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Conserved domains on  [gi|24664051|ref|NP_648688|]
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neuralized E3 ubiquitin protein ligase 4 [Drosophila melanogaster]

Protein Classification

SPRY_NHR_like domain-containing protein( domain architecture ID 10191474)

SPRY_NHR_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 467-629 1.04e-81

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 265.53  E-value: 1.04e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  467 TFHHICGTHATVTQSGRTALRPNaaDDFNNGVVLTRRPLRPNELFQVRLERVVTKWAGSVEMGVTTHSADELDFPFTMTN 546
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  547 VRSGTWMMTGNGVMQNGVTVIEQYGQNLDRLQVGDRVGVVRKDDGTLHFWVNGVDQGPAANNVPERVYGVIDLYGQAAQA 626
Cdd:cd12887   79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 24664051  627 SIV 629
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 8-168 1.75e-76

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 250.50  E-value: 1.75e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    8 SFHTRCGRSIRLYNNNRMAQRSMRDFSHALVFSAEPLEDDVLFEVVIEKKNTYWGGSIEIGVTAESPDDLELVACATAMR 87
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051   88 NGTWVMSGIDVRKDGRRLFEFYGTDLETLNENDRVGVMRTSGNDLVFYVNGESQGVAAKNMPKPLWALVDLYGRCVQVSL 167
Cdd:cd12887   81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                 .
gi 24664051  168 C 168
Cdd:cd12887  161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 225-387 7.49e-76

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 248.58  E-value: 7.49e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  225 FHTRCGSLVKLSPNFRSAERRRplDEFNNGVVMTHRPLRDNELFEIRIDKLVDKWSGSIEVGVTTHNPAVLHFPATMTNM 304
Cdd:cd12887    2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  305 RSGTIMMSGCGILTNGKGTRRQYGeFNLDELREGDRVGMMRKANGNLHNYINGQDQGVAATRAPSTLWGVIDLYGMTIKV 384
Cdd:cd12887   80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 24664051  385 TIV 387
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 656-818 8.36e-68

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 225.47  E-value: 8.36e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  656 RFHSIHGANAGISNSGLTASRPNSlaEFNDAIVFSNRPLRQRELFEVELETMVRHWSGNIEIGVTGTRPEDIQLAPNATD 735
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKA--SFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  736 LeASDTIILCGPMIFHNRKTIRTNILLDLDTLGPSTRVGVMRNGD-FIHFFVDGMDQGPACECHAPNIWAIIDLYGQCAQ 814
Cdd:cd12887   79 L-KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDgTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQ 157


                 ....
gi 24664051  815 VSLT 818
Cdd:cd12887  158 VSIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1063-1220 3.71e-47

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 166.53  E-value: 3.71e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051 1063 EFLDVSQKNARLSDDRRSVTRIK-SYNQSIVCLNKPLCKGESISIKVDALNNKWKGTVGLGVLSASPQT--VPISLLDFK 1139
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETldLPPSATDLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051 1140 RSCWLATHDYVNINGQVMPSKYGDALEQIQVGTVITLTLTHAGMLIIMIGSTNLEDLASGLPNHVYPVFDVYGKCEKITL 1219
Cdd:cd12887   81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                 .
gi 24664051 1220 I 1220
Cdd:cd12887  161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 854-1016 1.55e-40

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


:

Pssm-ID: 293945  Cd Length: 161  Bit Score: 147.66  E-value: 1.55e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  854 WTCVSGNVSLTKDWTEASRFtgaAAPLSHCLVFSEHPLSVGSPFEIKLTSVNSMFAGCLSIGVTDLNLSDEsvrkKLPTS 933
Cdd:cd12887    3 HENHGKNIRLSNDGRTATRV---KASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETL----DLPPS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  934 IRRIPANVWYVSGNEVCFNSSCLQRSL-ASLEWLRVDDRITLERV-ENSLNILLNSENVNIHFHNVPNDVYVVAELRGST 1011
Cdd:cd12887   76 ATDLKSGTWILSGSSVFKNGNKIRENYgPDLDRLRVGDRVGVMRTsDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQC 155


                 ....*
gi 24664051 1012 mgIQV 1016
Cdd:cd12887  156 --EQV 158
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 467-629 1.04e-81

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 265.53  E-value: 1.04e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  467 TFHHICGTHATVTQSGRTALRPNaaDDFNNGVVLTRRPLRPNELFQVRLERVVTKWAGSVEMGVTTHSADELDFPFTMTN 546
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  547 VRSGTWMMTGNGVMQNGVTVIEQYGQNLDRLQVGDRVGVVRKDDGTLHFWVNGVDQGPAANNVPERVYGVIDLYGQAAQA 626
Cdd:cd12887   79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 24664051  627 SIV 629
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 8-168 1.75e-76

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 250.50  E-value: 1.75e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    8 SFHTRCGRSIRLYNNNRMAQRSMRDFSHALVFSAEPLEDDVLFEVVIEKKNTYWGGSIEIGVTAESPDDLELVACATAMR 87
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051   88 NGTWVMSGIDVRKDGRRLFEFYGTDLETLNENDRVGVMRTSGNDLVFYVNGESQGVAAKNMPKPLWALVDLYGRCVQVSL 167
Cdd:cd12887   81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                 .
gi 24664051  168 C 168
Cdd:cd12887  161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 225-387 7.49e-76

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 248.58  E-value: 7.49e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  225 FHTRCGSLVKLSPNFRSAERRRplDEFNNGVVMTHRPLRDNELFEIRIDKLVDKWSGSIEVGVTTHNPAVLHFPATMTNM 304
Cdd:cd12887    2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  305 RSGTIMMSGCGILTNGKGTRRQYGeFNLDELREGDRVGMMRKANGNLHNYINGQDQGVAATRAPSTLWGVIDLYGMTIKV 384
Cdd:cd12887   80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 24664051  385 TIV 387
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 656-818 8.36e-68

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 225.47  E-value: 8.36e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  656 RFHSIHGANAGISNSGLTASRPNSlaEFNDAIVFSNRPLRQRELFEVELETMVRHWSGNIEIGVTGTRPEDIQLAPNATD 735
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKA--SFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  736 LeASDTIILCGPMIFHNRKTIRTNILLDLDTLGPSTRVGVMRNGD-FIHFFVDGMDQGPACECHAPNIWAIIDLYGQCAQ 814
Cdd:cd12887   79 L-KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDgTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQ 157


                 ....
gi 24664051  815 VSLT 818
Cdd:cd12887  158 VSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 225-388 1.91e-57

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 195.45  E-value: 1.91e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    225 FHTRCGSLVKLSPNFRSAERRRpldEFNNGVVMTHRPLRDNELFEIRIDKLVDKWSGSIEVGVTTHNPAVL---HFPATM 301
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkALPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    302 TNMRSGTIM--MSGCgiltngkgtrrqygefnldELREGDRVGMMRKANGNLHNYINGQDQGVAATRAPST--LWGVIDL 377
Cdd:pfam07177   78 TDLRPGYWVvaLSGS-------------------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDL 138

                          170
                   ....*....|.
gi 24664051    378 YGMTIKVTIVD 388
Cdd:pfam07177  139 YGQTTQVSILG 149
NEUZ smart00588
domain in neuralized proteins;
221-345 3.23e-54

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 185.21  E-value: 3.23e-54
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051     221 DRLCFHTRCGSLVKLSPNFRSAerRRPLDEFNNGVVMTHRPLRDNELFEIRIDKLVDKWSGSIEVGVTTHNPAVLHFPAT 300
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVA--RRSASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 24664051     301 MTNMRSGTIMMSGCGILTNGKGTRRQYGEFNLDELREGDRVGMMR 345
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGILGLDVLAEGEVVGVIN 123
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 468-630 8.97e-54

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 185.05  E-value: 8.97e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    468 FHHICGTHATVTQSGRTALRPNAaddFNNGVVLTRRPLRPNELFQVRLERVVTKWAGSVEMGVTTHSADEL---DFPFTM 544
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNS---FNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkALPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    545 TNVRSGTWMMTGNGvmqngvtvieqygqnlDRLQVGDRVGVVRKDDGTLHFWVNGVDQGPAANNVPER--VYGVIDLYGQ 622
Cdd:pfam07177   78 TDLRPGYWVVALSG----------------SYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*...
gi 24664051    623 AAQASIVD 630
Cdd:pfam07177  142 TTQVSILG 149
NEUZ smart00588
domain in neuralized proteins;
464-587 3.76e-50

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 173.65  E-value: 3.76e-50
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051     464 DRLTFHHICGTHATVTQSGRTALRPnaADDFNNGVVLTRRPLRPNELFQVRLERVVTKWAGSVEMGVTTHSADELDFPFT 543
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVARRS--ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 24664051     544 MTNVRSGTWMMTGNGVMQNGVTVIEQYG-QNLDRLQVGDRVGVVR 587
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 9-168 1.58e-49

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 172.72  E-value: 1.58e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051      9 FHTRCGRSIRLYNNNRMAQRSmRDFSHALVFSAEPLEDDVLFEVVIEKKNTYWGGSIEIGVTAESPDDLELVAC---ATA 85
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRT-NSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRPKALpdlATD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051     86 MRNGTWVMSgidvrKDGRrlfefygtdleTLNENDRVGVMRTSGNDLVFYVNGESQGVAAKNMP--KPLWALVDLYGRCV 163
Cdd:pfam07177   80 LRPGYWVVA-----LSGS-----------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQTT 143


                   ....*
gi 24664051    164 QVSLC 168
Cdd:pfam07177  144 QVSIL 148
NEUZ smart00588
domain in neuralized proteins;
5-126 7.24e-49

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 169.80  E-value: 7.24e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051       5 EAQSFHTRCGRSIRLYNNNRMAQRSMRDFSHALVFSAEPLEDDVLFEVVIEKKNTYWGGSIEIGVTAESPDDLELVACAT 84
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVARRSASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPT 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 24664051      85 AMRNGTWVMSGIDVRKDGRRLFEFYGT-DLETLNENDRVGVMR 126
Cdd:smart00588   81 NACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
653-777 2.84e-48

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 168.26  E-value: 2.84e-48
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051     653 VPLRFHSIHGANAGISNSGLTASRPnsLAEFNDAIVFSNRPLRQRELFEVELETMVRHWSGNIEIGVTGTRPEDIQLAPN 732
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVARRS--ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 24664051     733 ATDLEASDTIILCGPMIFHNRKTIRTNILLDLDTLGPSTRVGVMR 777
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGILGLDVLAEGEVVGVIN 123
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1063-1220 3.71e-47

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 166.53  E-value: 3.71e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051 1063 EFLDVSQKNARLSDDRRSVTRIK-SYNQSIVCLNKPLCKGESISIKVDALNNKWKGTVGLGVLSASPQT--VPISLLDFK 1139
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETldLPPSATDLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051 1140 RSCWLATHDYVNINGQVMPSKYGDALEQIQVGTVITLTLTHAGMLIIMIGSTNLEDLASGLPNHVYPVFDVYGKCEKITL 1219
Cdd:cd12887   81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                 .
gi 24664051 1220 I 1220
Cdd:cd12887  161 V 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 657-817 1.87e-43

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 155.39  E-value: 1.87e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    657 FHSIHGANAGISNSGLTASRPNSlaeFNDAIVFSNRPLRQRELFEVELETMVRHWSGNIEIGVTGTRPEDIQLA--PNAT 734
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNS---FNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRPKalPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    735 DLEASDTIILCgpmifhnrktirtnilLDLDTLGPSTRVGVMRNGD-FIHFFVDGMDQGPACECHAPN--IWAIIDLYGQ 811
Cdd:pfam07177   78 TDLRPGYWVVA----------------LSGSYLQEGDRLGFWVTSDgELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*.
gi 24664051    812 CAQVSL 817
Cdd:pfam07177  142 TTQVSI 147
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 854-1016 1.55e-40

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 147.66  E-value: 1.55e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  854 WTCVSGNVSLTKDWTEASRFtgaAAPLSHCLVFSEHPLSVGSPFEIKLTSVNSMFAGCLSIGVTDLNLSDEsvrkKLPTS 933
Cdd:cd12887    3 HENHGKNIRLSNDGRTATRV---KASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETL----DLPPS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  934 IRRIPANVWYVSGNEVCFNSSCLQRSL-ASLEWLRVDDRITLERV-ENSLNILLNSENVNIHFHNVPNDVYVVAELRGST 1011
Cdd:cd12887   76 ATDLKSGTWILSGSSVFKNGNKIRENYgPDLDRLRVGDRVGVMRTsDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQC 155


                 ....*
gi 24664051 1012 mgIQV 1016
Cdd:cd12887  156 --EQV 158
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 1064-1220 1.89e-20

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 89.52  E-value: 1.89e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051   1064 FLDVSQKNARLSDDRRSVTRIKSYNQSIVCLNKPLCKGESISIKVDALNNKWKGTVGLGVLSASPQTV-----PISLLDF 1138
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkalPDLATDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051   1139 KRSCWLAthdyvningqVMPSKYgdaleqIQVGTVITLTLTHAGMLIIMIGSTNLEDLASGLPNH--VYPVFDVYGKCEK 1216
Cdd:pfam07177   81 RPGYWVV----------ALSGSY------LQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQTTQ 144


                   ....
gi 24664051   1217 ITLI 1220
Cdd:pfam07177  145 VSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 860-1018 9.21e-10

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 58.70  E-value: 9.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    860 NVSLTKDWTEASRftgaAAPLSHCLVFSEHPLSVGSPFEIKLTSVNSMFAGCLSIGVTDLN---LSDesvrKKLPTSIRR 936
Cdd:pfam07177    8 NVRLSNDGRTARR----TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDpatLRP----KALPDLATD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    937 IPANVWYVSgnevcfnssclqrslASLEWLRVDDRITLERVEN-SLNILLNSENVNIHFHNVPN--DVYVVAELRGSTMG 1013
Cdd:pfam07177   80 LRPGYWVVA---------------LSGSYLQEGDRLGFWVTSDgELHFSVNGEDQGVALSGVPDsqPLWAVFDLYGQTTQ 144


                   ....*
gi 24664051   1014 IQVIS 1018
Cdd:pfam07177  145 VSILG 149
NEUZ smart00588
domain in neuralized proteins;
1071-1141 3.70e-06

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 47.69  E-value: 3.70e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24664051    1071 NARLSDDRRSVTRIKS-YNQSIVCLNKPLCKGESISIKVDALNNKWKGTVGLGVLSASPQTV-PISLLDFKRS 1141
Cdd:smart00588   12 NIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLrPASLPTNACP 84
NEUZ smart00588
domain in neuralized proteins;
860-920 4.08e-06

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 47.69  E-value: 4.08e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24664051     860 NVSLTKDWTEASRFtgaAAPLSHCLVFSEHPLSVGSPFEIKLTSVNSMFAGCLSIGVTDLN 920
Cdd:smart00588   12 NIRLSDSGRVARRS---ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCD 69
 
Name Accession Description Interval E-value
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 467-629 1.04e-81

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 265.53  E-value: 1.04e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  467 TFHHICGTHATVTQSGRTALRPNaaDDFNNGVVLTRRPLRPNELFQVRLERVVTKWAGSVEMGVTTHSADELDFPFTMTN 546
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  547 VRSGTWMMTGNGVMQNGVTVIEQYGQNLDRLQVGDRVGVVRKDDGTLHFWVNGVDQGPAANNVPERVYGVIDLYGQAAQA 626
Cdd:cd12887   79 LKSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 24664051  627 SIV 629
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 8-168 1.75e-76

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 250.50  E-value: 1.75e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    8 SFHTRCGRSIRLYNNNRMAQRSMRDFSHALVFSAEPLEDDVLFEVVIEKKNTYWGGSIEIGVTAESPDDLELVACATAMR 87
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051   88 NGTWVMSGIDVRKDGRRLFEFYGTDLETLNENDRVGVMRTSGNDLVFYVNGESQGVAAKNMPKPLWALVDLYGRCVQVSL 167
Cdd:cd12887   81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                 .
gi 24664051  168 C 168
Cdd:cd12887  161 V 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 225-387 7.49e-76

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 248.58  E-value: 7.49e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  225 FHTRCGSLVKLSPNFRSAERRRplDEFNNGVVMTHRPLRDNELFEIRIDKLVDKWSGSIEVGVTTHNPAVLHFPATMTNM 304
Cdd:cd12887    2 FHENHGKNIRLSNDGRTATRVK--ASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  305 RSGTIMMSGCGILTNGKGTRRQYGeFNLDELREGDRVGMMRKANGNLHNYINGQDQGVAATRAPSTLWGVIDLYGMTIKV 384
Cdd:cd12887   80 KSGTWILSGSSVFKNGNKIRENYG-PDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQV 158


                 ...
gi 24664051  385 TIV 387
Cdd:cd12887  159 SIV 161
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 656-818 8.36e-68

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 225.47  E-value: 8.36e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  656 RFHSIHGANAGISNSGLTASRPNSlaEFNDAIVFSNRPLRQRELFEVELETMVRHWSGNIEIGVTGTRPEDIQLAPNATD 735
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKA--SFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETLDLPPSATD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  736 LeASDTIILCGPMIFHNRKTIRTNILLDLDTLGPSTRVGVMRNGD-FIHFFVDGMDQGPACECHAPNIWAIIDLYGQCAQ 814
Cdd:cd12887   79 L-KSGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDgTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQ 157


                 ....
gi 24664051  815 VSLT 818
Cdd:cd12887  158 VSIV 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 225-388 1.91e-57

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 195.45  E-value: 1.91e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    225 FHTRCGSLVKLSPNFRSAERRRpldEFNNGVVMTHRPLRDNELFEIRIDKLVDKWSGSIEVGVTTHNPAVL---HFPATM 301
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTN---SFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkALPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    302 TNMRSGTIM--MSGCgiltngkgtrrqygefnldELREGDRVGMMRKANGNLHNYINGQDQGVAATRAPST--LWGVIDL 377
Cdd:pfam07177   78 TDLRPGYWVvaLSGS-------------------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDL 138

                          170
                   ....*....|.
gi 24664051    378 YGMTIKVTIVD 388
Cdd:pfam07177  139 YGQTTQVSILG 149
NEUZ smart00588
domain in neuralized proteins;
221-345 3.23e-54

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 185.21  E-value: 3.23e-54
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051     221 DRLCFHTRCGSLVKLSPNFRSAerRRPLDEFNNGVVMTHRPLRDNELFEIRIDKLVDKWSGSIEVGVTTHNPAVLHFPAT 300
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVA--RRSASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 24664051     301 MTNMRSGTIMMSGCGILTNGKGTRRQYGEFNLDELREGDRVGMMR 345
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGILGLDVLAEGEVVGVIN 123
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 468-630 8.97e-54

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 185.05  E-value: 8.97e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    468 FHHICGTHATVTQSGRTALRPNAaddFNNGVVLTRRPLRPNELFQVRLERVVTKWAGSVEMGVTTHSADEL---DFPFTM 544
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNS---FNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkALPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    545 TNVRSGTWMMTGNGvmqngvtvieqygqnlDRLQVGDRVGVVRKDDGTLHFWVNGVDQGPAANNVPER--VYGVIDLYGQ 622
Cdd:pfam07177   78 TDLRPGYWVVALSG----------------SYLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*...
gi 24664051    623 AAQASIVD 630
Cdd:pfam07177  142 TTQVSILG 149
NEUZ smart00588
domain in neuralized proteins;
464-587 3.76e-50

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 173.65  E-value: 3.76e-50
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051     464 DRLTFHHICGTHATVTQSGRTALRPnaADDFNNGVVLTRRPLRPNELFQVRLERVVTKWAGSVEMGVTTHSADELDFPFT 543
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVARRS--ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 24664051     544 MTNVRSGTWMMTGNGVMQNGVTVIEQYG-QNLDRLQVGDRVGVVR 587
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGiLGLDVLAEGEVVGVIN 123
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 9-168 1.58e-49

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 172.72  E-value: 1.58e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051      9 FHTRCGRSIRLYNNNRMAQRSmRDFSHALVFSAEPLEDDVLFEVVIEKKNTYWGGSIEIGVTAESPDDLELVAC---ATA 85
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRT-NSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRPKALpdlATD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051     86 MRNGTWVMSgidvrKDGRrlfefygtdleTLNENDRVGVMRTSGNDLVFYVNGESQGVAAKNMP--KPLWALVDLYGRCV 163
Cdd:pfam07177   80 LRPGYWVVA-----LSGS-----------YLQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPdsQPLWAVFDLYGQTT 143


                   ....*
gi 24664051    164 QVSLC 168
Cdd:pfam07177  144 QVSIL 148
NEUZ smart00588
domain in neuralized proteins;
5-126 7.24e-49

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 169.80  E-value: 7.24e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051       5 EAQSFHTRCGRSIRLYNNNRMAQRSMRDFSHALVFSAEPLEDDVLFEVVIEKKNTYWGGSIEIGVTAESPDDLELVACAT 84
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVARRSASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASLPT 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 24664051      85 AMRNGTWVMSGIDVRKDGRRLFEFYGT-DLETLNENDRVGVMR 126
Cdd:smart00588   81 NACPDLVDMSGFWAKALGEGLAEQGGIlGLDVLAEGEVVGVIN 123
NEUZ smart00588
domain in neuralized proteins;
653-777 2.84e-48

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 168.26  E-value: 2.84e-48
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051     653 VPLRFHSIHGANAGISNSGLTASRPnsLAEFNDAIVFSNRPLRQRELFEVELETMVRHWSGNIEIGVTGTRPEDIQLAPN 732
Cdd:smart00588    1 GPLRFHHRHGSNIRLSDSGRVARRS--ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLRPASL 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 24664051     733 ATDLEASDTIILCGPMIFHNRKTIRTNILLDLDTLGPSTRVGVMR 777
Cdd:smart00588   79 PTNACPDLVDMSGFWAKALGEGLAEQGGILGLDVLAEGEVVGVIN 123
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 1063-1220 3.71e-47

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 166.53  E-value: 3.71e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051 1063 EFLDVSQKNARLSDDRRSVTRIK-SYNQSIVCLNKPLCKGESISIKVDALNNKWKGTVGLGVLSASPQT--VPISLLDFK 1139
Cdd:cd12887    1 RFHENHGKNIRLSNDGRTATRVKaSFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETldLPPSATDLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051 1140 RSCWLATHDYVNINGQVMPSKYGDALEQIQVGTVITLTLTHAGMLIIMIGSTNLEDLASGLPNHVYPVFDVYGKCEKITL 1219
Cdd:cd12887   81 SGTWILSGSSVFKNGNKIRENYGPDLDRLRVGDRVGVMRTSDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQCEQVSI 160


                 .
gi 24664051 1220 I 1220
Cdd:cd12887  161 V 161
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 657-817 1.87e-43

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 155.39  E-value: 1.87e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    657 FHSIHGANAGISNSGLTASRPNSlaeFNDAIVFSNRPLRQRELFEVELETMVRHWSGNIEIGVTGTRPEDIQLA--PNAT 734
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNS---FNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLRPKalPDLA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    735 DLEASDTIILCgpmifhnrktirtnilLDLDTLGPSTRVGVMRNGD-FIHFFVDGMDQGPACECHAPN--IWAIIDLYGQ 811
Cdd:pfam07177   78 TDLRPGYWVVA----------------LSGSYLQEGDRLGFWVTSDgELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQ 141


                   ....*.
gi 24664051    812 CAQVSL 817
Cdd:pfam07177  142 TTQVSI 147
SPRY_NHR_like cd12887
SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat ...
 854-1016 1.55e-40

SPRY domain in neuralized homology repeat; This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.


Pssm-ID: 293945  Cd Length: 161  Bit Score: 147.66  E-value: 1.55e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  854 WTCVSGNVSLTKDWTEASRFtgaAAPLSHCLVFSEHPLSVGSPFEIKLTSVNSMFAGCLSIGVTDLNLSDEsvrkKLPTS 933
Cdd:cd12887    3 HENHGKNIRLSNDGRTATRV---KASFNNGVVFSSRPLRPGELFEVRIDKLVDRWSGSLEIGVTTLNPETL----DLPPS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  934 IRRIPANVWYVSGNEVCFNSSCLQRSL-ASLEWLRVDDRITLERV-ENSLNILLNSENVNIHFHNVPNDVYVVAELRGST 1011
Cdd:cd12887   76 ATDLKSGTWILSGSSVFKNGNKIRENYgPDLDRLRVGDRVGVMRTsDGTLHFYVNGEDQGVAASNVPQPVYAVVDLYGQC 155


                 ....*
gi 24664051 1012 mgIQV 1016
Cdd:cd12887  156 --EQV 158
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 1064-1220 1.89e-20

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 89.52  E-value: 1.89e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051   1064 FLDVSQKNARLSDDRRSVTRIKSYNQSIVCLNKPLCKGESISIKVDALNNKWKGTVGLGVLSASPQTV-----PISLLDF 1138
Cdd:pfam07177    1 FHPVHGKNVRLSNDGRTARRTNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDPATLrpkalPDLATDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051   1139 KRSCWLAthdyvningqVMPSKYgdaleqIQVGTVITLTLTHAGMLIIMIGSTNLEDLASGLPNH--VYPVFDVYGKCEK 1216
Cdd:pfam07177   81 RPGYWVV----------ALSGSY------LQEGDRLGFWVTSDGELHFSVNGEDQGVALSGVPDSqpLWAVFDLYGQTTQ 144


                   ....
gi 24664051   1217 ITLI 1220
Cdd:pfam07177  145 VSIL 148
Neuralized pfam07177
Neuralized; This family contains a conserved region approximately 60 residues long within ...
 860-1018 9.21e-10

Neuralized; This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.


Pssm-ID: 462112 [Multi-domain]  Cd Length: 149  Bit Score: 58.70  E-value: 9.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    860 NVSLTKDWTEASRftgaAAPLSHCLVFSEHPLSVGSPFEIKLTSVNSMFAGCLSIGVTDLN---LSDesvrKKLPTSIRR 936
Cdd:pfam07177    8 NVRLSNDGRTARR----TNSFNNGLVFSSRPLRPGELFEVRIDKLVDKWSGSLRFGVTSCDpatLRP----KALPDLATD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051    937 IPANVWYVSgnevcfnssclqrslASLEWLRVDDRITLERVEN-SLNILLNSENVNIHFHNVPN--DVYVVAELRGSTMG 1013
Cdd:pfam07177   80 LRPGYWVVA---------------LSGSYLQEGDRLGFWVTSDgELHFSVNGEDQGVALSGVPDsqPLWAVFDLYGQTTQ 144


                   ....*
gi 24664051   1014 IQVIS 1018
Cdd:pfam07177  145 VSILG 149
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 517-624 3.21e-07

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 50.89  E-value: 3.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  517 RVVTKWAGSVEMGVTTHSADELDFPFTMTNVRS----GTWMMTGNGvmqngvtviEQYGQNLDRLQVGDRVGV-VRKDDG 591
Cdd:cd11709    8 RVDSGNGGLIQVGWATKSFSLDGEGGVGDDEESwgydGSRLRKGHG---------GSSGPGGRPWKSGDVVGClLDLDEG 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 24664051  592 TLHFWVNGVDQGPAANNV---PERVYGVIDLYGQAA 624
Cdd:cd11709   79 TLSFSLNGKDLGVAFTNLflkGGGLYPAVSLGSGQG 114
NEUZ smart00588
domain in neuralized proteins;
1071-1141 3.70e-06

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 47.69  E-value: 3.70e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24664051    1071 NARLSDDRRSVTRIKS-YNQSIVCLNKPLCKGESISIKVDALNNKWKGTVGLGVLSASPQTV-PISLLDFKRS 1141
Cdd:smart00588   12 NIRLSDSGRVARRSASdFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCDPATLrPASLPTNACP 84
NEUZ smart00588
domain in neuralized proteins;
860-920 4.08e-06

domain in neuralized proteins;


Pssm-ID: 128856  Cd Length: 123  Bit Score: 47.69  E-value: 4.08e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24664051     860 NVSLTKDWTEASRFtgaAAPLSHCLVFSEHPLSVGSPFEIKLTSVNSMFAGCLSIGVTDLN 920
Cdd:smart00588   12 NIRLSDSGRVARRS---ASDFCNALVFSARPLRINELFEVKIEKVVRKWSGALRFGVTTCD 69
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 50-168 5.18e-06

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 47.43  E-value: 5.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051   50 FEVVIEKKNtywGGSIEIGVtaeSPDDLELVACATAMRNGT-WVMSGIDVRKDGRRLFEFYGtdlETLNENDRVGVMR-T 127
Cdd:cd11709    5 WEVRVDSGN---GGLIQVGW---ATKSFSLDGEGGVGDDEEsWGYDGSRLRKGHGGSSGPGG---RPWKSGDVVGCLLdL 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 24664051  128 SGNDLVFYVNGESQGVAAKN---MPKPLWALVDLYGRCvQVSLC 168
Cdd:cd11709   76 DEGTLSFSLNGKDLGVAFTNlflKGGGLYPAVSLGSGQ-GVTIN 118
SPRY_SOCS_Fbox cd12875
SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family ...
 552-623 3.30e-05

SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family consists of the SPRY domain-containing SOCS box protein family (SPSB1-4, also known as SSB-1 to -4) as well as F-box protein 45 (Fbxo45), a novel synaptic E3 and ubiquitin ligase. The SPSB protein is composed of a central SPRY protein interaction domain and a C-terminal SOCS box. SPSB1, SPSB2, and SPSB4 interact with prostate apoptosis response protein 4 (Par-4) and are negative regulators that recruit the ECS E3 ubiquitin ligase complex to polyubiquitinate inducible nitric-oxide synthase (iNOS), resulting in its proteasomal degradation. Fbxo45 is related to this family; it is located N-terminal to the SPRY domain, and known to induce the degradation of a synaptic vesicle-priming factor, Munc13-1, via the SPRY domain, thus playing an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse. Suppressor of cytokine signaling (SOCS) proteins negatively regulate signaling from JAK-associated cytokine receptor complexes, and play key roles in the regulation of immune homeostasis.


Pssm-ID: 293935  Cd Length: 169  Bit Score: 46.29  E-value: 3.30e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24664051  552 WMMTGNGVMQNGVTVIEQYGQNLDRLQVGDRVGVV-RKDDGTLHFWVNGVDQGPAANNVPER-VY-GVIDLYGQA 623
Cdd:cd12875   88 WDLGDNKLYHNGKKVIGSYPAKSENYQVPDRILVIlDMEDGTLAFEANGEYLGVAFRGLPGKlLYpAVSAVYGNC 162
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 268-365 3.66e-04

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 42.03  E-value: 3.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051  268 FEIRIDKlvdKWSGSIEVGVTTHNPAVLHFPATMTNMRSgtimmsgCGILTNGKGTR-RQYGEFNLDELREGDRVGMMRK 346
Cdd:cd11709    5 WEVRVDS---GNGGLIQVGWATKSFSLDGEGGVGDDEES-------WGYDGSRLRKGhGGSSGPGGRPWKSGDVVGCLLD 74

                         90       100
                 ....*....|....*....|
gi 24664051  347 AN-GNLHNYINGQDQGVAAT 365
Cdd:cd11709   75 LDeGTLSFSLNGKDLGVAFT 94
SPRY pfam00622
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ...
 50-170 5.69e-04

SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.


Pssm-ID: 459877  Cd Length: 121  Bit Score: 41.56  E-value: 5.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664051     50 FEVVIEKKNtywGGSIEIGV-TAESPDDLELVACataMRNGTWVMSGIDVRKDGRRLFEFYGTDLETlnENDRVGVM-RT 127
Cdd:pfam00622    4 FEVEIFGQD---GGGWRVGWaTKSVPRKGERFLG---DESGSWGYDGWTGKKYWASTSPLTGLPLFE--PGDVIGCFlDY 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 24664051    128 SGNDLVFYVNGESQGVAAKNMP--KPLWALVDLY-GRCVQVSLCPR 170
Cdd:pfam00622   76 EAGTISFTKNGKSLGYAFRDVPfaGPLFPAVSLGaGEGLKFNFGLR 121
Sortase_F cd05829
Sortase domain found in the class F family of sortases; Class F sortases are mainly present in ...
 573-615 1.56e-03

Sortase domain found in the class F family of sortases; Class F sortases are mainly present in Actinobacteria, Chlorobacteria and Firmicutes. Their functions are largely unknown.


Pssm-ID: 320678  Cd Length: 144  Bit Score: 40.68  E-value: 1.56e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 24664051  573 NLDRLQVGDRVGVVRKDDGTLHFWVNGVDQGPAANNVPERVYG 615
Cdd:cd05829   70 RLGDLRPGDEVTVTRADGTTATFRVTSVETYPKDDLPTDEVFG 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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