NCBI Conserved Domain Search

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

450-627

6.17e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 83.10 E-value: 6.17e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:COG2814   14 ALALGAFLsGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigM 608
Cdd:COG2814   94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLADLFGWRWVF----L 168

                        170
                 ....*....|....*....
gi 187610244 609 ACLVILLLFALIQWLAVPD 627
Cdd:COG2814  169 VNAVLALLALLLLLRLLPE 187

PRK09874

multidrug efflux MFS transporter MdtG;

76-140

6.69e-05

multidrug efflux MFS transporter MdtG;

Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 46.07 E-value: 6.69e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADRfKKGKIVLLFSLL 140
Cdd:PRK09874  24 FLTGAAFSLVMPFLPLYVEQLGVTGHSalnmwSGLVFSITFLFSAIASPFWGGLADR-KGRKIMLLRSAL 92

Name

Accession

Description

Interval

E-value

MFS_MFSD6

cd17335

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...

70-622

1.23e-172

Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 501.34 E-value: 1.23e-172

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  70 ISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGI 149
Cdd:cd17335    1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 150 GFVkpatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlqpq 229
Cdd:cd17335   81 FFV----------------------------------------------------------------------------- 83

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 230 tgeitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqevEAIFLVILVVVIIGEFFSASSVTIV 309
Cdd:cd17335   84 -------------------------------------------------------AQIFWLLLLLVILGAFFSAPVVPLV 108

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 310 DTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIevlidgkgckppeYRNYQIVFIVFGVLMTMALIVATQF 389
Cdd:cd17335  109 DSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST-------------YKNYTIAFYVFAVLMLLALLLALKF 175

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 390 RFRYNHfknddskgkeveipqvernnstesseetptttsHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLY 469
Cdd:cd17335  176 PFRPKH---------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLF 222

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 470 WHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAA 549
Cdd:cd17335  223 WHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFAL 302

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 187610244 550 IWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQW 622
Cdd:cd17335  303 VWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375

MFS_1_like

pfam12832

MFS_1 like family; This family contains proteins related to the MFS superfamily.

68-604

8.94e-73

MFS_1 like family; This family contains proteins related to the MFS superfamily.

Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 241.77 E-value: 8.94e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244   68 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNL 147
Cdd:pfam12832   1 LWRLKGFYFFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  148 GIGFVKPatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlq 227
Cdd:pfam12832  81 SVLFIPI------------------------------------------------------------------------- 87

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  228 pqtgeitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqevEAIFLVILVVVIIGEFFSASSVT 307
Cdd:pfam12832  88 ---------------------------------------------------------SLTFWWLALLVVLFSFFWNAILP 110

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  308 IVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLidgkgckppeyrnYQIVFIVFGVLMTMALIVat 387
Cdd:pfam12832 111 QFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLL-------------PSVLFYLFAALMLLSLLL-- 175

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  388 qfrfrynhfknddskgkeveipqvernnstesSEETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTF 467
Cdd:pfam12832 176 --------------------------------PLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTF 223

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  468 LYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYL-ENAWTVLPMEVLQGVT 546
Cdd:pfam12832 224 LFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAIS 303

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 187610244  547 HAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR 604
Cdd:pfam12832 304 FGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFR 361

MFS_MFSD6L

cd17479

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...

71-618

2.52e-44

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 164.02 E-value: 2.52e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  71 SKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLgig 150
Cdd:cd17479    1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYL--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 151 fvkpatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptLQPQt 230
Cdd:cd17479   78 ---------------------------------------------------------------------------LYHQ- 81

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 231 geitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqeveaIFLVILVVVIIGEFFSASSVTIVD 310
Cdd:cd17479   82 --------------------------------------------------------IFLLVLLVIIIWELLSAPLEKVAD 105

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 311 TVTLQYLGKHR--DRYGLQRMWGSLGwgLAMLSVGIGidythieVLIDGKGCKPPEYRN-YQIVFIVFGVLMTMALIVAT 387
Cdd:cd17479  106 DSLYEYLDFVDatERYGKLKVWSALG--AAFGPCGIT-------LLVDNLDCFLPPKISrILLHFYTYGGFMILTFLLSF 176

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 388 QFrfrynhfknddskgkEVEIPQVERNNStesseetptttSHSQAFNFwdlikLLCSVQ---YGSVLFVawfMGFGYGFV 464
Cdd:cd17479  177 FY---------------PIPVPKKEEHSS-----------KVVKGLRL-----LGGDGRailYALTVFL---VGFVGSTV 222

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 465 FTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQG 544
Cdd:cd17479  223 QNFLFWLMQDKGGSELHMGLSIALALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHA 302

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187610244 545 VTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFA 618
Cdd:cd17479  303 FSNGALWWAVNSQVEFLASPGMERSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

73-622

4.56e-33

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 131.78 E-value: 4.56e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  73 VFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFV 152
Cdd:cd06174    3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGR-RPVLLLGLLLFALGALLFAFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 153 KPatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlqpqtge 232
Cdd:cd06174   82 PS------------------------------------------------------------------------------ 83

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 233 itnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqeveaiFLVILVVVIIGEFFSASSVTIVDTV 312
Cdd:cd06174   84 -------------------------------------------------------FWLLLLGRFLLGLGSGLIDPAVLAL 108

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 313 TLQYLGKHR--DRYGLQRMWGSLGWGLAMLSVGIGIDYThievlidgkgckppeyrnYQIVFIVFGVLMTMALIVATQFR 390
Cdd:cd06174  109 IADLFPERErgRALGLLQAFGSVGGILGPLLGGILASSL------------------GFGWRAVFLIAAALALLAAILLL 170

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 391 FRYNHFKNDDSKGKEVEipqvernnstesseetptttshSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYW 470
Cdd:cd06174  171 LVVPDPPESARAKNEEA----------------------SSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL 228

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 471 HLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIE-LIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHA 548
Cdd:cd06174  229 FLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLG 308

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187610244 549 AIWAACISYLSAAVPPELRTSAQGIlqglhLGLGRGCGAMIGGVLVNYFGAAAT-FRGIGMACLVILLLFALIQW 622
Cdd:cd06174  309 GLLPLSFALIAELFPPEIRGTAFGL-----LNTFGFLGGAIGPLLAGFLLAATFgLTGAFLVLAVLLLLAAILLL 378

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

76-620

8.39e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 92.25 E-value: 8.39e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFVkpa 155
Cdd:cd17325    6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGR-KRLLLLGLLLLAVSTLLFAFA--- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 156 tlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlqpqtgeitn 235
Cdd:cd17325      --------------------------------------------------------------------------------

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 236 rmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqeveAIFLVILVVVIIGEFFSASSVT-----IVD 310
Cdd:cd17325   82 --------------------------------------------------TSYWQLLLARFLQGLASAAVWPaamalIAD 111

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 311 TVTLQYLGKhrdRYGLqrMWGSLGWGlAMLSVGIGIdythieVLIDGKGckppeyrnYQIVFIVFGVLMTMALIVATQFR 390
Cdd:cd17325  112 IAPPEERGR---AMGI--FSSAIGLG-FLIGPLLGG------LLADALG--------YRAPFLVCAALALLALVLALLLL 171

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 391 frynhfknddskgkeveipqvernnstESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYW 470
Cdd:cd17325  172 ---------------------------PEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPL 224

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 471 HLEDLNGTTT-----LFGVcSVLSHVseLTAYFFShKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGV 545
Cdd:cd17325  225 YAAELGGLSPaqiglLFGA-QGLASA--LSQPPAG-KLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGL 300

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187610244 546 THAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 620
Cdd:cd17325  301 GLGLVFPATLALLADIVPPEGRGTAMGLFNTA-FSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374

AraJ

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

450-627

6.17e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 83.10 E-value: 6.17e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:COG2814   14 ALALGAFLsGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigM 608
Cdd:COG2814   94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLADLFGWRWVF----L 168

                        170
                 ....*....|....*....
gi 187610244 609 ACLVILLLFALIQWLAVPD 627
Cdd:COG2814  169 VNAVLALLALLLLLRLLPE 187

MFS_1

pfam07690

Major Facilitator Superfamily;

450-630

4.03e-16

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 80.54 E-value: 4.03e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  450 VLFVAWFMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGaaatFRGIGM 608
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLV-SAGFGLGAALGPLLGGLLASLFG----WRAAFL 155

                         170       180
                  ....*....|....*....|..
gi 187610244  609 ACLVILLLFALIQWLAVPDEEE 630
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPES 177

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

450-630

2.16e-13

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.61 E-value: 2.16e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 529
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 530 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigMA 609
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSA-IGLGFLIGPLLGGLLADALGYRAPF----LV 155

                        170       180
                 ....*....|....*....|.
gi 187610244 610 CLVILLLFALIQWLAVPDEEE 630
Cdd:cd17325  156 CAALALLALVLALLLLPEPRP 176

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

450-649

2.88e-12

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 69.12 E-value: 2.88e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 529
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 530 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRtsaqGILQGLHlGLGRGCGAMIGGVLVNYFG-AAATFRGIGM 608
Cdd:cd17477   81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENR----GRVLGLY-STVLGLGFALGPLLLALVGtAGALPFLIAA 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 187610244 609 ACLVILLLFALIQWLAVPDEEEDKTMLAERIpVPSSPVPIA 649
Cdd:cd17477  156 VLLLLALVPLLLTRRAAPEIEEAESISLRRL-LRIAPLALL 195

AraJ

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

287-583

1.35e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 66.92 E-value: 1.35e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 287 IFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKhrdRYGLQRMWGSLGWGLAMLSVGIGIDYThievlidgkgckppeyr 366
Cdd:COG2814  102 LAARFLQGLGAGALFPAALALIADLVPPERRGR---ALGLLGAGLGLGPALGPLLGGLLADLF----------------- 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 367 NYQIVFIVFGVLMTMALIVATQFrfrynhfknddskgkeveIPqvernnstesseETPTTTSHSQAFNFWDLIKllcSVQ 446
Cdd:COG2814  162 GWRWVFLVNAVLALLALLLLLRL------------------LP------------ESRPAARARLRGSLRELLR---RPR 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 447 YGSVLFVAWFMGFGYGFVFTFLYWHLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYI 525
Cdd:COG2814  209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 187610244 526 YISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGR 583
Cdd:COG2814  289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

421-620

2.96e-11

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 66.05 E-value: 2.96e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 421 EETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTT-----LFGVCSVLShvsELT 495
Cdd:cd17474  174 PEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPiiiglLFAGWSVLL---ALG 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 496 AYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQ 575
Cdd:cd17474  251 SLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYN 330

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 187610244 576 GLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 620
Cdd:cd17474  331 FV-RFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374

MFS_1

pfam07690

Major Facilitator Superfamily;

287-590

1.27e-10

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 63.59 E-value: 1.27e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  287 IFLVILVVVIIGeFFSASSVTIVDTVTLQYLGK-HRDR-YGLQRMWGSLGWGLAMLSVGIGIDYThievlidgkgckppe 364
Cdd:pfam07690  85 LWLLLVLRVLQG-LGAGALFPAALALIADWFPPeERGRaLGLVSAGFGLGAALGPLLGGLLASLF--------------- 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  365 yrNYQIVFIVFGVLMTMALIVAtqFRFRYNHFKNDDSKGKEVEIPQVErnnstesseetptttshsqafnfwdLIKLLCS 444
Cdd:pfam07690 149 --GWRAAFLILAILSLLAAVLL--LLPRPPPESKRPKPAEEARLSLIV-------------------------AWKALLR 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  445 VQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACN---T 521
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLilaA 279

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187610244  522 ARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQglhlgLGRGCGAMIG 590
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYN-----TAGSLGGALG 343

UhpC

Sugar phosphate permease [Carbohydrate transport and metabolism];

450-625

1.67e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 63.35 E-value: 1.67e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:COG2271   14 LLFLAYFLNYLDRSNLSVAAPPLqADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFRGIGM 608
Cdd:COG2271   94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGG-PLGGALAPPLLGWLLAAFGWRAAFLILGL 172

                        170
                 ....*....|....*..
gi 187610244 609 ACLVILLLFALIQWLAV 625
Cdd:COG2271  173 PGLLLALLRFWLLALAY 189

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

452-619

3.36e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 62.61 E-value: 3.36e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 452 FVAWFMGFGYGFVFTFLYWHLEDLNGTT-----TLFGVCSVLSHvseltayFFSHKLIELIGHIRVLYIGLACNTARYIY 526
Cdd:cd17489  201 LILFLASIAYGAISTFLPLYAAERGISNaglffTVYAIALLLSR-------PFSGKLSDRKGPKTVIIPGLLLLALGLLL 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 527 ISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGI 606
Cdd:cd17489  274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIF-FDLGIGLGGLLLGLVAELFGYRAMFLLA 352

                        170
                 ....*....|...
gi 187610244 607 GMACLVILLLFAL 619
Cdd:cd17489  353 AVVVLLALVLYIF 365

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

449-620

9.25e-10

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.07 E-value: 9.25e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 449 SVLFVawFMGFGYGFVFTFLYwhLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:cd17489    4 ANFFF--FLSFYLLLPVLPLY--AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGM 608
Cdd:cd17489   80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYY-GLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158

                        170
                 ....*....|..
gi 187610244 609 ACLVILLLFALI 620
Cdd:cd17489  159 LALLALLLVFLV 170

MFS_YxlH_like

cd17490

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...

457-616

1.09e-09

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 61.08 E-value: 1.09e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 457 MGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSE-LTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWT 535
Cdd:cd17490  207 QMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNaLASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 536 VLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILL 615
Cdd:cd17490  287 LYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIY-ALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAI 365


                 .
gi 187610244 616 L 616
Cdd:cd17490  366 L 366

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

450-651

1.35e-09

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 60.90 E-value: 1.35e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 529
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 530 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGlhlglGRGCGAMIGGVLVNYFGAA--ATFRGIG 607
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQA-----FGSVGGILGPLLGGILASSlgFGWRAVF 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 187610244 608 MACLVILLLFALIQWLAVPDEEEDKTMLAERIPVPSSPVPIATI 651
Cdd:cd06174  156 LIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRV 199

ProP

COG0477

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...

450-619

2.19e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.44 E-value: 2.19e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVcsVLShvseltAYFFSH--------KLIELIGHIRVLYIGLACN 520
Cdd:COG0477   18 ALALGTFLeGLDFTIVNVALPSIAADLGASSAQLGW--IVS------AYLLGRaiglllfgRLGDRYGRKRVLLIGLLLF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 521 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA 600
Cdd:COG0477   90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA-IGLGLALGPLLGGLLVAALGWR 168

                        170
                 ....*....|....*....
gi 187610244 601 ATFrGIGMACLVILLLFAL 619
Cdd:COG0477  169 WIF-LINAPLGLLALVLRL 186

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

450-620

2.47e-09

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.94 E-value: 2.47e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 529
Cdd:cd06173  214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 530 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMA 609
Cdd:cd06173  294 SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNAL-NSGAMPLGALLAGLLADALGLSAVFLLAGAL 372

                        170
                 ....*....|.
gi 187610244 610 CLVILLLFALI 620
Cdd:cd06173  373 LLLAALLLLLL 383

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

324-620

2.58e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 60.30 E-value: 2.58e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 324 YGLQRMWGSLGWGLAMLSVGIgidythievLIDGKGCKPPEyrNYQIVFIVFGVLMTMALIVAtqFRFRynhfknddskg 403
Cdd:COG2211  149 SSWRFAFAGLGGLLASVLPPP---------LVAAFGGDAAL--GYRLTALIFAVLGLLAFLLT--FFGT----------- 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 404 KEVEIPQVERnnstesseetptttshsqaFNFWDLIKLLCSV-QYGSVLFVAWFMGFGYGFVFT-FLYWHLEDLNGTTTL 481
Cdd:COG2211  205 KERPVPEEEK-------------------VSLKESLKALLKNrPFLLLLLAYLLFFLALALVAAlLLYYFKYVLGLSAAL 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 482 FGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYI--YISYLENAWTVLPMEVLQGVTHAAIWAACISYLS 559
Cdd:COG2211  266 VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLllFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLA 345

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187610244 560 AAVPP-ELRT--SAQGILQGLH---LGLGRGCGAMIGGVLVNYFG-------AAATFRGIGMACLVILLLFALI 620
Cdd:COG2211  346 DVVDYdEWKTgrRREGLYFGIFtfaIKLGQALAGALAGLLLALFGyvagaaqSPSALTGIRLLFFLLPAVLLLL 419

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

458-617

3.38e-09

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 59.51 E-value: 3.38e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 458 GFGYGFVFTFLYWHLEDLNGT----------TTLFGVCSVLShvseltAYFFShKLIELIGHIRVLYIGLACNTARYIYI 527
Cdd:cd17330    9 ALGFGIVFPVLPFYVREFNKLgasgyyvgllQSSYSLGQFLA------SPLWG-RLSDRYGRKPVLLLSLAGSAVSYVLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 528 SYLENAWTVLPMEVLQGVTHAAIwAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGAAATF---R 604
Cdd:cd17330   82 GLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGII-SAAFGLGFILGPALGGFLSTPYGYALPFlvaA 159

                        170
                 ....*....|...
gi 187610244 605 GIGMACLVILLLF 617
Cdd:cd17330  160 ALALLNLVLVLFF 172

NarK

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

450-619

6.64e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 58.74 E-value: 6.64e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFmgfgyGFVFTFLYWHL---------EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACN 520
Cdd:COG2223    6 VLLLATL-----AFFLAFGVWYLwsvlapplaEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 521 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA 600
Cdd:COG2223   81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGG-GNLGAAVAAFLAPLLIAAFGWR 159

                        170
                 ....*....|....*....
gi 187610244 601 ATFRGIGMACLVILLLFAL 619
Cdd:COG2223  160 NAFLILGILLLVVAVLAWL 178

UhpC

Sugar phosphate permease [Carbohydrate transport and metabolism];

73-152

1.36e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 57.57 E-value: 1.36e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  73 VFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFkkG-KIVLLFSLLCWVLFNLGIGF 151
Cdd:COG2271   17 LAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRF--GrRRVLAIGLLLWGLATLLFGF 94


                 .
gi 187610244 152 V 152
Cdd:COG2271   95 A 95

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

68-157

2.00e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.22 E-value: 2.00e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  68 LLISKVFYFFFYSAYGSLYPLLPVYYkqLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNL 147
Cdd:COG2211  233 LLLAYLLFFLALALVAALLLYYFKYV--LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK-KKAFIIGLLLAALGLL 309

                         90
                 ....*....|
gi 187610244 148 GIGFVKPATL 157
Cdd:COG2211  310 LLFFLGPGNL 319

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

456-633

2.94e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 56.47 E-value: 2.94e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 456 FMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAW 534
Cdd:cd17329   10 LNRLGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 535 TVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFgaaatFRGIGMACLVIL 614
Cdd:cd17329   90 LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL-YWAINLGVAIGPLLGGLLLLYS-----FRLLFLAAAVLF 163

                        170
                 ....*....|....*....
gi 187610244 615 LLFALIQWLAVPDEEEDKT 633
Cdd:cd17329  164 LLAALVLLFLLPETRPKRR 182

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

450-620

5.81e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 55.69 E-value: 5.81e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFMGFGYGFVFTFL-YWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACnTARYIYIS 528
Cdd:cd17316  182 LILLWFFISFGYYGLTTFLpTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL-SGILALPL 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 529 YL---ENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAqgilqglhLGLGRGCGAMIGGVLVNYFGAAATFRG 605
Cdd:cd17316  261 FYllsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATG--------VGLSYNLGRLGGGGAPPLIALLLASTG 332

                        170
                 ....*....|....*
gi 187610244 606 IGMACLVILLLFALI 620
Cdd:cd17316  333 GTGVPALILALLAIV 347

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

502-618

7.80e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 55.26 E-value: 7.80e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 502 KLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGL 581
Cdd:cd17321   53 RLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLW-GAVVGI 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 187610244 582 GRGCGAMIGGVLVNYFGAAATF--------------RGIGMACLVILLLFA 618
Cdd:cd17321  132 GAALGPLLGGLLLELFGWRWIFlinvpiglvalllaRTFSGAVLAAFLLGA 182

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

450-617

7.91e-08

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 55.24 E-value: 7.91e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFMGFGYgFVFTFLYWHLEDLNGTTTLFGVCSVLSH-VSELTAYFFSHkLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:cd17370  205 YLLAVALFALGN-FSFAFLILRAQELGLSAALIPLLYALFNlVYALAAYPAGR-LSDRIGRKKLLILGYLSLALAYLGFA 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGIlqglhLGLGRGCGAMIG----GVLVNYFGAAATFR 604
Cdd:cd17370  283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGL-----FNTVVGIGWLLAsliaGYLWDLISPSAAFL 357

                        170
                 ....*....|....
gi 187610244 605 -GIGMACLVILLLF 617
Cdd:cd17370  358 fSAVLALIALLLLL 371

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

287-621

1.97e-07

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 54.16 E-value: 1.97e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 287 IFLVILVVVIIGE--FFSASSVTIVDTVTlqylGKHRDR-YGLQRMWGSLGWGLAMLSVGIGIDYthievlidgkgckpp 363
Cdd:cd17329   90 LFAIALVLTGFGGglFEPASEAMIADVTT----PENRTRaFSLLYWAINLGVAIGPLLGGLLLLY--------------- 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 364 eyrNYQIVFIVFGVLMTM-ALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNnstesseetptttshsQAFnfwdlikll 442
Cdd:cd17329  151 ---SFRLLFLAAAVLFLLaALVLLFLLPETRPKRRAAEKTEILRGYKIVLRD----------------RAF--------- 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 443 csvqygsVLFVAWFMG--FGYGFVFTFLYWHLEDLNGTTT-----LFGVCSVLShvseLTAYFFSHKLIELIGHIRVLYI 515
Cdd:cd17329  203 -------LLFLLASFLisLIYFQLESTLPVYVVEILGLGEsllglLLALNALLI----VLLQFPVARLVERFRLRKILMI 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 516 GLACNTARYIyISYLENAWTVLPM--------EVLqGVTHAAIWAACISylsaavPPELRTSAQGiLQGLHLGLGRGCGA 587
Cdd:cd17329  272 GILLFAIGFA-VLAFANTLAVLILamivltlgEML-VFPAVQTLVAALA------PPDKRGSYMG-FYALAWGLGRAIGP 342

                        330       340       350
                 ....*....|....*....|....*....|....
gi 187610244 588 MIGGVLVNYFGAAATFRGIGMACLVILLLFALIQ 621
Cdd:cd17329  343 LVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

450-621

2.59e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 53.73 E-value: 2.59e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLF--GVCSVLSHVSELTAYFFShKLIELIGHIRVLYIGLACNTARYIYI 527
Cdd:cd17473  202 IYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALigLALAIASLAGAIGALLFG-RLKRRLGKRRLLAIGFALMALGFLLL 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 528 SYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVN-YFGAAATFRGI 606
Cdd:cd17473  281 ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA-FFLGQFLSPLVLGPLVNlTGGLSGAFLIL 359

                        170
                 ....*....|....*
gi 187610244 607 GMACLVILLLFALIQ 621
Cdd:cd17473  360 GVLALVLAIVLLLLR 374

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

65-157

2.70e-07

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 53.58 E-value: 2.70e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  65 NNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGM-SPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWV 143
Cdd:cd06174  202 NPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMA 281

                         90
                 ....*....|....
gi 187610244 144 LFNLGIGFVKPATL 157
Cdd:cd06174  282 LGLALLLLAPSLLL 295

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

503-627

4.18e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.94 E-value: 4.18e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 503 LIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQ-GLHLG- 580
Cdd:cd17324   57 LSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFsGLTLGl 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 187610244 581 -LGRgcgaMIGGVLVNYFGAAATFRGIGmaclVILLLFALIQWLAVPD 627
Cdd:cd17324  137 vLGR----PLGGLLGQLLGWRAAFLAIA----VLALLAALLLWRLLPS 176

MFS_NHS

cd06177

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ...

488-619

6.22e-07

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 52.63 E-value: 6.22e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 488 LSHVSE----LTAYFFSHKLieliGHIRVLYIGLACNTARYIYISYL---ENAWTVLPMEVLQGVTHAAIWAACISYLSA 560
Cdd:cd06177  242 LGQISEilfmLAIPFFLKRL----GIKKVMLIGMLAWVLRFGLFAYGdpsPGVWMLVLSIILHGVCYDFFFVTGYIYVDK 317

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 187610244 561 AVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAAT---FRGI-----GMAcLVILLLFAL 619
Cdd:cd06177  318 KAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTTVEGtkdWQTIwlvpaIYA-LVLAILFAL 383

NarK

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

68-157

6.47e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.58 E-value: 6.47e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  68 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFkKGKIVLLFSLLCWVLFNL 147
Cdd:COG2223    7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF-GPRRVLLIGLLLLGIGLL 85

                         90
                 ....*....|
gi 187610244 148 GIGFVKPATL 157
Cdd:COG2223   86 LLALAVSYWL 95

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

31-152

7.12e-07

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.19 E-value: 7.12e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  31 REPEPPSNETPSSTETSAIPEEEIdwiekhcvKINNDLLISKVFYFFFYSAYGSLYPLLPVYYKQL-GMSPSQSGLLVGI 109
Cdd:cd17325  172 PEPRPPPNKRAVSAARLRSGLRLL--------LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGA 243

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 187610244 110 RYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFV 152
Cdd:cd17325  244 QGLASALSQPPAGKLSDRIGR-KPLILIGLLLSAVALLLLPLA 285

UhpC

Sugar phosphate permease [Carbohydrate transport and metabolism];

450-620

7.28e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.18 E-value: 7.28e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWF-MGFGYGFVFTFLYWHLEDLNG--------TTTLFGVCSVlshVSELTAYFFSHKLIEliGHIRVLYIGLACN 520
Cdd:COG2271  184 LLALAYFlVYFALYGFLTWLPTYLVEVRGlslaqaglLLSLPFLAGI---VGSLLGGWLSDRLGR--RRKLVLAIGLLLA 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 521 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLgLGRGCGAMIGGVLVNYFGAA 600
Cdd:COG2271  259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF-LGGALGPLLVGYLLDATGYQ 337

                        170       180
                 ....*....|....*....|
gi 187610244 601 ATFrGIGMACLVILLLFALI 620
Cdd:COG2271  338 AAF-LLLAALALLAALLALL 356

MFS_MMR_MDR_like

cd17504

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...

494-620

1.17e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 51.42 E-value: 1.17e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 494 LTAYF--------FSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIwAACISYLSAAVPPE 565
Cdd:cd17504   37 LTAYLlvgavstpILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPE 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 187610244 566 LRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 620
Cdd:cd17504  116 RVPVAQGILSAT-FGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI 169

AraJ

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

73-152

1.25e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.13 E-value: 1.25e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  73 VFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIV---LLFSLLCWVLFNLG 148
Cdd:COG2814  214 LLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLligLLLLALGLLLLALA 293


                 ....
gi 187610244 149 IGFV 152
Cdd:COG2814  294 GSLW 297

UhpC

Sugar phosphate permease [Carbohydrate transport and metabolism];

73-157

1.46e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 1.46e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  73 VFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRF-KKGKIVLLFSLLCWVLFNLGIG 150
Cdd:COG2271  187 LAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLA 266


                 ....*..
gi 187610244 151 FVKPATL 157
Cdd:COG2271  267 LLPSPAL 273

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

64-152

1.50e-06

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.06 E-value: 1.50e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  64 INNDLLISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCW 142
Cdd:cd17316  175 LRRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR-KKTLVIGLILS 253

                         90
                 ....*....|
gi 187610244 143 VLFNLGIGFV 152
Cdd:cd17316  254 GILALPLFYL 263

MFS_1

pfam07690

Major Facilitator Superfamily;

36-156

1.58e-06

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.88 E-value: 1.58e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244   36 PSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFyFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEF 115
Cdd:pfam07690 171 PRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGA 249

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 187610244  116 CSAPFWGVVADRFKKGKIVLLFSLLCwVLFNLGIGFVKPAT 156
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALLLL-ILAALGLLLLSLTL 289

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

73-157

1.76e-06

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.03 E-value: 1.76e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  73 VFYFFFYSA-YGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGF 151
Cdd:COG2807  221 TLFFGLQSLlYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLL 300


                 ....*.
gi 187610244 152 VkPATL 157
Cdd:COG2807  301 A-PGSL 305

MFS_unc93_like

cd17338

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ...

460-617

5.42e-06

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340896 [Multi-domain] Cd Length: 388 Bit Score: 49.65 E-value: 5.42e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 460 GYGFVFTFLYWHL---------EDLNGTTTLFGVcsvlsHVSELTAYFFSHKLIELIGHIRVLYIGLaCNTARYIYISYL 530
Cdd:cd17338    5 SFGFLLIFLAYSAlqnlqtslhENGLGSISLGIL-----YSSFAVSSFIAPLLVKLLGEKITLVLGG-LGYAIFIASNIF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 531 ENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA-------ATF 603
Cdd:cd17338   79 PIWGTLVPASIILGFAAAILWTAQGTYITRISDESNIGRNFGIFWSI-FQLSQVFGNLISLALLNHSKGSsgttilfIVF 157

                        170
                 ....*....|....
gi 187610244 604 RGIgMACLVILLLF 617
Cdd:cd17338  158 MAI-MLVGIILLFF 170

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

76-152

6.39e-06

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.15 E-value: 6.39e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 187610244  76 FFFYSAYGSLYPLLPVY-YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFV 152
Cdd:cd17329    9 FLNRLGFFMVWPFMAIYlHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR-KPVMLAGLLLRALGFALLGFA 85

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

450-620

6.94e-06

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 49.11 E-value: 6.94e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFMGFGY-GFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAY-FFSHKLIELIGHIRVLYIGLACNTARYIYI 527
Cdd:cd17330  179 LLLVYFLIALAFaGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 528 SYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFrGIG 607
Cdd:cd17330  259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQ-SLARIIGPLLAGPLYSFLGPGVPF-LLA 336

                        170
                 ....*....|...
gi 187610244 608 MACLVILLLFALI 620
Cdd:cd17330  337 AGLLLIALFLLSL 349

NarK

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

73-145

1.55e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 47.95 E-value: 1.55e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187610244  73 VFYFFFYSAYGSLYPLLPVYYK-QLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLF 145
Cdd:COG2223  212 LLYFGTFGSFIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL 285

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

452-639

3.10e-05

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.22 E-value: 3.10e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 452 FVAWFMG-----FGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLyigLACNTAR--- 523
Cdd:cd06173    1 FRLLWLAqllsaLGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLL---ILADLLRall 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 524 -----YIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFG 598
Cdd:cd06173   78 aavlaLLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLA-TQLARIIGPALGGLLVALLG 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 187610244 599 AAATFRGIGMACLVILLLFALIQWLAVPDEEEDKTMLAERI 639
Cdd:cd06173  157 PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDL 197

MFS_MdtG_MDR_like

cd17391

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...

76-152

3.20e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.87 E-value: 3.20e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIG 150
Cdd:cd17391    6 FFTGIGFSLIAPFLPLYIEQLGVTSGGlvelwSGLAFSSTFLVSAIFSPIWGRLADRYGR-KPMLLRASLGMAIVIGLMA 84


                 ..
gi 187610244 151 FV 152
Cdd:cd17391   85 FV 86

Nuc_H_symport

pfam03825

Nucleoside H+ symporter;

488-619

3.83e-05

Nucleoside H+ symporter;

Pssm-ID: 461066 [Multi-domain] Cd Length: 399 Bit Score: 46.69 E-value: 3.83e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  488 LSHVSE----LTAYFFSHKLieliGHIRVLYIGLACNTARYIYISYLEN------AWTVLPMeVLQGVTHAAIWAACISY 557
Cdd:pfam03825 251 LGQISEilfmLTLPFFLKRF----GIKNVMLIGIVAWALRFAFFAYGADptpfgtALLLLSM-IVHGVAYDFFNITGYIF 325

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187610244  558 LSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR-------GIGMAcLVILLLFAL 619
Cdd:pfam03825 326 VDKEVPPAIRASAQGLFLLMTNGFGCILGSILSGMVVEMFTQDGITDwqtvwlvFAGMA-LVLAVLFMA 393

MFS_YajR_like

cd17472

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...

507-633

5.05e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 46.44 E-value: 5.05e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 507 IGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVthAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCG 586
Cdd:cd17472   59 IGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALI-GASIGIAFAIS 135

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 187610244 587 AMIGGVLVNYFGAAATFrgIGMACLVILLLFalIQWLAVPDEEEDKT 633
Cdd:cd17472  136 MVLGPLLAAHLGVSGLF--LITAILSLVSLL--ILLFFVPDPPKIVQ 178

PRK09874

multidrug efflux MFS transporter MdtG;

76-140

6.69e-05

multidrug efflux MFS transporter MdtG;

Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 46.07 E-value: 6.69e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADRfKKGKIVLLFSLL 140
Cdd:PRK09874  24 FLTGAAFSLVMPFLPLYVEQLGVTGHSalnmwSGLVFSITFLFSAIASPFWGGLADR-KGRKIMLLRSAL 92

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

292-620

6.94e-05

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.00 E-value: 6.94e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 292 LVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRM-WGSLGWGL-AMLSVGIGIdythieVLIDGKGckPPEYRnyq 369
Cdd:COG0738   96 YPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLnLLHAFFSLgALLGPLLGG------LLILLGL--SLSWH--- 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 370 IVFIVFGVLMTMALIVATQFRFrynhfknddskgkeveiPQVErnnsTESSEETPTTTSHSQAFNFwdlikllcsvqygS 449
Cdd:COG0738  165 LPYLILAVLLLLLALLFLRSKL-----------------PEIE----EEEEEAAGSAASLKSLLKN-------------P 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFMGFGYGFV----FTFLYWHLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARY 524
Cdd:COG0738  211 RLLLGGLAIFLYVGAegaiGDWLPLYLKDVLGlSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 525 IYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPelRTSAQGilqGLHLGLGrGCGAMIG----GVLVNYFGAA 600
Cdd:COG0738  291 LLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGK--RTAAAV---SAVLIMG-IVGGAIGppliGFLADAFGLR 364

                        330       340
                 ....*....|....*....|
gi 187610244 601 ATFrGIGMACLVILLLFALI 620
Cdd:COG0738  365 AAF-LVPLVCYLLILLLALA 383

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

450-618

7.02e-05

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.00 E-value: 7.02e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 450 VLFVAWFMGFGYGF-VFTFLYWHLEDLNGTTT--------LFGVCSVLShvseltAYFFShKLIELIGHIRVLYIGLACN 520
Cdd:cd17324  202 LAYLITFLLFGGFFaLYTYLAPFLTDVPGFSSsaiiglllLFGVAGVVG------SPLAG-RLADRGGRRALLIALLLLA 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 521 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPpelrtSAQGILQGLHLG---LGRGCGAMIGGVLVNYF 597
Cdd:cd17324  275 AALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-----EARGLASSLYLAaynLGGALGAALGGLVLDHG 349

                        170       180
                 ....*....|....*....|.
gi 187610244 598 GAAATFRGIGMACLVILLLFA 618
Cdd:cd17324  350 GWAGVGWVGAALLLLALLLAL 370

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

81-154

8.39e-05

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.65 E-value: 8.39e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 187610244  81 AYGSLYPLLPVY---YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFVKP 154
Cdd:cd17330   11 GFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGR-KPVLLLSLAGSAVSYVLLGLSRN 86

MFS_SLC46

cd17386

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...

514-619

8.60e-05

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 45.73 E-value: 8.60e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244 514 YIGLACNTARYIYISYLENAWTV---LPMEVLQGVT--HAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAM 588
Cdd:cd17386   67 LVGLLLSSLILVLIVYFTTVPSVwwfYLSAIPLALFggFTAFLSASFAYISDISSEKKRTYRMAILEVA-LGLGGFLGSL 145

                         90       100       110
                 ....*....|....*....|....*....|.
gi 187610244 589 IGGVLVNYFGAAATFrGIGMACLVILLLFAL 619
Cdd:cd17386  146 LSGHLFKALGYAWSF-SISAALLLIALLYIL 175

ProP

COG0477

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...

68-151

2.11e-04

Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.03 E-value: 2.11e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187610244  68 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIrYFIEFCS-APFWGVVADRFkkG-KIVLLFSLLCWVLF 145
Cdd:COG0477   16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSA-YLLGRAIgLLLFGRLGDRY--GrKRVLLIGLLLFGLA 92


                 ....*.
gi 187610244 146 NLGIGF 151
Cdd:COG0477   93 SLLCGL 98

NarK