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Conserved domains on  [gi|260166652|ref|NP_796104|]
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glycosyltransferase 28 domain containing 1-like [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PssE super family cl49515
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
4-153 2.46e-34

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


The actual alignment was detected with superfamily member NF041548:

Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 117.63  E-value: 2.46e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166652   4 VFVTVGTTSFDDLIARVvahDsvQILKNLGYNQLVLQIGRGTVVPEPFstESFtldvyRYKDSLKEDLQQADLVISHAGA 83
Cdd:NF041548   1 IFVTVGTTRFDSLIKAI---D--ELIEGLIDYEVTFQIGDGKYIPKNG--EYF-----DFLEEIDEYYKKADLIITHAGA 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 260166652  84 GSCLESLEKGKPLVVVVNEKLMNNHQFELAKQLHKEGHLFYCT-CSMLPELLQSMDLSTLKCYppgQPEKF 153
Cdd:NF041548  69 GTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVCYdLDELEDAIKEAENFKPNPY---EKNPF 136
 
Name Accession Description Interval E-value
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
4-153 2.46e-34

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 117.63  E-value: 2.46e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166652   4 VFVTVGTTSFDDLIARVvahDsvQILKNLGYNQLVLQIGRGTVVPEPFstESFtldvyRYKDSLKEDLQQADLVISHAGA 83
Cdd:NF041548   1 IFVTVGTTRFDSLIKAI---D--ELIEGLIDYEVTFQIGDGKYIPKNG--EYF-----DFLEEIDEYYKKADLIITHAGA 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 260166652  84 GSCLESLEKGKPLVVVVNEKLMNNHQFELAKQLHKEGHLFYCT-CSMLPELLQSMDLSTLKCYppgQPEKF 153
Cdd:NF041548  69 GTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVCYdLDELEDAIKEAENFKPNPY---EKNPF 136
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 4-120 1.21e-29

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 106.26  E-value: 1.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166652    4 VFVTVGTTSFDDLIARVVAHDSVQILKnlGYNQLVLQIGRGTVVPEPFSTESFTL--DVYRYKDSLKEDLQQADLVISHA 81
Cdd:pfam04101   2 ILVTGGSQGARALNELVLSVLPLLELK--GELQVLHQTGKGDLEEVKIDYAELGInyEVFPFIDNMAEYIKAADLVISRA 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 260166652   82 GAGSCLESLEKGKPLVVVVNEKLMNNHQFELAKQLHKEG 120
Cdd:pfam04101  80 GAGTIAELLALGKPAILVPNPSAARGHQDNNAKELVKAG 118
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
4-125 1.60e-19

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 79.97  E-value: 1.60e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166652   4 VFVTVGTT--SFDDLIArvvahdSVQILKNLGYNQ--LVLQIGRGTVVPEPFSTESFtLDvyryKDSLKEDLQQADLVIS 79
Cdd:COG5017    2 IFVTVGTHqlPFDRLVR------WVDELAAEGIIDeeVFVQTGHTTYVPRNAEAVPF-LP----PDEFQKLIAQARLVIS 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 260166652  80 HAGAGSCLESLEKGKPLVVVV-NEKL---MNNHQFELAKQLHKEGHLFYC 125
Cdd:COG5017   71 HAGMGSILTALKLGKPFILVPrLARYgehVDDHQLETARALEKLGGIIVV 120
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 2-120 5.45e-11

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 59.54  E-value: 5.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166652   2 KRVFVT---VGTTSFDDLIARVVAHdsvqiLKNLGYnQLVLQIGRG--TVVPEPFSTESFTLDVYRYKDSLKEDLQQADL 76
Cdd:cd03785  182 PTLLVFggsQGARAINRAVPKALPK-----LLERGI-QVIHQTGKGdyDEVKKLYEDLGINVKVFPFIDDMAAAYAAADL 255

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 260166652  77 VISHAGAGSCLESLEKGKPLVVVVNEKLMNNHQFELAKQLHKEG 120
Cdd:cd03785  256 VISRAGASTIAELTAAGKPAILIPYPYAADDHQEANARALEKAG 299
MGT TIGR01426
glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) ...
 36-99 2.87e-04

glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance]


Pssm-ID: 273616 [Multi-domain]  Cd Length: 392  Bit Score: 40.05  E-value: 2.87e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 260166652   36 QLVLQIGRGtVVPEPFSTESFTLDVYRYKDSLkEDLQQADLVISHAGAGSCLESLEKGKPLVVV 99
Cdd:TIGR01426 256 HVVLSVGRG-VDPADLGELPPNVEVRQWVPQL-EILKKADAFITHGGMNSTMEALFNGVPMVAV 317
 
Name Accession Description Interval E-value
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
4-153 2.46e-34

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 117.63  E-value: 2.46e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166652   4 VFVTVGTTSFDDLIARVvahDsvQILKNLGYNQLVLQIGRGTVVPEPFstESFtldvyRYKDSLKEDLQQADLVISHAGA 83
Cdd:NF041548   1 IFVTVGTTRFDSLIKAI---D--ELIEGLIDYEVTFQIGDGKYIPKNG--EYF-----DFLEEIDEYYKKADLIITHAGA 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 260166652  84 GSCLESLEKGKPLVVVVNEKLMNNHQFELAKQLHKEGHLFYCT-CSMLPELLQSMDLSTLKCYppgQPEKF 153
Cdd:NF041548  69 GTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVCYdLDELEDAIKEAENFKPNPY---EKNPF 136
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 4-120 1.21e-29

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 106.26  E-value: 1.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166652    4 VFVTVGTTSFDDLIARVVAHDSVQILKnlGYNQLVLQIGRGTVVPEPFSTESFTL--DVYRYKDSLKEDLQQADLVISHA 81
Cdd:pfam04101   2 ILVTGGSQGARALNELVLSVLPLLELK--GELQVLHQTGKGDLEEVKIDYAELGInyEVFPFIDNMAEYIKAADLVISRA 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 260166652   82 GAGSCLESLEKGKPLVVVVNEKLMNNHQFELAKQLHKEG 120
Cdd:pfam04101  80 GAGTIAELLALGKPAILVPNPSAARGHQDNNAKELVKAG 118
COG5017 COG5017
UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];
4-125 1.60e-19

UDP-N-acetylglucosamine transferase subunit ALG13 [Carbohydrate transport and metabolism];


Pssm-ID: 444041 [Multi-domain]  Cd Length: 164  Bit Score: 79.97  E-value: 1.60e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166652   4 VFVTVGTT--SFDDLIArvvahdSVQILKNLGYNQ--LVLQIGRGTVVPEPFSTESFtLDvyryKDSLKEDLQQADLVIS 79
Cdd:COG5017    2 IFVTVGTHqlPFDRLVR------WVDELAAEGIIDeeVFVQTGHTTYVPRNAEAVPF-LP----PDEFQKLIAQARLVIS 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 260166652  80 HAGAGSCLESLEKGKPLVVVV-NEKL---MNNHQFELAKQLHKEGHLFYC 125
Cdd:COG5017   71 HAGMGSILTALKLGKPFILVPrLARYgehVDDHQLETARALEKLGGIIVV 120
YjiC COG1819
UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];
2-120 2.46e-12

UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];


Pssm-ID: 441424 [Multi-domain]  Cd Length: 268  Bit Score: 62.95  E-value: 2.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166652   2 KRVFVTVGTTSFD--DLIARVVAhdsvqILKNLGYnQLVLQIGRgtVVPEPFSTESFTLDVYRYKDsLKEDLQQADLVIS 79
Cdd:COG1819  121 PLVYVTLGTSANDraDLLRAVLE-----ALADLGV-RVVVTTGG--LDPAELGPLPDNVRVVDYVP-QDALLPRADAVVH 191

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 260166652  80 HAGAGSCLESLEKGKPLVVVVneklMNNHQFELAKQLHKEG 120
Cdd:COG1819  192 HGGAGTTAEALRAGVPQVVVP----FGGDQPLNAARVERLG 228
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 2-120 5.45e-11

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 59.54  E-value: 5.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166652   2 KRVFVT---VGTTSFDDLIARVVAHdsvqiLKNLGYnQLVLQIGRG--TVVPEPFSTESFTLDVYRYKDSLKEDLQQADL 76
Cdd:cd03785  182 PTLLVFggsQGARAINRAVPKALPK-----LLERGI-QVIHQTGKGdyDEVKKLYEDLGINVKVFPFIDDMAAAYAAADL 255

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 260166652  77 VISHAGAGSCLESLEKGKPLVVVVNEKLMNNHQFELAKQLHKEG 120
Cdd:cd03785  256 VISRAGASTIAELTAAGKPAILIPYPYAADDHQEANARALEKAG 299
MGT TIGR01426
glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) ...
 36-99 2.87e-04

glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance]


Pssm-ID: 273616 [Multi-domain]  Cd Length: 392  Bit Score: 40.05  E-value: 2.87e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 260166652   36 QLVLQIGRGtVVPEPFSTESFTLDVYRYKDSLkEDLQQADLVISHAGAGSCLESLEKGKPLVVV 99
Cdd:TIGR01426 256 HVVLSVGRG-VDPADLGELPPNVEVRQWVPQL-EILKKADAFITHGGMNSTMEALFNGVPMVAV 317
MurG COG0707
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope ...
 12-120 1.18e-03

UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440471 [Multi-domain]  Cd Length: 363  Bit Score: 38.19  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260166652  12 SFDDLIARVVAHdsvqiLKNLGYnQLVLQIGRG---TVVPEPFSTESFTLDVYRYKDSLKEDLQQADLVISHAGAGSCLE 88
Cdd:COG0707  200 ALNEAVPAALAA-----LLEARL-QVVHQTGKGdyeEVRAAYAAAIRPNAEVFPFIDDMADAYAAADLVISRAGASTVAE 273

                         90       100       110
                 ....*....|....*....|....*....|..
gi 260166652  89 SLEKGKPLVVVVNEKLMNNHQFELAKQLHKEG 120
Cdd:COG0707  274 LAALGKPAILVPLPHAADDHQTKNARALVEAG 305
GT1_Gtf-like cd03784
UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of ...
 75-99 1.54e-03

UDP-glycosyltransferases and similar proteins; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.


Pssm-ID: 340817 [Multi-domain]  Cd Length: 404  Bit Score: 37.92  E-value: 1.54e-03
                         10        20
                 ....*....|....*....|....*
gi 260166652  75 DLVISHAGAGSCLESLEKGKPLVVV 99
Cdd:cd03784  309 GAFVTHGGWNSTLEALYAGVPMVVV 333
murG TIGR01133
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; RM 8449890 RT ...
 71-143 6.47e-03

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273460 [Multi-domain]  Cd Length: 348  Bit Score: 36.11  E-value: 6.47e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 260166652   71 LQQADLVISHAGAGSCLESLEKGKPLVVVVNEKlMNNHQFELAKQLHKEGhlfYCTC----SMLPELLQSMDLSTLK 143
Cdd:TIGR01133 248 YAAADLVISRAGASTVAELAAAGVPAILIPYPY-AADDQYYNAKFLEDLG---AGLVirqkELLPEKLLEALLKLLL 320
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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