|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
12-479 |
0e+00 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 565.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 172 LIVGALALNILACGSLMRplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17428 161 LIVGALALNLLACGSLMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17428 179 ----------------------------------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARS 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 332 YHVREEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNWS 411
Cdd:cd17428 213 ENIIEEIALIPLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWS 292
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81885900 412 IFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17428 293 IFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLLA 360
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
12-479 |
4.96e-117 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 349.79 E-value: 4.96e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 172 LIVGALALNILACGSLMRPLQTSDCPFPEktapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEPPDNQARL--------------------------------------------------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 252 kslaiaahtkepetykkkvveqtnfckqlakrkwQLYRNYCGETASLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17314 190 ----------------------------------HVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRS 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 332 YHVREEDLTMPLISIFGIMTAVGKLLLGILADFKwINTLYLYVATLIITGLALCAIPFAKSY--VTLAILSGILGFLTGN 409
Cdd:cd17314 236 LQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFF-GGRLSTLSILLTILGLGLCAFLFLLKMtpVGLVLTGSLLGFSYGG 314
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81885900 410 WSIFPYVTTKTV-GIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17314 315 LFTVYPATVSTVfGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
12-479 |
8.12e-102 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 309.87 E-value: 8.12e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 172 LIVGALALNILACGSLMRplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17352 179 ----------------------------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKS 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 332 YHVrEEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNWS 411
Cdd:cd17352 213 LGI-DESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYS 291
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81885900 412 IFPYVT-TKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17352 292 SLTPVIlADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
12-478 |
7.77e-66 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 217.01 E-value: 7.77e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 172 LIVGALALNILACGSLMRplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17429 179 ----------------------------------------------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKL 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 332 YHVREEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNWS 411
Cdd:cd17429 213 YGLSEQNDKFPLTSIIAIVHIFGKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGYFS 292
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81885900 412 IFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17429 293 LMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICLLL 359
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
7-493 |
1.97e-58 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 199.97 E-value: 1.97e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 7 PDGGWGWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSG 86
Cdd:TIGR00892 12 PDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 87 FLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYG 166
Cdd:TIGR00892 92 LLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 167 LDGCLLIVGALALNILACGSLMRPLQTSDCPFPEKTapenvpdrysmyneKEknpeetmnfqdkgyssedkCLPNGDwgr 246
Cdd:TIGR00892 172 WRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKS--------------KE-------------------GLPPDG--- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 247 etslpkslaiaahtKEPETYKKKVVEQTNfcKQLAkrkwqlyrnycgetASLFKNKVFSALFIAILLFDIGGFPPSLLME 326
Cdd:TIGR00892 216 --------------STKKLSKKSTAEKIN--RFLD--------------FSLFTHRGFLVYLSGNVIMFLGFFAPIIFLV 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 327 DVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWI--NTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILG 404
Cdd:TIGR00892 266 PYAKDKGVDEYEAAF-LLSIIGFVDIFARPSCGLIAGLKWIrpHVQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFG 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 405 FLTGNWSIFPY-VTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAILPC 483
Cdd:TIGR00892 345 LSFGSVGALLFeVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAIGNYIN 424
|
490
....*....|
gi 81885900 484 WDMCNKKLPK 493
Cdd:TIGR00892 425 YRLLAKEQKA 434
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
12-477 |
2.72e-53 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 184.52 E-value: 2.72e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 172 LIVGALALNILACGSLMRPLQTSD---CPFPEKTAPenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgret 248
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPGdppAPPRSLSAA-------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 249 slpkslaiaahtkepetykkkvveqtnfckqlakrkWQLyrnycgetaSLFKNKVFSALFIAILLFDIGGFPPSLLMEDV 328
Cdd:cd17423 197 ------------------------------------FGL---------SLLTHRAFLRYALATTLINTGYFIPYVHLVAH 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 329 ARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTG 408
Cdd:cd17423 232 ARALGLGEYQAAF-VVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAG 310
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 409 NWS-IFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17423 311 ALApLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLILL 380
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
12-478 |
2.29e-46 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 165.31 E-value: 2.29e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 172 LIVGALALNILACGSLMRPLqtsdcpfpektapenvpdrysmynekeKNPEetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17422 161 LVVGALQLNIVVCGALLRVL---------------------------KEPG----------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetaslFKNKVFSALFIAillfdIGGFPPSLLMEDVARS 331
Cdd:cd17422 185 -----------------------------------------------FICYALFGLFAT-----LGFFAPQLYIIPLSLS 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 332 YHVrEEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNWS 411
Cdd:cd17422 213 LGI-DQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVA 291
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 412 ---IFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17422 292 gthIPLLAEDDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLAL 361
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
12-478 |
2.71e-42 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 155.38 E-value: 2.71e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFG-----EGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSG 86
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTklgdpEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 87 FLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYG 166
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 167 LDGCLLIVGALALNILACGSLMRPLQTSDCPFPEKtapenvPDRYSMYNEKEKNPEETMNFQdkgyssedkclpngdwgr 246
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSK------PGRRTLHSRINLFLRKIFNVE------------------ 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 247 etslpkslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLME 326
Cdd:cd17420 217 ---------------------------------------------------IFKRKRYVIWALGIPLALFGYFVPYVHLM 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 327 DVARSYHVREEDLTMPLISIfGIMTAVGKLLLGILADF-KWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGF 405
Cdd:cd17420 246 KFVKEEFFPGKDVNVPLMCI-GITSGIGRLIFGVIADMpPGVKKMYLQVLSFVSIGLMSMMIPLCNSFGILISVCLVMGL 324
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81885900 406 LTGNW-SIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17420 325 FDGCFiSIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFF 398
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
12-478 |
1.56e-39 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 147.28 E-value: 1.56e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGssVGL-FIYAALQRMLIEFYGLDGC 170
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSG--MGLtFALAPFTQLLLDEYDWQGA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 171 LLIVGALALNILACGSLMRPLQTsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretsl 250
Cdd:cd17421 159 LLIFGGIMLNLVASGMLLRPIDF--------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 251 pkslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetaSLFKNKVFSALFIAILLFDIGGFPPSLLMEDVAR 330
Cdd:cd17421 182 ----------------------------------------------SLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARAR 215
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 331 SYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNW 410
Cdd:cd17421 216 TLGIDPMDASF-IISVAGITETVAQLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGY 294
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81885900 411 -SIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17421 295 lALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFL 363
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
12-479 |
8.00e-36 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 136.78 E-value: 8.00e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 172 LIVGALALNILACGSLMRPLqtsdcpfpektapenvpdrysmynekeknpeetmNFqdkgyssedkclpngdwgretslp 251
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRPL----------------------------------DF------------------------ 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetaSLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17430 183 ---------------------------------------------SVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKD 217
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 332 YHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWI--NTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGN 409
Cdd:cd17430 218 IGVPDTEAAF-LLSILGFIDIFARPACGVVAGLKWVrpRVVYLFSFAMLFNGLTDLCSATAADYGGLVVFCVFFGISYGM 296
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81885900 410 WSIFPY-VTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17430 297 VGALQFeVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLALG 367
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
12-479 |
3.61e-35 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 134.94 E-value: 3.61e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 172 LIVGALALNILACGSLMRPLQTSDcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17424 161 LILGGFVLNLCVCGALMRFLLMPD-------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetaslfknkvFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17424 185 ----------------------------------------------------FLVLAVSVLFLAYGCSPPFVYLVPYALS 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 332 YHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWINTlYLYVATLIITGL-ALCA--IPFAKSYVTLAILSGILGFLTG 408
Cdd:cd17424 213 VGVSHQQAAF-LMSILGVIDIIGNITFGWLTDRRCLKK-YRYFCYLFAVGMdGLCClfLPILKTFPLLVPFSFTFGYFDG 290
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81885900 409 NW-SIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17424 291 AYvALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLGSA 362
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
12-476 |
3.12e-29 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 118.74 E-value: 3.12e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFG-----EGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSG 86
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGskddaQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 87 FLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYG 166
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 167 LDGCLLIVGALALNILACGSLMRPLqtsdcpfpektapenVPDRYSMYNEKEKNpeetmnfqdkgyssedKCLPngdwgr 246
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPL---------------VPMKKDKEGKKRKF----------------KCPP------ 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 247 etslpkslaiaahtkepetykKKVVEQTNFCKQLAKRKWQLyrnycGETASLFknkvfsalfiaillfdiGGFPPSL-LM 325
Cdd:cd17464 204 ---------------------LKKIFNFNIWKSTGYRIWAF-----GIPAALF-----------------GYFVPYVhLM 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 326 EDVARSY--HVREEDLTMPLisifGIMTAVGKLLLGILADF-KWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGI 402
Cdd:cd17464 241 NHVKERFgeDVNKEVLLMCI----GITSGIGRLIFGRVADYiPGVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLF 316
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81885900 403 LGFLTGNW-SIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFIL 476
Cdd:cd17464 317 MGLFDGCFiSIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIIL 391
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
12-479 |
6.79e-28 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 114.48 E-value: 6.79e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 172 LIVGALALNILACGSLMRPlqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17425 180 ----------------------------------------------FCSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATS 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 332 YHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWIN--TLYLYVATLIITGLA--LCAI----PFAKSYVTLAILSgil 403
Cdd:cd17425 214 NGMDESKAAL-LLSILGFINIFMRPLAGLLSGLPVFKgrRIYLFSLALLLNGLSnlICAIsasfPVLLVYCLLYSIS--- 289
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81885900 404 gfLTGNWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17425 290 --MSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGLS 363
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
12-480 |
2.13e-27 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 113.43 E-value: 2.13e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 172 LIVGALALNILACGSLMRPLQTSdcPFPEKTapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslp 251
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPIGPK--PFLDLT------------------------------------------------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 252 kslaiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:cd17426 190 ----------------------------------------------LFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKS 223
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 332 YHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWI--NTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGN 409
Cdd:cd17426 224 KQISNESAAF-LLSILAFVDMVARPSMGIVANTKWVrpRIQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGW 302
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81885900 410 WSIFPYVT-TKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAI 480
Cdd:cd17426 303 LSSVLFETlMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYLFIGM 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-477 |
7.22e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 111.75 E-value: 7.22e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 20 FFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLA 99
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 100 PNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFIYAALQRMLIEF--YGLDGCLLIVGA 176
Cdd:cd06174 82 PSFWLLLLGR-FLLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 177 LALNILACGSLMRPLQTSdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslpkslai 256
Cdd:cd06174 161 LALLAAILLLLVVPDPPE-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 257 aahtkepetykkkvveqtnfcKQLAKRKWQLYRNYCGETASLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSYHVRE 336
Cdd:cd06174 179 ---------------------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 337 EDLTMPLISIFGIMTAVGKLLLGILADfKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNWSIFPYV 416
Cdd:cd06174 238 VAVAGLLLSLFGLAGALGSLLLGLLSD-RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81885900 417 -TTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd06174 317 lIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
12-477 |
1.14e-24 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 105.43 E-value: 1.14e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLY-TATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGC 170
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAaVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 171 LLIVGALALNILACGSLMRPLQTSDcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretsL 250
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPAD------------------------------------------------------L 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 251 PKSLAIAAHTKEPETYKKKVVEQTNFckqlakrkWQLyrnycgetaslfknkvfsALFIAILLFDIGGFPPSLLMEDVAR 330
Cdd:cd17355 187 ALRAYDDASPASPGSTLKEALRSASF--------WLL------------------ALAFFLCGFAVVGLIVHLVPYLADR 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 331 SYHVREEDLTMPLISIFGImtaVGKLLLGILADFkwINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGIL-GFLTGN 409
Cdd:cd17355 241 GISPAAAAVALALIGLFNI---VGRLLSGWLGDR--YSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALfGLGWGA 315
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81885900 410 WSIFP-YVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17355 316 TVPLTaALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
42-480 |
2.13e-24 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 105.00 E-value: 2.13e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 42 DAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLY 121
Cdd:cd17353 31 SALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGIGY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 122 TATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALALNILA-CGSLMRplqtsdcpfpe 200
Cdd:cd17353 111 ITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIViGAFLIR----------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 201 ktapenvpdrysmynekeknpeetmnfqdkgyssedkcLPNGDWGRETSLPKslaiaAHTKEPETYKKKVVEQtnfckql 280
Cdd:cd17353 180 --------------------------------------DPPKGWVPPGVDPL-----ANNAENSPRDYTPREM------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 281 akrkwqlyrnycgetaslFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSYHVrEEDLTMPL-ISIFGIMTAVGKLLLG 359
Cdd:cd17353 210 ------------------LRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAG-LDAGIAALaVSILSIFNGGGRPFWG 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 360 ILADFkwINTLYLYVATLIITGLALCAIPFAKS-YVTLAILSGILGF-LTGNWSIFPYVTTKTVGIDKLAHAYGILMFFA 437
Cdd:cd17353 271 WLSDK--IGRKNTLSIAFLIQGVAMFLLPFIGSvAVLFVLGVALIGFcYGGGFALFPALTADFFGTKNAGTNYGLLYTAK 348
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 81885900 438 GLGNSLGPPIVGwFYDWTQTYDIAFYFSGfCVLLGGFILLLAI 480
Cdd:cd17353 349 GVGGLIGPIIAA-YVLYTGGYNAAFIIAA-ALSLVALALALLL 389
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
12-191 |
9.05e-24 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 102.58 E-value: 9.05e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180
....*....|....*....|
gi 81885900 172 LIVGALALNILACGSLMRPL 191
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPL 180
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-478 |
2.29e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 101.88 E-value: 2.29e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 13 WVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGG 92
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 93 LMLSSLAPNiYFLFFSYGIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCL 171
Cdd:COG2223 84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 172 LIVGALALNILACGSLMrplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkcLPNGDWGRETSLP 251
Cdd:COG2223 163 LILGILLLVVAVLAWLF--------------------------------------------------LRDPPAGAAAAAK 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 252 KSLAiaahtkepetykkkvveqtnfckqlakrkwqlyrnycgETASLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARS 331
Cdd:COG2223 193 ASLR--------------------------------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVD 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 332 YHVREEDLTMPLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIpFAKSYVTLAILSGILGFLTGNWS 411
Cdd:COG2223 235 QFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL-ALGSLWLFLVLFLLLGLALGGGN 313
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81885900 412 -IFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:COG2223 314 gAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLL 381
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
5-480 |
2.81e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 89.16 E-value: 2.81e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 5 KSPDGGWGWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIF 84
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 85 SGFLVAGGLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYAALQRMLIE 163
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 164 FYGLDGCLLIVGALALnilacgslmrplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngd 243
Cdd:COG2271 160 AFGWRAAFLILGLPGL---------------------------------------------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 244 wgretslpksLAIAAHTkepetykkkvveqtnfckqlakrkWQLYrnycgetaslfknkvFSALFIAILLFDIGGFPPSL 323
Cdd:COG2271 176 ----------LLALLRF------------------------WLLA---------------LAYFLVYFALYGFLTWLPTY 206
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 324 LMEdvarSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGIL 403
Cdd:COG2271 207 LVE----VRGLSLAQAGL-LLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLA 281
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81885900 404 GFLT-GNWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQtYDIAFYFSGFCVLLGGFILLLAI 480
Cdd:COG2271 282 GFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
12-477 |
1.43e-17 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 84.08 E-value: 1.43e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKG-----KTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSG 86
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDqavqfKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 87 FLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYG 166
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 167 LDGCLLIVGALALnILACGSLmrplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgr 246
Cdd:cd17465 161 LAHTFQVLSLFMF-IQIFLSL----------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 247 etslpkslaiaahtkepeTYKkkvveqtnfckqlakrkwqlyrnycgetasLFKNKVFSALFIAILLFDIGGFPPSL-LM 325
Cdd:cd17465 181 ------------------TYK------------------------------VFRRKTYRIWAFGIATAVLGYFVPYVhLM 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 326 EDVARSYHVREEDLTMPLisIFGIMTAVGKLLLGILAD-FKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILG 404
Cdd:cd17465 213 KYVEEEFKENKREWVLLV--CIGASSGIGRLMSGKIGDlIPGLKKIYLQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLG 290
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81885900 405 FLTGNW-SIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17465 291 LCDGCFiTIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLF 364
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-443 |
5.21e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 79.25 E-value: 5.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 6 SPDGGWGWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFS 85
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 86 GFLVAGGLMLSSLAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFIYAALQRMLIEF 164
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAA-RFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 165 YGLDGCLLIVGALALNILACGSLMrplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdw 244
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRL-------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 245 gretsLPKSLAIAAHTKEpetykkkvveqtnfckqlakrkwqlyrnycGETASLFKNKVFSALFIAILLFDIGGFPPSLL 324
Cdd:COG2814 185 -----LPESRPAARARLR------------------------------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTY 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 325 MEDVARSYHVREEDLTMPLISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILG 404
Cdd:COG2814 230 LPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLG 307
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 81885900 405 FLTG-NWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSL 443
Cdd:COG2814 308 FGFGlLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-445 |
7.77e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 75.53 E-value: 7.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 20 FFTQFLSYGSPLAVGVLYVEWL-DAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSL 98
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 99 APNIYFLFFSyGIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGAL 177
Cdd:pfam07690 82 ASSLWLLLVL-RVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 178 ALNILACGSLMRPlqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgretslpkslaia 257
Cdd:pfam07690 161 SLLAAVLLLLPRP------------------------------------------------------------------- 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 258 ahtkEPETYKKKVVEQTNFCKQLAKRkwqlyrnycgetaSLFKNKVFSaLFIAILLFDIGGFPPSLLMEDVARSYHVREE 337
Cdd:pfam07690 174 ----PPESKRPKPAEEARLSLIVAWK-------------ALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQEVLGLSAL 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 338 dLTMPLISIFGIMTAVGKLLLGILAD-FKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTG-NWSIFPY 415
Cdd:pfam07690 236 -LAGLLLGLGGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGlVFPALNA 314
|
410 420 430
....*....|....*....|....*....|
gi 81885900 416 VTTKTVGIDKLAHAYGILMFFAGLGNSLGP 445
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
32-479 |
1.38e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 69.13 E-value: 1.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 32 AVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYgI 111
Cdd:COG2807 36 SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGT-A 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 112 VVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALALNILACGSlmrpL 191
Cdd:COG2807 115 LIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWL----P 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 192 QTSDCPFPEKTAPENVPDRysmynekeknpeetmnfqdkgyssedkclpngdwgretSLPKSlaiaahtkepetykkkvv 271
Cdd:COG2807 191 LLRRRPAAAAAAPAAASLR--------------------------------------SLWRS------------------ 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 272 eqtnfckqlaKRKWQLyrnycgeTASLFknkVFSALFIAILlfdigGFPPSLLMEdvarsYHVREEDLTMpLISIFGIMT 351
Cdd:COG2807 215 ----------PLAWLL-------TLFFG---LQSLLYYAVV-----AWLPPILRD-----AGLSAATAGL-LLSLFQLAG 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 352 AVGKLLLGILADfKWINTLYLYVATLIITGLALCAIPFAKSYVTLaILSGILGFLTGnwSIFP----YVTTKTVGIDKLA 427
Cdd:COG2807 264 IPGSLLVPLLAD-RLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPW-LWAVLLGLGQG--GLFPlaltLIGLRARTPAEAA 339
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 81885900 428 HAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:COG2807 340 ALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-478 |
1.96e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 68.76 E-value: 1.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 16 VVVSFFTQFLSYGSPLAVGVLYVEwldAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLML 95
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAE---SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 96 SSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIV 174
Cdd:cd17325 78 FAFATSYWQLLLAR-FLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 175 GALALNILACGSLMRPlqtsdcpfpektapenvpdrysmynEKEKNPEETmnfqdkgyssEDKCLPNGDWGRETSLPKSL 254
Cdd:cd17325 157 AALALLALVLALLLLP-------------------------EPRPPPNKR----------AVSAARLRSGLRLLLRDRRL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 255 AIAAhtkepetykkkvveqtnfckqlakrkwqlyrnycgeTASLFKNKVFSAL--FIAILLFDIGGFPPSllmedvarsy 332
Cdd:cd17325 202 LALF------------------------------------LAIFVLAFAFGALepFLPLYAAELGGLSPA---------- 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 333 hvreeDLTMpLISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTG--NW 410
Cdd:cd17325 236 -----QIGL-LFGAQGLASALSQPPAGKLSD--RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGlvFP 307
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81885900 411 SIFPYVtTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDwTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17325 308 ATLALL-ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLFLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
295-480 |
5.99e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 66.92 E-value: 5.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 295 TASLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADfkWINTLYLYV 374
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGL-VVTAYLLGAALGAPLAGRLAD--RFGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 375 ATLIITGLALCAIPFAKSYVTLAILSGILGFLTG-NWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYD 453
Cdd:COG2814 80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180
....*....|....*....|....*..
gi 81885900 454 WTqTYDIAFYFSGFCVLLGGFILLLAI 480
Cdd:COG2814 160 LF-GWRWVFLVNAVLALLALLLLLRLL 185
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
302-484 |
8.46e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 66.43 E-value: 8.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 302 KVFSALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITG 381
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGL-LASAFFLGYALGQIPAGLLAD--RFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 382 LALCAIPFAKSYVTLAILSGILGFLTG-NWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWF---YDWTqt 457
Cdd:COG2271 87 LATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLlaaFGWR-- 164
|
170 180
....*....|....*....|....*..
gi 81885900 458 ydIAFYFSGFCVLLGGFILLLAILPCW 484
Cdd:COG2271 165 --AAFLILGLPGLLLALLRFWLLALAY 189
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
307-478 |
1.15e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 59.74 E-value: 1.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 307 LFIAILLFDIGGFPPSLLM-EDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFkwINTLYLYVATLIITGLALC 385
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGL-LLTLFSLGYALAQPLAGRLSDR--FGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 386 AIPFAKSYVTLAILSGILGFLTG-NWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYF 464
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAAFLI 156
|
170
....*....|....
gi 81885900 465 SGFCVLLGGFILLL 478
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
52-481 |
2.22e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.10 E-value: 2.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 52 AWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQY 131
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA-RALAGLAHGGFWAIAAAYAADL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 132 F-DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALAlniLACGSLMRPLqtsdcpfpektapenvpdr 210
Cdd:cd17324 116 VpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLA---LLAALLLWRL------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 211 ysmynekeknpeetmnfqdkgyssedkcLPNGDWGRETSLPKSLAIAAHTKEPetykkkvveqtnfckqlakRKWQLYRN 290
Cdd:cd17324 174 ----------------------------LPSLPPKKPGSLGLLSSLLLLLRNP-------------------RLRLAYLI 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 291 YCGETASLFknKVFSalFIAILLFDIGGFPPSLLmedvarsyhvreedltMPLISIFGIMTAVGKLLLGILADFKWINTL 370
Cdd:cd17324 207 TFLLFGGFF--ALYT--YLAPFLTDVPGFSSSAI----------------IGLLLLFGVAGVVGSPLAGRLADRGGRRAL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 371 YLYVATLIITGLALCAIPFAksyvTLAILSGILGFLTGNWSIFPYVTTKTVGI--DKLAHAYGILMFFAGLGNSLGPPIV 448
Cdd:cd17324 267 LIALLLLAAALLLLTLLGPS----PLLLLVGLVLWGLGFFAAHSALQTRVLRLapEARGLASSLYLAAYNLGGALGAALG 342
|
410 420 430
....*....|....*....|....*....|...
gi 81885900 449 GWFYDWtqtydiafYFSGFCVLLGGFILLLAIL 481
Cdd:cd17324 343 GLVLDH--------GGWAGVGWVGAALLLLALL 367
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
307-480 |
5.49e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 57.82 E-value: 5.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 307 LFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITGLALCA 386
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGL-LFALFSLGYALLQPLAGLLAD--RFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 387 IPFAKSYVTLAILSGILGFLTGN-WSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDW-TQTYDIAFYF 464
Cdd:cd06174 78 FAFAPSFWLLLLGRFLLGLGSGLiDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGWRAVFLI 157
|
170
....*....|....*.
gi 81885900 465 SGFCVLLGGFILLLAI 480
Cdd:cd06174 158 AAALALLAAILLLLVV 173
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
13-190 |
7.17e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 7.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 13 WVIVVVSFFTQFLSYGSPLAVGVLYVEwldAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGG 92
Cdd:cd17473 200 LPIYFLAFLAMLLFYVIPIQLPFLLQE---RGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 93 LMLSSLAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFIYAALQRMLI-EFYGLDGC 170
Cdd:cd17473 277 FLLLALASGLWVVLLG-AILAGLGFGLLLPTLNSWAMSLVPpELRGRAMGIVTSAFFLGQFLSPLVLGPLVnLTGGLSGA 355
|
170 180
....*....|....*....|
gi 81885900 171 LLIVGALALnILACGSLMRP 190
Cdd:cd17473 356 FLILGVLAL-VLAIVLLLLR 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-179 |
1.71e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.43 E-value: 1.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 14 VIVVVSFFTQFLSYGSPLAVGVLYVEwlDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGL 93
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAA--ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 94 MLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLL 172
Cdd:cd17325 280 LLLPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIVPpEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
....*..
gi 81885900 173 IVGALAL 179
Cdd:cd17325 359 AAAALLL 365
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-190 |
1.79e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 56.42 E-value: 1.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 13 WVIVVVSFFTQFLSYGsPLAVGVLYVEwlDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGAR--PVTIFSGFLVA 90
Cdd:COG2271 183 WLLALAYFLVYFALYG-FLTWLPTYLV--EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 91 GGLMLSSLAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQYFDSR-RGLALGLISTGSSVGLFIYAALQRMLIEFYGLDG 169
Cdd:COG2271 260 LALLLLALLPSPALAIAL-LFLAGFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 81885900 170 CLLIVGALALNILACGSLMRP 190
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
343-478 |
1.88e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 56.04 E-value: 1.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 343 LISIFGIMTAVGKLLLGILAD-FKWINTLYLYVATLIITGLALCAIPFAKS-YVTLAILSGILGFLTGNWSIFPYVTTKT 420
Cdd:cd17319 220 LAAIPFLAGAIGMILGGRLSDrLLRGARRLVIIIGLLLAAVGLLLAYLTTSpVVAVILLSLAGFGIGAASPVFWSLPADL 299
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 81885900 421 VGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17319 300 LPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-179 |
1.97e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.43 E-value: 1.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 5 KSPDGGWGWVIVVVSFFTQ--FLSYGSPLAVgvlyvewlDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVT 82
Cdd:COG2223 203 RDPRFWLLSLLYFGTFGSFigFSSWLPPYLV--------DQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 83 IFSGFLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSR-RGLALGLISTGSSVGLFIYAALQRML 161
Cdd:COG2223 275 LIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKnAGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
170
....*....|....*....
gi 81885900 162 IEFYG-LDGCLLIVGALAL 179
Cdd:COG2223 355 LDATGsYTAAFLVFAVLAL 373
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
301-477 |
3.94e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 55.24 E-value: 3.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 301 NKVFSALFIAILLFDIGGFPPSLLMedvarsYHVREEDLTMPLI----SIFGIMTAVGKLLLGILADFkwINTLYLYVAT 376
Cdd:cd17370 199 PKAFWLYLLAVALFALGNFSFAFLI------LRAQELGLSAALIpllyALFNLVYALAAYPAGRLSDR--IGRKKLLILG 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 377 LIITGLALCAIPFAKSYVTLAILSGILGFLTGNW-SIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWT 455
Cdd:cd17370 271 YLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI 350
|
170 180
....*....|....*....|..
gi 81885900 456 QtYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17370 351 S-PSAAFLFSAVLALIALLLLL 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
296-484 |
5.59e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.91 E-value: 5.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 296 ASLFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMPLISIFGIMTAVGKLLLGILAdfKWINTLYLYVA 375
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA--KRFGKKKAFII 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 376 TLIITGLALCAIPFAK--SYVTLAILSGILGFLTG-----NWSIF----PYVTTKTvGIDKLAHAYGILMFFAGLGNSLG 444
Cdd:COG2211 300 GLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGailvlPWAMLadvvDYDEWKT-GRRREGLYFGIFTFAIKLGQALA 378
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 81885900 445 PPIVGWFYDWT-------QTYDIAFYFSGFCVLLGGFILLLAILPCW 484
Cdd:COG2211 379 GALAGLLLALFgyvagaaQSPSALTGIRLLFFLLPAVLLLLAALLLL 425
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
343-480 |
6.53e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.50 E-value: 6.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 343 LISIFGIMTAVGKLLLGILADFkwINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTG-NWSIFPYVTTKTV 421
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDR--FGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAaVWPAAMALIADIA 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 81885900 422 GIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYFSGFCVLLGGFILLLAI 480
Cdd:cd17325 114 PPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALALLALVLALLLL 171
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-179 |
7.64e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 54.05 E-value: 7.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 1 MEFQKSPDGGWGWVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSlasgVGLLASPVCSLFVSS----F 76
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVS----AYLLGRAIGLLLFGRlgdrY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 77 GARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYA 155
Cdd:COG0477 77 GRKRVLLIGLLLFGLASLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGP 155
|
170 180
....*....|....*....|....
gi 81885900 156 ALQRMLIEFYGLDGCLLIVGALAL 179
Cdd:COG0477 156 LLGGLLVAALGWRWIFLINAPLGL 179
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
306-482 |
1.12e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.71 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 306 ALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWINTLYLYVATLIITGLALC 385
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGL-LVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 386 AipFAKSYVTLAILSGILGFLTGN-WSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYF 464
Cdd:cd17324 82 A--LAPSFALLLLARALAGLAHGGfWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-GWRAAFLA 158
|
170
....*....|....*...
gi 81885900 465 SGFCVLLgGFILLLAILP 482
Cdd:cd17324 159 IAVLALL-AALLLWRLLP 175
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-481 |
6.29e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 51.39 E-value: 6.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 14 VIVVVSFFTQFLSYGSplaVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGL 93
Cdd:COG0738 11 IAIYLLFFLWGFATAL---WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 94 MLSSLAPNIYFLFFSYgIVVGLGCGLLYTAT----VTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDG 169
Cdd:COG0738 88 LLFALAPSYPLLLLAL-FLLGLGLGLLDVAAnpyvAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 170 CLLIVGALALNILACGSlmrplqtsdcpfpektapenvpdrysmynekeknpeetmnfqdkgyssedkclpngdwgreTS 249
Cdd:COG0738 167 YLILAVLLLLLALLFLR-------------------------------------------------------------SK 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 250 LPKSLAIAAHTKEPETykkkvveqtnfckqlakrkwqlyrnycgETASLFKNKVFSALFIAILLF-----DIGGFPPSLL 324
Cdd:COG0738 186 LPEIEEEEEEAAGSAA----------------------------SLKSLLKNPRLLLGGLAIFLYvgaegAIGDWLPLYL 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 325 MEDVARSyhvreEDLTMPLISIFGIMTAVGKLLLGILAD-FKWINTLYLYvaTLIITGLALCAIPFAKSYVTLAILsGIL 403
Cdd:COG0738 238 KDVLGLS-----EATAALGLSLFWGGMTIGRFLGGFLLKrFGPVRLLRLS--ALLAAVGLLLALLAPGPWLALIGL-ALV 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 404 GFLTGNwsIFPyvTTKTVGIDKL----AHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYFSGFCVLLggfILLLA 479
Cdd:COG0738 310 GLGLSL--MFP--TIFSLALDGLgkrtAAAVSAVLIMGIVGGAIGPPLIGFLADAF-GLRAAFLVPLVCYLL---ILLLA 381
|
..
gi 81885900 480 IL 481
Cdd:COG0738 382 LA 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
303-480 |
7.12e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.42 E-value: 7.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 303 VFSALFIAILLFDIGGFPPSLLmedvARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKwINTLYLYVATLIITGL 382
Cdd:cd17474 204 LVSAFLYFFLYFAFLTYLPFLL----ELLYGISPIIIGL-LFAGWSVLLALGSLFVGRLLKKR-FGARRILVIGLLLYAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 383 ALCAIPFAKSYVTLAILSGILGFLTGNwsIFPYVTT---KTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYd 459
Cdd:cd17474 278 SLLLLGFVPSLALLLIAIVLFGLGLGL--NLPLLTTlvtELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLS- 354
|
170 180
....*....|....*....|.
gi 81885900 460 iAFYFSGFCVLLGGFILLLAI 480
Cdd:cd17474 355 -APFLVGAAIALAAAVLLALL 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-189 |
1.92e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 50.24 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 11 WGWVIVVVSFFTQFLSYGSPLAVG---VLYVEwlDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGF 87
Cdd:COG0738 207 LKNPRLLLGGLAIFLYVGAEGAIGdwlPLYLK--DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 88 LVAGGLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGL 167
Cdd:COG0738 285 LAAVGLLLALLAPGPWLALIGL-ALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGL 363
|
170 180
....*....|....*....|..
gi 81885900 168 DGCLLIVGALALNILACGSLMR 189
Cdd:COG0738 364 RAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
343-479 |
2.55e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 2.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 343 LISIFGIMTAVGKLLLGILAdfKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFltGNWSIFPYVTTKTVG 422
Cdd:cd17473 238 ALAIASLAGAIGALLFGRLK--RRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGL--GFGLLLPTLNSWAMS 313
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81885900 423 IDKLAH-----AYGILMFFagLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17473 314 LVPPELrgramGIVTSAFF--LGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
343-475 |
3.32e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.09 E-value: 3.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 343 LISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITGLALCAIPFAKSY-VTLAILSGILGFLTGnwSIFPY---VTT 418
Cdd:cd17477 228 LLAAFVLGGLLLQWPLGWLAD--RFDRRRVLLGCALLGALAALLLPLVPGLpLALLVLLFLWGGAAG--PLYTLalaLAG 303
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 81885900 419 KTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFI 475
Cdd:cd17477 304 DRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-179 |
5.71e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 48.58 E-value: 5.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 11 WGWVIVVVSFFTQFLSYGSPLAVGVLYveWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVA 90
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLF--LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLM 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 91 GGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSR-RGLALGLISTGSSVGLFIYAALQRMLI-EFYGLD 168
Cdd:cd06174 281 ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEiRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLT 360
|
170
....*....|.
gi 81885900 169 GCLLIVGALAL 179
Cdd:cd06174 361 GAFLVLAVLLL 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
13-157 |
5.72e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 5.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 13 WVIVVVSFFTQFLSYGSPLAVGVLYVEwlDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFL-VAG 91
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFK--YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLaALG 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYT---ATVTITCQY-----FDSRRGLALGLISTGSSVGLFIYAAL 157
Cdd:COG2211 308 LLLLFFLGPGNLWLLLVLAALAGIGLGAILVlpwAMLADVVDYdewktGRRREGLYFGIFTFAIKLGQALAGAL 381
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
56-183 |
1.31e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.20 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 56 SLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQYFD-S 134
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLA-AVLYGLGFGLLFPALQALAVDLVPpH 312
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 81885900 135 RRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALALNILA 183
Cdd:cd17489 313 RRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
53-191 |
1.36e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 47.19 E-value: 1.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 53 WVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYGIVvGLGCGLLYTATVTITCQYF 132
Cdd:cd17330 38 LLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLD-GLTGGNVSVAQAYIADITD 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 133 DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALAL-NILACGSLMRPL 191
Cdd:cd17330 117 EEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALlNLVLVLFFLPPL 176
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
13-179 |
1.94e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 46.83 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 13 WVIVVVSFFTQFLSYGSPLAVGVLYVEWLdafGEGKGKTAWVGSLASGVGLLASPVC-SLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17490 197 LFFSLLAILQQMITFSTTFGFTPLIAKQL---GASSFQLGLLSIIYLLPNALASLLSgTLFYKKLGERNTIIIGFLLLGA 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFDSR-RGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGC 170
Cdd:cd17490 274 YCFLIPFAPNLTLLYLLQ-ALNGFGTGILFPLLMSLSIEGVPAEqRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTG 352
|
....*....
gi 81885900 171 LLIVGALAL 179
Cdd:cd17490 353 FFVIGVIAL 361
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
343-481 |
5.44e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.26 E-value: 5.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 343 LISIFGIMTAVGKLLLgILADFKWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGnwSIFPYVTT---K 419
Cdd:cd17330 215 LLALVGIAGILAQLLL-IPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTG--IVFPALSAllsK 291
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81885900 420 TVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYdwtqtydiAFYFSGFCVLLGGFILLLAIL 481
Cdd:cd17330 292 SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLY--------SFLGPGVPFLLAAGLLLIALF 345
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-189 |
2.58e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.41 E-value: 2.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 13 WVIVVVSFFTQFLSYGsplaVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGG 92
Cdd:cd17355 213 WLLALAFFLCGFAVVG----LIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALG 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 93 LMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRR-GLALGLISTGSSVGLFIYAALQRMLIEFYGlDGCL 171
Cdd:cd17355 289 LALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSyGTLFGLVFAPHQLGSALGPWLGGLLYDRTG-SYTA 367
|
170
....*....|....*...
gi 81885900 172 LIVGALALNILACGSLMR 189
Cdd:cd17355 368 AWALAVALGLIAALLVLP 385
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-153 |
2.66e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.18 E-value: 2.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 13 WVIVVVSFFTQFLSYGSPLAVGVLYVEwldAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARP---VTIFSGFLV 89
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQE---VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81885900 90 AGGLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFI 153
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLAL-LLLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
9-188 |
3.02e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 43.02 E-value: 3.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 9 GGWGWVIVVVSFFTqFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVG-SLASGVGLLASpvcSLFVSSFGARPVTIFSGF 87
Cdd:cd17393 198 NRLLLLLGLLALAA-ALAEGAAADWSALYLRDVLGASAALAALGYAVfSLAMTVGRLFG---DRLVDRFGDVAVLRAGAL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 88 LVAGGLMLSSLAPNIYFLFFSYGIvVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGL 167
Cdd:cd17393 274 LAALGLLLALLAPSVWVALAGFAL-MGLGLSVVVPLAFSAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGL 352
|
170 180
....*....|....*....|.
gi 81885900 168 DGCLLIVGALALNILACGSLM 188
Cdd:cd17393 353 RTAFLVVALLALLVALLARAV 373
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
328-478 |
3.16e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 43.13 E-value: 3.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 328 VARSYHVREEDLTMP----LISIFGIMTAVGKLLLGILADFKwiNTLYLYVATLIITGLALCAIPFAKSYVTLAILSGIL 403
Cdd:TIGR00881 16 LAMPYLVEEIGLSKTdlglLLSSFSIAYGISKFVMGSVSDRS--NPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 404 GFLTG-NWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVG----WFYDWTQTydiaFYFSGFCVLLGGFILLL 478
Cdd:TIGR00881 94 GIFQGmGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfgiaELYSWHWV----FIVPGIIAIIVSLICFL 169
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
343-504 |
3.26e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.97 E-value: 3.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 343 LISIFGIMTAVGKLLLGILAD---FKWIntlylYVATLIITGLALCAIPFAKSYVTLAILSGILGFltgNWSIFPYVT-- 417
Cdd:cd17489 36 VVGLFTLAALLARPFAGRLLDrfgRKRL-----LLIGLLIFALATLLYLLATSVALLLVLRLIHGI---GWGAFTTAAat 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 418 --TKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQtYDIAFYFSGFCVLLGgfILLLAILPCwdmCNKKLPKPA 495
Cdd:cd17489 108 lvADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVAAVLALLA--LLLVFLVKD---PPPVAAEEA 181
|
....*....
gi 81885900 496 VPTTFFYKV 504
Cdd:cd17489 182 EAGTRAFRR 190
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
54-207 |
3.36e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.93 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 54 VGSLASGVGLLAS---PVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQ 130
Cdd:cd17478 33 AGLLVSVFSITSSllqPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-ALAGIGSAAFHPEGARLASQ 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81885900 131 YFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGcLLIVGALALniLACGSLMRPLQTSDCPFPEKTAPENV 207
Cdd:cd17478 112 AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLG-LLILLIIPG--LAVALLLLRLRPLKKPEAKKAAAKSS 185
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
343-453 |
3.90e-04 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 42.62 E-value: 3.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 343 LISIFGIMTAVGKLLLGILADF-----KWINTLYLyVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGN-WSIFPYV 416
Cdd:cd17354 235 LVSLFSIFSFLGRLLSGLLSDLfvrkfRLPRPSRM-VLLLLILSLGHLLQAFGLPSGALYVASALIGFGYGGlFSIAPTI 313
|
90 100 110
....*....|....*....|....*....|....*..
gi 81885900 417 TTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYD 453
Cdd:cd17354 314 VSELFGLKNFGTNYGFLMLAPAIGSLIFSVIYAGVYY 350
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
12-157 |
4.00e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.55 E-value: 4.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 12 GWVIVVVSFFTQFLSYGSPLAVGVLYvewldaFGEGKGKTAWVGSLA----SGVGLLASPVCSLFVSSFGARPVTIFSGF 87
Cdd:cd17321 169 TFSGAVLAAFLLGAALGGLLFLLPLY------LQGVLGYSPLQAGLAllplALAMLVAAPLAGRLADRFGPRLVLVAGLL 242
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81885900 88 LVAGGLMLSSL--APNIYFLFFSYGIVVGLGCGLLYTA-TVTITCQYFDSRRGLALGLIST----GSSVGLFIYAAL 157
Cdd:cd17321 243 LTAVGLLLLALlgADSSVWLLLPGLVLLGLGLGLFATPlTNAALSSVPKEKAGAASGILNTarqlGGALGVALLGAL 319
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
303-478 |
5.33e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 42.26 E-value: 5.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 303 VFSALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFkwINTLYLYVATLIITGL 382
Cdd:cd17312 4 IFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGI-IGSAFLIAYAVGKFISGFLSDR--SNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 383 ALCAIPFAKSYVTLAILSGILGFLTG-NWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQtYDIA 461
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSmGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYG-WRAA 159
|
170
....*....|....*..
gi 81885900 462 FYFSGFCVLLGGFILLL 478
Cdd:cd17312 160 FLVPGIVGLVVAIILFF 176
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
345-479 |
5.42e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.20 E-value: 5.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 345 SIFGIMTAVGKLLLGILADFKwiNTLYLYVATLIITGLALCAIPFAKSyVTLAILSGILgFLTGNWSIFPYVTTKTVGI- 423
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRK--GPKTVIIPGLLLLALGLLLLSFAGS-PWMLLLAAVL-YGLGFGLLFPALQALAVDLv 309
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 81885900 424 --DKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQtYDIAFYFSGFCVLLGGFILLLA 479
Cdd:cd17489 310 ppHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
13-189 |
6.82e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.79 E-value: 6.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 13 WVIVVVSFFTQFLSYGSPLAVGVLyvewldaFGEGKGKTAWVGSLASG--------VGLLASPVCSLFVSSFGARPVTIF 84
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQL-------LQLPTPTGFGLGITEAGllllpgalVMLIAGPLAGRLIARVGPRRVLLI 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 85 SGFLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLIST----GSSVGLFIYAALQR 159
Cdd:cd17504 253 GLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPpDRTGIATGMNTVlrtiGSAIGPAIAGAILT 332
|
170 180 190
....*....|....*....|....*....|....*....
gi 81885900 160 MLIEFYGLDGC---------LLIVGALALNILACGSLMR 189
Cdd:cd17504 333 TYTVSITSGGVptegayvlaFLIGAALALAALLLSLLIP 371
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
57-179 |
7.76e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.76 E-value: 7.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 57 LASGVGLLASPVCSLFVSSFGARPVTIF---SGFLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCqyfD 133
Cdd:cd17370 242 LFNLVYALAAYPAGRLSDRIGRKKLLILgylSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVP---A 318
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 81885900 134 SRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALAL 179
Cdd:cd17370 319 ELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLAL 364
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
301-479 |
9.30e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.45 E-value: 9.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 301 NKVFSALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKwiNTLYLYVATLIIT 380
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGL-LLAAFGVGALLGALLLGRLSKRR--RRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 381 GLALCAIPFAKSYVTLAILSGILGFLTGNWSIfPYVTT--KTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTY 458
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNV-PLNTLlqLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL-GL 362
|
170 180
....*....|....*....|.
gi 81885900 459 DIAFYFSGFCVLLGGFILLLA 479
Cdd:cd06173 363 SAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
11-188 |
1.11e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.41 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 11 WGWVIVVVSFFTQFLSYGSplAVGVLYVEwldAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFS-GFLV 89
Cdd:cd17320 204 LGYALALGLSFAGLFAYLA--AAPFIYIE---QLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGlLLLL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 90 AGGLML---SSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYG 166
Cdd:cd17320 279 AAALVLllaALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTA 358
|
170 180
....*....|....*....|..
gi 81885900 167 LdgcLLIVGALALNILACGSLM 188
Cdd:cd17320 359 L---PMGLLILVLGLLALLLLI 377
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
295-477 |
1.29e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.15 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 295 TASLFKNKVFSALFIAILLFD-----IGGFPPSLLMEdvarSYHVREEDLTMpLISIFGIMTAVGKLLLGILADFKWINT 369
Cdd:cd17333 192 ASRLLRNPSIILGALALFLYVgaetaFSSWVPSYLVE----KKHVSDGLAGY-LLSGFWVGITIGRLLGGPISRRIKPHT 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 370 LYlyVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGNwsIFPYVTTKTVGIDKLAH--AYGILMFFAGLGNSLGPPI 447
Cdd:cd17333 267 LL--VLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAA--LFPTILSLGISNLPYAKgkGTSVLLAAGSIGGAIIPFI 342
|
170 180 190
....*....|....*....|....*....|
gi 81885900 448 VGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17333 343 MGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
343-477 |
1.32e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.05 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 343 LISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITGLALCAIPFA---KSYVTLAILSGILGFLTGNWSIFPYVTTK 419
Cdd:cd17316 218 YLLLISLGALVGALIAGLLSD--RIGRKKTLVIGLILSGILALPLFYLlsgSPTLLLLLLFILSFFVGGVWGALYAYLAE 295
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 81885900 420 TVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17316 296 LFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
352-477 |
1.43e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.07 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 352 AVGKLLLGILADFKWI-NTLYLYVATLIITGLALCAIPFAKS---YVTLAILSGILGFLTGNW-SIFPYVTTKTVGIDKL 426
Cdd:cd17475 248 ALGRIGLGRVSDRVFGgRRRPVLVITAAIAAAALLVLSLLSPgtpLWLLVLLLILLGLFAIGWnGLYLTLVAESAGPEQA 327
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 81885900 427 AHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17475 328 GTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
343-480 |
1.72e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 40.63 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 343 LISIFGIMTAVGKLLLGILADfkWINTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGnwSIFP---YVTTK 419
Cdd:cd17319 43 IASAFFLGYALFQVPGGWLLD--RFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA--GFFPgaiKALAE 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81885900 420 TVGIDKLAHAYGILMFFAGLGNSLGPPIVGW---FYDWTQtydiAFYFSGFCVLLGGFILLLAI 480
Cdd:cd17319 119 WFPARERGRATGLFNSGAPLGAAIGPPLSGWlllLFGWRW----AFIIEGLLGLLLAVLWWFYL 178
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
15-189 |
1.77e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.66 E-value: 1.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 15 IVVVSFFtQFLSYGSPLAVGVLYVEwldafgEGKGKTAWVG---SLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAG 91
Cdd:cd17489 1 ILLANFF-FFLSFYLLLPVLPLYAH------DLGGSEAVAGlvvGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 92 GLMLSSLAPNIyFLFFSYGIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGC 170
Cdd:cd17489 74 ATLLYLLATSV-ALLLVLRLIHGIGWGAFTTAAATLVADIIPpSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVL 152
|
170
....*....|....*....
gi 81885900 171 LLIVGALALNILACGSLMR 189
Cdd:cd17489 153 FIVAAVLALLALLLVFLVK 171
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
300-478 |
1.92e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.18 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 300 KNKVFSALFIAILLFDIGGFPPSLLMEDVARSYHVREEDLTMpLISIFGIMTAVGKLLLGILADfkWINTLYLYVATLII 379
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGW-IVSAYLLGRAIGLLLFGRLGD--RYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 380 TGLALCAIPFAKSYVTLAILSGILGF-LTGNWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTY 458
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL-GW 167
|
170 180
....*....|....*....|
gi 81885900 459 DIAFYFSGFCVLLGGFILLL 478
Cdd:COG0477 168 RWIFLINAPLGLLALVLRLR 187
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
343-495 |
1.97e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.62 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 343 LISIFGIMTAVGKLLLGILADFKwiNTLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFltGNwSIF----PYVTT 418
Cdd:cd17478 36 LVSVFSITSSLLQPLFGYLADRK--PRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI--GS-AAFhpegARLAS 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81885900 419 KTVGIDKlAHAYGILMFFAGLGNSLGPPIVGWFydwtqtYDIAFYFSGFCVLLGGFILLLAILPCWDMCNKKLPKPA 495
Cdd:cd17478 111 QAAGGRR-GLAMSIFSVGGNLGFALGPLIAAAL------VALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKA 180
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
297-478 |
3.18e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.90 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 297 SLFKNK---VFSalFIAILLFDIG-----GFPPSLLMEDVARSYHvreedLTMpLISIFGIMTAVGKLLLGILAdFKWIN 368
Cdd:cd17490 189 SVLKDKkllFFS--LLAILQQMITfsttfGFTPLIAKQLGASSFQ-----LGL-LSIIYLLPNALASLLSGTLF-YKKLG 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 369 TLYLYVATLIITGLALCAIPFAKSYVTLAILSGILGFLTGnwSIFPYVTT---KTVGIDKLAHAYGILMFFAGLGNSLGP 445
Cdd:cd17490 260 ERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTG--ILFPLLMSlsiEGVPAEQRSTAMGFFQAIYALGMFLGP 337
|
170 180 190
....*....|....*....|....*....|...
gi 81885900 446 PIVGWFYDWTqTYDIAFYFSGFCVLLGGFILLL 478
Cdd:cd17490 338 VLVGIISEAF-GLQTGFFVIGVIALLAAILSLA 369
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
281-477 |
3.40e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.91 E-value: 3.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 281 AKRKWQLYRNYCGETASLFKNKVF--SALFIAILLFDIGG---FPPSLLMedvaRSYHVREEDLTmPLISIFGIMTAV-- 353
Cdd:cd17328 186 GVMAKSTATSFLADLKALAKNPSFilSTLGFTAVSFVTGAlafWAPTFFL----RAFGVGDLSSA-DVGLIFGAITCIag 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 354 --GKLLLGILADF--KWINTLYLYV---ATLIITGLALCAIPFAKS--YVTLAILSGILGFLTGNWSIFPYVTTKTVGID 424
Cdd:cd17328 261 vlGVLLGGILADRlrRKTPRADPLVcavGLLAAAPFLFLALVLALSnlLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPT 340
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81885900 425 KLAHAYGILMFFAG-LGNSLGPPIVGWFYDWTQTYDI-----------AFYFSGFCVLLGGFILL 477
Cdd:cd17328 341 RRSTASAIQILLSHlLGDAGSPYLIGLISDLLRQNKDsplaeaaslqyALLLCSFVLVLGGFFFL 405
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
41-188 |
4.41e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.49 E-value: 4.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 41 LDAFGEGKGKTAWVGSLASgVGLLASPVCSLFVSS-FGARPVTIFSGFLVAGGLMLSSLAPNIY-FLFFSYGIVVGLGcG 118
Cdd:cd17365 26 AQDWGLSPAQLGPVGSAAL-FGMAIGALLAGPLADrFGRKRVLLVSVALFGLFTLLTAFAQSVLqLALLRFLTGLGLG-A 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81885900 119 LLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLI--VGALALNILACGSLM 188
Cdd:cd17365 104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLggVPPLILLPLLRGTLL 175
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
19-179 |
4.58e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.53 E-value: 4.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 19 SFFTQFLSYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVtIFSGFLVAGGLMLSSL 98
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRV-LAVGLLLMGAAALLMA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 99 APNIYFLFFSYGIVVGLGCGLLYTATVTITCQYF-DSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGAL 177
Cdd:cd17475 80 LVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFpPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV 159
|
..
gi 81885900 178 AL 179
Cdd:cd17475 160 SI 161
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
76-188 |
5.44e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.08 E-value: 5.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 76 FGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFD-SRRGLALGLISTGSSVGLFIY 154
Cdd:cd17321 58 FGRKRVFLIGLALFGLASLLCALAPSLAFLIAAR-ALQGIGAAAIMPASLALIAATFPgERRGRALGLWGAVVGIGAALG 136
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 81885900 155 AALQRMLIEFYG---------------LDGCLLIVGALALNILACGSLM 188
Cdd:cd17321 137 PLLGGLLLELFGwrwiflinvpiglvaLLLARTFSGAVLAAFLLGAALG 185
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
13-122 |
6.08e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 39.13 E-value: 6.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 13 WVIVVVSFFTQFLSYGSPLAVGVLYVEWLDAfgeGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPV-TIFSGFLVAG 91
Cdd:cd17332 223 FLILLLAYLLYFLAFNIVNTVLVYYFKYVLG---GRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAfFIGLLLAILG 299
|
90 100 110
....*....|....*....|....*....|.
gi 81885900 92 GLMLSSLAPNIYFLFFSYGIVVGLGCGLLYT 122
Cdd:cd17332 300 LLLLFFLPPGNLVLILVLAVLAGIGYGGANL 330
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
40-183 |
6.32e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 6.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 40 WLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYgIVVGLGCGL 119
Cdd:cd17477 22 RLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLR-FVMGIGLAG 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81885900 120 LYTATVT-ITCQYFDSRRGLALGLISTGSSVGLfiyaALQRMLIEFYGLDGCLLIVGALALNILA 183
Cdd:cd17477 101 LFVVSESwLNALATNENRGRVLGLYSTVLGLGF----ALGPLLLALVGTAGALPFLIAAVLLLLA 161
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
51-162 |
8.57e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.44 E-value: 8.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 51 TAWVGSLASgVGLLASPVCSLF----VSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFsYGIVVGLGCGLLYTATVT 126
Cdd:cd17371 33 EAEAGLLGT-VTLAGGAIGGILggilADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLI-LRALAGLGFGGEWAAGAA 110
|
90 100 110
....*....|....*....|....*....|....*..
gi 81885900 127 ITCQYFDSR-RGLALGLISTGSSVGLFIYAALQRMLI 162
Cdd:cd17371 111 LMAEYVPARhRGKALGYVQSGWAVGWLLATLLAALLF 147
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
343-477 |
8.67e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.31 E-value: 8.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81885900 343 LISIFGIMTAVGKLLLGILADFkwINTLYLYVATLIITGLALCAIPFAKSYVTLaILSGILGFLTGnwSIFPY--VTTKT 420
Cdd:cd17478 235 LLSLFLFAGAIGTLIGGPLSDR--FGRRRVIIASLLLAAPFLLLFLLTPGIWSY-ILLVLAGFLLF--ASFPVtvVLAQE 309
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 81885900 421 VGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYFSGFCVLLGGFILL 477
Cdd:cd17478 310 LLPGNVGLASGLMMGLSFGLGGIGAPVLGALADAF-GLESVLLILALLPLLGALLAF 365
|
|
| |
