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Conserved domains on  [gi|47086813|ref|NP_997775|]
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histone-binding protein RBBP7 [Danio rerio]

Protein Classification

WD repeat RBAP46/RBAP48/MSI1 family protein( domain architecture ID 12115235)

WD repeat RBAP46/RBAP48/MSI1 family protein binds histones, similar to Saccharomyces cerevisiae histone acetyltransferase type B subunit 2

Gene Ontology:  GO:0005515|GO:0042393
PubMed:  10322433
SCOP:  4005630

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
172-405 5.48e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 5.48e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 172 RLRGHQKEGYGLSWNPNlsGNLL-SASDDHTICLWDIsgapKEGKIVdakTIFTGHTAVVEDVSWHLlHESLFGSVADDQ 250
Cdd:COG2319 157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDL----ATGKLL---RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 251 KLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 330
Cdd:COG2319 227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47086813 331 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 405
Cdd:COG2319 301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 18-87 2.72e-33

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


:

Pssm-ID: 463513  Cd Length: 69  Bit Score: 119.61  E-value: 2.72e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47086813    18 EEYKIWKKNTPFLYDLVMTHALEWPSLTVQWLPDvnRPEGKDYVVHRLVLGTHTSD-EQNHLVIASAQIPN 87
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
172-405 5.48e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 5.48e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 172 RLRGHQKEGYGLSWNPNlsGNLL-SASDDHTICLWDIsgapKEGKIVdakTIFTGHTAVVEDVSWHLlHESLFGSVADDQ 250
Cdd:COG2319 157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDL----ATGKLL---RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 251 KLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 330
Cdd:COG2319 227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47086813 331 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 405
Cdd:COG2319 301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-403 1.11e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.15  E-value: 1.11e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 172 RLRGHQKEGYGLSWNPNLSgNLLSASDDHTICLWDIsgapKEGKIVdakTIFTGHTAVVEDVSWHllHESLFGSVA-DDQ 250
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDV----ETGKCL---TTLRGHTDWVNSVAFS--PDGTFVASSsQDG 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 251 KLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNE 330
Cdd:cd00200 158 TIKLWDLR---TGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY 232

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47086813 331 tILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWViCSVSEDNIMQVWQ 403
Cdd:cd00200 233 -LLASGSEDGTIRVWDLRT--------------GECVQTLSGHTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 18-87 2.72e-33

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 119.61  E-value: 2.72e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47086813    18 EEYKIWKKNTPFLYDLVMTHALEWPSLTVQWLPDvnRPEGKDYVVHRLVLGTHTSD-EQNHLVIASAQIPN 87
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 169-348 1.39e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.18  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813  169 PDLRLRGHQKEGyGLSWNPNLSGNLLSASDDHTICLWDISgapkEGKIVdakTIFTGHTAVVEDVSWHLLHESLFGSVAD 248
Cdd:PLN00181 525 PVVELASRSKLS-GICWNSYIKSQVASSNFEGVVQVWDVA----RSQLV---TEMKEHEKRVWSIDYSSADPTLLASGSD 596

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813  249 DQKLMIWDTR---SNNTSKPShsvdahtAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW 325
Cdd:PLN00181 597 DGSVKLWSINqgvSIGTIKTK-------ANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF 669

                        170       180
                 ....*....|....*....|...
gi 47086813  326 SphNETILASSGTDRRLNVWDLS 348
Cdd:PLN00181 670 V--DSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 262-302 2.84e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.84e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 47086813    262 TSKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 302
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
263-302 2.03e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.03e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47086813   263 SKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 302
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
172-405 5.48e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 5.48e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 172 RLRGHQKEGYGLSWNPNlsGNLL-SASDDHTICLWDIsgapKEGKIVdakTIFTGHTAVVEDVSWHLlHESLFGSVADDQ 250
Cdd:COG2319 157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDL----ATGKLL---RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 251 KLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 330
Cdd:COG2319 227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47086813 331 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 405
Cdd:COG2319 301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-403 1.11e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.15  E-value: 1.11e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 172 RLRGHQKEGYGLSWNPNLSgNLLSASDDHTICLWDIsgapKEGKIVdakTIFTGHTAVVEDVSWHllHESLFGSVA-DDQ 250
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDV----ETGKCL---TTLRGHTDWVNSVAFS--PDGTFVASSsQDG 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 251 KLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNE 330
Cdd:cd00200 158 TIKLWDLR---TGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY 232

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47086813 331 tILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWViCSVSEDNIMQVWQ 403
Cdd:cd00200 233 -LLASGSEDGTIRVWDLRT--------------GECVQTLSGHTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 18-87 2.72e-33

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 119.61  E-value: 2.72e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47086813    18 EEYKIWKKNTPFLYDLVMTHALEWPSLTVQWLPDvnRPEGKDYVVHRLVLGTHTSD-EQNHLVIASAQIPN 87
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
WD40 COG2319
WD40 repeat [General function prediction only];
172-405 3.33e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 3.33e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 172 RLRGHQKEGYGLSWNPNlsGN-LLSASDDHTICLWDISGapkeGKIVdakTIFTGHTAVVEDVSWHLLHESLFgSVADDQ 250
Cdd:COG2319 115 TLTGHTGAVRSVAFSPD--GKtLASGSADGTVRLWDLAT----GKLL---RTLTGHSGAVTSVAFSPDGKLLA-SGSDDG 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 251 KLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 330
Cdd:COG2319 185 TVRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSP-DG 258

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47086813 331 TILASSGTDRRLNVWDLSkigeeqsaedaedgPPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 405
Cdd:COG2319 259 RLLASGSADGTVRLWDLA--------------TGELLRTLTGHSGGVNSVAFSPDGKLLA-SGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 173-406 1.59e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 1.59e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 173 LRGHQKEGYGLSWNPNlSGNLLSASDDHTICLWDISGapkegkiVDAKTIFTGHTAVVEDVSWHLLHESLFgSVADDQKL 252
Cdd:cd00200   5 LKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLET-------GELLRTLKGHTGPVRDVAASADGTYLA-SGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 253 MIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLKlHSFESHKDEIFQVQWSPHNeTI 332
Cdd:cd00200  76 RLWDL---ETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCL-TTLRGHTDWVNSVAFSPDG-TF 149

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47086813 333 LASSGTDRRLNVWDLSKIGEEQSAEdaedgppellfihgGHTAKISDFSWNPNEPWVICSvSEDNIMQVWQMAE 406
Cdd:cd00200 150 VASSSQDGTIKLWDLRTGKCVATLT--------------GHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
172-348 1.81e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 1.81e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 172 RLRGHQKEGYGLSWNPNlsGNLL-SASDDHTICLWDISGapkeGKIVdakTIFTGHTAVVEDVSWHLLHESLFgSVADDQ 250
Cdd:COG2319 241 TLTGHSGSVRSVAFSPD--GRLLaSGSADGTVRLWDLAT----GELL---RTLTGHSGGVNSVAFSPDGKLLA-SGSDDG 310

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 251 KLMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 330
Cdd:COG2319 311 TVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVAFSP-DG 384

                       170
                ....*....|....*...
gi 47086813 331 TILASSGTDRRLNVWDLS 348
Cdd:COG2319 385 RTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
171-405 1.01e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 1.01e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 171 LRLRGHQKEGYGLSWNPnLSGNLLSASDDHTICLWDISGAPkegkivdAKTIFTGHTAVVEDVSWHLLHESLfGSVADDQ 250
Cdd:COG2319  30 LLLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGA-------LLATLLGHTAAVLSVAFSPDGRLL-ASASADG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 251 KLMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPhNE 330
Cdd:COG2319 101 TVRLWDL---ATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKL-LRTLTGHSGAVTSVAFSP-DG 174

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47086813 331 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQVWQMA 405
Cdd:COG2319 175 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 265-405 2.28e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 2.28e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 265 PSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWDLRNLKLkLHSFESHKDEIFQVQWSPHNETiLASSGTDRRLNV 344
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGEL-LRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRL 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47086813 345 WDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVICSvSEDNIMQVWQMA 405
Cdd:cd00200  78 WDLET--------------GECVRTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
172-305 1.11e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 1.11e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 172 RLRGHQKEGYGLSWNPNlsGNLL-SASDDHTICLWDISgapkEGKIVdakTIFTGHTAVVEDVSWHLLHESLFgSVADDQ 250
Cdd:COG2319 283 TLTGHSGGVNSVAFSPD--GKLLaSGSDDGTVRLWDLA----TGKLL---RTLTGHTGAVRSVAFSPDGKTLA-SGSDDG 352

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47086813 251 KLMIWDTrsnNTSKPSHSVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRN 305
Cdd:COG2319 353 TVRLWDL---ATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 169-348 1.39e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.18  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813  169 PDLRLRGHQKEGyGLSWNPNLSGNLLSASDDHTICLWDISgapkEGKIVdakTIFTGHTAVVEDVSWHLLHESLFGSVAD 248
Cdd:PLN00181 525 PVVELASRSKLS-GICWNSYIKSQVASSNFEGVVQVWDVA----RSQLV---TEMKEHEKRVWSIDYSSADPTLLASGSD 596

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813  249 DQKLMIWDTR---SNNTSKPShsvdahtAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW 325
Cdd:PLN00181 597 DGSVKLWSINqgvSIGTIKTK-------ANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF 669

                        170       180
                 ....*....|....*....|...
gi 47086813  326 SphNETILASSGTDRRLNVWDLS 348
Cdd:PLN00181 670 V--DSSTLVSSSTDNTLKLWDLS 690
PTZ00420 PTZ00420
coronin; Provisional
 265-347 2.73e-10

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 62.27  E-value: 2.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813  265 PSHSVDAHTAEVNCLSFNP-YSEfILATGSADKTVALWDLRN-------LKLKLHSFESHKDEIFQVQWSPHNETILASS 336
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPcFSE-ILASGSEDLTIRVWEIPHndesvkeIKDPQCILKGHKKKISIIDWNPMNYYIMCSS 144

                         90
                 ....*....|.
gi 47086813  337 GTDRRLNVWDL 347
Cdd:PTZ00420 145 GFDSFVNIWDI 155
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-302 2.82e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 2.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 123 HEGEVNrarympqnpciiatktptsdvlafdytkhpskpdpsgdcspdlrlrghqkegyGLSWNPNlSGNLLSASDDHTI 202
Cdd:cd00200 176 HTGEVN-----------------------------------------------------SVAFSPD-GEKLLSSSSDGTI 201

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813 203 CLWDISGApkegkivDAKTIFTGHTAVVEDVSWHlLHESLFGSVADDQKLMIWDTRsnnTSKPSHSVDAHTAEVNCLSFN 282
Cdd:cd00200 202 KLWDLSTG-------KCLGTLRGHENGVNSVAFS-PDGYLLASGSEDGTIRVWDLR---TGECVQTLSGHTNSVTSLAWS 270

                       170       180
                ....*....|....*....|
gi 47086813 283 PySEFILATGSADKTVALWD 302
Cdd:cd00200 271 P-DGKRLASGSADGTIRIWD 289
PTZ00420 PTZ00420
coronin; Provisional
 161-307 5.70e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.96  E-value: 5.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813  161 PDPSGDCSPDLRLRGHQKEGYGLSwnpnlsgnllsASDDHTICLWDISGAPKEGKIVDAKTI-------FTGHTAVVEDV 233
Cdd:PTZ00420  12 PDPSNNLFDDLRICSRVIDSCGIA-----------CSSGFVAVPWEVEGGGLIGAIRLENQMrkppvikLKGHTSSILDL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47086813  234 SWHLLHESLFGSVADDQKLMIWDTRSNNTS-----KPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 307
Cdd:PTZ00420  81 QFNPCFSEILASGSEDLTIRVWEIPHNDESvkeikDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
PTZ00420 PTZ00420
coronin; Provisional
 306-407 2.26e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 53.03  E-value: 2.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813  306 LKLKlhsfeSHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKigEEQSAEDAEDGppelLFIHGGHTAKISDFSWNPN 385
Cdd:PTZ00420  68 IKLK-----GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPH--NDESVKEIKDP----QCILKGHKKKISIIDWNPM 136

                         90       100
                 ....*....|....*....|..
gi 47086813  386 EPWVICSVSEDNIMQVWQMaEN 407
Cdd:PTZ00420 137 NYYIMCSSGFDSFVNIWDI-EN 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 262-302 2.84e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.84e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 47086813    262 TSKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 302
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 214-346 1.79e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.89  E-value: 1.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813  214 GKIVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTR----SNNTSKPSHSVDAHTAEVNCLSFNPYSEFIL 289
Cdd:PTZ00421  62 GKLASNPPILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMNVL 141

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 47086813  290 ATGSADKTVALWDLRNLKLKlHSFESHKDEIFQVQWSPHNeTILASSGTDRRLNVWD 346
Cdd:PTZ00421 142 ASAGADMVVNVWDVERGKAV-EVIKCHSDQITSLEWNLDG-SLLCTTSKDKKLNIID 196
WD40 pfam00400
WD domain, G-beta repeat;
263-302 2.03e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.03e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 47086813   263 SKPSHSVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 302
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 119-306 2.66e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 2.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813  119 IKINHEGEVNRARYMPQNPCIIATKTPTSDVLAFDYtkhPSKPDPSGDCSPDLRLRGHQKEGYGLSWNPNLSGNLLSASD 198
Cdd:PTZ00421  70 ILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGI---PEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGA 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813  199 DHTICLWDIsgapKEGKivdAKTIFTGHTAVVEDVSWHlLHESLFGSVADDQKLMIWDTRSnntSKPSHSVDAH--TAEV 276
Cdd:PTZ00421 147 DMVVNVWDV----ERGK---AVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRD---GTIVSSVEAHasAKSQ 215

                        170       180       190
                 ....*....|....*....|....*....|...
gi 47086813  277 NCLsFNPYSEFILATG---SADKTVALWDLRNL 306
Cdd:PTZ00421 216 RCL-WAKRKDLIITLGcskSQQRQIMLWDTRKM 247
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 310-346 5.86e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.86e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 47086813    310 LHSFESHKDEIFQVQWSPHNeTILASSGTDRRLNVWD 346
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-206 2.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.06e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 47086813    173 LRGHQKEGYGLSWNPNlSGNLLSASDDHTICLWD 206
Cdd:smart00320   8 LKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 279-401 3.25e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086813  279 LSFNPYSEFILATGSADKTVALWDL------RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK--I 350
Cdd:PTZ00421  81 VAFNPFDPQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERgkA 160

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 47086813  351 GEEQSAedaedgppellfihggHTAKISDFSWNPNEPwVICSVSEDNIMQV 401
Cdd:PTZ00421 161 VEVIKC----------------HSDQITSLEWNLDGS-LLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
310-346 4.73e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 4.73e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 47086813   310 LHSFESHKDEIFQVQWSPhNETILASSGTDRRLNVWD 346
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
173-206 2.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 47086813   173 LRGHQKEGYGLSWNPNlSGNLLSASDDHTICLWD 206
Cdd:pfam00400   7 LEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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