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Conserved domains on  [gi|30519913|ref|NP_848714|]
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COMM domain-containing protein 8 isoform a [Mus musculus]

Protein Classification

COMM domain-containing protein 8( domain architecture ID 10140836)

COMM domain-containing protein 8 (COMMD8) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and may also down-regulate activation of NF-kappa-B

Gene Symbol:  COMMD8
Gene Ontology:  GO:0005515
PubMed:  15799966

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 7-182 1.44e-87

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 254.64  E-value: 1.44e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30519913   7 TPLWRLQKLPPEQGAGLLHKIIDGFCGRAYPAHQDYHSVWNSAEWKHVLEDVTTFFKAVVGKNFSEEETLQQLNQLNSCH 86
Cdd:cd04756   1 TPPELINLLPVAQIVKLLHRVVDGVCGRAYPRYQDYSAIWSLEEWTEVLESLATLFKQAVGKNSNDEEAKAQLSDLSSSH 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30519913  87 QEAVLKCLKSRRNEIKQALLGEIVDISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDDKVKPYTVEMSKEELQ 166
Cdd:cd04756  81 QEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQLKLALSSDKLSSLQEPLLNLDLDVKENGILKPVSIEMNKEELQ 160

                       170
                ....*....|....*.
gi 30519913 167 SLISSLEAANKVVLQL 182
Cdd:cd04756 161 NLISSLEAANKVVLQL 176
 
Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 7-182 1.44e-87

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 254.64  E-value: 1.44e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30519913   7 TPLWRLQKLPPEQGAGLLHKIIDGFCGRAYPAHQDYHSVWNSAEWKHVLEDVTTFFKAVVGKNFSEEETLQQLNQLNSCH 86
Cdd:cd04756   1 TPPELINLLPVAQIVKLLHRVVDGVCGRAYPRYQDYSAIWSLEEWTEVLESLATLFKQAVGKNSNDEEAKAQLSDLSSSH 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30519913  87 QEAVLKCLKSRRNEIKQALLGEIVDISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDDKVKPYTVEMSKEELQ 166
Cdd:cd04756  81 QEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQLKLALSSDKLSSLQEPLLNLDLDVKENGILKPVSIEMNKEELQ 160

                       170
                ....*....|....*.
gi 30519913 167 SLISSLEAANKVVLQL 182
Cdd:cd04756 161 NLISSLEAANKVVLQL 176
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 113-175 1.48e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 64.88  E-value: 1.48e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30519913   113 SCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDD-KVKPYTVEMSKEELQSLISSLEAA 175
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDgSSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 7-182 1.44e-87

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 254.64  E-value: 1.44e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30519913   7 TPLWRLQKLPPEQGAGLLHKIIDGFCGRAYPAHQDYHSVWNSAEWKHVLEDVTTFFKAVVGKNFSEEETLQQLNQLNSCH 86
Cdd:cd04756   1 TPPELINLLPVAQIVKLLHRVVDGVCGRAYPRYQDYSAIWSLEEWTEVLESLATLFKQAVGKNSNDEEAKAQLSDLSSSH 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30519913  87 QEAVLKCLKSRRNEIKQALLGEIVDISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDDKVKPYTVEMSKEELQ 166
Cdd:cd04756  81 QEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQLKLALSSDKLSSLQEPLLNLDLDVKENGILKPVSIEMNKEELQ 160

                       170
                ....*....|....*.
gi 30519913 167 SLISSLEAANKVVLQL 182
Cdd:cd04756 161 NLISSLEAANKVVLQL 176
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 113-175 1.48e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 64.88  E-value: 1.48e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30519913   113 SCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDD-KVKPYTVEMSKEELQSLISSLEAA 175
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDgSSEEVTFELSKEQLQDLLNELEEA 64
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 93-179 1.35e-12

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 60.40  E-value: 1.35e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30519913  93 CLKSRRNEIKQALLGEivDISCAQLQDFDWQLKLALSSDKIATLQMP--LLNLHLDVKEDDKVKPYTVEMSKEELQSLIS 170
Cdd:cd04748   1 LLTENKAEIEELLSKQ--SLSLPQLVDFDWRLDVQISSSSLAKVKQPtiLVQLKLQVGDNNSSEKICFEMTKEELQNFLN 78


                ....*....
gi 30519913 171 SLEAANKVV 179
Cdd:cd04748  79 KLKKIKAQL 87
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 65-175 5.69e-05

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 41.65  E-value: 5.69e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30519913  65 VVGKNFSEEetLQQLNqLNSCHQEAVLKCLKSRRNEIKQALLGEIVDIScaQLQDFDWQLKLALSSDKIATLQMPLLNLH 144
Cdd:cd04752  60 VDGESLSSE--LQQLG-LPKEHATSLCRSYEEKQSKLQESLRANSLRLS--RLESVDWRVDYILSSSELQEVNEPLVQLR 134

                        90       100       110
                ....*....|....*....|....*....|...
gi 30519913 145 LDVK--EDDKVKPYTVEMSKEELQSLISSLEAA 175
Cdd:cd04752 135 LKVRnaDTGEITPHPFSVSADKFRVLLAELKQA 167
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 112-172 1.15e-04

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 39.86  E-value: 1.15e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30519913 112 ISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDDKVK-------PYTVEMSKEELQSLISSL 172
Cdd:cd04757  29 ISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQEAPSLCgllpplsTLTMELSKETLDTMLDGL 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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