NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|928505948|sp|Q9QZ04|]
View 

RecName: Full=MAGE-like protein 2; AltName: Full=Protein nS7

Protein Classification

MAGE domain-containing protein( domain architecture ID 10477727)

MAGE (Melanoma-associated antigen) domain-containing protein similar to human melanoma-associated antigen F1 and non-structural maintenance of chromosomes element 3 homolog

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
1059-1223 7.91e-19

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


:

Pssm-ID: 426270  Cd Length: 205  Bit Score: 86.17  E-value: 7.91e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  1059 LVQFLLVKDQAKVPVQLSEMVNVVIREYKDDSLD-IINRANTKLECTFGCQLKEVDTK--------------------TH 1117
Cdd:pfam01454    1 LVRYALACEYQRTPIRREDISKKVLGENRKRLFKkVFEEAQKILRDVFGMELVELPAKeekkttvtsqqrraaakssrSK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  1118 TYIIVNKMayPQCNLLASYLERPKFS-------------LLMVVLSLIFMKGYCIRENLLFSFLFQLGLD---VQETSGL 1181
Cdd:pfam01454   81 SYILVSTL--PPEYRVPAIIWPSKAPsfvldqdeatytgILTVILSLILLSGGSISEQELLRYLRRLGIDtdgTKEIPPL 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 928505948  1182 FRITKKLITSvFVRHRYLEYRQIPFTEPAE--YELLWGPRAFLE 1223
Cdd:pfam01454  159 NGNTDDLLKR-LVKQGYLVRTKEGASDDGEeiIEYRVGPRAKVE 201
PHA03247 super family cl33720
large tegument protein UL36; Provisional
190-675 5.07e-15

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 80.75  E-value: 5.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  190 PPPGNPMTHPPPGNPMVHPlthgapmvhggPHGTPMPHVPITGTPiAQQPTPGVLMAQQLTPGVLMVQPPAPGAPmVQPP 269
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPP-----------PRPAPRPSEPAVTSR-ARRPDAPPQSARPRAPVDDRGDPRGPAPP-SPLP 2618
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  270 PQAALMTQPAPSITPMAKPPGPGVVMIHPPGARGPIIQTPVSGAPMAQTVLP-----PGQPLATWAPQGQPLILQIQSQV 344
Cdd:PHA03247 2619 PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLgraaqASSPPQRPRRRAARPTVGSLTSL 2698
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  345 IRAPPQVPSVPQAPQVQLATPPgwqaTTPNWQVTPQGWPATPLTWQATQVTWQAPTIAWQATQPGRQGHSTIRTGHTPIR 424
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATP----LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  425 PGPAPLLRQIPPMIRQIQPVMRQAPplirqVPIRPAPHGIASQPqlwqvLPPPPPLRQAPQArlllPRVPGTGQVSTVPP 504
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLP-----SPWDPADPPAAVLA-----PAAALPPAASPAG----PLPPPTSAQPTAPP 2840
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  505 vaqihlvPQSGPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPIIWQAPKGQAPVPQELPVPQELPVPQELPVPQEVP 584
Cdd:PHA03247 2841 -------PPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQA 2913
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  585 VPQEIPVPQEIPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPlEFQEVQQAQAVGWRAPK 664
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVP-RFRVPQPAPSREAPASS 2992
                         490
                  ....*....|.
gi 928505948  665 VPPHFWQPVSA 675
Cdd:PHA03247 2993 TPPLTGHSLSR 3003
PHA03247 super family cl33720
large tegument protein UL36; Provisional
2-313 1.71e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 62.65  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948    2 SQLSTNLGDSSPPESPVPAVhSRPTVLMRA----PPASSRAPPVPWDPPPVDLQAPMAAWQAPQPAWEAPEGQLPAPVAQ 77
Cdd:PHA03247 2668 RRLGRAAQASSPPQRPRRRA-ARPTVGSLTsladPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   78 LAQPPGLGAPmVQAPPLGGGMAKPPTPGVlmvhqpPPGAPMAQSSTPGVLMLHPSVTGAPLA-----HPPPPGTPMTHPP 152
Cdd:PHA03247 2747 GPATPGGPAR-PARPPTTAGPPAPAPPAA------PAAGPPRRLTRPAVASLSESRESLPSPwdpadPPAAVLAPAAALP 2819
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  153 GTSMAHPPPPPPPPPPPPPPGTPMTHPPPPGTPMGHHPPPGNPMTHPPPGNPMVHPLTHGAPMVhggpHGTPMPHVPITG 232
Cdd:PHA03247 2820 PAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPV----RRLARPAVSRST 2895
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  233 TPIAQQPTPgvlmaQQLTPgvlmvQPPAPGAPMVQPPPQAALMTQPAPSITPMAKPPGPGVVMIHPPGARGPIIQTPVSG 312
Cdd:PHA03247 2896 ESFALPPDQ-----PERPP-----QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG 2965

                  .
gi 928505948  313 A 313
Cdd:PHA03247 2966 A 2966
PHA03247 super family cl33720
large tegument protein UL36; Provisional
512-931 1.27e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 1.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  512 PQSGPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPiiwqAPKGQAPVPQELPVPQELPVPqELPVPQEVPVPQEIPV 591
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP----PPPSPSPAANEPDPHPPPTVP-PPERPRDDPAPGRVSR 2663
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  592 PQEIPVPQELPVPQElpvPQELPVPQELPVP-------QELPVPQELPVPQELPVPQELPVPLEFQEVQQAQAVGWRAPK 664
Cdd:PHA03247 2664 PRRARRLGRAAQASS---PPQRPRRRAARPTvgsltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPA 2740
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  665 VPPHFWQPVSAQEAQEQATQIAhveQQQPFQGAPASSKALQTQLPTHQAQASGLQAELPSVQLQPSWQGP----LPMLQA 740
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPT---TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPpaavLAPAAA 2817
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  741 QPGASATLANFPRGSTRSRMAPSGEPGPssLEPRGPPRERRAPARD--KKGPPKERMFIGATFCAPRGASASRAYVPTAW 818
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAQPTAPPPPPGP--PPPSLPLGGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  819 KNLPatsetFPATSRVFPSTSHFQPASSNAFRGPSAASESPKSLPFALQDPYACVEALPAVPWVPYPDGNASSACKSVPA 898
Cdd:PHA03247 2896 ESFA-----LPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPG 2970
                         410       420       430
                  ....*....|....*....|....*....|...
gi 928505948  899 ILMVAAAAPQASATAAEASKSSEPPRRPGKATR 931
Cdd:PHA03247 2971 RVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
1059-1223 7.91e-19

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 86.17  E-value: 7.91e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  1059 LVQFLLVKDQAKVPVQLSEMVNVVIREYKDDSLD-IINRANTKLECTFGCQLKEVDTK--------------------TH 1117
Cdd:pfam01454    1 LVRYALACEYQRTPIRREDISKKVLGENRKRLFKkVFEEAQKILRDVFGMELVELPAKeekkttvtsqqrraaakssrSK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  1118 TYIIVNKMayPQCNLLASYLERPKFS-------------LLMVVLSLIFMKGYCIRENLLFSFLFQLGLD---VQETSGL 1181
Cdd:pfam01454   81 SYILVSTL--PPEYRVPAIIWPSKAPsfvldqdeatytgILTVILSLILLSGGSISEQELLRYLRRLGIDtdgTKEIPPL 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 928505948  1182 FRITKKLITSvFVRHRYLEYRQIPFTEPAE--YELLWGPRAFLE 1223
Cdd:pfam01454  159 NGNTDDLLKR-LVKQGYLVRTKEGASDDGEeiIEYRVGPRAKVE 201
PHA03247 PHA03247
large tegument protein UL36; Provisional
190-675 5.07e-15

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 80.75  E-value: 5.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  190 PPPGNPMTHPPPGNPMVHPlthgapmvhggPHGTPMPHVPITGTPiAQQPTPGVLMAQQLTPGVLMVQPPAPGAPmVQPP 269
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPP-----------PRPAPRPSEPAVTSR-ARRPDAPPQSARPRAPVDDRGDPRGPAPP-SPLP 2618
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  270 PQAALMTQPAPSITPMAKPPGPGVVMIHPPGARGPIIQTPVSGAPMAQTVLP-----PGQPLATWAPQGQPLILQIQSQV 344
Cdd:PHA03247 2619 PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLgraaqASSPPQRPRRRAARPTVGSLTSL 2698
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  345 IRAPPQVPSVPQAPQVQLATPPgwqaTTPNWQVTPQGWPATPLTWQATQVTWQAPTIAWQATQPGRQGHSTIRTGHTPIR 424
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATP----LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  425 PGPAPLLRQIPPMIRQIQPVMRQAPplirqVPIRPAPHGIASQPqlwqvLPPPPPLRQAPQArlllPRVPGTGQVSTVPP 504
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLP-----SPWDPADPPAAVLA-----PAAALPPAASPAG----PLPPPTSAQPTAPP 2840
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  505 vaqihlvPQSGPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPIIWQAPKGQAPVPQELPVPQELPVPQELPVPQEVP 584
Cdd:PHA03247 2841 -------PPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQA 2913
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  585 VPQEIPVPQEIPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPlEFQEVQQAQAVGWRAPK 664
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVP-RFRVPQPAPSREAPASS 2992
                         490
                  ....*....|.
gi 928505948  665 VPPHFWQPVSA 675
Cdd:PHA03247 2993 TPPLTGHSLSR 3003
PHA03247 PHA03247
large tegument protein UL36; Provisional
2-313 1.71e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 62.65  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948    2 SQLSTNLGDSSPPESPVPAVhSRPTVLMRA----PPASSRAPPVPWDPPPVDLQAPMAAWQAPQPAWEAPEGQLPAPVAQ 77
Cdd:PHA03247 2668 RRLGRAAQASSPPQRPRRRA-ARPTVGSLTsladPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   78 LAQPPGLGAPmVQAPPLGGGMAKPPTPGVlmvhqpPPGAPMAQSSTPGVLMLHPSVTGAPLA-----HPPPPGTPMTHPP 152
Cdd:PHA03247 2747 GPATPGGPAR-PARPPTTAGPPAPAPPAA------PAAGPPRRLTRPAVASLSESRESLPSPwdpadPPAAVLAPAAALP 2819
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  153 GTSMAHPPPPPPPPPPPPPPGTPMTHPPPPGTPMGHHPPPGNPMTHPPPGNPMVHPLTHGAPMVhggpHGTPMPHVPITG 232
Cdd:PHA03247 2820 PAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPV----RRLARPAVSRST 2895
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  233 TPIAQQPTPgvlmaQQLTPgvlmvQPPAPGAPMVQPPPQAALMTQPAPSITPMAKPPGPGVVMIHPPGARGPIIQTPVSG 312
Cdd:PHA03247 2896 ESFALPPDQ-----PERPP-----QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG 2965

                  .
gi 928505948  313 A 313
Cdd:PHA03247 2966 A 2966
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
332-784 9.19e-09

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 60.17  E-value: 9.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   332 QGQPLILQIQSQVIRAPPqvPSVPQAPQVQLATPPGWQATTPnwqvtPQGWPATPLTWQATQVTWQAPTIAWQATQPgrq 411
Cdd:pfam03154  168 QTQPPVLQAQSGAASPPS--PPPPGTTQAATAGPTPSAPSVP-----PQGSPATSQPPNQTQSTAAPHTLIQQTPTL--- 237
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   412 ghstirtgHTPIRPGPAPLLRQIPPMIRQIQPVMRQAPPLIRQVPIRPAPHGIASQPQLWQvlppppplrqapqarlllp 491
Cdd:pfam03154  238 --------HPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQ------------------- 290
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   492 rvpgtgqvstvppvaqiHLVPQSGpqVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPIIWQAPKGQAPVPQELPvPQEL 571
Cdd:pfam03154  291 -----------------HPVPPQP--FPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLP-PAPL 350
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   572 PVPQELPvPQEVPVPQeipvpqeIPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQElpvPQELPVPLEFQE 651
Cdd:pfam03154  351 SMPHIKP-PPTTPIPQ-------LPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHP---PSAHPPPLQLMP 419
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   652 VQQaqavgwraPKVPPHFWQPVSAQEAQEQATQIAHVEQQQPFQGAPasskalQTQLPTHQAQASGLQAELPSVQLQPSW 731
Cdd:pfam03154  420 QSQ--------QLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPS------QSPFPQHPFVPGGPPPITPPSGPPTST 485
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 928505948   732 QGPLPMLQAQPGASATLANFPRGSTRSRMAP---SGEPGPSSLEPRGPPRERRAPA 784
Cdd:pfam03154  486 SSAMPGIQPPSSASVSSSGPVPAAVSCPLPPvqiKEEALDEAEEPESPPPPPRSPS 541
PHA03247 PHA03247
large tegument protein UL36; Provisional
512-931 1.27e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 1.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  512 PQSGPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPiiwqAPKGQAPVPQELPVPQELPVPqELPVPQEVPVPQEIPV 591
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP----PPPSPSPAANEPDPHPPPTVP-PPERPRDDPAPGRVSR 2663
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  592 PQEIPVPQELPVPQElpvPQELPVPQELPVP-------QELPVPQELPVPQELPVPQELPVPLEFQEVQQAQAVGWRAPK 664
Cdd:PHA03247 2664 PRRARRLGRAAQASS---PPQRPRRRAARPTvgsltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPA 2740
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  665 VPPHFWQPVSAQEAQEQATQIAhveQQQPFQGAPASSKALQTQLPTHQAQASGLQAELPSVQLQPSWQGP----LPMLQA 740
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPT---TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPpaavLAPAAA 2817
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  741 QPGASATLANFPRGSTRSRMAPSGEPGPssLEPRGPPRERRAPARD--KKGPPKERMFIGATFCAPRGASASRAYVPTAW 818
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAQPTAPPPPPGP--PPPSLPLGGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  819 KNLPatsetFPATSRVFPSTSHFQPASSNAFRGPSAASESPKSLPFALQDPYACVEALPAVPWVPYPDGNASSACKSVPA 898
Cdd:PHA03247 2896 ESFA-----LPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPG 2970
                         410       420       430
                  ....*....|....*....|....*....|...
gi 928505948  899 ILMVAAAAPQASATAAEASKSSEPPRRPGKATR 931
Cdd:PHA03247 2971 RVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
526-647 8.57e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 43.64  E-value: 8.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   526 QLSIPIPVPQAAAQSAPRTVH------CPPIIWQA----PKGQAPVPQELPVPQELPVPQELPVPQEVPVPQEIPVP--Q 593
Cdd:TIGR01628  384 QLPMGSPMGGAMGQPPYYGQGpqqqfnGQPLGWPRmsmmPTPMGPGGPLRPNGLAPMNAVRAPSRNAQNAAQKPPMQpvM 463
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 928505948   594 EIPVPQELPVPQELPVPQELPVpQELPVPQELPVPQELPVPQELPVPQELPVPL 647
Cdd:TIGR01628  464 YPPNYQSLPLSQDLPQPQSTAS-QGGQNKKLAQVLASATPQMQKQVLGERLFPL 516
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
1059-1223 7.91e-19

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 86.17  E-value: 7.91e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  1059 LVQFLLVKDQAKVPVQLSEMVNVVIREYKDDSLD-IINRANTKLECTFGCQLKEVDTK--------------------TH 1117
Cdd:pfam01454    1 LVRYALACEYQRTPIRREDISKKVLGENRKRLFKkVFEEAQKILRDVFGMELVELPAKeekkttvtsqqrraaakssrSK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  1118 TYIIVNKMayPQCNLLASYLERPKFS-------------LLMVVLSLIFMKGYCIRENLLFSFLFQLGLD---VQETSGL 1181
Cdd:pfam01454   81 SYILVSTL--PPEYRVPAIIWPSKAPsfvldqdeatytgILTVILSLILLSGGSISEQELLRYLRRLGIDtdgTKEIPPL 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 928505948  1182 FRITKKLITSvFVRHRYLEYRQIPFTEPAE--YELLWGPRAFLE 1223
Cdd:pfam01454  159 NGNTDDLLKR-LVKQGYLVRTKEGASDDGEeiIEYRVGPRAKVE 201
PHA03247 PHA03247
large tegument protein UL36; Provisional
190-675 5.07e-15

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 80.75  E-value: 5.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  190 PPPGNPMTHPPPGNPMVHPlthgapmvhggPHGTPMPHVPITGTPiAQQPTPGVLMAQQLTPGVLMVQPPAPGAPmVQPP 269
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPP-----------PRPAPRPSEPAVTSR-ARRPDAPPQSARPRAPVDDRGDPRGPAPP-SPLP 2618
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  270 PQAALMTQPAPSITPMAKPPGPGVVMIHPPGARGPIIQTPVSGAPMAQTVLP-----PGQPLATWAPQGQPLILQIQSQV 344
Cdd:PHA03247 2619 PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLgraaqASSPPQRPRRRAARPTVGSLTSL 2698
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  345 IRAPPQVPSVPQAPQVQLATPPgwqaTTPNWQVTPQGWPATPLTWQATQVTWQAPTIAWQATQPGRQGHSTIRTGHTPIR 424
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATP----LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  425 PGPAPLLRQIPPMIRQIQPVMRQAPplirqVPIRPAPHGIASQPqlwqvLPPPPPLRQAPQArlllPRVPGTGQVSTVPP 504
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLP-----SPWDPADPPAAVLA-----PAAALPPAASPAG----PLPPPTSAQPTAPP 2840
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  505 vaqihlvPQSGPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPIIWQAPKGQAPVPQELPVPQELPVPQELPVPQEVP 584
Cdd:PHA03247 2841 -------PPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQA 2913
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  585 VPQEIPVPQEIPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPlEFQEVQQAQAVGWRAPK 664
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVP-RFRVPQPAPSREAPASS 2992
                         490
                  ....*....|.
gi 928505948  665 VPPHFWQPVSA 675
Cdd:PHA03247 2993 TPPLTGHSLSR 3003
PHA03247 PHA03247
large tegument protein UL36; Provisional
9-429 6.02e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 74.20  E-value: 6.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948    9 GDSSPPESPVPAVHSRPTVLMRAPPASSRAPPVPWDPPPVDLQAPMAAWQAPQPAweAPEGQLPAPVAQLAQPPGLGAPM 88
Cdd:PHA03247 2603 DDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPA--PGRVSRPRRARRLGRAAQASSPP 2680
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   89 VQAPPlgggMAKPPTPGVL--MVHQPPPGAPMAQSSTPGV--LMLHPSVTGAPLAHPPPPGTPMTHPPGTSMAHPPPPPP 164
Cdd:PHA03247 2681 QRPRR----RAARPTVGSLtsLADPPPPPPTPEPAPHALVsaTPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPAR 2756
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  165 PPPPPPPPGTPMTHPPPPgtpmghhPPPGNPMTHPPPGNPMVHPLTHGAPMV-----HGGPHGTPMPHVPITGTPIAQQP 239
Cdd:PHA03247 2757 PARPPTTAGPPAPAPPAA-------PAAGPPRRLTRPAVASLSESRESLPSPwdpadPPAAVLAPAAALPPAASPAGPLP 2829
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  240 TPgvlMAQQLTPGVLMVQPPAPGAPMVQPPPQAALMTQPAPSITPMAKPPGPGvvmiHPPGARGPIIQTPVSGAPMAQTV 319
Cdd:PHA03247 2830 PP---TSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPA----RPPVRRLARPAVSRSTESFALPP 2902
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  320 LPPgQPLATWAPQGQPLilqiqsqvIRAPPQVPSVPQAPQVQLATPPGWQATTPNWQVTPQGWPATPLTWQATQVTWQAP 399
Cdd:PHA03247 2903 DQP-ERPPQPQAPPPPQ--------PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVA 2973
                         410       420       430
                  ....*....|....*....|....*....|
gi 928505948  400 TIAWQATQPgrqghstirtghTPIRPGPAP 429
Cdd:PHA03247 2974 VPRFRVPQP------------APSREAPAS 2991
PHA03247 PHA03247
large tegument protein UL36; Provisional
14-586 1.36e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 1.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   14 PESPV---PAVHSRPTVLMRAPPASSRAPPVPWDPppvdlqaPMAAWQAPQPAWEAPEGQlPAPVAQLAQPPGL------ 84
Cdd:PHA03247 2475 PGAPVyrrPAEARFPFAAGAAPDPGGGGPPDPDAP-------PAPSRLAPAILPDEPVGE-PVHPRMLTWIRGLeelasd 2546
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   85 --GAPMVQAPPLgggmAKPPTPGvlmvHQPPPGAPMAQSSTPGVLM--LHPSVTGAPlAHPPPPGTPMTHPPGTSMAHPP 160
Cdd:PHA03247 2547 daGDPPPPLPPA----APPAAPD----RSVPPPRPAPRPSEPAVTSraRRPDAPPQS-ARPRAPVDDRGDPRGPAPPSPL 2617
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  161 PPPPPPPPPPPPGTPMTHPPPPGTPMGHHPPPGNPMTHPPPGNPMVHPLTHgapmvhgGPHGTPMPHVPITG-TPIAQQP 239
Cdd:PHA03247 2618 PPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR-------RLGRAAQASSPPQRpRRRAARP 2690
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  240 TPGVLMAqqltpgvlMVQPPAPGaPMVQPPPQAALMTQPAPSITPMAKP--PGPGVVMIHPPGARGPIiqTPVSGAPMAQ 317
Cdd:PHA03247 2691 TVGSLTS--------LADPPPPP-PTPEPAPHALVSATPLPPGPAAARQasPALPAAPAPPAVPAGPA--TPGGPARPAR 2759
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  318 TVLPPGQPLATwAPQGQPLILQIQSQVIRAPPQVPSVPQAPQVQLATPPGWQATTPNWQVTPQGWPATPLtwqatqvtwq 397
Cdd:PHA03247 2760 PPTTAGPPAPA-PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL---------- 2828
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  398 APTIAWQATQPgrqghstirtghtPIRPGPAPLLRQIPPMIRQIQPVMRQAPPliRQVPIRPAPhgiASQPQLWQVLPPP 477
Cdd:PHA03247 2829 PPPTSAQPTAP-------------PPPPGPPPPSLPLGGSVAPGGDVRRRPPS--RSPAAKPAA---PARPPVRRLARPA 2890
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  478 PPLRQAPQArlllprVPGTGQVSTVPPVAQIHLVPQSGPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPIIWQAPKG 557
Cdd:PHA03247 2891 VSRSTESFA------LPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL 2964
                         570       580
                  ....*....|....*....|....*....
gi 928505948  558 QAPVPQELPVPQELpVPQELPvPQEVPVP 586
Cdd:PHA03247 2965 GALVPGRVAVPRFR-VPQPAP-SREAPAS 2991
PHA03247 PHA03247
large tegument protein UL36; Provisional
2-313 1.71e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 62.65  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948    2 SQLSTNLGDSSPPESPVPAVhSRPTVLMRA----PPASSRAPPVPWDPPPVDLQAPMAAWQAPQPAWEAPEGQLPAPVAQ 77
Cdd:PHA03247 2668 RRLGRAAQASSPPQRPRRRA-ARPTVGSLTsladPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   78 LAQPPGLGAPmVQAPPLGGGMAKPPTPGVlmvhqpPPGAPMAQSSTPGVLMLHPSVTGAPLA-----HPPPPGTPMTHPP 152
Cdd:PHA03247 2747 GPATPGGPAR-PARPPTTAGPPAPAPPAA------PAAGPPRRLTRPAVASLSESRESLPSPwdpadPPAAVLAPAAALP 2819
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  153 GTSMAHPPPPPPPPPPPPPPGTPMTHPPPPGTPMGHHPPPGNPMTHPPPGNPMVHPLTHGAPMVhggpHGTPMPHVPITG 232
Cdd:PHA03247 2820 PAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPV----RRLARPAVSRST 2895
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  233 TPIAQQPTPgvlmaQQLTPgvlmvQPPAPGAPMVQPPPQAALMTQPAPSITPMAKPPGPGVVMIHPPGARGPIIQTPVSG 312
Cdd:PHA03247 2896 ESFALPPDQ-----PERPP-----QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG 2965

                  .
gi 928505948  313 A 313
Cdd:PHA03247 2966 A 2966
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
332-784 9.19e-09

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 60.17  E-value: 9.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   332 QGQPLILQIQSQVIRAPPqvPSVPQAPQVQLATPPGWQATTPnwqvtPQGWPATPLTWQATQVTWQAPTIAWQATQPgrq 411
Cdd:pfam03154  168 QTQPPVLQAQSGAASPPS--PPPPGTTQAATAGPTPSAPSVP-----PQGSPATSQPPNQTQSTAAPHTLIQQTPTL--- 237
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   412 ghstirtgHTPIRPGPAPLLRQIPPMIRQIQPVMRQAPPLIRQVPIRPAPHGIASQPQLWQvlppppplrqapqarlllp 491
Cdd:pfam03154  238 --------HPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQ------------------- 290
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   492 rvpgtgqvstvppvaqiHLVPQSGpqVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPIIWQAPKGQAPVPQELPvPQEL 571
Cdd:pfam03154  291 -----------------HPVPPQP--FPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLP-PAPL 350
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   572 PVPQELPvPQEVPVPQeipvpqeIPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQElpvPQELPVPLEFQE 651
Cdd:pfam03154  351 SMPHIKP-PPTTPIPQ-------LPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHP---PSAHPPPLQLMP 419
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   652 VQQaqavgwraPKVPPHFWQPVSAQEAQEQATQIAHVEQQQPFQGAPasskalQTQLPTHQAQASGLQAELPSVQLQPSW 731
Cdd:pfam03154  420 QSQ--------QLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPS------QSPFPQHPFVPGGPPPITPPSGPPTST 485
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 928505948   732 QGPLPMLQAQPGASATLANFPRGSTRSRMAP---SGEPGPSSLEPRGPPRERRAPA 784
Cdd:pfam03154  486 SSAMPGIQPPSSASVSSSGPVPAAVSCPLPPvqiKEEALDEAEEPESPPPPPRSPS 541
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
522-721 2.22e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 55.43  E-value: 2.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   522 VLPAQLSIPIPVPQAAAQSAPRTVHCPPI-----IWQAPKGQAPVPQELPVPQELPVPQELPVPQEVPVPQEIPVPQEIP 596
Cdd:pfam09770  165 VAPKKAAAPAPAPQPAAQPASLPAPSRKMmsleeVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQ 244
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   597 VPQELPVPQELPVPQELPvPQELPVPQELPVPQelPVPQELPVPQELPVPLEFQEVQQAQAVgwRAPKVPPHFWQPVSAQ 676
Cdd:pfam09770  245 QPQQQPQQPQQHPGQGHP-VTILQRPQSPQPDP--AQPSIQPQAQQFHQQPPPVPVQPTQIL--QNPNRLSAARVGYPQN 319
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 928505948   677 EAQEQATQIAHVEQQQPfqgapaSSKALQTQLPTHQAQASGLQAE 721
Cdd:pfam09770  320 PQPGVQPAPAHQAHRQQ------GSFGRQAPIITHPQQLAQLSEE 358
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
232-682 5.42e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 54.22  E-value: 5.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  232 GTPIAQQPTPGVLMAQQLTPGVLMVQPPAPGAPMVQPPPQAALMTQPAPSITPMAKPPGPGVVMIHPPGARGPIIQTPVS 311
Cdd:PRK07764  391 AGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAP 470
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  312 GAPMAQTVLPPGQPLATWAPQGQPlilqiqsqvirAPPQVPSVPQAPQvqlatppgwQATTPNwqvtpQGWPAT-PLTWQ 390
Cdd:PRK07764  471 AAAPEPTAAPAPAPPAAPAPAAAP-----------AAPAAPAAPAGAD---------DAATLR-----ERWPEIlAAVPK 525
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  391 ATQVTWQAPTIAWQATQPGRQ----GHSTIRTGHTPIRPGPAPLLRQippmirqiqpVMRQAPPLIRQVPIRPAPHGIAS 466
Cdd:PRK07764  526 RSRKTWAILLPEATVLGVRGDtlvlGFSTGGLARRFASPGNAEVLVT----------ALAEELGGDWQVEAVVGPAPGAA 595
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  467 QPqlWQVLPPPPPLRQAPQARLLLPRVPGTGQVSTVPPVAQIHlVPQSGPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVH 546
Cdd:PRK07764  596 GG--EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAP-AEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAK 672
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  547 CPPiiwQAPKGQAPVPQELPVPQELPVPQELPVPQEVPVPQEIPVPQEIPVPQELPVPQELPVPQELPVPQELPVPQELP 626
Cdd:PRK07764  673 AGG---AAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPP 749
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 928505948  627 VPQELP--VPQELPVPQELPVPLEFQEVQQAQAVGWRAPKVPPhfWQPVSAQEAQEQA 682
Cdd:PRK07764  750 DPAGAPaqPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPS--MDDEDRRDAEEVA 805
PHA03247 PHA03247
large tegument protein UL36; Provisional
11-293 1.10e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   11 SSPPESPVPAVHSRPTVLMRAPPASSRAPPVPWDPPPVDlQAPMAAWQAPQPAWEAPEGQLPAPVAQLAQPPGLGAPMVQ 90
Cdd:PHA03247 2769 PAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   91 AP-PLGGGMAkpptPGVLMVHQPPPGAPMAQSSTPGvlmlHPSVTGAPLAHPPPPGTPMTHPPgtsmahPPPPPPPPPPP 169
Cdd:PHA03247 2848 PSlPLGGSVA----PGGDVRRRPPSRSPAAKPAAPA----RPPVRRLARPAVSRSTESFALPP------DQPERPPQPQA 2913
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  170 PppgtpmthppppgtpmghhPPPGNPMTHPPPGNPMVHPLTHGAPmvhggphgtPMPHVPITGTPIAQQPTPGVlmaqqL 249
Cdd:PHA03247 2914 P-------------------PPPQPQPQPPPPPQPQPPPPPPPRP---------QPPLAPTTDPAGAGEPSGAV-----P 2960
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 928505948  250 TPGVLMVQPPAPGAPMVQPPPQAALMTQPAPSITPMAKPPGPGV 293
Cdd:PHA03247 2961 QPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRV 3004
PHA03247 PHA03247
large tegument protein UL36; Provisional
512-931 1.27e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 1.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  512 PQSGPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPiiwqAPKGQAPVPQELPVPQELPVPqELPVPQEVPVPQEIPV 591
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP----PPPSPSPAANEPDPHPPPTVP-PPERPRDDPAPGRVSR 2663
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  592 PQEIPVPQELPVPQElpvPQELPVPQELPVP-------QELPVPQELPVPQELPVPQELPVPLEFQEVQQAQAVGWRAPK 664
Cdd:PHA03247 2664 PRRARRLGRAAQASS---PPQRPRRRAARPTvgsltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPA 2740
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  665 VPPHFWQPVSAQEAQEQATQIAhveQQQPFQGAPASSKALQTQLPTHQAQASGLQAELPSVQLQPSWQGP----LPMLQA 740
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPT---TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPpaavLAPAAA 2817
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  741 QPGASATLANFPRGSTRSRMAPSGEPGPssLEPRGPPRERRAPARD--KKGPPKERMFIGATFCAPRGASASRAYVPTAW 818
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAQPTAPPPPPGP--PPPSLPLGGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  819 KNLPatsetFPATSRVFPSTSHFQPASSNAFRGPSAASESPKSLPFALQDPYACVEALPAVPWVPYPDGNASSACKSVPA 898
Cdd:PHA03247 2896 ESFA-----LPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPG 2970
                         410       420       430
                  ....*....|....*....|....*....|...
gi 928505948  899 ILMVAAAAPQASATAAEASKSSEPPRRPGKATR 931
Cdd:PHA03247 2971 RVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
PHA03247 PHA03247
large tegument protein UL36; Provisional
524-883 1.68e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  524 PAQLSIPIPVPQAAAQSAPrtvhcppiiwqaPKGQAPVPQELPVPQELPVPQELPVPQEVPVPQEIPVPQEIPVPQELPV 603
Cdd:PHA03247 2551 PPPPLPPAAPPAAPDRSVP------------PPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLP 2618
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  604 PQELPVPQelPVPQELPVPQELPVPQELPVPqELPVPQELPVPLEFQEVQQAQAVGWRA-PKVPPHFWQPVSAQEAQEQA 682
Cdd:PHA03247 2619 PDTHAPDP--PPPSPSPAANEPDPHPPPTVP-PPERPRDDPAPGRVSRPRRARRLGRAAqASSPPQRPRRRAARPTVGSL 2695
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  683 TQIAHVEQQQPFQGAPASSKALQTQLPTHQAQASGLQAELPSVQLQPswqgPLPMLQAQPGASATLANFPRGSTRSRMAP 762
Cdd:PHA03247 2696 TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPP----AVPAGPATPGGPARPARPPTTAGPPAPAP 2771
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  763 SGEPgpsslePRGPPRERRAPARDKKGPPKErmfigaTFCAPRGASASRAYVPTAWKNLPATSEtfPATSRVFPSTShfQ 842
Cdd:PHA03247 2772 PAAP------AAGPPRRLTRPAVASLSESRE------SLPSPWDPADPPAAVLAPAAALPPAAS--PAGPLPPPTSA--Q 2835
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 928505948  843 PASSNAFRGPSAASESPKSL-----PFALQDPYACVEALPAVPWVP 883
Cdd:PHA03247 2836 PTAPPPPPGPPPPSLPLGGSvapggDVRRRPPSRSPAAKPAAPARP 2881
rne PRK10811
ribonuclease E; Reviewed
528-734 4.28e-06

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 51.19  E-value: 4.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  528 SIPIPVPQAAAQSAPRtvhcppiiwqapkgQAPVPQELPVPQELPVPQELPVPQEVPVPQEIPVPQEIPVPQELPVPQE- 606
Cdd:PRK10811  844 RYPVVRPQDVQVEEQR--------------EAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEv 909
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  607 LPVPQELPVPQELPVPQELPV--PQELPVPQELPVPQE--LPVPLEFQEVQQAQAVGwRAPKVPPhfwQPVSAQEAQEQA 682
Cdd:PRK10811  910 VVVETTHPEVIAAPVTEQPQVitESDVAVAQEVAEHAEpvVEPQDETADIEEAAETA-EVVVAEP---EVVAQPAAPVVA 985
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 928505948  683 TQIAHVEQQQPFQGAPASSKALQTQLPTHQAQASGLQAELPSVQLQPS----WQGP 734
Cdd:PRK10811  986 EVAAEVETVTAVEPEVAPAQVPEATVEHNHATAPMTRAPAPEYVPEAPrhsdWQRP 1041
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
405-663 4.48e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 51.03  E-value: 4.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  405 ATQPGRQGhstirTGHTPIRPGPAPLLRQIPPmiRQIQPVMRQAPPLIRQVPIRPAPHGIASQPQLWQVLPPPPPLRQAP 484
Cdd:PRK12323  362 AFRPGQSG-----GGAGPATAAAAPVAQPAPA--AAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALA 434
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  485 QARLLLPRVPGTGQVSTVPPVAQIhlVPQSGPQVPQTVLPAQLSIPIPVPQA-AAQSAPRTVHCPPIIWQAPKGQAPVPQ 563
Cdd:PRK12323  435 AARQASARGPGGAPAPAPAPAAAP--AAAARPAAAGPRPVAAAAAAAPARAApAAAPAPADDDPPPWEELPPEFASPAPA 512
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  564 ELPVPQELPVPQELPVPQEVPVPQEIPVPQEIPVPQELPVPQELPVPQELPVPQELPVPQELPV-PQELPV-PQELPV-- 639
Cdd:PRK12323  513 QPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMfDGDWPAlAARLPVrg 592
                         250       260
                  ....*....|....*....|....*
gi 928505948  640 -PQELPVPLEFQEVQQAqAVGWRAP 663
Cdd:PRK12323  593 lAQQLARQSELAGVEGD-TVRLRVP 616
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
486-892 8.15e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.37  E-value: 8.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  486 ARLLLPRVPGT--GQVSTVPPVAQiHLVPQSGPQVPQTVLPAQlsipipvPQAAAQSAPrtvhcPPIIWQAPKGQAPVPQ 563
Cdd:PRK07764  360 ARMLLPSASDDerGLLARLERLER-RLGVAGGAGAPAAAAPSA-------AAAAPAAAP-----APAAAAPAAAAAPAPA 426
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  564 elPVPQELPVPQELPVPQEVPVPQEIPVPQEiPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQEL 643
Cdd:PRK07764  427 --AAPQPAPAPAPAPAPPSPAGNAPAGGAPS-PPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAP 503
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  644 PVPLEFQEVQQA-----QAVGWRAPKVPPHFWQPVSAQEAQEQATQIAHVEQ--QQPF---QGAPASSKALQTQL-PTHQ 712
Cdd:PRK07764  504 AGADDAATLRERwpeilAAVPKRSRKTWAILLPEATVLGVRGDTLVLGFSTGglARRFaspGNAEVLVTALAEELgGDWQ 583
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  713 AQA------SGLQAELPSVQLQPSWQGPLPMLQAQPGASATLANFPRGSTRSRMAPSGEPGPSSLEPRGPPRERRAPARD 786
Cdd:PRK07764  584 VEAvvgpapGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDAS 663
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  787 KKGPPKERMFIGATFCAPRGASASRAYVPTAWKNLPATSETFPATSRVFPSTS----HFQPASSNAFRGPSAASESPK-S 861
Cdd:PRK07764  664 DGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDpaaqPPQAAQGASAPSPAADDPVPLpP 743
                         410       420       430
                  ....*....|....*....|....*....|.
gi 928505948  862 LPFALQDPYACVEALPAVPWVPYPDGNASSA 892
Cdd:PRK07764  744 EPDDPPDPAGAPAQPPPPPAPAPAAAPAAAP 774
rne PRK10811
ribonuclease E; Reviewed
504-711 2.33e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 48.88  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  504 PVAQihlvpqsgPQVPQTVlpAQLSIPIPVPQAAAQSAPRTVHCPPIIWQAPKGQAPVPQELPVPQELPVPqelpvPQEV 583
Cdd:PRK10811  846 PVVR--------PQDVQVE--EQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQP-----EEVV 910
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  584 PVPQEIPVPQEIPVPQELPVPQELPVPQELPVPQElPVPQELPVPQELPVPQELPVPQELPVPLEFQEVQQAQAVgwrAP 663
Cdd:PRK10811  911 VVETTHPEVIAAPVTEQPQVITESDVAVAQEVAEH-AEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVV---AE 986
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 928505948  664 KVPPHFWQPVSAQEAQEQATQIAHVEQQQ---PFQGAPASskALQTQLPTH 711
Cdd:PRK10811  987 VAAEVETVTAVEPEVAPAQVPEATVEHNHataPMTRAPAP--EYVPEAPRH 1035
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
9-220 2.70e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 48.72  E-value: 2.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948    9 GDSSPPeSPVPAVHSRPTVLMRAPPASSRAPPVPWDPPPvdlQAPMAAWQAPQPAwEAPEGQLPAPVAQlaqppglgAPM 88
Cdd:PRK12323  370 GGAGPA-TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPA---AAPAAAAAARAVA-AAPARRSPAPEAL--------AAA 436
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   89 VQAPPLGGGMAKPPTPGVLMVHQPPPGAPMAQSSTPGVLMLHPSVTGAPLAHPPPpgTPMTHPPGTSMAHPPPPPPPPPP 168
Cdd:PRK12323  437 RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP--ADDDPPPWEELPPEFASPAPAQP 514
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 928505948  169 PPPPGTPMTHPPPPGTPMGHhPPPGNPMTHPPPGNPMVHPLTHGAPMVHGGP 220
Cdd:PRK12323  515 DAAPAGWVAESIPDPATADP-DDAFETLAPAPAAAPAPRAAAATEPVVAPRP 565
PRK10263 PRK10263
DNA translocase FtsK; Provisional
421-646 3.46e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 48.54  E-value: 3.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  421 TPIRPGPAPLLRQiPPMIRQIQPVMRQAPPLIRqvpirPAPHGIASQPQLWQVLPPPPPLRQAPQARLLLPRVPGTGQVS 500
Cdd:PRK10263  343 TPPVASVDVPPAQ-PTVAWQPVPGPQTGEPVIA-----PAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPA 416
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  501 TVPPVAQIHLVPQSGPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPIIWQAPKGQAPVPQELPVPQELPVPQELPVP 580
Cdd:PRK10263  417 QQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVV 496
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 928505948  581 QEVPvPQEIPVPQEIPVPQELPVPQELPVPQELPVPQelPVPQELPVPQELPVPQELPVPQELPVP 646
Cdd:PRK10263  497 EETK-PARPPLYYFEEVEEKRAREREQLAAWYQPIPE--PVKEPEPIKSSLKAPSVAAVPPVEAAA 559
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
52-387 3.60e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.06  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   52 APMAAWQAPQPAWEAPEGQLPAPVAQLAQPPGLGAPMVQAPPLGGGMAKPPTPGVLMVHQPPPGAPMAQSSTPGVLMLHP 131
Cdd:PRK07764  400 SAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAA 479
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  132 SVTGAPLAHPPPPGTPMTHPPGTSMAHPPPPPPPPPPPPPPGTPMTHPPPPGTPMGHhpppgNPMTHPPPGNPMVhpLTH 211
Cdd:PRK07764  480 PAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERWPEILAAVPKRSRKTWAILLP-----EATVLGVRGDTLV--LGF 552
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  212 GAP-----------------MVHGGPHGTPMPHVPITGTPIAQQPTPGVLMAQQLTPGVLmVQPPAPGAPmVQPPPQAAL 274
Cdd:PRK07764  553 STGglarrfaspgnaevlvtALAEELGGDWQVEAVVGPAPGAAGGEGPPAPASSGPPEEA-ARPAAPAAP-AAPAAPAPA 630
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  275 MTQPAPSITPMAKPPGPGVVMIHPPGARGPIIQTPVSGAPMAQTVLPPGQPLATWAPQGQPlilQIQSQVIRAP-PQVPS 353
Cdd:PRK07764  631 GAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPA---APAGAAPAQPaPAPAA 707
                         330       340       350
                  ....*....|....*....|....*....|....
gi 928505948  354 VPQAPQVQLATPPGWQATTPNWQVTPQGWPATPL 387
Cdd:PRK07764  708 TPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL 741
PHA03378 PHA03378
EBNA-3B; Provisional
420-794 4.21e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 48.14  E-value: 4.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  420 HTPIRPGPAPLLRQIPPMIRQIQPVMRQAPPLIRQVP-IRPAPHGIASQPQLWQVLPPPPPLRQAPQARLLLPRVPGTGQ 498
Cdd:PHA03378  560 HDQLLPAPGLGPLQIQPLTSPTTSQLASSAPSYAQTPwPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQ 639
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  499 VSTVPPVA--------QIHLVPQSGPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPiiwqAPKGQAPVPQELPVPQE 570
Cdd:PHA03378  640 PITFNVLVfptphqppQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPP----RAPTPMRPPAAPPGRAQ 715
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  571 LPVPQELPVPQEVPVPQEIPVPQEIPVPQELPVPQELPVPQELPVPQELPVPQELP-VPQELPVPQELPVPQELPvplef 649
Cdd:PHA03378  716 RPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPgAPTPQPPPQAPPAPQQRP----- 790
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  650 qevqQAQAVGWRAPKVPPHFWQpVSAQEAQEQATQIAHVEQQQPFQGAPASSKALQTQLPTHQAQASGLQAELPSVQLQP 729
Cdd:PHA03378  791 ----RGAPTPQPPPQAGPTSMQ-LMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDK 865
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 928505948  730 SWQGPL---PMLQAQPGASATLANFPRGSTRSRMAPSGEPGPSSLEPRGPPRERRAPARDKKGPPKER 794
Cdd:PHA03378  866 IVQAPVfypPVLQPIQVMRQLGSVRAAAASTVTQAPTEYTGERRGVGPMHPTDIPPSKRAKTDAYVES 933
PRK10263 PRK10263
DNA translocase FtsK; Provisional
528-793 5.28e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.77  E-value: 5.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  528 SIPIPVPQAAAQSAPRTVHCPPIiwqapkgqAPVPQELPVPQELPVPQELPVP-QEVPVPQeIPVPQEIPVPQELPvpqe 606
Cdd:PRK10263  315 PITEPVAVAAAATTATQSWAAPV--------EPVTQTPPVASVDVPPAQPTVAwQPVPGPQ-TGEPVIAPAPEGYP---- 381
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  607 lpvpqelpvpqelPVPQELPVPQELPVPQELPVPQELPVPLEFQEVQQAQAVGWRAPKVPPHFWQPVSAQEAQEQATQIA 686
Cdd:PRK10263  382 -------------QQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQ 448
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  687 HVEQQQPFQGAPASskalQTQLPTHQAQASGLQAELPSVQLQPSWQGPLPMLQAQPGASATLANFP-----RGSTRSRMA 761
Cdd:PRK10263  449 AEEQQSTFAPQSTY----QTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPLYYFEeveekRAREREQLA 524
                         250       260       270
                  ....*....|....*....|....*....|..
gi 928505948  762 PSGEPGPSSLEPRGPPRERRAPARDKKGPPKE 793
Cdd:PRK10263  525 AWYQPIPEPVKEPEPIKSSLKAPSVAAVPPVE 556
PRK10263 PRK10263
DNA translocase FtsK; Provisional
499-785 5.79e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.77  E-value: 5.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  499 VSTVPPVAQIHLVPQS---------GPQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHcppiiWQAPKGQAPVPQELPVPQ 569
Cdd:PRK10263  340 VTQTPPVASVDVPPAQptvawqpvpGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP-----LQQPVQPQQPYYAPAAEQ 414
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  570 ELPVPQELPVP-QEVPVPQEIPVPQEIPVPQELPVPQELPVPQELPVPQ-ELPVPQelPVPQELPVPQELPVPQELPVPL 647
Cdd:PRK10263  415 PAQQPYYAPAPeQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQtEQTYQQ--PAAQEPLYQQPQPVEQQPVVEP 492
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  648 EfQEVQQAQavgwraPKVPP-HFWQPVSAQEAQEQATQIAHveqqqpFQGAPASSKALQTQLPTHQAQASGLQAELPSVQ 726
Cdd:PRK10263  493 E-PVVEETK------PARPPlYYFEEVEEKRAREREQLAAW------YQPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAA 559
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 928505948  727 LQPSWQGPLPMLQAQPGASATLAnfprgSTRSRMAPSGEPGPSSLEPRGP----PRERRAPAR 785
Cdd:PRK10263  560 AVSPLASGVKKATLATGAAATVA-----APVFSLANSGGPRPQVKEGIGPqlprPKRIRVPTR 617
PRK11633 PRK11633
cell division protein DedD; Provisional
506-623 5.86e-05

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 45.76  E-value: 5.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  506 AQIHLVPQSGP-QVPQTVLPAQLSIPIPVPQAAAQSAprtvhcppiiwQAPKGQAPVPQELPVPQELPVPQELPVPQEVP 584
Cdd:PRK11633   39 AAIPLVPKPGDrDEPDMMPAATQALPTQPPEGAAEAV-----------RAGDAAAPSLDPATVAPPNTPVEPEPAPVEPP 107
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 928505948  585 VPQEIPVPQEIPVPQELPVPQELPVPQELPVPQELPVPQ 623
Cdd:PRK11633  108 KPKPVEKPKPKPKPQQKVEAPPAPKPEPKPVVEEKAAPT 146
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
528-682 6.31e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 47.17  E-value: 6.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  528 SIPIPVPQAAAQSAPrtvhcPPIIWQAPKGQAPVPQELPVPQELPVPQELPVPQEVPVPQEIPVPQEIPVPQELPVPQEL 607
Cdd:PRK07994  362 AAPLPEPEVPPQSAA-----PAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGAT 436
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 928505948  608 PVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPLEfqevqqaqAVGWRAPKVPPHFWQPVSAQEAQEQA 682
Cdd:PRK07994  437 KAKKSEPAAASRARPVNSALERLASVRPAPSALEKAPAKKE--------AYRWKATNPVEVKKEPVATPKALKKA 503
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
516-648 1.17e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 46.40  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  516 PQVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPIIWQAPKGQAPVPQELPVPQELPVPQELPVPQEVPVPQEI-PVPQE 594
Cdd:PRK07994  368 PEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSePAAAS 447
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 928505948  595 IPVPQELPVPQELPVPQELPVPQELPVPQEL----PVPQELPVPQELPVPQELPVPLE 648
Cdd:PRK07994  448 RARPVNSALERLASVRPAPSALEKAPAKKEAyrwkATNPVEVKKEPVATPKALKKALE 505
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
451-723 1.61e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  451 LIRQVPIRPAPHGIASQpqlwqvlppppplrqapqarlllPRVPGTGQVSTVPPVAqihlvpqsgpQVPQTVLPAQLSIP 530
Cdd:PRK12323  357 LLRMLAFRPGQSGGGAG-----------------------PATAAAAPVAQPAPAA----------AAPAAAAPAPAAPP 403
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  531 IPVPQAAAQSAPrtvhcPPIIWQAPKGQAPVPQELPVPQELPVPQELPVPQEVPVPQEIPVPQEIPvpqelPVPQELPVP 610
Cdd:PRK12323  404 AAPAAAPAAAAA-----ARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARP-----AAAGPRPVA 473
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  611 QELPVPQELPVPQELPVPQELPVPQELPVPQELPVPLEFQevQQAQAVGWRAPKVP-PHFWQPVSAQEAQEQATQIAHVE 689
Cdd:PRK12323  474 AAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQ--PDAAPAGWVAESIPdPATADPDDAFETLAPAPAAAPAP 551
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 928505948  690 ----QQQPFQGAPASSKALQTQLPTHQAQASGLQAELP 723
Cdd:PRK12323  552 raaaATEPVVAPRPPRASASGLPDMFDGDWPALAARLP 589
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
11-206 2.81e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   11 SSPPESPVPAVHSRPTVLMRAPPASSRAPPVPWDPPPVDLQAPMAAWQAPQPAWEAPEGQLPAPVAQLAQPPGLGAPMVQ 90
Cdd:PRK07764  594 AAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKA 673
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   91 APPLGGGMAKPPTPGVlmvHQPPPGAPMAQSSTPGVLMLHPSVTGAPLAHPPPPGTPMTHPPGTSMAHPPPPPPPPPPPP 170
Cdd:PRK07764  674 GGAAPAAPPPAPAPAA---PAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPD 750
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 928505948  171 PPGTPMTHPPPPGTPMGHHPPPGNPMTHPPPGNPMV 206
Cdd:PRK07764  751 PAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMA 786
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
3-399 5.04e-04

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 44.61  E-value: 5.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948     3 QLSTNLGDSSPPESPVPAVHSRPTVLMRAPPASSRAPPVPWDPPPVDLQAPMAAWQAPQPAWEAPEGQLPAPVAQLAQPP 82
Cdd:pfam09606   87 QNLAGQGTRPQMMGPMGPGPGGPMGQQMGGPGTASNLLASLGRPQMPMGGAGFPSQMSRVGRMQPGGQAGGMMQPSSGQP 166
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948    83 GLGAPmvQAPPLGGGMAKPPTPGVLMVHQPPPGAPMaqsstpgvlmlhPSVTGAPLahPPPPGTPMTHPPGTSMAHPPPP 162
Cdd:pfam09606  167 GSGTP--NQMGPNGGPGQGQAGGMNGGQQGPMGGQM------------PPQMGVPG--MPGPADAGAQMGQQAQANGGMN 230
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   163 PPPPPPPPPPGTPMTHPPPPGTPMGHHPPPGNPMTHPPPGNPMVHPltHGAPMVHGGPHGtpmphvpitgtpiaQQPtpg 242
Cdd:pfam09606  231 PQQMGGAPNQVAMQQQQPQQQGQQSQLGMGINQMQQMPQGVGGGAG--QGGPGQPMGPPG--------------QQP--- 291
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   243 vlmaQQLTPGVLMVQPPAPGAPMVQPPPQAALMTQPAPSITPMAKPPGPGVVMIHPPGARGPIIQTPVSGAPMAQTVLPP 322
Cdd:pfam09606  292 ----GAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANPMQR 367
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 928505948   323 GQPLATwaPQGQPLILQIQSQVirAPPQVPSVPQAPQVQLATPPGWQattPNWQVTPQGWPATPLTWQATQVTWQAP 399
Cdd:pfam09606  368 GQPGMM--SSPSPVPGQQVRQV--TPNQFMRQSPQPSVPSPQGPGSQ---PPQSHPGGMIPSPALIPSPSPQMSQQP 437
PHA03247 PHA03247
large tegument protein UL36; Provisional
230-793 5.22e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 5.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  230 ITGTPIAQQPTPGVLMAQQLTP-GVLMVQPPAPGAPMVQPPPQAALMTQPAPSitpmakppgPGVVMIHPPGARG-PIIQ 307
Cdd:PHA03247 2386 IAARPLARSPPCLVLVDISMAPlFVLWEQPDPPGPPDVRFVGSEEIEELPFVS---------PGGDVLAGLAADGdPFFA 2456
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  308 TPVSGAPMAQTVLP----PGQPLATWAPQGQ-PLILQIQSQVIRAPPQVPSVPQAPQVQlaTPPGWQATTPNWQVTPQGW 382
Cdd:PHA03247 2457 RTILGAPFSLSLLLgelfPGAPVYRRPAEARfPFAAGAAPDPGGGGPPDPDAPPAPSRL--APAILPDEPVGEPVHPRML 2534
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  383 P-ATPLTWQATQVTWQAPTIAWQATQPGRQGHSTIRTGHTPIRPGPAPLLRQIPPMIRQiQPVMRQAPPLIRQVPIRPAP 461
Cdd:PHA03247 2535 TwIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPP-QSARPRAPVDDRGDPRGPAP 2613
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  462 HGIAsqpqlwqvLPPPPPLRQAPQARLLLPRVPGTGQVSTVPPVAQihlvPQSGPQVPQTVLPAQLSIPIPVPQAAA--Q 539
Cdd:PHA03247 2614 PSPL--------PPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPER----PRDDPAPGRVSRPRRARRLGRAAQASSppQ 2681
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  540 SAPRTVHCPPIIWQAPKGQAPVPQELPVPQELPVPQELPVPqevPVPQeiPVPQEIPVPQELPVPQELPVPQELPVPQEL 619
Cdd:PHA03247 2682 RPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLP---PGPA--AARQASPALPAAPAPPAVPAGPATPGGPAR 2756
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  620 PVPQELPVPQELPVPQELPV---PQELPVPLEFQEVQQAQAVGwrAPKVPPHFWQPVSAQEAQEQATQIAHVEQQQPFQG 696
Cdd:PHA03247 2757 PARPPTTAGPPAPAPPAAPAagpPRRLTRPAVASLSESRESLP--SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSA 2834
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  697 APASSKALQTQLPTHQAQASGLQAELPSVQLQPSWQGPlpmlqAQPGASATlanfPRGSTRSRMAPSGEPGPSSLEPRGP 776
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPA-----AKPAAPAR----PPVRRLARPAVSRSTESFALPPDQP 2905
                         570
                  ....*....|....*..
gi 928505948  777 PRERRAPARDKKGPPKE 793
Cdd:PHA03247 2906 ERPPQPQAPPPPQPQPQ 2922
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
465-777 6.39e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 6.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   465 ASQPQLWQVLPPPPPLRQAPQARLLLPRVPGTGQVSTVPPVAQIHLVPQSGPQVPQtvlPAQLSIPIPVPQAAAQSAPrT 544
Cdd:pfam03154  161 SAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQ---PPNQTQSTAAPHTLIQQTP-T 236
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   545 VHCPPIIWQAPKGQaPVPQELPVPQELPVPQELPVPQEVPVPQEIPVPQEIPVPQELPVPQELPVPQELPVPQELPVPQE 624
Cdd:pfam03154  237 LHPQRLPSPHPPLQ-PMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSP 315
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   625 lPVPQELPVPQELPVPQELPVPLEFQEVQQAQAVGWRAPKVPPHFWQPVSAQEAQEQATQIAHVEQQQPFQG----APAS 700
Cdd:pfam03154  316 -AAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMnsnlPPPP 394
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   701 SKALQTQLPTHQ---AQASGLQAELPSVQLQPSWQGPlPMLQAQPGASATLANFPRGSTRSRMAPSGEPGPSSLEPRGPP 777
Cdd:pfam03154  395 ALKPLSSLSTHHppsAHPPPLQLMPQSQQLPPPPAQP-PVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPP 473
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
526-647 8.57e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 43.64  E-value: 8.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   526 QLSIPIPVPQAAAQSAPRTVH------CPPIIWQA----PKGQAPVPQELPVPQELPVPQELPVPQEVPVPQEIPVP--Q 593
Cdd:TIGR01628  384 QLPMGSPMGGAMGQPPYYGQGpqqqfnGQPLGWPRmsmmPTPMGPGGPLRPNGLAPMNAVRAPSRNAQNAAQKPPMQpvM 463
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 928505948   594 EIPVPQELPVPQELPVPQELPVpQELPVPQELPVPQELPVPQELPVPQELPVPL 647
Cdd:TIGR01628  464 YPPNYQSLPLSQDLPQPQSTAS-QGGQNKKLAQVLASATPQMQKQVLGERLFPL 516
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
92-291 1.14e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   92 PPLGGGMAKPPTPGVLMVHQPPPG--APMAQSSTPGVLMLHPSVTGAPLAHPPPPG---TPMTHPPGTSMAHPPPPPPPP 166
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVAQPAPAaaAPAAAAPAPAAPPAAPAAAPAAAAAARAVAaapARRSPAPEALAAARQASARGP 444
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  167 PPPPPPGTPMTHPPPPGTPMGHHPPPGNPMTHPPPgNPMVHPLTHGAPMVHGGPHGTPMPHVPITGTPIAQQPTP-GVLM 245
Cdd:PRK12323  445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAA-PARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPaGWVA 523
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 928505948  246 AQQLTPGvlmVQPPAPGAPMVQPPPQAALMTQPAPSITPMAKPPGP 291
Cdd:PRK12323  524 ESIPDPA---TADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPP 566
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
1-131 1.65e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.84  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948    1 MSQLSTNLGDSSPPESPVPAVHSRPTVLMRAPPASSRAPPVPWDPPPVDLQAPMAAWQAPQPAWEAPEGQLPAPVAQLAQ 80
Cdd:PRK14971  359 LAQLTQKGDDASGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVN 438
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 928505948   81 PPGLGAPMVqapplgggmakppTPGVLMVHQPPPgaPMAQSSTpGVLMLHP 131
Cdd:PRK14971  439 PPSTAPQAV-------------RPAQFKEEKKIP--VSKVSSL-GPSTLRP 473
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
72-461 1.89e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   72 PAPVAQLAQPPGLGAPMVQAPPLGGGMAKPPTPGVLMVHQPPPGAPMAQSStpgvlmlHPSVTGAPLAHPPPPGTPMTHP 151
Cdd:PRK07764  390 GAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPA-------PPSPAGNAPAGGAPSPPPAAAP 462
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  152 PGTSMAHPPPPPPPPPPPPPPGTPMTHPPPPGTPMGHHPPPGNPMTHPPP-------------GNPMVHPLTHGAPMVHG 218
Cdd:PRK07764  463 SAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLrerwpeilaavpkRSRKTWAILLPEATVLG 542
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  219 --GPHGTPMPHVPITGTPIAQQPTPGVLM---AQQL--TPGVLMVQPPAPGA----------PMVQPPPQAALMTQPAPS 281
Cdd:PRK07764  543 vrGDTLVLGFSTGGLARRFASPGNAEVLVtalAEELggDWQVEAVVGPAPGAaggegppapaSSGPPEEAARPAAPAAPA 622
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  282 ITPMAKPPGPgvvmihPPGARGPIIQTPVSGAPMAQTVLPPGQPLATWAPQGQPLILQIQSQVIRAPPQVPSVPQAPQVQ 361
Cdd:PRK07764  623 APAAPAPAGA------AAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGA 696
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  362 latPPGWQATTPNWQVTPQGWPATPLTWQAtqvtwqaptiawQATQPGRQGHSTIRTGHTPIRPGPAPLLRQIPPMIRQI 441
Cdd:PRK07764  697 ---APAQPAPAPAATPPAGQADDPAAQPPQ------------AAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPP 761
                         410       420
                  ....*....|....*....|
gi 928505948  442 QPVMRQAPPLIRQVPIRPAP 461
Cdd:PRK07764  762 PAPAPAAAPAAAPPPSPPSE 781
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
223-354 2.95e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 41.72  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  223 TPMPhVPITGTPIAQQPTPgvlmaQQLTPGVLMVQPPAPGAPMVQPPPQAALMTQPAPSITPMAKPPGPgvvmIHPPGAR 302
Cdd:PRK14950  361 VPVP-APQPAKPTAAAPSP-----VRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPH----TPESAPK 430
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 928505948  303 GPIIQTPVSGAPMAQtvlPPGQPLATWAPQGQPLILQIQSQVI------RAPPQVPSV 354
Cdd:PRK14950  431 LTRAAIPVDEKPKYT---PPAPPKEEEKALIADGDVLEQLEAIwkqilrDVPPRSPAV 485
PRK10263 PRK10263
DNA translocase FtsK; Provisional
602-850 3.34e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.99  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  602 PVPQELPVPQELPVPQElPVPQELPVP-QELPVPQELPVPQELPVPLEFQEVQQAQAVGWRAPKVP-PHFWQPVSAQEAQ 679
Cdd:PRK10263  339 PVTQTPPVASVDVPPAQ-PTVAWQPVPgPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPqQPYYAPAAEQPAQ 417
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  680 EQATQIAHVEQQQPFQGAPASSKALQTQLPTHQAQASGLQAElPSVQLQPSWQGPL---PMLQAQPGASATLANFPrgst 756
Cdd:PRK10263  418 QPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQ-STYQTEQTYQQPAaqePLYQQPQPVEQQPVVEP---- 492
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  757 rsrmapsgEPGPSSLEPRGPP-------RERRAPARDKKG--------PPKERMFIGATFCAPRGASASRAYVPTAWKNL 821
Cdd:PRK10263  493 --------EPVVEETKPARPPlyyfeevEEKRAREREQLAawyqpipePVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPL 564
                         250       260       270
                  ....*....|....*....|....*....|.
gi 928505948  822 PA--TSETFPATSRVFPSTSHFQPASSNAFR 850
Cdd:PRK10263  565 ASgvKKATLATGAAATVAAPVFSLANSGGPR 595
PHA03378 PHA03378
EBNA-3B; Provisional
14-372 4.08e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.59  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   14 PESPVPAV--HSRPTVLMRAP--PASSRAPPVPWDPPPVDLQAPMAAWQAPQPAWEAPEGQL------------------ 71
Cdd:PHA03378  445 PHSQAPTVvlHRPPTQPLEGPtgPLSVQAPLEPWQPLPHPQVTPVILHQPPAQGVQAHGSMLdllekddedmeqrvmatl 524
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   72 --PAPVAQLAqppGLGAPMVQAPPLGGGMAKP-PTPGVLMVHQPPPG------APMAQSSTPGVLMLHPSVTGAPLAHPP 142
Cdd:PHA03378  525 lpPSPPQPRA---GRRAPCVYTEDLDIESDEPaSTEPVHDQLLPAPGlgplqiQPLTSPTTSQLASSAPSYAQTPWPVPH 601
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  143 PPGTP-----MTHPPGTSmahpppppppppppPPPGTPMTHPPPPGTPMGHHPPPGNPMTHPPPGNPMVHPLTHGAPMVH 217
Cdd:PHA03378  602 PSQTPeppttQSHIPETS--------------APRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWT 667
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  218 GGPHGTPMPHVPITGTPIAQQPTPGVLMAQQLTPGVLmvqPPAPGAPMVQPPPQAALMTQPAPSITPMAKPPGPGVVMIH 297
Cdd:PHA03378  668 QIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPM---RPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRA 744
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 928505948  298 PPGARGPIIQTPVSGAP--MAQTVLPPGQPLATWAPQGQPLILQiQSQVIRAPPQVPSVPQAP-QVQLATPPGWQATT 372
Cdd:PHA03378  745 RPPAAAPGRARPPAAAPgrARPPAAAPGAPTPQPPPQAPPAPQQ-RPRGAPTPQPPPQAGPTSmQLMPRAAPGQQGPT 821
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
522-664 4.10e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.49  E-value: 4.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  522 VLPAQLSIPIPVPQAAAQSAPRTV---------HCPPIIWQAPKGQAPVPQE----LPVPQELPVPQELPVPQEVPVPqe 588
Cdd:PTZ00441  284 VEPEPLPVPAPVPPTPEDDNPRPTddefavpnfNEGLDVPDNPQDPVPPPNEgkdgNPNEENLFPPGDDEVPDESNVP-- 361
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 928505948  589 iPVPQEIPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPVPLEFQEVQQAQAVGWRAPK 664
Cdd:PTZ00441  362 -PNPPNVPGGSNSEFSSDVENPPNPPNPDIPEQEPNIPEDSNKEVPEDVPMEPEDDRDNNFNEPKKPENKGDGQNE 436
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
127-404 4.45e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 4.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  127 LMLHPSVTGAPLAHPPPPGTPMTHPPGTSMAHPPPPPPPPPPPPPPGTPMTHPpppgtpmghhPPPGNPMTHPPPGNPMV 206
Cdd:PRK12323  361 LAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAA----------AAARAVAAAPARRSPAP 430
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  207 HPLTHGAPMVHGGPHGTPMPHVPITGTPIAQQPTPgvlmaqqltpgvlMVQPPAPGAPMVQPPPQAALMTQPAPSitPMA 286
Cdd:PRK12323  431 EALAAARQASARGPGGAPAPAPAPAAAPAAAARPA-------------AAGPRPVAAAAAAAPARAAPAAAPAPA--DDD 495
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  287 KPPG---PGVVMIHPPGARGPIIQTPVSGAPMAQTVLPPGQPLATWAPQgqplilqiqsqviRAPPQVPSVPQAPQVQLA 363
Cdd:PRK12323  496 PPPWeelPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPA-------------PAAAPAPRAAAATEPVVA 562
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 928505948  364 TPPGWQATTPNWQVTPQGWPA----TPLTWQATQVTWQAPTIAWQ 404
Cdd:PRK12323  563 PRPPRASASGLPDMFDGDWPAlaarLPVRGLAQQLARQSELAGVE 607
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
70-374 5.26e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 5.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948    70 QLPAPVAQLAQPPGLGAPMVQAPPLGGGMAKPPTPGVLMVHQPPPGAPMAQSSTPGVLMLHPSVTGAPLAHPPPPGTPmt 149
Cdd:pfam03154  168 QTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSP-- 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   150 HPPGTSMAHPPPPPPppppppppgtpmthppppgTPMGHHPPPgnpmTHPPPGNPMVHPLTHGAPMVhggPHGTPMPHVP 229
Cdd:pfam03154  246 HPPLQPMTQPPPPSQ-------------------VSPQPLPQP----SLHGQMPPMPHSLQTGPSHM---QHPVPPQPFP 299
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   230 ITGTPIAQQPTPGVLMAQQLTPGVLMVQPPAPGAPMVQPPPQAALMTqPAPSITPMAKPPGPGVV--------MIHPPGA 301
Cdd:pfam03154  300 LTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLP-PAPLSMPHIKPPPTTPIpqlpnpqsHKHPPHL 378
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 928505948   302 RGPIIQTPVSGAPMAQTVLPPGQPLATWAPQGQPLILQIQSQVIRAPPQVPSVPQAPQVQLATPPGWQATTPN 374
Cdd:pfam03154  379 SGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTS 451
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
491-667 5.51e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.99  E-value: 5.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  491 PRVPGTGQVSTVPPVAQIHLVPQSGPqVPQTVLPAQLSIPIPVPQAAAQSAPRTVHCPPIiwQAPKGQAPVPQELPVPQE 570
Cdd:PRK07003  360 PAVTGGGAPGGGVPARVAGAVPAPGA-RAAAAVGASAVPAVTAVTGAAGAALAPKAAAAA--AATRAEAPPAAPAPPATA 436
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  571 LPVPQELPVPQEVPVPQEIPVPQEIPVPQELPVPQELPVPQELPVP-QELPVPQELPVPQELPVPQELPVPQELPVPLEF 649
Cdd:PRK07003  437 DRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASdAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAA 516
                         170
                  ....*....|....*...
gi 928505948  650 QEVQQAQAVGWRAPKVPP 667
Cdd:PRK07003  517 SREDAPAAAAPPAPEARP 534
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
554-693 6.50e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.91  E-value: 6.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  554 APKGQAPVPQELPVPQElPVPQELPVPQEVPVPQeipvPQEIPVPQELPVPQELPVPQELPVPQELPVPQELPVPQELPV 633
Cdd:PRK14971  369 ASGGRGPKQHIKPVFTQ-PAAAPQPSAAAAASPS----PSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTA 443
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 928505948  634 PQELPVPQ---ELPVPLEfqevqqaqavgwRAPKVPPHFWQPVsaQEAQEQATQIAHVEQQQP 693
Cdd:PRK14971  444 PQAVRPAQfkeEKKIPVS------------KVSSLGPSTLRPI--QEKAEQATGNIKEAPTGT 492
PHA03379 PHA03379
EBNA-3A; Provisional
346-707 8.70e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 40.43  E-value: 8.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  346 RAPPQVPSvPQAPQVQLATPPGWQATTPN---WQVTPQGwPATPLTWQATQVTWQAPTIAWQATQPGRQGHSTIRTGhtp 422
Cdd:PHA03379  417 RPPVEKPR-PEVPQSLETATSHGSAQVPEpppVHDLEPG-PLHDQHSMAPCPVAQLPPGPLQDLEPGDQLPGVVQDG--- 491
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  423 iRPGPAPLLRQIPPMIRQIQPVMRQAPPlIRQVPIRPAPHGIASQPQlwQVLPPPPPLRQAPQARLLlprvPGTGQVSTV 502
Cdd:PHA03379  492 -RPACAPVPAPAGPIVRPWEASLSQVPG-VAFAPVMPQPMPVEPVPV--PTVALERPVCPAPPLIAM----QGPGETSGI 563
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  503 PPVAQIHLVPQSGPQVPQTvlPAQLSIPIPVPQAAAQSAPRTVHC---PPIIWQAPKGQapvPQELPVPQELPVPQELPV 579
Cdd:PHA03379  564 VRVRERWRPAPWTPNPPRS--PSQMSVRDRLARLRAEAQPYQASVevqPPQLTQVSPQQ---PMEYPLEPEQQMFPGSPF 638
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  580 PQEVPVPQEIPVPQEIPVPQELPVPQelPVPQELPVP----QELPVPqelPVPQELPVPQELPVPQELPVPLE-FQEVQQ 654
Cdd:PHA03379  639 SQVADVMRAGGVPAMQPQYFDLPLQQ--PISQGAPLAplraSMGPVP---PVPATQPQYFDIPLTEPINQGASaAHFLPQ 713
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  655 AQAVGwraPKVPPHFW-------QPVSAQEAQEQ------ATQIAH-----------------VEQQQPFQGAPASSKAL 704
Cdd:PHA03379  714 QPMEG---PLVPERWMfqgatlsQSVRPGVAQSQyfdlplTQPINHgapaahflhqppmegpwVPEQWMFQGAPPSQGTD 790

                  ...
gi 928505948  705 QTQ 707
Cdd:PHA03379  791 VVQ 793
PRK10819 PRK10819
transport protein TonB; Provisional
555-667 9.27e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 39.28  E-value: 9.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  555 PKGQAPVPQELPVPQELPVPQelpVPQEVPVPQEIPVPQEIPVPqELPVPQELPVPQELPVPQELPVPQELPVPQELPVP 634
Cdd:PRK10819   42 PAPAQPISVTMVAPADLEPPQ---AVQPPPEPVVEPEPEPEPIP-EPPKEAPVVIPKPEPKPKPKPKPKPKPVKKVEEQP 117
                          90       100       110
                  ....*....|....*....|....*....|...
gi 928505948  635 QELPVPQELPVPLEFQEVQQAQAVGWRAPKVPP 667
Cdd:PRK10819  118 KREVKPVEPRPASPFENTAPARPTSSTATAAAS 150
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
11-291 9.50e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 9.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   11 SSPPESPVPAVHSRPTVLMRAPPA----SSRAPPVPWDPPPVDLQAPMAAWQAPQP---AWEAPEGQLPAPVAQLAQPPG 83
Cdd:PRK07764  427 AAPQPAPAPAPAPAPPSPAGNAPAggapSPPPAAAPSAQPAPAPAAAPEPTAAPAPappAAPAPAAAPAAPAAPAAPAGA 506
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948   84 LGAPMVQ----------------------------------------APPLGGGMAKPPTPGVLM--------------- 108
Cdd:PRK07764  507 DDAATLRerwpeilaavpkrsrktwaillpeatvlgvrgdtlvlgfsTGGLARRFASPGNAEVLVtalaeelggdwqvea 586
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  109 VHQPPPGAPMAQSSTPGVLMLHPSVTGAPLAHPPPPGTPMTHPPGTSMAHPPPPPPPPPPPPPPGTPMTHPPPPGTPMGH 188
Cdd:PRK07764  587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGG 666
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928505948  189 HPPPGN-----PMTHPPPGNPMVHPLTHGAPMVHGGPHGTPMPHVPITGTPIAQQPTPGVlmAQQLTPGVLMVQPPAPGA 263
Cdd:PRK07764  667 DGWPAKaggaaPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQ--GASAPSPAADDPVPLPPE 744
                         330       340
                  ....*....|....*....|....*...
gi 928505948  264 PMVQPPPQAALMTQPAPSITPMAKPPGP 291
Cdd:PRK07764  745 PDDPPDPAGAPAQPPPPPAPAPAAAPAA 772
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH