTTFDGLkqTNLTTLDLSrNSLRVMGNDSFAWLPhLEYLSLEyNNIEHLSSRSFYGLSNLR 326
Cdd:pfam13306   9 YNCSLTSITIPSS-LTSIGEYAFSNC--TSLKSITLP-SSLTSIGSYAFYNCS-LTSITIP-SSLTSIGEYAFSNCSNLK 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1875036280 327 RLDLRRSFTrqs*sltslpKIDDFSFQwlKC-LEYLNMDDNNFPgIKRNTF 376
Cdd:pfam13306  83 SITLPSNLT----------SIGSYAFS--NCsLKSITIPSSVTT-IGSYAF 120
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 13-208 2.16e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  13 SGLLTCWILCTSSAHKcTVRHEVADCSHLKLTQIPD-----DLPTNIT------VLNLTHNQLRRLPPANFTRYSQLTIL 81
Cdd:PLN00113  379 SGNLFKLILFSNSLEG-EIPKSLGACRSLRRVRLQDnsfsgELPSEFTklplvyFLDISNNNLQGRINSRKWDMPSLQML 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  82 DGGFNSISKLEPELCQSlPWLEILNLQHNEISQLSDKTFIFCMNLTELHLMSNSIQKIKNDPFKNLKNLIKLDLSHNGLS 161
Cdd:PLN00113  458 SLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1875036280 162 STKLGTQLQLENLQELLLSNNKISSLTPEEfdfLGN-SSLKRLELSSN 208
Cdd:PLN00113  537 GQIPASFSEMPVLSQLDLSQNQLSGEIPKN---LGNvESLVQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
198-287 2.51e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 198 SSLKRLELSSNQIKEFSPGCFHALgelsglslnnaklsPSLTEklclelsntsienLSLSSNQLDTISHTTFDGLKqtNL 277
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGL--------------SNLKV-------------LDLSNNLLTTLSPGAFSGLP--SL 51

                          90
                  ....*....|
gi 1875036280 278 TTLDLSRNSL 287
Cdd:pfam13855  52 RYLDLSGNRL 61
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 197-326 4.97e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.91  E-value: 4.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 197 NSSLKRLELSSNqIKEFSPGCFHALgelsgLSLNNAKLSPSLTEklcLE---LSNTSIENLSLSSNqLDTISHTTFDGLk 273
Cdd:pfam13306  10 NCSLTSITIPSS-LTSIGEYAFSNC-----TSLKSITLPSSLTS---IGsyaFYNCSLTSITIPSS-LTSIGEYAFSNC- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1875036280 274 qTNLTTLDLSrNSLRVMGNDSFAwlphleYLSLEY----NNIEHLSSRSFYGLSNLR 326
Cdd:pfam13306  79 -SNLKSITLP-SNLTSIGSYAFS------NCSLKSitipSSVTTIGSYAFSNCSNLK 127
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 759-852 7.56e-03

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 37.29  E-value: 7.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 759 YIIHAYKDRDWVwkhfspmEE-----EDHTLRFCLEERDFEAGVLELEAIVNSIRRSRKIIFVVTQNLLKDPLCksfkvH 833
Cdd:pfam13676   2 FISYAGEDRAWA-------EWladalEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWC-----R 69

                          90
                  ....*....|....*....
gi 1875036280 834 HAVQQAIEQNLDSIILIFL 852
Cdd:pfam13676  70 AEWEAALADPEGRKRLIPV 88
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 96-330 7.64e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 7.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280  96 CQSLPWLEILNLQHNEISQLSDKTFIFCMNLTElhlMSNSIQKIKNDPFKNLKNLIKLDLSHNGLSSTKLGTQLqlenlq 175
Cdd:cd00116    32 GNTLGEEAAKALASALRPQPSLKELCLSLNETG---RIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLE------ 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 176 elllsnnkissltpeefDFLGNSSLKRLELSSNQIkEFSPG---------CFHALGELsGLSLNNakLSPSLTEKLCLEL 246
Cdd:cd00116   103 -----------------SLLRSSSLQELKLNNNGL-GDRGLrllakglkdLPPALEKL-VLGRNR--LEGASCEALAKAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1875036280 247 -SNTSIENLSLSSNQL-DTISHTTFDGLK-QTNLTTLDLSRNSLRVMG----NDSFAWLPHLEYLSLEYNNIE-----HL 314
Cdd:cd00116   162 rANRDLKELNLANNGIgDAGIRALAEGLKaNCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTdagaaAL 241

                         250
                  ....*....|....*.
gi 1875036280 315 SSRSFYGLSNLRRLDL 330
Cdd:cd00116   242 ASALLSPNISLLTLSL 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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