|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00973 |
PRK00973 |
glucose-6-phosphate isomerase; Provisional |
16-419 |
1.52e-131 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 179193 [Multi-domain] Cd Length: 446 Bit Score: 386.27 E-value: 1.52e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 16 GVERATLDDLDEQVAVAHERIEQGRNKGEFGYasLNLLEATDAETIHDAVAPVADAESVITVGIGGSALGAKTITEAL-- 93
Cdd:PRK00973 18 GISIEDIESVKEKITSAVENLMEKEPNGELGF--LELPYDRSLDSYEELKEWSKNFDNVVVLGIGGSALGNLALHYALnp 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 94 --------AEDPGSHV-VLDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLANFLVVREAYEDRGVDWTERIVVTTG 164
Cdd:PRK00973 96 lnwnelskEERNGPRVfVLDNVDPEKTASILDVIDLEKTLFNVISKSGNTAETLANYLIIRGILEKLGLDPKKHLVFTTD 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 165 -ESGPLRALADQHDLPTLPVPEGVPGRFSALSAVGLVPPAILGIDIEGLLAGGQQAADDLA-PSLYDSPAYAYGAMAYAL 242
Cdd:PRK00973 176 pEKGKLKKIAEKEGYRTLEIPENVGGRFSVLTPVGLAPAAALGIDIEELLEGAKEMDKICEkEDIFKNPALLNALIHYLY 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 243 EEAGATVNAVMPYAERLESFGEWFAQLWAESLGKDGRGQTPARALGATDQHSQLQLYRAGHRDKVVTFVRPRE-RADVSI 321
Cdd:PRK00973 256 YNRGKNISVMMPYSERLKYFGDWYRQLWAESLGKKGVGQTPVKALGATDQHSQLQLYMEGPKDKIITFLKVEKyRRDVEI 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 322 P--DPDHEDLSYLAGTDLGGLIDAEYEATVASLPAADRPALEVEIDRLDAESVGELLYAMEAACVLVGELADVETFTQPA 399
Cdd:PRK00973 336 PyeYEDIEELSYLGGHKLSELINSEQKGTEIALTENGRPNVKITLDELNEYTVGQLFYMYEMQTAFMGELLNINAFDQPG 415
|
410 420
....*....|....*....|
gi 81170495 400 VEWGKNATRALIRGEATDET 419
Cdd:PRK00973 416 VELGKKITYALLGRSGYEEE 435
|
|
| Pgi |
COG0166 |
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate ... |
1-423 |
8.54e-130 |
|
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate isomerase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439936 Cd Length: 484 Bit Score: 383.34 E-value: 8.54e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 1 MHVDIGAALASAAdpgvERATLDDLDEQVAvAHERIEQGR--NKGE---FGYASLNLLEATDA---------ETIHDAVA 66
Cdd:COG0166 23 LLLDYSKNRITDE----TLELLLELAEEEE-AREALFAGEkiNPTEgraVLHGALRLPEAGEDvmpevreelARIKAFAE 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 67 PV---ADAESVITVGIGGSALGAKTITEALAEDPGSHV---VLDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLAN 140
Cdd:COG0166 98 KVrtgKRITDVVNIGIGGSDLGPRAVIEALKPYFRDGPrvhFVSNVDPDYLAELLAGLDPETTLFIVISKSGTTQETLTN 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 141 FLVVREAYEDRGV-DWTERIVVTTGESGPLRALADQHDLPTLPVPEGVPGRFSALSAVGLVPPAILGIDIEGLLAGGQQA 219
Cdd:COG0166 178 ARVAREWLEKAGGeDAAKHFVAVTDNAGALRAFGIDEGYNTFPFPDWVGGRYSVLSAVGLLPAAAIGIDFEELLAGAHAM 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 220 ADDLA-PSLYDSPAYAYGAMAYALEEA-GATVNAVMPYAERLESFGEWFAQLWAESLGKD--------GRGQTPARALGA 289
Cdd:COG0166 258 DEHFRtAPLEENPPVLLALLGIWYRNFkGAETEAVLPYDQRLERFPAWLQQLWMESNGKSvdrdgnpvGYGTGPVGEPGT 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 290 TDQHSQLQLYRAGHRDKVVTFVRPRERADvSIPD---PDHEDLSYLAGTDLGGLIDAEYEATVASLPAADRPALEVEIDR 366
Cdd:COG0166 338 TDQHSFGQLLHQGTRDIPVTFIAVAEPHH-DIPDlllANLQGLALLAGKTLDEVLALAAEATPHALFPGNRPSNTILLPK 416
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 81170495 367 LDAESVGELLYAMEAACVLVGELADVETFTQPAVEWGKNATRALIRGEATDETAVID 423
Cdd:COG0166 417 LTPYTLGALIALYEHAVFVQGVLWGINPFDQPGVELGKKLAFALLGKLGGEEAAAGD 473
|
|
| PGI_Meth |
NF040629 |
glucose-6-phosphate isomerase; |
41-401 |
4.86e-65 |
|
glucose-6-phosphate isomerase;
Pssm-ID: 468601 Cd Length: 396 Bit Score: 213.97 E-value: 4.86e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 41 NKGEFGYASLNLLEATDA------ETIH----DAVAPVADAESVITVGIGGSALGAKTITEALAEDPGSHVVLDNVDPEH 110
Cdd:NF040629 21 NKVDFTNAYSNLMEKLDNgvvgfrDVIYdenlDKYKSLNGYKNVVVVGMGGSILGTMAIYYAISPFNNNAYFIDNSDPEK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 111 VRRTLDGLSLADTAINVVSRSGTTAETLANFLVVREAYEDRGVDWTERIVVTTGesGPLRALADQHDLPTLPVPEGVPGR 190
Cdd:NF040629 101 TLSILKKVDLNESIIYIISKSGNTLETLVNYYLIKKRIEKLNSFKGKIVFITNG--GKLKREAEKNNYEIYSIPENVPGR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 191 FSALSAVGLVPPAILGIDIEGLLAGGQQAaDDLAPS--LYDSPAYAYGAMAYALEEAGATVNAVMPYAERLESFGEWFAQ 268
Cdd:NF040629 179 FSVFTAVGLAPLYSLGIDISKILEGAREM-DKLCQNedILKNPALLNGVIHYLYDKKGKDISVIMSYIESLKYFGEWYKQ 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 269 LWAESLGKDGRGQTPARALGATDQHSQLQLYRAGHRDKVVTFVRPRE-RADVSI--PDPDHEDLSylagTDLGGLIDAEY 345
Cdd:NF040629 258 LIGESLGKNGNGITPLLSIGAKDQHSLLQLYMDGKKDKIITFITTKKyRLDEEIvfEDINDEEIS----CMLSDIIKCEQ 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 81170495 346 EATVASLPAADRPALEVEIDRLDAESVGELLYAMEAACVLVGELADVETFTQPAVE 401
Cdd:NF040629 334 KATEIALTNNGVPNVRITLDEINEMTMGALLYMYEMQVGFMGELYNINAYNQPAVE 389
|
|
| SIS_PGI_2 |
cd05016 |
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ... |
249-410 |
1.96e-53 |
|
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.
Pssm-ID: 240147 Cd Length: 164 Bit Score: 175.87 E-value: 1.96e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 249 VNAVMPYAERLESFGEWFAQLWAESLGKDGR--------GQTPARALGATDQHSQLQLYRAGHRDKVVTFVRPReradvs 320
Cdd:cd05016 2 THALLPYSQRLERFPAWLQQLDMESNGKSVTrdgedyptGPIPWGAPGTNDQHSFFQLIHQGTKDKPVDFIAVK------ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 321 ipDPDHEDLSYLAGTDLGGLIDAEYEATVASLPA-ADRPALEVEIDRLDAESVGELLYAMEAACVLVGELADVETFTQPA 399
Cdd:cd05016 76 --KPQNDVLDYLAGKTLHDLLLANCLATREALMFpGGRPSNTIVLPELTPYTLGALLALYEHKTAVQGALLGINPFDQPG 153
|
170
....*....|.
gi 81170495 400 VEWGKNATRAL 410
Cdd:cd05016 154 VELGKKLAKKI 164
|
|
| PGI |
pfam00342 |
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of ... |
74-404 |
2.25e-23 |
|
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.
Pssm-ID: 395271 Cd Length: 487 Bit Score: 102.17 E-value: 2.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 74 VITVGIGGSALGAKTITEALAEDPGSHV---VLDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLANFLVVREAYED 150
Cdd:pfam00342 99 VVNIGIGGSDLGPVMVTEALKPYSGRDLdvhFVSNVDGTHIAEVLKKLNPETTLFIVASKTFTTAETMTNAESAKEWLLK 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 151 RGVD---WTERIVVTTGESGPLRALA-DQHDLptLPVPEGVPGRFSALSAVGLvpPAILGIDIEG---LLAGGqqAADD- 222
Cdd:pfam00342 179 ALKDdsaVAKHFIALSTNAEKVEEFGiDTKNM--FEFWDWVGGRYSLWSAIGL--PIALSIGFENfqqLLEGA--HAMDk 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 223 ---LAPSLYDSPAYAYGAMAYALEEAGATVNAVMPYAERLESFGEWFAQLWAESLGK--DGRGQTPARALG-------AT 290
Cdd:pfam00342 253 hflSAPPEKNIPVLLALLGVWYNNFFGAQTHAILPYDQYLHRFPAYLQQLDMESNGKyvTRDGVLVDHQTGpiifgepGT 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 291 D-QHSQLQLYRAGHRDKVVTFVRPRERADVSIPDPDHEDLS-YLAGTDL------GGLIDAEYEATV--ASLPA----AD 356
Cdd:pfam00342 333 NgQHAFYQLIHQGTRLIPCDFIGAVQSQNPENGDHHKILLSnFFAQTEAlmvgksPEEVRKELAAADveHLIPHktftGN 412
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 81170495 357 RPALEVEIDRLDAESVGELLYAMEAACVLVGELADVETFTQPAVEWGK 404
Cdd:pfam00342 413 RPSNSILVQKLTPATLGALIAMYEHKIFVQGAIWGINSFDQWGVELGK 460
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00973 |
PRK00973 |
glucose-6-phosphate isomerase; Provisional |
16-419 |
1.52e-131 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 179193 [Multi-domain] Cd Length: 446 Bit Score: 386.27 E-value: 1.52e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 16 GVERATLDDLDEQVAVAHERIEQGRNKGEFGYasLNLLEATDAETIHDAVAPVADAESVITVGIGGSALGAKTITEAL-- 93
Cdd:PRK00973 18 GISIEDIESVKEKITSAVENLMEKEPNGELGF--LELPYDRSLDSYEELKEWSKNFDNVVVLGIGGSALGNLALHYALnp 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 94 --------AEDPGSHV-VLDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLANFLVVREAYEDRGVDWTERIVVTTG 164
Cdd:PRK00973 96 lnwnelskEERNGPRVfVLDNVDPEKTASILDVIDLEKTLFNVISKSGNTAETLANYLIIRGILEKLGLDPKKHLVFTTD 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 165 -ESGPLRALADQHDLPTLPVPEGVPGRFSALSAVGLVPPAILGIDIEGLLAGGQQAADDLA-PSLYDSPAYAYGAMAYAL 242
Cdd:PRK00973 176 pEKGKLKKIAEKEGYRTLEIPENVGGRFSVLTPVGLAPAAALGIDIEELLEGAKEMDKICEkEDIFKNPALLNALIHYLY 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 243 EEAGATVNAVMPYAERLESFGEWFAQLWAESLGKDGRGQTPARALGATDQHSQLQLYRAGHRDKVVTFVRPRE-RADVSI 321
Cdd:PRK00973 256 YNRGKNISVMMPYSERLKYFGDWYRQLWAESLGKKGVGQTPVKALGATDQHSQLQLYMEGPKDKIITFLKVEKyRRDVEI 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 322 P--DPDHEDLSYLAGTDLGGLIDAEYEATVASLPAADRPALEVEIDRLDAESVGELLYAMEAACVLVGELADVETFTQPA 399
Cdd:PRK00973 336 PyeYEDIEELSYLGGHKLSELINSEQKGTEIALTENGRPNVKITLDELNEYTVGQLFYMYEMQTAFMGELLNINAFDQPG 415
|
410 420
....*....|....*....|
gi 81170495 400 VEWGKNATRALIRGEATDET 419
Cdd:PRK00973 416 VELGKKITYALLGRSGYEEE 435
|
|
| Pgi |
COG0166 |
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate ... |
1-423 |
8.54e-130 |
|
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate isomerase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439936 Cd Length: 484 Bit Score: 383.34 E-value: 8.54e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 1 MHVDIGAALASAAdpgvERATLDDLDEQVAvAHERIEQGR--NKGE---FGYASLNLLEATDA---------ETIHDAVA 66
Cdd:COG0166 23 LLLDYSKNRITDE----TLELLLELAEEEE-AREALFAGEkiNPTEgraVLHGALRLPEAGEDvmpevreelARIKAFAE 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 67 PV---ADAESVITVGIGGSALGAKTITEALAEDPGSHV---VLDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLAN 140
Cdd:COG0166 98 KVrtgKRITDVVNIGIGGSDLGPRAVIEALKPYFRDGPrvhFVSNVDPDYLAELLAGLDPETTLFIVISKSGTTQETLTN 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 141 FLVVREAYEDRGV-DWTERIVVTTGESGPLRALADQHDLPTLPVPEGVPGRFSALSAVGLVPPAILGIDIEGLLAGGQQA 219
Cdd:COG0166 178 ARVAREWLEKAGGeDAAKHFVAVTDNAGALRAFGIDEGYNTFPFPDWVGGRYSVLSAVGLLPAAAIGIDFEELLAGAHAM 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 220 ADDLA-PSLYDSPAYAYGAMAYALEEA-GATVNAVMPYAERLESFGEWFAQLWAESLGKD--------GRGQTPARALGA 289
Cdd:COG0166 258 DEHFRtAPLEENPPVLLALLGIWYRNFkGAETEAVLPYDQRLERFPAWLQQLWMESNGKSvdrdgnpvGYGTGPVGEPGT 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 290 TDQHSQLQLYRAGHRDKVVTFVRPRERADvSIPD---PDHEDLSYLAGTDLGGLIDAEYEATVASLPAADRPALEVEIDR 366
Cdd:COG0166 338 TDQHSFGQLLHQGTRDIPVTFIAVAEPHH-DIPDlllANLQGLALLAGKTLDEVLALAAEATPHALFPGNRPSNTILLPK 416
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 81170495 367 LDAESVGELLYAMEAACVLVGELADVETFTQPAVEWGKNATRALIRGEATDETAVID 423
Cdd:COG0166 417 LTPYTLGALIALYEHAVFVQGVLWGINPFDQPGVELGKKLAFALLGKLGGEEAAAGD 473
|
|
| PRK03868 |
PRK03868 |
glucose-6-phosphate isomerase; Provisional |
23-405 |
1.12e-75 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 235168 Cd Length: 410 Bit Score: 241.76 E-value: 1.12e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 23 DDLDEQVAvahERIEQGRNKGEFGYASLNLLEATDAETIHDAVAPVADAESVITVGIGGSALGAKTITEALAEDPGSH-- 100
Cdd:PRK03868 13 IKTISSYF---ERINKEKESGEIGYYHLPDQSTSLIEESLKFVKDKESIKNIVVIGIGGSSLGVKAIYSFLKNEKNNKke 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 101 -VVLDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLANFLVVREAYE-DRGVDwtERIVVTTGESGPLRALADQHDL 178
Cdd:PRK03868 90 lHFLENTDPISINKTLSKINLENTLFIVISKSGTTIETISIFKYLLSHFKlDQELK--KNFLFITDPDSKLEQFAKENNI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 179 PTLPVPEGVPGRFSALSAVGLVPPAILGIDIEGLLAGGQQAADDLAPSLYDSpayaygamayALEEAG--AT------VN 250
Cdd:PRK03868 168 KCFNIPKNVGGRFSVLSAVGIVPLALCGYDIKALLEGAKACKDSFFEQKEDH----------ILKKAYfyAThknaynIN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 251 AVMPYAERLESFGEWFAQLWAESLGKDGR-----GQTPARALGATDQHSQLQLYRAGHRDKVVTFVRPRERAD-VSIPD- 323
Cdd:PRK03868 238 VLFSYSDALKGFNDWYVQLWGESLGKKQGyktrvGLTPIGLIGSRDQHSFLQLIMEGPRDKTVTFIKIKDFQNaPKIPNi 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 324 --PDHEDLSYLAGTDLGGLIDAEYEATVASLPAADRPALEVEIDRLDAESVGELLYAMEAACVLVGELADVETFTQPAVE 401
Cdd:PRK03868 318 slKGLESLDFVNGVSFNELINAQCDATMEALIAEDIPVDVITLEKLDEFSIGYLIYYYELLTSAVGKMLGINTYDQPGVE 397
|
....
gi 81170495 402 WGKN 405
Cdd:PRK03868 398 VGKR 401
|
|
| PGI_Meth |
NF040629 |
glucose-6-phosphate isomerase; |
41-401 |
4.86e-65 |
|
glucose-6-phosphate isomerase;
Pssm-ID: 468601 Cd Length: 396 Bit Score: 213.97 E-value: 4.86e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 41 NKGEFGYASLNLLEATDA------ETIH----DAVAPVADAESVITVGIGGSALGAKTITEALAEDPGSHVVLDNVDPEH 110
Cdd:NF040629 21 NKVDFTNAYSNLMEKLDNgvvgfrDVIYdenlDKYKSLNGYKNVVVVGMGGSILGTMAIYYAISPFNNNAYFIDNSDPEK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 111 VRRTLDGLSLADTAINVVSRSGTTAETLANFLVVREAYEDRGVDWTERIVVTTGesGPLRALADQHDLPTLPVPEGVPGR 190
Cdd:NF040629 101 TLSILKKVDLNESIIYIISKSGNTLETLVNYYLIKKRIEKLNSFKGKIVFITNG--GKLKREAEKNNYEIYSIPENVPGR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 191 FSALSAVGLVPPAILGIDIEGLLAGGQQAaDDLAPS--LYDSPAYAYGAMAYALEEAGATVNAVMPYAERLESFGEWFAQ 268
Cdd:NF040629 179 FSVFTAVGLAPLYSLGIDISKILEGAREM-DKLCQNedILKNPALLNGVIHYLYDKKGKDISVIMSYIESLKYFGEWYKQ 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 269 LWAESLGKDGRGQTPARALGATDQHSQLQLYRAGHRDKVVTFVRPRE-RADVSI--PDPDHEDLSylagTDLGGLIDAEY 345
Cdd:NF040629 258 LIGESLGKNGNGITPLLSIGAKDQHSLLQLYMDGKKDKIITFITTKKyRLDEEIvfEDINDEEIS----CMLSDIIKCEQ 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 81170495 346 EATVASLPAADRPALEVEIDRLDAESVGELLYAMEAACVLVGELADVETFTQPAVE 401
Cdd:NF040629 334 KATEIALTNNGVPNVRITLDEINEMTMGALLYMYEMQVGFMGELYNINAYNQPAVE 389
|
|
| pgi |
PRK14097 |
glucose-6-phosphate isomerase; Provisional |
11-401 |
3.25e-63 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 184504 Cd Length: 448 Bit Score: 210.47 E-value: 3.25e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 11 SAADPGVERATLDDLDEQVAVAHERIEQGRNKG-EF-GYasLNLLEATD----------AETIHDavapvaDAESVITVG 78
Cdd:PRK14097 9 SKALSFVGEHELEYLQPQVKAAHQTLHNGTGAGnDFlGW--LDLPENYDkeefarikkaAEKIKS------DSDVLVVIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 79 IGGSALGAKTITEALA------------EDPGSHVVLDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLANFLVVRE 146
Cdd:PRK14097 81 IGGSYLGARAAIEFLNhsfynllpkeqrKAPQIIFAGNSISSTYLADLLEYLKDKDFSINVISKSGTTTEPAIAFRIFKE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 147 AYEDR-GVDWT-ERIVVTTGES-GPLRALADQHDLPTLPVPEGVPGRFSALSAVGLVPPAILGIDIEGLLAGGQQAADDL 223
Cdd:PRK14097 161 LLEKKyGKEEAkKRIYATTDKAkGALKTLADAEGYETFVIPDDVGGRFSVLTAVGLLPIAVAGIDIDALMKGAADARKDY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 224 A-PSLYDSPAYAYGAMAYALEEAGATVNAVMPYAERLESFGEWFAQLWAESLGKDGRGQTPARALGATDQHSQLQLYRAG 302
Cdd:PRK14097 241 SsSDLSENPAYQYAAVRNILYRKGYTTEILVNYEPSLQYFSEWWKQLFGESEGKDQKGIFPASANFSTDLHSLGQYIQEG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 303 HRDKVVTFVRPRE-RADVSIPdPDHED---LSYLAGTDLGGLIDAEYEATVASLPAADRPALEVEIDRLDAESVGELLYA 378
Cdd:PRK14097 321 RRNLFETVIKVEKpRKDLTIP-EDEEDldgLNYLAGKTVDFVNKKAFEGTLLAHTDGGVPNIVVNIPELDEYTFGYLVYF 399
|
410 420
....*....|....*....|...
gi 81170495 379 MEAACVLVGELADVETFTQPAVE 401
Cdd:PRK14097 400 FEKACAISGYLLGVNPFDQPGVE 422
|
|
| SIS_PGI_2 |
cd05016 |
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ... |
249-410 |
1.96e-53 |
|
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.
Pssm-ID: 240147 Cd Length: 164 Bit Score: 175.87 E-value: 1.96e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 249 VNAVMPYAERLESFGEWFAQLWAESLGKDGR--------GQTPARALGATDQHSQLQLYRAGHRDKVVTFVRPReradvs 320
Cdd:cd05016 2 THALLPYSQRLERFPAWLQQLDMESNGKSVTrdgedyptGPIPWGAPGTNDQHSFFQLIHQGTKDKPVDFIAVK------ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 321 ipDPDHEDLSYLAGTDLGGLIDAEYEATVASLPA-ADRPALEVEIDRLDAESVGELLYAMEAACVLVGELADVETFTQPA 399
Cdd:cd05016 76 --KPQNDVLDYLAGKTLHDLLLANCLATREALMFpGGRPSNTIVLPELTPYTLGALLALYEHKTAVQGALLGINPFDQPG 153
|
170
....*....|.
gi 81170495 400 VEWGKNATRAL 410
Cdd:cd05016 154 VELGKKLAKKI 164
|
|
| SIS_PGI_1 |
cd05015 |
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ... |
72-205 |
1.80e-51 |
|
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.
Pssm-ID: 240146 Cd Length: 158 Bit Score: 170.40 E-value: 1.80e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 72 ESVITVGIGGSALGAKTITEALAEDPGSHV---VLDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLANFLVVREAY 148
Cdd:cd05015 21 TDVVVIGIGGSDLGPRAVYEALKPYFKGGLrlhFVSNVDPDDLAELLKKLDPETTLFIVISKSGTTLETLANARLAREWL 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 81170495 149 EDR-GVDWTERIVVTTGESGPLRALADQHDLPTLPVPEGVPGRFSALSAVGLVPPAIL 205
Cdd:cd05015 101 EEAgGDDLAKHFVAITDNGSGLLKKAGIEGLNTFEIPDWVGGRFSVLSSVGGLPLALA 158
|
|
| pgi |
PRK14096 |
glucose-6-phosphate isomerase; Provisional |
58-411 |
1.47e-45 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 237609 [Multi-domain] Cd Length: 528 Bit Score: 165.44 E-value: 1.47e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 58 AETIHDAVAPVADAES---VITVGIGGSALGAKTITEALAED-PGSHV-VLDNVDPEHVRRTLDGLS--LADTAINVVSR 130
Cdd:PRK14096 98 AAKVHSGTIKPPNGEKftdVLWIGIGGSALGPQFVAEALQPNsDGLNIhFIDNTDPDGIDRVLAELGdrLATTLVVVISK 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 131 SGTTAETLANFLVVREAYEDRGVDWTERIVVTTGESGPLRALADQHD-LPTLPVPEGVPGRFSALSAVGLVPPAILGIDI 209
Cdd:PRK14096 178 SGGTPETRNGMLEAKAAYEAAGLDFASHAVAITMKGSKLDQLAQSEGwLARFPMWDWVGGRTSETSAVGLLPAALQGIDI 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 210 EGLLAGGQQaADDLA--PSLYDSPayaygamAYALEEA--------GATVNAVMPYAERLESFGEWFAQLWAESLGK--D 277
Cdd:PRK14096 258 RAFLAGAKQ-MDEATrvPDLKNNP-------AALLALAwyyagdgkGKKDMVVLPYKDRLLLFSRYLQQLVMESLGKelD 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 278 GRGQTPARAL------GATDQHSQLQLYRAGHRDKVVTFVRPREradvsipDPDHEDLSYLAGTDLGGLIDAEYEATVAS 351
Cdd:PRK14096 330 LDGNVVHQGIavygnkGSTDQHAYVQQLRDGVDNFFVTFIEVLE-------DRQGSSIEVEPGVTSGDYLSGFLQGTRQA 402
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 352 LPAADRPALEVEIDRLDAESVGELLYAMEAACVLVGELADVETFTQPAVEWGKNATRALI 411
Cdd:PRK14096 403 LYENGRQSITITIPEVNPRTLGALIALFERAVGLYASLVNINAYHQPGVEAGKKAAAAIL 462
|
|
| PLN02649 |
PLN02649 |
glucose-6-phosphate isomerase |
73-404 |
1.22e-28 |
|
glucose-6-phosphate isomerase
Pssm-ID: 215351 [Multi-domain] Cd Length: 560 Bit Score: 118.22 E-value: 1.22e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 73 SVITVGIGGSALGAKTITEALAEDPGSHVV--------LDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLANFLVV 144
Cdd:PLN02649 149 NVVSIGIGGSFLGPLFVHEALATDPEALKSakgrklrfLANVDPVDIARQIAQLDPETTLVVVVSKTFTTAETMLNARTV 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 145 REAYEDR-GVDWTERIVVttgesgplrALADQHDL-------PTLPVP--EGVPGRFSALSAVGLVPPAI-LGID-IEGL 212
Cdd:PLN02649 229 RKWLRDAlGGLAVAKHMV---------AVSTNLLLvnkfgidPWNAFPfwDWVGGRYSVCSAVGLLPLSLqYGFDvVEEF 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 213 LAGgqqaADDLAPSLYDSPAYAYGAMAYAL------EEAGATVNAVMPYAERLESFGEWFAQLWAESLGK----DGR--- 279
Cdd:PLN02649 300 LEG----AASMDEHFRTAPLKENIPVLLGLlsvwnsSFLGYPARAILPYSQALLKFAPHIQQLDMESNGKgvdlDGNplp 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 280 ---GQTPARALGATDQHSQLQLYRAGhRDKVVTFVRPReRADVSIPDPDHEDLS--------YLAGTD----LGGLIDAE 344
Cdd:PLN02649 376 vntGEIDFGEPGTNGQHSFYQLIHQG-RNIPCDFIGVV-RSQQPVHLWLGEGVSnhdelmsnFFAQPDalayGKTPEQLR 453
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81170495 345 YEATVASLP-----AADRPALEVEIDRLDAESVGELLYAMEAACVLVGELADVETFTQPAVEWGK 404
Cdd:PLN02649 454 AEGVPEELIphkvfAGNRPSLSILLPELTAYTVGQLLALYEHRVAVQGFIWNINSFDQWGVELGK 518
|
|
| PGI |
pfam00342 |
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of ... |
74-404 |
2.25e-23 |
|
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.
Pssm-ID: 395271 Cd Length: 487 Bit Score: 102.17 E-value: 2.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 74 VITVGIGGSALGAKTITEALAEDPGSHV---VLDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLANFLVVREAYED 150
Cdd:pfam00342 99 VVNIGIGGSDLGPVMVTEALKPYSGRDLdvhFVSNVDGTHIAEVLKKLNPETTLFIVASKTFTTAETMTNAESAKEWLLK 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 151 RGVD---WTERIVVTTGESGPLRALA-DQHDLptLPVPEGVPGRFSALSAVGLvpPAILGIDIEG---LLAGGqqAADD- 222
Cdd:pfam00342 179 ALKDdsaVAKHFIALSTNAEKVEEFGiDTKNM--FEFWDWVGGRYSLWSAIGL--PIALSIGFENfqqLLEGA--HAMDk 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 223 ---LAPSLYDSPAYAYGAMAYALEEAGATVNAVMPYAERLESFGEWFAQLWAESLGK--DGRGQTPARALG-------AT 290
Cdd:pfam00342 253 hflSAPPEKNIPVLLALLGVWYNNFFGAQTHAILPYDQYLHRFPAYLQQLDMESNGKyvTRDGVLVDHQTGpiifgepGT 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 291 D-QHSQLQLYRAGHRDKVVTFVRPRERADVSIPDPDHEDLS-YLAGTDL------GGLIDAEYEATV--ASLPA----AD 356
Cdd:pfam00342 333 NgQHAFYQLIHQGTRLIPCDFIGAVQSQNPENGDHHKILLSnFFAQTEAlmvgksPEEVRKELAAADveHLIPHktftGN 412
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 81170495 357 RPALEVEIDRLDAESVGELLYAMEAACVLVGELADVETFTQPAVEWGK 404
Cdd:pfam00342 413 RPSNSILVQKLTPATLGALIAMYEHKIFVQGAIWGINSFDQWGVELGK 460
|
|
| pgi |
PRK14095 |
glucose-6-phosphate isomerase; Provisional |
74-276 |
7.32e-23 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 237608 Cd Length: 533 Bit Score: 100.86 E-value: 7.32e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 74 VITVGIGGSALGAKTITEALAE--DPGSHV-VLDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLANFLVVREAYED 150
Cdd:PRK14095 154 VVQIGIGGSDLGPKALYLALKNyaKKDKRVhFISNVDPDDAAEVLSEIDLAKTLFIVVSKSGTTLETAANEEFVRDALKK 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 151 RGVDWTERIVVTTGESGPLrALADQHdLPTLPVPEGVPGRFSALSAVGLVPPAI-LGIDIEGLLAGGQQAADDLA--PSL 227
Cdd:PRK14095 234 AGLDYKKHFIAVTSEGSPM-DDESGY-LEVFHMWDSIGGRFSSTSMVGGVVLGFaFGFEVFKEFLKGAAAMDKAAlnPNI 311
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 81170495 228 YDSPayaygamayALEEA----------GATVNAVMPYAERLESFGEWFAQLWAESLGK 276
Cdd:PRK14095 312 RENL---------PLLAAligiwnrnflGYPTTAVIPYSQALERFPAHLQQLDMESNGK 361
|
|
| PRK09533 |
PRK09533 |
bifunctional transaldolase/phosoglucose isomerase; Validated |
74-424 |
1.91e-22 |
|
bifunctional transaldolase/phosoglucose isomerase; Validated
Pssm-ID: 236551 [Multi-domain] Cd Length: 948 Bit Score: 100.43 E-value: 1.91e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 74 VITVGIGGSALGAKTITEALAEDPG--SHVVLDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLANFLVVREAYEDR 151
Cdd:PRK09533 458 AVVLGMGGSSLGPEVLAETFGQRDGfpKLHVLDSTDPAQVRALEAAVDLARTLFIVSSKSGGTLEPNIFKDYFFARVKEV 537
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 152 -GVDWTERIVVTTGESGPLRALADQ-------HDLPTlpvpegVPGRFSALSAVGLVPPAILGIDIEGLLAGGQQAADDL 223
Cdd:PRK09533 538 lGAKAGRHFVAVTDPGSSLEKVAKEdgfrkifHGDPD------IGGRYSVLSPFGLVPAAAAGIDVRALLDSALAMVRSC 611
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 224 APSLydspayaygamaYALEEAGATVNAVMPYA-------------ERLESFGEWFAQLWAESLGKDGRGQTP--ARALG 288
Cdd:PRK09533 612 GPSV------------PPADNPGVQLGLALGVAatqgrdkvtivasPAIADFGAWAEQLIAESTGKEGKGLIPidGEPLG 679
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 289 ATDQHSQlqlyraghrDKVVTFVRpreradvsipdpdhedlsyLAGTDlggliDAEYEATVASLPAADRPALEVEIDrlD 368
Cdd:PRK09533 680 DPAVYGN---------DRVFVYLR-------------------LAGEA-----DAAQDAALAALEAAGHPVVRIVLD--S 724
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81170495 369 AESVGELLYAMEAACVLVGELADVETFTQPAVEWGKNATRALI-----RGEATDETAVIDE 424
Cdd:PRK09533 725 AEQLGQEFFRWEMATAVAGAVLGINPFDQPDVEASKIKTRELTaayekTGALPAETPAASD 785
|
|
| pgi |
PRK00179 |
glucose-6-phosphate isomerase; Reviewed |
74-423 |
2.63e-17 |
|
glucose-6-phosphate isomerase; Reviewed
Pssm-ID: 234679 Cd Length: 548 Bit Score: 84.07 E-value: 2.63e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 74 VITVGIGGSALGAKTITEALAE--DPGSHV-VLDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLANFLVVREAYED 150
Cdd:PRK00179 148 VVNIGIGGSDLGPVMVTEALRPyaDPGLRVhFVSNVDGAHLAETLKKLDPETTLFIVASKTFTTQETLTNAHSARDWFLA 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 151 RGVDWTER----IVVTTgesgPLRALAD-----QHdlpTLPVPEGVPGRFSALSAVGLvPPAI-LGID-IEGLLAGGqQA 219
Cdd:PRK00179 228 AGGDEAAVakhfVAVST----NAEAVAEfgidpDN---MFGFWDWVGGRYSLWSAIGL-SIALaIGPDnFEELLAGA-HA 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 220 ADD---LAPslydspayaygamayaLEEA----------------GATVNAVMPYAERLESFGEWFAQLWAESLGK--DG 278
Cdd:PRK00179 299 MDEhfrTAP----------------LEKNlpvllaligvwyrnffGAQSHAVLPYDQYLHRFPAYLQQLEMESNGKsvDR 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 279 RGQTPARALGA-------TD-QHSQLQLYRAGHRDKVVTFVRPRERADvsiPDPDHEDLSY---LAGTD---LG-GLIDA 343
Cdd:PRK00179 363 DGTPVDYQTGPiiwgepgTNgQHAFFQLLHQGTKLVPADFIAPAQPHN---PLGDHHDLLLancFAQTEalmFGkTAEEV 439
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 344 EYEATVASLPAA-------------DRPALEVEIDRLDAESVGELLyAMEAACVLV-GELADVETFTQPAVEWGKN-ATR 408
Cdd:PRK00179 440 RAELRAKGLDEAeaeelaphkvfpgNRPSTTILLDRLTPFTLGALI-ALYEHKVFVqGVIWGINSFDQWGVELGKQlAKR 518
|
410
....*....|....*
gi 81170495 409 ALIRGEATDETAVID 423
Cdd:PRK00179 519 ILPELEGDSEASAHD 533
|
|
| PTZ00430 |
PTZ00430 |
glucose-6-phosphate isomerase; Provisional |
73-404 |
3.07e-17 |
|
glucose-6-phosphate isomerase; Provisional
Pssm-ID: 185612 Cd Length: 552 Bit Score: 83.91 E-value: 3.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 73 SVITVGIGGSALGAKTITEALAEDPGSHVV--------LDNVDPEHVRRTLDGLSLADTAINVVSRSGTTAETLANFLVV 144
Cdd:PTZ00430 144 NVICIGIGGSYLGTEFVYEALRTYGEAREAskgrklrfLANVDPIDVRRATEGLDPEETLVVIISKTFTTAETMLNAKTV 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 145 R----EAYEDRGVDWTERIVVTTGesgplRALADQHDLPTLPVPE---GVPGRFSALSAVGLVPPAI-LGIDIEGLLAGG 216
Cdd:PTZ00430 224 RqwllDNIKSKEALSKHLCAVSTN-----LKLTSEFGIPDENVFGfwdWVGGRFSVTSAVGILPLSIqFGYDIVQQFLNG 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 217 QQAAD------DLA---P------SLYDSPAYaygamayaleeaGATVNAVMPYAERLESFGEWFAQLWAESLGK--DGR 279
Cdd:PTZ00430 299 CHDMDehfrtaPLEenlPvllgltSFYNSTFL------------GYNCVAILPYCQALLKFPAHVQQLLMESNGKsvTLD 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 280 GQT------------ParalGATDQHSQLQLYragHRDKVVtfvrPRE-------RADVSIPDPD---HEDL--SYLAGT 335
Cdd:PTZ00430 367 GNTldyntgeiyfgeP----GTNGQHSFYQLL---HQGRVV----PSEfigfaksQNPIKLLGEPvsnHDELmsNFFAQP 435
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 336 DlgGL-IDAEYEATVA-SLPA---------ADRPALEVEIDRLDAESVGELLYAMEAACVLVGELADVETFTQPAVEWGK 404
Cdd:PTZ00430 436 D--ALaFGKTYEELEKeGVPEeliphkvfpGNRPSLLLLFPELNPYTIGQLLALYEHRTVVEGFLWNINSFDQWGVELGK 513
|
|
| SIS_TAL_PGI |
cd05798 |
SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the ... |
257-410 |
1.10e-08 |
|
SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a C-terminal PGI domain. TAL catalyzes the reversible conversion of sedoheptulose-7-phosphate (S7P) and glyceraldehyde-3-phosphate (G3P), to fructose-6-phosphate (F6P) and erythrose-4-phosphate (E4P). PGI catalyzes the reversible isomerization of F6P to glucose-6-phosphate (G6P). It has been suggested for Gluconobacter oxydans TAL_PGI that this enzyme generates E4P and G6P directly from S7P and G3P. G. oxydans TAL_PGI contributes to increased xylitol production from D-arabitol. As xylitol is an alternative natural sweetner to sucrose, the microbial conversion of D-arabitol to xylitol is of interest to food and pharmaceutical industries.
Pssm-ID: 240224 [Multi-domain] Cd Length: 129 Bit Score: 53.23 E-value: 1.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 257 ERLESFGEWFAQLWAESLGKDGRGQTP--ARALGATDQHSqlqlyraghRDKVvtFVRpreradvsipdpdhedlsylag 334
Cdd:cd05798 9 PGIASLGAWLEQLIAESTGKEGKGIIPvdGEPLGDPAVYG---------DDRV--FVY---------------------- 55
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81170495 335 TDLGGLIDAEYEATVASLPAADRPALEVEIDrlDAESVGELLYAMEAACVLVGELADVETFTQPAVEWGKNATRAL 410
Cdd:cd05798 56 LRLAGEADADQEEALLALEAAGHPVIRIDLD--DAYDLGQEFFRWEMATAVAGAVLGINPFDQPDVEASKIETRRL 129
|
|
| SIS_PGI_PMI_1 |
cd05017 |
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the ... |
74-192 |
5.72e-08 |
|
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain.
Pssm-ID: 240148 [Multi-domain] Cd Length: 119 Bit Score: 51.11 E-value: 5.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 74 VITVGIGGSALGAKtITEALAEDPGS---HVVLDNVDPEHVRRtldglslaDTAINVVSRSGTTAETLAnflVVREAYEd 150
Cdd:cd05017 2 IVILGMGGSGIGGD-LLESLLLDEAKipvYVVKDYTLPAFVDR--------KTLVIAVSYSGNTEETLS---AVEQAKE- 68
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 81170495 151 RGVDwteRIVVTTGesGPLRALADQHDLPTLPVPEGVPGRFS 192
Cdd:cd05017 69 RGAK---IVAITSG--GKLLEMAREHGVPVIIIPKGLQPRAA 105
|
|
| PRK08674 |
PRK08674 |
bifunctional phosphoglucose/phosphomannose isomerase; Validated |
74-225 |
9.60e-08 |
|
bifunctional phosphoglucose/phosphomannose isomerase; Validated
Pssm-ID: 181536 [Multi-domain] Cd Length: 337 Bit Score: 53.45 E-value: 9.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 74 VITvGIGGSALGAKtITEALAEDPGSHVVLDNVD---PEHVRRtldglslaDTAINVVSRSGTTAETLAnflVVREAYEd 150
Cdd:PRK08674 38 VIS-GMGGSGIGGD-LLRILLFDELKVPVFVNRDytlPAFVDE--------KTLVIAVSYSGNTEETLS---AVEQALK- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 151 RGVdwtERIVVTTGesGPLRALADQHDLPTLPVPEGVPGR------FSALSAV----GLVPPAIlgIDIEGLLAGGQQAA 220
Cdd:PRK08674 104 RGA---KIIAITSG--GKLKEMAKEHGLPVIIVPGGYQPRaalgylFTPLLKIleklGLIPDKS--AEVLETKIVLSELA 176
|
....*
gi 81170495 221 DDLAP 225
Cdd:PRK08674 177 EGLKE 181
|
|
| AgaS |
COG2222 |
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ... |
55-186 |
6.55e-03 |
|
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441824 [Multi-domain] Cd Length: 336 Bit Score: 38.34 E-value: 6.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81170495 55 ATDAETIHDAVAPVADA--ESVITVGIGGSALGAKTITEALAEDPGSHVVLdnVDPEHVRRTLDGLSLADTAINVVSRSG 132
Cdd:COG2222 16 AALAAAIAALLARLRAKppRRVVLVGAGSSDHAAQAAAYLLERLLGIPVAA--LAPSELVVYPAYLKLEGTLVVAISRSG 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 81170495 133 TTAETLAnflVVREAyEDRGVDwteRIVVTTGESGPLRALADQhdlpTLPVPEG 186
Cdd:COG2222 94 NSPEVVA---ALELA-KARGAR---TLAITNNPDSPLAEAADR----VLPLPAG 136
|
|
| |
