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Conserved domains on  [gi|19173074|ref|NP_597625|]
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uncharacterized protein ECU03_1160 [Encephalitozoon cuniculi GB-M1]

Protein Classification

SAC family polyphosphoinositide phosphatase( domain architecture ID 11474933)

SAC family polyphosphoinositide phosphatase catalyzes the hydrolysis of phosphatidylinositol (PtdIns) phosphates, such as PtdIns(3)P, PtdIns(4)P, and/or PtdIns(3,5)P2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
8-516 0e+00

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


:

Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 588.59  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074   8 KVTVSPEEIVFESINGNGTFAMKGQHIDSRKSAYHSYGVYGMITISKSSYLILVVDAVIRGMMYEHAVYEIRDVEIIQLT 87
Cdd:COG5329  25 RLGVKNSERILCATELVGVRFEPDEGFSSLSSAHKIYGVIGLIKLKGDIYLIVITGASLVGVIPGHSIYKILDVDFISLN 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074  88 REKAKNFTNEMKN------VKKFLEKTGIYFSTYPLYKTMSIKKD-----------EDKDFLFNSLPLEKFLGHAGDKGS 150
Cdd:COG5329 105 NNKWDDELEEDEAnydklsELKKLLSNGTFYFSYDFDITNSLQKNlsegleasvdrADLIFMWNSFLLEEFINHRSKLSS 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074 151 LFS------VWCIQGFFGSVDIG----TVCLRLISRRSWRRAGARYFSRGSDASGYVSNYVETEQIIYDGEKTVSHLQVR 220
Cdd:COG5329 185 LEKqfdnflTTVIRGFAETVDIKvggnTISLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQYIFSFTQVR 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074 221 GSIPLIWEHVlGREYNPKIVVSD-----RKILHIADKVLRDKYGDVFYLNLIRNSGYEGMLHCAYEKELLGNNKEGVH-- 293
Cdd:COG5329 265 GSIPLFWEQS-NLLYGPKIKVTRsseaaQSAFDKHFDKLREKYGDVYVVNLLKTKGYEAPLLELYEKHLDLSKKPKIHyt 343

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074 294 -FNFFKEGGILEGDTRKKFLGLVEQALLSFGYHG-------PGSLQSGVIRTNCIDCLDRTNISQFIMGEIILEKQLSHF 365
Cdd:COG5329 344 eFDFHKETSQDGFDDVKKLLYLIEQDLLEFGYFAydinegkSISEQDGVFRTNCLDCLDRTNVIQSLISRVLLEQFRSEG 423

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074 366 DIEDKKH-FCEQAKCLWYDNGNSLSMQYSGSFALKSHFLSRKRQGVVDRLRDGIIGFQRYFINRLCHGSLQTTYEILTTD 444
Cdd:COG5329 424 VISDGYSpFLQIHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLGK 503

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19173074 445 LDGKTIISYRDrvgtIRKTFLLLLITVCTASWVSTGIFIISLLCSTLAITLVTiAVVLIFLDSLIQKPRPRA 516
Cdd:COG5329 504 FRPQEAFSYRP----LRITFLLLMITACTISWFSTIIFISSLLCSNPSLLLVL-AVILIVLSKLYQFPHGRQ 570
 
Name Accession Description Interval E-value
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
8-516 0e+00

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 588.59  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074   8 KVTVSPEEIVFESINGNGTFAMKGQHIDSRKSAYHSYGVYGMITISKSSYLILVVDAVIRGMMYEHAVYEIRDVEIIQLT 87
Cdd:COG5329  25 RLGVKNSERILCATELVGVRFEPDEGFSSLSSAHKIYGVIGLIKLKGDIYLIVITGASLVGVIPGHSIYKILDVDFISLN 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074  88 REKAKNFTNEMKN------VKKFLEKTGIYFSTYPLYKTMSIKKD-----------EDKDFLFNSLPLEKFLGHAGDKGS 150
Cdd:COG5329 105 NNKWDDELEEDEAnydklsELKKLLSNGTFYFSYDFDITNSLQKNlsegleasvdrADLIFMWNSFLLEEFINHRSKLSS 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074 151 LFS------VWCIQGFFGSVDIG----TVCLRLISRRSWRRAGARYFSRGSDASGYVSNYVETEQIIYDGEKTVSHLQVR 220
Cdd:COG5329 185 LEKqfdnflTTVIRGFAETVDIKvggnTISLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQYIFSFTQVR 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074 221 GSIPLIWEHVlGREYNPKIVVSD-----RKILHIADKVLRDKYGDVFYLNLIRNSGYEGMLHCAYEKELLGNNKEGVH-- 293
Cdd:COG5329 265 GSIPLFWEQS-NLLYGPKIKVTRsseaaQSAFDKHFDKLREKYGDVYVVNLLKTKGYEAPLLELYEKHLDLSKKPKIHyt 343

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074 294 -FNFFKEGGILEGDTRKKFLGLVEQALLSFGYHG-------PGSLQSGVIRTNCIDCLDRTNISQFIMGEIILEKQLSHF 365
Cdd:COG5329 344 eFDFHKETSQDGFDDVKKLLYLIEQDLLEFGYFAydinegkSISEQDGVFRTNCLDCLDRTNVIQSLISRVLLEQFRSEG 423

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074 366 DIEDKKH-FCEQAKCLWYDNGNSLSMQYSGSFALKSHFLSRKRQGVVDRLRDGIIGFQRYFINRLCHGSLQTTYEILTTD 444
Cdd:COG5329 424 VISDGYSpFLQIHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLGK 503

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19173074 445 LDGKTIISYRDrvgtIRKTFLLLLITVCTASWVSTGIFIISLLCSTLAITLVTiAVVLIFLDSLIQKPRPRA 516
Cdd:COG5329 504 FRPQEAFSYRP----LRITFLLLMITACTISWFSTIIFISSLLCSNPSLLLVL-AVILIVLSKLYQFPHGRQ 570
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
 44-299 7.22e-52

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 178.15  E-value: 7.22e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074    44 YGVYGMITISKSSYLILVVDAVIRGMMYEHAVYEIRDVEIIQLTREKAKNFTNE---------MKNVKKFLEKTGIYFS- 113
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNSSLSDTQLAKkehpdeerlLKLLKLFLSSGSFYFSy 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074   114 ----TYPLYKTMSIKKDE-----DKDFLFNSLPLEKFLGHAGDkgslFSVWC---IQGFFG----SVDIGTVCLRLISRR 177
Cdd:pfam02383  81 dydlTNSLQRNLTRSRSPsfdslDDRFFWNRHLLKPLIDFQLD----LDRWIlplIQGFVEqgklSVFGRSVTLTLISRR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074   178 SWRRAGARYFSRGSDASGYVSNYVETEQIIYD-----GEKTVSHLQVRGSIPLIWEHVLGREYNPKIVVSDRKI------ 246
Cdd:pfam02383 157 SRKRAGTRYLRRGIDDDGNVANFVETEQIVSLntsnsEGKIFSFVQIRGSIPLFWSQDPNLKYKPKIQITRPEAtqpafk 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 19173074   247 LHIADkvLRDKYGDVFYLNLIRNSGYEGMLHCAYEKELLGNNKEG------VHFNFFKE 299
Cdd:pfam02383 237 KHFDD--LIERYGPVHIVNLVEKKGRESKLSEAYEEAVKYLNQFLpdklryTAFDFHHE 293
 
Name Accession Description Interval E-value
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
8-516 0e+00

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 588.59  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074   8 KVTVSPEEIVFESINGNGTFAMKGQHIDSRKSAYHSYGVYGMITISKSSYLILVVDAVIRGMMYEHAVYEIRDVEIIQLT 87
Cdd:COG5329  25 RLGVKNSERILCATELVGVRFEPDEGFSSLSSAHKIYGVIGLIKLKGDIYLIVITGASLVGVIPGHSIYKILDVDFISLN 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074  88 REKAKNFTNEMKN------VKKFLEKTGIYFSTYPLYKTMSIKKD-----------EDKDFLFNSLPLEKFLGHAGDKGS 150
Cdd:COG5329 105 NNKWDDELEEDEAnydklsELKKLLSNGTFYFSYDFDITNSLQKNlsegleasvdrADLIFMWNSFLLEEFINHRSKLSS 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074 151 LFS------VWCIQGFFGSVDIG----TVCLRLISRRSWRRAGARYFSRGSDASGYVSNYVETEQIIYDGEKTVSHLQVR 220
Cdd:COG5329 185 LEKqfdnflTTVIRGFAETVDIKvggnTISLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQYIFSFTQVR 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074 221 GSIPLIWEHVlGREYNPKIVVSD-----RKILHIADKVLRDKYGDVFYLNLIRNSGYEGMLHCAYEKELLGNNKEGVH-- 293
Cdd:COG5329 265 GSIPLFWEQS-NLLYGPKIKVTRsseaaQSAFDKHFDKLREKYGDVYVVNLLKTKGYEAPLLELYEKHLDLSKKPKIHyt 343

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074 294 -FNFFKEGGILEGDTRKKFLGLVEQALLSFGYHG-------PGSLQSGVIRTNCIDCLDRTNISQFIMGEIILEKQLSHF 365
Cdd:COG5329 344 eFDFHKETSQDGFDDVKKLLYLIEQDLLEFGYFAydinegkSISEQDGVFRTNCLDCLDRTNVIQSLISRVLLEQFRSEG 423

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074 366 DIEDKKH-FCEQAKCLWYDNGNSLSMQYSGSFALKSHFLSRKRQGVVDRLRDGIIGFQRYFINRLCHGSLQTTYEILTTD 444
Cdd:COG5329 424 VISDGYSpFLQIHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLGK 503

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19173074 445 LDGKTIISYRDrvgtIRKTFLLLLITVCTASWVSTGIFIISLLCSTLAITLVTiAVVLIFLDSLIQKPRPRA 516
Cdd:COG5329 504 FRPQEAFSYRP----LRITFLLLMITACTISWFSTIIFISSLLCSNPSLLLVL-AVILIVLSKLYQFPHGRQ 570
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
 44-299 7.22e-52

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 178.15  E-value: 7.22e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074    44 YGVYGMITISKSSYLILVVDAVIRGMMYEHAVYEIRDVEIIQLTREKAKNFTNE---------MKNVKKFLEKTGIYFS- 113
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNSSLSDTQLAKkehpdeerlLKLLKLFLSSGSFYFSy 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074   114 ----TYPLYKTMSIKKDE-----DKDFLFNSLPLEKFLGHAGDkgslFSVWC---IQGFFG----SVDIGTVCLRLISRR 177
Cdd:pfam02383  81 dydlTNSLQRNLTRSRSPsfdslDDRFFWNRHLLKPLIDFQLD----LDRWIlplIQGFVEqgklSVFGRSVTLTLISRR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173074   178 SWRRAGARYFSRGSDASGYVSNYVETEQIIYD-----GEKTVSHLQVRGSIPLIWEHVLGREYNPKIVVSDRKI------ 246
Cdd:pfam02383 157 SRKRAGTRYLRRGIDDDGNVANFVETEQIVSLntsnsEGKIFSFVQIRGSIPLFWSQDPNLKYKPKIQITRPEAtqpafk 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 19173074   247 LHIADkvLRDKYGDVFYLNLIRNSGYEGMLHCAYEKELLGNNKEG------VHFNFFKE 299
Cdd:pfam02383 237 KHFDD--LIERYGPVHIVNLVEKKGRESKLSEAYEEAVKYLNQFLpdklryTAFDFHHE 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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