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Conserved domains on  [gi|1706799|sp|P02671|]
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RecName: Full=Fibrinogen alpha chain; Contains: RecName: Full=Fibrinopeptide A; Contains: RecName: Full=Fibrinogen alpha chain; Flags: Precursor

Protein Classification

Fib_alpha and FReD domain-containing protein( domain architecture ID 10554887)

protein containing domains Fib_alpha, Fibrinogen_aC, and FReD

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 630-863 1.11e-109

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


:

Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 335.36  E-value: 1.11e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799  630 RDCDDVLQTHpsGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNdegeGEFWL 709
Cdd:cd00087   4 RDCSEVLQRG--GRTSGVYTIQPPGSNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLD----GEFWL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799  710 GNDYLHLLTQRG-SVLRVELEDWAGNEAYAEY-HFRVGSEAEGYALQVSSYEGTAGDALiegsveegaeyTSHNNMQFST 787
Cdd:cd00087  78 GLEKIHLLTSQGpYELRIDLEDWEGNTAYAEYdSFKVGSESEGYRLTLGGYSGTAGDAL-----------SYHNGMKFST 146

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706799  788 FDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGsydprnnSPYEIENGVVWVSFRGADYSLRAVRMKIRPL 863
Cdd:cd00087 147 FDRDNDGASGNCAESYSGGWWYNSCHASNLNGRYYSGG-------HRNEYDNGINWATWKGSTYSLKFTEMKIRPK 215
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 49-191 5.74e-62

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


:

Pssm-ID: 462570  Cd Length: 143  Bit Score: 205.47  E-value: 5.74e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799     49 DSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYN 128
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706799    129 RVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALARE 191
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQESNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
Fibrinogen_aC pfam12160
Fibrinogen alpha C domain; This domain family is found in eukaryotes, and is approximately 70 ...
 445-509 4.48e-24

Fibrinogen alpha C domain; This domain family is found in eukaryotes, and is approximately 70 amino acids in length, and the family is found in association with pfam08702. This domain is the C terminal domain of fibrinogen in mammals. The domain lies in the C terminal half of the alpha C region in these proteins. The function of the domain is that of intramolecular and intermolecular interactions to form fibrin.


:

Pssm-ID: 432370  Cd Length: 68  Bit Score: 96.06  E-value: 4.48e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1706799    445 GKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLG---TLSGIGTLDGF 509
Cdd:pfam12160   1 GKEKVTSGGTTTTRRSCSKTITKTVIGPDGRKEVTKEVVTSEDGSDCGDATDLDtfhTFSGRGSLDEF 68
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 630-863 1.11e-109

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 335.36  E-value: 1.11e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799  630 RDCDDVLQTHpsGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNdegeGEFWL 709
Cdd:cd00087   4 RDCSEVLQRG--GRTSGVYTIQPPGSNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLD----GEFWL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799  710 GNDYLHLLTQRG-SVLRVELEDWAGNEAYAEY-HFRVGSEAEGYALQVSSYEGTAGDALiegsveegaeyTSHNNMQFST 787
Cdd:cd00087  78 GLEKIHLLTSQGpYELRIDLEDWEGNTAYAEYdSFKVGSESEGYRLTLGGYSGTAGDAL-----------SYHNGMKFST 146

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706799  788 FDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGsydprnnSPYEIENGVVWVSFRGADYSLRAVRMKIRPL 863
Cdd:cd00087 147 FDRDNDGASGNCAESYSGGWWYNSCHASNLNGRYYSGG-------HRNEYDNGINWATWKGSTYSLKFTEMKIRPK 215
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 630-863 4.46e-102

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 315.37  E-value: 4.46e-102
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799     630 RDCDDVLQThpSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNdegeGEFWL 709
Cdd:smart00186   3 RDCSDVLQN--GGKTSGLYTIYPDGSSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLA----GEFWL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799     710 GNDYLHLLT-QRGSVLRVELEDWAGNEAYAEY-HFRVGSEAEGYALQVSSYEGTAGDAliegsveegaEYTSHNNMQFST 787
Cdd:smart00186  77 GNENIHLLTsQGKYELRIDLEDWEGNTAYALYdSFKVADEADGYRLHIGGYSGTAGDA----------SLTYHNGMQFST 146

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706799     788 FDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPggsydprnnsPYEIENGVVWVSFRGADYSLRAVRMKIRPL 863
Cdd:smart00186 147 YDRDNDKYSGNCAEEYGGGWWYNNCHAANLNGRYYP----------NNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
630-863 5.31e-77

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 249.36  E-value: 5.31e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799    630 RDCDDVLQThpSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNdegEGEFWL 709
Cdd:pfam00147   3 RDCSDVYNK--GAKTSGLYTIRPDGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLS---PGEFWL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799    710 GNDYLHLLTQRGS-VLRVELEDWAGNEAYAEY-HFRVGSEAEGYALQVSSYEGTAGDALIEgsveEGAEYTSHNNMQFST 787
Cdd:pfam00147  78 GNDKIHLLTKQGPyVLRIDLEDWNGETVFALYdSFKVTNENDKYRLHVENYIGDAGDALDT----AGRSMTYHNGMQFST 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706799    788 FDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRnnspyeieNGVVWVSFRGADYSLRAVRMKIRPL 863
Cdd:pfam00147 154 WDRDNDSPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSKQ--------NGIIWATWKGRWYSMKKAEMKIRPL 221
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 49-191 5.74e-62

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 462570  Cd Length: 143  Bit Score: 205.47  E-value: 5.74e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799     49 DSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYN 128
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706799    129 RVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALARE 191
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQESNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
Fibrinogen_aC pfam12160
Fibrinogen alpha C domain; This domain family is found in eukaryotes, and is approximately 70 ...
 445-509 4.48e-24

Fibrinogen alpha C domain; This domain family is found in eukaryotes, and is approximately 70 amino acids in length, and the family is found in association with pfam08702. This domain is the C terminal domain of fibrinogen in mammals. The domain lies in the C terminal half of the alpha C region in these proteins. The function of the domain is that of intramolecular and intermolecular interactions to form fibrin.


Pssm-ID: 432370  Cd Length: 68  Bit Score: 96.06  E-value: 4.48e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1706799    445 GKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLG---TLSGIGTLDGF 509
Cdd:pfam12160   1 GKEKVTSGGTTTTRRSCSKTITKTVIGPDGRKEVTKEVVTSEDGSDCGDATDLDtfhTFSGRGSLDEF 68
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 632-675 8.83e-07

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 46.40  E-value: 8.83e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 1706799   632 CDDVLQTHPSgTQSGIFNIKLPGSSKI--FSVYCDQETSLGGWLLI 675
Cdd:NF040941   2 CWEILQAGPS-APSGVYWIDPDGMGGLapFQVYCDMTTDGGGWTLV 46
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 630-863 1.11e-109

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 335.36  E-value: 1.11e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799  630 RDCDDVLQTHpsGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNdegeGEFWL 709
Cdd:cd00087   4 RDCSEVLQRG--GRTSGVYTIQPPGSNEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLD----GEFWL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799  710 GNDYLHLLTQRG-SVLRVELEDWAGNEAYAEY-HFRVGSEAEGYALQVSSYEGTAGDALiegsveegaeyTSHNNMQFST 787
Cdd:cd00087  78 GLEKIHLLTSQGpYELRIDLEDWEGNTAYAEYdSFKVGSESEGYRLTLGGYSGTAGDAL-----------SYHNGMKFST 146

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706799  788 FDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGsydprnnSPYEIENGVVWVSFRGADYSLRAVRMKIRPL 863
Cdd:cd00087 147 FDRDNDGASGNCAESYSGGWWYNSCHASNLNGRYYSGG-------HRNEYDNGINWATWKGSTYSLKFTEMKIRPK 215
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 630-863 4.46e-102

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 315.37  E-value: 4.46e-102
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799     630 RDCDDVLQThpSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNdegeGEFWL 709
Cdd:smart00186   3 RDCSDVLQN--GGKTSGLYTIYPDGSSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLA----GEFWL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799     710 GNDYLHLLT-QRGSVLRVELEDWAGNEAYAEY-HFRVGSEAEGYALQVSSYEGTAGDAliegsveegaEYTSHNNMQFST 787
Cdd:smart00186  77 GNENIHLLTsQGKYELRIDLEDWEGNTAYALYdSFKVADEADGYRLHIGGYSGTAGDA----------SLTYHNGMQFST 146

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706799     788 FDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPggsydprnnsPYEIENGVVWVSFRGADYSLRAVRMKIRPL 863
Cdd:smart00186 147 YDRDNDKYSGNCAEEYGGGWWYNNCHAANLNGRYYP----------NNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
630-863 5.31e-77

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 249.36  E-value: 5.31e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799    630 RDCDDVLQThpSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNdegEGEFWL 709
Cdd:pfam00147   3 RDCSDVYNK--GAKTSGLYTIRPDGATKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLS---PGEFWL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799    710 GNDYLHLLTQRGS-VLRVELEDWAGNEAYAEY-HFRVGSEAEGYALQVSSYEGTAGDALIEgsveEGAEYTSHNNMQFST 787
Cdd:pfam00147  78 GNDKIHLLTKQGPyVLRIDLEDWNGETVFALYdSFKVTNENDKYRLHVENYIGDAGDALDT----AGRSMTYHNGMQFST 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706799    788 FDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRnnspyeieNGVVWVSFRGADYSLRAVRMKIRPL 863
Cdd:pfam00147 154 WDRDNDSPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSKQ--------NGIIWATWKGRWYSMKKAEMKIRPL 221
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 49-191 5.74e-62

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 462570  Cd Length: 143  Bit Score: 205.47  E-value: 5.74e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706799     49 DSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYN 128
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706799    129 RVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALARE 191
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQESNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEIQ 143
Fibrinogen_aC pfam12160
Fibrinogen alpha C domain; This domain family is found in eukaryotes, and is approximately 70 ...
 445-509 4.48e-24

Fibrinogen alpha C domain; This domain family is found in eukaryotes, and is approximately 70 amino acids in length, and the family is found in association with pfam08702. This domain is the C terminal domain of fibrinogen in mammals. The domain lies in the C terminal half of the alpha C region in these proteins. The function of the domain is that of intramolecular and intermolecular interactions to form fibrin.


Pssm-ID: 432370  Cd Length: 68  Bit Score: 96.06  E-value: 4.48e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1706799    445 GKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLG---TLSGIGTLDGF 509
Cdd:pfam12160   1 GKEKVTSGGTTTTRRSCSKTITKTVIGPDGRKEVTKEVVTSEDGSDCGDATDLDtfhTFSGRGSLDEF 68
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 632-675 8.83e-07

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 46.40  E-value: 8.83e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 1706799   632 CDDVLQTHPSgTQSGIFNIKLPGSSKI--FSVYCDQETSLGGWLLI 675
Cdd:NF040941   2 CWEILQAGPS-APSGVYWIDPDGMGGLapFQVYCDMTTDGGGWTLV 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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