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Conserved domains on  [gi|19173488|ref|NP_597291|]
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uncharacterized protein ECU08_1630 [Encephalitozoon cuniculi GB-M1]

Protein Classification

CPSF4/YTH1 family protein( domain architecture ID 11473782)

CPSF4/YTH1 family protein similar to Homo sapiens cleavage and polyadenylation specificity factor subunit 4, as well as Saccharomyces cerevisiae mRNA 3'-end-processing protein YTH1 and zinc finger protein LEE1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 1-286 3.38e-97

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


:

Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 288.31  E-value: 3.38e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173488   1 MRNVCRFFIEGKCKFGSKCKYDHVRYTSLVDPPQWIYSSYRGLDLMEISPEEVRFALMCGDMKEVLDNFWIGNYMALCGE 80
Cdd:COG5084   1 EKNVCSFAIDGKCNLGSGCTYNHSNYTSLNDGLQSVSSKYMGAKQISPSLSSPTFKNKANLMQNTNDNFVPGNTVACISR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173488  81 MDLLESDARIaSVSNRHVDPRENPDVFMAPFDVDRVSGTIRQMRAQGARPLEKrQGDTRRGDGGWGSTSLGSPRPHPTGD 160
Cdd:COG5084  81 NFNSIRGSRL-STPNNHVNPVLSSSVVCKFFLRGLCKSGFSCEFLHEYDLRSS-QGPPCRSFSLKGSCSSGPSCGYSHID 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173488 161 ggyKDKRYGWSRQESGAgSAWFQGNKAGDRAGHGGYRSGYGGEPRGFPREPSYPKGNDSEYrqKGSWGYGKGTSKKYSKP 240
Cdd:COG5084 159 ---PDSFAGNCDQYSGA-TYGFCPLGASCKFSHTLKRVSYGSSPCGNYTPPFSPPGTPSES--VSSWGYGKGTSCSLSHP 232

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 19173488 241 EDEFDIQDTPSSFPGAYSGGTPRAGGAWTHNSEALGDRQNASRGSG 286
Cdd:COG5084 233 SLNIDIQQPQTAPSRKDSGGTNPIGASSEIGSEADGNMQNSISGSG 278
 
Name Accession Description Interval E-value
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 1-286 3.38e-97

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 288.31  E-value: 3.38e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173488   1 MRNVCRFFIEGKCKFGSKCKYDHVRYTSLVDPPQWIYSSYRGLDLMEISPEEVRFALMCGDMKEVLDNFWIGNYMALCGE 80
Cdd:COG5084   1 EKNVCSFAIDGKCNLGSGCTYNHSNYTSLNDGLQSVSSKYMGAKQISPSLSSPTFKNKANLMQNTNDNFVPGNTVACISR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173488  81 MDLLESDARIaSVSNRHVDPRENPDVFMAPFDVDRVSGTIRQMRAQGARPLEKrQGDTRRGDGGWGSTSLGSPRPHPTGD 160
Cdd:COG5084  81 NFNSIRGSRL-STPNNHVNPVLSSSVVCKFFLRGLCKSGFSCEFLHEYDLRSS-QGPPCRSFSLKGSCSSGPSCGYSHID 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173488 161 ggyKDKRYGWSRQESGAgSAWFQGNKAGDRAGHGGYRSGYGGEPRGFPREPSYPKGNDSEYrqKGSWGYGKGTSKKYSKP 240
Cdd:COG5084 159 ---PDSFAGNCDQYSGA-TYGFCPLGASCKFSHTLKRVSYGSSPCGNYTPPFSPPGTPSES--VSSWGYGKGTSCSLSHP 232

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 19173488 241 EDEFDIQDTPSSFPGAYSGGTPRAGGAWTHNSEALGDRQNASRGSG 286
Cdd:COG5084 233 SLNIDIQQPQTAPSRKDSGGTNPIGASSEIGSEADGNMQNSISGSG 278
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 5-23 1.01e-05

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 41.63  E-value: 1.01e-05
                          10
                  ....*....|....*....
gi 19173488     5 CRFFIEGKCKFGSKCKYDH 23
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
ZnF_C3H1 smart00356
zinc finger;
4-25 3.28e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.22  E-value: 3.28e-04
                           10        20
                   ....*....|....*....|..
gi 19173488      4 VCRFFIEGKCKFGSKCKYDHVR 25
Cdd:smart00356   6 LCKFFKRGYCPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 1-286 3.38e-97

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 288.31  E-value: 3.38e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173488   1 MRNVCRFFIEGKCKFGSKCKYDHVRYTSLVDPPQWIYSSYRGLDLMEISPEEVRFALMCGDMKEVLDNFWIGNYMALCGE 80
Cdd:COG5084   1 EKNVCSFAIDGKCNLGSGCTYNHSNYTSLNDGLQSVSSKYMGAKQISPSLSSPTFKNKANLMQNTNDNFVPGNTVACISR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173488  81 MDLLESDARIaSVSNRHVDPRENPDVFMAPFDVDRVSGTIRQMRAQGARPLEKrQGDTRRGDGGWGSTSLGSPRPHPTGD 160
Cdd:COG5084  81 NFNSIRGSRL-STPNNHVNPVLSSSVVCKFFLRGLCKSGFSCEFLHEYDLRSS-QGPPCRSFSLKGSCSSGPSCGYSHID 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19173488 161 ggyKDKRYGWSRQESGAgSAWFQGNKAGDRAGHGGYRSGYGGEPRGFPREPSYPKGNDSEYrqKGSWGYGKGTSKKYSKP 240
Cdd:COG5084 159 ---PDSFAGNCDQYSGA-TYGFCPLGASCKFSHTLKRVSYGSSPCGNYTPPFSPPGTPSES--VSSWGYGKGTSCSLSHP 232

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 19173488 241 EDEFDIQDTPSSFPGAYSGGTPRAGGAWTHNSEALGDRQNASRGSG 286
Cdd:COG5084 233 SLNIDIQQPQTAPSRKDSGGTNPIGASSEIGSEADGNMQNSISGSG 278
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 5-23 1.01e-05

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 41.63  E-value: 1.01e-05
                          10
                  ....*....|....*....
gi 19173488     5 CRFFIEGKCKFGSKCKYDH 23
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
ZnF_C3H1 smart00356
zinc finger;
4-25 3.28e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 37.22  E-value: 3.28e-04
                           10        20
                   ....*....|....*....|..
gi 19173488      4 VCRFFIEGKCKFGSKCKYDHVR 25
Cdd:smart00356   6 LCKFFKRGYCPRGDRCKFAHPL 27
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 3-23 6.77e-04

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 36.41  E-value: 6.77e-04
                          10        20
                  ....*....|....*....|.
gi 19173488     3 NVCRFFIEGKCKFGSKCKYDH 23
Cdd:pfam18044   1 RLCRYFQKGGCRYGDNCRFSH 21
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
2-25 1.47e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 35.63  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*
gi 19173488     2 RNVCRFFIE-GKCKFGSKCKYDHVR 25
Cdd:pfam00642   3 TELCRFFLRtGYCKYGDRCKFAHGQ 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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