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Conserved domains on  [gi|2493566|sp|Q60772|]
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RecName: Full=Cyclin-dependent kinase 4 inhibitor C; AltName: Full=Cyclin-dependent kinase 6 inhibitor; AltName: Full=p18-INK4c; AltName: Full=p18-INK6

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  33435370|17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-160 2.09e-27

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.88  E-value: 2.09e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQ 87
Cdd:COG0666  91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2493566   88 ALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTAcNVGHRNHKGDTAFDLARFYGRNEVISLMEANG 160
Cdd:COG0666 171 LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-160 2.09e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.88  E-value: 2.09e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQ 87
Cdd:COG0666  91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2493566   88 ALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTAcNVGHRNHKGDTAFDLARFYGRNEVISLMEANG 160
Cdd:COG0666 171 LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
Ank_2 pfam12796
Ankyrin repeats (3 copies);
46-127 5.02e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 5.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566     46 KLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFqADVNIEDNeGNLPLHLAAKEGHLPVVEFLMKH 125
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLLLEK 83


                  ..
gi 2493566    126 TA 127
Cdd:pfam12796  84 GA 85
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 45-168 1.00e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 1.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    45 MKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMK 124
Cdd:PHA02874 132 IKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLID 211

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 2493566   125 HTAcNVGHRNHKGDTAFDLARFYGRNeVISLMEANG------VGGATSLQ 168
Cdd:PHA02874 212 HGN-HIMNKCKNGFTPLHNAIIHNRS-AIELLINNAsindqdIDGSTPLH 259
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 104-158 3.79e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 36.91  E-value: 3.79e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 2493566  104 NLPLHLAAKEGHLPVVEFLMKHTACNVGHRNHKGDTAFDLARFYGRNEV-ISLMEA 158
Cdd:cd22192  18 ESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAaVVLMEA 73
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 102-127 4.10e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 4.10e-03
                           10        20
                   ....*....|....*....|....*.
gi 2493566     102 EGNLPLHLAAKEGHLPVVEFLMKHTA 127
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-160 2.09e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.88  E-value: 2.09e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQ 87
Cdd:COG0666  91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2493566   88 ALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTAcNVGHRNHKGDTAFDLARFYGRNEVISLMEANG 160
Cdd:COG0666 171 LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
7-160 2.29e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.79  E-value: 2.29e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    7 NELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTAL-QVMKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDT 85
Cdd:COG0666  56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLhAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2493566   86 VQALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTAcNVGHRNHKGDTAFDLARFYGRNEVISLMEANG 160
Cdd:COG0666 136 VKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVKLLLEAG 209
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-160 1.06e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.07  E-value: 1.06e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQ 87
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVK 203

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2493566   88 ALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTAcNVGHRNHKGDTAFDLARFYGRNEVISLMEANG 160
Cdd:COG0666 204 LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-160 5.26e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.15  E-value: 5.26e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQA 88
Cdd:COG0666  26 LAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKL 105

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2493566   89 LLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTAcNVGHRNHKGDTAFDLARFYGRNEVISLMEANG 160
Cdd:COG0666 106 LLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG 176
Ank_2 pfam12796
Ankyrin repeats (3 copies);
46-127 5.02e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 5.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566     46 KLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFqADVNIEDNeGNLPLHLAAKEGHLPVVEFLMKH 125
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLLLEK 83


                  ..
gi 2493566    126 TA 127
Cdd:pfam12796  84 GA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
74-155 2.83e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 2.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566     74 IHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTACNVghrNHKGDTAFDLARFYGRNEVI 153
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL---KDNGRTALHYAARSGHLEIV 77


                  ..
gi 2493566    154 SL 155
Cdd:pfam12796  78 KL 79
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 45-168 1.00e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 1.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    45 MKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMK 124
Cdd:PHA02874 132 IKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLID 211

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 2493566   125 HTAcNVGHRNHKGDTAFDLARFYGRNeVISLMEANG------VGGATSLQ 168
Cdd:PHA02874 212 HGN-HIMNKCKNGFTPLHNAIIHNRS-AIELLINNAsindqdIDGSTPLH 259
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 53-129 1.43e-12

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 64.53  E-value: 1.43e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2493566    53 ARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTACN 129
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCH 174
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 49-160 1.12e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.90  E-value: 1.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    49 NPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTA- 127
Cdd:PHA02874 103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAy 182

                         90       100       110
                 ....*....|....*....|....*....|...
gi 2493566   128 CNVghRNHKGDTAFDLARFYGRNEVISLMEANG 160
Cdd:PHA02874 183 ANV--KDNNGESPLHNAAEYGDYACIKLLIDHG 213
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-140 2.01e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 2.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQ 87
Cdd:COG0666 157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLaAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVK 236

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 2493566   88 ALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTACNVGHRNHKGDTA 140
Cdd:COG0666 237 LLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
12-100 1.82e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 1.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566     12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIArRLLLRGANPNLKDGtGFAVIHDAARAGFLDTVQALL 90
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLaAKNGHLEIV-KLLLEHADVNLKDN-GRTALHYAARSGHLEIVKLLL 81

                          90
                  ....*....|
gi 2493566     91 EFQADVNIED 100
Cdd:pfam12796  82 EKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
73-122 3.41e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.35  E-value: 3.41e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2493566     73 VIHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFL 122
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
41-160 6.56e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.42  E-value: 6.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566   41 ALQVMKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVE 120
Cdd:COG0666  25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 2493566  121 FLMKHTAcNVGHRNHKGDTAFDLARFYGRNEVISLMEANG 160
Cdd:COG0666 105 LLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAG 143
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 46-139 1.11e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.13  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    46 KLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDT------------------VQALLEFQADVNIEDNEGNLPL 107
Cdd:PHA03100 117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDVYGFTPL 196

                         90       100       110
                 ....*....|....*....|....*....|..
gi 2493566   108 HLAAKEGHLPVVEFLMkHTACNVGHRNHKGDT 139
Cdd:PHA03100 197 HYAVYNNNPEFVKYLL-DLGANPNLVNKYGDT 227
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 49-128 6.00e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.03  E-value: 6.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    49 NPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLAAkeGHL---PVVEFLMKH 125
Cdd:PHA02878 180 DQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYCkdyDILKLLLEH 257


                 ...
gi 2493566   126 TAC 128
Cdd:PHA02878 258 GVD 260
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 51-161 1.49e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.88  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    51 EIARRLLLRGANPNLKD-GTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTAcN 129
Cdd:PHA02878 148 EITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA-S 226

                         90       100       110
                 ....*....|....*....|....*....|...
gi 2493566   130 VGHRNHKGDTAFDLARFYGRN-EVISLMEANGV 161
Cdd:PHA02878 227 TDARDKCGNTPLHISVGYCKDyDILKLLLEHGV 259
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 7-140 2.59e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.22  E-value: 2.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566     7 NELASAAARGDLEQLTSLLQNNVNVNAQN-GFGRTALQV-MKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLD 84
Cdd:PHA02875  70 SELHDAVEEGDVKAVEELLDLGKFADDVFyKDGMTPLHLaTILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 2493566    85 TVQALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTAcNVGHRNHKGDTA 140
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA-NIDYFGKNGCVA 204
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 49-161 5.20e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.12  E-value: 5.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    49 NPEIARRLLLRGANPNLKDGTGFAVIHDAARAGF-----LDTVQALLEFQADVNIEDNEGNLPLHLAA--KEGHLPVVEF 121
Cdd:PHA03100  47 NIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEY 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 2493566   122 LMKHtACNVGHRNHKGDTAFDLARFYGRN--EVISLMEANGV 161
Cdd:PHA03100 127 LLDN-GANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGV 167
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 55-127 5.83e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.12  E-value: 5.83e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2493566    55 RLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTA 127
Cdd:PHA03100 177 YLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
Ank_5 pfam13857
Ankyrin repeats (many copies);
89-144 1.21e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.49  E-value: 1.21e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2493566     89 LLE-FQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHtACNVGHRNHKGDTAFDLA 144
Cdd:pfam13857   1 LLEhGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAY-GVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 37-144 2.10e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.56  E-value: 2.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    37 FGRTALQVMKLG---NPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDT--VQALLEFQADVNIEDNEGNLPLHLAA 111
Cdd:PHA03095 186 RFRSLLHHHLQSfkpRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRslVLPLLIAGISINARNRYGQTPLHYAA 265

                         90       100       110
                 ....*....|....*....|....*....|...
gi 2493566   112 KEGHLPVVEFLMKhTACNVGHRNHKGDTAFDLA 144
Cdd:PHA03095 266 VFNNPRACRRLIA-LGADINAVSSDGNTPLSLM 297
PHA03095 PHA03095
ankyrin-like protein; Provisional
 36-142 2.10e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.56  E-value: 2.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    36 GFGRTALQV-MKLGNP---EIARRLLLRGANPNLKDGTGFAVIHDAARAGF-LDTVQALLEFQADVNIEDNEGNLPLH-- 108
Cdd:PHA03095  45 EYGKTPLHLyLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHvy 124

                         90       100       110
                 ....*....|....*....|....*....|....
gi 2493566   109 LAAKEGHLPVVEFLMKHTAcNVGHRNHKGDTAFD 142
Cdd:PHA03095 125 LSGFNINPKVIRLLLRKGA-DVNALDLYGMTPLA 157
Ank_5 pfam13857
Ankyrin repeats (many copies);
59-110 2.92e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 2.92e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2493566     59 RGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLA 110
Cdd:pfam13857   5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 9-160 3.34e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.01  E-value: 3.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566     9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQ 87
Cdd:PLN03192 529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIaASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2493566    88 ALLEFqADVNIEDNEGNLpLHLAAKEGHLPVVEFLMKHtACNVGHRNHKGDTAFDLARFYGRNEVISLMEANG 160
Cdd:PLN03192 609 ILYHF-ASISDPHAAGDL-LCTAAKRNDLTAMKELLKQ-GLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNG 678
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 38-155 3.60e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.13  E-value: 3.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    38 GRTALQVM-KLG-NPEIARRLLLRGANPNLKDGTGFAVIHDAARAG-FLDTVQALLEFQADVNIEDNEGNLPLHLAAKEG 114
Cdd:PHA02876 307 GETPLYLMaKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRN 386

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 2493566   115 HLPVVEFLMKHTAcNVGHRNHKGDTAFDLArFYGRNEVISL 155
Cdd:PHA02876 387 NVVIINTLLDYGA-DIEALSQKIGTALHFA-LCGTNPYMSV 425
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 8-127 8.33e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 8.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566     8 ELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTV 86
Cdd:PHA02875   5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLaMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAV 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 2493566    87 QALLE---FQADVNIEDneGNLPLHLAAKEGHLPVVEFLMKHTA 127
Cdd:PHA02875  85 EELLDlgkFADDVFYKD--GMTPLHLATILKKLDIMKLLIARGA 126
Ank_4 pfam13637
Ankyrin repeats (many copies);
103-156 2.57e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 2.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2493566    103 GNLPLHLAAKEGHLPVVEFLMKHTAcNVGHRNHKGDTAFDLARFYGRNEVISLM 156
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 74-160 3.69e-04

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 38.70  E-value: 3.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    74 IHDAARAGFLDTVQA---LLEFQADVNIEDN-EGNLPLHLAAKEGHLPVVEFLMKHTACNVGHRNHKGDTAFDLArfYGR 149
Cdd:PHA02736  59 VHIVSNPDKADPQEKlklLMEWGADINGKERvFGNTPLHIAVYTQNYELATWLCNQPGVNMEILNYAFKTPYYVA--CER 136

                         90
                 ....*....|...
gi 2493566   150 NE--VISLMEANG 160
Cdd:PHA02736 137 HDakMMNILRAKG 149
PHA02743 PHA02743
Viral ankyrin protein; Provisional
 67-161 7.29e-04

Viral ankyrin protein; Provisional


Pssm-ID: 222925 [Multi-domain]  Cd Length: 166  Bit Score: 38.26  E-value: 7.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    67 DGTGFAVIHDAA---RAGFLDTVQALLEFQADVNI-EDNEGNLPLHLAAKEGHLPVVEFLMKHTACNVGHRNHKGDTAFD 142
Cdd:PHA02743  54 DHHGRQCTHMVAwydRANAVMKIELLVNMGADINArELGTGNTLLHIAASTKNYELAEWLCRQLGVNLGAINYQHETAYH 133

                         90
                 ....*....|....*....
gi 2493566   143 LARFYGRNEVISLMEANGV 161
Cdd:PHA02743 134 IAYKMRDRRMMEILRANGA 152
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 48-160 7.67e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 38.82  E-value: 7.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    48 GNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQA--DVNIEDNEGnlPLHLAAKEGHLPVVE-FLMK 124
Cdd:PHA02875  13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAipDVKYPDIES--ELHDAVEEGDVKAVEeLLDL 90

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 2493566   125 HTACN-VGHRnhKGDTAFDLARFYGRNEVISLMEANG 160
Cdd:PHA02875  91 GKFADdVFYK--DGMTPLHLATILKKLDIMKLLIARG 125
Ank_4 pfam13637
Ankyrin repeats (many copies);
38-90 8.06e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 8.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2493566     38 GRTALQV-MKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALL 90
Cdd:pfam13637   1 ELTALHAaAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 49-101 1.57e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 38.11  E-value: 1.57e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 2493566    49 NPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQADVNIEDN 101
Cdd:PHA03100 204 NPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
PHA02741 PHA02741
hypothetical protein; Provisional
 72-157 2.12e-03

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 36.94  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    72 AVIHDAARAgfLDTVQALLEFQADVNIEDN-EGNLPLHLAAKEGHLPVVEFLMKHTACNVGHRNHKGDTAFDLARFygrN 150
Cdd:PHA02741  68 AEKHEAQLA--AEIIDHLIELGADINAQEMlEGDTALHLAAHRRDHDLAEWLCCQPGIDLHFCNADNKSPFELAID---N 142


                 ....*..
gi 2493566   151 EVISLME 157
Cdd:PHA02741 143 EDVAMMQ 149
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 74-141 2.61e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 37.17  E-value: 2.61e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2493566    74 IHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLAAKE-GHLPVVEFLMKHTACNVGHRNHKGDTAF 141
Cdd:PHA02878  41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEpNKLGMKEMIRSINKCSVFYTLVAIKDAF 109
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 104-158 3.79e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 36.91  E-value: 3.79e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 2493566  104 NLPLHLAAKEGHLPVVEFLMKHTACNVGHRNHKGDTAFDLARFYGRNEV-ISLMEA 158
Cdd:cd22192  18 ESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAaVVLMEA 73
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 102-127 4.10e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 4.10e-03
                           10        20
                   ....*....|....*....|....*.
gi 2493566     102 EGNLPLHLAAKEGHLPVVEFLMKHTA 127
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 37-113 4.58e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 36.78  E-value: 4.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2493566    37 FGRTALQ--VMKLGNPEIARRLLLRGANPNLKDGT-GFAVIHDAARAGflDTVQALLEFQADVNIEDNEGNLPLHLAAKE 113
Cdd:PHA02878 233 CGNTPLHisVGYCKDYDILKLLLEHGVDVNAKSYIlGLTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPLSSAVKQ 310
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 38-67 5.75e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.03  E-value: 5.75e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2493566     38 GRTALQ--VMKLGNPEIARRLLLRGANPNLKD 67
Cdd:pfam00023   2 GNTPLHlaAGRRGNLEIVKLLLSKGADVNARD 33
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 52-98 6.66e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 36.19  E-value: 6.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 2493566    52 IARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQADVNI 98
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNI 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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