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Conserved domains on  [gi|284018151|sp|Q55E65|]
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RecName: Full=Putative uncharacterized protein DDB_G0270496

Protein Classification

AATF family protein( domain architecture ID 10595130)

apoptosis-antagonizing transcription factor (AATF) family protein, such as AATF, also called Che-1, which has been shown to play a crucial role in cell cycle control, apoptosis, and chromatin remodeling due to its interaction with various important components of cell survival machinery including Retinoblastoma(Rb), DAP like kinases(DLK) and histone deacetylases (HDACs)

Gene Ontology:  GO:0043522|GO:0019901|GO:0042254|GO:0006974
PubMed:  33145763

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AATF-Che1 pfam13339
Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the ...
 221-348 2.02e-26

Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the apoptosis antagonizing transcription factor-Che1.


:

Pssm-ID: 463850  Cd Length: 136  Bit Score: 104.39  E-value: 2.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284018151  221 EMEKAQNTKNQTALYNEFLTTRILLQKTINCANKLPKPKIYKEFLElNDESLQKKFKETKTASCLLISELYNLQSEL--- 297
Cdd:pfam13339   1 DAEKGKAVKNQRKLWDSLLELRIKLQKALTAANQLPQPEARSEFLK-SDEEFSEALEEAEKALKKLLDTLLELREELqqn 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 284018151  298 ---IDLNDEIPKQQQSKKR---IRPDQSLSEIWNTIEEQNQRLDQFHNQTITKWNNR 348
Cdd:pfam13339  80 panASSSEDEEKSGKKRKRkrkDDSDTSLDDLWEELEKLEARLLPYRNAVLDKWSRK 136
TRAUB pfam08164
Apoptosis-antagonizing transcription factor, C-terminal; This C terminal domain is found in ...
 434-512 1.31e-22

Apoptosis-antagonizing transcription factor, C-terminal; This C terminal domain is found in traube proteins. This is the domain of the AATF proteins that interacts with BLOS2 or Ceap, that functions as an adaptor in processes such as protein and vesicle processing and transport, and perhaps transcription.


:

Pssm-ID: 462388  Cd Length: 81  Bit Score: 91.48  E-value: 1.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284018151  434 YQTLLKDLEANNSEENEVGSQYWIEMRNLKKKKK-KKVNQKASKGRILRYEVFPKLENFMTPQ-SLPIPDWNIDQLYQNL 511
Cdd:pfam08164   1 YQQLLKELIESKTADSSAGSGDPLALQALRKKKKkKKVDTKASKGRKLRYTVHEKLQNFMAPIpRGTWPDEQIDELFASL 80


                  .
gi 284018151  512 F 512
Cdd:pfam08164  81 F 81
 
Name Accession Description Interval E-value
AATF-Che1 pfam13339
Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the ...
 221-348 2.02e-26

Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the apoptosis antagonizing transcription factor-Che1.


Pssm-ID: 463850  Cd Length: 136  Bit Score: 104.39  E-value: 2.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284018151  221 EMEKAQNTKNQTALYNEFLTTRILLQKTINCANKLPKPKIYKEFLElNDESLQKKFKETKTASCLLISELYNLQSEL--- 297
Cdd:pfam13339   1 DAEKGKAVKNQRKLWDSLLELRIKLQKALTAANQLPQPEARSEFLK-SDEEFSEALEEAEKALKKLLDTLLELREELqqn 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 284018151  298 ---IDLNDEIPKQQQSKKR---IRPDQSLSEIWNTIEEQNQRLDQFHNQTITKWNNR 348
Cdd:pfam13339  80 panASSSEDEEKSGKKRKRkrkDDSDTSLDDLWEELEKLEARLLPYRNAVLDKWSRK 136
TRAUB pfam08164
Apoptosis-antagonizing transcription factor, C-terminal; This C terminal domain is found in ...
 434-512 1.31e-22

Apoptosis-antagonizing transcription factor, C-terminal; This C terminal domain is found in traube proteins. This is the domain of the AATF proteins that interacts with BLOS2 or Ceap, that functions as an adaptor in processes such as protein and vesicle processing and transport, and perhaps transcription.


Pssm-ID: 462388  Cd Length: 81  Bit Score: 91.48  E-value: 1.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284018151  434 YQTLLKDLEANNSEENEVGSQYWIEMRNLKKKKK-KKVNQKASKGRILRYEVFPKLENFMTPQ-SLPIPDWNIDQLYQNL 511
Cdd:pfam08164   1 YQQLLKELIESKTADSSAGSGDPLALQALRKKKKkKKVDTKASKGRKLRYTVHEKLQNFMAPIpRGTWPDEQIDELFASL 80


                  .
gi 284018151  512 F 512
Cdd:pfam08164  81 F 81
 
Name Accession Description Interval E-value
AATF-Che1 pfam13339
Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the ...
 221-348 2.02e-26

Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the apoptosis antagonizing transcription factor-Che1.


Pssm-ID: 463850  Cd Length: 136  Bit Score: 104.39  E-value: 2.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284018151  221 EMEKAQNTKNQTALYNEFLTTRILLQKTINCANKLPKPKIYKEFLElNDESLQKKFKETKTASCLLISELYNLQSEL--- 297
Cdd:pfam13339   1 DAEKGKAVKNQRKLWDSLLELRIKLQKALTAANQLPQPEARSEFLK-SDEEFSEALEEAEKALKKLLDTLLELREELqqn 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 284018151  298 ---IDLNDEIPKQQQSKKR---IRPDQSLSEIWNTIEEQNQRLDQFHNQTITKWNNR 348
Cdd:pfam13339  80 panASSSEDEEKSGKKRKRkrkDDSDTSLDDLWEELEKLEARLLPYRNAVLDKWSRK 136
TRAUB pfam08164
Apoptosis-antagonizing transcription factor, C-terminal; This C terminal domain is found in ...
 434-512 1.31e-22

Apoptosis-antagonizing transcription factor, C-terminal; This C terminal domain is found in traube proteins. This is the domain of the AATF proteins that interacts with BLOS2 or Ceap, that functions as an adaptor in processes such as protein and vesicle processing and transport, and perhaps transcription.


Pssm-ID: 462388  Cd Length: 81  Bit Score: 91.48  E-value: 1.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284018151  434 YQTLLKDLEANNSEENEVGSQYWIEMRNLKKKKK-KKVNQKASKGRILRYEVFPKLENFMTPQ-SLPIPDWNIDQLYQNL 511
Cdd:pfam08164   1 YQQLLKELIESKTADSSAGSGDPLALQALRKKKKkKKVDTKASKGRKLRYTVHEKLQNFMAPIpRGTWPDEQIDELFASL 80


                  .
gi 284018151  512 F 512
Cdd:pfam08164  81 F 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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