|
Name |
Accession |
Description |
Interval |
E-value |
| iodotyrosine_dehalogenase |
cd02144 |
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ... |
93-285 |
3.27e-121 |
|
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.
Pssm-ID: 380320 Cd Length: 192 Bit Score: 344.52 E-value: 3.27e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 93 FYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTD 172
Cdd:cd02144 1 FYELMKKRRSVRDFSSEPVPREVIENAIRTAGTAPSGANTQPWTFVVVSDPEIKRKIREAAEEEEKEFYEKRMGEEWVWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 173 LKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNcGPRLRVLLG 252
Cdd:cd02144 81 LKPLGTNWEKPYLTEAPYLIVVFKQKYGVLPDGKKKKHYYNEESVGIAVGILLAALHNAGLVTLTHTPSP-MPFLRDLLG 159
|
170 180 190
....*....|....*....|....*....|...
gi 42794271 253 RPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQI 285
Cdd:cd02144 160 RPKNEKPLLLLPVGYPAEDATVPDLKRKPLEEI 192
|
|
| NfnB |
COG0778 |
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ... |
93-285 |
2.40e-33 |
|
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation
Pssm-ID: 440541 [Multi-domain] Cd Length: 163 Bit Score: 119.57 E-value: 2.40e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 93 FYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKiieeeeeinYMKRMGHRWVTD 172
Cdd:COG0778 1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAE---------ALAEANQEWVAD 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 173 lkklrtnwikeyldtAPILILIFKQVHgfaaNGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNcGPRLRVLLG 252
Cdd:COG0778 72 ---------------APVLIVVCADPD----RSEKVPERYALLDAGIAAQNLLLAARALGLGTCWIGGFD-PEKVRELLG 131
|
170 180 190
....*....|....*....|....*....|...
gi 42794271 253 RPAHEKLLMLLPVGYPSKEatVPDLKRKPLDQI 285
Cdd:COG0778 132 LPEGEEPVALLALGYPAEE--LNPRPRKPLEEV 162
|
|
| Nitroreductase |
pfam00881 |
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ... |
97-267 |
7.54e-19 |
|
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.
Pssm-ID: 425926 [Multi-domain] Cd Length: 168 Bit Score: 81.67 E-value: 7.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 97 LNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINymKRMGHRWVTDLKKL 176
Cdd:pfam00881 1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVE--PAAALLLLLRRDAN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 177 RTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNcGPRLRVLLGRPAH 256
Cdd:pfam00881 79 LKLLLQDFLRGAPVLIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFD-AAAVRELLGLPDD 157
|
170
....*....|.
gi 42794271 257 EKLLMLLPVGY 267
Cdd:pfam00881 158 ERLVGLIAVGY 168
|
|
| BluB |
TIGR02476 |
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in ... |
93-280 |
1.19e-10 |
|
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in cobalamin biosynthesis, is EC 1.16.8.1 (cob(II)yrinic acid a,c-diamide reductase) is now contradicted by newer work ascribing a role in 5,6-dimethylbenzimidazole (DMB) biosynthesis. The BluB protein is related to the nitroreductase family (pfam0881). [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Pssm-ID: 162875 Cd Length: 205 Bit Score: 59.76 E-value: 1.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 93 FYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEInYMKRMGHRWVTD 172
Cdd:TIGR02476 9 VYRLIRERRDVRHFRSDPVPEAVLERLLDAAHHAPSVGFSQPWRFVRVESPATREAVHALFTRANQA-AAAIYDGERASQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 173 LKKLRTNWIKEyldtAPILILIF-----KQVHGFAANGKKKVHYYneiSVSIACGILLAALQNAGL----VTVTTTplnc 243
Cdd:TIGR02476 88 YHRLKLEGIRE----APVQLAVFcddarGEGHGLGRHTMPEMLRY---SVACAIQNLWLAARAEGLgvgwVSILDP---- 156
|
170 180 190
....*....|....*....|....*....|....*..
gi 42794271 244 gPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRK 280
Cdd:TIGR02476 157 -DAVRRLLGVPEGWRLVAYLCLGWPDAFYDEPELERA 192
|
|
| PRK13294 |
PRK13294 |
F420-0--gamma-glutamyl ligase; Provisional |
100-173 |
1.52e-08 |
|
F420-0--gamma-glutamyl ligase; Provisional
Pssm-ID: 183957 [Multi-domain] Cd Length: 448 Bit Score: 55.02 E-value: 1.52e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42794271 100 RRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIrkiieeeeeinyMKRMGHRWVTDL 173
Cdd:PRK13294 260 RRSVREFSDDPVDPEAVRRAVAAALTAPAPHHTRPVRFVWLRSAAVRTRL------------LDAMRDAWRADL 321
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| iodotyrosine_dehalogenase |
cd02144 |
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ... |
93-285 |
3.27e-121 |
|
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.
Pssm-ID: 380320 Cd Length: 192 Bit Score: 344.52 E-value: 3.27e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 93 FYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTD 172
Cdd:cd02144 1 FYELMKKRRSVRDFSSEPVPREVIENAIRTAGTAPSGANTQPWTFVVVSDPEIKRKIREAAEEEEKEFYEKRMGEEWVWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 173 LKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNcGPRLRVLLG 252
Cdd:cd02144 81 LKPLGTNWEKPYLTEAPYLIVVFKQKYGVLPDGKKKKHYYNEESVGIAVGILLAALHNAGLVTLTHTPSP-MPFLRDLLG 159
|
170 180 190
....*....|....*....|....*....|...
gi 42794271 253 RPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQI 285
Cdd:cd02144 160 RPKNEKPLLLLPVGYPAEDATVPDLKRKPLEEI 192
|
|
| NfnB |
COG0778 |
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ... |
93-285 |
2.40e-33 |
|
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation
Pssm-ID: 440541 [Multi-domain] Cd Length: 163 Bit Score: 119.57 E-value: 2.40e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 93 FYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKiieeeeeinYMKRMGHRWVTD 172
Cdd:COG0778 1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAE---------ALAEANQEWVAD 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 173 lkklrtnwikeyldtAPILILIFKQVHgfaaNGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNcGPRLRVLLG 252
Cdd:COG0778 72 ---------------APVLIVVCADPD----RSEKVPERYALLDAGIAAQNLLLAARALGLGTCWIGGFD-PEKVRELLG 131
|
170 180 190
....*....|....*....|....*....|...
gi 42794271 253 RPAHEKLLMLLPVGYPSKEatVPDLKRKPLDQI 285
Cdd:COG0778 132 LPEGEEPVALLALGYPAEE--LNPRPRKPLEEV 162
|
|
| Nitro_FMN_reductase |
cd02062 |
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ... |
97-267 |
1.04e-21 |
|
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.
Pssm-ID: 380311 [Multi-domain] Cd Length: 139 Bit Score: 88.51 E-value: 1.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 97 LNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKiieeeeeinymkrmghrwvtdlkkl 176
Cdd:cd02062 1 IKTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLAK------------------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 177 RTNWIKEYLDTAPILILIFkqvhgfaANGKKKVHYYnEISVSIACGILLAALQNAGLVTVTTTPLNCG-PRLRVLLGRPA 255
Cdd:cd02062 56 LAAPNQKFIAGAPVVIVVV-------ADPDKSRPWA-LEDAGAAAQNLLLAAAALGLGSCWIGGFDFReDKVRELLGIPE 127
|
170
....*....|..
gi 42794271 256 HEKLLMLLPVGY 267
Cdd:cd02062 128 NLRPVALIAIGY 139
|
|
| Nitroreductase |
pfam00881 |
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ... |
97-267 |
7.54e-19 |
|
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.
Pssm-ID: 425926 [Multi-domain] Cd Length: 168 Bit Score: 81.67 E-value: 7.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 97 LNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINymKRMGHRWVTDLKKL 176
Cdd:pfam00881 1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVE--PAAALLLLLRRDAN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 177 RTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNcGPRLRVLLGRPAH 256
Cdd:pfam00881 79 LKLLLQDFLRGAPVLIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFD-AAAVRELLGLPDD 157
|
170
....*....|.
gi 42794271 257 EKLLMLLPVGY 267
Cdd:pfam00881 158 ERLVGLIAVGY 168
|
|
| nitroreductase |
cd02139 |
nitroreductase family protein; A subfamily of the nitroreductase family containing ... |
93-285 |
1.82e-17 |
|
nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.
Pssm-ID: 380316 [Multi-domain] Cd Length: 165 Bit Score: 77.90 E-value: 1.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 93 FYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKiieeeeeinymKRMGHRWVTD 172
Cdd:cd02139 1 VYEAIKKRRSIRKYKPTPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDKELKEKLAE-----------AANGQKFIAE 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 173 lkklrtnwikeyldtAPILI-LIFKQVHGFAANGKKkvhyYNEISVSIACG-ILLAAlQNAGLVTvtttplnC------G 244
Cdd:cd02139 70 ---------------APVVIvACADPSESGMGCGKP----YYLVDVAIAMEhLVLAA-TEEGLGT-------CwigafdE 122
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 42794271 245 PRLRVLLGRPAHEKLLMLLPVGYPSKEatVPDLKRKPLDQI 285
Cdd:cd02139 123 DKVKEILGIPEEYRVVALTPLGYPAEE--PPPRPRKPLEEI 161
|
|
| nitroreductase |
cd02151 |
nitroreductase family protein; A subfamily of the nitroreductase family containing ... |
95-271 |
1.90e-16 |
|
nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..
Pssm-ID: 380326 [Multi-domain] Cd Length: 157 Bit Score: 74.88 E-value: 1.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 95 ELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKiieeeeeinyMKRMGhrwvtdlk 174
Cdd:cd02151 1 ELLKKRRSIRKYTDEPIEEEKLEEILEAALLAPSSRNSRPVEFIVVDDKETLKKLSE----------CKPHG-------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 175 klrtnwiKEYLDTAPILILIfkqvhgfAANgKKKVHYYNEISvSIACGILLAALQNAGLVT--------VTTTPLNCGPR 246
Cdd:cd02151 63 -------SAFLKGAPAAIVV-------LAD-TEKSDTWIEDA-SIAATYIQLAAESLGLGScwiqirnrETQDGKTAEEY 126
|
170 180
....*....|....*....|....*
gi 42794271 247 LRVLLGRPAHEKLLMLLPVGYPSKE 271
Cdd:cd02151 127 VRELLGIPENYRVLCIIALGYPDEE 151
|
|
| MhqN-like |
cd02137 |
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ... |
95-285 |
1.13e-15 |
|
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.
Pssm-ID: 380314 [Multi-domain] Cd Length: 147 Bit Score: 72.27 E-value: 1.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 95 ELLNKRRSVR-FISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIeeeeeinymkrMGHRWVTdl 173
Cdd:cd02137 2 EVIKSRRSVRnFDPDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEAA-----------YNQPQVT-- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 174 kklrtnwikeyldTAPILILIFKQvhgfaangkkkvhyyneISVSIACGILLAALQNAGLVTVTTTPLNcGPRLRVLLGR 253
Cdd:cd02137 69 -------------TASAVILVLGD-----------------LNAGLAAMNLMLAAKAKGYDTCPMGGFD-KEKVAELLNL 117
|
170 180 190
....*....|....*....|....*....|..
gi 42794271 254 PAHEKLLMLLPVGYPSKEAtvPDLKRKPLDQI 285
Cdd:cd02137 118 PDRYVPVLLIAIGKAADKA--PRSGRLPVDEV 147
|
|
| nitroreductase |
cd20609 |
nitroreductase family protein; A subfamily of the nitroreductase family containing ... |
92-267 |
1.79e-14 |
|
nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.
Pssm-ID: 380330 [Multi-domain] Cd Length: 145 Bit Score: 68.95 E-value: 1.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 92 EFYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIieeeeeinymkrmghrwvt 171
Cdd:cd20609 1 DFLELAKKRYSVRKFSDKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEKLAKA------------------- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 172 dlkklrTNWIKEyldtAPILILIFKqVHGFAANGKKKVHYYNEISVSIACG-ILLAAlQNAGLVT--VtttplnCG---P 245
Cdd:cd20609 62 ------TPRFFG----APLVIVVCY-DKDESWKRPYDGKDSGDIDAAIVAThMMLAA-TELGLGTcwV------GNfdpE 123
|
170 180
....*....|....*....|..
gi 42794271 246 RLRVLLGRPAHEKLLMLLPVGY 267
Cdd:cd20609 124 KVREAFNLPENLEPVAILPLGY 145
|
|
| PnbA_NfnB-like |
cd02136 |
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ... |
96-285 |
2.82e-13 |
|
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.
Pssm-ID: 380313 [Multi-domain] Cd Length: 152 Bit Score: 66.07 E-value: 2.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 96 LLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPdvkhkirkiieeeeEINYMKRMGHrwvtdlkk 175
Cdd:cd02136 1 AIKSRRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTGK--------------ARERLKKAFF-------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 176 lrtnwikeyldTAPILILIFkqvhgfaanGKKKVHYYNEISVSIACGILLAALQNAGLVTVtttPLNCGPR----LRVLL 251
Cdd:cd02136 59 -----------GAPVALFLT---------MDKVLGPWSWFDLGAFLQNLMLAAHALGLGTC---PQGALAGypdvVRKEL 115
|
170 180 190
....*....|....*....|....*....|....*.
gi 42794271 252 GRPAHEKLLMLLPVGYPSKEATVPDL--KRKPLDQI 285
Cdd:cd02136 116 GIPDDEELVCGIALGYPDPDAPVNQFrtPREPLEEF 151
|
|
| nitroreductase |
cd03370 |
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ... |
95-271 |
1.28e-12 |
|
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.
Pssm-ID: 380327 [Multi-domain] Cd Length: 191 Bit Score: 65.03 E-value: 1.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 95 ELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIeeeeeinymkrMGHRWVTdlk 174
Cdd:cd03370 3 EAIESRRSIRKYTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEQLQAAA-----------YGQAQVT--- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 175 klrtnwikeyldTAPILILIFKQ-----------VH-GFAANGKKKV-----HYYNEISVS-----------IACGILLA 226
Cdd:cd03370 69 ------------SAPAVIVIYSDmedalanleetIHpGLSEERRQREaaglrGAFGKMSVEqrgqwglaqanIALGFLLL 136
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 42794271 227 ALQNAGLVTVTTTPLNCGpRLRVLLGRPAHEKLLMLLPVGYPSKE 271
Cdd:cd03370 137 AAQSLGYDTSPMLGFDPE-KVKALLGLPEHVTIAALVALGKPAEE 180
|
|
| nitroreductase |
cd02150 |
nitroreductase family protein; A subfamily of the nitroreductase family containing ... |
99-276 |
3.98e-12 |
|
nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.
Pssm-ID: 380325 [Multi-domain] Cd Length: 156 Bit Score: 63.00 E-value: 3.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 99 KRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEeeeeinYMKrmghrwvtdlkklrt 178
Cdd:cd02150 3 TRRSIRKYTDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVTDREKLDKIAEAHP------YGK--------------- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 179 nwikeYLDTAPILILIfkqvhgfAANGKK-KVHYYNEISVSIAC-GILLAAlQNAGLVTVTTtplNCGPR------LRVL 250
Cdd:cd02150 62 -----MLKEAPLAIVV-------CGDPSKeKAPGYWVQDCSAATeNILLAA-HALGLGAVWL---GVYPFeervkaIREI 125
|
170 180
....*....|....*....|....*.
gi 42794271 251 LGRPAHEKLLMLLPVGYPSKEATVPD 276
Cdd:cd02150 126 LNIPENIIPFCVIALGYPAEEKEPKD 151
|
|
| BluB |
TIGR02476 |
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in ... |
93-280 |
1.19e-10 |
|
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in cobalamin biosynthesis, is EC 1.16.8.1 (cob(II)yrinic acid a,c-diamide reductase) is now contradicted by newer work ascribing a role in 5,6-dimethylbenzimidazole (DMB) biosynthesis. The BluB protein is related to the nitroreductase family (pfam0881). [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Pssm-ID: 162875 Cd Length: 205 Bit Score: 59.76 E-value: 1.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 93 FYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEInYMKRMGHRWVTD 172
Cdd:TIGR02476 9 VYRLIRERRDVRHFRSDPVPEAVLERLLDAAHHAPSVGFSQPWRFVRVESPATREAVHALFTRANQA-AAAIYDGERASQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 173 LKKLRTNWIKEyldtAPILILIF-----KQVHGFAANGKKKVHYYneiSVSIACGILLAALQNAGL----VTVTTTplnc 243
Cdd:TIGR02476 88 YHRLKLEGIRE----APVQLAVFcddarGEGHGLGRHTMPEMLRY---SVACAIQNLWLAARAEGLgvgwVSILDP---- 156
|
170 180 190
....*....|....*....|....*....|....*..
gi 42794271 244 gPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRK 280
Cdd:TIGR02476 157 -DAVRRLLGVPEGWRLVAYLCLGWPDAFYDEPELERA 192
|
|
| BluB |
cd02145 |
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5, ... |
94-280 |
2.41e-10 |
|
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.
Pssm-ID: 380321 Cd Length: 196 Bit Score: 58.91 E-value: 2.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 94 YELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRwVTDL 173
Cdd:cd02145 1 YRVIRWRRDVRHFRPDPVPEEVLERLLQAAHLAPSVGLMQPWRFVRVRSAATRKAVHELFQRANAEAAEMYTGER-AAQY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 174 KKLRTnwikEYLDTAPILILIF-----KQVHGFAANGKKKVHYYneisvSIACGI----LLAALQNAGLVTVTTtpLNcg 244
Cdd:cd02145 80 RTLKL----EGIEEAPLQLAVFcdrarAGGHGLGRTTMPEMDLY-----SSVCAVqnlwLAARAEGLGVGWVSI--LD-- 146
|
170 180 190
....*....|....*....|....*....|....*..
gi 42794271 245 P-RLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRK 280
Cdd:cd02145 147 PdEVKRLLGIPEHWEPVAYLCIGYPEFFYDEPELEQA 183
|
|
| nitroreductase |
cd20610 |
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ... |
99-267 |
2.73e-10 |
|
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.
Pssm-ID: 380331 [Multi-domain] Cd Length: 167 Bit Score: 58.06 E-value: 2.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 99 KRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIrKIIEEEEEINYMKRMghRWVTDLKKLR- 177
Cdd:cd20610 3 KRRSIRKFKPDPVPKEDIEKILEAANWAPSGMNRQNWEFVVVKGGEKIEKI-GISIKKKNEEIARLL--EKVFAEKPIRf 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 178 TNWIK--EYLDTAPILILIFKQVHgfaangkKKVHYYNEISVSIAcgillAALQNAGLVTVT--------TTPLNCGPRL 247
Cdd:cd20610 80 RKFRRffTLFGGAPVLVVVYTEPY-------KPPEERKPDLQSVS-----AAIQNLLLAAHAlglgtcwmTGPLYAEDEI 147
|
170 180
....*....|....*....|
gi 42794271 248 RVLLGRPAHEKLLMLLPVGY 267
Cdd:cd20610 148 EEILEIPDDKELVAVTPLGY 167
|
|
| YdjA-like |
cd02135 |
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ... |
95-267 |
8.04e-09 |
|
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.
Pssm-ID: 380312 [Multi-domain] Cd Length: 162 Bit Score: 53.76 E-value: 8.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 95 ELLNKRRSVR-FISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVvkdpdVKHKIRKIIEEEEEINYMKRMGHRWVTDL 173
Cdd:cd02135 2 ELIKTRRSIRkFKLTGAPPEEQLEELLEAAMWAPNHGKLEPWRFIV-----VTGEGRERLAELLAAAAAARAPGADPEKL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 174 KKLRTNWIKeyldtAPILILIFKQVHGfaanGKKKVHYYNEISVSIAC-GILLAALQnAGLVTV-TTTPLNCGPRLRVLL 251
Cdd:cd02135 77 EKAREKALR-----APVVIAVVAKPDE----DPKVPEWEQYAAVGAAVqNLLLAAHA-LGLGAVwRTGPVTYDPAVREAL 146
|
170
....*....|....*.
gi 42794271 252 GRPAHEKLLMLLPVGY 267
Cdd:cd02135 147 GLPEDERIVGFLYLGT 162
|
|
| nitroreductase_FeS-like |
cd02143 |
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ... |
96-150 |
9.99e-09 |
|
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.
Pssm-ID: 380319 [Multi-domain] Cd Length: 187 Bit Score: 54.02 E-value: 9.99e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 42794271 96 LLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIR 150
Cdd:cd02143 1 LLRSRRSIRRYKDKPVPRETLEKLLDIARYAPTGHNSQPVHWLVVDDPEKVRRLA 55
|
|
| nitroreductase |
cd20608 |
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ... |
94-267 |
1.05e-08 |
|
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.
Pssm-ID: 380329 [Multi-domain] Cd Length: 145 Bit Score: 53.11 E-value: 1.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 94 YELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIieeeeeinymkrmghrwvtdl 173
Cdd:cd20608 1 FEAIKTRRSVRRFSDKPVEEEKLEKILEAARLAPSWANKQCWRFIVVTDKETLSELAKK--------------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 174 kklrTNWIKEYLDTAPILIlifkqvhgfAANGKKKV------HYYNEISVSIACGILLAALQNAGLVTVTTTPLNcGPRL 247
Cdd:cd20608 60 ----ESPSNGWLKDAPVII---------VVCADPKDsgwlngQNYYLVDAAIAMQNLMLAATDLGLGTCWIGAFD-EKKV 125
|
170 180
....*....|....*....|
gi 42794271 248 RVLLGRPAHEKLLMLLPVGY 267
Cdd:cd20608 126 KEILGIPENIRVVALTPLGY 145
|
|
| PRK13294 |
PRK13294 |
F420-0--gamma-glutamyl ligase; Provisional |
100-173 |
1.52e-08 |
|
F420-0--gamma-glutamyl ligase; Provisional
Pssm-ID: 183957 [Multi-domain] Cd Length: 448 Bit Score: 55.02 E-value: 1.52e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42794271 100 RRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIrkiieeeeeinyMKRMGHRWVTDL 173
Cdd:PRK13294 260 RRSVREFSDDPVDPEAVRRAVAAALTAPAPHHTRPVRFVWLRSAAVRTRL------------LDAMRDAWRADL 321
|
|
| TdsD-like |
cd02138 |
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ... |
96-285 |
2.62e-06 |
|
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.
Pssm-ID: 380315 [Multi-domain] Cd Length: 174 Bit Score: 46.77 E-value: 2.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 96 LLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKirkiieeeeeinymkrmghRWVTDLKK 175
Cdd:cd02138 1 LIAERWSPRAFSPEPISEEDLLSLFEAARWAPSCFNEQPWRFVVARRDTEAFE-------------------KLLDLLAE 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42794271 176 LRTNWIKEyldtAPILILIFKQVHgFAANGKKKVHYynEISVSIACGILLAALQNAGLVtvtttplnCGP-------RLR 248
Cdd:cd02138 62 GNQSWAKN----APVLIVVLAKTE-FDHNGKPNRYA--LFDTGAAVANLALQATALGLV--------VHQmagfdpeKAK 126
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 42794271 249 VLLGRPAHEKLLMLLPVGYPSKEATVPDL---------KRKPLDQI 285
Cdd:cd02138 127 EALGIPDEYEPITMIAIGYPGDPESLPEKllereeaprTRKPLSEI 172
|
|
| NfsB-like |
cd02149 |
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ... |
95-151 |
9.08e-06 |
|
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.
Pssm-ID: 380324 [Multi-domain] Cd Length: 156 Bit Score: 44.93 E-value: 9.08e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 42794271 95 ELLNKRRSVR-FISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRK 151
Cdd:cd02149 4 ELLNFRYATKkFDPNKKISDEDLETILEALRLSPSSFGLEPWKFLVVENPELKAKLAP 61
|
|
| NfsA-like |
cd02146 |
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ... |
95-149 |
9.16e-06 |
|
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.
Pssm-ID: 380322 [Multi-domain] Cd Length: 229 Bit Score: 45.69 E-value: 9.16e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 42794271 95 ELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKI 149
Cdd:cd02146 3 ETILNHRSVRKFTDEPLTDETLETLIAAAQSASTSSNLQAYSVIVVTDPELREKL 57
|
|
| |
