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Conserved domains on  [gi|52001246|sp|Q8R040|]
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RecName: Full=Ribonuclease P protein subunit p21; Short=RNaseP protein p21; AltName: Full=Ribonucleoprotein V

Protein Classification

ribonuclease P Rpr2/Rpp21/SNM1 subunit( domain architecture ID 10513160)

ribonuclease P (RNAse P) Rpr2/Rpp21/SNM1 subunit is a component of RNAse P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends

EC:  3.1.26.5
Gene Ontology:  GO:0046872|GO:0004526|GO:0006278

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rpr2 pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of ...
 13-96 6.16e-25

RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologs. This family includes SNM1. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically. This subunit possibly binds the precursor tRNA.


:

Pssm-ID: 427665  Cd Length: 88  Bit Score: 91.20  E-value: 6.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52001246    13 RLSFLYQAAHCVlsQNPENQALARFYCHTEKTIAKRLVLRQDPSVKRTLCRSCSSLLIPGLTCT------QRQRRRKGQR 86
Cdd:pfam04032   1 RLNFLYQAAHLL--ARPGNPELSRRYVSLLRAISKKAVLRLPPSIKRTICKKCGTLLIPGVTCTvrienkSKGGKKPWAD 78

                          90
                  ....*....|
gi 52001246    87 WTVQTCLTCQ 96
Cdd:pfam04032  79 VLVYTCLTCG 88
 
Name Accession Description Interval E-value
Rpr2 pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of ...
 13-96 6.16e-25

RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologs. This family includes SNM1. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically. This subunit possibly binds the precursor tRNA.


Pssm-ID: 427665  Cd Length: 88  Bit Score: 91.20  E-value: 6.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52001246    13 RLSFLYQAAHCVlsQNPENQALARFYCHTEKTIAKRLVLRQDPSVKRTLCRSCSSLLIPGLTCT------QRQRRRKGQR 86
Cdd:pfam04032   1 RLNFLYQAAHLL--ARPGNPELSRRYVSLLRAISKKAVLRLPPSIKRTICKKCGTLLIPGVTCTvrienkSKGGKKPWAD 78

                          90
                  ....*....|
gi 52001246    87 WTVQTCLTCQ 96
Cdd:pfam04032  79 VLVYTCLTCG 88
RPR2 COG2023
Ribonuclease P protein subunit RPR2 [Translation, ribosomal structure and biogenesis];
10-76 4.90e-05

Ribonuclease P protein subunit RPR2 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441626  Cd Length: 90  Bit Score: 39.81  E-value: 4.90e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 52001246  10 AFQRLSFLYQAAH-CVLSQNPEnqaLARFYCHTEKTIAKRLVLRQDPSVKRTLCRSCSSLLIPGLTCT 76
Cdd:COG2023   2 ARERIEILFELAEeAAREGNPE---LARRYVELARRIAMKYRVRLPRELKRRFCKKCDAPLVPGVNAR 66
PRK03954 PRK03954
ribonuclease P protein component 4; Validated
 6-101 4.37e-04

ribonuclease P protein component 4; Validated


Pssm-ID: 235180  Cd Length: 121  Bit Score: 37.90  E-value: 4.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52001246    6 KDREAFQRLSFLYQAAHCVLSQNPEnqaLARFYCHTEKTIAKRLVLRQDPSVKRTLCRSCSSLLIPGLTCTQRQRRRKGQ 85
Cdd:PRK03954  14 KKRIARERIDTLFTLAERVFPYSPE---LANRYVELALAVQQKAKVKLPRKWKRRYCKRCHSFLVPGVNARVRLRQKRMP 90

                         90
                 ....*....|....*.
gi 52001246   86 RwTVQTCLTCQRSQRF 101
Cdd:PRK03954  91 H-VVITCLECGHIMRY 105
 
Name Accession Description Interval E-value
Rpr2 pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of ...
 13-96 6.16e-25

RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologs. This family includes SNM1. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically. This subunit possibly binds the precursor tRNA.


Pssm-ID: 427665  Cd Length: 88  Bit Score: 91.20  E-value: 6.16e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52001246    13 RLSFLYQAAHCVlsQNPENQALARFYCHTEKTIAKRLVLRQDPSVKRTLCRSCSSLLIPGLTCT------QRQRRRKGQR 86
Cdd:pfam04032   1 RLNFLYQAAHLL--ARPGNPELSRRYVSLLRAISKKAVLRLPPSIKRTICKKCGTLLIPGVTCTvrienkSKGGKKPWAD 78

                          90
                  ....*....|
gi 52001246    87 WTVQTCLTCQ 96
Cdd:pfam04032  79 VLVYTCLTCG 88
RPR2 COG2023
Ribonuclease P protein subunit RPR2 [Translation, ribosomal structure and biogenesis];
10-76 4.90e-05

Ribonuclease P protein subunit RPR2 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441626  Cd Length: 90  Bit Score: 39.81  E-value: 4.90e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 52001246  10 AFQRLSFLYQAAH-CVLSQNPEnqaLARFYCHTEKTIAKRLVLRQDPSVKRTLCRSCSSLLIPGLTCT 76
Cdd:COG2023   2 ARERIEILFELAEeAAREGNPE---LARRYVELARRIAMKYRVRLPRELKRRFCKKCDAPLVPGVNAR 66
PRK03954 PRK03954
ribonuclease P protein component 4; Validated
 6-101 4.37e-04

ribonuclease P protein component 4; Validated


Pssm-ID: 235180  Cd Length: 121  Bit Score: 37.90  E-value: 4.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52001246    6 KDREAFQRLSFLYQAAHCVLSQNPEnqaLARFYCHTEKTIAKRLVLRQDPSVKRTLCRSCSSLLIPGLTCTQRQRRRKGQ 85
Cdd:PRK03954  14 KKRIARERIDTLFTLAERVFPYSPE---LANRYVELALAVQQKAKVKLPRKWKRRYCKRCHSFLVPGVNARVRLRQKRMP 90

                         90
                 ....*....|....*.
gi 52001246   86 RwTVQTCLTCQRSQRF 101
Cdd:PRK03954  91 H-VVITCLECGHIMRY 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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